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5 results on '"Loos, B.G. (Bruno G.)"'

1. Translation of mouse model to human gives insights into periodontitis etiology

Author

Nashef, A. (Aysar), Matthias, M. (Munz), Weiss, E. (Ervin), Loos, B.G. (Bruno G.), Jepsen, S. (Søren), Velde, N. (Nathalie) van der, Uitterlinden, A.G. (André G), Wellmann, J. (Jürgen), Berger, K. (Klaus), Hoffmann, P. (Per), Laudes, M. (Matthias), Lieb, W. (Wolfgang), Franke, A. (Andre), Dommisch, H. (Henrik), Schäfer, A. (Arne), Houri-Haddad, Y. (Yael), Iraqi, F.A. (Fuad A.), Nashef, A. (Aysar), Matthias, M. (Munz), Weiss, E. (Ervin), Loos, B.G. (Bruno G.), Jepsen, S. (Søren), Velde, N. (Nathalie) van der, Uitterlinden, A.G. (André G), Wellmann, J. (Jürgen), Berger, K. (Klaus), Hoffmann, P. (Per), Laudes, M. (Matthias), Lieb, W. (Wolfgang), Franke, A. (Andre), Dommisch, H. (Henrik), Schäfer, A. (Arne), Houri-Haddad, Y. (Yael), and Iraqi, F.A. (Fuad A.)

Abstract

To suggest candidate genes involved in periodontitis, we combined gene expression data of periodontal biopsies from Collaborative Cross (CC) mouse lines, with previous reported quantitative trait loci (QTL) in mouse and with human genome-wide association studies (GWAS) associated with periodontitis. Periodontal samples from two susceptible, two resistant and two lines that showed bone formation after periodontal infection were collected during infection and naïve status. Differential expressed genes (DEGs) were analyzed in a case-control and case-only design. After infection, eleven protein-coding genes were significantly stronger expressed in resistant CC lines compared to susceptible ones. Of these, the most upregulated genes were MMP20 (P = 0.001), RSPO4 (P = 0.032), CALB1 (P = 1.06×10-4), and AMTN (P = 0.05). In addition, human orthologous of candidate genes were tested for their association in a case-controls samples of aggressive (AgP) and chronic (CP) periodontitis (5,095 cases, 9,908 controls). In this analysis, variants at two loci, TTLL11/PTGS1 (rs9695213, P = 5.77×10-5) and RNASE2 (rs2771342, P = 2.84×10-5) suggested association with both AgP and CP. In the association analysis with AgP only, the most significant associations were located at the HLA loci HLA-DQH1 (rs9271850, P = 2.52×10-14) and HLA-DPA1 (rs17214512, P = 5.14×10-5). This study demonstrates the utility of the CC RIL populations as a suitable model to investigate the mechanism of periodontal disease.

Published
2020
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2. Genome-wide association meta-analysis of coronary artery disease and periodontitis reveals a novel shared risk locus

