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1. Thrombospondin-1 mediates oncogenic Ras-induced senescence in premalignant lung tumors

Author

Baek, Kwan-Hyuck, Bhang, Dongha, Zaslavsky, Alexander, Wang, Liang-Chuan, Vachani, Anil, Kim, Carla F., Albelda, Steven M., Evan, Gerard I., and Ryeom, Sandra

Subjects
Testing, Observations, Research, Properties, Angiogenesis inhibitors -- Properties -- Testing, Cell aging -- Research, Carcinogenesis -- Observations, Lung tumors -- Observations, Cells -- Aging
Abstract

Progression of premalignant lesions is restrained by oncogene-induced senescence. Oncogenic Ras triggers senescence in many organs, including the lung, which exhibits high levels of the angiogenesis inhibitor thrombospondin-1 (TSP-1). The [...]

Published
2013
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