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1. Strong coupling effects on near-barrier 15C + 208Pb elastic scattering

Author

V.G. Távora, J.D. Ovejas, I. Martel, N. Keeley, L. Acosta, M.J.G. Borge, O. Tengblad, A.A. Arokiaraj, M. Babo, J. Cederkall, N. Ceylan, A. Di Pietro, J.P. Fernández-García, P. Figuera, L.M. Fraile, H.O.U. Fynbo, D. Galaviz, C. García-Ramos, R. Honório, J.H. Jensen, B. Jonson, K.W. Kemper, A. Knyazev, R. Kotak, T. Kurtukian-Nieto, M. Madurga, G. Marquínez-Durán, M. Munch, A.K. Orduz, J. Park, L. Peralta, A. Perea, T. Pérez-Alvarez, R. Raabe, M. Renaud, K. Riisager, K. Rusek, A.M. Sánchez-Benítez, J. Sánchez-Segovia, P. Teubig, S. Viñals, M. Wolińska-Cichocka, R. Wolski, and J. Yang

Subjects
Direct nuclear reactions, Radioactive beams, Elastic scattering, Optical model, Coupled channels, Physics, QC1-999
Abstract

The presence of a neutron halo in 15C has been demonstrated in several reaction experiments at intermediate energies. In the present study, the dynamical effects of this structure are observed for the first time at Coulomb barrier energies in the 15C + 208Pb quasi-elastic scattering at Elab=65 MeV, measured at the HIE-ISOLDE facility, CERN using the high-granularity detector array GLORIA. A combined continuum discretised coupled channels and coupled reaction channels calculation describes the data well and significant coupling effects due both to breakup and single-neutron stripping are identified.

Published
2024
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2. Very-high-energy γ-Ray Emission from Young Massive Star Clusters in the Large Magellanic Cloud

Author

F. Aharonian, F. Ait Benkhali, J. Aschersleben, H. Ashkar, M. Backes, V. Barbosa Martins, R. Batzofin, Y. Becherini, D. Berge, K. Bernlöhr, M. Böttcher, J. Bolmont, M. de Bony de Lavergne, J. Borowska, R. Brose, A. Brown, F. Brun, B. Bruno, C. Burger-Scheidlin, S. Casanova, J. Celic, M. Cerruti, T. Chand, S. Chandra, A. Chen, J. Chibueze, O. Chibueze, G. Cotter, P. Cristofari, J. Devin, A. Djannati-Ataï, J. Djuvsland, A. Dmytriiev, K. Egberts, S. Einecke, K. Feijen, M. Filipovic, G. Fontaine, S. Funk, S. Gabici, Y. A. Gallant, J. F. Glicenstein, J. Glombitza, G. Grolleron, L. Haerer, B. Heß, J. A. Hinton, W. Hofmann, T. L. Holch, D. Horns, Zhiqiu Huang, M. Jamrozy, F. Jankowsky, I. Jung-Richardt, E. Kasai, K. Katarzyński, R. Khatoon, B. Khélifi, W. Kluźniak, Nu. Komin, K. Kosack, D. Kostunin, A. Kundu, R. G. Lang, S. Le Stum, A. Lemière, M. Lemoine-Goumard, J.-P. Lenain, F. Leuschner, J. Mackey, V. Marandon, G. Martí-Devesa, R. Marx, A. Mehta, A. Mitchell, R. Moderski, M. O. Moghadam, L. Mohrmann, A. Montanari, E. Moulin, M. de Naurois, J. Niemiec, S. Ohm, L. Olivera-Nieto, E. de Ona Wilhelmi, M. Ostrowski, S. Panny, U. Pensec, G. Peron, G. Pühlhofer, A. Quirrenbach, S. Ravikularaman, M. Regeard, A. Reimer, O. Reimer, H. Ren, M. Renaud, B. Reville, F. Rieger, G. Rowell, B. Rudak, E. Ruiz-Velasco, K. Sabri, V. Sahakian, H. Salzmann, A. Santangelo, M. Sasaki, J. Schäfer, F. Schüssler, H. M. Schutte, H. Sol, S. Spencer, Ł. Stawarz, S. Steinmassl, C. Steppa, K. Streil, I. Sushch, A. M. Taylor, R. Terrier, M. Tsirou, N. Tsuji, C. van Eldik, M. Vecchi, C. Venter, J. Vink, S. J. Wagner, R. White, A. Wierzcholska, M. Zacharias, A. A. Zdziarski, A. Zech, N. Żywucka, and H.E.S.S. Collaboration

Subjects
Young star clusters, Massive stars, Large Magellanic Cloud, Gamma-ray astronomy, Astrophysics, QB460-466
Abstract

The Tarantula Nebula in the Large Magellanic Cloud is known for its high star formation activity. At its center lies the young massive star cluster R136, providing a significant amount of the energy that makes the nebula shine so brightly at many wavelengths. Recently, young massive star clusters have been suggested to also efficiently produce very high-energy cosmic rays, potentially beyond PeV energies. Here, we report the detection of very-high-energy γ -ray emission from the direction of R136 with the High Energy Stereoscopic System, achieved through a multicomponent, likelihood-based modeling of the data. This supports the hypothesis that R136 is indeed a very powerful cosmic-ray accelerator. Moreover, from the same analysis, we provide an updated measurement of the γ -ray emission from 30 Dor C, the only superbubble detected at TeV energies presently. The γ -ray luminosity above 0.5 TeV of both sources is (2–3) × 10 ^35 erg s ^−1 . This exceeds by more than a factor of 2 the luminosity of HESS J1646−458, which is associated with the most massive young star cluster in the Milky Way, Westerlund 1. Furthermore, the γ -ray emission from each source is extended with a significance of >3 σ and a Gaussian width of about 30 pc. For 30 Dor C, a connection between the γ -ray emission and the nonthermal X-ray emission appears likely. Different interpretations of the γ -ray signal from R136 are discussed.

Published
2024
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3. H.E.S.S. Follow-up Observations of GRB 221009A

Author

F. Aharonian, F. Ait Benkhali, J. Aschersleben, H. Ashkar, M. Backes, A. Baktash, V. Barbosa Martins, R. Batzofin, Y. Becherini, D. Berge, K. Bernlöhr, B. Bi, M. Böttcher, C. Boisson, J. Bolmont, M. de Bony de Lavergne, J. Borowska, M. Bouyahiaoui, F. Bradascio, M. Breuhaus, R. Brose, F. Brun, B. Bruno, T. Bulik, C. Burger-Scheidlin, S. Caroff, S. Casanova, J. Celic, M. Cerruti, T. Chand, S. Chandra, A. Chen, J. Chibueze, O. Chibueze, G. Cotter, S. Dai, J. Damascene Mbarubucyeye, J. Devin, A. Djannati-Ataï, A. Dmytriiev, V. Doroshenko, K. Egberts, S. Einecke, J.-P. Ernenwein, S. Fegan, G. Fichet de Clairfontaine, M. Filipovic, G. Fontaine, M. Füßling, S. Funk, S. Gabici, S. Ghafourizadeh, G. Giavitto, D. Glawion, J. F. Glicenstein, P. Goswami, G. Grolleron, M.-H. Grondin, J. A. Hinton, T. L. Holch, M. Holler, D. Horns, Zhiqiu Huang, M. Jamrozy, F. Jankowsky, V. Joshi, I. Jung-Richardt, E. Kasai, K. Katarzyński, R. Khatoon, B. Khélifi, W. Kluźniak, Nu. Komin, R. Konno, K. Kosack, D. Kostunin, R. G. Lang, S. Le Stum, F. Leitl, A. Lemière, M. Lemoine-Goumard, J.-P. Lenain, F. Leuschner, T. Lohse, I. Lypova, J. Mackey, D. Malyshev, V. Marandon, P. Marchegiani, A. Marcowith, G. Martí-Devesa, R. Marx, M. Meyer, A. Mitchell, L. Mohrmann, A. Montanari, E. Moulin, T. Murach, K. Nakashima, M. de Naurois, J. Niemiec, A. Priyana Noel, P. O’Brien, S. Ohm, L. Olivera-Nieto, E. de Ona Wilhelmi, M. Ostrowski, S. Panny, M. Panter, R. D. Parsons, G. Peron, D. A. Prokhorov, H. Prokoph, G. Pühlhofer, M. Punch, A. Quirrenbach, P. Reichherzer, A. Reimer, O. Reimer, H. Ren, M. Renaud, B. Reville, F. Rieger, G. Rowell, B. Rudak, E. Ruiz-Velasco, V. Sahakian, H. Salzmann, A. Santangelo, M. Sasaki, J. Schäfer, F. Schüssler, H. M. Schutte, U. Schwanke, J. N. S. Shapopi, A. Specovius, S. Spencer, Ł. Stawarz, R. Steenkamp, S. Steinmassl, C. Steppa, I. Sushch, H. Suzuki, T. Takahashi, T. Tanaka, R. Terrier, N. Tsuji, Y. Uchiyama, M. Vecchi, C. Venter, J. Vink, S. J. Wagner, R. White, A. Wierzcholska, Yu Wun Wong, M. Zacharias, D. Zargaryan, A. A. Zdziarski, A. Zech, S. J. Zhu, N. Żywucka, and H.E.S.S. Collaboration

Subjects
Gamma-rays, Gamma-ray bursts, Non-thermal radiation sources, High-energy cosmic radiation, Astrophysics, QB460-466
Abstract

GRB 221009A is the brightest gamma-ray burst (GRB) ever detected. To probe the very-high-energy (VHE; >100 GeV) emission, the High Energy Stereoscopic System (H.E.S.S.) began observations 53 hr after the triggering event, when the brightness of the moonlight no longer precluded observations. We derive differential and integral upper limits using H.E.S.S. data from the third, fourth, and ninth nights after the initial GRB detection, after applying atmospheric corrections. The combined observations yield an integral energy flux upper limit of ${{\rm{\Phi }}}_{\mathrm{UL}}^{95 \% }=9.7\times {10}^{-12}\,\mathrm{erg}\,{\mathrm{cm}}^{-2}\,{{\rm{s}}}^{-1}$ above E _thr = 650 GeV. The constraints derived from the H.E.S.S. observations complement the available multiwavelength data. The radio to X-ray data are consistent with synchrotron emission from a single electron population, with the peak in the spectral energy distribution occurring above the X-ray band. Compared to the VHE-bright GRB 190829A, the upper limits for GRB 221009A imply a smaller gamma-ray to X-ray flux ratio in the afterglow. Even in the absence of a detection, the H.E.S.S. upper limits thus contribute to the multiwavelength picture of GRB 221009A, effectively ruling out an IC-dominated scenario.

Published
2023
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4. Multiwavelength Observations of the Blazar PKS 0735+178 in Spatial and Temporal Coincidence with an Astrophysical Neutrino Candidate IceCube-211208A

Author

A. Acharyya, C. B. Adams, A. Archer, P. Bangale, J. T. Bartkoske, P. Batista, W. Benbow, A. Brill, J. H. Buckley, J. L. Christiansen, A. J. Chromey, M. Errando, A. Falcone, Q. Feng, G. M. Foote, L. Fortson, A. Furniss, G. Gallagher, W. Hanlon, D. Hanna, O. Hervet, C. E. Hinrichs, J. Hoang, J. Holder, T. B. Humensky, W. Jin, P. Kaaret, M. Kertzman, M. Kherlakian, D. Kieda, T. K. Kleiner, N. Korzoun, S. Kumar, M. J. Lang, M. Lundy, G. Maier, C. E McGrath, M. J. Millard, J. Millis, C. L. Mooney, P. Moriarty, R. Mukherjee, S. O’Brien, R. A. Ong, M. Pohl, E. Pueschel, J. Quinn, K. Ragan, P. T. Reynolds, D. Ribeiro, E. Roache, I. Sadeh, A. C. Sadun, L. Saha, M. Santander, G. H. Sembroski, R. Shang, M. Splettstoesser, A. Kaushik Talluri, J. V. Tucci, V. V. Vassiliev, A. Weinstein, D. A. Williams, S. L. Wong, J. Woo, The VERITAS Collaboration, F. Aharonian, J. Aschersleben, M. Backes, V. Barbosa Martins, R. Batzofin, Y. Becherini, D. Berge, K. Bernlöhr, B. Bi, M. Böttcher, C. Boisson, J. Bolmont, M. de Bony de Lavergne, J. Borowska, M. Bouyahiaoui, F. Bradascio, M. Breuhaus, R. Brose, F. Brun, B. Bruno, T. Bulik, C. Burger-Scheidlin, S. Caroff, S. Casanova, R. Cecil, J. Celic, M. Cerruti, T. Chand, S. Chandra, A. Chen, J. Chibueze, O. Chibueze, G. Cotter, S. Dai, J. Damascene Mbarubucyeye, A. Djannati-Ataï, A. Dmytriiev, V. Doroshenko, S. Einecke, J.-P. Ernenwein, G. Fichet de Clairfontaine, M. Filipovic, G. Fontaine, M. Füßling, S. Funk, S. Gabici, S. Ghafourizadeh, G. Giavitto, D. Glawion, J. F. Glicenstein, P. Goswami, G. Grolleron, L. Haerer, J. A. Hinton, T. L. Holch, M. Holler, D. Horns, M. Jamrozy, F. Jankowsky, V. Joshi, I. Jung-Richardt, E. Kasai, K. Katarzyński, R. Khatoon, B. Khélifi, S. Klepser, W. Kluźniak, K. Kosack, D. Kostunin, R. G. Lang, S. Le Stum, A. Lemière, J.-P. Lenain, F. Leuschner, T. Lohse, A. Luashvili, I. Lypova, J. Mackey, D. Malyshev, V. Marandon, P. Marchegiani, A. Marcowith, G. Martí-Devesa, R. Marx, A. Mitchell, R. Moderski, L. Mohrmann, A. Montanari, E. Moulin, T. Murach, K. Nakashima, J. Niemiec, A. Priyana Noel, P. O’Brien, L. Olivera-Nieto, E. de Ona Wilhelmi, M. Ostrowski, S. Panny, M. Panter, G. Peron, D. A. Prokhorov, G. Pühlhofer, M. Punch, A. Quirrenbach, P. Reichherzer, A. Reimer, O. Reimer, H. Ren, M. Renaud, F. Rieger, B. Rudak, E. Ruiz-Velasco, V. Sahakian, A. Santangelo, M. Sasaki, J. Schäfer, F. Schüssler, H. M. Schutte, U. Schwanke, J. N. S. Shapopi, A. Specovius, S. Spencer, Ł. Stawarz, R. Steenkamp, S. Steinmassl, I. Sushch, H. Suzuki, T. Takahashi, T. Tanaka, R. Terrier, C. van Eldik, M. Vecchi, J. Veh, C. Venter, J. Vink, R. White, A. Wierzcholska, Yu Wun Wong, M. Zacharias, D. Zargaryan, A. A. Zdziarski, A. Zech, S. Zouari, N. Żywucka, The H.E.S.S. Collaboration, and K. Mori

Subjects
Active galactic nuclei, Blazars, Neutrino astronomy, Gamma-ray astronomy, Astrophysics, QB460-466
Abstract

We report on multiwavelength target-of-opportunity observations of the blazar PKS 0735+178, located 2.°2 away from the best-fit position of the IceCube neutrino event IceCube-211208A detected on 2021 December 8. The source was in a high-flux state in the optical, ultraviolet, X-ray, and GeV γ -ray bands around the time of the neutrino event, exhibiting daily variability in the soft X-ray flux. The X-ray data from Swift-XRT and NuSTAR characterize the transition between the low-energy and high-energy components of the broadband spectral energy distribution (SED), and the γ -ray data from Fermi-LAT, VERITAS, and H.E.S.S. require a spectral cutoff near 100 GeV. Both the X-ray and γ -ray measurements provide strong constraints on the leptonic and hadronic models. We analytically explore a synchrotron self-Compton model, an external Compton model, and a lepto-hadronic model. Models that are entirely based on internal photon fields face serious difficulties in matching the observed SED. The existence of an external photon field in the source would instead explain the observed γ -ray spectral cutoff in both the leptonic and lepto-hadronic models and allow a proton jet power that marginally agrees with the Eddington limit in the lepto-hadronic model. We show a numerical lepto-hadronic model with external target photons that reproduces the observed SED and is reasonably consistent with the neutrino event despite requiring a high jet power.

Published
2023
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7. Impact of residual subtraction on myocardial blood flow and reserve estimates from rapid dynamic PET protocols

Author

Jennifer M. Renaud, Alexis Poitrasson-Rivière, Richard L Weinberg, Liliana Arida-Moody, Jonathan B. Moody, Venkatesh L. Murthy, Christopher Buckley, Tomoe Hagio, and Edward P. Ficaro

Subjects
medicine.medical_specialty, education.field_of_study, business.industry, Population, Subtraction, Blood flow, Residual, Time Activity Curve, Internal medicine, Stress studies, Cardiology, Residual activity, Medicine, Radiology, Nuclear Medicine and imaging, Cardiology and Cardiovascular Medicine, business, education, Stress study, circulatory and respiratory physiology
Abstract

13N-ammonia and 18F-flurpiridaz require longer delays between rest and stress studies to allow for decay, lowering clinical throughput. In this study, we investigated the impact of residual subtraction on MBF and MFR estimates, as well as its effects on diagnostic accuracy. We retrospectively analyzed 63 patients who underwent a dynamic ammonia rest/stress study and 231 patients from the flurpiridaz 301 trial. Residual subtraction was performed by subtracting the mean pre-injection activity in each sampled region from that region’s time activity curve. Corrected and uncorrected MBF and MFR were analyzed. Diagnostic accuracy was compared to quantitative coronary angiograms (QCA) for the flurpiridaz population. With delays between injections above 3 half-lives, and a doubled stress dose, residual activity did not meaningfully increase ammonia MBF (

Published
2021

9. Effect of iterations and time of flight on normal distributions of 82Rb PET relative perfusion and myocardial blood flow

Author

Jonathan B. Moody, Venkatesh L. Murthy, Jennifer M. Renaud, Liliana Arida-Moody, Edward P. Ficaro, Alexis Poitrasson-Rivière, and Tomoe Hagio

Subjects
Series (mathematics), Blood pool, business.industry, Blood flow, Iterative reconstruction, Normal distribution, Time of flight, Polar, Medicine, Radiology, Nuclear Medicine and imaging, Cardiology and Cardiovascular Medicine, business, Perfusion, Biomedical engineering
Abstract

As clinical use of myocardial blood flow (MBF) increases, dynamic series are becoming part of the typical workflow. The methods and parameters used to reconstruct these series require investigation to ensure accurate quantification. Fifty-nine rest/stress dynamic 82Rb PET studies, acquired on a Biograph mCT, from a combination of normal volunteers and low-likelihood patients were reconstructed with and without time of flight (TOF) for varying iterations and processed to obtain relative perfusion and MBF polar maps. Regional values from mean polar maps were fit to a linear mixed-effect model to quantify convergence and select the optimal number of iterations. TOF reconstructions converged faster and yielded more uniform relative perfusion polar maps. However, the stress MBF distribution for TOF reconstructions was more heterogeneous, with a higher-intensity septal wall. This phenomenon requires further investigation, with right ventricle blood pool spillover possibly having an effect. Optimal reconstructions were defined as 5-iteration non-TOF (24-subset) reconstructions and 3-iteration TOF (21-subset) reconstructions. Optimal cardiac reconstructions were identified for non-TOF and TOF reconstructions of dynamic series. TOF reconstruction presents as the more accurate method, given the more uniform relative perfusion distribution.

Published
2021

10. Myocardial flow reserve estimation with contemporary CZT-SPECT and 99mTc-tracers lacks precision for routine clinical application

Author

Tomoe Hagio, Venkatesh L. Murthy, Alexis Poitrasson-Rivière, Jennifer M. Renaud, Liliana Arida-Moody, Edward P. Ficaro, and Jonathan B. Moody

Subjects
Myocardial perfusion imaging, medicine.diagnostic_test, business.industry, medicine, Coronary flow reserve, Radiology, Nuclear Medicine and imaging, Repeatability, Cardiology and Cardiovascular Medicine, Nuclear medicine, business, Clinical risk factor
Abstract

PET myocardial flow reserve (MFR) has established diagnostic and prognostic value. Technological advances have now enabled SPECT MFR quantification. We investigated whether SPECT MFR precision is sufficient for clinical categorization of patients. Validation studies vs invasive flow measurements and PET MFR were reviewed to determine global SPECT MFR thresholds. Studies vs PET and a SPECT MFR repeatability study were used to establish imprecision in SPECT MFR measurements as the standard deviation of the difference between SPECT and PET MFR, or test-retest SPECT MFR. Simulations were used to evaluate the impact of SPECT MFR imprecision on confidence of clinically relevant categorization. Based on validation studies, the typical PET MFR categories were used for SPECT MFR classification ( 2.0). Imprecision vs PET MFR ranged from 0.556 to 0.829, and test-retest imprecision was 0.781-0.878. Simulations showed correct classification of up to only 34% of patients when 1.5 ≤ true MFR ≤ 2.0. Categorization with high confidence (> 80%) was only achieved for extreme MFR values ( 2.5), with correct classification in only 15% of patients in a typical lab with MFR of 1.8 ± 0.5. Current SPECT-derived estimates of MFR lack precision and require further optimization for clinical risk stratification.

Published
2021

11. Does quantification of [11C]meta-hydroxyephedrine and [13N]ammonia kinetics improve risk stratification in ischemic cardiomyopathy

Author

Aaryn Lavallee, Jason G.E. Zelt, Benjamin H. Rotstein, Rob S. Beanlands, Jennifer M. Renaud, Nicole Kaps, Jean Z. Wang, James A. Fallavollita, Robert A. deKemp, and John M. Canty

Subjects
medicine.medical_specialty, Sympathetic nervous system, Ejection fraction, Ischemic cardiomyopathy, medicine.diagnostic_test, business.industry, Sudden cardiac arrest, Blood flow, medicine.disease, medicine.anatomical_structure, Positron emission tomography, Internal medicine, Heart failure, medicine, Cardiology, Radiology, Nuclear Medicine and imaging, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Perfusion
Abstract

In ischemic cardiomyopathy patients, cardiac sympathetic nervous system dysfunction is a predictor of sudden cardiac arrest (SCA). This study compared abnormal innervation and perfusion measured by [11C]meta-hydroxyephedrine (HED) vs [13N]ammonia (NH3), conventional uptake vs parametric tracer analysis, and their SCA risk discrimination. This is a sub-study analysis of the prospective PAREPET trial, which followed ischemic cardiomyopathy patients with reduced left ventricular ejection fraction (LVEF ≤ 35%) for events of SCA. Using n = 174 paired dynamic HED and NH3 positron emission tomography (PET) scans, regional defect scores (%LV extent × severity) were calculated using HED and NH3 uptake, as well as HED distribution volume and NH3 myocardial blood flow by kinetic modeling. During 4.1 years follow-up, there were 27 SCA events. HED defects were larger than NH3, especially in the lowest tertile of perfusion abnormality (P < .001). Parametric defects were larger than their respective tracer uptake defects (P < .001). SCA risk discrimination was not significantly improved with parametric or uptake mismatch (AUC = 0.73 or 0.70) compared to HED uptake defect scores (AUC = 0.67). Quantification of HED distribution volume and NH3 myocardial blood flow produced larger defects than their respective measures of tracer uptake, but did not lead to improved SCA risk stratification vs HED uptake alone.

Published
2021

12. Effects of two patient-specific dosing protocols on measurement of myocardial blood flow with 3D 82Rb cardiac PET

Author

Anne M. Smith, Venkatesh L. Murthy, Edward P. Ficaro, Jennifer M. Renaud, Tomoe Hagio, Jonathan B. Moody, Liliana Arida-Moody, and Alexis Poitrasson-Rivière

Subjects
medicine.medical_specialty, Ejection fraction, business.industry, General Medicine, Blood flow, Patient specific, medicine.disease, 030218 nuclear medicine & medical imaging, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Cardiac PET, 030220 oncology & carcinogenesis, Internal medicine, medicine, Cardiology, Radiology, Nuclear Medicine and imaging, Dosing, business, Adverse effect, Perfusion
Abstract

Clinical measurement of myocardial blood flow (MBF) has emerged as an important component of routine PET-CT assessment of myocardial perfusion in patients with known or suspected coronary artery disease. Although multiple society guidelines recommend patient-specific dosing, there is a lack of studies evaluating the efficacy of patient-specific dosing for quantitative MBF accuracy. Two patient-specific dosing protocols (weight- and BMI-adjusted) were retrospectively evaluated in 435 consecutive clinical patients referred for PET myocardial perfusion assessment. MBF was estimated at rest and after regadenoson-induced hyperemia. The effect of dosing protocol on dose reduction, PET scanner saturation, relative perfusion, and image quality was compared. The effect of PET saturation on the accuracy of MBF and myocardial flow reserve (MFR) in remote myocardium was assessed with multivariable linear regression. BMI-adjusted dosing was associated with lower administered 82Rb activities (1036.0 ± 274 vs. 1147 ± 274 MBq, p = 0.003) and lower PET scanner saturation incidence (28 vs. 38%, p = 0.006) and severity (median saturation severity index 0.219 ± 0.33 vs. 0.397 ± 0.59%, p = 0.018) compared to weight-adjusted dosing. PET saturation that occurred with either dosing protocol was moderate and resulted in modest remote MBF and MFR biases ranging from 2 to 9% after adjusting for patient age, sex, BMI, rate-pressure product, and LV ejection fraction. No adverse effects of BMI dose adjustment were observed in relative perfusion assessment or image quality. Patient-specific dosing according to BMI is an effective method for guideline-directed dose reduction while maintaining image quality and accuracy for routine MBF and MFR quantification.

