33 results on '"Lutter, Johanna I"'
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2. Reduced decline of lung diffusing capacity in COPD patients with diabetes and metformin treatment
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Kahnert, Kathrin, Andreas, Stefan, Kellerer, Christina, Lutter, Johanna I., Lucke, Tanja, Yildirim, Önder, Lehmann, Mareike, Seissler, Jochen, Behr, Jürgen, Frankenberger, Marion, Bals, Robert, Watz, Henrik, Welte, Tobias, Trudzinski, Franziska C., Vogelmeier, Claus F., Alter, Peter, and Jörres, Rudolf A.
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- 2022
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3. Effect of BMI on health care expenditures stratified by COPD GOLD severity grades: Results from the LQ-DMP study
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Kirsch, Florian, Schramm, Anja, Kurz, Christoph, Schwarzkopf, Larissa, Lutter, Johanna I., Huber, Manuel, and Leidl, Reiner
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- 2020
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4. Relationship between clinical and radiological signs of bronchiectasis in COPD patients: Results from COSYCONET
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Stefan, Andreas, Robert, Bals, Jürgen, Behr, Kathrin, Kahnert, Burkhard, Bewig, Bahmer, Thomas, Roland, Buhl, Ralf, Ewert, Beate, Stubbe, Joachim H, Ficker, Manfred, Gogol, Christian, Grohé, Rainer, Hauck, Matthias, Held, Berthold, Jany, Markus, Henke, Felix, Herth, Gerd, Höffken, Hugo A, Katus, Anne-Marie, Kirsten, Henrik, Watz, Rembert, Koczulla, Klaus, Kenn, Juliane, Kronsbein, Cornelia, Kropf-Sanchen, Christoph, Lange, Peter, Zabel, Michael, Pfeifer, Winfried J, Randerath, Werner, Seeger, Michael, Studnicka, Christian, Taube, Helmut, Teschler, Hartmut, Timmermann, Christian, Virchow J., Claus, Vogelmeier, Ulrich, Wagner, Tobias, Welte, Hubert, Wirtz, Lehnert, Doris, Struck, Birte, Krabbe, Lenka, Arikan, Barbara, Tobias, Julia, Spangel, Gina, Teng, Julia, Essen, Ruhrlandklinik gGmbH., Pieper, Jeanette, Gleiniger, Margret, Markworth, Britta, Hinz, Zaklina, Hundack-Winter, Petra, Burmann, Ellen, Wons, Katrin, Rieber, Ulrike, Schaufler, Beate, Seibert, Martina, Schwedler, Katrin, Michalewski, Sabine, Rohweder, Sonja, Kiel, Campus, Berger, Patricia, Schottel, Diana, Klöser, Manuel, Janke, Vivien, Untsch, Rosalie, Graf, Jana, Reichel, Anita, Weiß, Gertraud, Traugott, Erich, Ziss, Barbara, Kietzmann, Ilona, Schrade-Illmann, Michaela, Polte, Beate, Böckmann, Cornelia, Hübner, Gudrun, Sterk, Lena, Wirz, Anne, Kahnert, Kathrin, Jörres, Rudolf A., Kauczor, Hans-Ulrich, Biederer, Jürgen, Jobst, Bertram, Alter, Peter, Biertz, Frank, Mertsch, Pontus, Lucke, Tanja, Lutter, Johanna I., Trudzinski, Franziska C., Behr, Jürgen, Bals, Robert, Watz, Henrik, Vogelmeier, Claus F., and Welte, Tobias
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- 2020
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5. Utilization and determinants of use of non-pharmacological interventions in COPD: Results of the COSYCONET cohort
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Lutter, Johanna I., Lukas, Marco, Schwarzkopf, Larissa, Jörres, Rudolf A., Studnicka, Michael, Kahnert, Kathrin, Karrasch, Stefan, Bewig, Burkhard, Vogelmeier, Claus F., and Holle, Rolf
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- 2020
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6. CAT score single item analysis in patients with COPD: Results from COSYCONET
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Stefan, Andreas, Robert, Bals, Jürgen, Behr, Kathrin, Kahnert, Burkhard, Bewig, Roland, Buhl, Ralf, Ewert, Beate, Stubbe, Ficker, Joachim H., Manfred, Gogol, Christian, Grohé, Rainer, Hauck, Matthias, Held, Berthold, Jany, Markus, Henke, Felix, Herth, Gerd, Höffken, Katus Hugo, A., Anne-Marie, Kirsten, Henrik, Watz, Rembert, Koczulla, Klaus, Kenn, Juliane, Kronsbein, Cornelia, Kropf-Sanchen, Christoph, Lange, Peter, Zabel, Michael, Pfeifer, Randerath Winfried, J., Werner, Seeger, Michael, Studnicka, Christian, Taube, Helmut, Teschler, Hartmut, Timmermann, Christian, Virchow J., Claus, Vogelmeier, Ulrich, Wagner, Tobias, Welte, Hubert, Wirtz, Lehnert, Doris, Struck, Birte, Krabbe, Lenka, Arikan, Barbara, Tobias, Julia, Speth, Kornelia, Pieper, Jeanette, Gleiniger, Margret, Markworth, Britta, Hinz, Zaklina, Burmann, Ellen, Wons, Katrin, Rieber, Ulrike, Schaufler, Beate, Schwedler, Katrin, Michalewski, Sabine, Rohweder, Sonja, Berger, Patricia, Schottel, Diana, Janke, Vivien, Untsch, Rosalie, Graf, Jana, Reichel, Anita, Weiß, Gertraud, Traugott, Erich, Kietzmann, Ilona, Schrade-Illmann, Michaela, Polte, Beate, Hübner, Gudrun, Marietta von Siemens, Sarah, Alter, Peter, Lutter, Johanna I., Kauczor, Hans-Ulrich, Jobst, Bertram, Bals, Robert, Trudzinski, Franziska C., Söhler, Sandra, Behr, Jürgen, Watz, Henrik, Waschki, Benjamin, Bewig, Burkhard, Jones, Paul W., Welte, Tobias, Vogelmeier, Claus F., Jörres, Rudolf A., and Kahnert, Kathrin
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- 2019
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7. Direct and indirect costs of COPD progression and its comorbidities in a structured disease management program: results from the LQ-DMP study
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Kirsch, Florian, Schramm, Anja, Schwarzkopf, Larissa, Lutter, Johanna I., Szentes, Boglárka, Huber, Manuel, and Leidl, Reiner
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- 2019
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8. Are health risk attitude and general risk attitude associated with healthcare utilization, costs and working ability? Results from the German KORA FF4 cohort study
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Lutter, Johanna I., Szentes, Boglárka, Wacker, Margarethe E., Winter, Joachim, Wichert, Sebastian, Peters, Annette, Holle, Rolf, and Leidl, Reiner
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- 2019
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9. Impact of Education on COPD Severity and All-Cause Mortality in Lifetime Never-Smokers and Longtime Ex-Smokers : Results of the COSYCONET Cohort
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Lutter,Johanna I, Jörres,Rudolf A, Welte,Tobias, Watz,Henrik, Waschki,Benjamin, Alter,Peter, Trudzinski,Franziska C, Ohlander,Johan, Behr,Jürgen, Bals,Robert, Studnicka,Michael, Holle,Rolf, Vogelmeier,Claus F, and Kahnert,Kathrin
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socioeconomic status ,education ,never-smoker ,COPD ,International Journal of Chronic Obstructive Pulmonary Disease - Abstract
