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1. Effects of azithromycin and doxycycline on the vaginal microbiota of women with urogenital Chlamydia trachomatis infection: a substudy of the Chlazidoxy randomized controlled trial

Author

Baita, Dounia, Ouziel-Duretz, Catherine, Poudens, Béatrice, Brun, Raquel, Jouvert, Sophie, Tesson, Aurore, Carrière, Jennifer, Diaz, Marie, Forget, Camille, Le Hen, Isabelle, Ahano-Ducourneau, France, Van, Delphine Ha, Robert, Pauline, Brun, Fabienne, Lhospital, Estelle, Bardou, Julie, Guegan, Annaïg, Moura, Sandy Ramloll, Leriche, Céline, De Cussy, Alix, Malfait, Marlène, Rychen, Charlotte, Martinet, Pervenche, Kugeler, Audrey, Barriere, Lisa, Gutierrez, Laura, Robert, Jean-Luc, Saule, Julie, Bergamaschi, Viviana, Soltana, Sana Ben, Aymar-Moulene, Dominique, Bernier, Claire, Lecompte, Anne-Sophie, Gregoire, Antoine, Girard, Thomas, Naccache, Marie-Astrid, Lefebvre, Philippe, Crombe, Pauline, Bulot, Christine, Rolland, Anne-Laure, Dernivoix, Katy, Trouillet, Camille, Trignol-Viguier, Nathalie, Blin-Zbiegiel, Elisabeth, Boissinot, Mélanie, Joly, Bruno, Dubreuil, Anne, Mathieu, Camille, Pragout, David, Bébéar, Cécile, Grob, Anne, Zaffreya, Sophie, Le Naour, Erwan, Gibaud, Anne Sophie, Lanotte, Philippe, Vachée, Anne, Loubinoux, Julien, Touati, Arabella, Balcon, Carla, Roussillon, Caroline, Ghezzoul, Bellabes, Perry, Frédéric, Turuban, Christelle, Rapin, Sabine, Pastor, Christine, Cavellec, Morane, Manvri, Ernesto Paredes, Albane, Sonia, Ghiringhelli, Eva, Pantin, Karen, Kret, Marion, Lhomme, Edouard, Garreau, Damien, Galet, Jérôme, Tamarelle, Jeanne, Penaud, Benjamin, Tyssandier, Benjamin, Guichoux, Erwan, de Barbeyrac, Bertille, and Peuchant, Olivia

Published
2023
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2. Doxycycline versus azithromycin for the treatment of anorectal Chlamydia trachomatis infection in women concurrent with vaginal infection (CHLAZIDOXY study): a multicentre, open-label, randomised, controlled, superiority trial

Author

Ouziel-Duretz, Catherine, Poudens, Béatrice, Brun, Raquel, Jouvert, Sophie, Tesson, Aurore, Carrière, Jennifer, Diaz, Marie, Forget, Camille, Ahano-Ducourneau, France, Ha Van, Delphine, Robert, Pauline, Brun, Fabienne, Lhospital, Estelle, Bardou, Julie, Guegan, Annaïg, Ramloll Moura, Sandy, Leriche, Céline, De Cussy, Alix, Malfait, Marlène, Rychen, Charlotte, Kugeler, Audrey, Barriere, Lisa, Gutierrez, Laura, Robert, Jean-Luc, Saule, Julie, Bergamaschi, Viviana, Ben Soltana, Sana, Aymar-Moulene, Dominique, Lecompte, Anne-Sophie, Grégoire, Antoine, Naccache, Marie-Astrid, Crombe, Pauline, Bulot, Christine, Rolland, Anne-Laure, Blin-Zbiegiel, Elisabeth, Boissinot, Mélanie, Joly, Bruno, Dubreuil, Anne, Mathieu, Camille, Pragout, David, Zaffreya, Sophie, Touati, Arabella, Balcon, Carla, Perry, Frédéric, Turuban, Christelle, Rapin, Sabine, Pastor, Christine, Cavellec, Morane, Paredes Manyari, Ernesto, Albane, Soria, Dernivoix, Katy, Trouillet, Camille, Ghiringelli, Eva, Pantin, Karen, Garreau, Damien, Galet, Jérôme, Peuchant, Olivia, Lhomme, Edouard, Martinet, Pervenche, Grob, Anne, Baïta, Dounia, Bernier, Claire, Gibaud, Sophie Anne, Le Hen, Isabelle, Le Naour, Erwan, Trignol-Viguier, Nathalie, Lanotte, Philippe, Lefebvre, Philippe, Vachée, Anne, Girard, Thomas, Loubinoux, Julien, Bébéar, Cécile, Ghezzoul, Bellabes, Roussillon, Caroline, Kret, Marion, and de Barbeyrac, Bertille