Published
2021

13. Internal validation of myocardial flow reserve PET imaging using stress/rest myocardial activity ratios with Rb-82 and N-13-ammonia

Author

Daniel Juneau, Terrence D. Ruddy, Nicole Kaps, Robert A. deKemp, Jennifer M. Renaud, Kai Yi Wu, Rob S. Beanlands, and Jason Yao

Subjects
Male, Dynamic imaging, Flow (psychology), Coronary Artery Disease, 030204 cardiovascular system & hematology, 030218 nuclear medicine & medical imaging, Stress (mechanics), 03 medical and health sciences, Imaging, Three-Dimensional, 0302 clinical medicine, Ammonia, Positron Emission Tomography Computed Tomography, Rest (finance), Image Processing, Computer-Assisted, Pressure, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Aged, Retrospective Studies, Tomography, Emission-Computed, Single-Photon, Nitrogen Radioisotopes, business.industry, Hemodynamics, Myocardial Perfusion Imaging, Area under the curve, Reproducibility of Results, Pet imaging, Middle Aged, Prognosis, Fractional Flow Reserve, Myocardial, Dipyridamole, Kinetics, ROC Curve, Cardiac PET, Area Under Curve, Positron-Emission Tomography, Exercise Test, Female, Stress, Mechanical, Cardiology and Cardiovascular Medicine, business, Nuclear medicine, Rubidium Radioisotopes, medicine.drug
Abstract

Myocardial flow reserve (MFR) measurement provides incremental diagnostic and prognostic information. The objective of the current study was to investigate the application of a simplified model for the estimation of MFR using only the stress/rest myocardial activity ratio (MAR) in patients undergoing rest–stress cardiac PET MPI. Rest and dipyridamole stress dynamic PET imaging was performed in consecutive patients using 82Rb or 13NH3 (n = 250 each). Reference standard MFR was quantified using a standard one-tissue compartment model. Stress/rest myocardial activity ratio (MAR) was calculated using the LV-mean activity from 2 to 6 minutes post-injection. Simplified estimates of MFR (MFREST) were then calculated using an inverse power function. For 13NH3, there was good correlation between MFR and MFREST values (R = 0.63), with similar results for 82Rb (R = 0.73). There was no bias in the MFREST values with either tracer. The overall diagnostic performance of MFREST for detection of MFR

Published
2021

14. Quantitative clinical nuclear cardiology, part 2: Evolving/emerging applications

Author

Robert Jh. Miller, Piotr J. Slomka, Jennifer M. Renaud, Jonathan B. Moody, Edward P. Ficaro, and Ernest V. Garcia

Subjects
medicine.medical_specialty, Single Photon Emission Computed Tomography Computed Tomography, Heart Diseases, Cardiology, 030204 cardiovascular system & hematology, Multimodal Imaging, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Continuing medical education, Internal medicine, Image Processing, Computer-Assisted, Humans, Ventricular Function, Medicine, Radiology, Nuclear Medicine and imaging, In patient, medicine.diagnostic_test, Ventricular function, business.industry, Myocardial Perfusion Imaging, Imaging analysis, Cardiac amyloidosis, Positron emission tomography, Microcalcification, Nuclear Medicine, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Emission computed tomography
Abstract

Quantitative analysis has been applied extensively to image processing and interpretation in nuclear cardiology to improve disease diagnosis and risk stratification. This is Part 2 of a two-part continuing medical education article, which will review the potential clinical role for emerging quantitative analysis tools. The article will describe advanced methods for quantifying dyssynchrony, ventricular function and perfusion, and hybrid imaging analysis. This article discusses evolving methods to measure myocardial blood flow with positron emission tomography and single-photon emission computed tomography. Novel quantitative assessments of myocardial viability, microcalcification and in patients with cardiac sarcoidosis and cardiac amyloidosis will also be described. Lastly, we will review the potential role for artificial intelligence to improve image analysis, disease diagnosis, and risk prediction. The potential clinical role for all these novel techniques will be highlighted as well as methods to optimize their implementation. (J Nucl Cardiol 2020).

Published
2020

15. Reproducible Quantification of Regional Sympathetic Denervation with [11C]meta-Hydroxyephedrine PET Imaging

Author

James A. Fallavollita, Jean Z. Wang, Jonathan B. Moody, Jennifer M. Renaud, Aaryn Lavallee, Kai Yi Wu, Jason G.E. Zelt, John M. Canty, Nicole Kaps, Robert A. deKemp, Rob S. Beanlands, and Deron Britt

Subjects
Denervation, medicine.medical_specialty, Reproducibility, Ischemic cardiomyopathy, Ejection fraction, business.industry, Intraclass correlation, Sudden cardiac arrest, Repeatability, 030204 cardiovascular system & hematology, medicine.disease, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Heart failure, Cardiology, Medicine, Radiology, Nuclear Medicine and imaging, medicine.symptom, Cardiology and Cardiovascular Medicine, business
Abstract

Regional cardiac sympathetic denervation is predictive of sudden cardiac arrest in patients with ischemic cardiomyopathy. The reproducibility of denervation scores between automated software programs has not been evaluated. This study seeks to (1) compare the inter-rater reliability of regional denervation measurements using two analysis programs: FlowQuant® and Corridor4DM®; (2) evaluate test–retest repeatability of regional denervation scores. N = 190 dynamic [11C]meta-hydroxyephedrine (HED) PET scans were reviewed from the PAREPET trial in ischemic cardiomyopathy patients with reduced left ventricular ejection fraction(LVEF ≤ 35%). N = 12 scans were excluded due to non-diagnostic quality. N = 178 scans were analyzed using FlowQuant and Corridor4DM software, each by two observers. Test–retest scans from N = 20 patients with stable heart failure were utilized for test–retest analysis. Denervation scores were defined as extent × severity of relative uptake defects in LV regions with

Published
2020

16. Site qualification and clinical interpretation standards for 99mTc-SPECT perfusion imaging in a multi-center study of MITNEC (Medical Imaging Trials Network of Canada)

Author

Therese Heinonen, Manuja Premaratne, Robert A. deKemp, François Harel, Jean-Claude Tardif, Terrence D. Ruddy, Marie Claude Villeneuve, Vincent Finnerty, and Jennifer M. Renaud

Subjects
Ejection fraction, medicine.diagnostic_test, business.industry, Image quality, Perfusion scanning, 030204 cardiovascular system & hematology, Single-photon emission computed tomography, Imaging phantom, 030218 nuclear medicine & medical imaging, SSS, 03 medical and health sciences, 0302 clinical medicine, Medical imaging, Medicine, Radiology, Nuclear Medicine and imaging, Cardiology and Cardiovascular Medicine, business, Nuclear medicine, Technetium-99m
Abstract

Qualification and interpretation standards are essential for establishing 99mTc-SPECT MPI accuracy vs. alternative modalities. Rest–stress 99mTc-SPECT phantom scans were acquired on 35 cameras. LV defects were quantified with summed stress (SSS) and difference scores (SDS) at 2 core labs. SDS ≥ 2 in the right coronary artery (RCA) was the qualifying standard. Twenty rest (R)–stress (S) patient images were acquired on qualified cameras and interpreted by core labs. Global scoring differences > 3 between labs or discordant clinical interpretations underwent review. Scoring, interpretation, image quality, and diagnostic parameter agreement were assessed. Phantom scans: visual scoring confirmed RCA-ischemia on all cameras. Regional SSS, SDS agreement was moderate to very good: ICC-r = 0.57, 0.84. Patient scans: 90% of global SSS, 85% of SDS differences were ≤ 3. Regional SSS, SDS agreement: ICC-r = 0.87, 0.86, and global abnormal (SSS ≥ 4) and ischemic (SDS ≥ 2) interpretation: ICC-r = 0.90 were excellent. Clinical interpretation agreement was 100% following review. Image quality agreement was 70%. Automated metrics also agreed: ischemic total perfusion deficit ICC-r = 0.75, reversible perfusion defect, transient ischemic dilation, and S-R LV ejection fraction ICC-r ≥ 0.90. Quantitative scoring and interpretation of scans were highly repeatable with site qualification and clinical interpretation standardization, indicating that dual-core lab interpretation is appropriate to determine 99mTc-SPECT MPI accuracy.

Published
2020

17. Cherenkov Telescope Array : the World’s largest VHE gamma-ray observatory

Author

Roberta Zanin, H. Abdalla, H. Abe, S. Abe, A. Abusleme, F. Acero, A. Acharyya, V. Acin Portella, K. Ackley, R. Adam, C. Adams, S.S. Adhikari, I. Aguado Ruesga, I. Agudo, R. Aguilera, A. Aguirre Santaella, F. Aharonian, A. Alberdi, R. Alfaro, J. Alfaro, C. Alispach, R. Aloisio, R. Alves Batista, J.P. Amans, L. Amati, E. Amato, L. Ambrogi, G. Ambrosi, M. Ambrosio, R. Ammendola, J. Anderson, M. Anduze, E.O. Anguner, L.A. Antonelli, V. Antonuccio, P. Antoranz, R. Anutarawiramkul, J. Aragunde Gutierrez, C. Aramo, A. Araudo, M. Araya, A. Arbet Engels, C. Arcaro, V. Arendt, C. Armand, T. Armstrong, F. Arqueros, L. Arrabito, B. Arsioli, M. Artero, K. Asano, Y. Ascasibar, J. Aschersleben, M. Ashley, P. Attina, P. Aubert, C. B. Singh, D. Baack, A. Babic, M. Backes, V. Baena, S. Bajtlik, A. Baktash, C. Balazs, M. Balbo, O. Ballester, J. Ballet, B. Balmaverde, A. Bamba, R. Bandiera, A. Baquero Larriva, P. Barai, C. Barbier, V. Barbosa Martins, M. Barcelo, M. Barkov, M. Barnard, L. Baroncelli, U. Barres de Almeida, J.A. Barrio, D. Bastieri, P.I. Batista, I. Batkovic, C. Bauer, R. Bautista González, J. Baxter, U. Becciani, J. Becerra González, Y. Becherini, G. Beck, J. Becker Tjus, W. Bednarek, A. Belfiore, L. Bellizzi, R. Belmont, W. Benbow, D. Berge, E. Bernardini, M.I. Bernardos, K. Bernlöhr, A. Berti, M. Berton, B. Bertucci, V. Beshley, N. Bhatt, S. Bhattacharyya, W. Bhattacharyya, B. Y. Bi, G. Bicknell, N. Biederbeck, C. Bigongiari, A. Biland, R. Bird, E. Bissaldi, J. Biteau, M. Bitossi, O. Blanch, M. Blank, J. Blazek, J. Bobin, C. Boccato, F. Bocchino, C. Boehm, M. Bohacova, C. Boisson, J. Boix, J.P. Bolle, J. Bolmont, G. Bonanno, C. Bonavolontà, L. Bonneau Arbeletche, G. Bonnoli, P. Bordas, J. Borkowski, R. Bose, D. Bose, Z. Bosnjak, E. Bottacini, Markus Böttcher, M.T. Botticella, C. Boutonnet, F. Bouyjou, V. Bozhilov, E. Bozzo, L. Brahimi, C. Braiding, S. Brau Nogue, S. Breen, J. Bregeon, M. Breuhaus, A. Brill, W. Brisken, E. Brocato, A.M. Brown, K. Brügge, P. Brun, F. Brun, L. Brunetti, G. Brunetti, P. Bruno, A. Bruno, A. Bruzzese, N. Bucciantini, J. H. Buckley, R. Bühler, A. Bulgarelli, T. Bulik, M. Bünning, M. Bunse, M. Burton, A. Burtovoi, M. Buscemi, S. Buschjager, G. Busetto, J. Buss, K. Byrum, A. Caccianiga, F. Cadoux, A. Calanducci, C. Calderon, J. Calvo Tovar, R. A. Cameron, P. Campana, R. Canestrari, F. Cangemi, B. Cantlay, M. Capalbi, M. Capasso, M. Cappi, A. Caproni, R. Capuzzo Dolcetta, P. Caraveo, V. Cárdenas, L. Cardiel, M. Cardillo, C. Carlile, S. Caroff, R. Carosi, A. Carosi, E. Carquin, M. Carrere, J.M. Casandjian, S. Casanova, F. Cassol, F. Catalani, O. Catalano, D. Cauz, A. Ceccanti, C. Celestino Silva, K. Cerny, M. Cerruti, E. Chabanne, P. Chadwick, Y. Chai, P. Chambery, C. Champion, S. Chaty, A. Chen, K. Cheng, M. Chernyakova, G. Chiaro, A. Chiavassa, M. Chikawa, V.R. Chitnis, J. Chudoba, L. Chytka, S. Cikota, A. Circiello, P. Clark, M. Colak, E. Colombo, S. Colonges, A. Comastri, A. Compagnino, V. Conforti, E. Congiu, R. Coniglione, J. Conrad, F. Conte, J.L. Contreras, P. Coppi, R. Cornat, J. Coronado Blazquez, J. Cortina, A. Costa, H. Costantini, G. Cotter, B. Courty, S. Covino, S. Crestan, P. Cristofari, R. Crocker, J. Croston, K. Cubuk, O. Cuevas, X. Cui, G. Cusumano, S. Cutini, G. D'Amico, F. D'Ammando, P. D'Avanzo, P. Da Vela, M. Dadina, S. Dai, M. Dalchenko, M. Dall'Ora, M.K. Daniel, J. Dauguet, I. Davids, J. Davies, B. Dawson, A. De Angelis, A.E. de Araujo Carvalho, M. de Bony de Lavergne, G. De Cesare, F. de Frondat, I. de la Calle, E. de Gouveia Dal Pino, B. De Lotto, A. De Luca, D. De Martino, M. de Naurois, E. de Ona Wilhelmi, F. De Palma Persio, N. De Simone, V. de Souza Valle, E. Delagnes, G. Deleglise Reznicek, C. Delgado, A.G. Delgado Giler, J. Delgado Mengual Valle, Domenico Della Volpe, D. Depaoli, J. Devin, T. Di Girolamo, C. Di Giulio Pierro, L. Di Venere, C. Díaz, C. Dib, S. Diebold, S. Digel, A. Djannati Atai, J. Djuvsland, A. Dmytriiev, K. Docher, A. Domínguez, D. Dominis Prester, A. Donini, D. Dorner, M. Doro, Rita Cassia dos Anjos, J.L. Dournaux, T. Downes, G. Drake, H. Drass, D. Dravins, C. Duangchan, A. Duara, G. Dubus, L. Ducci, C. Duffy, D. Dumora, K. Dundas Mora, A. Durkalec, V.V. Dwarkadas, J. Ebr, C. Eckner, J. Eder, E. Edy, K. Egberts, S. Einecke, C. Eleftheriadis, D. Elsässer, G. Emery, D. Emmanoulopoulos, J.P. Ernenwein, M. Errando, P. Escarate, J. Escudero, C. Espinoza, S. Ettori, A. Eungwanichayapant, P. Evans, C. Evoli, M. Fairbairn, D. Falceta Goncalves, A. Falcone, V. Fallah Ramazanı, R. Falomo, K. Farakos, G. Fasola, A. Fattorini, Y. Favre, R. Fedora, E. Fedorova, K. Feijen, Q. Feng, G. Ferrand, G. Ferrara, O. Ferreira, M. Fesquet, E. Fiandrini, A. Fiasson, M. Filipovic, D. Fink, J.P. Finley, V. Fioretti, D.F.G. Fiorillo, M. Fiorini, S. Flis, H. Flores, L. Foffano, C. Fohr, M.V. Fonseca, L. Font, G. Fontaine, O. Fornieri, P. Fortin, L. Fortson, N. Fouque, B. Fraga, A. Franceschini, F.J. Franco, L. Freixas Coromina, L. Fresnillo, D. Fugazza, Y. Fujita, S. Fukami, Y. Fukazawa, D. Fulla, S. Funk, A. Furniss, S. Gabici, D. Gaggero, G. Galanti, P. Galdemard, Y. A. Gallant, D. Galloway, S. Gallozzi, V. Gammaldi, R. Garcia, L. E. García-Muñoz, E. Garcia Lopez, F. Gargano, C. Gargano, S. Garozzo, D. Gascon, T. Gasparetto, D. Gasparrini, H. Gasparyan, M. Gaug, N. Geffroy, A. Gent, S. Germani, A. Ghalumyan, A. Ghedina, G. Ghirlanda, F. Gianotti, S. Giarrusso, M. Giarrusso, G. Giavitto, B. Giebels, N. Giglietto, V. Gika, F. Gillardo, R. Gimenes, F. Giordano, E. Giro, M. Giroletti, Andrea Giuliani, M. Gjaja, J.F. Glicenstein, P. Gliwny, H. Goksu, P. Goldoni, J.L. Gomez, M.M. Gonzalez, Juan Manuel Gonzalez, K.S. Gothe, D. Gotz Coelho, T. Grabarczyk, R. Graciani, P. Grandi, G. Grasseau, D. Grasso, D. Green, J. Green, T. Greenshaw, P. Grespan, A. Grillo, M.H. Grondin, J. Grube, V. Guarino, B. Guest, O. Gueta, M. Günduz, S. Gunji, G. Gyuk, J. Hackfeld, D. Hadasch, L. Hagge, A. Hahn, J.E. Hajlaoui, A. Halim, P. Hamal, W. Hanlon, Y. Harada, M.J. Hardcastle, M. Harvey Collado, T. Haubold, A. Haupt, M. Havelka, K. Hayashi, M. Hayashida, H. He, L. Heckmann, M. Heller, F. Henault, Gilles Henri, G. Hermann, S. Hernández Cadena, J. Herrera Llorente, O. Hervet, J. Hinton, A. Hiramatsu, K. Hirotani, B. Hnatyk, R. Hnatyk, J.K. Hoang, D. H.H. Hoffmann, C. Hoischen, J. Holder, M. Holler, B. Hona, D. Horan, Dieter Horns, P. Horvath, J. Houles, M. Hrabovsky, D. Hrupec, Y. Huang, J.‑M. Huet, G. Hughes, G. Hull, T.B. Humensky, M. Hütten, M. Iarlori, J.M. Illa, R. Imazawa, T. Inada, F. Incardona, A. Ingallinera, S. Inoue, T. Inoue, Y. Inoue, F. Iocco, K. Ioka, M. Ionica, S. Iovenitti, A. Iriarte, K. Ishio, W. Ishizaki, Y. Iwamura, J. Jacquemier, M. Jacquemont, M. Jamrozy, P. Janecek, F. Jankowsky, A. JardinBlicq, C. Jarnot, P. Jean Martínez, L. Jocou, N. Jordana, M. Josselin, I. JungRichardt, F.J.P.A. Junqueira, C. Juramy Gilles, P. Kaaret, L.H.S. Kadowaki, M. Kagaya, R. Kankanyan, D. Kantzas, V. Karas, A. Karastergiou, S. Karkar, J. Kasperek, H. Katagiri, J. Kataoka, K. Katarzynski, S. Katsuda, N. Kawanaka, D. Kazanas, D. Kerszberg, B. Khélifi, M.C. Kherlakian, T.P. Kian, D.B. Kieda, T. Kihm, S. Kim, S. Kisaka, R. Kissmann, R. Kleijwegt, G. Kluge, W. Kluźniak, J. Knapp, A. Kobakhidze, Y. Kobayashi, B. Koch, J. Kocot, K. Kohri, N. Komin, A. Kong, K. Kosack, F. Krack, M. Krause, F. Krennrich, H. Kubo, V. N. Kudryavtsev, S. Kunwar, J. Kushida, P. Kushwaha, Barbera Parola, G. La Rosa, R. Lahmann, A. Lamastra, M. Landoni, D. Landriu, R.G. Lang, J. Lapington, P. Laporte, P. Lason, J. Lasuik, J. Lazendic Galloway, T. Le Flour, P. Le Sidaner, S. Leach, S.H. Lee, W.H. Lee, S. Lee Oliveira, A. Lemiere, M. Lemoine Goumard, J.P. Lenain, F. Leone, V. Leray, G. Leto, F. Leuschner, R. Lindemann, E. Lindfors, L. Linhoff, I. Liodakis, A. Lipniacka, M. Lobo, Thomas Lohse, S. Lombardi, A. Lopez, M. Lopez, R. Lopez Coto, F. Louis, M. Louys, F. Lucarelli, H. Ludwig Boudi, P.L. Luque Escamilla, M.C. Maccarone, E. Mach, A.J. Maciejewski, J. Mackey, P. Maeght, C. Maggio, G. Maier, P. Majumdar, M. Makariev, M. Mallamaci, R. Malta Nunes de Almeida, D. Malyshev, D. Mandat, G. Maneva, M. Manganaro, P. Manigot, K. Mannheim, N. Maragos, D. Marano, M. Marconi, A. Marcowith, M. Marculewicz, B. Marcun, J. Marin, N. Marinello, P. Marinos, S. Markoff, P. Marquez, G. Marsella, J. M. Martin, P. G. Martin, M. Martinez, G. Martinez, O. Martinez, H. Martinez Huerta, C. Marty, R. Marx, N. Masetti, P. Massimino, H. Matsumoto, N. Matthews, G. Maurin, W. Max Moerbeck, N. Maxted, M.N. Mazziotta, S.M. Mazzola, J.D. Mbarubucyeye, L. Mc Comb, I. McHardy, S. McKeague, S. McMuldroch, E. Medina, D. Medina Miranda, A. Melandri, C. Melioli, D. Melkumyan, S. Menchiari, S. Mereghetti, G. Merino Arevalo, E. Mestre, J.L. Meunier, T. Meures, S. Micanovic, M. Miceli, M. Michailidis, J. Michalowski, T. Miener, I. Mievre, J. D. Miller, T. Mineo, M. Minev, J.M. Miranda, A. Mitchell, T. Mizuno, B. A. Mode, R. Moderski, L. Mohrmann, E. Molinari, T. Montaruli, I. Monteiro, C. Moore, A. Moralejo, D. Morcuende Parrilla, E. Moretti, K. Mori, P. Moriarty, K. Morik, P. Morris, A. Morselli, K. Mosshammer, R. Mukherjee, J. Muller, C. Mundell, J. Mundet, T. Murach, A. Muraczewski, H. Muraishi, I. Musella, A. Musumarra, A. Nagai, S. Nagataki, T. Naito, T. Nakamori, K. Nakashima, K. Nakayama, N. Nakhjiri, G. Naletto, D. Naumann, L. Nava, M.A. Nawaz, H. Ndiyavala, D. Neise, L. Nellen, R. Nemmen, N. Neyroud, K. Ngernphat, T. Nguyen Trung, L. Nicastro, L. Nickel, J. Niemiec, D. Nieto, C. Nigro, M. Nikołajuk, D. Ninci, K. Noda, Y. Nogami, S. Nolan, R. P. Norris, D. Nosek, M. Nöthe, V. Novotny, S. Nozaki, F. Nunio, P. O'Brien, K. Obara, Y. Ohira, M. Ohishi, S. Ohm, T. Oka, N. Okazaki, A. Okumura, C. Oliver, G. Olivera, B. Olmi, M. Orienti, R. Orito, M. Orlandini, E. Orlando, J.P. Osborne, M. Ostrowski, N. Otte, E. Ovcharov, E. Owen, I. Oya, A. Ozieblo, M. Padovani, A. Pagliaro, A. Paizis, M. Palatiello, M. Palatka, E. Palazzi, J.‑L. Panazol, D. Paneque, S. Panny, Francesca Romana Pantaleo, M. Panter, M. Paolillo, A. Papitto, A. Paravac, J.M. Paredes, G. Pareschi, N. Parmiggiani, R.D. Parsons, P. Paśko, S. R. Patel, B. Patricelli, L. Pavletic, S. Pavy, A. Peer, M. Pecimotika, M.G. Pellegriti, P. Peñil Del Campo, A. Pepato, S. Perard, C. Perennes, M. Peresano, A. Perez Aguilera, J. Perez Romero, M.A. Perez Torres, M. Persic, P. O. Petrucci, O. Petruk, B. Peyaud, K. Pfrang, E. Pian, P. Piatteli, E. Pietropaolo, R. Pillera, D. Pimentel, F. Pintore, C. Pio Garcia, G. Pirola, F. Piron, S. Pita, M. Pohl, V. Poireau, A. Pollo, M. Polo, C. Pongkitivanichkul, J. Porthault, J. Powell, D. Pozo, R.R. Prado, E. Prandini, J. Prast, K. Pressard, G. Principe, N. Produit, D. Prokhorov, H. Prokoph, H. Przybilski, E. Pueschel, G. Pühlhofer, I. Puljak, M.L. Pumo, M. Punch, F. Queiroz, J. Quinn, A. Quirrenbach, P.J. Rajda, R. Rando, S. Razzaque, S. Recchia, P. Reichherzer, O. Reimer, A. Reisenegger, Q. Remy, M. Renaud, T. Reposeur, B. Reville, J.M. Reymond, J. Reynolds, D. Ribeiro, M. Ribo, G. Richards, J. Rico, F. Rieger, L. Riitano, M. Riquelme, D. Riquelme, S. Rivoire, V. Rizi, E. Roache, M. Roche, J. Rodriguez, G. Rodriguez Fernandez, J.C. Rodriguez Ramirez, J.J. Rodriguez Vazquez, G. Rojas, P. Romano, G. Romeo Lobato, C. Romoli, M. Roncadelli, J. Rosado, A. Rosales de Leon, G. Rowell, A. Rugliancich, J.E. Ruiz del Mazo, C. Rulten, C. Russell, F. Russo Hatlen, S. Safi Harb, L. Saha, V. Sahakian, S. Sailer, T. Saito, N. Sakaki, S. Sakurai, G. Salina, H. Salzmann, D. Sanchez, H. Sandaker, A. Sandoval, P. Sangiorgi, M. Sanguillon, H. Sano, M. Santander, A. Santangelo, R. Santos Lima, A. Sanuy, L. Sapozhnikov, T. Saric, S. Sarkar, H. Sasaki, N. Sasaki, Y. Sato, F.G. Saturni, M. Sawada, J. Schaefer, A. Scherer, J. Scherpenberg, P. Schipani, B. Schleicher, J. Schmoll, M. Schneider, H. Schoorlemmer, P. Schovanek, F. Schussler, B. Schwab, U. Schwanke, J. Schwarz, E. Sciacca, S. Scuderi, M. Seglar Arroyo, I. Seitenzahl, D. Semikoz, O. Sergijenko, J.E. Serna Franco, Karol Seweryn, V. Sguera, A. Shalchi, R.Y. Shang, P. Sharma, L. Sidoli, J. Sieiro, H. Siejkowski, A. Sillanpaa, B.B. Singh, K.K. Singh, A. Sinha, C. Siqueira, J. Sitarek, P. Sizun, V. Sliusar, D. Sobczynska, R.W. Sobrinho, H. Sol, G. Sottile, H. Spackman, S. Spencer, G. Spengler, D. Spiga, W. Springer, A. Stamerra, S. Stanic, R. Starling, Ł. Stawarz, Stanislav Stefanik, C. Stegmann, A. Steiner, S. Steinmassl, C. Stella, R. Sternberger, M. Sterzel, C. Stevens, B. Stevenson, T. Stolarczyk, G. Stratta, U. Straumann, J. Striskovic, M. Strzys, R. Stuik, M. Suchenek, Y. Sunada, Tiina Suomijarvi, T. Suric, H. Suzuki, P. Swierk, T. Szepieniec, K. Tachihara, G. Tagliaferri, H. Tajima, N. Tajima, D. Tak, H. Takahashi, M. Takahashi, J. Takata, R. Takeishi, T. Tam, M. Tanaka, T. Tanaka, S. Tanaka, M. Tavani, F. Tavecchio, T. Tavernier, A. Russ Taylor, L.A. Tejedor, P. Temnikov, K. Terauchi, J.C. Terrazas, R. Terrier, T. Terzic, M. Teshima, D. Thibaut, F. Thocquenne, W. Tian, L. Tibaldo, A. Tiengo, M. Tluczykont, C.J. Todero Peixoto, K. Toma, L. Tomankova, J. Tomastik, M. Tornikoski, D.F. Torres, E. Torresi, G. Tosti, L. Tosti, N. Tothill, F. Toussenel, G. Tovmassian, C. Trichard, M. Trifoglio, A. Trois, S. Truzzi, A. Tsiahina, B. Turk, A. Tutone, Y. Uchiyama, P. Utayarat, L. Vaclavek, M. Vacula, V. Vagelli, F. Vagnetti, J.A. Valdivia, M. Valentino, A. Valio, B. Vallage, P. Vallania Quispe, A.M. van den Berg, W. van Driel, C. van Eldik, C. van Rensburg, Brian van Soelen, J. Vandenbroucke, G. Vasileiadis, V. Vassiliev, M. Vazquez Acosta, M. Vecchi, A. Vega, J. Veh, P. Veitch, C. Venter, S. Ventura, S. Vercellone, V. Verguilov, G. Verna, S. Vernetto, V. Verzi, G.P. Vettolani, C. Veyssiere, I. Viale, A. Viana, N. Viaux, J. Vignatti, C.F. Vigorito, J. Villanueva, V. Vitale, V. Vittorini, V. Vodeb, N. Vogel, V. Voisin, S. Vorobiov, M. Vrastil, T. Vuillaume, S.J. Wagner, P. Wagner, K. Wakazono, S.P. Wakely, M. Ward, D. Warren, J. Watson, M. Wechakama, P. Wegner, A. Weinstein, C. Weniger, F. Werner, H. Wetteskind, M. L. White, A. Wierzcholska, S. Wiesand, R. Wijers, M. Wilkinson, M. Will, J. Williams, T. J. Williamson, A. Wolter, Y.W. Wong, M. Wood, T. Yamamoto, H. Yamamoto, Y. Yamane, R. Yamazaki, S. Yanagita, L. Yang, S. Yoo, T. Yoshida, T. Yoshikoshi, P. Yu, A. Yusafzai, Michael Zacharias, B. Zaldivar, L. Zampieri, R. Zanin, R. Zanmar Sanchez, D. Zaric, M. Zavrtanik, D. Zavrtanik, Andrzej Zdziarski, A. Zech, H. Zechlin, A. Zenin, A. Zerwekh, K. Ziętara, A. Zink, J. Ziolkowski, M. Zivec, A. Zmija, Współautorami artykułu są członkowie CTA Observatory, CTA Consortium i LST Collaboration w liczbie 1139, Astronomy, Research unit Nuclear & Hadron Physics, and Research unit Astroparticle Physics

