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403 results on '"Loglio, G."'

17. Interfacial dynamics of adsorption layers as support of biomedical research and diagnostics

Author

Santini, E., Nepita, I., Bykov, A. G., Ravera, F., Liggieri, L., Dowlati, S., (0000-0002-9881-7304) Javadi, A., Miller, R., Loglio, G., Santini, E., Nepita, I., Bykov, A. G., Ravera, F., Liggieri, L., Dowlati, S., (0000-0002-9881-7304) Javadi, A., Miller, R., and Loglio, G.

Abstract

The input of chemical and physical sciences to life sciences is increasingly important. Surface science as a complex multidisciplinary research area provides many relevant practical tools to support for example research in medicine. Tensiometry and surface rheology of human biological liquid as diagnostic tool is very successfully applied. Also for the characterization of pulmonary surfactants, this methodology is essential to deepen the insight into the functionality of lungs and the most efficient administration of drugs. Problems in ophthalmology can be addressed by surface science methods, such as the stability of wetting films and the development of artificial tears. The serious problem of obesity is a fast developing disease in many industrial countries and must be better understood and therapies for its treatment developed. Finally, the application of fullerenes as a suitable system for detecting cancer in humans is discussed.

Published
2022

21. Methods and models to investigate the physicochemical functionality of pulmonary surfactant

Author

Ravera, F., Miller, R., Zuo, Y. Y., Noskov A., B., Bykov G., A., Volodymyr I., K., Loglio, G., (0000-0002-9881-7304) Javadi, A., Liggieri, L., Ravera, F., Miller, R., Zuo, Y. Y., Noskov A., B., Bykov G., A., Volodymyr I., K., Loglio, G., (0000-0002-9881-7304) Javadi, A., and Liggieri, L.

Abstract

The pulmonary surfactant (PS) is a complex mixture of lipids and proteins dispersed in the aqueous lining layer of the alveolar surface. Such a layer plays a key role in maintaining the proper lung functionality. It acts as a barrier against inhaled particles and pathogens, including viruses, and may represent an important entry point for drugs delivered via aerosols. Understanding the physicochemical properties of PS is therefore of importance for the comprehension of pathophysiological mechanisms affecting the respiratory system. That can be of particular relevance for supporting the development of novel therapeutic interventions against COVID-19–induced acute respiratory distress syndrome. Owing to the complexity of the in vivo alveolar lining layer, several in vitro methodologies have been developed to investigate the functional and structural properties of PS films or interfacial films made by major constituents of the natural PS. As breathing is a highly dynamic interfacial process, most applied methodologies for studying PSs need to be capable of dynamic measurements, including the study of interfacial dilational rheology. We provide here a review of the most frequently and successfully applied methodologies that have proven to be excellent tools for understanding the biophysics of the PS and of its role in the respiratory mechanics. This overview also discusses recent findings on the dynamics of PS layers and the impact of inhalable particles or pathogens, such as the novel coronavirus, on its functionality.

Published
2021

28. Dilational viscoelasticity of polyelectolyte/surfactant adsorption films at the air/water interface: Dodecyltrimethylammonium bromide and sodium poly(styrenesulfonate)

Author

Noskov, B.A., Loglio, G., and Miller, R.

Subjects
Viscoelastic materials -- Research, Polyelectrolytes -- Research, Chemicals, plastics and rubber industries
Abstract

The dynamic surface elasticity of mixed aqueous poly(styrenesulfonate)/alkyltrimethylammonium bromide solutions is measured by the oscillating barrier, oscillating drop, and capillary wave methods as a function of time and surfactant concentration. It was found that at low surfactant concentrations (less than 0.3 mM) the surface viscoelastic behavior is close to that of relatively concentrated pure PSS solutions.

Published
2004

49. Dynamics of Interfacial Layer Formation

Author

Javadi A., Kraegel J., Kovalchuk V. I., Liggieri L., Loglio G., Aksenenko E.V., Fainerman V.B., and Miller R.

Subjects
Computational Methods
Published
2016

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