Johanna I Lutter,1 Rudolf A Jörres,2 Tobias Welte,3 Henrik Watz,4 Benjamin Waschki,5 Peter Alter,6 Franziska C Trudzinski,7 Johan Ohlander,1,8 Jürgen Behr,9 Robert Bals,10 Michael Studnicka,11 Rolf Holle,12 Claus F Vogelmeier,6 Kathrin Kahnert9 1Institute of Health Economics and Health Care Management, Helmholtz Zentrum München GmbH - German Research Center for Environmental Health, Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Munich, Germany; 2Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Comprehensive Pneumology Center Munich (CPC-M), Ludwig-Maximilians-Universität München, Munich 80336, Germany; 3Department of Pneumology, Hannover Medical School, Hannover 30625, Germany; 4Pulmonary Research Institute at Lungen Clinic Grosshansdorf, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Grosshansdorf 22927, Germany; 5Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany; 6Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-University Marburg (UMR), Germany, Member of the German Center for Lung Research (DZL), Marburg 35043, Germany; 7Department of Diagnostic & Interventional Radiology, University Hospital of Heidelberg, Heidelberg, Germany; 8Institute for Risk Assessment Sciences, Utrecht University, Utrecht 3584 CM, Netherlands; 9Department of Internal Medicine V, University of Munich (LMU), Comprehensive Pneumology Center, Member of the German Center for Lung Research (DZL), Munich, 80336, Germany; 10Department of Internal Medicine V – Pulmonology, Allergology, Respiratory Intensive Care Medicine, Saarland University Hospital, Homburg 66424, Germany; 11Department of Pneumology, Paracelsus Medical University Salzburg, Universitätsklinikum Salzburg, Salzburg 5020, Austria; 12Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Ludwig-Maximilians-University Munich (LMU), Munich 81377, GermanyCorrespondence: Kathrin KahnertDepartment of Internal Medicine V, University of Munich (LMU), Comprehensive Pneumology Center, Member of the German Center for Lung Research (DZL), Ziemssenstr. 1, Munich 80336, GermanyEmail Kathrin.Kahnert@med.uni-muenchen.deBackground: Beyond smoking, several risk factors for the development of chronic obstructive pulmonary disease (COPD) have been described, among which socioeconomic status including education is of particular interest. We studied the contribution of education to lung function and symptoms relative to smoking in a group of never-smokers with COPD compared to a group of long-time ex-smokers with COPD.Methods: We used baseline data of the COSYCONET cohort, including patients of GOLD grades 1– 4 who were either never-smokers (n=150, age 68.5y, 53.3% female) or ex-smokers (≥ 10 packyears) for at least 10 years (n=616, 68.3y, 29.9% female). Socioeconomic status was analyzed using education level and mortality was assessed over a follow-up period of 4.5 years. Analyses were performed using ANOVA and regression models.Results: Spirometric lung function did not differ between groups, whereas CO diffusing capacity and indicators of lung hyperinflation/air-trapping showed better values in the never-smoker group. In both groups, spirometric lung function depended on the education level, with better values for higher education. Quality of life and 6-MWD were significantly different in never-smokers as well as patients with higher education. Asthma, alpha-1-antitrypsin deficiency, and bronchiectasis were more often reported in never-smokers, and asthma was more often reported in patients with higher education. Higher education was also associated with reduced mortality (hazard ratio 0.46; 95% CI 0.22– 0.98).Conclusion: Overall, in the COSYCONET COPD cohort, differences in functional status between never-smokers and long-time ex-smokers were not large. Compared to that, the dependence on education level was more prominent, with higher education associated with better outcomes, including mortality. These data indicate that non-smoking COPD patients’ socioeconomic factors are relevant and should be taken into account by clinicians.Keywords: COPD, never-smoker, education, socioeconomic status
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- 2022
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10. The association of cognitive functioning as measured by the DemTect with functional and clinical characteristics of COPD: results from the COSYCONET cohort
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von Siemens, Sarah Marietta, Perneczky, Robert, Waschki, Benjamin, Lutter, Johanna I, Welte, Tobias, Jörres, Rudolf A, Kahnert, Kathrin, group, COSYCONET study, Andreas, Stefan, Bals, Robert, Behr, Jürgen, Vogelmeier, Claus F, Bewig, Burkhard, Buhl, Roland, Ewert, Ralf, Stubbe, Beate, Gogol, Manfred, Grohé, Christian, Hauck, Rainer, Held, Matthias, Jany, Berthold, Henke, Markus, Herth, Felix, Höffken, Gerd, Katus, Hugo A, Kirsten, Anne-Marie, Watz, Henrik, Koczulla, Rembert, Kenn, Klaus, Kronsbein, Juliane, Kropf-Sanchen, Cornelia, Lange, Christoph, Kauffmann-Guerrero, Diego, Zabel, Peter, Pfeifer, Michael, Randerath, Winfried J, Seeger, Werner, Studnicka, Michael, Taube, Christian, Teschler, Helmut, Timmermann, Hartmut, Virchow, J Christian, Vogelmeier, Claus, Alter, Peter, Wagner, Ulrich, Wirtz, Hubert, Trudzinski, Franziska C, and Söhler, Sandra
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Male ,medicine.medical_specialty ,epidemiology [Cognitive Dysfunction] ,psychology [Pulmonary Disease, Chronic Obstructive] ,Medizin ,Comorbidity ,Cohort Studies ,03 medical and health sciences ,FEV1/FVC ratio ,Pulmonary Disease, Chronic Obstructive ,0302 clinical medicine ,Cognition ,epidemiology [Pulmonary Disease, Chronic Obstructive] ,Surveys and Questionnaires ,medicine ,Dementia ,Humans ,COPD ,Cognitive Dysfunction ,ddc:610 ,Cognitive skill ,Path analysis (statistics) ,Aged ,lcsh:RC705-779 ,business.industry ,Research ,physiology [Cognition] ,diagnosis [Pulmonary Disease, Chronic Obstructive] ,lcsh:Diseases of the respiratory system ,Middle Aged ,medicine.disease ,Mental Status and Dementia Tests ,humanities ,Cross-Sectional Studies ,Cognitive impairment ,diagnosis [Cognitive Dysfunction] ,030228 respiratory system ,Cohort ,Physical therapy ,Female ,psychology [Cognitive Dysfunction] ,business ,030217 neurology & neurosurgery ,Cognitive load - Abstract
Alterations of cognitive functions have been described in COPD. Our study aimed to disentangle the relationship between the degree of cognitive function and COPD characteristics including quality of life (QoL).Data from 1969 COPD patients of the COSYCONET cohort (GOLD grades 1–4; 1216 male/ 753 female; mean (SD) age 64.9 ± 8.4 years) were analysed using regression and path analysis. The DemTect screening tool was used to measure cognitive function, and the St. George‘s respiratory questionnaire (SGRQ) to assess disease-specific QoL.DemTect scores were =60 years of age. For statistical reasons, we used the average of both algorithms independent of age in all subsequent analyses. The DemTect scores were associated with oxygen content, 6-min-walking distance (6-MWD), C-reactive protein (CRP), modified Medical Research Council dyspnoea scale (mMRC) and the SGRQ impact score. Conversely, the SGRQ impact score was independently associated with 6-MWD, FVC, mMRC and DemTect. These results were combined into a path analysis model to account for direct and indirect effects. The DemTect score had a small, but independent impact on QoL, irrespective of the inclusion of COPD-specific influencing factors or a diagnosis of cognitive impairment.We conclude that in patients with stable COPD lower oxygen content of blood as a measure of peripheral oxygen supply, lower exercise capacity in terms of 6-MWD, and higher CRP levels were associated with reduced cognitive capacity. Furthermore, a reduction in cognitive capacity was associated with reduced disease-specific quality of life. As a potential clinical implication of this work, we suggest to screen especially patients with low oxygen content and low 6-MWD for cognitive impairment.