Subjects
Physics, Observatory, Gamma ray, Astronomy
Abstract

Very-high Energy (VHE) gamma-ray astroparticle physics is a relatively young field, and observations over the past decade have surprisingly revealed almost two hundred VHE emitters which appear to act as cosmic particle accelerators. These sources are an important component of the Universe, influencing the evolution of stars and galaxies. At the same time, they also act as a probe of physics in the most extreme environments known - such as in supernova explosions, and around or after the merging of black holes and neutron stars. However, the existing experiments have provided exciting glimpses, but often falling short of supplying the full answer. A deeper understanding of the TeV sky requires a significant improvement in sensitivity at TeV energies, a wider energy coverage from tens of GeV to hundreds of TeV and a much better angular and energy resolution with respect to the currently running facilities. The next generation gamma-ray observatory, the Cherenkov Telescope Array Observatory (CTAO), is the answer to this need. In this talk I will present this upcoming observatory from its design to the construction, and its potential science exploitation. CTAO will allow the entire astronomical community to explore a new discovery space that will likely lead to paradigm-changing breakthroughs. In particular, CTA has an unprecedented sensitivity to short (sub-minute) timescale phenomena, placing it as a key instrument in the future of multi-messenger and multi-wavelength time domain astronomy. I will conclude the talk presenting the first scientific results obtained by the LST-1, the prototype of one CTAO telescope type - the Large-Sized Telescope, that is currently under commission., PoS: Proceedings of Science, 395, ISSN:1824-8039, Proceedings of 37th International Cosmic Ray Conference (ICRC2021)

Published
2022

18. The first days of type II-P core collapse supernovae in the gamma-ray range

Author

P Cristofari, A Marcowith, M Renaud, V V Dwarkadas, V Tatischeff, G Giacinti, E Peretti, and H Sol

Subjects
High Energy Astrophysical Phenomena (astro-ph.HE), Astrophysics::High Energy Astrophysical Phenomena, PROGENITOR, FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, BREAKOUT, COSMIC-RAYS, NONLINEAR PARTICLE-ACCELERATION, cosmic rays [Interstellar medium], REVERSE SHOCKS, Space and Planetary Science, RADIO-EMISSION, ABSORPTION, SPECTRA, Astrophysics::Solar and Stellar Astrophysics, DIFFUSIVE SHOCK ACCELERATION, REMNANT, Astrophysics - High Energy Astrophysical Phenomena, general [supernovae], Astrophysics::Galaxy Astrophysics, general [gamma-rays]
Abstract

Type II-P supernov\ae~(SNe), the most common core-collapse SNe type, result from the explosions of red supergiant stars. Their detection in the radio domain testifies of the presence of relativistic electrons, and shows that they are potentially efficient energetic particle accelerators. If hadrons can also be accelerated, these energetic particles are expected to interact with the surrounding medium to produce a gamma-ray signal even in the multi--TeV range. The intensity of this signal depends on various factors, but an essential one is the density of the circumstellar medium. Such a signal should however be limited by electron-positron pair production arising from the interaction of the gamma-ray photons with optical photons emitted by the supernova photosphere, which can potentially degrade the gamma-ray signal by over ten orders of magnitude in the first days/weeks following the explosion. We calculate the gamma-gamma opacity from a detailed modelling of the time evolution of the forward shock and supernova photosphere, taking a full account of the non-isotropy of the photon interactions. We discuss the time-dependent gamma-ray TeV emission from type II-P SNe as a function of the stellar progenitor radius and mass-loss rate, as well as the explosion energy and mass of the ejected material. We evaluate the detectability of the SNe with the next generation of Cherenkov telescopes. We find that, while most extragalactic events may be undetectable, type II-P SNe exploding in our Galaxy or in the Magellanic Clouds should be detected by gamma-ray observatories such as the upcoming Cherenkov Telescope Array., Comment: 9 pages, 8 figures, Accepted for publication in MNRAS

Published
2022
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21. Reliable quantification of myocardial sympathetic innervation and regional denervation using [11C]meta-hydroxyephedrine PET

Author

Lisa Mielniczuk, Robert A. deKemp, Jason G.E. Zelt, Aaryn Lavallee, Robert C. Miner, Tong Wang, Nicole Kaps, Vincent Dinculescu, Catherine Lapierre, Shin-Yee Chen, Rob S. Beanlands, Ian G. Burwash, Jennifer M. Renaud, Kai Yi Wu, Jean DaSilva, and James T. Thackeray

Subjects
Denervation, Volume of distribution, medicine.medical_specialty, Reproducibility, Ejection fraction, medicine.diagnostic_test, business.industry, General Medicine, Repeatability, Blood flow, medicine.disease, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Positron emission tomography, 030220 oncology & carcinogenesis, Internal medicine, Heart failure, medicine, Cardiology, Radiology, Nuclear Medicine and imaging, business
Abstract

Cardiac sympathetic nervous system (SNS) dysfunction is associated with poor prognosis in chronic heart failure patients. This study characterized the reproducibility and repeatability of [11C]meta-hydroxyephedrine (HED) positron emission tomography (PET) quantification of cardiac SNS innervation, regional denervation, and myocardial blood flow (MBF). Dynamic HED PET-CT scans were performed 47 ± 22 days apart in 20 patients with stable heart failure and reduced ejection fraction. Three observers, blinded to clinical data, used FlowQuant® to evaluate the test-retest repeatability and inter- and intra-observer reproducibility of HED tracer uptake and clearance rates to measure global (LV-mean) retention index (RI), volume of distribution (VT), and MBF. Values were also compared with and without regional partial-volume correction. Regional denervation was quantified as %LV defect size of values

Published
2019

22. 'Virtual' attenuation correction: improving stress myocardial perfusion SPECT imaging using deep learning

Author

Tomoe, Hagio, Alexis, Poitrasson-Rivière, Jonathan B, Moody, Jennifer M, Renaud, Liliana, Arida-Moody, Ravi V, Shah, Edward P, Ficaro, and Venkatesh L, Murthy

Subjects
Perfusion, Tomography, Emission-Computed, Single-Photon, Deep Learning, Image Processing, Computer-Assisted, Myocardial Perfusion Imaging, Humans, Coronary Artery Disease, Retrospective Studies
Abstract

Myocardial perfusion imaging (MPI) using single-photon emission computed tomography (SPECT) is widely used for coronary artery disease (CAD) evaluation. Although attenuation correction is recommended to diminish image artifacts and improve diagnostic accuracy, approximately 3/4ths of clinical MPI worldwide remains non-attenuation-corrected (NAC). In this work, we propose a novel deep learning (DL) algorithm to provide "virtual" DL attenuation-corrected (DLAC) perfusion polar maps solely from NAC data without concurrent computed tomography (CT) imaging or additional scans.SPECT MPI studies (N = 11,532) with paired NAC and CTAC images were retrospectively identified. A convolutional neural network-based DL algorithm was developed and trained on half of the population to predict DLAC polar maps from NAC polar maps. Total perfusion deficit (TPD) was evaluated for all polar maps. TPDs from NAC and DLAC polar maps were compared to CTAC TPDs in linear regression analysis. Moreover, receiver-operating characteristic analysis was performed on NAC, CTAC, and DLAC TPDs to predict obstructive CAD as diagnosed from invasive coronary angiography.DLAC TPDs exhibited significantly improved linear correlation (p 0.001) with CTAC (RThe proposed DL algorithm provided attenuation correction comparable to CTAC without the need for additional scans. Compared to conventional NAC perfusion imaging, DLAC significantly improved diagnostic accuracy.

Published
2021

23. Impact of residual subtraction on myocardial blood flow and reserve estimates from rapid dynamic PET protocols

Author

Alexis, Poitrasson-Rivière, Jonathan B, Moody, Jennifer M, Renaud, Tomoe, Hagio, Liliana, Arida-Moody, Christopher, Buckley, Richard L, Weinberg, Edward P, Ficaro, and Venkatesh L, Murthy

Subjects
Fractional Flow Reserve, Myocardial, Clinical Trials as Topic, Ammonia, Coronary Circulation, Positron-Emission Tomography, Myocardial Perfusion Imaging, Humans, Coronary Artery Disease, Retrospective Studies
Abstract

We retrospectively analyzed 63 patients who underwent a dynamic ammonia rest/stress study and 231 patients from the flurpiridaz 301 trial. Residual subtraction was performed by subtracting the mean pre-injection activity in each sampled region from that region's time activity curve. Corrected and uncorrected MBF and MFR were analyzed. Diagnostic accuracy was compared to quantitative coronary angiograms (QCA) for the flurpiridaz population.With delays between injections above 3 half-lives, and a doubled stress dose, residual activity did not meaningfully increase ammonia MBF ( 5%). For shorter injection delays, stress MBF was overestimated by 13.6% ± 5.0% (P .001). Residual activity had a large effect on flurpiridaz stress MBF, overestimating it by 37.9% ± 23.2% (P .001). Comparison to QCA showed a significant improvement in AUC with residual subtraction (from 0.748 to 0.831, P = .001). MFR yielded similar results.Accounting for residual activity has a marked impact on stress MBF and MFR and improves diagnostic accuracy relative to QCA.

Published
2021

24. TeV Emission of Galactic Plane Sources with HAWC and H.E.S.S

Author

Nicola Omodei, Sebastian Panny, A. Sandoval, Q. Piel, S. Raab, Arturo Iriarte, Kirsty Feijen, R. D. Parsons, Michael Newbold, J. Zorn, Michael Schneider, Fernando Garfias, D. Huber, Christo Venter, Jacek Niemiec, Arnaud Mares, Frank M. Rieger, Thomas Weisgarber, A. Dmytriiev, Olaf Reimer, A. Zech, E. Ruiz-Velasco, Thomas Bylund, Y. A. Gallant, David Sánchez, R. López-Coto, Jorge Cotzomi, Jacques Muller, H. León Vargas, Alison Peisker, Justine Devin, Thomas Murach, P. Morris, Harm Schoorlemmer, Jonathan Mackey, Andrea Albert, Samuel Zouari, Pascal Vincent, M. Zacharias, Stefan Ohm, S. Pita, Tadayuki Takahashi, Gilgamesh Luis-Raya, A. Yusafzai, Andreas Quirrenbach, Samuel Timothy Spencer, Stefano Gabici, Regis Terrier, Victor Doroshenko, L. Nellen, Włodek Kluźniak, R. Noriega-Papaqui, E. Kasai, C. Moore, L. Oakes, J. Bolmont, Michal Ostrowski, J.-P. Lenain, Pooja Surajbali, William H. Lee, L. Olivera-Nieto, E. Moulin, Tomasz Bulik, Rhiannon Turner, Lente Dreyer, O. Martinez, Stefan Klepser, Alessandro Montanari, D. J. van der Walt, Fernando Ureña-Mena, J. P. Harding, César Alvarez, Michael DuVernois, A.M. Taylor, J. C. Arteaga-Velézquez, Connor Duffy, Davit Zargaryan, R. J. White, Stefan Funk, Alicja Wierzcholska, Dmitriy Kostunin, J. Damascene Mbarubucyeye, R. Rauth, Maria Magdalena González, Kristi Engel, A. Galván-Gámez, Christoph Deil, Krzysztof Katarzynski, F. Eichhorn, Mohanraj Senniappan, E. Moreno, Michael Punch, Axel Donath, B. Hona, A. W. Chen, S. Steinmassl, Sami Caroff, Domenico Tiziani, D. Malyshev, Catherine Boisson, M. Panter, Mora Durocher, U. Katz, Pedro Miranda-Romagnoli, C. Arcaro, H. Zhou, Michael Backes, S. Coutiño de León, Ernesto Belmont-Moreno, M. de Bony de Lavergne, R. Brose, Petra Hüntemeyer, C. Levy, Francois Brun, R. J. Tuffs, B. Bi, Andreas Specovius, Joachim Hahn, K. P. Arunbabu, Riaan Steenkamp, Gavin Rowell, P. Reichherzer, James E. M. Watson, M. Bryan, E. de Oña Wilhelmi, Łukasz Stawarz, C. van Rensburg, Pierre Brun, Brenda Dingus, V. Marandon, J. A. Morales-Soto, M. Büchele, H. Prokoph, C. De León, A. Marcowith, V. Baghmanyan, J. Schäfer, Nu. Komin, Tim Holch, Q. Remy, H. M. Schutte, Isak Delberth Davids, A. Fiasson, Jean-Pierre Ernenwein, Hassan Abdalla, S. Hernandez, Jim Hinton, V. Sahakian, E. De la Fuente, F. Werner, Mischa Breuhaus, Luis Villaseñor, Yu Wun Wong, Hambeleleni Ndiyavala, D. Avila Rojas, G. Lamanna, K. S. Caballero-Mora, Roberta Zanin, G. Emery, Halim Ashkar, Fabian Leuschner, Heiko Salzmann, A. S. Seyffert, Kwok Lung Fan, M. Hörbe, T. Tavernier, Nissim Illich Fraija, P. T. O'Brien, Johannes Veh, S. Sailer, Dmitry Khangulyan, Gilles Maurin, S. J. Fegan, A. Djannati-Ataï, D. Jankowsky, J. Dyks, Celine Armand, M. Füßling, R. Marx, Dieter Horns, M. Tluczykont, F. Ait Benkhali, J. F. Glicenstein, M. U. Nisa, Marek Jamrozy, Clemens Hoischen, A. A. Zdziarski, A. Jardin-Blicq, E. O. Angüner, R. Diaz Hernandez, N. Shafi, Natalia Żywucka, M. de Naurois, Andrea Santangelo, K. Malone, Gwenael Giacinti, L. Sun, M.-H. Grondin, D. Garcia, M. Seglar-Arroyo, B. Khélifi, A. J. Smith, T. Capistrán, B. van Soelen, G. Hermann, Anna Barnacka, D. Gottschall, Anne Lemiere, B. Rudak, Markus Böttcher, K. Tollefson, Jhilik Majumdar, Helene Sol, T. Chand, C. Brisbois, Andreas Zmija, Tom Armstrong, Elijah Willox, Carlo Romoli, Alison Mitchell, R. Torres-Escobedo, Atreyee Sinha, Manuel Meyer, I. Martinez-Castellanos, Zorawar Wadiasingh, A. Priyana Noel, V. Barbosa Martins, C. van Eldik, M. Lemoine-Goumard, M. Tsirou, Michael Kreter, Anna Lia Longinotti, F. Schüssler, Dezhi Huang, Jose Andres Garcia-Gonzalez, Werner Hofmann, Monica Barnard, Juan Carlos Diaz-Velez, V. Poireau, Jimmy N.S. Shapopi, K. Nakashima, José Serna-Franco, G. Peron, Garret Cotter, Jacco Vink, A. Carraminana, Umberto Cotti, Jim Davies, M. A. Kastendieck, Thomas Lohse, K. Kosack, Paolo Marchegiani, Konrad Bernlöhr, Heinrich J. Völk, Sabrina Casanova, Catalina Espinoza, M. Renaud, D. Berge, G. Vasileiadis, F. Salesa Greus, I. Jung-Richardt, Kleopas Shiningayamwe, Gilles Fontaine, J. T. Linnemann, Lenka Tomankova, M. Mostafá, G. Fichet de Clairfontaine, R. Konno, Gianluca Giavitto, V. Joshi, B. Peyaud, G. Pühlhofer, J. A. Goodman, H. Odaka, A. Reimer, R. W. Ellsworth, R. W. Springer, M. Curyło, F. Hueyotl-Zahuantitla, E. G. Pérez-Pérez, Y. Pérez Araujo, A. Nayerhoda, Christian Stegmann, Stefan Wagner, Yasunobu Uchiyama, David Kieda, L. Mohrmann, Misao Sasaki, Markus Holler, Felix Jankowsky, Felix Aharonian, D. Glawion, Jesús Martínez-Castro, Segev BenZvi, Constantin Steppa, L. Giunti, D. A. Prokhorov, Ullrich Schwanke, L. Rinchiuso, J. A. Matthews, Ibrahim Torres, Rachel Simoni, A. Carosi, K. Egberts, S. Chandra, Ruben Alfaro, Sabrina Einecke, Iryna Lypova, Daniel Rosa-Gonzalez, Yvonne Becherini, M. Fernández Alonso, L. Dirson, G. Martí-Devesa, C. Trichard, Sylvia Zhu, P. J. Meintjes, J. H. E. Thiersen, Marion Spir-Jacob, Maria Haupt, C. D. Rho, Rafal Moderski, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Gravitation and Astroparticle Physics Amsterdam, High Energy Astrophys. & Astropart. Phys (API, FNWI), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Collaboration, H.E.S.S., and Collaboration, HAWC

Subjects
High-energy astronomy, media_common.quotation_subject, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, IACT, Field of view, 030226 pharmacology & pharmacy, 01 natural sciences, 03 medical and health sciences, 0302 clinical medicine, Observatory, 0103 physical sciences, High Energy Stereoscopic System, 010303 astronomy & astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Cherenkov radiation, media_common, Physics, [PHYS]Physics [physics], Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy, Astronomy and Astrophysics, Galactic plane, Space and Planetary Science, Sky, Astrophysics - Instrumentation and Methods for Astrophysics, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], High energy astrophysics
Abstract

International audience; The High Altitude Water Cherenkov (HAWC) observatory and the High Energy Stereoscopic System (H.E.S.S.) are two leading instruments in the ground-based very-high-energy γ-ray domain. HAWC employs the water Cherenkov detection (WCD) technique, while H.E.S.S. is an array of Imaging Atmospheric Cherenkov Telescopes (IACTs). The two facilities therefore differ in multiple aspects, including their observation strategy, the size of their field of view, and their angular resolution, leading to different analysis approaches. Until now, it has been unclear if the results of observations by both types of instruments are consistent: several of the recently discovered HAWC sources have been followed up by IACTs, resulting in a confirmed detection only in a minority of cases. With this paper, we go further and try to resolve the tensions between previous results by performing a new analysis of the H.E.S.S. Galactic plane survey data, applying an analysis technique comparable between H.E.S.S. and HAWC. Events above 1 TeV are selected for both data sets, the point-spread function of H.E.S.S. is broadened to approach that of HAWC, and a similar background estimation method is used. This is the first detailed comparison of the Galactic plane observed by both instruments. H.E.S.S. can confirm the γ-ray emission of four HAWC sources among seven previously undetected by IACTs, while the three others have measured fluxes below the sensitivity of the H.E.S.S. data set. Remaining differences in the overall γ-ray flux can be explained by the systematic uncertainties. Therefore, we confirm a consistent view of the γ-ray sky between WCD and IACT techniques.

Published
2021

25. Patient-specific SPECT imaging protocols to standardize image noise

Author

Duncan C. Clackdoyle, Jennifer M. Renaud, R. Glenn Wells, and Sarah G. Cuddy-Walsh

Subjects
Photon, business.industry, Iterative reconstruction, 030204 cardiovascular system & hematology, Patient specific, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Noise, 0302 clinical medicine, Spect imaging, Test set, Image noise, Medicine, Radiology, Nuclear Medicine and imaging, Computer vision, Artificial intelligence, Sensitivity (control systems), Cardiology and Cardiovascular Medicine, business
Abstract

In addition to acquired photon counts, image noise depends on the image reconstruction algorithm. This work develops patient-specific activity or acquisition time protocols to standardize the average noise in a reconstructed image for different patients, cameras, and reconstruction algorithms. Image noise was calculated for images from 43 patients acquired on both a conventional and a multiple-pinhole cardiac SPECT camera. Functions were found to relate image noise to radiotracer activity, scan time, and body mass and were validated by normalizing the image noise in a test set of 58 patients. There was a 3.6-fold difference in photon sensitivity between the two cameras but a 16-fold difference in activity-scan time was necessary to match the noise levels. Image noise doubled from 45 to 128 kg for the conventional camera (12.8 minutes) and tripled for the multiple-pinhole camera (5 minutes) for 350 MBq (9.5 mCi) 99mTc-tetrofosmin. It was 16.3% and 6.1% respectively for an average sized patient. A linear scaling of activity with respect to the patient weight normalizes image noise but the scaling factors depend on the choice of camera and image reconstruction parameters. Therefore, equivalent numbers of acquired photon counts are not sufficient to guarantee equivalent image noise.

Published
2019

26. [18F]FDG cardiac PET imaging in a canine model of radiation-induced cardiovascular disease associated with breast cancer radiotherapy

Author

Gerald Wisenberg, O El-Sherif, J. Geoffrey Pickering, Ilma Xhaferllari, Hao Yin, Jane Sykes, John Butler, Ben Wilk, Rebecca Sullivan, Frank S. Prato, Stewart Gaede, Robert A. deKemp, Jerry J. Battista, and Jennifer M. Renaud

Subjects
medicine.diagnostic_test, Physiology, business.industry, medicine.medical_treatment, Radiation dose, Radiation induced, Breast cancer radiotherapy, 030218 nuclear medicine & medical imaging, Radiation therapy, 03 medical and health sciences, 0302 clinical medicine, Cardiac PET, Positron emission tomography, 030220 oncology & carcinogenesis, Physiology (medical), medicine, Cardiology and Cardiovascular Medicine, Nuclear medicine, business, Canine model, Deposition (chemistry)
Abstract

Radiotherapy for the treatment of left-sided breast cancer increases the long-term risk of cardiovascular disease. The purpose of the present study was to noninvasively image the progression of radiation-induced cardiac inflammation in a large animal model using a hybrid PET and MRI system. Five canines were imaged using [18F]fluorodeoxyglucose PET to assess changes in myocardial inflammation. All animals were imaged at baseline, 1 wk, and 1, 3, 6, and 12 mo after focused cardiac external beam irradiation with image guidance. Radiation was delivered in a single fraction. The linear quadratic model was used to convert a typical multifractionated heart dose to a corrected single-fraction biologically equivalent dose. Immunohistochemistry was performed on excised left ventricular tissue samples from all five irradiated canines and one nonirradiated control canine to confirm the presence of inflammation. The mean doses delivered to the entire heart, left ventricle, left anterior descending artery, and left circumflex artery were 1.7 ± 0.2, 2.7 ± 0.2, 5.5 ± 0.9, and 1.1 ± 0.4 Gy, respectively. FDG standard uptake values remained persistently elevated compared with baseline (1.1 ± 0.03 vs. 2.6 ± 0.19, P < 0.05). The presence of myocardial inflammation was confirmed histologically and correlated with myocardial dose. This study suggests a global inflammatory response that is persistent up to 12 mo postirradiation. Inflammation PET imaging should be considered in future clinical studies to monitor the early changes in cardiac function that may play a role in the ultimate development of radiation-induced cardiac toxicity. NEW & NOTEWORTHY Using advanced cardiac PET imaging, we have shown the spatial and quantitative relationship between radiation dose deposition and temporal changes in inflammation. We have shown that the progression of radiation-induced cardiac inflammation is immediate and does not subside for up to 1 yr after radiation. Results are presented in a large animal model that closely resembles the size and vessel architecture of humans. The proposed imaging protocol can be easily replicated for clinical use.

