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148 results on '"Loverro, Matteo"'

1. Dual inhibition of CDK12 and CDK13 uncovers actionable vulnerabilities in patient-derived ovarian cancer organoids

Author

Cesari, Eleonora, Ciucci, Alessandra, Pieraccioli, Marco, Caggiano, Cinzia, Nero, Camilla, Bonvissuto, Davide, Sillano, Francesca, Buttarelli, Marianna, Piermattei, Alessia, Loverro, Matteo, Camarda, Floriana, Greco, Viviana, De Bonis, Maria, Minucci, Angelo, Gallo, Daniela, Urbani, Andrea, Vizzielli, Giuseppe, Scambia, Giovanni, and Sette, Claudio

Published
2023
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3. Robotic surgery in ovarian cancer

Author

Gallotta, Valerio, Certelli, Camilla, Oliva, Riccardo, Rosati, Andrea, Federico, Alex, Loverro, Matteo, Lodoli, Claudio, Foschi, Nazario, Lathouras, Konstantinos, Fagotti, Anna, and Scambia, Giovanni

Published
2023
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10. Indocyanine green fluorescence applied to gynecologic oncology: beyond sentinel lymph node.

Author

Loverro, Matteo, Bizzarri, Nicolò, Capomacchia, Filippo M., Watrowski, Rafał, Querleu, Denis, Gioè, Alessandro, Naldini, Angelica, Santullo, Francesco, Foschi, Nazario, Fagotti, Anna, Scambia, Giovanni, and Fanfani, Francesco

Abstract

Indocyanine green (ICG), a well-known molecule employed in medicine for over five decades, has emerged as a versatile dye widely embraced across various surgical disciplines. In gynecologic oncology, its prevalent use revolves around the detection of sentinel lymph nodes. However, the true potential of ICG extends beyond this singular application, owing to its pragmatic utility, costeffectiveness, and safety profile. Furthermore, ICG has been introduced in the theranostic landscape, marking a significant juncture in the evolution of its clinical utility. This narrative review aims to describe the expanding horizons of ICG fluorescence in gynecologic oncology, beyond the sentinel lymph node biopsy. The manifold applications reported within this manuscript include: 1) lymphography; 2) angiography; 3) nerve visualization; 4) ICG-driven resections; and 5) theranostic. The extensive exploration across these numerous applications, some of which are still in the preclinical phase, serves as a hypothesis generator, aiming to stimulate the development of clinical studies capable of expanding the use of this drug in our field, enhancing the care of gynecological cancer patients. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Predictive factors of surgical complications after pelvic exenteration for gynecological malignancies: a large single-institution experience

Author

Tortorella, Lucia, primary, Marco, Cintoni, additional, Loverro, Matteo, additional, Carmine, Conte, additional, Persichetti, Eleonora, additional, Bizzarri, Nicolò, additional, Barbara, Costantini, additional, Francesco, Santullo, additional, Foschi, Nazario, additional, Gallotta, Valerio, additional, Avesani, Giacomo, additional, Chiantera, Vito, additional, Ercoli, Alfredo, additional, Fanfani, Francesco, additional, Fagotti, Anna, additional, Mele, Maria Cristina, additional, Restaino, Stefano, additional, Gueli Alletti, Salvatore, additional, Scambia, Giovanni, additional, and Vizzielli, Giuseppe, additional

Published
2024
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12. Corrigendum to “Robotic surgery in ovarian cancer” [Best Pract Res Clin Obst Gynaecol Volume 90 (August 2023) 102391]

Author

Gallotta, Valerio, primary, Certelli, Camilla, additional, Oliva, Riccardo, additional, Rosati, Andrea, additional, Federico, Alex, additional, Loverro, Matteo, additional, Lodoli, Claudio, additional, Foschi, Nazario, additional, Lathouras, Konstantinos, additional, Fagotti, Anna, additional, and Scambia, Giovanni, additional

Published
2023
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16. #1040 Indocyanine green to assess anastomoses perfusion in patients with gynecological cancers undergoing pelvic exenteration

Author

Bizzarri, Nicolò, primary, Foschi, Nazario, additional, Loverro, Matteo, additional, Lancellotti, Guido, additional, Gallotta, Valerio, additional, Costantini, Barbara, additional, Naldini, Angelica, additional, Tortorella, Lucia, additional, Chiantera, Vito, additional, Ercoli, Alfredo, additional, Fagotti, Anna, additional, Fanfani, Francesco, additional, Vizzielli, Giuseppe, additional, and Scambia, Giovanni, additional

Published
2023
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18. Neonatal Encephalopathy

Author

Loverro, Giuseppe, De Cosmo, Lucrezia, Loverro, Matteo, Mastrolia, Salvatore Andrea, Malvasi, Antonio, editor, Tinelli, Andrea, editor, and Di Renzo, Gian Carlo, editor

Published
2017
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20. Role of minimally invasive secondary cytoreduction in patients with recurrent ovarian cancer

Author

Conte, Carmine, Marchetti, Claudia, Loverro, Matteo, Giudice, M. T., Rosati, A., Gallotta, Valerio, Scambia, Giovanni, Fagotti, Anna, Conte C., Marchetti C. (ORCID:0000-0001-7098-8956), Loverro M., Gallotta V., Scambia G. (ORCID:0000-0003-2758-1063), Fagotti A. (ORCID:0000-0001-5579-335X), Conte, Carmine, Marchetti, Claudia, Loverro, Matteo, Giudice, M. T., Rosati, A., Gallotta, Valerio, Scambia, Giovanni, Fagotti, Anna, Conte C., Marchetti C. (ORCID:0000-0001-7098-8956), Loverro M., Gallotta V., Scambia G. (ORCID:0000-0003-2758-1063), and Fagotti A. (ORCID:0000-0001-5579-335X)