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- 2022
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11. Relationship between clinical and radiological signs of bronchiectasis in COPD patients: Results from COSYCONET
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Kahnert, Kathrin, Jörres, Rudolf A., Kauczor, Hans-Ulrich, Biederer, Jürgen, Jobst, Bertram, Alter, Peter, Biertz, Frank, Mertsch, Pontus, Lucke, Tanja, Lutter, Johanna I., Trudzinski, Franziska C., Behr, Jürgen, Bals, Robert, Watz, Henrik, Vogelmeier, Claus F., and Welte, Tobias
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CT scan ,Symptoms ,COPD ,Lung function ,Bronchiectasis - Published
- 2022
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12. Impact of Lung Function and Exacerbations on Health-Related Quality of Life in COPD Patients Within One Year: Real-World Analysis Based on Claims Data
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Stöber, Alisa, primary, Lutter, Johanna I, additional, Schwarzkopf, Larissa, additional, Kirsch, Florian, additional, Schramm, Anja, additional, Vogelmeier, Claus F, additional, and Leidl, Reiner, additional
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- 2021
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13. Gender-specific differences in COPD symptoms and their impact for the diagnosis of cardiac comorbidities
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Trudzinski, Franziska C., primary, Kellerer, Christina, additional, Jörres, Rudolf A., additional, Alter, Peter, additional, Lutter, Johanna I., additional, Trinkmann, Frederik, additional, Herth, Felix J. F., additional, Frankenberger, Marion, additional, Watz, Henrik, additional, Vogelmeier, Claus F., additional, Kauczor, Hans-Ulrich, additional, Welte, Tobias, additional, Behr, Jürgen, additional, Bals, Robert, additional, and Kahnert, Kathrin, additional
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- 2021
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14. Impact of the COVID-19 pandemic on the behaviour and health status of patients with COPD: results from the German COPD cohort COSYCONET
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Kahnert, Kathrin, primary, Lutter, Johanna I., additional, Welte, Tobias, additional, Alter, Peter, additional, Behr, Jürgen, additional, Herth, Felix, additional, Kauczor, Hans-Ulrich, additional, Söhler, Sandra, additional, Pfeifer, Michael, additional, Watz, Henrik, additional, Vogelmeier, Claus F., additional, Bals, Robert, additional, Jörres, Rudolf A., additional, and Trudzinski, Franziska C., additional
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- 2021
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15. Impact of Lung Function and Exacerbations on Health-Related Quality of Life in COPD Patients Within One Year: Real-World Analysis Based on Claims Data
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Stöber,Alisa, Lutter,Johanna I, Schwarzkopf,Larissa, Kirsch,Florian, Schramm,Anja, Vogelmeier,Claus F, Leidl,Reiner, Stöber,Alisa, Lutter,Johanna I, Schwarzkopf,Larissa, Kirsch,Florian, Schramm,Anja, Vogelmeier,Claus F, and Leidl,Reiner
- Abstract
Alisa Stöber,1,2 Johanna I Lutter,1,3 Larissa Schwarzkopf,1,3,4 Florian Kirsch,1 Anja Schramm,5 Claus F Vogelmeier,6 Reiner Leidl1,7 1Institute of Health Economics and Health Care Management, Helmholtz Zentrum München, Neuherberg, Germany; 2Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), Ludwig-Maximilians-University Munich (LMU), Munich, Germany; 3Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL), Munich, Germany; 4Institute fuer Therapieforschung (IFT), Working Group Therapy and Health Services Research, Munich, Germany; 5AOK Bayern, Service Center of Health Care Management, Regensburg, Germany; 6Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-University Marburg, Member of the German Center for Lung Research (DZL), Marburg, Germany; 7Munich Center of Health Sciences (MC-Health), Institute for Health Economics and Management, Ludwig-Maximilians-University Munich (LMU), Munich, GermanyCorrespondence: Alisa StöberInstitute of Health Economics and Health Care Management, Helmholtz Zentrum München, Neuherberg, 85764, GermanyTel +49 89 3187/43572Email alisa.stoeber@helmholtz-muenchen.dePurpose: Real-world evidence on the impact of forced expiratory volume in one second (FEV1) and exacerbations on health-related quality of life (HRQoL) in patients with chronic obstructive pulmonary disease (COPD) is sparse especially with regard to GOLD ABCD groups. This study investigates how changes in FEV1 and exacerbations affect generic and disease-specific HRQoL in COPD patients over one year.Methods: Using German claims data and survey data, we classified 3016 COPD patients and analyzed their health status by GOLD groups AB and CD. HRQoL was measured with the disease-specific COPD assessment test (CAT) and the visual analog scale (VAS) from the generic Euro-Qol 5D-5L. We applied change score models to assess associations betwee
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- 2021