Published
2019

27. Myocardial flow reserve estimation with contemporary CZT-SPECT andsup99m/supTc-tracers lacks precision for routine clinical application

Author

Jennifer M, Renaud, Alexis, Poitrasson-Rivière, Tomoe, Hagio, Jonathan B, Moody, Liliana, Arida-Moody, Edward P, Ficaro, and Venkatesh L, Murthy

Subjects
Fractional Flow Reserve, Myocardial, Tomography, Emission-Computed, Single-Photon, Coronary Circulation, Myocardium, Positron-Emission Tomography, Myocardial Perfusion Imaging, Humans, Coronary Artery Disease
Abstract

PET myocardial flow reserve (MFR) has established diagnostic and prognostic value. Technological advances have now enabled SPECT MFR quantification. We investigated whether SPECT MFR precision is sufficient for clinical categorization of patients.Validation studies vs invasive flow measurements and PET MFR were reviewed to determine global SPECT MFR thresholds. Studies vs PET and a SPECT MFR repeatability study were used to establish imprecision in SPECT MFR measurements as the standard deviation of the difference between SPECT and PET MFR, or test-retest SPECT MFR. Simulations were used to evaluate the impact of SPECT MFR imprecision on confidence of clinically relevant categorization.Based on validation studies, the typical PET MFR categories were used for SPECT MFR classification (lt; 1.5, 1.5-2.0,gt; 2.0). Imprecision vs PET MFR ranged from 0.556 to 0.829, and test-retest imprecision was 0.781-0.878. Simulations showed correct classification of up to only 34% of patients when 1.5 ≤ true MFR ≤ 2.0. Categorization with high confidence (gt; 80%) was only achieved for extreme MFR values (lt; 1.0 orgt; 2.5), with correct classification in only 15% of patients in a typical lab with MFR of 1.8 ± 0.5.Current SPECT-derived estimates of MFR lack precision and require further optimization for clinical risk stratification.背景: PET 心肌血流储备 (Myocardial Flow Reserve, MFR)诊断和预后价值已经明确。SPECT MFR 的量化随着技术的进步也已实现。我们探讨 SPECT MFR 精度能否满足对患者进行临床分类。 方法: 回顾有创血流测量和PET-MFR对比的研究来确定SPECT的整体MFR阈值。PET和SPECT-MFR重复性研究用于确定SPECT-MFR测量的不精确性, 并以此作为SPECT和PET-MFR之间或SPECT-MFR的重测差异的标准差。模拟用来评估SPECT MFR的不精确性对临床相关分类可信度的影响。 结果: 在验证研究中, SPECT-MFR分类采用典型PET-MFR分类 (lt; 1.5, 1.5-2.0,gt; 2.0)。对比PET-MFR, 不精确度的比值范围为0.556∼0.829, 重测不精确度为0.781∼0.878。模拟显示, 当 1.5≤真实 MFR≤2.0时, 正确分类的患者只有 34%。 在MFR值为1.8±0.5的典型实验模拟中, 只有15%的患者进行了正确的分类, 只有极端的MFR值 (lt; 1.0或gt;2.5) 才能实现高置信度分类 (gt;80%)。 结论: 目前SPECT估计得出的MFR缺乏精确性, 用于临床风险分层尚需要进一步优化。.L’évaluation de la réserve du flot myocardique (RFM) en TEP possède une valeur diagnostique et pronostique reconnue. Des avancées technologiques permettent maintenant une quantification de la RFM à l’aide de la SPECT. MéTHODOLOGIE: Des études de validation versus des mesures de flot invasives et de la RFM en TEP ont été analysées afin de déterminer les seuils globaux de la RFM en SPECT. Les études TEP et de répétabilité de la RFM en SPECT ont été utilisées afin d’établir le degré d’imprécision sur les mesures de la RFM en SPECT comme déviation standard de la différence entre la RFM évaluée en SPECT et en TEP, ou évaluation – réévaluation de la RFM en SPECT. Des simulations ont été utilisées afin d’évaluer l’impact de l’imprécision de la RFM en SPECT sur la confiance de catégorisation clinique. RéSULTATS: Basées sur les études de validation, les catégories de RFM en TEP typiques ont été utilisées pour la classification de la RFM en SPECT (lt; 1.5, 1.5–2.0,gt; 2.0). L’imprécision versus RFM en TEP variait de 0.556 à 0.829 et l’imprécision de l’évaluation-réévaluation était de 0.781–0.878. Les simulations ont démontré une classification correcte jusqu’à seulement 34% des patients lorsque la RFM vraie se situait entre 1.5 et 2.0. Une catégorisation avec un haut degré de confiance (gt; 80%) a été effectuée seulement pour les valeurs extrêmes de RFM (lt; 1.0 ougt; 2.5) avec une classification correcte chez uniquement 15% des patients vus dans un laboratoire typique avec une RFM de 1.8 ± 0.5.Les estimations de la RFM à partir des SPECT actuels manquent de précision et nécessitent davantage d’optimisation pour la stratification du risque clinique.la reserva de flujo miocárdico (RFM) por PET tiene un valor diagnóstico y pronóstico bien establecido. Los avances tecnológicos ahora han permitido la cuantificación RFM por SPECT. Investigamos si la precisión de la RFM por SPECT es suficiente para la categorización clínica de pacientes. MéTODOS: se revisaron los estudios de validación versus mediciones invasivas de flujo y RFM por PET para determinar los puntos de cohorte globales de la RFM por SPECT. Estudios versus PET y un estudio de repetibilidad de la RFM por SPECT fueron usados para establecer la imprecisión de las mediciones de RFM por SPECT como la desviación estándar de la diferencia entre la RFM por SPECT y PET, o estudio-repetir estudio de la RFM por SPECT. Se utilizaron simulaciones para evaluar el impacto de la imprecisión en la confianza de la categorización clínicamente relevante por la RFM por SPECT.basado en estudios de validación, las típicas categorías de la RFM por PET se utilizaron para la clasificación de la RFM por SPECT (lt; 1.5, 1.5–2.0,gt; 2.0). La imprecisión frente a la RFM por PET osciló entre 0.556 y 0.829, y la imprecisión de estudio-repetir estudio fue de 0.781–0.878. Las simulaciones mostraron una correcta clasificación de hasta solo el 34% de los pacientes cuando 1.5 ≤ RFM real ≤ 2.0. La categorización con alta confianza (gt; 80%) solo se logró para valores extremos de RFM (lt; 1.0 ogt; 2.5), con clasificación correcta en solo el 15% de los pacientes en un laboratorio típico con RFM de 1.8 ± 0.5.las estimaciones actuales de MFR derivadas de SPECT carecen de precisión y requieren una mayor optimización para la estratificación del riesgo clínico.

Published
2021

29. Effect of iterations and time of flight on normal distributions ofsup82/supRb PET relative perfusion and myocardial blood flow

Author

Alexis, Poitrasson-Rivière, Jonathan B, Moody, Jennifer M, Renaud, Tomoe, Hagio, Liliana, Arida-Moody, Venkatesh L, Murthy, and Edward P, Ficaro

Subjects
Perfusion, Coronary Circulation, Positron-Emission Tomography, Myocardial Perfusion Imaging, Normal Distribution, Humans
Abstract

As clinical use of myocardial blood flow (MBF) increases, dynamic series are becoming part of the typical workflow. The methods and parameters used to reconstruct these series require investigation to ensure accurate quantification.Fifty-nine rest/stress dynamicsup82/supRb PET studies, acquired on a Biograph mCT, from a combination of normal volunteers and low-likelihood patients were reconstructed with and without time of flight (TOF) for varying iterations and processed to obtain relative perfusion and MBF polar maps. Regional values from mean polar maps were fit to a linear mixed-effect model to quantify convergence and select the optimal number of iterations.TOF reconstructions converged faster and yielded more uniform relative perfusion polar maps. However, the stress MBF distribution for TOF reconstructions was more heterogeneous, with a higher-intensity septal wall. This phenomenon requires further investigation, with right ventricle blood pool spillover possibly having an effect. Optimal reconstructions were defined as 5-iteration non-TOF (24-subset) reconstructions and 3-iteration TOF (21-subset) reconstructions.Optimal cardiac reconstructions were identified for non-TOF and TOF reconstructions of dynamic series. TOF reconstruction presents as the more accurate method, given the more uniform relative perfusion distribution.

Published
2021

30. Does quantification of [

Author

Jean Z, Wang, Jason G E, Zelt, Nicole, Kaps, Aaryn, Lavallee, Jennifer M, Renaud, Benjamin, Rotstein, Rob S B, Beanlands, James A, Fallavollita, John M, Canty, and Robert A, deKemp

Subjects
Ephedrine, Sympathetic Nervous System, Myocardial Ischemia, Heart, Stroke Volume, Risk Assessment, Ventricular Function, Left, Kinetics, Death, Sudden, Cardiac, Ammonia, Positron-Emission Tomography, Humans, Prospective Studies, Cardiomyopathies
Abstract

In ischemic cardiomyopathy patients, cardiac sympathetic nervous system dysfunction is a predictor of sudden cardiac arrest (SCA). This study compared abnormal innervation and perfusion measured by [This is a sub-study analysis of the prospective PAREPET trial, which followed ischemic cardiomyopathy patients with reduced left ventricular ejection fraction (LVEF ≤ 35%) for events of SCA. Using n = 174 paired dynamic HED and NHDuring 4.1 years follow-up, there were 27 SCA events. HED defects were larger than NHQuantification of HED distribution volume and NH

Published
2021

31. Revealing x-ray and gamma ray temporal and spectral similarities in the GRB 190829A afterglow

Author

K. Egberts, Davit Zargaryan, Axel Donath, A. W. Chen, G. Pühlhofer, M. de Bony de Lavergne, V. Poireau, P. T. O'Brien, P. A. Evans, Riaan Steenkamp, A. Lemiere, F. Eichhorn, Nu. Komin, J. Schäfer, Włodek Kluźniak, A. S. Seyffert, N. Shafi, Natalia Żywucka, Sebastian Panny, R. J. White, Domenico Tiziani, D. Malyshev, T. Chand, Jhilik Majumdar, V. Baghmanyan, Clemens Hoischen, A. A. Zdziarski, Jacco Vink, Alison Mitchell, Joachim Hahn, M. Füßling, C. van Eldik, J.F. Glicenstein, Lei Sun, P. Reichherzer, Jim Davies, A. Carosi, Zorawar Wadiasingh, Q. Remy, Anna Barnacka, A. Djannati-Ataï, A. Montanari, E. Moulin, M. de Naurois, Alexandre Marcowith, Arnaud Mares, Christoph Deil, Sabrina Casanova, Christo Venter, G. Peron, Garret Cotter, M. Hörbe, Dmitriy Kostunin, E. Ruiz-Velasco, Mohanraj Senniappan, Thomas Bylund, E. O. Angüner, S. Raab, Tadayuki Takahashi, F. Brun, R. J. Tuffs, B. Bi, H. Prokoph, C. van Rensburg, A. Zech, J. Muller, Monica Barnard, B. Peyaud, Kirsty Feijen, R. Rauth, Pierre Brun, Victor Doroshenko, Michael Punch, E. Kasai, Konrad Bernlöhr, M. Curyło, Stefano Gabici, Gianluca Giavitto, Frank M. Rieger, Michael Backes, Stefan Klepser, J.-P. Ernenwein, A. Dmytriiev, Mischa Breuhaus, J. Dyks, G. Emery, L. Olivera-Nieto, Tim Holch, S. Fegan, Samuel Zouari, M.-H. Grondin, L. Mohrmann, Stefan Ohm, I. Jung-Richardt, Markus Böttcher, K. Kosack, A. Reimer, G. Hermann, Marek Jamrozy, Regis Terrier, S. Pita, Markus Holler, Felix Jankowsky, Armelle Jardin-Blicq, E. de Ona Wilhelmi, A.M. Taylor, Carlo Romoli, J. Damascene Mbarubucyeye, Hester Schutte, Dieter Horns, Jonathan Mackey, Tom Armstrong, Helene Sol, Sylvia Zhu, P. J. Meintjes, Hambeleleni Ndiyavala, G. Fontaine, H. Odaka, Felix Aharonian, V. Barbosa Martins, Andreas Specovius, Michal Ostrowski, Johannes Veh, D. J. van der Walt, Yu Wun Wong, L. Oakes, C. Moore, J. Bolmont, D. Jankowsky, M. Seglar-Arroyo, Paolo Marchegiani, Rachel Simoni, R. Marx, S. Steinmassl, D. Glawion, Łukasz Stawarz, Manuel Meyer, Tomasz Bulik, Lente Dreyer, Andreas Quirrenbach, Sabrina Einecke, Iryna Lypova, Constantin Steppa, D. A. Prokhorov, M. Zacharias, Christopher J. Duffy, A. Wierzcholska, M. Tluczykont, Christian Stegmann, Stefan Wagner, Yasunobu Uchiyama, F. Schüssler, Yvonne Becherini, Jimmy N.S. Shapopi, C. Levy, Werner Hofmann, G. Lamanna, M. A. Kastendieck, James E. M. Watson, Ullrich Schwanke, G. Vasileiadis, Isak Delberth Davids, Misao Sasaki, Bruno Khelifi, M. Büchele, M. Lemoine-Goumard, J. Zorn, Elisabetta Bissaldi, Roberta Zanin, F. Ait Benkhali, L. Rinchiuso, M. Scalici, Y. A. Gallant, J. Devin, Jim Hinton, D. Berge, V. Sahakian, F. Werner, Andrea Santangelo, Stefan Funk, S. Sailer, Dmitry Khangulyan, Michael Kreter, Jacek Niemiec, D. A. Sanchez, A. Priyana Noel, C. Arcaro, Fabian Leuschner, J. H. E. Thiersen, M. Panter, U. Katz, K. Nakashima, Olaf Reimer, G. Martí-Devesa, H. Ashkar, Q. Piel, P. Morris, Gavin Rowell, M. Bryan, Kleopas Shiningayamwe, A. Yusafzai, Thomas Murach, G. Maurin, Maria Haupt, Heinrich J. Völk, M. Renaud, R. D. Parsons, Samuel Timothy Spencer, Lenka Tomankova, T. Tam, G. Fichet de Clairfontaine, A. Sinha, J.-P. Lenain, D. Huber, Rafal Moderski, S. Caroff, B. van Soelen, S. Chandra, R. Konno, L. Dirson, M. Tsirou, B. Rudak, V. Joshi, Thomas Lohse, L. Giunti, A. Nayerhoda, Hassan Abdalla, A. Fiasson, M. Spir-Jacob, V. Marandon, K. Katarzyński, P. Vincent, T. Tavernier, K. L. Page, Heiko Salzmann, Celine Armand, Catherine Boisson, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), H.E.S.S., Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Gravitation and Astroparticle Physics Amsterdam, High Energy Astrophys. & Astropart. Phys (API, FNWI), H.E.S.S. Collaboration, and Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2)

Subjects
Photon, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, gamma ray: burst, 01 natural sciences, Luminosity, HESS, 0103 physical sciences, High Energy Stereoscopic System, 010303 astronomy & astrophysics, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, energy: high, Multidisciplinary, X-ray: energy spectrum, 010308 nuclear & particles physics, photon, Gamma ray, trigger, Light curve, redshift, Redshift, Afterglow, collapse, gamma ray: VHE, HESS - Abteilung Hinton, spectral, Astrophysics - High Energy Astrophysical Phenomena, Gamma-ray burst, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], absorption
Abstract

An intrinsic gamma-ray burst afterglow Long gamma-ray bursts (GRBs) are emitted by relativistic jets generated during the collapse of a massive star in a distant galaxy. The GRB itself lasts only a few seconds but is followed by an afterglow that can persist for hours or days. The H.E.S.S. Collaboration observed the afterglow of GRB 190829A, a nearby long GRB. The proximity of this burst allowed it to be detected at tera–electron volt energies that would otherwise be absorbed in the intergalactic medium. By analyzing the spectrum and light curve at x-ray and gamma-ray wavelengths, the authors show that the afterglow cannot be explained by standard models. Science , abe8560, this issue p. 1081

Published
2021

32. H.e.s.s. And magic observations of a sudden cessation of a very-high-energy γ -ray flare in PKS 1510-089 in May 2016

Author

A. Yusafzai, J. van Scherpenberg, M. Büchele, B. Boccardi, S. Caroff, S. J. Fegan, Daniela Dorner, T. Schweizer, Mosè Mariotti, Gaia Vanzo, Tom Armstrong, Nu. Komin, Pratik Majumdar, M. V. Fonseca, Matteo Cerruti, A. Lemiere, F. Eichhorn, J. Devin, C. Trichard, Michael Punch, Stefano Gabici, M. Palatiello, V. A. Acciari, F. Schüssler, Sylvia Zhu, P. J. Meintjes, Werner Hofmann, Samuel Timothy Spencer, Y. Kajiwara, J. Zorn, D. Dominis Prester, S. Bonnefoy, Constantin Steppa, G. Maurin, Adrian Biland, J. M. Paredes, Antonio Stamerra, U. Barres de Almeida, Tadayuki Takahashi, Damir Lelas, Victor Doroshenko, Davide Depaoli, Dmitriy Kostunin, R. Mirzoyan, T. Surić, D. Gottschall, M. Füßling, Moritz Hütten, Lea Heckmann, M. Gaug, J. Herrera, Ullrich Schwanke, C. Arcaro, H. Abdalla, Lorenzo Bellizzi, Thomas P. Krichbaum, Francesco Dazzi, John Hoang, Martin Will, Dominik Baack, L. Maraschi, Elina Lindfors, M. A. Kastendieck, R. Rauth, V. Baghmanyan, D. Ninci, Koji Noda, Michael Backes, S. Raab, Sanae Inoue, Giacomo D'Amico, Manuel Meyer, Q. Remy, L. Olivera-Nieto, Dorota Sobczyńska, Elisa Bernardini, M. Filipovic, Riaan Steenkamp, Davit Zargaryan, Hambeleleni Ndiyavala, Stefan Klepser, G. Vasileiadis, G. Lamanna, S. G. Jorstad, Daniel Mazin, Jacek Niemiec, Kirsty Feijen, Alessandro Montanari, Tim Holch, Seiya Nozaki, Anna Barnacka, M. Hörbe, Giacomo Bonnoli, D. Strom, T. Tavernier, Takeshi Oka, Axel Donath, J. Rico, A. W. Chen, J. Dyks, T. Chand, Jim Hinton, F. Niederwanger, Olaf Reimer, Daniel Kerszberg, Manuel Delfino, Krzysztof Katarzynski, Ivica Puljak, S. Sailer, Dmitry Khangulyan, Christian Fruck, Gavin Rowell, D. A. Sanchez, Maria Haupt, Julian Sitarek, Alan P. Marscher, Stefano Truzzi, Pablo Peñil, E. O. Angüner, Catherine Boisson, S. Ventura, Dieter Horns, M. Bryan, V. Barbosa Martins, L. Sun, Rachel Simoni, Gerard Fontaine, Jacco Vink, P. Reichherzer, Jim Davies, G. Hermann, Regis Terrier, Clemens Hoischen, A. A. Zdziarski, G. Ferrara, Francois Brun, G. Emery, M. de Bony de Lavergne, P. Vincent, Kyoshi Nishijima, Alessandra Lamastra, G. Fichet de Clairfontaine, E. de Oña Wilhelmi, P. Munar-Adrover, Yoshiki Ohtani, Carlo Romoli, Jordi Delgado, Wrijupan Bhattacharyya, L. Di Venere, D. Zarić, Zorawar Wadiasingh, F. Di Pierro, Ž. Bošnjak, Hester Schutte, Isak Delberth Davids, Roberta Zanin, Karl Mannheim, M. Strzys, Łukasz Stawarz, R. J. Tuffs, V. Fallah Ramazani, B. Bi, Marc Ribó, Sabrina Casanova, H. Prokoph, A. Carosi, Stefano Covino, D. J. van der Walt, Thomas Murach, Yating Chai, Saša Mićanović, Jae-Young Kim, V. Vitale, Francesco Longo, R. Konno, Alicia Fattorini, Narek Sahakyan, Y. A. Gallant, R. J. García López, Junko Kushida, Jürgen Besenrieder, Dario Hrupec, P. Da Vela, S. Steinmassl, P. G. Prada Moroni, Jonathan Mackey, Rafal Moderski, Stefan Cikota, Hidetoshi Kubo, Armelle Jardin-Blicq, Monica Barnard, J. Otero-Santos, Mischa Breuhaus, J. Becerra González, Yu. W. Wong, V. Joshi, Samuel Zouari, N. Shafi, Natalia Żywucka, E. Prandini, M. A. Lopez, Gianluca Giavitto, Katsuaki Asano, Mitsunari Takahashi, T. Vuillaume, M. Curyło, P. Morris, K. Egberts, Stefano Ansoldi, M. de Naurois, Pawel Gliwny, L. Pavletić, C. Moore, Alessia Spolon, M. Vazquez Acosta, D. Elsaesser, Tomoki Saito, Giovanni Ceribella, Riccardo Paoletti, Celine Armand, Jhilik Majumdar, Stefan Ohm, G. Busetto, Léa Jouvin, Ana Babić, Frank M. Rieger, A. Dmytriiev, Dorit Glawion, Z. R. Weaver, Włodek Kluźniak, S. Chandra, V. Marandon, A. Djannati-Ataï, E. Moulin, Tomasz Bulik, Alessio Berti, M. Seglar-Arroyo, H. Odaka, Christian Stegmann, Stefan Wagner, C. Perennes, Pierre Brun, Yasunobu Uchiyama, A. Fiasson, U. Colin, David A. Green, Kazuma Ishio, A. Arbet Engels, A. De Angelis, Wlodek Bednarek, Nikola Godinovic, F. Ait Benkhali, Vassil Verguilov, Camilla Maggio, L. Mohrmann, Jean-Pierre Ernenwein, M. Spir-Jacob, M. Karjalainen, Vitaly Neustroev, P. deWilt, M. Scalici, Victoria Moreno, A. Priyana Noel, A. López-Oramas, M. Lemoine-Goumard, N. Torres-Albà, Martin Makariev, C. van Rensburg, Oscar Blanch, S. Pita, Alexander Hahn, V. Sahakian, Yusuke Suda, S. Schwemmer, Thomas Lohse, Misao Sasaki, Daniel Morcuende, Johannes Veh, D. Jankowsky, Michael Kreter, D. Berge, Luca Tosti, R. Marx, F. Werner, V. Poireau, Andrea Santangelo, C. Nigro, Andreas Quirrenbach, Jose Luis Contreras, E. Ruiz-Velasco, Thomas Bylund, M. Tluczykont, V. D'Elia, A. S. Seyffert, Jose Miguel Miranda, Massimo Persic, L. Dirson, Efthalia Traianou, Carlo Vigorito, Sargis Gasparyan, Y. Kobayashi, Jacques Muller, Jeffrey A. Hodgson, Marek Jamrozy, Christoph Deil, I. Jung-Richardt, Joachim Hahn, Mohanraj Senniappan, A. Rugliancich, Marina Manganaro, K. Nakashima, Kleopas Shiningayamwe, Alice Donini, Michelle Tsirou, Yuki Iwamura, G. Maneva, L. A. Antonelli, Juan Cortina, Markus Holler, Michal Ostrowski, Wolfgang Rhode, L. Rinchiuso, Felix Jankowsky, Sebastian Panny, M. I. Martínez, Michael Zacharias, Ferdinando Giordano, Felix Aharonian, Lluis Font, J.-P. Lenain, Merja Tornikoski, B. Machado de Oliveira Fraga, M.-H. Grondin, Lenka Tomankova, Markus Böttcher, Alison Mitchell, Chiara Righi, E. Do Souto Espiñeira, Tomislav Terzić, Alexandre Marcowith, P. Temnikov, Helene Sol, Sabrina Einecke, Iryna Lypova, Toshiaki Inada, Rodolfo Carosi, R. D. Parsons, Yvonne Becherini, Shunsuke Sakurai, L. Giunti, A. Nayerhoda, Arnaud Mares, Chaitanya Priyadarshi, Satoshi Fukami, Konstancja Satalecka, Stefan Funk, Johan Bregeon, Sidika Merve Colak, Alicja Wierzcholska, R. J. White, F. Leone, Michele Doro, D. Huber, Carolina Casadio, Anne Lähteenmäki, Masahiro Teshima, Domenico Tiziani, D. Malyshev, M. Panter, U. Katz, Heinrich J. Völk, G. Martí-Devesa, C. Levy, M. Renaud, J. A. Barrio, Kai Phillip Schmidt, L. Oakes, N. Giglietto, Simone Mender, Paolo Marchegiani, Ashot Chilingarian, Tjark Miener, James E. M. Watson, David Paneque, J. Bolmont, Manuela Mallamaci, Halim Ashkar, A. Sinha, Fabrizio Tavecchio, Kari Nilsson, B. van Soelen, B. Rudak, R. Adam, D. Miceli, M. Mohamed, Saverio Lombardi, E. Molina, P. T. O'Brien, E. Colombo, Lab Saha, Luca Foffano, C. van Eldik, G. Peron, Garret Cotter, D. Hadasch, D. A. Prokhorov, K. Kosack, Konrad Bernlöhr, B. Peyaud, I. Vovk, G. Pühlhofer, A. Reimer, J. F. Glicenstein, Bruno Khelifi, Serena Loporchio, I. Snidaric, Abelardo Moralejo, Andreas Specovius, E. Moretti, Bernd Schleicher, M. Minev, B. De Lotto, Andrés Baquero, A.M. Taylor, J. Damascene Mbarubucyeye, Christo Venter, Ciro Bigongiari, A. Zech, M. Garczarczyk, R. López-Coto, Q. Piel, Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire Univers et Particules de Montpellier (LUPM), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), H.E.S.S., MAGIC, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), German Research Foundation, Istituto Nazionale di Fisica Nucleare, Istituto Nazionale di Astrofisica, Swiss National Science Foundation, Ministerio de Economía y Competitividad (España), Department of Atomic Energy (India), Academy of Finland, University of Tokyo, La Caixa, Croatian Science Foundation, University of Rijeka, Polish National Agency for Academic Exchange, Abdalla, H., Adam, R., Aharonian, F., Ait Benkhali, F., Ang??ner, E. O., Arcaro, C., Armand, C., Armstrong, T., Ashkar, H., Backes, M., Baghmanyan, V., Barbosa Martins, V., Barnacka, A., Barnard, M., Becherini, Y., Berge, D., Bernl??hr, K., Bi, B., B??ttcher, M., Boisson, C., Bolmont, J., Bonnefoy, S., de Bony de Lavergne, M., Bregeon, J., Breuhaus, M., Brun, F., Brun, P., Bryan, M., B??chele, M., Bulik, T., Bylund, T., Caroff, S., Carosi, A., Casanova, S., Chand, T., Chandra, S., Chen, A., Cotter, G., Cury??o, M., Damascene Mbarubucyeye, J., Davids, I. D., Davies, J., Deil, C., Devin, J., Dewilt, P., Dirson, L., Djannati-Ata??, A., Dmytriiev, A., Donath, A., Doroshenko, V., Dyks, J., Egberts, K., Eichhorn, F., Einecke, S., Emery, G., Ernenwein, J. -P., Feijen, K., Fegan, S., Fiasson, A., Fichet de Clairfontaine, G., Filipovic, M., Fontaine, G., Funk, S., F????ling, M., Gabici, S., Gallant, Y. A., Giavitto, G., Giunti, L., Glawion, D., Glicenstein, J. F., Gottschall, D., Grondin, M. -H., Hahn, J., Haupt, M., Hermann, G., Hinton, J. A., Hofmann, W., Hoischen, C., Holch, T. L., Holler, M., H??rbe, M., Horns, D., Huber, D., Jamrozy, M., Jankowsky, D., Jankowsky, F., Jardin-Blicq, A., Joshi, V., Jung-Richardt, I., Kastendieck, M. A., Katarzy??ski, K., Katz, U., Khangulyan, D., Kh??lifi, B., Klepser, S., Klu??niak, W., Komin, Nu., Konno, R., Kosack, K., Kostunin, D., Kreter, M., Lamanna, G., Lemi??re, A., Lemoine-Goumard, M., Lenain, J. -P., Levy, C., Lohse, T., Lypova, I., Mackey, J., Majumdar, J., Malyshev, D., Marandon, V., Marchegiani, P., Marcowith, A., Mares, A., Mart??-Devesa, G., Marx, R., Maurin, G., Meintjes, P. J., Meyer, M., Mitchell, A. M. W., Moderski, R., Mohamed, M., Mohrmann, L., Montanari, A., Moore, C., Morris, P., Moulin, E., Muller, J., Murach, T., Nakashima, K., Nayerhoda, A., de Naurois, M., Ndiyavala, H., Niederwanger, F., Niemiec, J., Oakes, L., O???brien, P., Odaka, H., Ohm, S., Olivera-Nieto, L., de Ona Wilhelmi, E., Ostrowski, M., Panter, M., Panny, S., Parsons, R. D., Peron, G., Peyaud, B., Piel, Q., Pita, S., Poireau, V., Priyana Noel, A., Prokhorov, D. A., Prokoph, H., P??hlhofer, G., Punch, M., Quirrenbach, A., Raab, S., Rauth, R., Reichherzer, P., Reimer, A., Reimer, O., Remy, Q., Renaud, M., Rieger, F., Rinchiuso, L., Romoli, C., Rowell, G., Rudak, B., Ruiz-Velasco, E., Sahakian, V., Sailer, S., Sanchez, D. A., Santangelo, A., Sasaki, M., Scalici, M., Sch??ssler, F., Schutte, H. M., Schwanke, U., Schwemmer, S., Seglar-Arroyo, M., Senniappan, M., Seyffert, A. S., Shafi, N., Shiningayamwe, K., Simoni, R., Sinha, A., Sol, H., Specovius, A., Spencer, S., Spir-Jacob, M., Stawarz, ??., Sun, L., Steenkamp, R., Stegmann, C., Steinmassl, S., Steppa, C., Takahashi, T., Tavernier, T., Taylor, A. M., Terrier, R., Tiziani, D., Tluczykont, M., Tomankova, L., Trichard, C., Tsirou, M., Tuffs, R., Uchiyama, Y., van der Walt, D. J., van Eldik, C., van Rensburg, C., van Soelen, B., Vasileiadis, G., Veh, J., Venter, C., Vincent, P., Vink, J., V??lk, H. J., Vuillaume, T., Wadiasingh, Z., Wagner, S. J., Watson, J., Werner, F., White, R., Wierzcholska, A., Wong, Yu. W., Yusafzai, A., Zacharias, M., Zanin, R., Zargaryan, D., Zdziarski, A. A., Zech, A., Zhu, S. J., Zorn, J., Zouari, S., ywucka, N., Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Asano, K., Baack, D., Babi??, A., Baquero, A., Barres de Almeida, U., Barrio, J. A., Becerra Gonz??lez, J., Bednarek, W., Bellizzi, L., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bo??njak, ??., Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colin, U., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D???amico, G., D???elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espi??eira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Ferrara, G., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Garc??a L??pez, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinovi??, N., Green, D., Hadasch, D., Hahn, A., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., H??tten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jouvin, L., Kajiwara, Y., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., L??pez, M., L??pez-Coto, R., L??pez-Oramas, A., Loporchio, S., Machado de Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Mart??nez, M., Mazin, D., Mender, S., Mi??anovi??, S., Miceli, D., Miener, T., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Munar-Adrover, P., Neustroev, V., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavleti??, L., Pe??il, P., Perennes, C., Persic, M., Prada Moroni, P. G., Prandini, E., Priyadarshi, C., Puljak, I., Rhode, W., Rib??, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Schleicher, B., Schmidt, K., Schweizer, T., Sitarek, J., nidari??, I., Sobczynska, D., Spolon, A., Stamerra, A., Strom, D., Strzys, M., Suda, Y., Suri??, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzi??, T., Teshima, M., Torres-Alb??, N., Tosti, L., Truzzi, S., van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Zari??, D., Jorstad, S. G., Marscher, A. P., Boccardi, B., Casadio, C., Hodgson, J., Kim, J. -Y., Krichbaum, T. P., L??hteenm??ki, A., Tornikoski, M., Traianou, E., Weaver, Z. R., Gravitation and Astroparticle Physics Amsterdam, High Energy Astrophys. & Astropart. Phys (API, FNWI), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Department of Electronics and Nanoengineering, Aalto-yliopisto, and Aalto University

