114 results on '"Liying Peng"'
Search Results
2. The effects of Tripterygium wilfordii Hook F on renal outcomes in type 2 diabetic kidney disease patients with severe proteinuria: a single-center cohort study
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Yaqi Cheng, Yuhao Liu, Liling Lin, Danni Li, Liying Peng, Ke Zheng, Jianling Tao, and Mingxi Li
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Tripterygium wilfordii Hook F ,diabetic kidney disease ,proteinuria ,renal outcomes ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Aim Tripterygium wilfordii Hook F (TwHF) has been shown to substantially reduce proteinuria in patients with diabetic kidney disease (DKD); however, the effect of TwHF on renal outcomes in DKD remains unknown. Accordingly, we aimed to establish the effects of TwHF on renal outcomes in patients with DKD.Methods Overall, 124 patients with DKD, induced by type 2 diabetes mellitus, with 24-h proteinuria > 2 g, and an estimated glomerular filtration rate > 30 mL/min/1.73 m2 were retrospectively investigated. The renal outcomes were defined as doubling serum creatinine levels or end-stage kidney disease. Kaplan-Meier curves and Cox regression analyses were performed to analyze prognostic factors for renal outcomes.Results By the end of the follow-up, renal outcomes were observed in 23 and 11 patients in the non-TwHF and TwHF groups, respectively (p = 0.006). TwHF significantly reduced the risk of renal outcomes (adjusted hazard ratio [HR] 0.271, 95% confidence interval [CI] 0.111–0.660, p = 0.004) in patients with chronic kidney disease (CKD) G3 (adjusted HR 0.274, 95%CI 0.081–0.932, p = 0.039). Based on the Kaplan-Meier analysis, 1- and 3-year proportions of patients without renal outcomes were significantly lower in the non-TwHF group than those in the TwHF group (92.8% vs. 95.5% and 47.2% vs. 76.8%, respectively; p = 0.0018).Conclusion In DKD patients with severe proteinuria, TwHF could prevent DKD progression, especially in patients with CKD G3. A randomized clinical trial is needed to elucidate the benefits of TwHF on renal outcomes in patients with DKD.
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- 2024
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3. Spatial distribution and environmental/biological co-regulation mechanism of dimethyl sulfur compounds in the eastern Indian Ocean
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Liying Peng, Chenjuan Fan, Yu Guo, Changling Ding, Xingzhou Wang, Guicheng Zhang, and Jun Sun
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the eastern Indian Ocean ,dimethyl sulfur compounds ,co-regulation mechanism ,spatial distribution ,picophytoplankton ,Science ,General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
Dimethyl sulfur compounds including dimethylsulfoniopropionate (DMSP), dimethyl sulfide (DMS), and dimethyl sulfoxide (DMSO), play a crucial part in global sulfur cycling. The eastern Indian Ocean (EIO), characterized by its remarkable diversity of biomes and climate dynamics, is integral to global climate regulation. However, the regulation mechanism of DMS (P, O) in the EIO remains to be elucidated in detail. This paper presented a field survey aimed at investigating the spatial distribution of DMS (P, O) and their relationships with environmental and biological factors in the EIO. The surface concentrations of DMS, DMSPt, and DMSOt varied from 0.07 to 7.37 nmol/L, 0.14 to 9.17 nmol/L, and 0.15 to 3.32 nmol/L, respectively, and their distributions are attributed to high Chl-a concentration near Sri Lanka and the influence of ocean currents (Wyrtki jets, Bay of Bengal runoff). Higher concentrations of DMS (P) and DMSOt were predominantly observed in water columns shallower than 75m and deeper than 75m deep, respectively. The monthly DMS fluxes in the study area peaked in August. Temperature and Dissolved Silica Index (DSI) were the key environmental determinants for DMS distribution, while nitrate (NO3-) was the primary factor for both DMSPt and DMSOt. In terms of biological factors, Prochlorococcus and Synechococcus were significant contributors to DMS (P, O) dynamics. Synechococcus was the dominant influence on the DMS source and DMSPt sink, whereas Prochlorococcus primarily consumed DMSOt. Furthermore, the structural equation modeling (SEM) revealed the relationship between DMS, DMSPt, DMSOt, and the key environmental/biological factors, as well as among them, and together they formed a co-regulatory network in the EIO. This contributes significantly to the advancement of global ecosystem models for DMS (P, O).
