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BDNF Val66Met polymorphism and brain volumes in multiple sclerosis
- Source :
- Neurological sciences (Testo stamp.) 32 (2011): 117–123. doi:10.1007/s10072-010-0433-z, info:cnr-pdr/source/autori:Dinacci, D.; Tessitore, A.; Russo, A.; De Bonis, M. L.; Lavorgna, L.; Picconi, O.; Sacco, R.; Bonavita, S.; Gallo, A.; Servillo, G.; Marcuccio, L.; Comerci, M.; Galletti, P.; Alfano, B.; Tedeschi, G./titolo:BDNF Val66Met polymorphism and brain volumes in multiple sclerosis/doi:10.1007%2Fs10072-010-0433-z/rivista:Neurological sciences (Testo stamp.)/anno:2011/pagina_da:117/pagina_a:123/intervallo_pagine:117–123/volume:32
- Publication Year :
- 2010
- Publisher :
- Springer Science and Business Media LLC, 2010.
-
Abstract
- Brain derived neurotrophic factor (BDNF) regulates several CNS physiological and pathological processes. To investigate in multiple sclerosis (MS) patients, the relationship between the Val66Met polymorphism of BDNF and clinical markers of disease activity and MRI markers of focal and diffuse brain pathologies. 45 MS patients and 34 healthy controls (HCs) were genotyped and subjected to clinical-MRI examination. Global white matter fraction (gWM-f), gray matter-f (GM-f), cerebrospinal fluid-f (CSF-f), and abnormal WM-f were measured. We studied 26 Val/Val and 19 Val/Met patients and 23 Val/Val and 11 Val/Met HCs. We found that Val/Val patients had lower GM-f and higher CSF-f than Val/Val HCs; such differences were not statistically significant comparing Val/Met patients to HCs. The regression analysis showed that both Val/Met genotype and relapse number were associated with lower CSF-f. Our data suggest that Met allele might be a protective factor against MS as it is associated to a lower brain atrophy.
- Subjects :
- Adult
Male
Brain atrophy
medicine.medical_specialty
Multiple Sclerosis
Neurology
Adolescent
Genotype
DNA Mutational Analysis
Dermatology
Polymorphism, Single Nucleotide
White matter
Disability Evaluation
Young Adult
Methionine
Atrophy
Gene Frequency
Internal medicine
Image Processing, Computer-Assisted
medicine
Humans
Allele
Pathological
Brain-derived neurotrophic factor
Analysis of Variance
BDNF polymorphism
Brain-Derived Neurotrophic Factor
Multiple sclerosis
Brain
Valine
General Medicine
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Psychiatry and Mental health
medicine.anatomical_structure
Endocrinology
Case-Control Studies
Regression Analysis
Female
Neurology (clinical)
Psychology
Neuroscience
MRI
Subjects
Details
- ISSN :
- 15903478 and 15901874
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Neurological Sciences
- Accession number :
- edsair.doi.dedup.....348fc803b9956d6e782c265e21eb0047