Published
2022
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3. High-level expression of chromosomally encoded SHV-1 β-lactamase reduces the susceptibility to cefiderocol of clinical isolates of Klebsiella pneumoniae

Author

Charfi, Rym, primary, Tazi, Asmaa, additional, Sereme, Youssouf, additional, Plainvert, Céline, additional, Poupet, Hélène, additional, Doloy, Alexandra, additional, Guyonnet, Cécile, additional, Morand, Philippe, additional, Loubinoux, Julien, additional, Poyart, Claire, additional, and Mammeri, Hedi, additional

Published
2024
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4. Multicentric evaluation of BioFire FilmArray Pneumonia Panel for rapid bacteriological documentation of pneumonia

Author

Alviset, Sophie, Armand-Lefèvre, Laurence, Baldeyrou, Marion, Becker, Agathe, Boibieux, André, Bonacorsi, Stéphane, Burucoa, Christophe, Cambau, Emmanuelle, Casalegno, Jean-Sébastien, Cointe, Aurélie, Cremniter, Julie, Destras, Grégory, Duquaire, Paul, Geslain, Guillaume, Gustave, Claude-Alexandre, Jacquier, Hervé, Kouatchet, Achille, Lecorche, Emmanuel, Lejeune, Manon, Lina, Bruno, Mahieu, Rafaël, Maamar, Adel, Michaud, Anthony, Monnard, Céline, Montravers, Philippe, Neuwirth, Catherine, Péan de Ponfilly, Gauthier, Pichon, Maxime, Plouzeau, Chloé, Poyart, Claire, Quenot, Jean-Pierre, Rzepecki, Vincent, Stéphan, Robin, Timsit, Jean-François, Tran-Dinh, Alexy, Vandenesch, François, Vigier, Emmanuelle, Gastli, Nabil, Loubinoux, Julien, Daragon, Matthieu, Lavigne, Jean-Philippe, Saint-Sardos, Pierre, Pailhoriès, Hélène, Lemarié, Carole, Benmansour, Hanaa, d’Humières, Camille, Broutin, Lauranne, Dauwalder, Olivier, Levy, Michael, Auger, Gabriel, Kernéis, Solen, and Cattoir, Vincent

Published
2021
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7. Effects of azithromycin and doxycycline on the vaginal microbiota of women with urogenital Chlamydia trachomatis infection: a substudy of the Chlazidoxy randomized controlled trial