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- 2024
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4. Effects of ultra‐high‐temperature processes on metabolite changes in milk
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Ge Bai, Long Cheng, Liying Peng, Bin Wu, Yuguo Zhen, Guixin Qin, Xuefeng Zhang, Natnael D. Aschalew, Zhe Sun, and Tao Wang
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gas chromatography–mass spectrometry ,metabolites ,milk ,ultra‐high‐temperature sterilized ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Abstract Processing can affect milk properties and alter the composition of milk metabolites, which has corresponding effects on milk flavor and quality. It is quite important to study the safe quality control of milk processing. Therefore, the purpose of this study was to identify metabolites at different steps of ultra‐high‐temperature‐sterilized (UHT) milk processing using gas chromatography–mass spectrometry (GC–MS). These steps included raw milk, pasteurized milk (80°C for 15 s), semi‐finished milk (after pasteurizing, it was homogenized at 75°C with pressure of 250 bar), UHT milk (at 140°C for 10 s), and finished milk (homogenized UHT milk). A total of 66 metabolites were identified across all samples, including 30 metabolites in the chloroform layers of the milk samples and 41 metabolites in the water layers; 5 metabolites were found in both layers. The metabolites were primarily fatty acids, amino acids, sugars, and organic acids. For example, pasteurized and ultra‐high‐temperature‐sterilized kinds of milk had lactose contents similar to those of raw milk, with increases in saturated fatty acids such as hexadecanoic acid and octadecanoic acid. Additionally, these findings indicated that these methods of processing can affect the contents of some components of milk. Therefore, from the perspective of milk's nutritional value and consumer health, the excessive heating of dairy products should be avoided and the milk heat treatment process should be standardized from the source.
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- 2023
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5. Engineered Fabrication of Enamel-Mimetic Materials
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Lingyun Zhang, Yunfan Zhang, Tingting Yu, Liying Peng, Qiannan Sun, and Bing Han
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Regeneration ,Remineralization ,Abiotic enamel ,Biomimetic ,Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
Tooth enamel, which is a biological tissue mainly composed of well-aligned hydroxyapatite nanocrystals and an interlaced protein matrix, has remarkable mechanical and aesthetic behaviors. Nevertheless, it is challenging to regenerate enamel naturally, and potential pulp involvement and tooth loss may occur. As the hardest biogenic composite material, enamel has long been regarded as a promising load-bearing material. Thus, understanding the enamel formation process and enamel structural motif mechanisms is important for the design and engineering of high-performance biomimetic composites with high strength and physical resilience. Extensive studies have been conducted on mimicking the microstructure and mechanical properties of tooth enamel, and various enamel-like material synthesis protocols have been developed. In light of the engineering fabrication of enamel-like materials, this review focuses on recent progress in synthetic strategies for enamel-mimetic materials and provides a discussion of the potential applications of these materials.
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- 2022
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6. Do intravitreal anti-vascular endothelial growth factor agents lead to renal adverse events? A pharmacovigilance real-world study
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Lin Jiang, Liying Peng, Yangzhong Zhou, Gang Chen, Bin Zhao, Mingxi Li, and Xuemei Li
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acute kidney injury ,vascular endothelial growth factor ,adverse event reporting system ,pharmacovigilance ,ophthalmic medicine ,Medicine (General) ,R5-920 - Abstract
PurposeIntravitreal vascular endothelial growth factor (VEGF) blockade is essential in many macular edema diseases treatment. However, intravitreal VEGF treatment has been reported to lead to deteriorated proteinuria and renal function. This study aimed to explore the relationship between renal adverse events (AEs) and the intravitreal use of VEGF inhibitors.MethodIn the FDA’s Adverse Event Reporting System (FAERS) database, we searched for renal AEs of patients receiving various anti-VEGF drugs. We performed statistics on renal AEs in patients treated with Aflibercept, Bevacizumab, Ranibizumab, and Brolucizumab (from January 2004 to September 2022) using disproportionate and Bayesian analysis. We also investigated the time to onset, fatality, and hospitalization rates of renal AEs.ResultsWe identified 80 reports. Renal AEs were most frequently associated with Ranibizumab (46.25%) and Aflibercept (42.50%). However, the association between intravitreal anti-VEGFs and renal AEs was insignificant since the reporting odds ratio of Aflibercept, Bevacizumab, Ranibizumab, and Brolucizumab were 0.23 (0.16, 0.32), 0.24 (0.11, 0.49), 0.37 (0.27, 0.51) and 0.15 (0.04, 0.61), respectively. The median time to renal AEs onsets was 37.5 (interquartile range 11.0–107.3) days. The hospitalization and fatality rates in patients who developed renal AEs were 40.24 and 9.76%, respectively.ConclusionThere are no clear signals for the risk of renal AEs following various intravitreal anti-VEGF drugs based on FARES data.