Author

Munz, M. (Matthias), Richter, G.M. (Gesa M.), Loos, B.G. (Bruno G.), Jepsen, S. (Søren), Divaris, K. (Kimon), Offenbacher, S. (Steven), Teumer, A. (Alexander), Holtfreter, B. (Birte), Kocher, T. (Thomas), Bruckmann, C. (Corinna), Jockel-Schneider, Y. (Yvonne), Graetz, C. (Christian), Munoz, L. (Loreto), Bhandari, A. (Anita), Tennstedt, S. (Stephanie), Staufenbiel, I. (Ingmar), Velde, N. (Nathalie) van der, Uitterlinden, A.G. (André), de Groot, L.C.P.G.M. (Lisette C. P. G. M.), Wellmann, J. (Jürgen), Berger, K. (Klaus), Krone, B., Hoffmann, P. (Per), Laudes, M. (Matthias), Lieb, W. (Wolfgang), Franke, A. (Andre), Dommisch, H. (Henrik), Erdmann, J. (Jeanette), Schaefer, A. (Antje), Munz, M. (Matthias), Richter, G.M. (Gesa M.), Loos, B.G. (Bruno G.), Jepsen, S. (Søren), Divaris, K. (Kimon), Offenbacher, S. (Steven), Teumer, A. (Alexander), Holtfreter, B. (Birte), Kocher, T. (Thomas), Bruckmann, C. (Corinna), Jockel-Schneider, Y. (Yvonne), Graetz, C. (Christian), Munoz, L. (Loreto), Bhandari, A. (Anita), Tennstedt, S. (Stephanie), Staufenbiel, I. (Ingmar), Velde, N. (Nathalie) van der, Uitterlinden, A.G. (André), de Groot, L.C.P.G.M. (Lisette C. P. G. M.), Wellmann, J. (Jürgen), Berger, K. (Klaus), Krone, B., Hoffmann, P. (Per), Laudes, M. (Matthias), Lieb, W. (Wolfgang), Franke, A. (Andre), Dommisch, H. (Henrik), Erdmann, J. (Jeanette), and Schaefer, A. (Antje)

Abstract

Evidence for a shared genetic basis of association between coronary artery disease (CAD) and periodontitis (PD) exists. To explore the joint genetic basis, we performed a GWAS meta-analysis. In the discovery stage, we used a German aggressive periodontitis sample (AgP-Ger; 680 cases vs 3,973 co

Published
2018
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3. Corrigendum: A genome-wide association study identifies nucleotide variants at SIGLEC5 and DEFA1A3 as risk loci for periodontitis [Human Molecular Genetics., 26, 13, (2017) (2577-2588)]

Author

Munz, M. (Matthias), Willenborg, C. (Christina), Richter, G.M. (Gesa M.), Jockel-Schneider, Y. (Yvonne), Graetz, C. (Christian), Staufenbiel, I. (Ingmar), Wellmann, J. (Jürgen), Berger, K. (Klaus), Krone, B. (Bastian), Hoffmann, P. (Per), Velde, N. (Nathalie) van der, Uitterlinden, A.G. (André), de Groot, L.C.P.G.M. (Lisette C.P.G.M.), Sawalha, A.H. (Amr H.), Direskeneli, H. (Haner), Saruhan-Direskeneli, G. (Güher), Guzeldemir-Akcakanat, E. (Esra), Keceli, H.G. (Huseyin Gencay), Laudes, M. (Matthias), Noack, B. (Barbara), Teumer, A. (Alexander), Holtfreter, B. (Birte), Kocher, T. (Thomas), Eickholz, P. (Peter), Meyle, J. (Jörg), Doerfer, C. (Christof), Bruckmann, C. (Corinna), Lieb, W. (Wolfgang), Franke, A. (Andre), Schreiber, S. (Stefan), Nohutcu, R.M. (Rahime M.), Erdmann, J. (Jeanette), Loos, B.G. (Bruno G.), Jepsen, S. (Soeren), Dommisch, H. (Henrik), Schaefer, A. (Antje), Munz, M. (Matthias), Willenborg, C. (Christina), Richter, G.M. (Gesa M.), Jockel-Schneider, Y. (Yvonne), Graetz, C. (Christian), Staufenbiel, I. (Ingmar), Wellmann, J. (Jürgen), Berger, K. (Klaus), Krone, B. (Bastian), Hoffmann, P. (Per), Velde, N. (Nathalie) van der, Uitterlinden, A.G. (André), de Groot, L.C.P.G.M. (Lisette C.P.G.M.), Sawalha, A.H. (Amr H.), Direskeneli, H. (Haner), Saruhan-Direskeneli, G. (Güher), Guzeldemir-Akcakanat, E. (Esra), Keceli, H.G. (Huseyin Gencay), Laudes, M. (Matthias), Noack, B. (Barbara), Teumer, A. (Alexander), Holtfreter, B. (Birte), Kocher, T. (Thomas), Eickholz, P. (Peter), Meyle, J. (Jörg), Doerfer, C. (Christof), Bruckmann, C. (Corinna), Lieb, W. (Wolfgang), Franke, A. (Andre), Schreiber, S. (Stefan), Nohutcu, R.M. (Rahime M.), Erdmann, J. (Jeanette), Loos, B.G. (Bruno G.), Jepsen, S. (Soeren), Dommisch, H. (Henrik), and Schaefer, A. (Antje)

