9 results on '"M. Larger"'
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2. Formation basée sur la simulation en santé : conciliation des traitements médicamenteux et entretiens pharmaceutiques ciblés au sein d’un centre hospitalo-universitaire
- Author
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D. Hoegy, A.-L. Yailian, E. Delande, J. Martin, A. Baudoin, N. Poletto, S. Parat, A. Picard, M.-D. Guillemin, M. Larger, T. Novais, and A. Janoly Dumenil
- Subjects
Pharmacology (medical) - Published
- 2022
3. Identification des lacunes de connaissances des étudiants en filière officine débutant le stage de 5e année : propositions pour modifier le contenu de l’enseignement
- Author
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R. Boulieu, O. Catala, J. Grassin, Michel Tod, C. Vinciguerra, Joëlle Goudable, S. Derfoufi, Christelle Mouchoux, Benoît Allenet, B. Charpiat, Pierrick Bedouch, A. Janoly-Dumenil, M. Larger, Techniques pour l'Evaluation et la Modélisation des Actions de la Santé (TIMC-IMAG-ThEMAS), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Institut des Sciences Pharmaceutiques et Biologiques de Lyon - Département de Pharmacie Clinique, de Pharmacocinétique et d'Evaluation du Médicament, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-IMAG-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-IMAG-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)
- Subjects
Pharmacology ,03 medical and health sciences ,0302 clinical medicine ,[SDV.SP.MED]Life Sciences [q-bio]/Pharmaceutical sciences/Medication ,[SHS.EDU]Humanities and Social Sciences/Education ,Pharmaceutical Science ,[SHS.PSY]Humanities and Social Sciences/Psychology ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,030212 general & internal medicine ,030226 pharmacology & pharmacy ,ComputingMilieux_MISCELLANEOUS - Abstract
Resume Introduction Le contenu de l’enseignement dispense au cours des etudes de pharmacie doit permettre l’utilisation pratique des connaissances acquises, dans un souci d’amelioration du soin medicamenteux. L’objectif de ce travail a ete de mettre en lumiere les lacunes que presentent les etudiants de la filiere officine debutant leur stage hospitalier de 5 e annee. Methode Quatorze etudiants en stage de 5 e annee accompli dans un CHU ont ete invites a mettre en lumiere ces lacunes au fur et a mesure de leur immersion dans le soin medicamenteux. Ils l’ont fait sous l’observation attentive des praticiens hospitaliers les encadrant. Ces praticiens se sont appuyes sur des referentiels metiers, des outils documentaires employes en routine clinique et des publications leur ayant servi a asseoir leurs pratiques de soins pharmaceutiques. Resultats Les insuffisances ou lacunes identifiees ont ete : la forme et le contenu de la communication avec d’autres professionnels de sante, la forme de la communication avec les patients, la faible appropriation des outils documentaires indispensables a une pratique clinique pertinente, la meconnaissance de la codification des interventions pharmaceutiques, les risques lies au conditionnement des medicaments et les avancees et dangers lies aux technologies de l’information. Discussion Ces lacunes constituent un handicap retardant le processus qui conduit a passer du stade d’etudiant au stade de professionnel de sante. Il revient aux praticiens hospitaliers la necessite de combler ces lacunes avant immersion totale en situation de soin. Conclusion Ces resultats invitent a reviser partiellement le contenu du programme d’enseignement dispense avant la 5 e annee.