Abstract

Objective Retrospective series have shown minimally invasive secondary cytoreductive surgery is a feasible approach in selected cases of recurrent ovarian cancer. However, no predictors of minimally invasive secondary cytoreductive surgery feasibility are currently available. This study aims to identify predictive factors of minimally invasive secondary cytoreductive surgery feasibility and to compare perioperative and survival outcomes in a matched series of recurrent ovarian cancer patients who underwent secondary cytoreduction via an open or minimally invasive surgical approach. Methods We retrospectively identified all platinum-sensitive recurrent epithelial ovarian cancer patients who underwent minimally invasive or laparotomic secondary cytoreductive surgery between January 2013 and July 2020. Each patient underwent a preoperative positron emission tomography (PET) computerized tomography (CT) scan and diagnostic laparoscopy before secondary cytoreductive surgery. A 1:2 propensity score-matched analysis was performed to balance predictive factors of minimally invasive secondary cytoreductive surgery. Results Overall, 276 patients were identified (62 minimally invasive and 214 open), and a complete gross resection was achieved in 262 (94.9%) patients. At multivariate analysis, predictive factors for minimally invasive secondary cytoreductive surgery were neoadjuvant chemotherapy at first diagnosis (p=0.007), site of recurrence (p=0.031), and number of lesions (p=0.001). In the 1:2 propensity-matched population (39 minimally invasive and 78 open), complete gross resection was similar for both groups (p=0.082). Early post-operative complications were significantly higher in the laparotomy (33.3%) than in the minimally invasive surgery (10.3%) group (p=0.004). Only one (2.6%) patient experienced a grade >3 early post-operative complication in the minimally invasive surgery group compared with 13 (16.7%) patients in the open cohort (p<0.001). The median follo

Published
2023

23. Minimally invasive versus open pelvic exenteration in gynecological malignancies: a propensity-matched survival analysis

Author

Bizzarri, Nicolò, primary, Chiantera, Vito, additional, Loverro, Matteo, additional, Sozzi, Giulio, additional, Perrone, Emanuele, additional, Gueli Alletti, Salvatore, additional, Costantini, Barbara, additional, Gallotta, Valerio, additional, Tortorella, Lucia, additional, Fagotti, Anna, additional, Fanfani, Francesco, additional, Ercoli, Alfredo, additional, Scambia, Giovanni, additional, and Vizzielli, Giuseppe, additional

Published
2023
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25. 2022-RA-1341-ESGO Minimally invasive versus open pelvic exenterationin gynecological malignancies: a propensity-matched survival analysis

Author

Bizzarri, Nicolò, primary, Chiantera, Vito, additional, Loverro, Matteo, additional, Sozzi, Giulio, additional, Perrone, Emanuele, additional, Alletti, Salvatore Gueli, additional, Costantini, Barbara, additional, Gallotta, Valerio, additional, Tortorella, Lucia, additional, Fagotti, Anna, additional, Fanfani, Francesco, additional, Ercoli, Alfredo, additional, Scambia, Giovanni, additional, and Vizzielli, Giuseppe, additional

Published
2022
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29. The impact of secondary cytoreductive surgery in platinum sensitive recurrent ovarian cancer treated with upfront neoadjuvant chemotherapy and interval debulking surgery

Author

Bizzarri, Nicolò, primary, Marchetti, Claudia, additional, Conte, Carmine, additional, Loverro, Matteo, additional, Giudice, Maria Teresa, additional, Quagliozzi, Lorena, additional, Distefano, Mariagrazia, additional, Chiantera, Vito, additional, Scambia, Giovanni, additional, and Fagotti, Anna, additional

Published
2022
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30. Laparoscopic Ovarian Transposition with Extraperitonealization of the Infundibulopelvic Ligament for Cervical Cancer in Ten Steps

Author

Bizzarri, Nicolo', Loverro, Matteo, Angeles, M. A., Pedone Anchora, Luigi, Fagotti, Anna, Fanfani, Francesco, Ferrandina, Maria Gabriella, Scambia, Giovanni, Querleu, D., Bizzarri N., Loverro M., Pedone Anchora L., Fagotti A. (ORCID:0000-0001-5579-335X), Fanfani F. (ORCID:0000-0003-1991-7284), Ferrandina G. (ORCID:0000-0003-4672-4197), Scambia G. (ORCID:0000-0003-2758-1063), Bizzarri, Nicolo', Loverro, Matteo, Angeles, M. A., Pedone Anchora, Luigi, Fagotti, Anna, Fanfani, Francesco, Ferrandina, Maria Gabriella, Scambia, Giovanni, Querleu, D., Bizzarri N., Loverro M., Pedone Anchora L., Fagotti A. (ORCID:0000-0001-5579-335X), Fanfani F. (ORCID:0000-0003-1991-7284), Ferrandina G. (ORCID:0000-0003-4672-4197), and Scambia G. (ORCID:0000-0003-2758-1063)

Abstract

Preservation of ovarian function is important for the physical and psychosexual well-being of young patients with cancer. Patients with pelvic malignancies such as cervical or rectal cancer planned for radiotherapy may benefit from ovarian transposition with the aim of moving the ovaries outside the radiation field.1 Different surgical techniques have been reported previously.2,3 With the present video, we aim to standardize the surgical technique of laparoscopic ovarian transposition in ten steps. We present the case of a 30-year-old nulliparous woman diagnosed with grade 3 squamous cell cervical carcinoma having a largest tumor diameter of 41 mm on magnetic resonance imaging (MRI) scan. The tumor was staged as FIGO 2018 stage IIIC1r with a common iliac lymphadenopathy reported on both MRI and positron emission tomography (PET)/computed tomography (CT) scan. The multidisciplinary team recommended exclusive chemoradiation extended to paraaortic area. The patient underwent laparoscopic bilateral salpingectomy and bilateral ovarian transposition with extraperitonealization of the infundibulopelvic ligament. The procedure was divided into the following ten steps: division of uteroovarian ligament, incision of lateral pelvic peritoneum, identification of ureter, incision of medial pelvic peritoneum, skeletonization of the infundibulopelvic ligament, retroperitoneal tunnel in paracolic gutter, creating the window (as high as possible), mobilization of the ovary without torsion, intraperitonealization of the ovary, and fix ovary with clips (Fig. 1). Surgical time was 30 min, with minimal estimated blood loss. No intra- or postoperative complication was recorded. The patient started radiotherapy 14 days after the procedure. In conclusion, we showed that laparoscopic ovarian transposition in cervical cancer before radiotherapy can be standardized in ten steps with encouraging perioperative results, making it an easily reproducible procedure. Ovarian function is reported to

Published
2022

31. The impact of secondary cytoreductive surgery in platinum sensitive recurrent ovarian cancer treated with upfront neoadjuvant chemotherapy and interval debulking surgery

Author

Bizzarri, Nicolo', Marchetti, Claudia, Conte, C., Loverro, Matteo, Giudice, M. T., Quagliozzi, L., Distefano, M., Chiantera, V., Scambia, Giovanni, Fagotti, Anna, Bizzarri N., Marchetti C. (ORCID:0000-0001-7098-8956), Loverro M., Scambia G. (ORCID:0000-0003-2758-1063), Fagotti A. (ORCID:0000-0001-5579-335X), Bizzarri, Nicolo', Marchetti, Claudia, Conte, C., Loverro, Matteo, Giudice, M. T., Quagliozzi, L., Distefano, M., Chiantera, V., Scambia, Giovanni, Fagotti, Anna, Bizzarri N., Marchetti C. (ORCID:0000-0001-7098-8956), Loverro M., Scambia G. (ORCID:0000-0003-2758-1063), and Fagotti A. (ORCID:0000-0001-5579-335X)

