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Serous endometrial carcinoma is characterized by its highly aggressive nature and represents about 10% of all endometrial carcinomas. It causes about 80% of deaths among women suffering from endometrial cancer. The aim of our study was to determine the frequency, lymphatic and local spread of serous endometrial cancer compared with endometrial adenocarcinoma. Materials and methods: This was a retrospective study conducted in a period of 4 years (from 2015 to 2019). One hundred and twenty-three women aged between 39 and 84 years suffering from endometrial carcinoma in various stages according to FIGO from stage I to IV were included in the study. Diagnosis was established clinically and by imaging studies and was histologically proven in all women. We performed radical hysterectomy type B or C (2017 Update on the Querleu-Morrow Classification of Radical Hysterectomy) and pelvic lymph node dissection (PN) with or without paraaortic (PAR) lymph node dissection in all patients. Results: In 106 (86.2%) patients we found adenocarcinoma, in 9 (7.3%) of them – serous carcinoma, in 4 (3.3%) women – carcinosarcoma, in 4 (3.3%) women – clear cell carcinoma. The study compared the results only of 115 (100%) women with adenocarcinoma and serous carcinoma. In 17.8% of the patients with adenocarcinoma we found the presence of lymph node metastases, and in the group of patients with serous carcinoma we found lymph node metastases in 77.7% of them. There was a significant difference in the frequency of lymph node metastases according to the histological type EC (p < 0.00001). In 22.6% of patients with adenocarcinoma there was a local cancer spread, while such a spread was found in 66.7% of patients with serous cancer. After statistical processing of the results, we found a significant difference in the frequency of local tissue spread depending on the histological type of EC. Conclusion: Patients with serous endometrial cancer have significant more frequent lymphatic metastases and local spread than those with endometrial adenocarcinoma.

The present research featured the social structure of the Pskov Province in the 1760s. The cities of Pskov and Velikiye Luki were the two most densely populated areas in the region, but this study also covered the less populated Gdov urban area. The author relied on church records, e.g. confession lists and metric books, from the State Archive of the Pskov Province. The research also included original and scientifically processed audit descriptions. They proved to be a novel and extensive source of data that made it possible to describe the demographic and social structure of pre-revolutionary provincial Russia. The analysis revealed the quantitative, gender, income, and religious characteristics of the local population in the 1780s. The population of the Pskov Province was mainly represented by Russians peasants, especially in the area of Velikiye Luki. Velikiye Luki and Pskov had an exceptionally large number of peasant city-dwellers, which was untypical for the provincial society of that time. In general, the 1760s saw a considerable growth of taxable population in the Pskov Province.

Urbanized territories are subject to high anthropogenic pressure. The most dangerous pollutants are oil products and heavy metals. However, the study of their joint influence on soil properties has not been carried out in detail. In this work, the combined effect of oil products and heavy metals on soil phytotoxicity was determined. The experiment was carried out on model systems. It was found that with a small amount of heavy metal pollution, the leading factor in the phytotoxic effect is oil pollution. With significant pollution by heavy metals and oil products, the phytotoxic effect is additive in nature from the content of these pollutants. Using the software package STATISTICA 8.0, the mathematical dependence of phytotoxicity on the content of oil products and heavy metals was determined.

The article presents reviews of modern domestic and foreign scientific publications on the pathogenesis of atrial fibrillation (AF) in patients with arterial hypertension (AH), as well as the issues of blood pressure control in AF. Arterial hypertension (AH) is often accompanied by comorbidity, and, in addition, is the most frequent factor in the development of atrial fibrillation (AF). AF is the most common type of arrhythmia, which increases the risk of thromboembolic complications, heart failure, and leads to an increase in the overall mortality rate. The aim of the work was to study the pathological mechanisms of the formation of AF in hypertension, as well as their mutual impact on the course of diseases, and, in addition, to analyze and compare methods for measuring blood pressure (BP) in AF, used in modern clinical work, to identify the most objective method. A general scientific method was applied: analysis of modern scientifi c domestic and foreign literature on research problems, generalization, comparison, systematization of theoretical data on the experience of application. All reviews were indexed in PubMed, Medline, eLibrary, CyberLeninka, Google Scholar databases. The presented study allow us to conclude that hypertension is both a risk factor for atrial fi brillation and a complication of the course of the disease in patients with atrial fibrillation; the most objective method of measuring blood pressure in AF is oscillometric. The tasks and prospects of future research are identified.