Subjects
non-thermal, quasars: individual: PKS 1510−089, galaxies: active, relativistic processes, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Astrophysics of Galaxies [radiation mechanisms], Photon, individual: PKS 1510−089 [quasars], Astrophysics::High Energy Astrophysical Phenomena, Flux, radiation mechanisms: non-thermal / quasars: individual: PKS 1510−089 / galaxies: active / relativistic processes, radiation mechanisms: non-thermal, quasars: individual: PKS 1510-089, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, law.invention, law, 0103 physical sciences, Galaxies: Active, Quasars: Individual: Pks 1510-089, Radiation mechanisms: Non-thermal, Relativistic processes, individual: PKS 1510-089 [quasars], MAGIC (telescope), 010303 astronomy & astrophysics, Physics, [PHYS]Physics [physics], 010308 nuclear & particles physics, Astronomy and Astrophysics, Quasar, Light curve, non-thermal [radiation mechanisms], relativistic processes [radiation mechanisms], Extragalactic background light, Space and Planetary Science, active [galaxies], ddc:520, Física nuclear, quasars: individual: PKS 1510���089, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Fermi Gamma-ray Space Telescope, Flare
Abstract

The flat spectrum radio quasar (FSRQ) PKS 1510−089 is known for its complex multiwavelength behaviour and it is one of only a few FSRQs detected in very-high-energy (VHE, E > 100 GeV) γ rays. The VHE γ-ray observations with H.E.S.S. and MAGIC in late May and early June 2016 resulted in the detection of an unprecedented flare, which revealed, for the first time, VHE γ-ray intranight variability for this source. While a common variability timescale of 1.5 h has been found, there is a significant deviation near the end of the flare, with a timescale of ∼20 min marking the cessation of the event. The peak flux is nearly two orders of magnitude above the low-level emission. For the first time, a curvature was detected in the VHE γ-ray spectrum of PKS 1510–089, which can be fully explained by the absorption on the part of the extragalactic background light. Optical R-band observations with ATOM revealed a counterpart of the γ-ray flare, even though the detailed flux evolution differs from the VHE γ-ray light curve. Interestingly, a steep flux decrease was observed at the same time as the cessation of the VHE γ-ray flare. In the high-energy (HE, E > 100 MeV) γ-ray band, only a moderate flux increase was observed with Fermi-LAT, while the HE γ-ray spectrum significantly hardens up to a photon index of 1.6. A search for broad-line region (BLR) absorption features in the γ-ray spectrum indicates that the emission region is located outside of the BLR. Radio very-long-baseline interferometry observations reveal a fast-moving knot interacting with a standing jet feature around the time of the flare. As the standing feature is located ∼50 pc from the black hole, the emission region of the flare may have been located at a significant distance from the black hole. If this is indeed a true correlation, the VHE γ rays must have been produced far down in the jet, where turbulent plasma crosses a standing shock., Astronomy & Astrophysics, 648, ISSN:0004-6361, ISSN:1432-0746

Published
2021

33. Broadband Multi-wavelength Properties of M87 during the 2017 Event Horizon Telescope Campaign

Author

Masanori Nakamura, R. Shang, Abelardo Moralejo, A. Rugliancich, Marina Manganaro, Jun Liu, Monika Moscibrodzka, Andreas Specovius, V. Ramakrishnan, S. O'Brien, Michal Ostrowski, Luis C. Ho, Sera Markoff, D. Depaoli, I. Jung-Richardt, Manel Errando, Chiara Righi, S. Panny, Toshiaki Inada, Alexandra J. Tetarenko, Daniela Dorner, Norbert Wex, Nimesh A. Patel, Olivier Hervet, C. Arcaro, Alasdair E. Gent, Yu Wun Wong, Gaia Vanzo, Pierre Brun, Konstancja Satalecka, Stefan Funk, Lorenzo Bellizzi, Michael Lindqvist, Michele Doro, Felix Jankowsky, P. Kaaret, Nicholas R. MacDonald, Lang Cui, P. Temnikov, S. Patel, Sabrina Einecke, Manuel Artero, E. Moretti, Hope Boyce, M. Gaug, Charles F. Gammie, Iryna Lypova, Gisela N. Ortiz-León, Felix Aharonian, Colin J. Lonsdale, Buell T. Jannuzi, Gavin Rowell, M. Bryan, Yvonne Becherini, Aleksandar Popstefanija, M. Pohl, A. Marcowith, Jean-Pierre Ernenwein, H. Alyson Ford, Wystan Benbow, Karen E. Williamson, Daryl Haggard, Hambeleleni Ndiyavala, Tod R. Lauer, Arnaud Mares, Chaitanya Priyadarshi, Michael Punch, Helge Rottmann, J. Zorn, D. Dominis Prester, Bernd Schleicher, M. Minev, Hector Olivares, Ciriaco Goddi, S. Pita, J. Herrera, Alessia Spolon, Léa Jouvin, Na Wang, G. Martí-Devesa, Tomohiko Oka, Kirsty Feijen, E. Do Souto Espiñeira, Ralph Eatough, Johannes Veh, Stefano Gabici, Tomislav Terzić, D. Glawion, Gilles Fontaine, Bradford Benson, C. B. Rulten, Jenni Jormanainen, Jason SooHoo, Michael Titus, Jose Miguel Delgado, Marcos López-Moya, Freek Roelofs, Wlodek Bednarek, M. Lundy, Richard Anantua, Alessandra Lamastra, P. T. Reynolds, Vassil Verguilov, M. Lemoine-Goumard, G. Fichet de Clairfontaine, L. Di Venere, Michael Kreter, Jose Miguel Miranda, Alan L. Roy, Yating Chai, A. López-Oramas, M. Tluczykont, Jacek Niemiec, R. Konno, Tyler Trent, Olaf Reimer, Heino Falcke, Amanpreet Kaur, M. Panter, Narek Sahakyan, Kasper B. Schmidt, A. Carosi, K. Egberts, L. Maraschi, Stefan Cikota, V. Joshi, Koji Noda, Elisa Bernardini, Ye-Fei Yuan, Garrett K. Keating, Fumie Tazaki, Pawel Gliwny, M. Vazquez Acosta, Nicola Giglietto, M. Capasso, Vincent Piétu, Satoshi Fukami, Roman Gold, Elina Lindfors, Satoki Matsushita, A. Lemiere, F. Eichhorn, U. Katz, Yoshinori Yonekura, N. Shafi, Natalia Żywucka, Michael Kramer, M. Palatiello, Daniel Mazin, Samuel Timothy Spencer, Victoria Moreno, Oliver Porth, Julian Sitarek, Kazi L.J. Rygl, Wen Ping Lo, Geoffrey C. Bower, Ilje Cho, S. Fegan, Samuel Zouari, J. M. Paredes, V. Fallah Ramazani, Thomas Murach, Jim Hinton, R. J. White, F. Leone, S. Loporchio, M. de Naurois, Ed Fomalont, Bart Ripperda, Dominique Broguiere, J. Becerra González, Joseph R. Farah, Q. Feng, Andreas Quirrenbach, Taehyun Jung, C. Trichard, Masahiro Teshima, Domenico Tiziani, D. Malyshev, Richard Plambeck, Lynn D. Matthews, Avery E. Broderick, S. Kumar, T. J. Williamson, M. K. Daniel, Sylvia Zhu, P. J. Meintjes, Tjark Miener, Jodi Christiansen, Roger Brissenden, S. Sailer, Dmitry Khangulyan, David Paneque, Thomas P. Krichbaum, Sergey S. Savchenko, Angelo Ricarte, Riaan Steenkamp, T. Chand, J. Dyks, Francesco Dazzi, V. Baghmanyan, Zorawar Wadiasingh, Kazunori Akiyama, Stefan Ohm, C. Levy, Giovanna Ferrara, Makoto Inoue, Jhilik Majumdar, Nobuyuki Sakai, Dieter Horns, Jorge A. Preciado-López, Cornelia Müller, G. Hermann, Regis Terrier, A. J. Chromey, Dominic W. Pesce, Felix M. Pötzl, Mark Gurwell, Alejandro Cruz-Osorio, Ivan Marti-Vidal, Ben Prather, Tom Armstrong, Jongho Park, Matteo Cerruti, Ziri Younsi, Amy Furniss, Chih-Wei Locutus Huang, Lijing Shao, A. Djannati-Ataï, Shoko Koyama, D. Gottschall, P. Vincent, A. Brill, Kenji Toma, Antonios Nathanail, M. Nievas-Rosillo, M. Seglar-Arroyo, C. Delgado Mendez, Mahito Sasada, G. Busetto, Maciek Wielgus, Marcos Santander, Doosoo Yoon, D. A. Sanchez, Hiroki Okino, Christo Venter, Christiaan D. Brinkerink, James Ryan, S. Mićanović, Raquel Fraga-Encinas, Mark G. Rawlings, G. H. Sembroski, G. Principe, Xiang Liu, Karl Friedrich Schuster, Ronald Hesper, L. Sun, Ciro Bigongiari, Ramesh Narayan, M. Strzys, L. Mohrmann, Daniel R. van Rossum, Y. Ohtani, Wu Jiang, Luciano Rezzolla, Nu. Komin, V. A. Acciari, Katherine L. Bouman, Jürgen Besenrieder, Clemens Hoischen, A. A. Zdziarski, Antonio Tutone, Hung Yi Pu, A. Arbet Engels, J.-P. Lenain, A. De Angelis, Tomoya Hirota, R. J. García López, Carlo Romoli, Werner Hofmann, Tuomas Savolainen, Neil M. Nagar, Minfeng Gu, M. Karjalainen, Vitaly Neustroev, A. N. Otte, John F. C. Wardle, Tomoaki Oyama, Jongsoo Kim, Monica Barnard, J. Otero-Santos, R. D. Parsons, Pierre Christian, A. Priyana Noel, A. S. Seyffert, Shami Chatterjee, E. O. Angüner, David A. Green, Ramesh Karuppusamy, Zhiyuan Li, J. Devin, Dominik Elsaesser, F. Giordano, Santiago Ubach, Michael A. Nowak, Y. Kobayashi, F. Di Pierro, Iniyan Natarajan, A. Zech, M. Garczarczyk, Dmitriy Kostunin, Michael Janssen, Giacomo Bonnoli, Mariafelicia De Laurentis, Kuo Liu, G. Emery, Yutaro Kofuji, Antxon Alberdi, Marco Toliman Lucchini, R. A. Ong, Catherine Boisson, Daniel C. M. Palumbo, Stefan Klepser, Stefano Covino, Motoki Kino, Daniel Kerszberg, C. Armand, Maria Haupt, D. Zarić, K. Pfrang, R. López-Coto, M. Zacharias, Jae-Young Kim, Sheperd S. Doeleman, U. Barres de Almeida, Pratik Majumdar, M. V. Fonseca, Mosè Mariotti, G. Lamanna, Alexander Hahn, Sidika Merve Colak, R. J. Tuffs, B. Bi, Juan-Carlos Algaba, L. Oakes, D. Jankowsky, Y. Kajiwara, R. Marx, Bošnjak, John E. Barrett, Kotaro Niinuma, F. D'Ammando, Qingwen Wu, A. Yusafzai, Christian M. Fromm, Chi-kwan Chan, B. De Lotto, M. Kertzman, Manuela Mallamaci, H. Prokoph, Tadayuki Takahashi, Damir Lelas, Victor Doroshenko, E. Kasai, Lea Heckmann, Bong Won Sohn, Francesco Gabriele Saturni, Shiro Ikeda, T. Vuillaume, Laurent Loinard, G. Maurin, M. Füßling, Martin Will, Yi Chen, Gianluca Giavitto, Remo P. J. Tilanus, M. Spir-Jacob, Alessandro Montanari, Thomas Lohse, Tihomir Surić, J. van Scherpenberg, Per Friberg, He Sun, Luca Tosti, Kiyoaki Wajima, E. Ruiz-Velasco, Thomas Bylund, M. Balokovic, Feng Yuan, S. Nozaki, Mischa Breuhaus, Peter Galison, Y. A. Gallant, L. Olivera-Nieto, Dorota Sobczyńska, Maria-Isabel Bernardos, R. Rauth, Izumi Mizuno, Vincent L. Fish, S. G. Jorstad, Tomoki Saito, Giovanni Ceribella, Jacques Muller, J. P. Finley, Stefano Ansoldi, Boris Georgiev, Marcello Giroletti, Arturo I. Gómez-Ruiz, Karl M. Menten, Aristeidis Noutsos, P. deWilt, Junhan Kim, Alejandro Mus Mejías, Q. Remy, Dong-Jin Kim, P. G. Prada Moroni, Robert Wharton, Riccardo Paoletti, R. R. Prado, Zhi-Qiang Shen, S. Paiano, S. Chandra, Andrés Baquero, Anna Barnacka, Lucy Fortson, Wrijupan Bhattacharyya, Marc Ribó, E. de Ona Wilhelmi, Paul T. P. Ho, Yan-Rong Li, Derek Ward-Thompson, M. Scalici, G. Maneva, Constantin Steppa, Dimitrios Psaltis, A.M. Taylor, J. Damascene Mbarubucyeye, Daniel P. Marrone, Karl Mannheim, W. Boland, P. Morris, D. A. Prokhorov, M. Mohamed, Katsuaki Asano, Gernot Maier, Kotaro Moriyama, H. Odaka, M. Büchele, E. Pueschel, Kazuyoshi Nishijima, Christopher J. Duffy, H. M. Schutte, Camilla Maggio, Mark Kettenis, V. D'Elia, Saverio Lombardi, Ramprasad Rao, Ivica Puljak, R. Mirzoyan, V. Sahakian, Guang Yao Zhao, Adrian Biland, F. Werner, Rafal Moderski, Olivier Gentaz, Ullrich Schwanke, James M. Moran, S. Komossa, Yuzhu Cui, A. Jiménez-Rosales, Arash Roshanineshat, S. Ventura, Lindy Blackburn, David J. James, G. Hughes, Hidetoshi Kubo, Mansour Karami, José L. Gómez, P. Reichherzer, Davit Zargaryan, Paul Tiede, Koushik Chatterjee, Chunchong Ni, Roger Deane, Axel Donath, J. Rico, A. W. Chen, A. Fiasson, Jun Yi Koay, T. B. Humensky, Satoko Sawada-Satoh, Isak Delberth Davids, Alan P. Marscher, Alan E. E. Rogers, Rebecca Azulay, Kazuma Ishio, Paul M. Chesler, D. M. Strom, Carlo Vigorito, Marek Jamrozy, G. Pühlhofer, M. de Bony de Lavergne, Roberta Zanin, T. Schweizer, Elisa Prandini, Helene Sol, Rodolfo Carosi, M. Hörbe, T. Tavernier, Mareki Honma, M. Holler, Gordon T. Richards, Armelle Jardin-Blicq, Paolo Marchegiani, Sang-Sung Lee, D. Huber, Ashot Chilingarian, Nikola Godinovic, F. Ait Benkhali, Jason Dexter, Do-Young Byun, Anton Dmytriiev, Massimo Persic, Alicia Fattorini, L. Dirson, Cosimo Nigro, E. Roache, Sargis Gasparyan, S. Schwemmer, Sara Issaoun, Jessica Dempsey, Andrea Santangelo, Włodek Kluźniak, Mel Rose, Huib Jan van Langevelde, D. J. van der Walt, Elisabetta Liuzzo, A. Stamerra, John Hoang, Michelle Tsirou, Wolfgang Rhode, Tomohisa Kawashima, L. A. Antonelli, Carolin Wunderlich, Keiichi Asada, David A. Williams, Joachim Hahn, P. Moriarty, T. M. Crawford, P. Da Vela, L. Rinchiuso, E. Molina, F. Peter Schloerb, Lovro Pavletić, S. Steinmassl, Des Small, Christoph Deil, Stefano Menchiari, Dan Bintley, K. Nakashima, Alice Donini, David H. Hughes, Heinrich J. Völk, Mohanraj Senniappan, K. A. Farrell, M. Renaud, J. A. Barrio, Miriam Lucio Martinez, Rachel Simoni, P. T. O'Brien, E. Colombo, V. Barbosa Martins, M. Orienti, Efthalia Traianou, Lluis Font, B. Machado de Oliveira Fraga, Y. Suda, J. Neilsen, John Conway, Eduardo Ros, Gibwa Musoke, Tarek M. Hassan, J. Bolmont, A. Sinha, Halim Ashkar, M.-H. Grondin, Daniel Nieto, Lab Saha, Fabrizio Tavecchio, Hyunwook Ro, Michael H. Hecht, Markus Böttcher, Antonio Fuentes, Simone Mender, Moritz Hütten, Ue-Li Pen, Yosuke Mizuno, Gopal Narayanan, Lei Huang, H. Abdalla, M. A. Kastendieck, Nicola Marchili, I. Snidaric, S. Sánchez, G. Vasileiadis, Kari Nilsson, Alexander W. Raymond, Greg Lindahl, Gregory Desvignes, Sascha Trippe, Sanae Inoue, Giacomo D'Amico, W. Jin, B. van Soelen, Andrew Chael, Anne Kathrin Baczko, Shunsuke Sakurai, L. Giunti, A. Nayerhoda, Walter Alef, Jamie Holder, Stefano Truzzi, Pablo Peñil, M. J. Lang, Francois Brun, Frank M. Rieger, V. Vitale, George N. Wong, Jirong Mao, S. Caroff, J. Kushida, André Young, Ru-Sen Lu, Daniel Morcuende, Jose Luis Contreras, Kazuhiro Hada, Juan Cortina, C. van Eldik, Pablo Torne, Raymond Blundell, Jarred Gershon Green, C. B. Adams, James M. Cordes, Jonathan Weintroub, Q. Piel, A. Berti, James E. M. Watson, G. Peron, Ken Young, Garret Cotter, Dario Hrupec, Jonathan Mackey, K. Ragan, John E. Carlstrom, Michael Backes, Tim Holch, D. Hadasch, Stawarz, F. Niederwanger, Feryal Özel, Lia Medeiros, A. Weinstein, Mitsunari Takahashi, Manuel Delfino, C. Y. Kuo, Aviad Levis, Francesco Longo, K. Kosack, Konrad Bernlöhr, Jacco Vink, C. Moore, Michael Bremer, Jim Davies, Jadyn Anczarski, Patrick M. Koch, Sabrina Casanova, Ming-Tang Chen, B. Peyaud, Christian Stegmann, Stefan Wagner, C. Perennes, Yasunobu Uchiyama, David Kieda, Chet Ruszczyk, Hiroshi Nagai, M. Curyło, Andrei Lobanov, Ana Babić, E. Moulin, Tomasz Bulik, Britton Jeter, I. Vovk, Martin Makariev, C. van Rensburg, Oscar Blanch, Rocco Lico, Silke Britzen, Misao Sasaki, A. Reimer, V. Poireau, R. Adam, David Ball, Mark Reynolds, D. Miceli, John L. Quinn, Roberto Garcia, J. F. Glicenstein, D. Ribeiro, A. Wierzcholska, Geoffrey B. Crew, Bruno Khelifi, David Sánchez-Arguelles, Ilse van Bemmel, Michael D. Johnson, J. Anton Zensus, Dominik Baack, Manuel Meyer, E. V. Kravchenko, I. Jiménez, Thomas Bronzwaer, Reshmi Mukherjee, D. Berge, C. Giuri, Kleopas Shiningayamwe, Shan Shan Zhao, Yuki Iwamura, A. D. Falcone, Lenka Tomankova, Carsten Kramer, Jan Wagner, Christian Fruck, B. Rudak, Jordy Davelaar, V. Marandon, K. Katarzyński, Roberto Neri, The EHT MWL Science Working Group, Institut de RadioAstronomie Millimétrique (IRAM), Centre National de la Recherche Scientifique (CNRS), Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics (LESIA), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Instituto de RadioAstronomía Milimétrica (IRAM), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Univers et Théories (LUTH (UMR_8102)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire Univers et Particules de Montpellier (LUPM), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Groupe de Physique des Solides (GPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL), Event Horizon Telescope, Fermi-LAT, H.E.S.S., MAGIC, VERITAS, EAVN, High Energy Astrophys. & Astropart. Phys (API, FNWI), API Other Research (FNWI), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Algaba, Jc, Anczarski, J, Asada, K, Balokovic, M, Chandra, S, Cui, Yz, Falcone, Ad, Giroletti, M, Goddi, C, Hada, K, Haggard, D, Jorstad, S, Kaur, A, Kawashima, T, Keating, G, Kim, Jy, Kino, M, Komossa, S, Kravchenko, Ev, Krichbaum, Tp, Lee, S, Lu, R, Lucchini, M, Markoff, S, Neilsen, J, Nowak, Ma, Park, J, Principe, G, Ramakrishnan, V, Reynolds, Mt, Sasada, M, Savchenko, S, Williamson, Ke, Longo, F, Et, Al., University of Michigan, Department of Electronics and Nanoengineering, Aalto-yliopisto, Aalto University, Algaba, J. C., Anczarski, J., Asada, K., Balokovic, M., Chandra, S., Cui, Y. -Z., Falcone, A. D., Giroletti, M., Goddi, C., Hada, K., Haggard, D., Jorstad, S., Kaur, A., Kawashima, T., Keating, G., Kim, J. -Y., Kino, M., Komossa, S., Kravchenko, E. V., Krichbaum, T. P., Lee, S. -S., Lu, R. -S., Lucchini, M., Markoff, S., Neilsen, J., Nowak, M. A., Park, J., Principe, G., Ramakrishnan, V., Reynolds, M. T., Sasada, M., Savchenko, S. S., Williamson, K. E., Akiyama, K., Alberdi, A., Alef, W., Anantua, R., Azulay, R., Baczko, A. -K., Ball, D., Barrett, J., Bintley, D., Benson, B. A., Blackburn, L., Blundell, R., Boland, W., Bouman, K. L., Bower, G. C., Boyce, H., Bremer, M., Brinkerink, C. D., Brissenden, R., Britzen, S., Broderick, A. E., Broguiere, D., Bronzwaer, T., Byun, D. -Y., Carlstrom, J. E., Chael, A., Chan, C. -K., Chatterjee, S., Chatterjee, K., Chen, M. -T., Chen, Y., Chesler, P. M., Cho, I., Christian, P., Conway, J. E., Cordes, J. M., Crawford, T. M., Crew, G. B., Cruz-Osorio, A., Davelaar, J., De Laurentis, M., Deane, R., Dempsey, J., Desvignes, G., Dexter, J., Doeleman, S. S., Eatough, R. P., Falcke, H., Farah, J., Fish, V. L., Fomalont, E., Ford, H. A., Fraga-Encinas, R., Friberg, P., Fromm, C. M., Fuentes, A., Galison, P., Gammie, C. F., Garcia, R., Gentaz, O., Georgiev, B., Gold, R., Gomez, J. L., Gomez-Ruiz, A. I., Gu, M., Gurwell, M., Hecht, M. H., Hesper, R., Ho, L. C., Ho, P., Honma, M., Huang, C. -W. L., Huang, L., Hughes, D. H., Ikeda, S., Inoue, M., Issaoun, S., James, D. J., Jannuzi, B. T., Janssen, M., Jeter, B., Jiang, W., Jimenez-Rosales, A., Johnson, M. D., Jung, T., Karami, M., Karuppusamy, R., Kettenis, M., Kim, D. -J., Kim, J., Koay, J. Y., Kofuji, Y., Koch, P. M., Koyama, S., Kramer, M., Kramer, C., Kuo, C. -Y., Lauer, T. R., Levis, A., Li, Y. -R., Li, Z., Lindqvist, M., Lico, R., Lindahl, G., Liu, J., Liu, K., Liuzzo, E., Lo, W. -P., Lobanov, A. P., Loinard, L., Lonsdale, C., Macdonald, N. R., Mao, J., Marchili, N., Marrone, D. P., Marscher, A. P., Marti-Vidal, I., Matsushita, S., Matthews, L. D., Medeiros, L., Menten, K. M., Mizuno, I., Mizuno, Y., Moran, J. M., Moriyama, K., Moscibrodzka, M., Muller, C., Musoke, G., Mejias, A. M., Nagai, H., Nagar, N. M., Nakamura, M., Narayan, R., Narayanan, G., Natarajan, I., Nathanail, A., Neri, R., Ni, C., Noutsos, A., Okino, H., Olivares, H., Ortiz-Leon, G. N., Oyama, T., Ozel, F., Palumbo, D. C. M., Patel, N., Pen, U. -L., Pesce, D. W., Pietu, V., Plambeck, R., Popstefanija, A., Porth, O., Potzl, F. M., Prather, B., Preciado-Lopez, J. A., Psaltis, D., Pu, H. -Y., Rao, R., Rawlings, M. G., Raymond, A. W., Rezzolla, L., Ricarte, A., Ripperda, B., Roelofs, F., Rogers, A., Ros, E., Rose, M., Roshanineshat, A., Rottmann, H., Roy, A. L., Ruszczyk, C., Rygl, K. L. J., Sanchez, S., Sanchez-Arguelles, D., Savolainen, T., Schloerb, F. P., Schuster, K. -F., Shao, L., Shen, Z., Small, D., Sohn, B. W., Soohoo, J., Sun, H., Tazaki, F., Tetarenko, A. J., Tiede, P., Tilanus, R. P. J., Titus, M., Toma, K., Torne, P., Trent, T., Traianou, E., Trippe, S., Van Bemmel, I., Van Langevelde, H. J., Van Rossum, D. R., Wagner, J., Ward-Thompson, D., Wardle, J., Weintroub, J., Wex, N., Wharton, R., Wielgus, M., Wong, G. N., Wu, Q., Yoon, D., Young, A., Young, K., Younsi, Z., Yuan, F., Yuan, Y. -F., Zensus, J. A., Zhao, G. -Y., Zhao, S. -S., D'Ammando, F., Orienti, M., Abdalla, H., Adam, R., Aharonian, F., Benkhali, F. A., Anguner, E. O., Arcaro, C., Armand, C., Armstrong, T., Ashkar, H., Backes, M., Baghmanyan, V., Barbosa Martins, V., Barnacka, A., Barnard, M., Becherini, Y., Berge, D., Bernlohr, K., Bi, B., Bottcher, M., Boisson, C., Bolmont, J., De Bony De Lavergne, M., Breuhaus, M., Brun, F., Brun, P., Bryan, M., Buchele, M., Bulik, T., Bylund, T., Caroff, S., Carosi, A., Casanova, S., Chand, T., Chen, A., Cotter, G., Curylo, M., Damascene Mbarubucyeye, J., Davids, I. D., Davies, J., Deil, C., Devin, J., Dewilt, P., Dirson, L., Djannati-Atai, A., Dmytriiev, A., Donath, A., Doroshenko, V., Duffy, C., Dyks, J., Egberts, K., Eichhorn, F., Einecke, S., Emery, G., Ernenwein, J. -P., Feijen, K., Fegan, S., Fiasson, A., De Clairfontaine, G. F., Fontaine, G., Funk, S., Fussling, M., Gabici, S., Gallant, Y. A., Giavitto, G., Giunti, L., Glawion, D., Glicenstein, J. F., Gottschall, D., Grondin, M. -H., Hahn, J., Haupt, M., Hermann, G., Hinton, J. A., Hofmann, W., Hoischen, C., Holch, T. L., Holler, M., Horbe, M., Horns, D., Huber, D., Jamrozy, M., Jankowsky, D., Jankowsky, F., Jardin-Blicq, A., Joshi, V., Jung-Richardt, I., Kasai, E., Kastendieck, M. A., Katarzynski, K., Katz, U., Khangulyan, D., Khelifi, B., Klepser, S., Kluzniak, W., Komin, N., Konno, R., Kosack, K., Kostunin, D., Kreter, M., Lamanna, G., Lemiere, A., Lemoine-Goumard, M., Lenain, J. -P., Levy, C., Lohse, T., Lypova, I., Mackey, J., Majumdar, J., Malyshev, D., Marandon, V., Marchegiani, P., Marcowith, A., Mares, A., Marti-Devesa, G., Marx, R., Maurin, G., Meintjes, P. J., Meyer, M., Moderski, R., Mohamed, M., Mohrmann, L., Montanari, A., Moore, C., Morris, P., Moulin, E., Muller, J., Murach, T., Nakashima, K., Nayerhoda, A., De Naurois, M., Ndiyavala, H., Niederwanger, F., Niemiec, J., Oakes, L., O'Brien, P., Odaka, H., Ohm, S., Olivera-Nieto, L., De Ona Wilhelmi, E., Ostrowski, M., Panter, M., Panny, S., Parsons, R. D., Peron, G., Peyaud, B., Piel, Q., Pita, S., Poireau, V., Noel, A. P., Prokhorov, D. A., Prokoph, H., Puhlhofer, G., Punch, M., Quirrenbach, A., Rauth, R., Reichherzer, P., Reimer, A., Reimer, O., Remy, Q., Renaud, M., Rieger, F., Rinchiuso, L., Romoli, C., Rowell, G., Rudak, B., Ruiz-Velasco, E., Sahakian, V., Sailer, S., Sanchez, D. A., Santangelo, A., Sasaki, M., Scalici, M., Schutte, H. M., Schwanke, U., Schwemmer, S., Seglar-Arroyo, M., Senniappan, M., Seyffert, A. S., Shafi, N., Shiningayamwe, K., Simoni, R., Sinha, A., Sol, H., Specovius, A., Spencer, S., Spir-Jacob, M., Stawarz, L., Sun, L., Steenkamp, R., Stegmann, C., Steinmassl, S., Steppa, C., Takahashi, T., Tavernier, T., Taylor, A. M., Terrier, R., Tiziani, D., Tluczykont, M., Tomankova, L., Trichard, C., Tsirou, M., Tuffs, R., Uchiyama, Y., Van Der Walt, D. J., Van Eldik, C., Van Rensburg, C., Van Soelen, B., Vasileiadis, G., Veh, J., Venter, C., Vincent, P., Vink, J., Volk, H. J., Vuillaume, T., Wadiasingh, Z., Wagner, S. J., Watson, J., Werner, F., White, R., Wierzcholska, A., Wong, Y. W., Yusafzai, A., Zacharias, M., Zanin, R., Zargaryan, D., Zdziarski, A. A., Zech, A., Zhu, S. J., Zorn, J., Zouari, S., Zywucka, N., Acciari, V. A., Ansoldi, S., Antonelli, L. A., Engels, A. A., Artero, M., Asano, K., Baack, D., Babic, A., Baquero, A., De Almeida, U. B., Barrio, J. A., Becerra Gonzalez, J., Bednarek, W., Bellizzi, L., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bosnjak, Z., Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Amico, G., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Delgado Mendez, C., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espineira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Ferrara, G., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Garcia Lopez, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinovic, N., Green, J. G., Green, D., Hadasch, D., Hahn, A., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., Hutten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jimenez, I., Jormanainen, J., Jouvin, L., Kajiwara, Y., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., Lopez-Coto, R., Lopez-Moya, M., Lopez-Oramas, A., Loporchio, S., Machado De Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martinez, M., Mazin, D., Menchiari, S., Mender, S., Micanovic, S., Miceli, D., Miener, T., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Neustroev, V., Nigro, C., Nilsson, K., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletic, L., Penil, P., Perennes, C., Persic, M., Moroni, P. G. P., Prandini, E., Priyadarshi, C., Puljak, I., Rhode, W., Ribo, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schleicher, B., Schmidt, K., Schweizer, T., Sitarek, J., Snidaric, I., Sobczynska, D., Spolon, A., Stamerra, A., Strom, D., Strzys, M., Suda, Y., Suric, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzic, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., Van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Wunderlich, C., Zaric, D., Adams, C. B., Benbow, W., Brill, A., Capasso, M., Christiansen, J. L., Chromey, A. J., Daniel, M. K., Errando, M., Farrell, K. A., Feng, Q., Finley, J. P., Fortson, L., Furniss, A., Gent, A., Giuri, C., Hassan, T., Hervet, O., Holder, J., Hughes, G., Humensky, T. B., Jin, W., Kaaret, P., Kertzman, M., Kieda, D., Kumar, S., Lang, M. J., Lundy, M., Maier, G., Moriarty, P., Mukherjee, R., Nieto, D., Nievas-Rosillo, M., O'Brien, S., Ong, R. A., Otte, A. N., Patel, S., Pfrang, K., Pohl, M., Prado, R. R., Pueschel, E., Quinn, J., Ragan, K., Reynolds, P. T., Ribeiro, D., Richards, G. T., Roache, E., Rulten, C., Ryan, J. L., Santander, M., Sembroski, G. H., Shang, R., Weinstein, A., Williams, D. A., Williamson, T. J., Hirota, T., Cui, L., Niinuma, K., Ro, H., Sakai, N., Sawada-Satoh, S., Wajima, K., Wang, N., Liu, X., Yonekura, Y., German Research Foundation, Istituto Nazionale di Fisica Nucleare, Swiss National Science Foundation, Ministerio de Ciencia, Innovación y Universidades (España), Department of Atomic Energy (India), University of Tokyo, Japan Society for the Promotion of Science, Ministry of Education and Scientific Research (Romania), Academy of Finland, La Caixa, Croatian Science Foundation, Generalitat de Catalunya, Polish National Agency for Academic Exchange, University of Rijeka, Department of Energy (US), Smithsonian Institution, Astronomy, and Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2)