Abstract

Objective: The aims of the present study were to assess the oncological outcomes of platinum-sensitive recurrent ovarian cancer patients undergoing secondary cytoreduction (SCS) after treatment with neoadjuvant chemotherapy (NACT) and interval debulking surgery (IDS) at diagnosis and to compare the performance of different selection models in these patients. Methods: Retrospective, observational, single-center cohort study including patients with platinum-sensitive recurrent epithelial ovarian cancer with abdominal/inguinal/cardiophrenic disease between November 2012 and November 2020. Patients were selected as surgical candidates with PET/CT-scan and with diagnostic laparoscopy. Results: 272 patients were included in the study. Of these, 165 (60.7%) patients were treated with PDS at diagnosis and 107 (39.3%) with IDS. SCS was performed in 178 (65.4%) cases, with complete gross resection achieved in 155/178 (87.1%). No progression-free survival (PFS) difference was demonstrated when patients treated with PDS were compared with those treated with NACT+IDS at first diagnosis (median 21 versus 21 months; p = 0.684); no post-recurrence survival (PRS) difference was evident between the two groups (median 81 versus 77 months, respectively; p = 0.574). Current selection models to candidate patients to SCS adequately performed in patients treated with IDS at diagnosis, as well as in the PDS group, with combination of PET/CT-scan and laparoscopy being an accurate tool in prediction of no gross residual disease at SCS in this pre-selected population. Conclusions: Patients with platinum-sensitive recurrent epithelial ovarian cancer treated with NACT/IDS as primary treatment have similar post-recurrence survival outcomes of those treated with PDS. Current models to select patients for SCS can be safely applied to IDS patients.

Published
2022

32. Characteristics and patterns of care of endometrial cancer before and during COVID-19 pandemic

Author

Bogani, G., Scambia, Giovanni, Cimmino, C., Fanfani, Francesco, Costantini, Barbara, Loverro, Matteo, Ferrandina, Maria Gabriella, Landoni, F., Bazzurini, L., Grassi, T., Vitobello, D., Siesto, G., Perrone, A. M., Zanagnolo, V., De Iaco, P., Multinu, F., Ghezzi, F., Casarin, J., Berretta, R., Capozzi, V. A., Zupi, E., Centini, G., Pellegrino, Antonio Agostino, Corso, S., Stevenazzi, G., Montoli, Stefano, Boschi, A. C., Comerci, Gianluca, Greco, Pierfrancesco, Martinello, R., Sopracordevole, F., Giorda, G., Simoncini, T., Caretto, M., Sartori, E., Ferrari, F., Cianci, A., Sarpietro, G., Matarazzo, M. G., Zullo, F., Bifulco, G., Morelli, Marco, Ferrero, A., Biglia, N., Barra, F., Ferrero, S., Maggiore, U. L. R., Cianci, Stefano, Chiantera, V., Ercoli, Alfredo, Sozzi, G., Martoccia, A., Schettini, Sergio Crescenzo, Orlando, T., Cannone, F. G., Ettore, G., Puppo, A., Borghese, M., Martinelli, C., Muzii, L., Di Donato, V., Driul, L., Restaino, S., Bergamini, A., Candotti, G., Bocciolone, L., Plotti, F., Angioli, R., Mantovani, G., Ceccaroni, Marcello, Cassani, C., Dominoni, M., Giambanco, L., Amodeo, Silvia, Leo, Maria Laura, Thomasset, R., Raimondo, D., Seracchioli, R., Malzoni, M., Gorlero, F., Di Luca, M., Busato, E., Kilzie, S., Dell'Acqua, Antonio, Scarfone, G., Vercellini, P., Petrillo, Marco, Dessole, S., Capobianco, G., Ciavattini, A., Delli Carpini, G., Giannella, L., Mereu, L., Tateo, S., Sorbi, F., Fambrini, M., Cicogna, S., Romano, Federica, Ricci, Giuseppe, Trojano, G., Consonni, R., Cantaluppi, S., Lippolis, A., Tinelli, R., D'Ippolito, G., Aguzzoli, L., Mandato, V. D., Palomba, S., Calandra, D., Rosati, M., Gallo, C., Surico, D., Remorgida, V., Ruscitto, F., Beretta, P., Panici, P. B., Raspagliesi, F., Scambia G. (ORCID:0000-0003-2758-1063), Fanfani F. (ORCID:0000-0003-1991-7284), Costantini B., Loverro M., Ferrandina G. (ORCID:0000-0003-4672-4197), Pellegrino A., Montoli S., Comerci G., Greco P., Morelli M., Cianci S., Ercoli A., Schettini S., Ceccaroni M., Amodeo S., Leo L., Dell'acqua A. (ORCID:0000-0002-8697-3115), Petrillo M., Romano F., Ricci G., Bogani, G., Scambia, Giovanni, Cimmino, C., Fanfani, Francesco, Costantini, Barbara, Loverro, Matteo, Ferrandina, Maria Gabriella, Landoni, F., Bazzurini, L., Grassi, T., Vitobello, D., Siesto, G., Perrone, A. M., Zanagnolo, V., De Iaco, P., Multinu, F., Ghezzi, F., Casarin, J., Berretta, R., Capozzi, V. A., Zupi, E., Centini, G., Pellegrino, Antonio Agostino, Corso, S., Stevenazzi, G., Montoli, Stefano, Boschi, A. C., Comerci, Gianluca, Greco, Pierfrancesco, Martinello, R., Sopracordevole, F., Giorda, G., Simoncini, T., Caretto, M., Sartori, E., Ferrari, F., Cianci, A., Sarpietro, G., Matarazzo, M. G., Zullo, F., Bifulco, G., Morelli, Marco, Ferrero, A., Biglia, N., Barra, F., Ferrero, S., Maggiore, U. L. R., Cianci, Stefano, Chiantera, V., Ercoli, Alfredo, Sozzi, G., Martoccia, A., Schettini, Sergio Crescenzo, Orlando, T., Cannone, F. G., Ettore, G., Puppo, A., Borghese, M., Martinelli, C., Muzii, L., Di Donato, V., Driul, L., Restaino, S., Bergamini, A., Candotti, G., Bocciolone, L., Plotti, F., Angioli, R., Mantovani, G., Ceccaroni, Marcello, Cassani, C., Dominoni, M., Giambanco, L., Amodeo, Silvia, Leo, Maria Laura, Thomasset, R., Raimondo, D., Seracchioli, R., Malzoni, M., Gorlero, F., Di Luca, M., Busato, E., Kilzie, S., Dell'Acqua, Antonio, Scarfone, G., Vercellini, P., Petrillo, Marco, Dessole, S., Capobianco, G., Ciavattini, A., Delli Carpini, G., Giannella, L., Mereu, L., Tateo, S., Sorbi, F., Fambrini, M., Cicogna, S., Romano, Federica, Ricci, Giuseppe, Trojano, G., Consonni, R., Cantaluppi, S., Lippolis, A., Tinelli, R., D'Ippolito, G., Aguzzoli, L., Mandato, V. D., Palomba, S., Calandra, D., Rosati, M., Gallo, C., Surico, D., Remorgida, V., Ruscitto, F., Beretta, P., Panici, P. B., Raspagliesi, F., Scambia G. (ORCID:0000-0003-2758-1063), Fanfani F. (ORCID:0000-0003-1991-7284), Costantini B., Loverro M., Ferrandina G. (ORCID:0000-0003-4672-4197), Pellegrino A., Montoli S., Comerci G., Greco P., Morelli M., Cianci S., Ercoli A., Schettini S., Ceccaroni M., Amodeo S., Leo L., Dell'acqua A. (ORCID:0000-0002-8697-3115), Petrillo M., Romano F., and Ricci G.