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- 2023
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7. Hyper-Realistic Rendering of Endoleak and Common Iliac Artery Occlusion
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Baolei Guo and Liying Peng
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 ,Surgery ,RD1-811 - Published
- 2023
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8. Clinical efficacy of tacrolimus in systemic lupus erythematosus with various manifestations: a real-world study
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Wei Bai, Mengtao Li, Shuang Zhou, Liying Peng, Jiuliang Zhao, Xinping Tian, Qian Wang, Xiaomei Leng, Shangzhu Zhang, Yanhong Wang, Yan Zhao, Xiaofeng Zeng, and Lishao Guo
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Medicine - Published
- 2022
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9. Morphological changes of the anterior alveolar bone due to retraction of anterior teeth: a retrospective study
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Qiannan Sun, Wenhsuan Lu, Yunfan Zhang, Liying Peng, Si Chen, and Bing Han
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Alveolar bone morphology ,Incisor retraction ,Orthodontic extraction treatment ,Point A ,Point B ,Specialties of internal medicine ,RC581-951 - Abstract
Abstract Backgroud To analyze the morphological changes of the anterior alveolar bone after the retraction of incisors in premolar extraction cases and the relationship between incisor retraction and remodeling of the alveolar base represented by points A and B displacements. Methods Pre- (T0) and post-treatment (T1) lateral cephalograms of 308 subjects in the maxilla and 154 subjects in the mandible who underwent the orthodontic treatment with extraction of 2 premolars in upper or lower arches were included. Alveolar bone width and height in both the maxillary and mandible incisor area were measured at T0 and T1 respectively. By superimposing the T0 and T1 cephalometric tracings, changes of points A and B, and the movement of the incisors were also measured. Then the correlation between incisor movement and the displacements of points A and B was analyzed. Results The alveolar bone width (ABW) showed a significant decrease in both maxilla and mandible (P 0.05). The alveolar bone height (ABH) showed a significant increase in the labial side of maxilla and a significant decrease in the lingual side of maxilla and mandible. A strong positive correlation was verified between incisor movement and position changes of points A and B in both horizontal and vertical directions. Conclusions Anterior alveolar bone width and height generally decreased after orthodontic treatment. Incisor retraction led to significant position changes of points A and B. The decrease of anterior alveolar bone due to significant incisor retraction should be taken into account in treatment planning.
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- 2021
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10. Study on the seasonal variations of dimethyl sulfide, its precursors and their impact factors in the Bohai Sea and North Yellow Sea
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Yu Guo, Liying Peng, Zishi Liu, Xiaoting Fu, Guicheng Zhang, Ting Gu, Danyang Li, and Jun Sun
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dimethyl sulfide ,the Bohai Sea and North Yellow Sea ,BAPI-PIMS ,the key impact factors ,seasonal variations ,Science ,General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
Dimethyl sulfide (DMS) is one of the most important volatile biogenic sulfur compounds and plays a significant role in global climate change. Studying the seasonal variations and the environmental factors that affect the concentration of DMS would aid in understanding the biogeochemical cycle of sulfur compounds. Using benzene-assisted photoionization positive ion mobility spectrometry (BAPI-PIMS), the seasonal distribution and the key impact factors of DMS and dimethylsulfoniopropionate (DMSP) in the Bohai Sea and North Yellow Sea were investigated in the summer and autumn of 2019. The concentrations of DMS and its precursors, DMSPp and DMSPd, in the surface seawater were 0.11–23.90, 0.67–41.38, and 0.03–12.28 nmol/L, respectively, in summer, and 0.10–20.79, 0.39–13.51, and 0.18–20.58 nmol/L, respectively, in autumn. The air-to-sea exchange flux of DMS was 43.05 ± 44.52 and 34.06 ± 63.38 μmol/(m·d), respectively, in summer and autumn. The results demonstrated that the temperature was the most dominant environmental factor, and the abundance of dinoflagellates was the most dominant biological factor that affected the distribution of DMS and DMSP in summer. The abundance of diatoms was the most dominant biological factor, and the levels of PO43-, NO2-, NO3-, and SiO32- were the dominant environmental factors that affected the distribution of DMS and DMSP in autumn. These results of this study would be of great significance in understanding the biochemical cycle of DMS in BS and NYS.