Research subject. The article presents the results of a comprehensive study of a column of organomineral deposits (750 cm) in the tract of Lake Peschanoe (Amur Region, between the Amur and Zeya rivers).Material and methods. In the studied section, the composition of organomineral deposits were examined based on radiocarbon dating and palynological analysis.Results. According to radiocarbon dating, the sedimentation began over 4 thousand calendar years. Specific features of the accumulation and distribution of rock-forming oxides and microelements along the organomineral sedimentary profile were established. The mineral composition is dominated by quartz, feldspars, amphiboles, pyrite, garnet and biotite. The highest values of the scattering coefficient in the thickness of the deposits are typical of Hg (8.0), Tl (6.7), La (5.3), below – Zr, Rb and Li (4.7, 4.4 and 4.1, respectively).Conclusions. The study of the geochemical characteristics of organomineral deposits allowed us to identify the industrial period of sedimentation, which was characterized by an increase in the concentrations of Hg, Cd, Pb and Sn. The background contents of elements in the organomineral deposits of the Lake Peschanoe tract can be used as a regional background for deposits in the transboundary territory of the Upper and Middle Amur and its tributaries. The calculated geochemical coefficients indicate the freshwater content of the basin and the alternation of stagnant and oxidizing environments during sedimentation. The increased Ca/Sr values are associated with a change in the climatic regime towards cooling, which occurred during the last 4 thousand years in this area: 4300–4100, 2400–2100, 500–230 years ago.

The statistical characteristics of the day-to-day variability of the F2-layer peak electron number density, NmF2, measured by the mid-latitude Dourbes and Juliusruh ionosondes are studied for each month, M, in a year for geomagnetically quiet conditions at low solar activity during the time periods from 1957 to 2017. The NmF2 statistical parameters under study are the mathematical expectation NmF2E, the most probable NmF2MP, the arithmetical mean monthly median NmF2MED, and the variation coefficients CVE(UT,M), CVMP(UT,M), and CVMED(UT,M) of NmF2 relative to NmF2E, NmF2MP, and NmF2MED, respectively, where UT is the universal time. It is found that the values of CVE(UT,M), CVMED(UT,M), and CVMP(UT,M) are changed in the intervals of 14–48%, 14–62%, and 14–120%, respectively. In the predominant majority of cases, the coefficient CVE(UT,M) does not exceed the coefficients CVMED(UT,M) or CVMP(UT,M). If CVE(UT,M) > CVMED(UT,M) or CVE(UT,M) > CVMP(UT,M) then the difference between CVE(UT,M) and CVMED(UT,M) or between CVE(UT,M) and CVMP(UT,M) is not significant in comparison with their values. Thus, as a quantitative characteristic that provides the best description of a set of observations of NmF2 by one parameter, one should use the mathematical expectation of NmF2, but not the monthly median of NmF2 or the most probable NmF2. Empirical models of NmF2 should be based on the mathematical expected NmF2, but not on the monthly median of NmF2 or the most probable NmF2.

The journal “Sevemy Vestnik”, around which relatively young Petersburg writers — A. Volynsky, N. Minsky, D. Merezhkovsky and Z. Gippius, F. Sologub — were grouped in the last years of the 19th century, was of exceptional importance for the early stage of Russian Symbolism. The article continues the previously begun publication of new materials from the archive of the publisher (since 1891) of the “Severny Vestnik”, Lyubov Gurevich. Two documents from the funds of the RGALI and the Manuscript Division of the IRL RAS — “Lovely Memories” and a note on the reorganization of the journal (1897–1898) — are presented. They are a kind of factual basis and addition to her article “Symbolism of the 1890s and the journal 'Severny Vestnik'” (presented in the first part of the publication: Literaturnyi fakt, no. 1 (19), 2021). Gurevich tells about the financial, organizational and censorship difficulties of keeping the journal and about complicated relationships in the circle of its authors and editors. The appendix contains Gurevich’s letter dated 1891 to her father where she admits that she is attracted by journalism and literary work “more than anything else”, and asks for financial help to buy out the collapsing journal and become the publisher of “Severny Vestnik” herself. Documents introduced into scientific circulation allow expanding the range of sources for studying the history of journalism and early Russian modernism.