Abstract

Objective: Coronavirus disease 2019 (COVID-19) outbreak has correlated with the disruption of screening activities and diagnostic assessments. Endometrial cancer (EC) is one of the most common gynecological malignancies and it is often detected at an early stage, because it frequently produces symptoms. Here, we aim to investigate the impact of COVID-19 outbreak on patterns of presentation and treatment of EC patients. Methods: This is a retrospective study involving 54 centers in Italy. We evaluated patterns of presentation and treatment of EC patients before (period 1: March 1, 2019 to February 29, 2020) and during (period 2: April 1, 2020 to March 31, 2021) the COVID-19 outbreak. Results: Medical records of 5,164 EC patients have been retrieved: 2,718 and 2,446 women treated in period 1 and period 2, respectively. Surgery was the mainstay of treatment in both periods (p=0.356). Nodal assessment was omitted in 689 (27.3%) and 484 (21.2%) patients treated in period 1 and 2, respectively (p<0.001). While, the prevalence of patients undergoing sentinel node mapping (with or without backup lymphadenectomy) has increased during the COVID-19 pandemic (46.7% in period 1 vs. 52.8% in period 2; p<0.001). Overall, 1,280 (50.4%) and 1,021 (44.7%) patients had no adjuvant therapy in period 1 and 2, respectively (p<0.001). Adjuvant therapy use has increased during COVID-19 pandemic (p<0.001). Conclusion: Our data suggest that the COVID-19 pandemic had a significant impact on the characteristics and patterns of care of EC patients. These findings highlight the need to implement healthcare services during the pandemic.

