Thrombospondin-1 mediates oncogenic Ras-induced senescence in premalignant lung tumors

Authors :: Baek, Kwan-Hyuck
Bhang, Dongha
Zaslavsky, Alexander
Wang, Liang-Chuan
Vachani, Anil
Kim, Carla F.
Albelda, Steven M.
Evan, Gerard I.
Ryeom, Sandra
Source :: Journal of Clinical Investigation. October 1, 2013, Vol. 123 Issue 10, p4375, 15 p.
Publication Year :: 2013
Abstract: Progression of premalignant lesions is restrained by oncogene-induced senescence. Oncogenic Ras triggers senescence in many organs, including the lung, which exhibits high levels of the angiogenesis inhibitor thrombospondin-1 (TSP-1). The [...]

Subjects :: Testing
Observations
Research
Properties
Angiogenesis inhibitors -- Properties -- Testing
Cell aging -- Research
Carcinogenesis -- Observations
Lung tumors -- Observations
Cells -- Aging

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