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- 2022
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11. Accuracy of additive manufacturing in stomatology
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Yao Tang, Yunfan Zhang, Zhaoqiang Meng, Qiannan Sun, Liying Peng, Lingyun Zhang, Wenhsuan Lu, Wei Liang, Gui Chen, and Yan Wei
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three-dimensional (3D) printing ,digital manufacturing ,dentistry ,maxillofacial surgery ,precision ,trueness ,Biotechnology ,TP248.13-248.65 - Abstract
With the rapid development of the three-dimensional (3D) printing technology in recent decades, precise and personalized manufacturing has been achieved gradually, bringing benefit to biomedical application, especially stomatology clinical practice. So far, 3D printing has been widely applied to prosthodontics, orthodontics, and maxillofacial surgery procedures, realizing accurate, efficient operation processes and promising treatment outcomes. Although the printing accuracy has improved, further exploration is still needed. Herein, we summarized the various additive manufacturing techniques and their applications in dentistry while highlighting the importance of accuracy (precision and trueness).
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- 2022
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12. Sirolimus versus tacrolimus for systemic lupus erythematosus treatment: results from a real-world CSTAR cohort study
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Xiaofeng Zeng, Qian Wang, Jiuliang Zhao, Xinping Tian, Hongbin Li, Mengtao Li, Yan Zhao, Hui Luo, Yanhong Wang, Xiaofeng Li, Pingting Yang, Xinwang Duan, Yongfei Fang, Hongfeng Zhang, Liying Peng, and Chanyuan Wu
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Immunologic diseases. Allergy ,RC581-607 - Abstract
Objective The effectiveness and safety of sirolimus for SLE treatment have been shown in some uncontrolled studies. However, a comparison of sirolimus with other classic immunosuppressants has not been reported. We conducted the study to compare the effectiveness and safety of sirolimus versus tacrolimus for SLE treatment.Methods A real-world cohort study was conducted. Patients with clinically active SLE who were prescribed sirolimus or tacrolimus were enrolled. Propensity score matching was used to ensure equivalent disease conditions and background medications. SLE disease activity indices, serological parameters, steroid doses, modification of other immunosuppressants, renal effectiveness and adverse events were compared between the two groups at 3-month, 6-month, 9-month and 12-month follow-up visits.Results Data from 52 patients in each of the sirolimus and tacrolimus groups were analysed. Indices regarding the effectiveness of sirolimus, including Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) scores, physician’s global assessment (PhGA) scores, and proportion of patients with SLEDAI-2K reduction of ≥4 and PhGA increase of
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- 2022
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13. FIP-fve Stimulates Cell Proliferation and Enhances IL-2 Release by Activating MAP2K3/p38α (MAPK14) Signaling Pathway in Jurkat E6-1 Cells
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Kefei Gu, Tan Wang, Liying Peng, and Yueliang Zhao
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FIP-fve ,immunomodulation mechanism ,proteomics analysis ,MAP2K3/p38α ,IL-2 ,Nutrition. Foods and food supply ,TX341-641 - Abstract
FIP-fve, a fungal fruiting body protein from Flammulina velutipes, has potential immunomodulatory properties. Here, we investigated the immunomodulation mechanism of FIP-fve in Jurkat E6-1 cells by conducting a cell viability assay and IL-2 release assay. Kinase inhibitors experiment and proteomics analysis were also involved in the mechanism study. It was found that FIP-fve stimulated cell proliferation and enhanced IL-2 secretion in a dose-dependent manner in Jurkat E6-1 cells. Unbiased high-throughput proteomics analysis showed that 4 T cell immune activation markers, including ZAP-70, CD69, CD82, and KIF23, were upregulated in response to FIP-fve treatment. Further pathway analysis indicated that MAP2K3/p38 pathway-related proteins, including MAP2K, p38, ELK, AATF, FOS, and JUN-B, were unregulated. In addition, losmapimod (p38 inhibitor) and gossypetin (MAP2K3 inhibitor) inhibited FIP-fve enhanced cell proliferation and IL-2 release in Jurkat E6-1 cells. Our results demonstrate that FIP-fve stimulates cell proliferation and enhances IL-2 secretion through MAP2K3/p38α activation.
