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Introduccion El estudio histologico de los polipos nasals no muestra lesiones especificas, pero la infiltracion de la mucosa por eosinofilos parece ser una caracteristica de la poliposis nasal. El objetivo del trabajo es estudiar las posibles relaciones entre algunos aspectos histologicos y clinicos en la poliposis nasal. Asimismo pretendemos comparar la cuantificacion de la eosinofilia tisular segun el numero de eosinofilos por campo con la obtenida porcentualmente respecto al total de celulas inflamatorias. Material y metodo Hemos estudiado a 40 pacientes con poliposis nasal bilateral idiopatica y valoramos las correlaciones existentes entre diversos aspectos clinicos, como el estadio endoscopico y el radiologico, la asociacion con asma e intolerancia a antiinflamatorios no esteroideos, con algunos aspectos histologicos de los polipos nasales, como la frecuencia de metaplasia, fibrosis y grado de infiltracion eosinofilica. Disponemos de un grupo control de 12 sujetos con mucosa nasal sana para la comparacion de nuestros resultados. Resultados La eosinofilia tisular se correlaciona estadisticamente con el estadio clinico y presenta una tendencia a ser mas alta en el sindrome de ASA triada. La medida de la eosinofilia tisular de forma cuantitativa (numero de eosinofilos por campo) se correlaciona con la obtenida porcentualmente (respecto al total de celulas inflamatorias del infiltrado). Conclusiones La infiltracion por eosinofilos de la mucosa nasal es, junto con el edema, la caracteristica histological mas constante de la poliposis nasal y parece ser un factor importante en el comportamiento clinico de la poliposis nasosinusal. La medicion cuantitativa de la eosinofilia tisular es mas rapida y sencilla y con la misma significacion que la porcentual.

Introduction The histological study of nasal polyps does not reveal any specific lesions but eosinophilic infiltration nasal mucosae seems to be characteristic of nasal polyposis. The aim of this work is to study possible links between certain histological and clinical aspects in nasal polyposis. Furthermore, we attempt to compare the quantification of tissue eosinophilia according to the number of eosinophils per field with the percentage figure obtained with respect to the total of inflammatory cells. Material and method We have studied 40 patients with idiopathic bilateral nasal polyposis, assessing the correlations between various clinical aspects such as their endoscopic and radiological status, association with asthma and intolerance to NSAIDs, against histological aspects of nasal polyps such as the frequency of metaplasia, fibrosis, and the degree of eosinophilic infiltration. A group of 12 healthy subjects allowed comparison of our results with healthy nasal mucosa. Results Tissue eosinophilia correlates statistically with clinical staging and tends to be higher in patients with ASA triad. The quantitative measurement of tissue eosinophilia (number of eosinophils per field) correlates with the percentage figure obtained (with respect to the total number of inflammatory cells in the infiltrate). Conclusions Eosinophil infiltration of the nasal mucosa is, together with oedema, the most constant histological characteristic of nasal polyposis and seems to be an important factor in the clinical behaviour of sinonasal polyposis. Quantitative measurement of tissue eosinophilia is easier and quicker to perform and equivalent to percentage evaluation.

Background Eosinophils are possibly the most important inflammatory cells in the pathogenesis of chronic rhinosinusitis with nasal polyposis. Eosinophilic nasal mucosal infiltration is characteristic of nasal polyposis. The aim of this work was to study the possibility of correlations between cytological and tissue eosinophilia in patients with nasal polyposis and with the stage of the disease. If this correlation exists, nasal cytology will be very useful in diagnosis and management of patients with nasal polyposis. Methods We studied 40 patients affected idiopathic nasal polyposis and 12 normal group controls. Qualitative measurements of eosinophils in nasal exudates and in tissue biopsy specimens were performed and the results were compared. Results Nasal cytology and tissue biopsy showed a statistical correlation in the normal as well as in the pathological group. Clinical staging polyposis also correlated with cytological and tissue eosinophilia. Conclusions Nasal cytological eosinophilia is a simple, fast, nontraumatic, and inexpensive method in the evaluation of patients with nasal polyposis. Eosinophilic infiltration of the nasal mucosa is characteristic of nasal polyposis. It correlates with the stage of the disease and tends to be higher in patients with asthma, nasal polyposis, and nonsteroidal anti-inflammatory drug intolerance (acetil salicilic acid triad).

Background Eosinophils are possibly the most important inflammatory cells in the pathogenesis of rhinosinusitis with nasal polyposis. Eosinophil degranulation is the mechanism by which these cells exert their inflammatory action. Knowledge of eosinophil state and degranulation mode therefore may help us to better understand this disease. A study is made of eosinophil state and degranulation mode using transmission electron microscopy (TEM), attempting to establish correlations with certain clinical variables considered to be of importance in patients with nasal polyposis. Methods A prospective TEM study was made to examine 582 eosinophils under 5000× magnification, classifying them according to their state and degranulation mode. The cells originated from 36 cases of nasal polyposis and were catalogued according to the clinical–radiological presentation of the disorder, the presence of asthmatic disease, or acetilsalicilic acid (ASA) triad syndrome (nasal polyposis, asthma, and nonsteroidal anti-inflammatory drug intolerance), and the degree of nasal tissue eosinophilia of the case of origin. Results A total of 30.75% of the eosinophils were inactive, 41.75% exhibited piecemeal degranulation (PMD), 27.5% exhibited cytolysis, and 0.34% were in apoptosis. The degranulation mode was significantly correlated to the clinical and histological parameters studied. Thus, cytolysis tended to be less pronounced and PMD greater, in the cells from cases with intense eosinophilia or severe polyposis (high clinical stage and ASA triad). Conclusion Cytolysis and PMD are the principal degranulation modes of eosinophils in nasal polyposis—apoptosis being very infrequent. Nasal polyposis shows a correlation between eosinophil degranulation mode and the clinical and radiological stage and the degree of tissue eosinophilia of the case of origin.

L OS autores de este trabajo pertenecemos al Servicio de Orientacion Psicopedagogica del Gobierno Foral de Navarra, y desarrollamos nuestra actividad en centros publicos de E.G.B. de Pamplona y comarca. La planificacion y realizacion del mismo se llevo a cabo durante el curso escolar de 1983-1984. Dado que nuestra incidencia profesional se dirige preferentemente a los primeros niveles educativos, y ante la carencia de material especifico para evaluar el desarrollo del lenguaje al inicio de la escolarizacion, proyectamos elaborar un instrumento que nos sirviera de punto de partida para evaluar el lenguaje en primero de preescolar, y programar su ulterior estimulacion. Una vez planificados los objetivos en equipo, planteamos el trabajo a cinco centros publicos: Ermitaganan, San Benito, Baranain I, Baranain II y Cizur, a cuyo profesorado agradecemos no solo su meritoria