1. BDNF Val66Met polymorphism and brain volumes in multiple sclerosis
- Author
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Laura Marcuccio, Antonio Russo, Marco Comerci, M. L. De Bonis, Alessandro Tessitore, G. Tedeschi, D. Dinacci, Simona Bonavita, Bruno Alfano, G. Servillo, Luigi Lavorgna, O. Picconi, Rosaria Sacco, Antonio Gallo, Patrizia Galletti, Dinacci, D, Tessitore, Alessandro, Russo, Antonio, DE BONIS, Ml, Lavorgna, L, Picconi, O, Sacco, R, Bonavita, Simona, Gallo, Antonio, Servillo, G, Marcuccio, L, Comerci, M, Galletti, P, Alfano, B, and Tedeschi, Gioacchino
- Subjects
Adult ,Male ,Brain atrophy ,medicine.medical_specialty ,Multiple Sclerosis ,Neurology ,Adolescent ,Genotype ,DNA Mutational Analysis ,Dermatology ,Polymorphism, Single Nucleotide ,White matter ,Disability Evaluation ,Young Adult ,Methionine ,Atrophy ,Gene Frequency ,Internal medicine ,Image Processing, Computer-Assisted ,medicine ,Humans ,Allele ,Pathological ,Brain-derived neurotrophic factor ,Analysis of Variance ,BDNF polymorphism ,Brain-Derived Neurotrophic Factor ,Multiple sclerosis ,Brain ,Valine ,General Medicine ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Psychiatry and Mental health ,medicine.anatomical_structure ,Endocrinology ,Case-Control Studies ,Regression Analysis ,Female ,Neurology (clinical) ,Psychology ,Neuroscience ,MRI - Abstract
Brain derived neurotrophic factor (BDNF) regulates several CNS physiological and pathological processes. To investigate in multiple sclerosis (MS) patients, the relationship between the Val66Met polymorphism of BDNF and clinical markers of disease activity and MRI markers of focal and diffuse brain pathologies. 45 MS patients and 34 healthy controls (HCs) were genotyped and subjected to clinical-MRI examination. Global white matter fraction (gWM-f), gray matter-f (GM-f), cerebrospinal fluid-f (CSF-f), and abnormal WM-f were measured. We studied 26 Val/Val and 19 Val/Met patients and 23 Val/Val and 11 Val/Met HCs. We found that Val/Val patients had lower GM-f and higher CSF-f than Val/Val HCs; such differences were not statistically significant comparing Val/Met patients to HCs. The regression analysis showed that both Val/Met genotype and relapse number were associated with lower CSF-f. Our data suggest that Met allele might be a protective factor against MS as it is associated to a lower brain atrophy.
- Published
- 2010