- Published
- 2016
4. [Identification of knowledge deficits of pharmacy students at the beginning of the fifth year of pharmacy practice experience: Proposals to change the content of academic programs]
- Author
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B, Charpiat, S, Derfoufi, M, Larger, A, Janoly-Dumenil, C, Mouchoux, B, Allenet, M, Tod, J, Grassin, R, Boulieu, O, Catala, P, Bedouch, J, Goudable, and C, Vinciguerra
- Subjects
Adult ,Male ,Young Adult ,Students, Pharmacy ,Education, Pharmacy ,Preceptorship ,Humans ,Female ,Curriculum ,Educational Measurement ,France ,Pharmacists ,Pharmacy Service, Hospital - Abstract
In France, community pharmacy students performed a hospital pharmacy practice experience during the 5th year of the university curriculum. The purpose of a part of the content of the academic teaching program delivered before this practice experience is to prepare the students for their future hospital activities. It should enable them for the practical use of knowledge in order to improve pharmacotherapy, laboratory diagnosis and monitoring of patients' care. The aim of this study was to show if there are gaps in this program.Fourteen students performing their clerkship in a teaching hospital were invited to highlight these gaps when they were gradually immersed in the pharmaceutical care. They did so under the careful observation of hospital pharmacist preceptors. These practitioners referred to professional guidelines, documentary tools used in daily clinical practice and publications supporting their pharmaceutical care practices.Shortcomings and gaps identified were: how to communicate with other healthcare professionals and the content of verbal exchanges, how to conduct a patient-centered consultation, documentation tools required for relevant pharmacist' interventions, codification of pharmacist's interventions, risks related to drug packaging and benefit risk assessment of health information technologies.These gaps represent a handicap by delaying the process that led to move from student to healthcare professional. Hospital pharmacist preceptors have to fill in these gaps before engaging students in pharmaceutical care.These results invite to revise partly the content of the academic teaching program delivered before the 5th year hospital pharmacy practice experience.
- Published
- 2015
5. Efficacy and Safety of Basiliximab as Curative Treatment of Persistent or Complicated Acute Rejection in Cardiac Transplantation
- Author
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M. Larger, P. Boissonnat, L. Sebbag, J. F. Obadia, J. Neidecker, A. Roussoulieres, and S. Bouregaa
- Subjects
Pulmonary and Respiratory Medicine ,Transplantation ,medicine.medical_specialty ,business.industry ,Basiliximab ,Curative treatment ,medicine ,Surgery ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Published
- 2014
6. II. The Etiology of Tetanus
- Author
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M. Larger
- Subjects
Pediatrics ,medicine.medical_specialty ,business.industry ,Tetanus ,Etiology ,Medicine ,Surgery ,business ,medicine.disease - Abstract
n/a
- Published
- 1887
7. Integrated clinical pharmacy activities into the pediatric kidney graft pathway
- Author
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Martin J, Jandot É, Bréant V, Sellier-Leclerc AL, Mouchoux C, Lattard C, Bacchetta J, Larger M, Dode X, and Hoegy D
- Subjects
- Humans, Child, Kidney, Kidney Transplantation methods, Pharmacy
- Abstract
The pediatric renal graft pathway is at risk of care discontinuation, even though therapeutic adherence is essential. The objective is to evaluate the integration of clinical pharmacy activities into this care pathway. This feasibility study is divided into three stages: structuring, implementing and evaluation. In pre-transplant, immediate and remote post-transplant, interviews were proposed as well as the pharmaceutical analysis of medication prescriptions. In 8 months duration, 32 patients were included. All patients included in pre-transplant and immediate post-transplant benefited from the activities. At M0, all the prescriptions analyzed resulted in at least one problem detected. Half of the transplanted patients benefited from M1 maintenance, one patient from M3 maintenance and no M6 follow-up could be carried out. This work concludes with the good feasibility and integration of clinical pharmacy activities within the care pathway.
- Published
- 2023
- Full Text
- View/download PDF
8. [Identification of knowledge deficits of pharmacy students at the beginning of the fifth year of pharmacy practice experience: Proposals to change the content of academic programs].