16. Treatment of COPD Groups GOLD A and B with Inhaled Corticosteroids in the COSYCONET Cohort – Determinants and Consequences
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Lutter,Johanna I, Jörres,Rudolf A, Trudzinski,Franziska C, Alter,Peter, Kellerer,Christina, Watz,Henrik, Welte,Tobias, Bals,Robert, Kauffmann-Guerrero,Diego, Behr,Jürgen, Holle,Rolf, Vogelmeier,Claus F, Kahnert,Kathrin, Lutter,Johanna I, Jörres,Rudolf A, Trudzinski,Franziska C, Alter,Peter, Kellerer,Christina, Watz,Henrik, Welte,Tobias, Bals,Robert, Kauffmann-Guerrero,Diego, Behr,Jürgen, Holle,Rolf, Vogelmeier,Claus F, and Kahnert,Kathrin
- Abstract
Johanna I Lutter,1 Rudolf A Jörres,2 Franziska C Trudzinski,3 Peter Alter,4 Christina Kellerer,2,5 Henrik Watz,6 Tobias Welte,7 Robert Bals,8 Diego Kauffmann-Guerrero,9 Jürgen Behr,9 Rolf Holle,10 Claus F Vogelmeier,4 Kathrin Kahnert9 On behalf of the COSYCONET study group1Institute of Health Economics and Health Care Management, Helmholtz Zentrum München GmbH – German Research Center for Environmental Health, Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Munich, Germany; 2Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, LMU Hospital, Comprehensive Pneumology Center Munich (CPC-M), Munich, Germany; 3Department of Pneumology and Critical Care Medicine, Thoraxklinik University of Heidelberg, Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg, Germany; 4Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-University Marburg (UMR), Germany, Member of the German Center for Lung Research (DZL), Marburg, Germany; 5School of Medicine, Institute of General Practice and Health Services Research, Technical University of Munich (TUM), Munich, Germany; 6Pulmonary Research Institute at LungenClinic Grosshansdorf, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Grosshansdorf, Germany; 7Department of Pneumology, Hannover Medical School, Hannover, Germany; 8Department of Internal Medicine V – Pulmonology, Allergology, Respiratory Intensive Care Medicine, Saarland University Hospital, Homburg, Germany; 9Department of Medicine V, University of Munich (LMU), Comprehensive Pneumology Center, Member of the German Center for Lung Research (DZL), Munich, Germany; 10Institute for Medical Informatics, Biometry and Epidemiology, LMU Hospital, Munich, GermanyCorrespondence: Kathrin KahnertDe
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- 2021
17. Treatment of COPD Groups GOLD A and B with Inhaled Corticosteroids in the COSYCONET Cohort – Determinants and Consequences
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Lutter, Johanna I, primary, Jörres, Rudolf A, additional, Trudzinski, Franziska C, additional, Alter, Peter, additional, Kellerer, Christina, additional, Watz, Henrik, additional, Welte, Tobias, additional, Bals, Robert, additional, Kauffmann-Guerrero, Diego, additional, Behr, Jürgen, additional, Holle, Rolf, additional, Vogelmeier, Claus F, additional, and Kahnert, Kathrin, additional
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- 2021
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18. Additional file 3 of Health-related quality of life associates with change in FEV1 in COPD: results from the COSYCONET cohort
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Lutter, Johanna I., Jörres, Rudolf A., Kahnert, Kathrin, Schwarzkopf, Larissa, Studnicka, Michael, Karrasch, Stefan, Schulz, Holger, Vogelmeier, Claus F., and Holle, Rolf
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human activities ,humanities ,respiratory tract diseases - Abstract
Additional file 3. Table A3 Inverse Probability Weighting: Cross-sectional and longitudinal estimates for the association between FEV1 and disease-specific HRQL as measured with the SGRQ.
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- 2020
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19. Additional file 2 of Health-related quality of life associates with change in FEV1 in COPD: results from the COSYCONET cohort
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Lutter, Johanna I., Jörres, Rudolf A., Kahnert, Kathrin, Schwarzkopf, Larissa, Studnicka, Michael, Karrasch, Stefan, Schulz, Holger, Vogelmeier, Claus F., and Holle, Rolf
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sense organs ,skin and connective tissue diseases ,human activities ,humanities - Abstract
Additional file 2. Inverse Probability Weighting: Absolute adjusted mean change in SGRQ (a) and EQ VAS (b) after 36 months
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- 2020
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20. Additional file 1 of Health-related quality of life associates with change in FEV1 in COPD: results from the COSYCONET cohort
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Lutter, Johanna I., Jörres, Rudolf A., Kahnert, Kathrin, Schwarzkopf, Larissa, Studnicka, Michael, Karrasch, Stefan, Schulz, Holger, Vogelmeier, Claus F., and Holle, Rolf
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sense organs - Abstract
Additional file 1. Table A1 Baseline characteristics of COPD patients who completed the 36-month follow-up and Table A2 Clinically important change in HRQL after 36-month.
