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Effect of Pentoxifylline on Staurosporine-Induced Neurite Elongation in PC12 Cells
- Source :
- Asian Pacific Journal of Cancer Prevention : APJCP
- Publication Year :
- 2019
- Publisher :
- EpiSmart Science Vector Ltd, 2019.
-
Abstract
- Objective: Pentoxifylline enhances neurite elongation in PC12 cells. This study investigated the effects of pentoxifylline on staurosporine-induced neurite elongation in PC12 cells. Materials and Methods: There were five treatment groups, including treatment group I (1 nM), treatment group II (10 nM), treatment group III (100 nM), treatment group IV (1uM), and treatment group V (10 mM of pentoxifylline), together with 214 nM staurosporine for a range of time (6, 12 and 24 hours). Cells only treated with staurosporine at a concentration of 214 nM were used as the control group. Cell proliferation, cell death, immunocytochemistry assay, and Total Neurite Length were assessed. Results: The results showed that pentoxifylline increased cell viability (p
- Subjects :
- 0301 basic medicine
Programmed cell death
Neurite
Cell Survival
Phosphodiesterase Inhibitors
Immunocytochemistry
Neurite elongation
PC12 Cells
Pentoxifylline
Andrology
03 medical and health sciences
0302 clinical medicine
Neurites
medicine
Animals
Humans
Staurosporine
Viability assay
Enzyme Inhibitors
Chemistry
Cell growth
Cell Differentiation
Mesenchymal Stem Cells
General Medicine
Rats
cell death
030104 developmental biology
030220 oncology & carcinogenesis
Signal Transduction
Research Article
medicine.drug
Subjects
Details
- ISSN :
- 2476762X
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Asian Pacific Journal of Cancer Prevention
- Accession number :
- edsair.doi.dedup.....adaa01b4606a6986462d37bc3c24937e