Abstract

The authors wish to apologize for the following two errors in the original article: (i) the first name of a co-author, Huseyin Gencay Keceli, was omitted; (ii) the statement 'This research was financially supported by the Turkish Scientific and Research Council (TUBITAK) (Grant no: 114S543)' was omitted. These have both now been corrected online.

Published
2018
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4. Human IgG2- and IgG4-expressing memory B cells display enhanced molecular and phenotypic signs of maturity and accumulate with age

Author

De Jong, B.G. (Britt G.), IJspeert, H. (Hanna), Marques, L. (Lemelinda), Burg, M. (Mirjam) van der, Dongen, J.J.M. (Jacques) van, Loos, B.G. (Bruno G.), Zelm, M.C. (Menno) van, De Jong, B.G. (Britt G.), IJspeert, H. (Hanna), Marques, L. (Lemelinda), Burg, M. (Mirjam) van der, Dongen, J.J.M. (Jacques) van, Loos, B.G. (Bruno G.), and Zelm, M.C. (Menno) van

Abstract

The mechanisms involved in sequential immunoglobulin G (IgG) class switching are still largely unknown. Sequential IG class switching is linked to higher levels of somatic hypermutation (SHM) in vivo, but it remains unclear if these are generated temporally during an immune response or upon activation in a secondary response. We here aimed to uncouple these processes and to distinguish memory B cells from primary and secondary immune responses. SHM levels and IgG subclasses were studied with 454 pyrosequencing on blood mononuclear cells from young children and adults as models for primary and secondary immunological memory. Additional sequencing and detailed immunophenotyping with IgG subclass-specific antibodies was performed on purified IgG+ memory B-cell subsets. In both children and adults, SHM levels were higher in transcripts involving more downstream-located IGHG genes (esp. IGHG2 and IGHG4). In adults, SHM levels were significantly higher than in children, and downstream IGHG genes were more frequently utilized. This was associated with increased frequencies of CD27+ IgG+ memory B cells, which contained higher levels of SHM, more IGHG2 usage, and higher expression levels of activation markers than CD27-IgG+ memory B cells. We conclude that secondary immunological memory accumulates with age and these memory B cells express CD27, high levels of activation markers, and carry high SHM levels and frequent usage of IGHG2. These new insights contribute to our understanding of sequential IgG subclass switching and show a potential relevance of using serum IgG2 levels or numbers of IgG2-expressing B cells as markers for efficient generation of memory responses.

Published
2017
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5. Highly specific protease-based approach for detection of porphyromonas gingivalis in diagnosis of periodontitis

Author

Hays, J.P. (John), Kaman, W.E. (Wendy), Galassi, F. (Fabiano), Soet, J.J. (Johannes) de, Bizzarro, S. (Sergio), Loos, B.G. (Bruno G.), Veerman, E.C.I. (Enno), Belkum, A.F. (Alex) van, Bikkerk, F.J., Hays, J.P. (John), Kaman, W.E. (Wendy), Galassi, F. (Fabiano), Soet, J.J. (Johannes) de, Bizzarro, S. (Sergio), Loos, B.G. (Bruno G.), Veerman, E.C.I. (Enno), Belkum, A.F. (Alex) van, and Bikkerk, F.J.

Abstract

Porphyromonas gingivalis is associated with the development of periodontitis. Here we describe the development of a highly specific protease-ba

Published
2012
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