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- 2020
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21. Impact of Education on COPD Severity and All-Cause Mortality in Lifetime Never-Smokers and Longtime Ex-Smokers: Results of the COSYCONET Cohort
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Lutter,Johanna I, Jörres,Rudolf A, Welte,Tobias, Watz,Henrik, Waschki,Benjamin, Alter,Peter, Trudzinski,Franziska C, Ohlander,Johan, Behr,Jürgen, Bals,Robert, Studnicka,Michael, Holle,Rolf, Vogelmeier,Claus F, Kahnert,Kathrin, Lutter,Johanna I, Jörres,Rudolf A, Welte,Tobias, Watz,Henrik, Waschki,Benjamin, Alter,Peter, Trudzinski,Franziska C, Ohlander,Johan, Behr,Jürgen, Bals,Robert, Studnicka,Michael, Holle,Rolf, Vogelmeier,Claus F, and Kahnert,Kathrin
- Abstract
Johanna I Lutter,1 Rudolf A Jörres,2 Tobias Welte,3 Henrik Watz,4 Benjamin Waschki,5 Peter Alter,6 Franziska C Trudzinski,7 Johan Ohlander,1,8 Jürgen Behr,9 Robert Bals,10 Michael Studnicka,11 Rolf Holle,12 Claus F Vogelmeier,6 Kathrin Kahnert9 1Institute of Health Economics and Health Care Management, Helmholtz Zentrum München GmbH - German Research Center for Environmental Health, Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Munich, Germany; 2Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Comprehensive Pneumology Center Munich (CPC-M), Ludwig-Maximilians-Universität München, Munich 80336, Germany; 3Department of Pneumology, Hannover Medical School, Hannover 30625, Germany; 4Pulmonary Research Institute at Lungen Clinic Grosshansdorf, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Grosshansdorf 22927, Germany; 5Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany; 6Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-University Marburg (UMR), Germany, Member of the German Center for Lung Research (DZL), Marburg 35043, Germany; 7Department of Diagnostic & Interventional Radiology, University Hospital of Heidelberg, Heidelberg, Germany; 8Institute for Risk Assessment Sciences, Utrecht University, Utrecht 3584 CM, Netherlands; 9Department of Internal Medicine V, University of Munich (LMU), Comprehensive Pneumology Center, Member of the German Center for Lung Research (DZL), Munich, 80336, Germany; 10Department of Internal Medicine V – Pulmonology, Allergology, Respiratory Intensive Care Medicine, Saarland University Hospital, Homburg 66424, Germany; 11Department of Pneumology, Paracelsus Medical University Salzburg, Universitätsklinikum Salzburg, Salzburg
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- 2020
22. Deterioration and Mortality Risk of COPD Patients Not Fitting into Standard GOLD Categories: Results of the COSYCONET Cohort
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Mayerhofer, Barbara, primary, Jörres, Rudolf A., additional, Lutter, Johanna I., additional, Waschki, Benjamin, additional, Kauffmann-Guerrero, Diego, additional, Alter, Peter, additional, Trudzinski, Franziska Christina, additional, Herth, Felix J.F., additional, Holle, Rolf, additional, Behr, Jürgen, additional, Bals, Robert, additional, Welte, Tobias, additional, Watz, Henrik, additional, Vogelmeier, Claus F., additional, and Kahnert, Kathrin, additional
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- 2021
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23. Impact of Education on COPD Severity and All-Cause Mortality in Lifetime Never-Smokers and Longtime Ex-Smokers: Results of the COSYCONET Cohort
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Lutter, Johanna I, primary, Jörres, Rudolf A, additional, Welte, Tobias, additional, Watz, Henrik, additional, Waschki, Benjamin, additional, Alter, Peter, additional, Trudzinski, Franziska C, additional, Ohlander, Johan, additional, Behr, Jürgen, additional, Bals, Robert, additional, Studnicka, Michael, additional, Holle, Rolf, additional, Vogelmeier, Claus F, additional, and Kahnert, Kathrin, additional
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- 2020
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24. Relationship between clinical and radiological signs of bronchiectasis in COPD patients: Results from COSYCONET
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Kahnert, Kathrin, primary, Jörres, Rudolf A., additional, Kauczor, Hans-Ulrich, additional, Biederer, Jürgen, additional, Jobst, Bertram, additional, Alter, Peter, additional, Biertz, Frank, additional, Mertsch, Pontus, additional, Lucke, Tanja, additional, Lutter, Johanna I., additional, Trudzinski, Franziska C., additional, Behr, Jürgen, additional, Bals, Robert, additional, Watz, Henrik, additional, Vogelmeier, Claus F., additional, Welte, Tobias, additional, Stefan, Andreas, additional, Robert, Bals, additional, Jürgen, Behr, additional, Kathrin, Kahnert, additional, Burkhard, Bewig, additional, Bahmer, Thomas, additional, Roland, Buhl, additional, Ralf, Ewert, additional, Beate, Stubbe, additional, Joachim H, Ficker, additional, Manfred, Gogol, additional, Christian, Grohé, additional, Rainer, Hauck, additional, Matthias, Held, additional, Berthold, Jany, additional, Markus, Henke, additional, Felix, Herth, additional, Gerd, Höffken, additional, Hugo A, Katus, additional, Anne-Marie, Kirsten, additional, Henrik, Watz, additional, Rembert, Koczulla, additional, Klaus, Kenn, additional, Juliane, Kronsbein, additional, Cornelia, Kropf-Sanchen, additional, Christoph, Lange, additional, Peter, Zabel, additional, Michael, Pfeifer, additional, Winfried J, Randerath, additional, Werner, Seeger, additional, Michael, Studnicka, additional, Christian, Taube, additional, Helmut, Teschler, additional, Hartmut, Timmermann, additional, Christian, Virchow J., additional, Claus, Vogelmeier, additional, Ulrich, Wagner, additional, Tobias, Welte, additional, Hubert, Wirtz, additional, Lehnert, Doris, additional, Struck, Birte, additional, Krabbe, Lenka, additional, Arikan, Barbara, additional, Tobias, Julia, additional, Spangel, Gina, additional, Teng, Julia, additional, Essen, Ruhrlandklinik gGmbH., additional, Pieper, Jeanette, additional, Gleiniger, Margret, additional, Markworth, Britta, additional, Hinz, Zaklina, additional, Hundack-Winter, Petra, additional, Burmann, Ellen, additional, Wons, Katrin, additional, Rieber, Ulrike, additional, Schaufler, Beate, additional, Seibert, Martina, additional, Schwedler, Katrin, additional, Michalewski, Sabine, additional, Rohweder, Sonja, additional, Kiel, Campus, additional, Berger, Patricia, additional, Schottel, Diana, additional, Klöser, Manuel, additional, Janke, Vivien, additional, Untsch, Rosalie, additional, Graf, Jana, additional, Reichel, Anita, additional, Weiß, Gertraud, additional, Traugott, Erich, additional, Ziss, Barbara, additional, Kietzmann, Ilona, additional, Schrade-Illmann, Michaela, additional, Polte, Beate, additional, Böckmann, Cornelia, additional, Hübner, Gudrun, additional, Sterk, Lena, additional, and Wirz, Anne, additional