Subjects
Accretion, 010504 meteorology & atmospheric sciences, Astronomy, Flux, Astrophysics, 7. Clean energy, 01 natural sciences, Active galactic nuclei, Radio cores, Low-luminosity active galactic nuclei, High energy astrophysics, Astrophysical black holes, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Astrophysics of Galaxies, 010303 astronomy & astrophysics, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, astro-ph.HE, Radio core, Accretion (meteorology), 520 Astronomie und zugeordnete Wissenschaften, Low-luminosity, active galactic nuclei, Astrophysical black hole, astro-ph.CO, Cosmology and Nongalactic Astrophysics (astro-ph.CO), Active galactic nucleus, High-energy astronomy, astro-ph.GA, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, F500, Astrophysics::Cosmology and Extragalactic Astrophysics, High energy astrophysic, 0103 physical sciences, Very-long-baseline interferometry, ddc:530, Astrophysics::Galaxy Astrophysics, 0105 earth and related environmental sciences, Event Horizon Telescope, Supermassive black hole, Astronomy and Astrophysics, 530 Physik, Galaxy, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), ddc:520, HESS - Abteilung Hinton, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract

Full list of authors: EHT MWL Science Working Group; Algaba, J. C.; Anczarski, J.; Asada, K.; Baloković, M.; Chandra, S.; Cui, Y. -Z.; Falcone, A. D.; Giroletti, M.; Goddi, C.; Hada, K.; Haggard, D.; Jorstad, S.; Kaur, A.; Kawashima, T.; Keating, G.; Kim, J. -Y.; Kino, M.; Komossa, S.; Kravchenko, E. V.; Krichbaum, T. P.; Lee, S. -S.; Lu, R. -S.; Lucchini, M.; Markoff, S.; Neilsen, J.; Nowak, M. A.; Park, J.; Principe, G.; Ramakrishnan, V.; Reynolds, M. T.; Sasada, M.; Savchenko, S. S.; Williamson, K. E.; Event Horizon Telescope Collaboration; Akiyama, Kazunori; Alberdi, Antxon; Alef, Walter; Anantua, Richard; Azulay, Rebecca; Baczko, Anne-Kathrin; Ball, David; Barrett, John; Bintley, Dan; Benson, Bradford A.; Blackburn, Lindy; Blundell, Raymond; Boland, Wilfred; Bouman, Katherine L.; Bower, Geoffrey C.; Boyce, Hope; Bremer, Michael; Brinkerink, Christiaan D.; Brissenden, Roger; Britzen, Silke; Broderick, Avery E.; Broguiere, Dominique; Bronzwaer, Thomas; Byun, Do-Young; Carlstrom, John E.; Chael, Andrew; Chan, Chi-Kwan; Chatterjee, Shami; Chatterjee, Koushik; Chen, Ming-Tang; Chen, Yongjun; Chesler, Paul M.; Cho, Ilje; Christian, Pierre; Conway, John E.; Cordes, James M.; Crawford, Thomas M.; Crew, Geoffrey B.; Cruz-Osorio, Alejandro; Davelaar, Jordy; de Laurentis, Mariafelicia; Deane, Roger; Dempsey, Jessica; Desvignes, Gregory; Dexter, Jason; Doeleman, Sheperd S.; Eatough, Ralph P.; Falcke, Heino; Farah, Joseph; Fish, Vincent L.; Fomalont, Ed; Ford, H. Alyson; Fraga-Encinas, Raquel; Friberg, Per; Fromm, Christian M.; Fuentes, Antonio; Galison, Peter; Gammie, Charles F.; García, Roberto; Gentaz, Olivier; Georgiev, Boris; Gold, Roman; Gómez, José L.; Gómez-Ruiz, Arturo I.; Gu, Minfeng; Gurwell, Mark; Hecht, Michael H.; Hesper, Ronald; Ho, Luis C.; Ho, Paul; Honma, Mareki; Huang, Chih-Wei L.; Huang, Lei; Hughes, David H.; Ikeda, Shiro; Inoue, Makoto; Issaoun, Sara; James, David J.; Jannuzi, Buell T.; Janssen, Michael; Jeter, Britton; Jiang, Wu; Jiménez-Rosales, Alejandra; Johnson, Michael D.; Jung, Taehyun; Karami, Mansour; Karuppusamy, Ramesh; Kettenis, Mark; Kim, Dong-Jin; Kim, Jongsoo; Kim, Junhan; Koay, Jun Yi; Kofuji, Yutaro; Koch, Patrick M.; Koyama, Shoko; Kramer, Michael; Kramer, Carsten; Kuo, Cheng-Yu; Lauer, Tod R.; Levis, Aviad; Li, Yan-Rong; Li, Zhiyuan; Lindqvist, Michael; Lico, Rocco; Lindahl, Greg; Liu, Jun; Liu, Kuo; Liuzzo, Elisabetta; Lo, Wen-Ping; Lobanov, Andrei P.; Loinard, Laurent; Lonsdale, Colin; MacDonald, Nicholas R.; Mao, Jirong; Marchili, Nicola; Marrone, Daniel P.; Marscher, Alan P.; Martí-Vidal, Iván; Matsushita, Satoki; Matthews, Lynn D.; Medeiros, Lia; Menten, Karl M.; Mizuno, Izumi; Mizuno, Yosuke; Moran, James M.; Moriyama, Kotaro; Moscibrodzka, Monika; Müller, Cornelia; Musoke, Gibwa; Mejías, Alejandro Mus; Nagai, Hiroshi; Nagar, Neil M.; Nakamura, Masanori; Narayan, Ramesh; Narayanan, Gopal; Natarajan, Iniyan; Nathanail, Antonios; Neri, Roberto; Ni, Chunchong; Noutsos, Aristeidis; Okino, Hiroki; Olivares, Héctor; Ortiz-León, Gisela N.; Oyama, Tomoaki; Özel, Feryal; Palumbo, Daniel C. M.; Patel, Nimesh; Pen, Ue-Li; Pesce, Dominic W.; Piétu, Vincent; Plambeck, Richard; Popstefanija, Aleksandar; Porth, Oliver; Pötzl, Felix M.; Prather, Ben; Preciado-López, Jorge A.; Psaltis, Dimitrios; Pu, Hung-Yi; Rao, Ramprasad; Rawlings, Mark G.; Raymond, Alexander W.; Rezzolla, Luciano; Ricarte, Angelo; Ripperda, Bart; Roelofs, Freek; Rogers, Alan; Ros, Eduardo; Rose, Mel; Roshanineshat, Arash; Rottmann, Helge; Roy, Alan L.; Ruszczyk, Chet; Rygl, Kazi L. J.; Sánchez, Salvador; Sánchez-Arguelles, David; Savolainen, Tuomas; Schloerb, F. Peter; Schuster, Karl-Friedrich; Shao, Lijing; Shen, Zhiqiang; Small, Des; Sohn, Bong Won; Soohoo, Jason; Sun, He; Tazaki, Fumie; Tetarenko, Alexandra J.; Tiede, Paul; Tilanus, Remo P. J.; Titus, Michael; Toma, Kenji; Torne, Pablo; Trent, Tyler; Traianou, Efthalia; Trippe, Sascha; van Bemmel, Ilse; van Langevelde, Huib Jan; van Rossum, Daniel R.; Wagner, Jan; Ward-Thompson, Derek; Wardle, John; Weintroub, Jonathan; Wex, Norbert; Wharton, Robert; Wielgus, Maciek; Wong, George N.; Wu, Qingwen; Yoon, Doosoo; Young, André; Young, Ken; Younsi, Ziri; Yuan, Feng; Yuan, Ye-Fei; Zensus, J. Anton; Zhao, Guang-Yao; Zhao, Shan-Shan; Fermi Large Area Telescope Collaboration; Principe, G.; Giroletti, M.; D'Ammando, F.; Orienti, M.; H. E. S. S. Collaboration; Abdalla, H.; Adam, R.; Aharonian, F.; Benkhali, F. Ait; Angüner, E. O.; Arcaro, C.; Armand, C.; Armstrong, T.; Ashkar, H.; Backes, M.; Baghmanyan, V.; Barbosa Martins, V.; Barnacka, A.; Barnard, M.; Becherini, Y.; Berge, D.; Bernlöhr, K.; Bi, B.; Böttcher, M.; Boisson, C.; Bolmont, J.; de Lavergne, M. De Bony; Breuhaus, M.; Brun, F.; Brun, P.; Bryan, M.; Büchele, M.; Bulik, T.; Bylund, T.; Caroff, S.; Carosi, A.; Casanova, S.; Chand, T.; Chen, A.; Cotter, G.; Curyło, M.; Damascene Mbarubucyeye, J.; Davids, I. D.; Davies, J.; Deil, C.; Devin, J.; Dewilt, P.; Dirson, L.; Djannati-Ataï, A.; Dmytriiev, A.; Donath, A.; Doroshenko, V.; Duffy, C.; Dyks, J.; Egberts, K.; Eichhorn, F.; Einecke, S.; Emery, G.; Ernenwein, J. -P.; Feijen, K.; Fegan, S.; Fiasson, A.; de Clairfontaine, G. Fichet; Fontaine, G.; Funk, S.; Füßling, M.; Gabici, S.; Gallant, Y. A.; Giavitto, G.; Giunti, L.; Glawion, D.; Glicenstein, J. F.; Gottschall, D.; Grondin, M. -H.; Hahn, J.; Haupt, M.; Hermann, G.; Hinton, J. A.; Hofmann, W.; Hoischen, C.; Holch, T. L.; Holler, M.; Hörbe, M.; Horns, D.; Huber, D.; Jamrozy, M.; Jankowsky, D.; Jankowsky, F.; Jardin-Blicq, A.; Joshi, V.; Jung-Richardt, I.; Kasai, E.; Kastendieck, M. A.; Katarzyński, K.; Katz, U.; Khangulyan, D.; Khélifi, B.; Klepser, S.; Kluźniak, W.; Komin, Nu.; Konno, R.; Kosack, K.; Kostunin, D.; Kreter, M.; Lamanna, G.; Lemière, A.; Lemoine-Goumard, M.; Lenain, J. -P.; Levy, C.; Lohse, T.; Lypova, I.; Mackey, J.; Majumdar, J.; Malyshev, D.; Malyshev, D.; Marandon, V.; Marchegiani, P.; Marcowith, A.; Mares, A.; Martí-Devesa, G.; Marx, R.; Maurin, G.; Meintjes, P. J.; Meyer, M.; Moderski, R.; Mohamed, M.; Mohrmann, L.; Montanari, A.; Moore, C.; Morris, P.; Moulin, E.; Muller, J.; Murach, T.; Nakashima, K.; Nayerhoda, A.; de Naurois, M.; Ndiyavala, H.; Niederwanger, F.; Niemiec, J.; Oakes, L.; O'Brien, P.; Odaka, H.; Ohm, S.; Olivera-Nieto, L.; de Ona Wilhelmi, E.; Ostrowski, M.; Panter, M.; Panny, S.; Parsons, R. D.; Peron, G.; Peyaud, B.; Piel, Q.; Pita, S.; Poireau, V.; Noel, A. Priyana; Prokhorov, D. A.; Prokoph, H.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Rauth, R.; Reichherzer, P.; Reimer, A.; Reimer, O.; Remy, Q.; Renaud, M.; Rieger, F.; Rinchiuso, L.; Romoli, C.; Rowell, G.; Rudak, B.; Ruiz-Velasco, E.; Sahakian, V.; Sailer, S.; Sanchez, D. A.; Santangelo, A.; Sasaki, M.; Scalici, M.; Schutte, H. M.; Schwanke, U.; Schwemmer, S.; Seglar-Arroyo, M.; Senniappan, M.; Seyffert, A. S.; Shafi, N.; Shiningayamwe, K.; Simoni, R.; Sinha, A.; Sol, H.; Specovius, A.; Spencer, S.; Spir-Jacob, M.; Stawarz, Ł.; Sun, L.; Steenkamp, R.; Stegmann, C.; Steinmassl, S.; Steppa, C.; Takahashi, T.; Tavernier, T.; Taylor, A. M.; Terrier, R.; Tiziani, D.; Tluczykont, M.; Tomankova, L.; Trichard, C.; Tsirou, M.; Tuffs, R.; Uchiyama, Y.; van der Walt, D. J.; van Eldik, C.; van Rensburg, C.; van Soelen, B.; Vasileiadis, G.; Veh, J.; Venter, C.; Vincent, P.; Vink, J.; Völk, H. J.; Vuillaume, T.; Wadiasingh, Z.; Wagner, S. J.; Watson, J.; Werner, F.; White, R.; Wierzcholska, A.; Wong, Yu Wun; Yusafzai, A.; Zacharias, M.; Zanin, R.; Zargaryan, D.; Zdziarski, A. A.; Zech, A.; Zhu, S. J.; Zorn, J.; Zouari, S.; Żywucka, N.; MAGIC Collaboration; Acciari, V. A.; Ansoldi, S.; Antonelli, L. A.; Engels, A. Arbet; Artero, M.; Asano, K.; Baack, D.; Babić, A.; Baquero, A.; de Almeida, U. Barres; Barrio, J. A.; Becerra González, J.; Bednarek, W.; Bellizzi, L.; Bernardini, E.; Bernardos, M.; Berti, A.; Besenrieder, J.; Bhattacharyya, W.; Bigongiari, C.; Biland, A.; Blanch, O.; Bonnoli, G.; Bošnjak, Ž.; Busetto, G.; Carosi, R.; Ceribella, G.; Cerruti, M.; Chai, Y.; Chilingarian, A.; Cikota, S.; Colak, S. M.; Colombo, E.; Contreras, J. L.; Cortina, J.; Covino, S.; D'Amico, G.; D'Elia, V.; da Vela, P.; Dazzi, F.; de Angelis, A.; de Lotto, B.; Delfino, M.; Delgado, J.; Delgado Mendez, C.; Depaoli, D.; di Pierro, F.; di Venere, L.; Do Souto Espiñeira, E.; Dominis Prester, D.; Donini, A.; Dorner, D.; Doro, M.; Elsaesser, D.; Ramazani, V. Fallah; Fattorini, A.; Ferrara, G.; Fonseca, M. V.; Font, L.; Fruck, C.; Fukami, S.; García López, R. J.; Garczarczyk, M.; Gasparyan, S.; Gaug, M.; Giglietto, N.; Giordano, F.; Gliwny, P.; Godinović, N.; Green, J. G.; Green, D.; Hadasch, D.; Hahn, A.; Heckmann, L.; Herrera, J.; Hoang, J.; Hrupec, D.; Hütten, M.; Inada, T.; Inoue, S.; Ishio, K.; Iwamura, Y.; Jiménez, I.; Jormanainen, J.; Jouvin, L.; Kajiwara, Y.; Karjalainen, M.; Kerszberg, D.; Kobayashi, Y.; Kubo, H.; Kushida, J.; Lamastra, A.; Lelas, D.; Leone, F.; Lindfors, E.; Lombardi, S.; Longo, F.; López-Coto, R.; López-Moya, M.; López-Oramas, A.; Loporchio, S.; Machado de Oliveira Fraga, B.; Maggio, C.; Majumdar, P.; Makariev, M.; Mallamaci, M.; Maneva, G.; Manganaro, M.; Mannheim, K.; Maraschi, L.; Mariotti, M.; Martínez, M.; Mazin, D.; Menchiari, S.; Mender, S.; Mićanović, S.; Miceli, D.; Miener, T.; Minev, M.; Miranda, J. M.; Mirzoyan, R.; Molina, E.; Moralejo, A.; Morcuende, D.; Moreno, V.; Moretti, E.; Neustroev, V.; Nigro, C.; Nilsson, K.; Nishijima, K.; Noda, K.; Nozaki, S.; Ohtani, Y.; Oka, T.; Otero-Santos, J.; Paiano, S.; Palatiello, M.; Paneque, D.; Paoletti, R.; Paredes, J. M.; Pavletić, L.; Peñil, P.; Perennes, C.; Persic, M.; Moroni, P. G. Prada; Prandini, E.; Priyadarshi, C.; Puljak, I.; Rhode, W.; Ribó, M.; Rico, J.; Righi, C.; Rugliancich, A.; Saha, L.; Sahakyan, N.; Saito, T.; Sakurai, S.; Satalecka, K.; Saturni, F. G.; Schleicher, B.; Schmidt, K.; Schweizer, T.; Sitarek, J.; Šnidarić, I.; Sobczynska, D.; Spolon, A.; Stamerra, A.; Strom, D.; Strzys, M.; Suda, Y.; Surić, T.; Takahashi, M.; Tavecchio, F.; Temnikov, P.; Terzić, T.; Teshima, M.; Tosti, L.; Truzzi, S.; Tutone, A.; Ubach, S.; van Scherpenberg, J.; Vanzo, G.; Vazquez Acosta, M.; Ventura, S.; Verguilov, V.; Vigorito, C. F.; Vitale, V.; Vovk, I.; Will, M.; Wunderlich, C.; Zarić, D.; VERITAS Collaboration; Adams, C. B.; Benbow, W.; Brill, A.; Capasso, M.; Christiansen, J. L.; Chromey, A. J.; Daniel, M. K.; Errando, M.; Farrell, K. A.; Feng, Q.; Finley, J. P.; Fortson, L.; Furniss, A.; Gent, A.; Giuri, C.; Hassan, T.; Hervet, O.; Holder, J.; Hughes, G.; Humensky, T. B.; Jin, W.; Kaaret, P.; Kertzman, M.; Kieda, D.; Kumar, S.; Lang, M. J.; Lundy, M.; Maier, G.; Moriarty, P.; Mukherjee, R.; Nieto, D.; Nievas-Rosillo, M.; O'Brien, S.; Ong, R. A.; Otte, A. N.; Patel, S.; Pfrang, K.; Pohl, M.; Prado, R. R.; Pueschel, E.; Quinn, J.; Ragan, K.; Reynolds, P. T.; Ribeiro, D.; Richards, G. T.; Roache, E.; Rulten, C.; Ryan, J. L.; Santander, M.; Sembroski, G. H.; Shang, R.; Weinstein, A.; Williams, D. A.; Williamson, T. J.; Eavn Collaboration; Hirota, Tomoya; Cui, Lang; Niinuma, Kotaro; Ro, Hyunwook; Sakai, Nobuyuki; Sawada-Satoh, Satoko; Wajima, Kiyoaki; Wang, Na; Liu, Xiang; Yonekura, Yoshinori, In 2017, the Event Horizon Telescope (EHT) Collaboration succeeded in capturing the first direct image of the center of the M87 galaxy. The asymmetric ring morphology and size are consistent with theoretical expectations for a weakly accreting supermassive black hole of mass ∼6.5 × 109 M o˙. The EHTC also partnered with several international facilities in space and on the ground, to arrange an extensive, quasi-simultaneous multi-wavelength campaign. This Letter presents the results and analysis of this campaign, as well as the multi-wavelength data as a legacy data repository. We captured M87 in a historically low state, and the core flux dominates over HST-1 at high energies, making it possible to combine core flux constraints with the more spatially precise very long baseline interferometry data. We present the most complete simultaneous multi-wavelength spectrum of the active nucleus to date, and discuss the complexity and caveats of combining data from different spatial scales into one broadband spectrum. We apply two heuristic, isotropic leptonic single-zone models to provide insight into the basic source properties, but conclude that a structured jet is necessary to explain M87's spectrum. We can exclude that the simultaneous γ-ray emission is produced via inverse Compton emission in the same region producing the EHT mm-band emission, and further conclude that the γ-rays can only be produced in the inner jets (inward of HST-1) if there are strongly particle-dominated regions. Direct synchrotron emission from accelerated protons and secondaries cannot yet be excluded., The financial support of the German BMBF, MPG and HGF; the Italian INFN and INAF; the Swiss National Fund SNF; the ERDF under the Spanish Ministerio de Ciencia e Innovacion (MICINN) (FPA2017-87859-P, FPA2017-85668-P, FPA2017- 82729-C6-5-R, FPA2017-90566-REDC, PID2019-104114RBC31, PID2019-104114RB-C32, PID2019-105510GB-C31,PID 2019-107847RB-C41, PID2019-107847RB-C42, PID2019- 107988GB-C22); the Indian Department of Atomic Energy; the Japanese ICRR, the University of Tokyo, JSPS, and MEXT; the Bulgarian Ministry of Education and Science, National RI Roadmap Project DO1-268/16.12.2019 and the Academy of Finland grant No. 320045 is gratefully acknowledged. This work was also supported by the Spanish Centro de Excelencia “Severo Ochoa” SEV-2016-0588 and CEX2019- 000920-S, and “Maria de Maeztu” CEX2019-000918-M, the Unidad de Excelencia “Maria de Maeztu” MDM-2015-0509- 18-2 and the “la Caixa” Foundation (fellowship LCF/BQ/ PI18/11630012) and by the CERCA program of the Generalitat de Catalunya; by the Croatian Science Foundation (HrZZ) Project IP-2016-06-9782 and the University of Rijeka Project 13.12.1.3.02; by the DFG Collaborative Research Centers SFB823/C4 and SFB876/C3; the Polish National Research Centre grant UMO-2016/22/M/ST9/00382; and by the Brazilian MCTIC, CNPq, and FAPERJ. This research is supported by grants from the U.S. Department of Energy Office of Science, the U.S. National Science Foundation and the Smithsonian Institution, by NSERC in Canada, and by the Helmholtz Association in Germany. This research used resources provided by the Open Science Grid, which is supported by the National Science Foundation and the U.S. Department of Energy’s Office of Science, and resources of the National Energy Research Scientific Computing Center (NERSC), a U.S. Department of Energy Office of Science User Facility operated under Contract No. DE-AC02-05CH11231. We acknowledge the excellent work of the technical support staff at the Fred Lawrence Whipple Observatory and at the collaborating institutions in the construction and operation of the instrument.

Published
2021

34. Progressive facial deformity

Author

Caroline Huart, M. Renaud, and V. Hox

Subjects
Orthodontics, Facial deformity, Otorhinolaryngology, business.industry, Medicine, Surgery, business