Author

Tamarelle, Jeanne, primary, Penaud, Benjamin, additional, Tyssandier, Benjamin, additional, Guichoux, Erwan, additional, de Barbeyrac, Bertille, additional, Peuchant, Olivia, additional, Baita, Dounia, additional, Ouziel-Duretz, Catherine, additional, Poudens, Béatrice, additional, Brun, Raquel, additional, Jouvert, Sophie, additional, Tesson, Aurore, additional, Carrière, Jennifer, additional, Diaz, Marie, additional, Forget, Camille, additional, Le Hen, Isabelle, additional, Ahano-Ducourneau, France, additional, Van, Delphine Ha, additional, Robert, Pauline, additional, Brun, Fabienne, additional, Lhospital, Estelle, additional, Bardou, Julie, additional, Guegan, Annaïg, additional, Moura, Sandy Ramloll, additional, Leriche, Céline, additional, De Cussy, Alix, additional, Malfait, Marlène, additional, Rychen, Charlotte, additional, Martinet, Pervenche, additional, Kugeler, Audrey, additional, Barriere, Lisa, additional, Gutierrez, Laura, additional, Robert, Jean-Luc, additional, Saule, Julie, additional, Bergamaschi, Viviana, additional, Ben Soltana, Sana, additional, Aymar-Moulene, Dominique, additional, Bernier, Claire, additional, Lecompte, Anne-Sophie, additional, Gregoire, Antoine, additional, Girard, Thomas, additional, Naccache, Marie-Astrid, additional, Lefebvre, Philippe, additional, Crombe, Pauline, additional, Bulot, Christine, additional, Rolland, Anne-Laure, additional, Trignol-Viguier, Nathalie, additional, Blin-Zbiegiel, Elisabeth, additional, Boissinot, Mélanie, additional, Joly, Bruno, additional, Dubreuil, Anne, additional, Mathieu, Camille, additional, Pragout, David, additional, Bébéar, Cécile, additional, Grob, Anne, additional, Zaffreya, Sophie, additional, Le Naour, Erwan, additional, Gibaud, Anne Sophie, additional, Lanotte, Philippe, additional, Vachée, Anne, additional, Loubinoux, Julien, additional, Touati, Arabella, additional, Balcon, Carla, additional, Roussillon, Caroline, additional, Ghezzoul, Bellabes, additional, Perry, Frédéric, additional, Turuban, Christelle, additional, Rapin, Sabine, additional, Pastor, Christine, additional, Cavellec, Morane, additional, Manvri, Ernesto Paredes, additional, Albane, Sonia, additional, Dernivoix, Katy, additional, Trouillet, Camille, additional, Ghiringhelli, Eva, additional, Pantin, Karen, additional, Kret, Marion, additional, Lhomme, Edouard, additional, Garreau, Damien, additional, and Galet, Jérôme, additional

Published
2023
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8. Doxycycline versus azithromycin for the treatment of anorectal Chlamydia trachomatis infection in women concurrent with vaginal infection (CHLAZIDOXY study): a multicentre, open-label, randomised, controlled, superiority trial

Author

Peuchant, Olivia, primary, Lhomme, Edouard, additional, Martinet, Pervenche, additional, Grob, Anne, additional, Baïta, Dounia, additional, Bernier, Claire, additional, Gibaud, Sophie Anne, additional, Le Hen, Isabelle, additional, Le Naour, Erwan, additional, Trignol-Viguier, Nathalie, additional, Lanotte, Philippe, additional, Lefebvre, Philippe, additional, Vachée, Anne, additional, Girard, Thomas, additional, Loubinoux, Julien, additional, Bébéar, Cécile, additional, Ghezzoul, Bellabes, additional, Roussillon, Caroline, additional, Kret, Marion, additional, de Barbeyrac, Bertille, additional, Ouziel-Duretz, Catherine, additional, Poudens, Béatrice, additional, Brun, Raquel, additional, Jouvert, Sophie, additional, Tesson, Aurore, additional, Carrière, Jennifer, additional, Diaz, Marie, additional, Forget, Camille, additional, Ahano-Ducourneau, France, additional, Ha Van, Delphine, additional, Robert, Pauline, additional, Brun, Fabienne, additional, Lhospital, Estelle, additional, Bardou, Julie, additional, Guegan, Annaïg, additional, Ramloll Moura, Sandy, additional, Leriche, Céline, additional, De Cussy, Alix, additional, Malfait, Marlène, additional, Rychen, Charlotte, additional, Kugeler, Audrey, additional, Barriere, Lisa, additional, Gutierrez, Laura, additional, Robert, Jean-Luc, additional, Saule, Julie, additional, Bergamaschi, Viviana, additional, Ben Soltana, Sana, additional, Aymar-Moulene, Dominique, additional, Lecompte, Anne-Sophie, additional, Grégoire, Antoine, additional, Naccache, Marie-Astrid, additional, Crombe, Pauline, additional, Bulot, Christine, additional, Rolland, Anne-Laure, additional, Blin-Zbiegiel, Elisabeth, additional, Boissinot, Mélanie, additional, Joly, Bruno, additional, Dubreuil, Anne, additional, Mathieu, Camille, additional, Pragout, David, additional, Zaffreya, Sophie, additional, Touati, Arabella, additional, Balcon, Carla, additional, Perry, Frédéric, additional, Turuban, Christelle, additional, Rapin, Sabine, additional, Pastor, Christine, additional, Cavellec, Morane, additional, Paredes Manyari, Ernesto, additional, Albane, Soria, additional, Dernivoix, Katy, additional, Trouillet, Camille, additional, Ghiringelli, Eva, additional, Pantin, Karen, additional, Garreau, Damien, additional, and Galet, Jérôme, additional