Published
2022

33. Characteristics and patterns of care of endometrial cancer before and during COVID-19 pandemic

Author

Bogani, G, Scambia, G, Cimmino, C, Fanfani, F, Costantini, B, Loverro, M, Ferrandina, G, Landoni, F, Bazzurini, L, Grassi, T, Vitobello, D, Siesto, G, Perrone, A, Zanagnolo, V, De Iaco, P, Multinu, F, Ghezzi, F, Casarin, J, Berretta, R, Capozzi, V, Zupi, E, Centini, G, Pellegrino, A, Corso, S, Stevenazzi, G, Montoli, S, Boschi, A, Comerci, G, Greco, P, Martinello, R, Sopracordevole, F, Giorda, G, Simoncini, T, Caretto, M, Sartori, E, Ferrari, F, Cianci, A, Sarpietro, G, Matarazzo, M, Zullo, F, Bifulco, G, Morelli, M, Ferrero, A, Biglia, N, Barra, F, Ferrero, S, Leone Roberti Maggiore, U, Cianci, S, Chiantera, V, Ercoli, A, Sozzi, G, Martoccia, A, Schettini, S, Orlando, T, Cannone, F, Ettore, G, Puppo, A, Borghese, M, Martinelli, C, Muzii, L, Di Donato, V, Driul, L, Restaino, S, Bergamini, A, Candotti, G, Bocciolone, L, Plotti, F, Angioli, R, Mantovani, G, Ceccaroni, M, Cassani, C, Dominoni, M, Giambanco, L, Amodeo, S, Leo, L, Thomasset, R, Raimondo, D, Seracchioli, R, Malzoni, M, Gorlero, F, Di Luca, M, Busato, E, Kilzie, S, Dell'Acqua, A, Scarfone, G, Vercellini, P, Petrillo, M, Dessole, S, Capobianco, G, Ciavattini, A, Delli Carpini, G, Giannella, L, Mereu, L, Tateo, S, Sorbi, F, Fambrini, M, Cicogna, S, Romano, F, Ricci, G, Trojano, G, Consonni, R, Cantaluppi, S, Lippolis, A, Tinelli, R, D'Ippolito, G, Aguzzoli, L, Mandato, V, Palomba, S, Calandra, D, Rosati, M, Gallo, C, Surico, D, Remorgida, V, Ruscitto, F, Beretta, P, Benedetti Panici, P, Raspagliesi, F, Bogani, Giorgio, Scambia, Giovanni, Cimmino, Chiara, Fanfani, Francesco, Costantini, Barbara, Loverro, Matteo, Ferrandina, Gabriella, Landoni, Fabio, Bazzurini, Luca, Grassi, Tommaso, Vitobello, Domenico, Siesto, Gabriele, Perrone, Anna Myriam, Zanagnolo, Vanna, De Iaco, Pierandrea, Multinu, Francesco, Ghezzi, Fabio, Casarin, Jvan, Berretta, Roberto, Capozzi, Vito A, Zupi, Errico, Centini, Gabriele, Pellegrino, Antonio, Corso, Silvia, Stevenazzi, Guido, Montoli, Serena, Boschi, Anna Chiara, Comerci, Giuseppe, Greco, Pantaleo, Martinello, Ruby, Sopracordevole, Francesco, Giorda, Giorgio, Simoncini, Tommaso, Caretto, Marta, Sartori, Enrico, Ferrari, Federico, Cianci, Antonio, Sarpietro, Giuseppe, Matarazzo, Maria Grazia, Zullo, Fulvio, Bifulco, Giuseppe, Morelli, Michele, Ferrero, Annamaria, Biglia, Nicoletta, Barra, Fabio, Ferrero, Simone, Leone Roberti Maggiore, Umberto, Cianci, Stefano, Chiantera, Vito, Ercoli, Alfredo, Sozzi, Giulio, Martoccia, Angela, Schettini, Sergio, Orlando, Teresa, Cannone, Francesco G, Ettore, Giuseppe, Puppo, Andrea, Borghese, Martina, Martinelli, Canio, Muzii, Ludovico, Di Donato, Violante, Driul, Lorenza, Restaino, Stefano, Bergamini, Alice, Candotti, Giorgio, Bocciolone, Luca, Plotti, Francesco, Angioli, Roberto, Mantovani, Giulia, Ceccaroni, Marcello, Cassani, Chiara, Dominoni, Mattia, Giambanco, Laura, Amodeo, Silvia, Leo, Livio, Thomasset, Raphael, Raimondo, Diego, Seracchioli, Renato, Malzoni, Mario, Gorlero, Franco, Di Luca, Martina, Busato, Enrico, Kilzie, Sami, Dell'Acqua, Andrea, Scarfone, Giovanna, Vercellini, Paolo, Petrillo, Marco, Dessole, Salvatore, Capobianco, Giampiero, Ciavattini, Andrea, Delli Carpini, Giovanni, Giannella, Luca, Mereu, Liliana, Tateo, Saverio, Sorbi, Flavia, Fambrini, Massimiliano, Cicogna, Stefania, Romano, Federico, Ricci, Giuseppe, Trojano, Giuseppe, Consonni, Roberto, Cantaluppi, Simona, Lippolis, Antonio, Tinelli, Raffaele, D'Ippolito, Giovanni, Aguzzoli, Lorenzo, Mandato, Vincenzo D, Palomba, Stefano, Calandra, Davide, Rosati, Maurizio, Gallo, Cinzia, Surico, Daniela, Remorgida, Valentino, Ruscitto, Francesco, Beretta, Paolo, Benedetti Panici, Pierluigi, Raspagliesi, Francesco, Bogani, G, Scambia, G, Cimmino, C, Fanfani, F, Costantini, B, Loverro, M, Ferrandina, G, Landoni, F, Bazzurini, L, Grassi, T, Vitobello, D, Siesto, G, Perrone, A, Zanagnolo, V, De Iaco, P, Multinu, F, Ghezzi, F, Casarin, J, Berretta, R, Capozzi, V, Zupi, E, Centini, G, Pellegrino, A, Corso, S, Stevenazzi, G, Montoli, S, Boschi, A, Comerci, G, Greco, P, Martinello, R, Sopracordevole, F, Giorda, G, Simoncini, T, Caretto, M, Sartori, E, Ferrari, F, Cianci, A, Sarpietro, G, Matarazzo, M, Zullo, F, Bifulco, G, Morelli, M, Ferrero, A, Biglia, N, Barra, F, Ferrero, S, Leone Roberti Maggiore, U, Cianci, S, Chiantera, V, Ercoli, A, Sozzi, G, Martoccia, A, Schettini, S, Orlando, T, Cannone, F, Ettore, G, Puppo, A, Borghese, M, Martinelli, C, Muzii, L, Di Donato, V, Driul, L, Restaino, S, Bergamini, A, Candotti, G, Bocciolone, L, Plotti, F, Angioli, R, Mantovani, G, Ceccaroni, M, Cassani, C, Dominoni, M, Giambanco, L, Amodeo, S, Leo, L, Thomasset, R, Raimondo, D, Seracchioli, R, Malzoni, M, Gorlero, F, Di Luca, M, Busato, E, Kilzie, S, Dell'Acqua, A, Scarfone, G, Vercellini, P, Petrillo, M, Dessole, S, Capobianco, G, Ciavattini, A, Delli Carpini, G, Giannella, L, Mereu, L, Tateo, S, Sorbi, F, Fambrini, M, Cicogna, S, Romano, F, Ricci, G, Trojano, G, Consonni, R, Cantaluppi, S, Lippolis, A, Tinelli, R, D'Ippolito, G, Aguzzoli, L, Mandato, V, Palomba, S, Calandra, D, Rosati, M, Gallo, C, Surico, D, Remorgida, V, Ruscitto, F, Beretta, P, Benedetti Panici, P, Raspagliesi, F, Bogani, Giorgio, Scambia, Giovanni, Cimmino, Chiara, Fanfani, Francesco, Costantini, Barbara, Loverro, Matteo, Ferrandina, Gabriella, Landoni, Fabio, Bazzurini, Luca, Grassi, Tommaso, Vitobello, Domenico, Siesto, Gabriele, Perrone, Anna Myriam, Zanagnolo, Vanna, De Iaco, Pierandrea, Multinu, Francesco, Ghezzi, Fabio, Casarin, Jvan, Berretta, Roberto, Capozzi, Vito A, Zupi, Errico, Centini, Gabriele, Pellegrino, Antonio, Corso, Silvia, Stevenazzi, Guido, Montoli, Serena, Boschi, Anna Chiara, Comerci, Giuseppe, Greco, Pantaleo, Martinello, Ruby, Sopracordevole, Francesco, Giorda, Giorgio, Simoncini, Tommaso, Caretto, Marta, Sartori, Enrico, Ferrari, Federico, Cianci, Antonio, Sarpietro, Giuseppe, Matarazzo, Maria Grazia, Zullo, Fulvio, Bifulco, Giuseppe, Morelli, Michele, Ferrero, Annamaria, Biglia, Nicoletta, Barra, Fabio, Ferrero, Simone, Leone Roberti Maggiore, Umberto, Cianci, Stefano, Chiantera, Vito, Ercoli, Alfredo, Sozzi, Giulio, Martoccia, Angela, Schettini, Sergio, Orlando, Teresa, Cannone, Francesco G, Ettore, Giuseppe, Puppo, Andrea, Borghese, Martina, Martinelli, Canio, Muzii, Ludovico, Di Donato, Violante, Driul, Lorenza, Restaino, Stefano, Bergamini, Alice, Candotti, Giorgio, Bocciolone, Luca, Plotti, Francesco, Angioli, Roberto, Mantovani, Giulia, Ceccaroni, Marcello, Cassani, Chiara, Dominoni, Mattia, Giambanco, Laura, Amodeo, Silvia, Leo, Livio, Thomasset, Raphael, Raimondo, Diego, Seracchioli, Renato, Malzoni, Mario, Gorlero, Franco, Di Luca, Martina, Busato, Enrico, Kilzie, Sami, Dell'Acqua, Andrea, Scarfone, Giovanna, Vercellini, Paolo, Petrillo, Marco, Dessole, Salvatore, Capobianco, Giampiero, Ciavattini, Andrea, Delli Carpini, Giovanni, Giannella, Luca, Mereu, Liliana, Tateo, Saverio, Sorbi, Flavia, Fambrini, Massimiliano, Cicogna, Stefania, Romano, Federico, Ricci, Giuseppe, Trojano, Giuseppe, Consonni, Roberto, Cantaluppi, Simona, Lippolis, Antonio, Tinelli, Raffaele, D'Ippolito, Giovanni, Aguzzoli, Lorenzo, Mandato, Vincenzo D, Palomba, Stefano, Calandra, Davide, Rosati, Maurizio, Gallo, Cinzia, Surico, Daniela, Remorgida, Valentino, Ruscitto, Francesco, Beretta, Paolo, Benedetti Panici, Pierluigi, and Raspagliesi, Francesco