Objective. To study both the molecular discrimination of D-tartrate fermenting and non-fermenting strains of Salmonella enterica subsp. enterica serotype Paratyphi B isolated from patients with paratyphoid fever and the clinical course of this disease. Materials and methods. The isolates examined were from children aged 3 months to 9 years. A total of 33 Salmonella strains were serotyped as Salmonella Paratyphi B, with an antigenic formula based on O- and H- antigens: 1,4, [5], 12: b: 1,2 by Kauffmann–White classification. Results. Multiplex PCR analysis confirmed all tested strains as d-tartrate fermenting (dT+), also referred to as variant Java. Discussion. We found that the most common cause of paratyphoid fever among children in Bulgaria is variant Java Salmonella Paratyphi B. Most children had classic symptoms of acute gastroenteritis – fever, watery diarrhea and vomiting.

The journal “Severny Vestnik” (1891 –1898), around which relatively young Petersburg writers — A. Volynsky, N. Minsky, D. Merezhkovsky and Z. Gippius, F. Sologub — were grouped in the last years of the 19th century, was of exceptional importance for the early stage of Russian Symbolism. The publication presents new archival materials on the history of the journal: an article “Symbolism of the 1890s and the journal 'Severny Vestnik'” by L.Ya. Gurevich, prepared for an unpublished collection of articles “Russian Symbolism” edited by N.K. Gudzii and read in the form of a report at a meeting of the Literary Subsection of the State Academy of Arts, as well as the minutes of the meeting dated May 14, 1926 with the discussion of this report. An addition to L. Gurevich’s article is her notes (1897 –1898), which record the real and biographical context of the publication of “Severny Vestnik” from the moment the journal passed into her hands until it was closed, as well as her plan for reorganizing the journal. These materials will be presented in the second part of the publication. Documents introduced into scientific circulation allow expanding the range of sources for studying the history of “Severny Vestnik” and early Russian Symbolism.

In order to save the cost of expensive compound feed, a number of biologically active substances (vitamins and amino acids) and improve the digestibility of nutrients for the first time in poultry meat using laser technology there is a real possibility of “transferring” the studied amino acids (methionine, glycine) and all water-soluble vitamins using a laser beam through the skin in the breast area of broiler chickens. The research has been carried out in Belgrankorm-Veliky Novgorod LLC in the Krestetsky district in the Novgorod region with a large-cage housing method of broiler chickens of the cross Hubbard. The duration of broilers rearing was 39 days, 4 recipes of compound feed based on wheat grain, corn, soybeen meal with the inclusion of fish flour, sunflower oil, corn gluten, sunflower meal, meat and bone meal and mineral additives (monocalcium phosphate, lime flour) have been used. For better assimilation of nutrients and biologically active substances by the body amino acids (methionine, glycine) and water-soluble vitamins Undevit, both individually and in combination with them in a ratio of 1:1 (by weight), in the form of powders passed through an infra-red laser beam in a spatial modulator, which were attached to two emitters (simultaneously) of the “Uzor-2K-Super” laser in the chest area have been used. Broilers of the experimental groups ate feed more often and faster than the herdmates of the control group. Air ozonation in the poultry house and broilers has been carried out in a mobile way using the Rios ozonator of the Decont series (mode 3, with a capacity of 20 g/m3 ). Innovative methods of influencing on the body caused the increase in the intensity of metabolic processes, growth and development, fattening and meat traits, and feed conversion in broilers.

