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3 results on '"Loghman Diojan"'

1. Transfer of Radio-Adaptation via Serum: A Preliminary Report

Author

Ehsan Khodamoradi, Rasool Azmoonfar, Mohammad Mohammadi, Amir Kiani, Abbas Haghparast, Nasrin Sharafi, and Loghman Diojan

Subjects
adaptive response, radiation effects, serum, survival rate, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Introduction: Adaptive response is one of the important concepts in radiobiology. The present report aimed to transfer the radio-adaptation via serum. Material and Methods: In total, 50 male adult Wistar rats were randomly divided into 6 groups, including control, serum control, low-dose (100cGy), low-dose/lethal, serum/lethal, and lethal (8Gy). Exposure was carried out by a linear accelerator (Elekta Synergy® Platform) with a 40×40cm field size. The animals were monitored in terms of the endpoints of the survival rate, and at the first stage, the rats were exposed to the low doses of radiation. Subsequently, the serum was injected intraperitoneally under sterile conditions 6 h after low-dose exposure. The Kaplan Meier Survival Curve was used to evaluate the survival rate (PResults: There was a significant difference among different groups regarding the survival rates. Moreover, a statistically significant difference was observed between low-dose/lethal and low-dose/serum, low-dose/lethal and lethal, and low-dose/serum and lethal (P=0.001). Similarly, there was a statistically significant difference between the control and experimental groups regarding the survival rates (P=0.001). Conclusion: To the best of our knowledge, this method can lead to immunological responses or unknown mechanisms that result in the increased survival adaptive response to subsequent high-dose radiation.

Published
2020
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2. Radioprotective Mechanisms of Arbutin: A Systematic Review

Author

Shima Sadeghinezhad, Ehsan Khodamoradi, Loghman Diojan, Shahram Taeb, and Masoud Najafi

Subjects
Psychiatry and Mental health, Oxidative Stress, Radiation Protection, Arbutin, Humans, Apoptosis, Radiation-Protective Agents
Abstract

Purpose: Efforts to produce radioprotective agents of high potential are appropriate strategies for overcoming possible IR toxicity in organisms. The present research aims to evaluate the signaling pathways and mechanisms through which arbutin exerts radioprotective effects on organisms. Methods: The databases of PubMed, Web of Sciences, Google Scholar, and Scopus were searched to find studies that reported radioprotective effects for arbutin. Besides, the data were searched within the time period from 2010 to 2020. Result: Five research articles met our criteria, which were included in the analysis based on their relevance to the topic. The present systematic review provides conclusions about various mechanisms and pathways through which arbutin induces radioprotection. Conclusions: Based on the relevant studies, various mechanisms can be proposed for inducing radioprotective effects by arbutin, including inhibition of oxidative stress, apoptosis, and inflammation.

Published
2021

3. Effect of Pentoxifylline on Staurosporine-Induced Neurite Elongation in PC12 Cells

Author

Ali Bidmeshkipour, Ehsan Khodamoradi, Loghman Diojan, Mehri Azadbakht, and Hossein Zhaleh

Subjects
0301 basic medicine, Programmed cell death, Neurite, Cell Survival, Phosphodiesterase Inhibitors, Immunocytochemistry, Neurite elongation, PC12 Cells, Pentoxifylline, Andrology, 03 medical and health sciences, 0302 clinical medicine, Neurites, medicine, Animals, Humans, Staurosporine, Viability assay, Enzyme Inhibitors, Chemistry, Cell growth, Cell Differentiation, Mesenchymal Stem Cells, General Medicine, Rats, cell death, 030104 developmental biology, 030220 oncology & carcinogenesis, Signal Transduction, Research Article, medicine.drug
Abstract

Objective: Pentoxifylline enhances neurite elongation in PC12 cells. This study investigated the effects of pentoxifylline on staurosporine-induced neurite elongation in PC12 cells. Materials and Methods: There were five treatment groups, including treatment group I (1 nM), treatment group II (10 nM), treatment group III (100 nM), treatment group IV (1uM), and treatment group V (10 mM of pentoxifylline), together with 214 nM staurosporine for a range of time (6, 12 and 24 hours). Cells only treated with staurosporine at a concentration of 214 nM were used as the control group. Cell proliferation, cell death, immunocytochemistry assay, and Total Neurite Length were assessed. Results: The results showed that pentoxifylline increased cell viability (p

Published
2019

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