Published
2022
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10. Multicentric evaluation of BioFire FilmArray Pneumonia Panel for rapid bacteriological documentation of pneumonia

Author

Gastli, Nabil, primary, Loubinoux, Julien, additional, Daragon, Matthieu, additional, Lavigne, Jean-Philippe, additional, Saint-Sardos, Pierre, additional, Pailhoriès, Hélène, additional, Lemarié, Carole, additional, Benmansour, Hanaa, additional, d’Humières, Camille, additional, Broutin, Lauranne, additional, Dauwalder, Olivier, additional, Levy, Michael, additional, Auger, Gabriel, additional, Kernéis, Solen, additional, Cattoir, Vincent, additional, Alviset, Sophie, additional, Armand-Lefèvre, Laurence, additional, Baldeyrou, Marion, additional, Becker, Agathe, additional, Boibieux, André, additional, Bonacorsi, Stéphane, additional, Burucoa, Christophe, additional, Cambau, Emmanuelle, additional, Casalegno, Jean-Sébastien, additional, Cointe, Aurélie, additional, Cremniter, Julie, additional, Destras, Grégory, additional, Duquaire, Paul, additional, Geslain, Guillaume, additional, Gustave, Claude-Alexandre, additional, Jacquier, Hervé, additional, Kouatchet, Achille, additional, Lecorche, Emmanuel, additional, Lejeune, Manon, additional, Lina, Bruno, additional, Mahieu, Rafaël, additional, Maamar, Adel, additional, Michaud, Anthony, additional, Monnard, Céline, additional, Montravers, Philippe, additional, Neuwirth, Catherine, additional, Péan de Ponfilly, Gauthier, additional, Pichon, Maxime, additional, Plouzeau, Chloé, additional, Poyart, Claire, additional, Quenot, Jean-Pierre, additional, Rzepecki, Vincent, additional, Stéphan, Robin, additional, Timsit, Jean-François, additional, Tran-Dinh, Alexy, additional, Vandenesch, François, additional, and Vigier, Emmanuelle, additional

Published
2021
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12. Additional file 1 of Multicenter evaluation of a syndromic rapid multiplex PCR test for early adaptation of antimicrobial therapy in adult patients with pneumonia

Author

Monard, Céline, Pehlivan, Jonathan, Auger, Gabriel, Alviset, Sophie, Dinh, Alexy Tran, Duquaire, Paul, Gastli, Nabil, D’Humières, Camille, Maamar, Adel, Boibieux, André, Baldeyrou, Marion, Loubinoux, Julien, Dauwalder, Olivier, Cattoir, Vincent, Armand-Lefèvre, Laurence, and Kernéis, Solen

Abstract

Additional file 1: Supplementary table 1. Microbiological documentation depending on the sample type (n=159). Supplementary table 2. Impact of the rm-PCR results on antibiotic prescription, according to the multidisciplinary committee and regarding sample type (n=159). Supplementary Table 3. Description of inadequate antibiotic regimen.

