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The impact of secondary cytoreductive surgery in platinum sensitive recurrent ovarian cancer treated with upfront neoadjuvant chemotherapy and interval debulking surgery

Authors :
Bizzarri, Nicolo'
Marchetti, Claudia
Conte, C.
Loverro, Matteo
Giudice, M. T.
Quagliozzi, L.
Distefano, M.
Chiantera, V.
Scambia, Giovanni
Fagotti, Anna
Bizzarri N.
Marchetti C. (ORCID:0000-0001-7098-8956)
Loverro M.
Scambia G. (ORCID:0000-0003-2758-1063)
Fagotti A. (ORCID:0000-0001-5579-335X)
Bizzarri, Nicolo'
Marchetti, Claudia
Conte, C.
Loverro, Matteo
Giudice, M. T.
Quagliozzi, L.
Distefano, M.
Chiantera, V.
Scambia, Giovanni
Fagotti, Anna
Bizzarri N.
Marchetti C. (ORCID:0000-0001-7098-8956)
Loverro M.
Scambia G. (ORCID:0000-0003-2758-1063)
Fagotti A. (ORCID:0000-0001-5579-335X)
Publication Year :
2022

Abstract

Objective: The aims of the present study were to assess the oncological outcomes of platinum-sensitive recurrent ovarian cancer patients undergoing secondary cytoreduction (SCS) after treatment with neoadjuvant chemotherapy (NACT) and interval debulking surgery (IDS) at diagnosis and to compare the performance of different selection models in these patients. Methods: Retrospective, observational, single-center cohort study including patients with platinum-sensitive recurrent epithelial ovarian cancer with abdominal/inguinal/cardiophrenic disease between November 2012 and November 2020. Patients were selected as surgical candidates with PET/CT-scan and with diagnostic laparoscopy. Results: 272 patients were included in the study. Of these, 165 (60.7%) patients were treated with PDS at diagnosis and 107 (39.3%) with IDS. SCS was performed in 178 (65.4%) cases, with complete gross resection achieved in 155/178 (87.1%). No progression-free survival (PFS) difference was demonstrated when patients treated with PDS were compared with those treated with NACT+IDS at first diagnosis (median 21 versus 21 months; p = 0.684); no post-recurrence survival (PRS) difference was evident between the two groups (median 81 versus 77 months, respectively; p = 0.574). Current selection models to candidate patients to SCS adequately performed in patients treated with IDS at diagnosis, as well as in the PDS group, with combination of PET/CT-scan and laparoscopy being an accurate tool in prediction of no gross residual disease at SCS in this pre-selected population. Conclusions: Patients with platinum-sensitive recurrent epithelial ovarian cancer treated with NACT/IDS as primary treatment have similar post-recurrence survival outcomes of those treated with PDS. Current models to select patients for SCS can be safely applied to IDS patients.

Details

Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1330710139
Document Type :
Electronic Resource