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- 2020
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25. CAT score single item analysis in patients with COPD: Results from COSYCONET
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Marietta von Siemens, Sarah, primary, Alter, Peter, additional, Lutter, Johanna I., additional, Kauczor, Hans-Ulrich, additional, Jobst, Bertram, additional, Bals, Robert, additional, Trudzinski, Franziska C., additional, Söhler, Sandra, additional, Behr, Jürgen, additional, Watz, Henrik, additional, Waschki, Benjamin, additional, Bewig, Burkhard, additional, Jones, Paul W., additional, Welte, Tobias, additional, Vogelmeier, Claus F., additional, Jörres, Rudolf A., additional, Kahnert, Kathrin, additional, Stefan, Andreas, additional, Robert, Bals, additional, Jürgen, Behr, additional, Kathrin, Kahnert, additional, Burkhard, Bewig, additional, Roland, Buhl, additional, Ralf, Ewert, additional, Beate, Stubbe, additional, Ficker, Joachim H., additional, Manfred, Gogol, additional, Christian, Grohé, additional, Rainer, Hauck, additional, Matthias, Held, additional, Berthold, Jany, additional, Markus, Henke, additional, Felix, Herth, additional, Gerd, Höffken, additional, Katus Hugo, A., additional, Anne-Marie, Kirsten, additional, Henrik, Watz, additional, Rembert, Koczulla, additional, Klaus, Kenn, additional, Juliane, Kronsbein, additional, Cornelia, Kropf-Sanchen, additional, Christoph, Lange, additional, Peter, Zabel, additional, Michael, Pfeifer, additional, Randerath Winfried, J., additional, Werner, Seeger, additional, Michael, Studnicka, additional, Christian, Taube, additional, Helmut, Teschler, additional, Hartmut, Timmermann, additional, Christian, Virchow J., additional, Claus, Vogelmeier, additional, Ulrich, Wagner, additional, Tobias, Welte, additional, Hubert, Wirtz, additional, Lehnert, Doris, additional, Struck, Birte, additional, Krabbe, Lenka, additional, Arikan, Barbara, additional, Tobias, Julia, additional, Speth, Kornelia, additional, Pieper, Jeanette, additional, Gleiniger, Margret, additional, Markworth, Britta, additional, Hinz, Zaklina, additional, Burmann, Ellen, additional, Wons, Katrin, additional, Rieber, Ulrike, additional, Schaufler, Beate, additional, Schwedler, Katrin, additional, Michalewski, Sabine, additional, Rohweder, Sonja, additional, Berger, Patricia, additional, Schottel, Diana, additional, Janke, Vivien, additional, Untsch, Rosalie, additional, Graf, Jana, additional, Reichel, Anita, additional, Weiß, Gertraud, additional, Traugott, Erich, additional, Kietzmann, Ilona, additional, Schrade-Illmann, Michaela, additional, Polte, Beate, additional, and Hübner, Gudrun, additional
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- 2019
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- View/download PDF
26. Adherence to respiratory and non-respiratory medication in patients with COPD: Results of the German COSYCONET cohort
- Author
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Königsdorfer, Norbert, Jörres, Rudolf A., Söhler, Sandra, Welte, Tobias, Behr, Jürgen, Ficker, Joachim H., Bals, Robert, Watz, Henrik, Lutter, Johanna I., Lucke, Tanja, Biertz, Frank, Alter, Peter, Vogelmeier, Claus F., and Kahnert, Kathrin
- Subjects
lcsh:R5-920 ,respiratory medication ,Patient Preference and Adherence ,COPD ,treatment adherence ,lcsh:Medicine (General) ,non-respiratory medication ,nonrespiratory medication ,Copd ,Nonrespiratory Medication ,Respiratory Medication ,Treatment Adherence - Abstract
Norbert Königsdorfer,1 Rudolf A Jörres,1 Sandra Söhler,2 Tobias Welte,3 Jürgen Behr,4 Joachim H Ficker,5 Robert Bals,6 Henrik Watz,7 Johanna I Lutter,8 Tanja Lucke,1 Frank Biertz,9 Peter Alter,10 Claus F Vogelmeier,10 Kathrin Kahnert4 1Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Comprehensive Pneumology Center Munich (CPC-M), Ludwig-Maximilians-Universität München, Munich 80336, Germany; 2ASCONET Study Coordination Office, University of Marburg, Marburg 35043, Germany; 3Department of Pneumology, Hannover Medical School, Hannover 30625, Germany; 4Department of Internal Medicine V, University of Munich, Comprehensive Pneumology Center, Member of the German Center for Lung Research, Munich 80336, Germany; 5Department of Respiratory Medicine, Allergology and Sleep Medicine, General Hospital Nuernberg, Paracelsus Medical University, Nuernberg, Germany; 6Department of Internal Medicine V, Pneumology, Allergology, Respiratory Intensive Care Medicine, Saarland University Hospital, Homburg 66424, Germany; 7Pulmonary Research Institute at LungenClinic Grosshansdorf, Airway Research Center North, Member of the German Center for Lung Research, Grosshansdorf 22927, Germany; 8Institute of Health Economics and Health Care Management, Helmholtz Zentrum München GmbH – German Research Center for Environmental Health, Comprehensive Pneumology Center Munich (CPC-M), Munich 85764, Germany; 9Institute for Biostatistics, Hannover Medical School, Hannover 30625, Germany; 10Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-University Marburg, Marburg 35043, GermanyCorrespondence: Kathrin KahnertDepartment of Internal Medicine V, University of Munich, Comprehensive Pneumology Center, Member of the German Center for Lung Research, Ziemssenstr. 1, Munich 80336, GermanyTel +49 89 4400 2590Email Kathrin.Kahnert@med.uni-muenchen.deBackground: Adherence to COPD medication is often considered to be lower than in other chronic diseases. In view of the frequent comorbidities of COPD, the economic impact of nonadherence and the potential for adverse effects, a direct comparison between the adherence to respiratory and nonrespiratory medication in the same patients seems of particular interest.Objectives: We aimed to investigate the intake of respiratory and nonrespiratory medication in the same patients with COPD and frequent comorbidities.Method: Within the COPD cohort COSYCONET, we contacted 1042 patients, mailing them a list with all medication regarding all their diseases, asking for regular, irregular and non-intake.Results: Valid responses were obtained in 707 patients covering a wide spectrum of drugs. Intake of LABA, LAMA or ICS was regular in 91.9% of patients, even higher for cardiovascular and antidiabetes medication but lower for hyperlipidemia and depression/anxiety medication. Regular intake of respiratory medication did not depend on GOLD groups A-D or grades 1–4, was highest in patients with concomitant cardiovascular disorders and was lowest for concomitant asthma. It was slightly larger for LAMA and LABA administered via combined compared to single inhalers, and lower when similar compounds were prescribed twice. Most differences did not reach statistical significance owing to the overall high adherence.Conclusion: Our results indicate a high adherence to respiratory medication in participants of a COPD cohort, especially in those with cardiovascular comorbidities. Compared to the lower adherence reported in the literature for COPD patients, our observations still suggest some room for improvement, possibly through disease management programs.Keywords: COPD, treatment adherence, respiratory medication, nonrespiratory medication