Published
2020

37. Une infection par le SARS-Cov-2 peut en cacher une autre

Author

A. Leon, M. Renaud, Christian Debry, Service d'oto-rhino-laryngologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)

Subjects
03 medical and health sciences, 2019-20 coronavirus outbreak, [SPI]Engineering Sciences [physics], 0302 clinical medicine, Coronavirus disease 2019 (COVID-19), Otorhinolaryngology, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Surgery, 030204 cardiovascular system & hematology, Biology, Virology, 030217 neurology & neurosurgery, Article
Published
2020

38. SARS-CoV-2 infection may mask another infection

Author

M. Renaud, A. Leon, and Christian Debry

Subjects
Male, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Pneumonia, Viral, Meningoencephalitis, COVID-19, medicine.disease, Virology, Magnetic Resonance Imaging, Article, Pneumonia, Young Adult, Otorhinolaryngology, Pandemic, medicine, Humans, Surgery, business, Coronavirus Infections, Pandemics
Published
2020
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39. Letter to the editor: Lassen et al. 3D PET/CT

Author

Jennifer M, Renaud, Jonathan B, Moody, and Edward P, Ficaro

Subjects
Coronary Circulation, Positron Emission Tomography Computed Tomography, Positron-Emission Tomography, Myocardial Perfusion Imaging, Humans, Rubidium Radioisotopes
Published
2020

40. Very high energy γ-ray emission from two blazars of unknown redshift and upper limits on their distance

Author

Johan Bregeon, J. Devin, D. Gottschall, Zorawar Wadiasingh, Tadayuki Takahashi, R. J. White, Łukasz Stawarz, V. Barbosa Martins, H.M. Schutte, Maria Haupt, Thomas Lohse, Victor Doroshenko, Domenico Tiziani, M. Lemoine-Goumard, C. Arcaro, Michal Ostrowski, J.-P. Lenain, M. Panter, U. Katz, Michael Kreter, Jim Hinton, A. Lemiere, F. Eichhorn, M. de Naurois, R. Adam, Stefan Ohm, James Davies, Stefan Funk, Alicja Wierzcholska, Michael Punch, S. Sailer, Dmitry Khangulyan, D. A. Sanchez, H. Abdalla, M. Zacharias, M. A. Kastendieck, Stefano Gabici, T. Vuillaume, Rafal Moderski, R. J. Tuffs, N. Shafi, Natalia Żywucka, A. Fiasson, Samuel Timothy Spencer, M. Spir-Jacob, M. Seglar-Arroyo, Alexandre Marcowith, A. Santangelo, V. Baghmanyan, Nu. Komin, T. Chand, Jhilik Majumdar, J. Dyks, V. Joshi, P. deWilt, F. Ait Benkhali, L. Oakes, J. Bolmont, Mischa Breuhaus, Heike Prokoph, E. O. Angüner, G. Lamanna, Anton Dmytriiev, Davit Zargaryan, Ruizhi Yang, Q. Piel, Dmitriy Kostunin, Krzysztof Katarzynski, Catherine Boisson, Axel Donath, A. W. Chen, S. Caroff, V. Sahakian, F. Werner, G. Pühlhofer, Arnaud Mares, D. Jankowsky, R. Marx, M. Füßling, S. Schwemmer, Q. Remy, R. Rauth, Dieter Horns, G. Maurin, Y. A. Gallant, Marek Jamrozy, Clemens Hoischen, A. A. Zdziarski, A.S. Seyffert, R. Konno, M. Barnard, S. Nakashima, Anna Barnacka, Gavin Rowell, M. Mohamed, Riaan Steenkamp, M. Bryan, Helene Sol, A. Carosi, M. Hörbe, Sylvia Zhu, P. J. Meintjes, Michelle Tsirou, Christian Stegmann, Stefan Wagner, E. de Oña Wilhelmi, D. Malyshev, S. Raab, Yasunobu Uchiyama, J. Zorn, L. Rinchiuso, Isak Delberth Davids, Kirsty Feijen, Frank M. Rieger, Pierre Brun, R. D. Parsons, T. Tavernier, Jean-Pierre Ernenwein, I. Jung-Richardt, Jason John Watson, Roberta Zanin, L. Mohrmann, V. Poireau, Gianluca Giavitto, C. van Rensburg, S. Pita, Johannes Veh, K. Bernlöhr, H. Yoneda, Paolo Marchegiani, M. Tluczykont, D. J. van der Walt, A. Djannati-Ataï, Francois Brun, P. Vincent, Markus Holler, Misao Sasaki, Felix Jankowsky, Jacek Niemiec, V. Marandon, C. Trichard, H. Odaka, Felix Aharonian, Olaf Reimer, S. Bonnefoy, Constantin Steppa, Garret Cotter, Celine Armand, Michael Backes, E. Ruiz-Velasco, Thomas Bylund, D. Huber, M.-H. Grondin, Tim Holch, E. Leser, Thomas Murach, Joachim Hahn, J. Muller, G. Hermann, Regis Terrier, D. A. Prokhorov, K. Kosack, C. Levy, Ullrich Schwanke, Naomi Tsuji, Carlo Romoli, Angel Noel, Jonathan Mackey, D. Berge, Gerard Fontaine, B. Peyaud, Iryna Lypova, S. Chandra, L. Giunti, M. Katsuragawa, Yvonne Becherini, C. Moore, Dorit Glawion, K. Egberts, E. Moulin, A. Reimer, Tomasz Bulik, Halim Ashkar, Andreas Quirrenbach, M. Böttcher, Paul J. Morris, Kleopas Shiningayamwe, P. T. O'Brien, Lenka Tomankova, C. van Eldik, L. Dirson, J. F. Glicenstein, Tom Armstrong, Matteo Cerruti, H. Ndiyavala, B. van Soelen, B. Rudak, F. Schüssler, Werner Hofmann, M. Büchele, S. J. Fegan, F. Niederwanger, Bruno Khelifi, Jacco Vink, Sabrina Casanova, M. Curyło, Rachel Simoni, Masanori Arakawa, M. Scalici, G. Martí-Devesa, H. Iwasaki, G. Vasileiadis, Włodek Kluźniak, Christoph Deil, Mohanraj Senniappan, G. Emery, S. Saito, Armelle Jardin-Blicq, K. Nakashima, Heinrich J. Völk, M. Renaud, A. Sinha, Christo Venter, A. Zech, A.M. Taylor, Andreas Specovius, Stefan Klepser, Faculty of Science, High Energy Astrophys. & Astropart. Phys (API, FNWI), Gravitation and Astroparticle Physics Amsterdam, Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Galaxies, Etoiles, Physique, Instrumentation (GEPI), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), H.E.S.S., German Research Foundation, Alexander von Humboldt Foundation, Centre National de la Recherche Scientifique (France), Japan Society for the Promotion of Science, Science and Technology Facilities Council (UK), Fundación 'la Caixa', National Aeronautics and Space Administration (US), H.E.S.S. Collaboration, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), 26598973 - Abdalla, Hassan, 30588766 - Arcaro, Cornelia, 28644743 - Backes, Michael, 20574266 - Barnard, Monica, 24420530 - Böttcher, Markus, 30366755 - Chand, Tej B., 31125417 - Chandra, Sunil, 33379009 - Kreter, Michael, 26403366 - Ndiyavala, Hambeleleni, 22799133 - Schutte, Hester M., 20126999 - Seyffert, Albertus Stefanus, 10060499 - Van der Walt, Diederick Johannes, 21106266 - Van Rensburg, Carlo, 12006653 - Venter, Christo, 26594080 - Wadiasingh, Zorawar, 29092086 - Zacharias, Michael, and 34208968 - Zywucka-Hejzner, Natalia

Subjects
individual [BL Lacertae objects], Swift Gamma-Ray Burst Mission, VHE [gamma ray], satellite, Resolved and unresolved sources as a function of wavelength, Astrophysics, 01 natural sciences, GLAST, blazar, high-redshift [Galaxies], galaxies: high-redshift, 5/3, HESS, 0103 physical sciences, Atom, High Energy Stereoscopic System, Spectroscopy, Blazar, 010303 astronomy & astrophysics, BL Lacertae objects: individual, Astroparticle physics, Physics, general [Gamma-rays], energy: high, 010308 nuclear & particles physics, Astronomy and Astrophysics, gamma-rays: general, redshift, Redshift, gamma ray: VHE, 13. Climate action, Space and Planetary Science, ddc:520, high [energy], HESS - Abteilung Hinton, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Fermi Gamma-ray Space Telescope
Abstract

H.E.S.S. Collaboration: et al., We report on the detection of very high energy (VHE; E > 100 GeV) γ-ray emission from the BL Lac objects KUV 00311−1938 and PKS 1440−389 with the High Energy Stereoscopic System (H.E.S.S.). H.E.S.S. observations were accompanied or preceded by multiwavelength observations with Fermi/LAT, XRT and UVOT onboard the Swift satellite, and ATOM. Based on an extrapolation of the Fermi/LAT spectrum towards the VHE γ-ray regime, we deduce a 95 per cent confidence level upper limit on the unknown redshift of KUV 00311−1938 of z < 0.98 and of PKS 1440−389 of z < 0.53. When combined with previous spectroscopy results, the redshift of KUV 00311−1938 is constrained to 0.51 ≤ z < 0.98 and of PKS 1440−389 to 0.14 ⪅ z < 0.53., The support of the Namibian authorities and of the University of Namibia in facilitating the construction and operation of H.E.S.S. is gratefully acknowledged, as is the support by the German Ministry for Education and Research (BMBF), the Max Planck Society, the German Research Foundation (DFG), the Helmholtz Association, the Alexander von Humboldt Foundation, the French Ministry of Higher Education, Research and Innovation, the Centre National de la Recherche Scientifique (CNRS/IN2P3 and CNRS/INSU), the Commissariat a l'Energie Atomique et aux Energies Alternatives (CEA), the U.K. Science and Technology Facilities Council (STFC), the Knut and Alice Wallenberg Foundation, the National Science Centre, Poland grant no. 2016/22/M/ST9/00382, the South African Department of Science and Technology and National Research Foundation, the University of Namibia, the National Commission on Research, Science and Technology of Namibia (NCRST), the Austrian Federal Ministry of Education, Science and Research and the Austrian Science Fund (FWF), the Australian Research Council (ARC), the Japan Society for the Promotion of Science, and the University of Amsterdam. We appreciate the excellent work of the technical support staff in Berlin, Zeuthen, Heidelberg, Palaiseau, Paris, Saclay, Tubingen, and in Namibia in the construction and operation of the equipment. This work benefited from services provided by the H.E.S.S. Virtual Organisation, supported by the national resource providers of the EGI Federation. The H.E.S.S. and Fermi/LAT analysis computations were performed on resources provided by the Swedish National Infrastructure for Computing (SNIC) at Lunarc. Tomas Bylund and Yvonne Becherini wish to acknowledge the support of the Data Intensive Sciences and Applications (DISA) centre at Linnaeus University. Matteo Cerruti has received financial support through the Postdoctoral Junior Leader Fellowship Programme from “la Caixa” Foundation (LCF/BQ/PI18/11630012). This research made use of the NASA/IPAC Extragalactic Database (NED) and of the SIMBAD Astronomical Database, of data products from the Wide-field Infrared Survey Explorer, which is a joint project of the University of California, Los Angeles, and the Jet Propulsion Laboratory/California Institute of Technology, funded by the National Aeronautics and Space Administration. We acknowledge the use of public data from the Swift data archive. This research made use of Gammapy, a community- developed core Python package for gamma-ray astronomy (Deil et al. 2017). This research has made use of data and software provided by the Fermi Science Support Center, managed by the HEASARC at the Goddard Space Flight Center. Part of this work is based on archival data, software or online services provided by the Space Science Data Center - ASI. This research has made use of the VizieR catalogue access tool, CDS, Strasbourg, France (doi:10.26093/cds/vizier). The original description of the VizieR service was published in A&AS 143, 23. This research has made use of the NASA/IPAC Infrared Science Archive, which is funded by the National Aeronautics and Space Administration and operated by the California Institute of Technology.

Published
2020

41. Prospects on high-energy source searches based on pattern recognition: Object detection in the H.E.S.S. Galactic Plane Survey and catalogue cross-matches

Author

Q. Remy, M. Renaud, Y. A. Gallant, Laboratoire Univers et Particules de Montpellier (LUPM), and Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
FOS: Physical sciences, Gamma rays: Sources, 01 natural sciences, Edge detection, Hough transform, law.invention, Coincident, law, Methods: data analysis, HESS, 0103 physical sciences, supernova, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Instrumentation and Methods for Astrophysics (astro-ph.IM), 010303 astronomy & astrophysics, circle, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, 010308 nuclear & particles physics, business.industry, track data analysis, Astronomy and Astrophysics, Pattern recognition, Galactic plane, Object (computer science), Galaxy, Object detection, gamma ray: VHE, TeV: supernova remnants, Pattern recognition (psychology), Artificial intelligence, galaxy, business, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

International audience; The H.E.S.S. Galactic Plane Survey [HGPS, 1] represents one of the most sensitive surveys of the Galactic Plane at very high energies (VHE, 0.1

Published
2020

42. Time-dependent high-energy gamma-ray signal from accelerated particles in core-collapse supernovae: the case of SN 1993J

Author

P. Cristofari, V. Tatischeff, Vikram V. Dwarkadas, Alexandre Marcowith, M. Renaud, Laboratoire Univers et Particules de Montpellier (LUPM), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), and Starita, Sabine

Subjects
Cherenkov Telescope Array, accelerator, Astrophysics::High Energy Astrophysical Phenomena, Population, FOS: Physical sciences, Cosmic ray, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, 01 natural sciences, particle: acceleration, supernovae: general, cosmic rays, photon: emission, supernova, effect: geometrical, 0103 physical sciences, gamma ray: flux, education, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, two-photon, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, education.field_of_study, 010308 nuclear & particles physics, Gamma ray, Astronomy and Astrophysics, shock waves, suppression, gamma-rays: general, Particle acceleration, Supernova, collapse, pair production, gamma ray: emission, Pair production, annihilation, Orders of magnitude (time), 13. Climate action, Space and Planetary Science, cosmic radiation: galaxy, gamma ray: attenuation, time dependence, [PHYS.ASTR] Physics [physics]/Astrophysics [astro-ph], [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Astrophysics - High Energy Astrophysical Phenomena
Abstract

Some core-collapse supernovae are likely to be efficient cosmic-ray accelerators up to the PeV range, and therefore, to potentially play an important role in the overall Galactic cosmic-ray population. The TeV gamma-ray domain can be used to study particle acceleration in the multi-TeV and PeV range. This motivates the study of the detectability of such supernovae by current and future gamma-ray facilities. The gamma-ray emission of core-collapse supernovae strongly depends on the level of the two-photon annihilation process: high-energy gamma-ray photons emitted at the expanding shock wave following the supernova explosion can interact with soft photons from the supernova photosphere through the pair production channel, thereby strongly suppressing the flux of gamma rays leaving the system. In the case of SN 1993J, whose photospheric and shock-related parameters are well measured, we calculate the temporal evolution of the expected gamma-ray attenuation by accounting for the temporal and geometrical effects. We find the attenuation to be of about $10$ orders of magnitude in the first few days after the SN explosion. The probability of detection of a supernova similar to SN 1993J with the Cherenkov Telescope Array is highest if observations are performed either earlier than 1 day, or later than 10 days after the explosion, when the gamma-ray attenuation decreases to about $2$ orders of magnitude., Accepted to MNRAS, 7 pages, 7 figures

Published
2020

43. The Impact of Critical Reflective Inquiry Education on Experienced Nurses' Insights Into Practice

Author

Patricia A. Dwyer, Julee R Bolg, Dennis P. Doherty, Shelly Pignataro, and Ashley M Renaud

Subjects
Quality management, Leadership and Management, Writing, education, Operating Room Nursing, Education, InformationSystems_GENERAL, 03 medical and health sciences, 0302 clinical medicine, Succession planning, Humans, Narrative, 030212 general & internal medicine, Inquiry education, Staff Development, Reflection (computer graphics), Medical education, Narration, 030504 nursing, Professional development, Middle Aged, Quality Improvement, Knowledge, Review and Exam Preparation, Fundamentals and skills, 0305 other medical science, Psychology, Knowledge transfer
Abstract

Successful succession planning necessitates use of innovative strategies to encourage and support knowledge recovery and transfer. This quality improvement project evaluated the impact of a critical reflective inquiry workshop on experienced nurses' insights into practice. Nurses assessed written clinical narratives using the Critical Reflective Inquiry Assessment Tool before and after the workshop. Guided reflection led by nursing professional development practitioners fostered insight into practice, which is an essential step in supporting knowledge transfer to novice nurses.