Published
2020
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14. Multicenter evaluation of a syndromic rapid multiplex PCR test for early adaptation of antimicrobial therapy in adult patients with pneumonia.

Author

Monard, Céline, Pehlivan, Jonathan, Auger, Gabriel, Alviset, Sophie, Tran Dinh, Alexy, Duquaire, Paul, Gastli, Nabil, d'Humières, Camille, Maamar, Adel, Boibieux, André, Baldeyrou, Marion, Loubinoux, Julien, Dauwalder, Olivier, Cattoir, Vincent, Armand-Lefèvre, Laurence, Kernéis, Solen, the ADAPT study group, Becker, Agathe, Charpentier, Julien, and Textoris, Julien

Subjects
PNEUMONIA, RESEARCH, TIME, RESEARCH methodology, ANTI-infective agents, RETROSPECTIVE studies, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, COMMUNITY-acquired infections, POLYMERASE chain reaction
Abstract

Background: Improving timeliness of pathogen identification is crucial to allow early adaptation of antibiotic therapy and improve prognosis in patients with pneumonia. We evaluated the relevance of a new syndromic rapid multiplex PCR test (rm-PCR) on respiratory samples to guide empirical antimicrobial therapy in adult patients with community-acquired pneumonia (CAP), hospital-acquired pneumonia (HAP), and ventilator-acquired pneumonia (VAP).Methods: This retrospective multicenter study was conducted in four French university hospitals. Respiratory samples were obtained from patients with clinical and radiological signs of pneumonia and simultaneously tested using conventional microbiological methods and the rm-PCR. A committee composed of an intensivist, a microbiologist, and an infectious diseases specialist retrospectively assessed all medical files and agreed on the most appropriate antimicrobial therapy for each pneumonia episode, according to the results of rm-PCR and blinded to the culture results. The rm-PCR-guided antimicrobial regimen was compared to the empirical treatment routinely administered to the patient in standard care.Results: We included 159 pneumonia episodes. Most patients were hospitalized in intensive care units (n = 129, 81%), and episodes were HAP (n = 68, 43%), CAP (n = 54, 34%), and VAP (n = 37, 23%). Conventional culture isolated ≥ 1 microorganism(s) at significant level in 95 (60%) patients. The syndromic rm-PCR detected at least one bacteria in 132 (83%) episodes. Based on the results of the rm-PCR, the multidisciplinary committee proposed a modification of the empirical therapy in 123 (77%) pneumonia episodes. The modification was a de-escalation in 63 (40%), an escalation in 35 (22%), and undetermined in 25 (16%) patients. In microbiologically documented episodes (n = 95), the rm-PCR increased appropriateness of the empirical therapy to 83 (87%), as compared to 73 (77%) in routine care.Conclusions: Use of a syndromic rm-PCR test has the potential to reduce unnecessary antimicrobial exposure and increase the appropriateness of empirical antibiotic therapy in adult patients with pneumonia. [ABSTRACT FROM AUTHOR]

Published
2020
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15. Impact of Sequential Culture Results on Diagnosis and De-Escalation of the Antibiotic Regimen in Joint and Bone Infections

Author

Kernéis, Solen, primary, Leprince, Cécile, additional, Archambeau, Denis, additional, Eyrolle, Luc, additional, Leclerc, Philippe, additional, Poupet, Hélène, additional, Loubinoux, Julien, additional, Gauzit, Rémy, additional, Salmon, Dominique, additional, Launay, Odile, additional, Poyart, Claire, additional, Anract, Philippe, additional, and Morand, Philippe C., additional