Abstract

Objective: Coronavirus disease 2019 (COVID-19) outbreak has correlated with the disruption of screening activities and diagnostic assessments. Endometrial cancer (EC) is one of the most common gynecological malignancies and it is often detected at an early stage, because it frequently produces symptoms. Here, we aim to investigate the impact of COVID-19 outbreak on patterns of presentation and treatment of EC patients. Methods: This is a retrospective study involving 54 centers in Italy. We evaluated patterns of presentation and treatment of EC patients before (period 1: March 1, 2019 to February 29, 2020) and during (period 2: April 1, 2020 to March 31, 2021) the COVID-19 outbreak. Results: Medical records of 5,164 EC patients have been retrieved: 2,718 and 2,446 women treated in period 1 and period 2, respectively. Surgery was the mainstay of treatment in both periods (p=0.356). Nodal assessment was omitted in 689 (27.3%) and 484 (21.2%) patients treated in period 1 and 2, respectively (p<0.001). While, the prevalence of patients undergoing sentinel node mapping (with or without backup lymphadenectomy) has increased during the COVID-19 pandemic (46.7% in period 1 vs. 52.8% in period 2; p<0.001). Overall, 1,280 (50.4%) and 1,021 (44.7%) patients had no adjuvant therapy in period 1 and 2, respectively (p<0.001). Adjuvant therapy use has increased during COVID-19 pandemic (p<0.001). Conclusion: Our data suggest that the COVID-19 pandemic had a significant impact on the characteristics and patterns of care of EC patients. These findings highlight the need to implement healthcare services during the pandemic.

Published
2022

35. Characteristics and patterns of care of endometrial cancer before and during COVID-19 pandemic

Author

Bogani, Giorgio, primary, Scambia, Giovanni, additional, Cimmino, Chiara, additional, Fanfani, Francesco, additional, Costantini, Barbara, additional, Loverro, Matteo, additional, Ferrandina, Gabriella, additional, Landoni, Fabio, additional, Bazzurini, Luca, additional, Grassi, Tommaso, additional, Vitobello, Domenico, additional, Siesto, Gabriele, additional, Perrone, Anna Myriam, additional, Zanagnolo, Vanna, additional, De Iaco, Pierandrea, additional, Multinu, Francesco, additional, Ghezzi, Fabio, additional, Casarin, Jvan, additional, Berretta, Roberto, additional, Capozzi, Vito A, additional, Zupi, Errico, additional, Centini, Gabriele, additional, Pellegrino, Antonio, additional, Corso, Silvia, additional, Stevenazzi, Guido, additional, Montoli, Serena, additional, Boschi, Anna Chiara, additional, Comerci, Giuseppe, additional, Greco, Pantaleo, additional, Martinello, Ruby, additional, Sopracordevole, Francesco, additional, Giorda, Giorgio, additional, Simoncini, Tommaso, additional, Caretto, Marta, additional, Sartori, Enrico, additional, Ferrari, Federico, additional, Cianci, Antonio, additional, Sarpietro, Giuseppe, additional, Matarazzo, Maria Grazia, additional, Zullo, Fulvio, additional, Bifulco, Giuseppe, additional, Morelli, Michele, additional, Ferrero, Annamaria, additional, Biglia, Nicoletta, additional, Barra, Fabio, additional, Ferrero, Simone, additional, Leone Roberti Maggiore, Umberto, additional, Cianci, Stefano, additional, Chiantera, Vito, additional, Ercoli, Alfredo, additional, Sozzi, Giulio, additional, Martoccia, Angela, additional, Schettini, Sergio, additional, Orlando, Teresa, additional, Cannone, Francesco G, additional, Ettore, Giuseppe, additional, Puppo, Andrea, additional, Borghese, Martina, additional, Martinelli, Canio, additional, Muzii, Ludovico, additional, Di Donato, Violante, additional, Driul, Lorenza, additional, Restaino, Stefano, additional, Bergamini, Alice, additional, Candotti, Giorgio, additional, Bocciolone, Luca, additional, Plotti, Francesco, additional, Angioli, Roberto, additional, Mantovani, Giulia, additional, Ceccaroni, Marcello, additional, Cassani, Chiara, additional, Dominoni, Mattia, additional, Giambanco, Laura, additional, Amodeo, Silvia, additional, Leo, Livio, additional, Thomasset, Raphael, additional, Raimondo, Diego, additional, Seracchioli, Renato, additional, Malzoni, Mario, additional, Gorlero, Franco, additional, Di Luca, Martina, additional, Busato, Enrico, additional, Kilzie, Sami, additional, Dell'Acqua, Andrea, additional, Scarfone, Giovanna, additional, Vercellini, Paolo, additional, Petrillo, Marco, additional, Dessole, Salvatore, additional, Capobianco, Giampiero, additional, Ciavattini, Andrea, additional, Delli Carpini, Giovanni, additional, Giannella, Luca, additional, Mereu, Liliana, additional, Tateo, Saverio, additional, Sorbi, Flavia, additional, Fambrini, Massimiliano, additional, Cicogna, Stefania, additional, Romano, Federico, additional, Ricci, Giuseppe, additional, Trojano, Giuseppe, additional, Consonni, Roberto, additional, Cantaluppi, Simona, additional, Lippolis, Antonio, additional, Tinelli, Raffaele, additional, D'Ippolito, Giovanni, additional, Aguzzoli, Lorenzo, additional, Mandato, Vincenzo D, additional, Palomba, Stefano, additional, Calandra, Davide, additional, Rosati, Maurizio, additional, Gallo, Cinzia, additional, Surico, Daniela, additional, Remorgida, Valentino, additional, Ruscitto, Francesco, additional, Beretta, Paolo, additional, Benedetti Panici, Pierluigi, additional, and Raspagliesi, Francesco, additional