Published
2020

44. Would SN1993J Have Been Detected by Next-generation Cerenkov Instruments?

Author

Vikram V. Dwarkadas, P. Cristofari, Gwenael Giacinti, V. Tatischeff, M. Renaud, A. Marcowith, Laboratoire Univers et Particules de Montpellier (LUPM), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)

Subjects
Physics, [PHYS]Physics [physics], 010308 nuclear & particles physics, Astrophysics::High Energy Astrophysical Phenomena, 0103 physical sciences, Astronomy, Astrophysics::Solar and Stellar Astrophysics, General Medicine, Gamma-ray astronomy, Astrophysics::Cosmology and Extragalactic Astrophysics, 010303 astronomy & astrophysics, 01 natural sciences, Astrophysics::Galaxy Astrophysics
Abstract

International audience; Already in the first days after the explosion of a supernova, the strong shock expanding forward into the dense wind of the progenitor star can theoretically accelerate particles up to the ~PeV (=1015 eV) range. These accelerated particles, interacting with the dense wind material, should lead to the production of gamma-rays in the 1–100 TeV range, through pion production. However, no supernova has yet been detected by current Cerenkov instruments, and the question of the detectability of extragalactic supernovae in nearby galaxies (within a few Mpc) by next generation instruments is still open. The detection in the TeV range is especially hindered by the two-photon annihilation process, in which high-energy gamma-rays interact with soft photons from the photosphere to produce electron/positron pairs, thereby degrading the gamma-ray signal from the system. We calculate the temporal evolution of the expected gamma-ray attenuation in the well-studied type IIb SN 1993J, accounting for both temporal and geometrical effects.

Published
2020

45. New measurement of $^{12}$C+$^{12}$C fusion reaction at astrophysical energies

Author

W P, Tan, A, Boeltzig, C, Dulal, R J, deBoer, B, Frentz, S, Henderson, K B, Howard, R, Kelmar, J J, Kolata, J, Long, K T, Macon, S, Moylan, G F, Peaslee, M, Renaud, C, Seymour, G, Seymour, B, Vande Kolk, M, Wiescher, E F, Aguilera, P, Amador-Valenzuela, D, Lizcano, and E, Martinez-Quiroz

Subjects
Astrophysics::High Energy Astrophysical Phenomena, Astrophysics::Solar and Stellar Astrophysics, FOS: Physical sciences, Nuclear Experiment (nucl-ex), Nuclear Experiment
Abstract

Carbon and oxygen burning reactions, in particular, $^{12}$C+$^{12}$C fusion, are important for the understanding and interpretation of the late phases of stellar evolution as well as the ignition and nucleosynthesis in cataclysmic binary systems such as type Ia supernovae and x-ray superbursts. A new measurement of this reaction has been performed at the University of Notre Dame using particle-$\gamma$ coincidence techniques with SAND (a silicon detector array) at the high-intensity 5U Pelletron accelerator. New results for $^{12}$C+$^{12}$C fusion at low energies relevant to nuclear astrophysics are reported. They show strong disagreement with a recent measurement using the indirect Trojan Horse method. The impact on the carbon burning process under astrophysical scenarios will be discussed., Comment: accepted for publication in Phys. Rev. Lett

Published
2020
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46. Detection of very-high-energy γ -ray emission from the colliding wind binary η Car with H.E.S.S

Author

E. O. Angüner, Ramin Marx, M. Panter, U. Katz, G. Heinzelmann, Iryna Lypova, S. Nakashima, Yvonne Becherini, G. Martí-Devesa, Stefan Klepser, H. Yoneda, A. Fiasson, L. Giunti, P. deWilt, J. King, R. Adam, I. Jung-Richardt, James Davies, F. Eichhorn, Michael Punch, Maria Haupt, R. J. Tuffs, Michal Ostrowski, J.-P. Lenain, Stefan Ohm, Łukasz Stawarz, J. F. Glicenstein, Frank M. Rieger, Markus Holler, Michelle Tsirou, C. Levy, S. Pita, S. Colafrancesco, L. Rinchiuso, Q. Remy, Felix Jankowsky, J. Zorn, M.-H. Grondin, Mischa Breuhaus, C. Arcaro, Stefano Gabici, F. Niederwanger, Jacco Vink, Sabrina Casanova, Halim Ashkar, M. Curyło, Stefan Funk, Alicja Wierzcholska, Gavin Rowell, M. Bryan, Felix Aharonian, N. Shafi, R. D. Parsons, H. Ndiyavala, B. van Soelen, B. Rudak, Dmitriy Kostunin, K. Nakashima, Nu. Komin, Natalia Żywucka, M. de Naurois, T. Chand, Jhilik Majumdar, L. Oakes, A. Lemière, Heinrich J. Völk, M. Renaud, R. Rauth, Axel Donath, A. W. Chen, M. Büchele, S. Eschbach, M. Barnard, Marek Jamrozy, J. Bolmont, Gianluca Giavitto, K. Bernlöhr, Helene Sol, V. Poireau, H. Odaka, M. Füßling, Jacek Niemiec, Rafal Moderski, C. Perennes, K. Egberts, Dieter Horns, Olaf Reimer, M. Lemoine-Goumard, J. Dyks, Ruizhi Yang, Francois Brun, Reinhard Schlickeiser, Zorawar Wadiasingh, M. Böttcher, Michael Kreter, S. Chandra, Paolo Marchegiani, P. Vincent, S. J. Fegan, A. Djannati-Ataï, V. Barbosa Martins, S. Raab, L. Dirson, F. Gaté, Kirsty Feijen, S. Bonnefoy, Constantin Steppa, Alexandre Marcowith, M. Zacharias, Rachel Simoni, Masanori Arakawa, Celine Armand, Thomas Murach, Joachim Hahn, T. Vuillaume, A. Schulz, Clemens Hoischen, A. A. Zdziarski, Ullrich Schwanke, V. Joshi, V. Sahakian, A. Carosi, F. Werner, F. Ait Benkhali, E. de Oña Wilhelmi, Anton Dmytriiev, Isak Delberth Davids, S. Schwemmer, Arnaud Mares, Andrea Santangelo, Jim Hinton, Roberta Zanin, C. Trichard, S. Sailer, Dmitry Khangulyan, P. J. Meintjes, Tom Armstrong, Matteo Cerruti, D. A. Sanchez, M. Seglar-Arroyo, P.-O. Petrucci, Johan Bregeon, R. J. White, J. Devin, F. Schüssler, M. Scalici, A. Priyana Noel, Domenico Tiziani, D. Malyshev, Tadayuki Takahashi, A.M. Taylor, Werner Hofmann, Michael Backes, Jonathan Mackey, Victor Doroshenko, Gilles Henri, Heike Prokoph, C. Moore, Q. Piel, Dorit Glawion, Tim Holch, E. Moulin, Tomasz Bulik, S. Caroff, D. Huber, Marion Spir-Jacob, G. Maurin, H. Iwasaki, A.S. Seyffert, Naomi Tsuji, D. Jankowsky, Gerard Fontaine, M. Katsuragawa, Andreas Quirrenbach, Hester Schutte, Riaan Steenkamp, Andreas Specovius, Christian Stegmann, Stefan Wagner, Yasunobu Uchiyama, L. Mohrmann, C. van Rensburg, Misao Sasaki, D. J. van der Walt, M. Hörbe, T. Tavernier, E. Leser, P. T. O'Brien, B. Khélifi, G. Hermann, Regis Terrier, Carlo Romoli, Christo Venter, Y. A. Gallant, Atreyee Sinha, C. van Eldik, A. Zech, M. Mohamed, Garret Cotter, D. A. Prokhorov, K. Kosack, B. Peyaud, G. Pühlhofer, A. Reimer, Pierre Brun, Jean-Pierre Ernenwein, Johannes Veh, R. Blackwell, E. Ruiz-Velasco, G. Emery, S. Saito, Thomas Bylund, M. Tluczykont, Armelle Jardin-Blicq, Jacques Muller, Samuel Timothy Spencer, H. Abdalla, M. A. Kastendieck, G. Vasileiadis, Włodek Kluźniak, Krzysztof Katarzynski, Catherine Boisson, Christoph Deil, Mohanraj Senniappan, D. Berge, Paul J. Morris, Kleopas Shiningayamwe, Lenka Tomankova, Jason John Watson, V. Marandon, D. Gottschall, Thomas Lohse, G. Lamanna, Alexander von Humboldt Foundation, Southern California Earthquake Center, EGI Foundation, Science and Technology Facilities Council (UK), Australian Research Council, German Research Foundation, Japan Society for the Promotion of Science, University of Amsterdam, Federal Ministry of Education and Research (Germany), Austrian Science Fund, Knut and Alice Wallenberg Foundation, Max Planck Society, National Science Centre (Poland), Centre National de la Recherche Scientifique (France), Commissariat à l'Ènergie Atomique et aux Ènergies Alternatives (France), Helmholtz Association, National Commission on Research Science and Technology (Namibia), University of Namibia, Federal Ministry of Education, Science and Research (Austria), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Univers et Théories (LUTH (UMR_8102)), Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), H.E.S.S., Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France -Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France, H.E.S.S. Collaboration, Faculty of Science, High Energy Astrophys. & Astropart. Phys (API, FNWI), Gravitation and Astroparticle Physics Amsterdam, and Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2)

Subjects
individual: η CarStars: Wolf-Rayet [Stars], Photon, stars: individual: η Car, Astrophysics::High Energy Astrophysical Phenomena, Flux, Cosmic ray, Astrophysics, 01 natural sciences, cosmic rays, 0103 physical sciences, individual: η Car [stars], High Energy Stereoscopic System, 010303 astronomy & astrophysics, Cosmic rays, Colliding-wind binary, Astroparticle physics, Physics, Spectral index, non-thermal [Radiation mechanisms], [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], general [Binaries], 010308 nuclear & particles physics, Astronomy and Astrophysics, radiation mechanisms: non-thermal, Wolf-Rayet [stars], binaries: general, 13. Climate action, Space and Planetary Science, [SDU]Sciences of the Universe [physics], astroparticle physics, ddc:520, HESS - Abteilung Hinton, stars: Wolf-Rayet, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Stars: individual: η CarStars: Wolf-Rayet, Noise (radio)
Abstract

Aims. Colliding wind binary systems have long been suspected to be high-energy (HE; 100 MeV < E < 100 GeV) {\gamma}-ray emitters. {\eta} Car is the most prominent member of this object class and is confirmed to emit phase-locked HE {\gamma} rays from hundreds of MeV to ~100 GeV energies. This work aims to search for and characterise the very-high-energy (VHE; E >100 GeV) {\gamma}-ray emission from {\eta} Car around the last periastron passage in 2014 with the ground-based High Energy Stereoscopic System (H.E.S.S.). Methods. The region around {\eta} Car was observed with H.E.S.S. between orbital phase p = 0.78 - 1.10, with a closer sampling at p {\approx} 0.95 and p {\approx} 1.10 (assuming a period of 2023 days). Optimised hardware settings as well as adjustments to the data reduction, reconstruction, and signal selection were needed to suppress and take into account the strong, extended, and inhomogeneous night sky background (NSB) in the {\eta} Car field of view. Tailored run-wise Monte-Carlo simulations (RWS) were required to accurately treat the additional noise from NSB photons in the instrument response functions. Results. H.E.S.S. detected VHE {\gamma}-ray emission from the direction of {\eta} Car shortly before and after the minimum in the X-ray light-curve close to periastron. Using the point spread function provided by RWS, the reconstructed signal is point-like and the spectrum is best described by a power law. The overall flux and spectral index in VHE {\gamma} rays agree within statistical and systematic errors before and after periastron. The {\gamma}-ray spectrum extends up to at least ~400 GeV. This implies a maximum magnetic field in a leptonic scenario in the emission region of 0.5 Gauss. No indication for phase-locked flux variations is detected in the H.E.S.S. data., Comment: 9 pages, 4 figures, 3 tables, in press with A&A

Published
2020

47. Resolving the Crab pulsar wind nebula at teraelectronvolt energies

Author

Natalia Żywucka, M. de Naurois, T. Chand, Frank M. Rieger, J. Bolmont, S. Colafrancesco, Ruizhi Yang, W. Kluźniak, S. Eschbach, Jim Hinton, R. Simoni, Dmitry Khangulyan, Christopher J. Moore, G. Fontaine, M. Büchele, D. A. Sanchez, T. Tavernier, L. Mohrmann, Denys Malyshev, J. Veh, S. Klepser, B. Khélifi, H. M. Schutte, C. Perennes, D. Glawion, Christoph Deil, Mohanraj Senniappan, A.A. Zdziarski, A. Djannati-Ataï, Y.A. Gallant, Gavin Rowell, Stefan Funk, T. Takahashi, Gianluca Giavitto, Axel Donath, A. W. Chen, M. Bryan, J. Dyks, D. Zaborov, I. Oya, G. Heinzelmann, K. Shiningayamwe, T. Lohse, Yvonne Becherini, M. Renaud, H. Iwasaki, M. Holler, J.-P. Ernenwein, P. Vincent, R. D. Parsons, G. Emery, H. Odaka, Christo Venter, D. Huber, M. Arakawa, D. Berge, M. Capasso, Matteo Cerruti, Nachiketa Chakraborty, F. Niederwanger, A. Marcowith, A. Zech, E. Leser, Jacco Vink, R. Rauth, Sabrina Casanova, C. Arcaro, I. Jung-Richardt, T. Vuillaume, G. Hermann, D. Gottschall, Werner Hofmann, Regis Terrier, J. Becker Tjus, A. Schulz, Carlo Romoli, M. Panter, M. Seglar-Arroyo, H. Ndiyavala, B. van Soelen, Felix Aharonian, M. Haupt, Lukasz Stawarz, Michael Punch, V. Doroshenko, M. Spir-Jacob, R. Tuffs, R. C. G. Chaves, E. O. Angüner, A. Priyana Noel, L. O'c. Drury, S. Saito, J.F. Glicenstein, D. J. van der Walt, S. Raab, Andreas Quirrenbach, C. Steppa, J.-P. Lenain, N. Shafi, K. Egberts, Robert Wagner, K. Kosack, J. Hahn, Reinhard Schlickeiser, M. Tsirou, G. Vasileiadis, M. Kraus, S. Chandra, S. Nakashima, G. Martí-Devesa, M. Katsuragawa, Ruben Lopez-Coto, M.-H. Grondin, M. Böttcher, R. Blackwell, E. Ruiz-Velasco, L. Dirson, Stefan Ohm, Léa Jouvin, S. Pita, F. Schüssler, P. deWilt, J. King, F. Voisin, Julien Lefaucheur, A. Dmytriiev, R. Moderski, S. Gabici, A. Fiasson, J. Lau, L. Oakes, I.D. Davids, Alison Mitchell, L. Rinchiuso, P.J. Meintjes, Heike Prokoph, Zorawar Wadiasingh, R. J. White, S. Fegan, Dieter Horns, V. Poireau, Monica Barnard, P.-O. Petrucci, H. Abdalla, D. Jankowsky, Q. Piel, C. Stegmann, Nu. Komin, Marek Jamrozy, Catherine Boisson, Helene Sol, Pierre Brun, A.S. Seyffert, A. Carosi, M. Füßling, M.A. Kastendieck, S. Bonnefoy, N. Tsuji, F. Gaté, J. Devin, G. Henri, D. A. Prokhorov, D. Tiziani, C. Hoischen, Ullrich Schwanke, A. Specovius, R. Steenkamp, A. Reimer, J. Bregeon, Francois Brun, B. Condon, Michael Backes, H. Yoneda, Tim Holch, M. Tluczykont, E. Moulin, Tomasz Bulik, T. Bylund, A. Jacholkowska, S. Caroff, Celine Armand, F. Jankowsky, Stefan Wagner, Yasunobu Uchiyama, C. van Rensburg, M. Zacharias, C. Trichard, F. Ait Benkhali, Manami Sasaki, S. Schwemmer, Andrea Santangelo, A. Ziegler, G. Maurin, A. Wierzcholska, C. Mariaud, Jacek Niemiec, Olaf Reimer, Thomas Murach, A. Lemière, M. Lemoine-Goumard, I. Shilon, Heinrich J. Völk, R. Marx, P. Bordas, I. Lypova, G. Lamanna, J. Zorn, U. Katz, J.-P. Tavernet, B. Rudak, V. Marandon, K. Katarzyński, A.M. Taylor, V. Sahakian, M. Mohamed, M. Ostrowski, Konrad Bernlöhr, B. Peyaud, G. Pühlhofer, R. Zanin, P. T. O'Brien, Atreyee Sinha, C. van Eldik, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France -Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France, H.E.S.S., Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), European Commission, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), Armagh Observatory, Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Faculty of Science, High Energy Astrophys. & Astropart. Phys (API, FNWI), Gravitation and Astroparticle Physics Amsterdam, 26598973 - Abdalla, Hassan, 30588766 - Arcaro, Cornelia, 28644743 - Backes, Michael, 20574266 - Barnard, Monica, 24420530 - Böttcher, Markus, 30366755 - Chand, Tej B., 31125417 - Chandra, Sunil, 26403366 - Ndiyavala, Hambeleleni, 10060499 - Van der Walt, Diederick Johannes, 12006653 - Venter, Christo, 26594080 - Wadiasingh, Zorawar, 22799133 - Schutte, Hester M., 20126999 - Seyffert, Albertus Stefanus, 29092086 - Zacharias, Michael, and Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
010504 meteorology & atmospheric sciences, Electromagnetic spectrum, electron: relativistic, magnetic field, Astrophysics, positron: energy, 01 natural sciences, 7. Clean energy, Pulsar wind nebula, particle: acceleration, Raigs gamma, Astrophysics::Solar and Stellar Astrophysics, HESS - Abteilung Hofmann, 010303 astronomy & astrophysics, ComputingMilieux_MISCELLANEOUS, pulsar, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, [PHYS]Physics [physics], Nebula, radio wave, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], 4. Education, [SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], photon, Gamma ray, Astrophysics::Instrumentation and Methods for Astrophysics, High-energy astrophysics, Particle astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Camps magnètics, accelerator, High-energy astronomy, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, gap, X-ray, energy loss: rotation, Pulsar, 0103 physical sciences, synchrotron, Astrophysics::Galaxy Astrophysics, gamma ray: energy, 0105 earth and related environmental sciences, Crab Pulsar, Gamma rays, Astronomy and Astrophysics, Crab Nebula, electromagnetic, gamma ray: VHE, [SDU]Sciences of the Universe [physics], Magnetic fields, ddc:520, Physics::Accelerator Physics
Abstract

arXiv:1909.09494v2, H.E.S.S. Collaboration: et al., The support of the Namibian authorities and of the University of Namibia in facilitating the construction and operation of H.E.S.S. is gratefully acknowledged, as is the support by the German Ministry for Education and Research (BMBF), the Max Planck Society, the German Research Foundation (DFG), the Helmholtz Association, the Alexander von Humboldt Foundation, the French Ministry of Higher Education, Research and Innovation, the Centre National de la Recherche Scientifique (CNRS/IN2P3 and CNRS/INSU), the Commissariat à l’énergie atomique et aux énergies alternatives (CEA), the UK Science and Technology Facilities Council (STFC), the Knut and Alice Wallenberg Foundation, the National Science Centre, Poland (grant number 2016/22/M/ST9/00382), the South African Department of Science and Technology and the National Research Foundation, the University of Namibia, the National Commission on Research, Science and Technology of Namibia (NCRST), the Austrian Federal Ministry of Education, Science and Research and the Austrian Science Fund (FWF), the Australian Research Council (ARC), the Japan Society for the Promotion of Science and the University of Amsterdam. We appreciate the excellent work of the technical support staff in Berlin, Zeuthen, Heidelberg, Palaiseau, Paris, Saclay, Tübingen and Namibia in the construction and operation of the equipment. This work benefited from services provided by the H.E.S.S. Virtual Organisation, supported by the national resource providers of the EGI Federation. R.C.G.C. was funded by EU FP7 Marie Curie (grant agreement number PIEF-GA-2012-332350).

Published
2020

48. The Notre-Dame Cube: An active-target time-projection chamber for radioactive beam experiments and detector development

Author

T. Ahn, J.S. Randhawa, S. Aguilar, D. Blankstein, L. Delgado, N. Dixneuf, S.L. Henderson, W. Jackson, L. Jensen, S. Jin, J. Koci, J.J. Kolata, J. Lai, J. Levano, X. Li, A. Mubarak, P.D. O’Malley, S. Ramirez Martin, M. Renaud, M.Z. Serikow, A. Tollefson, J. Wilson, and L. Yan

Subjects
Nuclear and High Energy Physics, Physics - Instrumentation and Detectors, Physics::Instrumentation and Detectors, 010308 nuclear & particles physics, fungi, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), 01 natural sciences, 0103 physical sciences, Physics::Accelerator Physics, Nuclear Experiment (nucl-ex), 010306 general physics, Nuclear Experiment, Instrumentation
Abstract

Active-target detectors have the potential to address the difficulties associated with the low intensities of radioactive beams. We have developed an active-target detector, the Notre Dame Cube (ND-Cube), to perform experiments with radioactive beams produced at $\mathit{TwinSol}$ and to aid in the development of active-target techniques. Various aspects of the ND-Cube and its design were characterized. The ND-Cube was commissioned with a $^{7}$Li beam for measuring $^{40}$Ar + $^{7}$Li fusion reaction cross sections and investigating $^{7}$Li($\alpha$,$\alpha$)$^{7}$Li scattering events. The ND-Cube will be used to study a range of reactions using light radioactive ions produced at low energy., Comment: 13 pages, 12 figures

Published
2022

49. Reproducible Quantification of Regional Sympathetic Denervation with [

Author

Jean Z, Wang, Jonathan B, Moody, Nicole, Kaps, Deron, Britt, Aaryn, Lavallee, Jennifer M, Renaud, Jason G E, Zelt, Kai Yi, Wu, Rob S, Beanlands, James A, Fallavollita, John M, Canty, and Robert A, deKemp

Subjects
Ephedrine, Male, Observer Variation, Contrast Media, Reproducibility of Results, Heart, Middle Aged, Article, Cardiac Imaging Techniques, Surgery, Computer-Assisted, Positron-Emission Tomography, Humans, Female, Sympathectomy, Software, Aged, Retrospective Studies
Abstract

BACKGROUND: Regional cardiac sympathetic denervation is predictive of sudden cardiac arrest in patients with ischemic cardiomyopathy. The reproducibility of denervation scores between automated software programs has not been evaluated. This study seeks to: 1) compare the inter-rater reliability of regional denervation measurements using two analysis programs: FlowQuant® and Corridor4DM®; 2) evaluate test-retest repeatability of regional denervation scores. METHODS: N=190 dynamic [(11)C]meta-hydroxyephedrine (HED) PET scans were reviewed from the PAREPET trial in ischemic cardiomyopathy patients with reduced left ventricular ejection fraction(LVEF≤35%). N=12 scans were excluded due to non-diagnostic quality. N=178 scans were analyzed using FlowQuant and Corridor4DM software, each by two observers. Test-retest scans from n=20 patients with stable heart failure were utilized for test-retest analysis. Denervation scores were defined as extent×severity of relative uptake defects in LV regions with

Published
2019

50. Saline-push improves rubidium-82 PET image quality

Author

Kai Yi Wu, Kimberly Gardner, Jennifer M. Renaud, May Aung, Robert A. deKemp, and Rob S. Beanlands

Subjects
Male, Rubidium-82, positron emission tomography, Image quality, medicine.medical_treatment, continuous quality improvement, Coronary Artery Disease, 030204 cardiovascular system & hematology, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Myocardial perfusion imaging, 0302 clinical medicine, Superior vena cava, medicine, Humans, Radiology, Nuclear Medicine and imaging, Saline, Aged, Radioisotopes, medicine.diagnostic_test, business.industry, Brief Report, Stroke Volume, Middle Aged, myocardial perfusion imaging, medicine.anatomical_structure, Ventricle, Positron emission tomography, Positron-Emission Tomography, cardiovascular system, Female, Saline Solution, Cardiology and Cardiovascular Medicine, business, Nuclear medicine, Rubidium Radioisotopes, Venous cannulation
Abstract

Introduction Rubidium-82 (82Rb) PET is used widely for myocardial perfusion imaging. The purpose of this study was to investigate if an additional saline-push following the 82Rb elution improves PET image quality. Methods 82Rb PET scans were acquired with and without 26 mL saline-push in six patients as part of a clinical quality improvement program. Dynamic images were analyzed to measure the total activity delivered to the superior vena cava (SVC) and retained in the left ventricle (LV) myocardium. Tracer uptake images were used to measure blood background coefficient-of-variation (COV), myocardium-to-blood signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) to assess image quality. Results Similar eluted activity was measured with/without the saline-push (830 vs 795 MBq; P = 0.24). The activity delivered to the heart and retained in the myocardium was consistently increased more than twofold (SVC: + 114% and LV: + 104%; P

Published
2018

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