Relevance of the work. Bromine is a tolassophilic, organophilic and essential element. The combination of natural and anthropogenic sources of dispersion of this element determines the complexity and multifactorial nature of its entry into the environment, affects the characteristics of halogen accumulation and distribution in natural environments. The main attention in the work is focused on urbanized areas of the local and regional levels of the study with sources of Br emission. The migration routes and biogeochemical accumulation of bromine remain poorly studied issues. The main aim of the research is to determine the quantitative content of Br in the leaves of woody plants of the genus poplar (Populus L.), growing in urbanized areas of South-East Eurasia, and based on the principles of biogeochemical zoning to identify the halos of Br load, determine the main factors of their formation. Methods. Poplar leaves (Populus L.) served as the object of the study. Sampling was carried out in August 2015–2018 on the territory of more than 50 cities along a uniform network with a step of 1×1 and 2×2 km. The average sample size in cities was 30 samples. In total, about 1700 samples of poplar leaves were taken. Leaf ash was carried out by dry mineralization in a muffle furnace at 450 °C for 5 hours. The authors have taken into account the literature data that Br loss in the ash obtained at 400 °C was no more than 20 % of the calculated value. Content of Br and other chemical elements in the ash of poplar leaves was determined by the method of instrumental neutron activation analysis in the nuclear geochemical laboratory at the educational research nuclear reactor (IRT-T) at Tomsk Polytechnic University. The analysis results were processed using descriptive statistics, cluster and discriminant analyzes. Results. The average Br content in the ash of poplar leaves in urbanized areas was 56,5±2,1 mg/kg, with a range from 0,3 to 1730,1 mg/kg. The median is 30,6 mg/kg. The lower anomalous Br content was 103,4 mg/kg. Two conjugated anomalous bromine biogeochemical regions were revealed: Kulunda – natural genesis and North Kazakhstan – natural and technogenic genesis. Areas are depleted in area in bromine biogeochemical subprovince, first described in this work.

The growth of production and consumption of dietary poultry meat causes an urgent need to develop and use new and more effective elements of technologically complete compound feed and broiler chicken rearing in the regions. In order to increase the range of non-traditional feed products and feed additives and reduce the deficit of raw protein, amino acids and vitamins, it is advisable to use non-traditional methods to increase the efficiency of compound feed use when broilers rearing. One of the available non-traditional methods for increasing the efficiency of using compound feed in meat production should be considered the use of synthetic amino acids for a new purpose, namely as a modulator of spatial through the infrared laser beam. The purpose of the research was to improve the industrial technology for rearing of broiler chickens using aeroionotherapy and low-intensity laser radiation. Experimental studies have been carried out under the production conditions of poultry house No. 1 (halls No. 2 and No. 3) of the Novgorodskaya poultry farm in the Novgorod region. Broiler chickens of cross Ross 508 have been kept in three-tier BKM-3B cell batteries. The use of low-intensity infrared laser radiation with minimal parameters of the “Uzor 2K-Super” laser (80 Hz wavelength) and air ionization of air oxygen (AN-1 and AI-P aeronizers, modes 2 and 3) against the background of the main diet of cross-Ross 508 broiler chickens improved the state of carbohydrate, protein, fat, amino acid, and vitamin metabolism by increasing the assimilation processes of their body. It has been caused functional activation of the digestive system in it, along with an increase in enzyme, immune and hormonal systems and made it possible to fully realize the level of meat productivity, feed-efficiency and improve some blood biochemical parameters.

The intensive development of genetics at the molecular level has now opened up the possibility for breeders to identify and study genes that are directly or indirectly related to desirable economically useful traits. The purpose of the research was to identify desirable genotypes in the breeding of Kazakh White-Headed cattle based on the genes-markers of meat productivity of calpain (CAPN1) and somatotropin (GH) for use in breeding to increase meat productivity and beef quality. Experimental researches have been carried out on steers of the Kazakh White-Headed breed on the basis of the APC collective farm “Gigant” in the Blagodarnensky district in the Stavropol Territory. Analysis of growth and development indicators of calves has shown that the value of live weight and average daily gains was higher in calves carrying the C allele at calpain gene locus and V allele at somatotropin gene locus. Dominant alleles C and V in the homozygous state characterize the desired genotype of calves. During weaning the studied indicators were higher with a diff erence on average up to 13,0 % in young animals of homozygous genotypes (CC and VV). The largest number of muscle fi bers has been observed in steers with the desired CC and VV genotypes. They outperformed their herdmates with GG genotype by 36,82 pcs/мм² or 19,7 % in calpain gene group (CAPN1) by 55,7 pcs/мм² or 31,4 % in somatotropin gene group (GH), respectively. The diameter of muscle fibers in carcasses with the desired genotype was less by 4,23 microns or 11,9 %, and by 6,82 microns or 16,8 %. The meat of steers with homozygous CC and VV alleles according to the studied genes differed from the meat of animals with GG and LL genotypes by 12,6 % in calpain gene (CAPN1) and 15,1 % in somatotropin gene (GH). The connective tissue content was higher in animals with the undesirable type of G and L alleles than in animals of the desired genotype, by 2,13 and 3,34 abs. percent’s. The area of the eye of loin in animals of desired VV genotype of somatotropin cluster (GH) was higher than in animals of CC genotype of calpain cluster (CAPN1) by 4,84 cм² or 10,1 %.