Published
2017
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16. The value of molecular techniques to diagnose Ureaplasma urealyticum and Nocardia farcinica pleuropneumonia in a patient with diffuse large B-cell lymphoma

Author

Canouï, Etienne, primary, Blanc, Kim, additional, Loubinoux, Julien, additional, Valade, Sandrine, additional, Hamard, Cécile, additional, Lefebvre, Aurélie, additional, Amorim, Sandy, additional, Bébéar, Cécile, additional, Rodriguez-Nava, Veronica, additional, Lebeaux, David, additional, Launay, Odile, additional, Alifano, Marco, additional, Rabbat, Antoine, additional, and Kernéis, Solen, additional

Published
2017
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23. Bacteremia Caused by Acinetobacter ursingii

Author

Loubinoux, Julien, primary, Mihaila-Amrouche, Liliana, additional, Le Fleche, Anne, additional, Pigne, Etienne, additional, Huchon, Gerard, additional, Grimont, Patrick A. D., additional, and Bouvet, Anne, additional

Published
2003
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27. Adult Invasive and Noninvasive Infections Due to Streptococcus dysgalactiaesubsp. equisimilisin France from 2006 to 2010

Author

Loubinoux, Julien, Plainvert, Céline, Collobert, Gislène, Touak, Gérald, Bouvet, Anne, and Poyart, Claire

Abstract

ABSTRACTWe characterized 182 Streptococcus dysgalactiaesubsp. equisimilisisolates and analyzed the epidemiological data on the corresponding infections. stG6, stG485, and stG6792were the 3 most prevalent invasive emmtypes among the 27 different emmtypes recovered. High rates of antimicrobial resistance were observed for macrolides (26.4%) and tetracycline (34.6%).

Published
2013
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28. Bacteremia Caused by a Strain ofDesulfovibrioRelated to the Provisionally NamedDesulfovibrio fairfieldensis

Author

Loubinoux, Julien, Mory, Francine, Pereira, Ines A. C., and Le Faou, Alain E.

Abstract

ABSTRACTEight isolates of Desulfovibriospp. have been obtained over 5 years from abdominal or brain abscesses or blood. In seven patients these strains were part of a mixed flora. One strain was isolated in pure culture from the blood of a patient with peritonitis of appendicular origin. According to the 16S rRNA gene sequences, this strain was close to Desulfovibrio fairfieldensis. The present report describes the fourth isolate of this recently described species to be isolated in pure culture or as a predominant part of the flora and to be associated with infectious processes. Thus, D. fairfieldensismay possess a higher pathogenic potential than other Desulfovibriospecies.

Published
2000
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29. Liste des collaborateurs

Author

Barbeyrac (de), Bertille, Barraud, Olivier, Bébéar, Cécile M., Bébéar, Christiane, Beraud, Laëtitia, Bingen, Édouard<ce:sup loc='post">†</ce:sup>, Bonacorsi, Stéphane, Bouchiat, Coralie, Buisson, Yves, Burucoa, Christophe, Cattoir, Vincent, Denis, François, Descours, Ghislaine, Drouet, Mireille, Dupieux, Céline, Durand, Géraldine, Essemilaire, Luc, Fenollar, Florence, Gaillot, Olivier, Garnier, Fabien, Guérin, François, Hidri, Nadia, Isnard, Christophe, Jarraud, Sophie, Jaulhac, Benoît, Jehl, François, Lambert, Thierry, Lanotte, Philippe, Lavigne, Jean-Philippe, Le Brun, Cécile, Le Hello, Simon, Lina, Gérard, Loubinoux, Julien, Mainardi, Jean-Luc, Mariani-Kurkdjian, Patricia, Martin, Christian, Martino (de), Sylvie, Mereghetti, Laurent, Mounier, Marcelle, O'Callaghan, David, Pereyre, Sabine, Pestourie, Nathalie, Peuchant, Olivia, Philippon, Alain, Piva, Claude, Plainvert, Céline, Ploy, Marie-Cécile, Poupet, Hélène, Poyart, Claire, Quentin, Roland, Ranc, Anne-Gaëlle, Ranger-Rogez, Sylvie, Riegel, Philippe, Tankovic, Jacques, Tazi, Asmaa, Van Belkum, Alex, and Vandenesch, François