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- 2019
27. Adherence To Respiratory And Nonrespiratory Medication In Patients With COPD: Results Of The German COSYCONET Cohort
- Author
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Königsdorfer,Norbert, Jörres,Rudolf A, Söhler,Sandra, Welte,Tobias, Behr,Jürgen, Ficker,Joachim H, Bals,Robert, Watz,Henrik, Lutter,Johanna I, Lucke,Tanja, Biertz,Frank, Alter,Peter, Vogelmeier,Claus F, Kahnert,Kathrin, Königsdorfer,Norbert, Jörres,Rudolf A, Söhler,Sandra, Welte,Tobias, Behr,Jürgen, Ficker,Joachim H, Bals,Robert, Watz,Henrik, Lutter,Johanna I, Lucke,Tanja, Biertz,Frank, Alter,Peter, Vogelmeier,Claus F, and Kahnert,Kathrin
- Abstract
Norbert Königsdorfer,1 Rudolf A Jörres,1 Sandra Söhler,2 Tobias Welte,3 Jürgen Behr,4 Joachim H Ficker,5 Robert Bals,6 Henrik Watz,7 Johanna I Lutter,8 Tanja Lucke,1 Frank Biertz,9 Peter Alter,10 Claus F Vogelmeier,10 Kathrin Kahnert4 1Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Comprehensive Pneumology Center Munich (CPC-M), Ludwig-Maximilians-Universität München, Munich 80336, Germany; 2ASCONET Study Coordination Office, University of Marburg, Marburg 35043, Germany; 3Department of Pneumology, Hannover Medical School, Hannover 30625, Germany; 4Department of Internal Medicine V, University of Munich, Comprehensive Pneumology Center, Member of the German Center for Lung Research, Munich 80336, Germany; 5Department of Respiratory Medicine, Allergology and Sleep Medicine, General Hospital Nuernberg, Paracelsus Medical University, Nuernberg, Germany; 6Department of Internal Medicine V, Pneumology, Allergology, Respiratory Intensive Care Medicine, Saarland University Hospital, Homburg 66424, Germany; 7Pulmonary Research Institute at LungenClinic Grosshansdorf, Airway Research Center North, Member of the German Center for Lung Research, Grosshansdorf 22927, Germany; 8Institute of Health Economics and Health Care Management, Helmholtz Zentrum München GmbH – German Research Center for Environmental Health, Comprehensive Pneumology Center Munich (CPC-M), Munich 85764, Germany; 9Institute for Biostatistics, Hannover Medical School, Hannover 30625, Germany; 10Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-University Marburg, Marburg 35043, GermanyCorrespondence: Kathrin KahnertDepartment of Internal Medicine V, University of Munich, Comprehensive Pneumology Center, Member of the German Center for Lung Research, Ziemssenstr. 1, Munich 80336, GermanyTel +49 89 4400 2590Email Kathrin.Kahnert@med.u
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- 2019
28. Determinants of healthcare utilization and costs in COPD patients: first longitudinal results from the German COPD cohort COSYCONET
- Author
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Byng,Danalyn, Lutter,Johanna I, Wacker,Margarethe E, Jörres,Rudolf A, Liu,Xiaofei, Karrasch,Stefan, Schulz,Holger, Vogelmeier,Claus F., Holle,Rolf, Byng,Danalyn, Lutter,Johanna I, Wacker,Margarethe E, Jörres,Rudolf A, Liu,Xiaofei, Karrasch,Stefan, Schulz,Holger, Vogelmeier,Claus F., and Holle,Rolf
- Abstract
Danalyn Byng,*,1,2 Johanna I Lutter*,1, Margarethe E Wacker,1 Rudolf A Jörres,3 Xiaofei Liu,4 Stefan Karrasch3,5, Holger Schulz,5 Claus Vogelmeier,6 Rolf Holle1, On behalf of the COSYCONET Consortium1Institute of Health Economics and Health Care Management, Helmholtz Zentrum München, GmbH – German Research Center for Environmental Health, Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, 85764 Neuherberg, Germany; 2Institute for Medical Informatics, Biometry and Epidemiology (IBE), Ludwig-Maximilians-University Munich (LMU), 81377 Munich, Germany; 3Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, 80336 Munich, Germany; 4Institute for Biostatistics, Hannover Medical School, 30625 Hannover, Germany; 5Institute of Epidemiology, Helmholtz Zentrum München (GmbH) – German Research Center for Environmental Health, Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL), 85764 Neuherberg, Germany; 6Department of Respiratory Medicine, University of Marburg, University Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research, 35043 Marburg, Germany*These authors contributed equally to this workBackground: In light of overall increasing healthcare expenditures, it is mandatory to study determinants of future costs in chronic diseases. This study reports the first longitudinal results on healthcare utilization and associated costs from the German chronic obstructive pulmonary disease (COPD) cohort COSYCONET.Material and methods: Based on self-reported data of 1904 patients with COPD who attended the baseline and 18-month follow-up visits, direct costs were calculated for the 12 months preceding both examinations. Direct costs at follow-up were regressed on baseline disease severity and other co-variables to identify determinants of future
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- 2019
29. Adherence To Respiratory And Nonrespiratory Medication In Patients With COPD: Results Of The German COSYCONET Cohort
- Author
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Königsdorfer, Norbert, primary, Jörres, Rudolf A, additional, Söhler, Sandra, additional, Welte, Tobias, additional, Behr, Jürgen, additional, Ficker, Joachim H, additional, Bals, Robert, additional, Watz, Henrik, additional, Lutter, Johanna I, additional, Lucke, Tanja, additional, Biertz, Frank, additional, Alter, Peter, additional, Vogelmeier, Claus F, additional, and Kahnert, Kathrin, additional
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- 2019
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30. Determinants of healthcare utilization and costs in COPD patients: first longitudinal results from the German COPD cohort COSYCONET
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Byng, Danalyn, primary, Lutter, Johanna I, additional, Wacker, Margarethe E, additional, Jörres, Rudolf A, additional, Liu, Xiaofei, additional, Karrasch, Stefan, additional, Schulz, Holger, additional, Vogelmeier, Claus F., additional, and Holle, Rolf, additional
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- 2019
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31. Health-related quality of life associates with change in FEV1 in COPD: results from the COSYCONET cohort.
