1. Can virostatic chemotherapy and/or adoptive allogeneic immunotherapy eradicate in vivo Friend's virus infection?
- Author
-
E. Chenu, C. Bourut, Mathé G, and M Trabaud
- Subjects
viruses ,medicine.medical_treatment ,Biology ,Virus ,Mice ,chemistry.chemical_compound ,Drug Therapy ,In vivo ,hemic and lymphatic diseases ,medicine ,Animals ,Pharmacology ,Elliptinium ,Chemotherapy ,Leukemia, Experimental ,General Medicine ,Immunotherapy ,Virology ,In vitro ,Drug Combinations ,chemistry ,Immunology ,HIV-1 ,Acriflavine ,Zidovudine - Abstract
While none of the three drugs which exert an in vitro anti-HIV effect, neither AZT nor the other two. acriflavine and elliptinium, which we have shown to be more efficient than AZT, is able to eradicate Friend's virus in vivo , the combination of the 3 drugs at much smaller doses than when given alone seems able to eradicate it in almost 30% of the infected animals. This possible eradicatng effect of virostatics in combination is compared with the results we had previously obtained with lymphocytes of virus-immunized allogeneic donors. Friend's virus / virostatic chemotherapy / adoptive allogeneic Immunotherapy.
- Published
- 1990
- Full Text
- View/download PDF