Published
2022
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36. Indocyanine Green to Assess Vascularity of Ileal Conduit Anastomosis During Pelvic Exenteration for Recurrent/Persistent Gynecological Cancer: A Pilot Study

Author

Bizzarri, Nicolò, primary, Foschi, Nazario, additional, Loverro, Matteo, additional, Tortorella, Lucia, additional, Santullo, Francesco, additional, Rosati, Andrea, additional, Gueli Alletti, Salvatore, additional, Costantini, Barbara, additional, Gallotta, Valerio, additional, Ferrandina, Gabriella, additional, Fagotti, Anna, additional, Fanfani, Francesco, additional, Ercoli, Alfredo, additional, Chiantera, Vito, additional, Scambia, Giovanni, additional, and Vizzielli, Giuseppe, additional

Published
2021
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39. Indocyanine Green to Assess Vascularity of Ileal Conduit Anastomosis During Pelvic Exenteration for Recurrent/Persistent Gynecological Cancer: A Pilot Study

Author

Bizzarri, N., Foschi, Nazario, Loverro, Matteo, Tortorella, L., Santullo, F., Rosati, A., Gueli Alletti, Salvatore, Costantini, Barbara, Gallotta, Valerio, Ferrandina, Maria Gabriella, Fagotti, Anna, Fanfani, Francesco, Ercoli, Alfredo, Chiantera, V., Scambia, Giovanni, Vizzielli, Giuseppe, Foschi N., Loverro M., Gueli Alletti S., Costantini B., Gallotta V., Ferrandina G. (ORCID:0000-0003-4672-4197), Fagotti A. (ORCID:0000-0001-5579-335X), Fanfani F. (ORCID:0000-0003-1991-7284), Ercoli A., Scambia G. (ORCID:0000-0003-2758-1063), Vizzielli G., Bizzarri, N., Foschi, Nazario, Loverro, Matteo, Tortorella, L., Santullo, F., Rosati, A., Gueli Alletti, Salvatore, Costantini, Barbara, Gallotta, Valerio, Ferrandina, Maria Gabriella, Fagotti, Anna, Fanfani, Francesco, Ercoli, Alfredo, Chiantera, V., Scambia, Giovanni, Vizzielli, Giuseppe, Foschi N., Loverro M., Gueli Alletti S., Costantini B., Gallotta V., Ferrandina G. (ORCID:0000-0003-4672-4197), Fagotti A. (ORCID:0000-0001-5579-335X), Fanfani F. (ORCID:0000-0003-1991-7284), Ercoli A., Scambia G. (ORCID:0000-0003-2758-1063), and Vizzielli G.

Abstract

Introduction: Pelvic exenteration performed for recurrent/persistent gynecological malignancies has been associated with urological short- and long-term morbidity due to altered vascularization of tissues for previous radiotherapy. The aims of the present study were to describe the use of intravenous indocyanine green (ICG) to assess vascularity of urinary diversion (UD) after pelvic exenteration for gynecologic cancers, to evaluate the feasibility and safety of this technique, and to assess the postoperative complications. Methods: Prospective, observational, single-center, pilot study including consecutive patients undergoing anterior or total pelvic exenteration due to persistent/recurrent gynecologic cancers between August 2020 and March 2021 at Fondazione Policlinico Gemelli IRCCS, Rome, Italy. All patients underwent intravenous injection of 3–6 ml of ICG (1.25 mg/ml) once the UD was completed. A near-infrared camera was used to evaluate ICG perfusion of anastomoses (ileum–ileum, right and left ureter with small bowel, and colostomy or colorectal sides of anastomosis) a few seconds after ICG injection. Results: Fifteen patients were included in the study. No patient reported adverse reactions to ICG injection. Only 3/15 patients (20.0%) had an optimal ICG perfusion in all anastomoses. The remaining 12 (80.0%) patients had at least one ICG deficit; the most common ICG deficit was on the left ureter: 3 (20.0%) vs. 1 (6.7%) patient had no ICG perfusion on the left vs. right ureter, respectively (p = 0.598). 8/15 (53.3%) and 6/15 (40.0%) patients experienced grade ≥3 30-day early and late postoperative complications, respectively. Of these, two patients had early and one had late postoperative complications directly related to poor perfusion of anastomosis (UD leak, ileum–ileum leak, and benign ureteric stricture); all these cases had a suboptimal intraoperative ICG perfusion. Conclusion: The use of ICG to intraoperatively assess the anastomosis perfusion at time o

Published
2021

40. Minimal residual disease at primary debulking surgery versus complete tumor resection at interval debulking surgery in advanced epithelial ovarian cancer: A survival analysis

Author

Ghirardi, V., Moruzzi, M. C., Bizzarri, N., Vargiu, V., D'Indinosante, Marco, Garganese, Giorgia, Pasciuto, Tina, Loverro, Matteo, Scambia, Giovanni, Fagotti, Anna, D'Indinosante M., Garganese G. (ORCID:0000-0002-4209-5285), Pasciuto T. (ORCID:0000-0003-2959-8571), Loverro M., Scambia G. (ORCID:0000-0003-2758-1063), Fagotti A. (ORCID:0000-0001-5579-335X), Ghirardi, V., Moruzzi, M. C., Bizzarri, N., Vargiu, V., D'Indinosante, Marco, Garganese, Giorgia, Pasciuto, Tina, Loverro, Matteo, Scambia, Giovanni, Fagotti, Anna, D'Indinosante M., Garganese G. (ORCID:0000-0002-4209-5285), Pasciuto T. (ORCID:0000-0003-2959-8571), Loverro M., Scambia G. (ORCID:0000-0003-2758-1063), and Fagotti A. (ORCID:0000-0001-5579-335X)

Abstract

Objectives: To compare survival outcomes and peri-operative complications in patients with advanced ovarian cancer with 1–10 mm residual disease (RD) at primary debulking surgery (PDS) versus those achieving no gross residual disease (NGR) at interval debulking surgery (IDS). Methods: Patients operated with the intent of complete cytoreduction for epithelial ovarian/fallopian tube/primary peritoneal cancer, FIGO stage IIIC-IV, RD 1–10 mm at PDS and NGR at IDS, between 01/2010 and 12/2016, were retrospectively included. All patients had at least 2-years of follow-up completed. Results: 207 patients were included (59 PDS and 148 IDS). Patients in PDS group were younger and had a higher surgical complexity score. There was a higher rate of intra- and major early post-operative complications in the group of PDS vs IDS (16.9% vs 1.3% and 28.8% vs 2.0%, p < 0.0001 respectively). After a median follow up of 56.4 months (range 59.2–65.4), 117 (56.5%) patients died of disease in the whole population. Forty-eight (81.4%) patients had progression/recurrent disease in the PDS group and 120 (81.1%) in the IDS group. Median PFS was 16.2 months and 18.9 months for PDS and IDS group, respectively (p = 0.111). Median OS was 41.4 months and 52.4 months for PDS and IDS group, respectively (p = 0.022). Conclusions: IDS should be considered the preferred treatment in case millimetric residual disease is expected at PDS in view of the superimposable PFS and the reduced number of perioperative complications.