- Author
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Lutter, Johanna I., Jörres, Rudolf A., Kahnert, Kathrin, Schwarzkopf, Larissa, Studnicka, Michael, Karrasch, Stefan, Schulz, Holger, Vogelmeier, Claus F., Holle, Rolf, for the COSYCONET Study Group, Andreas, Stefan, Bals, Robert, Behr, Jürgen, Bewig, Burkhard, Buhl, Roland, Ewert, Ralf, Stubbe, Beate, Ficker, Joachim H., Gogol, Manfred, and Grohé, Christian
- Subjects
OBSTRUCTIVE lung diseases ,QUALITY of life ,VISUAL analog scale - Abstract
Background: Forced expiratory volume in one second (FEV1) characterizes the pathophysiology of COPD and different trajectories of FEV1 decline have been observed in patients with COPD (e.g. gradual or episodic). There is limited information about the development of patient-reported health-related quality of life (HRQL) over the full range of the natural history of COPD. We examined the longitudinal association between change in FEV1 and change in disease-specific and generic HRQL.Methods: We analysed data of 1734 patients with COPD participating in the COSYCONET cohort with up to 3 years of follow-up. Patients completed the Saint George's Respiratory Questionnaire (SGRQ) and the EQ-5D Visual Analog Scale (EQ VAS). Change score models were used to investigate the relationship between HRQL and FEV1 and to calculate mean changes in HRQL per FEV1 change categories [decrease (≤ - 100 ml), no change, increase (≥ 100 ml)] after 3 years. Applying hierarchical linear models (HLM), we estimated the cross-sectional between-subject difference and the longitudinal within-subject change of HRQL as related to a FEV1 difference or change.Results: We observed a statistically significant deterioration in SGRQ (total score + 1.3 units) after 3 years, which was completely driven by the activity component (+ 4 units). No significant change was found for the generic EQ VAS. Over the same period, 58% of patients experienced a decrease in FEV1, 28% were recorded as no change in FEV1, and 13% experienced an increase. The relationship between HRQL and FEV1 was found to be approximately linear with decrease in FEV1 being statistically significantly associated with a deterioration in SGRQ (+ 3.20 units). Increase in FEV1 was associated with improvements in SGRQ (- 3.81 units). The associations between change in FEV1 and the EQ VAS were similar. Results of the HLMs were consistent and highly statistically significant, indicating cross-sectional and longitudinal associations. The largest estimates were found for the association between FEV1 and the SGRQ activity domain.Conclusions: Difference and change in FEV1 over time correlate with difference and change in disease-specific and generic HRQL. We conclude, that deterioration of HRQL should induce timely re-examination of physical status and lung function and possibly reassessment of therapeutic regimes.Trial Registration: NCT01245933. Date of registration: 18 November 2010. [ABSTRACT FROM AUTHOR]- Published
- 2020
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32. The association of cognitive functioning as measured by the DemTect with functional and clinical characteristics of COPD: results from the COSYCONET cohort.
- Author
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von Siemens, Sarah Marietta, Perneczky, Robert, Vogelmeier, Claus F., Behr, Jürgen, Kauffmann-Guerrero, Diego, Alter, Peter, Trudzinski, Franziska C., Bals, Robert, Grohé, Christian, Söhler, Sandra, Waschki, Benjamin, Lutter, Johanna I., Welte, Tobias, Jörres, Rudolf A., Kahnert, Kathrin, the COSYCONET study group, Andreas, Stefan, Bewig, Burkhard, Buhl, Roland, and Ewert, Ralf
- Subjects
COGNITIVE ability ,COGNITION disorders ,PATH analysis (Statistics) ,MONTREAL Cognitive Assessment ,OXYGEN in the blood ,CHARACTERISTIC functions ,BLOOD lactate - Abstract
Alterations of cognitive functions have been described in COPD. Our study aimed to disentangle the relationship between the degree of cognitive function and COPD characteristics including quality of life (QoL).Data from 1969 COPD patients of the COSYCONET cohort (GOLD grades 1-4; 1216 male/ 753 female; mean (SD) age 64.9 ± 8.4 years) were analysed using regression and path analysis. The DemTect screening tool was used to measure cognitive function, and the St. George's respiratory questionnaire (SGRQ) to assess disease-specific QoL.DemTect scores were < 9 points in 1.6% of patients and < 13 points in 12% when using the original evaluation algorithm distinguishing between < 60 or > =60 years of age. For statistical reasons, we used the average of both algorithms independent of age in all subsequent analyses. The DemTect scores were associated with oxygen content, 6-min-walking distance (6-MWD), C-reactive protein (CRP), modified Medical Research Council dyspnoea scale (mMRC) and the SGRQ impact score. Conversely, the SGRQ impact score was independently associated with 6-MWD, FVC, mMRC and DemTect. These results were combined into a path analysis model to account for direct and indirect effects. The DemTect score had a small, but independent impact on QoL, irrespective of the inclusion of COPD-specific influencing factors or a diagnosis of cognitive impairment.We conclude that in patients with stable COPD lower oxygen content of blood as a measure of peripheral oxygen supply, lower exercise capacity in terms of 6-MWD, and higher CRP levels were associated with reduced cognitive capacity. Furthermore, a reduction in cognitive capacity was associated with reduced disease-specific quality of life. As a potential clinical implication of this work, we suggest to screen especially patients with low oxygen content and low 6-MWD for cognitive impairment. [ABSTRACT FROM AUTHOR]
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- 2019
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33. Health-related quality of life associates with change in FEV 1 in COPD: results from the COSYCONET cohort.
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Lutter JI, Jörres RA, Kahnert K, Schwarzkopf L, Studnicka M, Karrasch S, Schulz H, Vogelmeier CF, and Holle R
- Subjects
- Aged, Female, Humans, Linear Models, Male, Middle Aged, Prospective Studies, Severity of Illness Index, Surveys and Questionnaires, Forced Expiratory Volume, Pulmonary Disease, Chronic Obstructive physiopathology, Pulmonary Disease, Chronic Obstructive psychology, Quality of Life
- Abstract
Background: Forced expiratory volume in one second (FEV
1 ) characterizes the pathophysiology of COPD and different trajectories of FEV1 decline have been observed in patients with COPD (e.g. gradual or episodic). There is limited information about the development of patient-reported health-related quality of life (HRQL) over the full range of the natural history of COPD. We examined the longitudinal association between change in FEV1 and change in disease-specific and generic HRQL., Methods: We analysed data of 1734 patients with COPD participating in the COSYCONET cohort with up to 3 years of follow-up. Patients completed the Saint George's Respiratory Questionnaire (SGRQ) and the EQ-5D Visual Analog Scale (EQ VAS). Change score models were used to investigate the relationship between HRQL and FEV1 and to calculate mean changes in HRQL per FEV1 change categories [decrease (≤ - 100 ml), no change, increase (≥ 100 ml)] after 3 years. Applying hierarchical linear models (HLM), we estimated the cross-sectional between-subject difference and the longitudinal within-subject change of HRQL as related to a FEV1 difference or change., Results: We observed a statistically significant deterioration in SGRQ (total score + 1.3 units) after 3 years, which was completely driven by the activity component (+ 4 units). No significant change was found for the generic EQ VAS. Over the same period, 58% of patients experienced a decrease in FEV1 , 28% were recorded as no change in FEV1 , and 13% experienced an increase. The relationship between HRQL and FEV1 was found to be approximately linear with decrease in FEV1 being statistically significantly associated with a deterioration in SGRQ (+ 3.20 units). Increase in FEV1 was associated with improvements in SGRQ (- 3.81 units). The associations between change in FEV1 and the EQ VAS were similar. Results of the HLMs were consistent and highly statistically significant, indicating cross-sectional and longitudinal associations. The largest estimates were found for the association between FEV1 and the SGRQ activity domain., Conclusions: Difference and change in FEV1 over time correlate with difference and change in disease-specific and generic HRQL. We conclude, that deterioration of HRQL should induce timely re-examination of physical status and lung function and possibly reassessment of therapeutic regimes., Trial Registration: NCT01245933. Date of registration: 18 November 2010.- Published
- 2020
- Full Text
- View/download PDF
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