Published
2016
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30. Value of Enterobacterial Repetitive Intergenic Consensus PCR for Study of Pasteurella multocidaStrains Isolated from Mouths of Dogs

Author

Loubinoux, Julien, Lozniewski, Alain, Lion, Christine, Garin, Daniel, Weber, Miche`le, and Le Faou, Alain E.

Abstract

ABSTRACTFifty-six Pasteurella multocidastrains (40 P. multocidasubsp. septicaand 16 P. multocidasubsp. multocidastrains) isolated from the mouths of 56 dogs among the 134 living in a French canine military training center (132e Groupe Cynophile de l’Arme´e de Terre, Suippes, France) were studied by use of enterobacterial repetitive intergenic consensus-PCR (ERIC-PCR) and restriction fragment length polymorphism (RFLP) techniques. Both techniques showed genomic heterogeneity of the strains studied. However, RFLP was more discriminatory than ERIC-PCR for differentiating P. multocidastrains. All but three pairs of strains were discriminated by RFLP, suggesting a limited circulation of strains between these dogs living in proximity. Although ERIC-PCR is easier and faster to perform, it cannot be recommended for epidemiological studies of P. multocidastrains.

Published
1999
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31. Clonal Spread of emmType 28 Isolates of Streptococcus pyogenesThat Are Multiresistant to Antibiotics

Author

Mihaila-Amrouche, Liliana, Bouvet, Anne, and Loubinoux, Julien

Abstract

ABSTRACTFifty-three pharyngitis-related and invasive isolates of Streptococcus pyogenesthat are resistant to bacitracin were collected. They were also resistant to streptomycin, kanamycin, macrolides, lincosamides, and streptogramin B. These multiresistant isolates were of emmtype 28 and clonally related as shown by pulsed-field gel electrophoresis.

Published
2004
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33. Epidemiological markers of group A streptococcal infections in France.

Author

Loubinoux J, Florent M, Merad B, Collobert G, and Bouvet A

Subjects
Base Sequence, DNA Primers, France epidemiology, Humans, Polymerase Chain Reaction, Prospective Studies, Streptococcal Infections microbiology, Streptococcal Infections epidemiology, Streptococcus pyogenes isolation & purification
Abstract

Background & Objectives: A limited number of biotypes, T-types, and emm-types have been found to be associated with invasive isolates of group A streptococci, confirming the involvement of the M protein in virulence and its importance as an epidemiological marker. In this study, the epidemiological markers in the clinical isolates of group A streptococci were compared in invasive and non invasive isolates., Methods: From 1998 to 2001, 141 invasive and 353 non invasive isolates in France were studied and their biotype, T-type, and emm-type were determined., Results: The invasive isolates were mostly obtained from blood whereas the non invasive isolates were isolated from throat. Most of the isolates were of biotype 1. The invasive isolates were mostly of the T-type 1 associated with emm-type 1. The T-type 4 associated with emm-type 4 and the T-type 28 associated with emm-type 28 were also frequent. Invasive isolates responsible for puerperal sepsis and non invasive isolates were mostly of the T-type 28 associated with emm-type 28., Interpretation & Conclusion: This study confirms the high prevalence of isolates of biotype 1, T-type 1, and emm-type 1 among invasive isolates of group A streptococci. The emm-type 28 associated with T-type 28 was frequently observed in non-invasive isolates. A prospective study is being conducted to update the prevalence of the different emm-types in France, which will be of importance for the development of future vaccines.

Published
2004

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