- Author
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Charpiat B, Derfoufi S, Larger M, Janoly-Dumenil A, Mouchoux C, Allenet B, Tod M, Grassin J, Boulieu R, Catala O, Bedouch P, Goudable J, and Vinciguerra C
- Subjects
- Adult, Educational Measurement, Female, France, Humans, Male, Pharmacists, Pharmacy Service, Hospital, Young Adult, Curriculum, Education, Pharmacy methods, Preceptorship methods, Students, Pharmacy
- Abstract
Introduction: In France, community pharmacy students performed a hospital pharmacy practice experience during the 5th year of the university curriculum. The purpose of a part of the content of the academic teaching program delivered before this practice experience is to prepare the students for their future hospital activities. It should enable them for the practical use of knowledge in order to improve pharmacotherapy, laboratory diagnosis and monitoring of patients' care. The aim of this study was to show if there are gaps in this program., Methods: Fourteen students performing their clerkship in a teaching hospital were invited to highlight these gaps when they were gradually immersed in the pharmaceutical care. They did so under the careful observation of hospital pharmacist preceptors. These practitioners referred to professional guidelines, documentary tools used in daily clinical practice and publications supporting their pharmaceutical care practices., Results: Shortcomings and gaps identified were: how to communicate with other healthcare professionals and the content of verbal exchanges, how to conduct a patient-centered consultation, documentation tools required for relevant pharmacist' interventions, codification of pharmacist's interventions, risks related to drug packaging and benefit risk assessment of health information technologies., Discussion: These gaps represent a handicap by delaying the process that led to move from student to healthcare professional. Hospital pharmacist preceptors have to fill in these gaps before engaging students in pharmaceutical care., Conclusion: These results invite to revise partly the content of the academic teaching program delivered before the 5th year hospital pharmacy practice experience., (Copyright © 2016 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF
9. Monitoring of azathioprine metabolites in pediatric patients with autoimmune hepatitis.
- Author
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Nguyen TM, Daubard M, Le Gall C, Larger M, Lachaux A, and Boulieu R
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- Adolescent, Adrenal Cortex Hormones therapeutic use, Anti-Inflammatory Agents therapeutic use, Azathioprine adverse effects, Biotransformation, Blood Cell Count, Child, Child, Preschool, Chromatography, High Pressure Liquid, Drug Monitoring, Drug Therapy, Combination, Female, Humans, Immunosuppressive Agents adverse effects, Liver Function Tests, Male, Mercaptopurine analogs & derivatives, Mercaptopurine blood, Thioguanine blood, Azathioprine pharmacokinetics, Azathioprine therapeutic use, Hepatitis, Autoimmune blood, Hepatitis, Autoimmune drug therapy, Immunosuppressive Agents pharmacokinetics, Immunosuppressive Agents therapeutic use
- Abstract
Azathioprine is commonly used in the treatment of autoimmune hepatitis (AIH). Few data are available on drug monitoring of azathioprine metabolites in patients with AIH, especially in pediatric patients. The purpose of this study was to investigate intracellular thiopurine metabolites in children with AIH and to assess the relevance of drug monitoring compared with the efficacy and toxicity. Data from 28 patients with AIH treated by azathioprine for at least 3 months were recorded. 6-Thioguanine nucleotides (6-TGN) and 6-methyl mercaptopurine nucleotides (6-MeMPN) concentrations and TPMT activity were determined by high-performance liquid chromatography. Blood cell counts and liver function tests were also collected and the clinical outcome was documented. A wide interindividual variability in 6-TGN and 6-MeMPN concentrations was observed with values ranging from 51 to 1966 pmol/8 x 10(8) red blood cells (RBCs) for 6-TGN and from 42 to 8189 pmol/8 x 10(8) RBCs for 6-MeMPN. A total of 61.4% of the patients achieved remission and only 32.6% of these children had 6-TGN values within the target range proposed for inflammatory bowel disease (250-450 pmol/8 x 10(8) red blood cells). No difference in metabolite concentrations was observed between children in remission and those with active disease. Azathioprine dosage was significantly related to 6-TGN and 6-MeMPN levels (r = 0.308, P < 0.001 and r = 0.405, P < 0.001, respectively). A significant negative correlation was observed between 6-TGN concentrations and erythrocyte and lymphocyte counts, whereas 6-MeMPN was not related to blood cell counts. Although leukocyte counts were not related to 6-TGN concentrations, patients with leucopenia exhibited higher 6-TGN values than those without leucopenia (median values 438 pmol/8 x 10(8) RBCs versus 405 pmol/8 x 10(8) RBCs, respectively). Thiopurine metabolite monitoring appears useful in identifying the myelotoxicity and the hepatotoxicity as a result of azathioprine with disease recurrence and to assess adherence to therapy. A further larger study will be required to confirm the optimal recommended target for thiopurine metabolites to achieve remission in patients with AIH.
- Published
- 2010
- Full Text
- View/download PDF
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