Based on model experiments on the sorption of chemical elements from multicomponent solutions with fungi biomass, lignite, and humic acids, it was assumed that qualitative changes in organic matter during the transformation of plant biomass into coal controlled the predomination of one of the sorption mechanisms. At the initial stage, the biomass of microscopic fungi may contribute to fixation of significant volumes of elements with the formation of zero-valent particles due to a combination of the mechanisms of ion exchange, chelation, and reduction reactions. Subsequently, mostly due to ion exchange, humic acids may fix significant volumes of Cu, Cr, Zn, Co, Ni, Pb, and Fe with the formation of organomineral compounds. Many fewer elements are sorbed on lignite, and this proceeds mainly by the mechanism of intermolecular interactions.

Background and anomalous rare earth element (RЕЕ) concentrations in poplar (Populus spp.) leaves in urban areas of Siberia, Russian Far East, and Kazakhstan were determined. Regions with the highest RЕЕ levels were identified. Ratios of light to middle RЕЕs are geochemical indicators of the impacts of oil refining and mining. Airborne dust transport by prevailing winds from ash and slag dumps of power plants and industrial sites, and alluvial terraces control the REE distribution in cities.

The publication introduces into scientific circulation an unknown letter from Dmitry Filosofov to Tatyana Nikolaevna Gippius (1877–1957) from the Merezhkovskys collection in the Amherst Russian Center (Massachusetts, USA). The document refers to the period of the Merezhkovskys and Filosofov’s Paris emigration in 1906–1908, being a fragment of the extensive family correspondence of the period, in which Filosofov participated as a family member. The larger part of correspondence consists of the so-called “diaries” of T.N. Gippius (her almost daily letters-reports to Paris), in which a chronicle of the inner life of the Merezhkovskys’ neo-Christian commune is traced. Response letters have been lost, with a few exceptions. Filosofov’s letter to T. Gippius captures a remarkable fact of the epistolary dialogue and relations of correspondents, contains a real commentary on a number of plots of “diary” letters, and introduces new additional touches to the picture of the Merezhkovskys and Filosofov’s Parisian life in 1906–1908.

This publication introduces the academic community to the new data from the archives of the Merezhkovskys and D. V. Filosofov, which are stored in the Amherst Center for Russian Culture (Massachusetts, USA). It presents a selection of letters by Filosofov (1906) and N. A. Berdiaev (1907) that provide new details concerning the relationship between the two. Selections from the «diaries» of T. N. Gippius (1906–1908) that shed additional light on the «Berdiaev» theme are published as an appendix.

In this article, K. M. Azadovsky analyses the reception of Fyodor Sologub’s early work (his short story The Shadows, and novel Bad Dreams) in the German-speaking world. Special attention is devoted to the Viennese translator Alexander Brauner (1871–1937), who in the 1890s was affi liated with the Young Austria group (A. Schnitzler, H. von Hofmansthal et al.). Relying on the archival data, the author traces Brauner’s personal connections with I. A. Vengerova and V. A. Vengerov, L. Ia. Gurevich and L. Andreas-Salomé. The author discusses Brauner’s articles in the journal Severnii Vestnik (The Northern Herald), his translations of Sologub’s work, and the reviews of these translations in the German press. 18 letters from A. Brauner to Sologub (1897–1912) are published as the Appendix.