Published
2020

46. Comparison of robotic and laparoscopic radical type-B and C hysterectomy for cervical cancer: long term-outcomes

Author

Pellegrino, Antonio, Damiani, Gianluca Raffaello, Loverro, Matteo, Pirovano, Cecilia, Fachechi, Giorgio, Corso, Silvia, and Trojano, Giuseppe

Subjects
Adult, Time Factors, complications, long term follow-up, cervical cancer, overall survival, Carcinoma, Operative Time, Uterine Cervical Neoplasms, Middle Aged, Hysterectomy, Disease-Free Survival, Cohort Studies, Survival Rate, Treatment Outcome, laparoscopic radical hysterectomy, Robotic Surgical Procedures, robotic radical hysterectomy, Humans, Original Article, Female, Laparoscopy, progression-free survival, Neoplasm Staging
Abstract

Study Objective: To compare the clinical and oncologic outcomes of Robotic radical hysterectomy (RRH) vs Laparoscopic radical hysterectomy (TLRH) in patients with cervical carcinoma. Design: Long term follow-up in a prospective study between March 2010 to March 2016. Setting: Oncological referral center, department of gynecology and obstetrics of Alessandro Manzoni Hospital, department of gynecology, University of San Gerardo Monza, Milan. Patients: 52 patients with cervical carcinoma, matched by age, body mass index, tumor size, International Federation of Gynecology and Obstetrics (FIGO) stage, comorbidity, previous neoadjuvant chemotherapy, histology type, and tumor grade to obtain homogeneous samples. Interventions: Patients with FIGO stage IA2 or IB1 with a tumor size less than or equal to 2 cm underwent RR type B. RR-Type C1 was performed in stage IB1, with a tumor size larger than 2 cm, or in patients previously treated with NACT (IB2). In all cases Pelvic lymphadenectomy was performed for the treatment of cervical cancer. Measurements and main results: Surgical time was similar for both the 2 groups. RRH was associated with significantly less (EBL) estimated blood loss (P=0,000). Median number pelvic lymph nodes was similar, but a major number of nodes was observed in RRH group (35.58 vs 24.23; P=0,050). The overall median length of follow-up was 59 months (range: 9-92) and 30 months (range: 90-6) for RRH and TLRH group respectively. Overall survival rate (OSR) was 100% for RRH group and 83.4% for LTRH group. The DFS (disease free survival rate) was of 97% and 89% in RRH and LTRH group respectively. No significant difference was reported in HS (hospital stay). Conclusions: RRH is safe and feasible and is associated with an improved intraoperative results and clinical oncological outcomes. The present study showed that robotic surgery, in comparison to laparoscopic approach, was associated with better perioperative outcomes because of a decrease of EBL, and similar operative time, HS and complication rate, without neglecting the long-term optimal oncologic outcomes. (www.actabiomedica.it)

Published
2017

48. Uterine Fibroid Torsion during Pregnancy: A Case of Laparotomic Myomectomy at 18 Weeks’ Gestation with Systematic Review of the Literature

Author

Basso, Annachiara, Catalano, Mariana Rita, Loverro, Giuseppe, Nocera, Serena, Di Naro, Edoardo, Loverro, Matteo, Natrella, Mariateresa, and Mastrolia, Salvatore Andrea

Subjects
Article Subject
Abstract

Uterine myomas are the most common benign growths affecting female reproductive system, occurring in 20–40% of women, whereas the incidence rate in pregnancy is estimated from 0.1 to 3.9%. The lower incidence in pregnancy is due to the association with infertility and low pregnancy rates and implantation rates after in vitro fertilization treatment. Uterine myomas, usually, are asymptomatic during pregnancy. However, occasionally, pedunculated fibroids torsion or other superimposed complications may cause acute abdominal pain. There are many controversies in performing myomectomy during cesarean section because of the risk of hemorrhage. Nevertheless, the majority of indication arises before labor and delivery due to acute symptoms leading to a discussion regarding the need for intervention during pregnancy. Therefore, we present a case of successful multiple laparotomic myomectomy at 17 + 2 weeks of gestational age and a systematic review of the literature in order to clarify the approach to this pathologic condition and its effect on pregnancy outcome.

Published
2017
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49. Optimal Residual Disease At Primary Debulking Surgery Versus Complete Tumor Resection At interval Debulking Surgery in Advanced Epithelial Ovarian Cancer : a Case-Control Survival Analysis

Author

Loverro, Matteo

Abstract

Objectives: To compare survival outcomes between patients with 1-10 mm residual disease (RD) at primary debulking surgery (PDS) versus those achieving no gross residual disease (NGR) at interval debulking surgery (IDS). Primary endpoint was progression free survival (PFS). Secondary endpoint were overall survival (OS) and peri-operative complications.Methods: We retrospectively reviewed advanced ovarian cancer patients treated in our Institution from 1/2010 to 12/2016 with the intent of complete cytoreduction. 207 patients were included. Among them, 59 were allocated in PDS group (Cases) and 148 in IDS group (Controls). Patients were matched for clinicopathologic characteristics and appropriate statistical tests were used.Results: No significant differences were found between the two groups, except for a difference in median age at diagnosis, being IDS patients older than women included in PDS group (55 years in PDS vs. 62 years in IDS; p8 who were selected for IDS compared to women undergoing PDS [Table 3].Conclusions: Patients receiving NGR at IDS have the same PFS compared to patients with millimetric RD at PDS but with less perioperative complications. OS results could be related to second-line treatment and selection criteria, with a potential difference in chemosensitivity between the two groups. Research efforts to identify pre-treatment criteria of response to chemotherapy are encouraged to improve patientsu2019 treatment selection in the personalized medicine era.

Published
2017

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