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- 2022
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14. Fine mapping of a candidate gene for cool-temperature-induced albinism in ornamental kale
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Chenghuan Yan, Liying Peng, Lei Zhang, and Zhengming Qiu
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Albino trait ,Semi-dominant inheritance ,BSR-seq ,Cytochrome P450 gene ,Ornamental kale ,Botany ,QK1-989 - Abstract
Abstract Background The symptoms of cool-temperature-induced chlorosis (CTIC) are widely existed in higher plants. Although many studies have shown that the genetic mechanism of CTIC is generally controlled by recessive genes in model plants, the dominant inheritance of albinism has not been reported thus far. Here, two CTIC mutants, Red Kamome and White Kamome, were utilized to analyse the inheritance of the albino trait in ornamental kale. The objective of this investigation is to fine-map the target locus and identify the most likely candidate genes for albinism. Results Genetic analysis revealed that the albinism in the inner leaves of ornamental kale followed semi-dominant inheritance and was controlled by a single locus in two segregating populations. BSR-seq in combination with linkage analysis was employed to fine-map the causal gene, named AK (Albino Kale), to an approximate 60 kb interval on chromosome C03. Transcriptome data from two extreme pools indicated that the differentially expressed gene of Bol015404, which encodes a cytochrome P450 protein, was the candidate gene. The Bol015404 gene was demonstrated to be upregulated in the albino leaves of ornamental kale by qPCR. Additionally, the critical temperature for the albinism was determined between 10 °C and 16 °C by gradient test. Conclusions Using two independent segregating populations, the albino mutants were shown to be controlled by one semi-dominant gene, AK, in ornamental kale. The Bol015404 gene was co-segregated with albinism phenotypes, suggesting this unknown function P450 gene as the most likely candidate gene. The albino trait appeared caused by the low temperatures rather than photoperiod. Our results lay a solid foundation on the genetic control of albinism in ornamental kale.
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- 2020
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15. Ceramic Toughening Strategies for Biomedical Applications
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Rushui Bai, Qiannan Sun, Ying He, Liying Peng, Yunfan Zhang, Lingyun Zhang, Wenhsuan Lu, Jingjing Deng, Zimeng Zhuang, Tingting Yu, and Yan Wei
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ceramic ,biomedical ,fracture ,toughening ,reinforcing phase ,surface modification ,Biotechnology ,TP248.13-248.65 - Abstract
Aiming at shortage of metal materials, ceramic is increasingly applied in biomedicine due to its high strength, pleasing esthetics and good biocompatibility, especially for dental restorations and implants, artificial joints, as well as synthetic bone substitutes. However, the inherent brittleness of ceramic could lead to serious complications, such as fracture and disfunction of biomedical devices, which impede their clinical applications. Herein, several toughening strategies have been summarized in this review, including reinforcing phase addition, surface modification, and manufacturing processes improvement. Doping metal and/or non-metal reinforcing fillers modifies toughness of bulk ceramic, while surface modifications, mainly coating, chemical and thermal methods, regulate toughness on the surface layer. During fabrication, optimization should be practiced in powder preparation, green forming and densification processes. Various toughening strategies utilize mechanisms involving fine-grained, stress-induced phase transformation, and microcrack toughening, as well as crack deflection, bifurcation, bridging and pull-out. This review hopes to shed light on systematic combination of different toughening strategies and mechanisms to drive progress in biomedical devices.
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- 2022
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16. Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis
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Xiaowei Zhang, Ping Zhang, Lin An, Ningyuan Sun, Liying Peng, Weiwei Tang, Dingyuan Ma, and Jun Chen
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Miltirone ,Hepatocellular carcinoma ,Pyroptosis ,GSDME ,Cell death ,HepG2 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Pyroptosis is a form of programmed cell death, and recently described as a new molecular mechanism of chemotherapy drugs in the treatment of tumors. Miltirone, a derivative of phenanthrene-quinone isolated from the root of Salvia miltiorrhiza Bunge, has been shown to possess anti-cancer activities. Here, we found that miltirone inhibited the cell viability of either HepG2 or Hepa1-6 cells, and induced the proteolytic cleavage of gasdermin E (GSDME) in each hepatocellular carcinoma (HCC) cell line, with concomitant cleavage of caspase 3. Knocking out GSDME switched miltirone-induced cell death from pyroptosis to apoptosis. Additionally, the induction effects of miltirone on GSDME-dependent pyroptosis were attenuated by siRNA-mediated caspase three silencing and the specific caspase three inhibitor Z-DEVD-FMK, respectively. Miltirone effectively elicited intracellular accumulation of reactive oxygen species (ROS), and suppressed phosphorylation of mitogen-activated and extracellular signal-regulated kinase (MEK) and extracellular regulated protein kinases 1/2 (ERK1/2) for pyroptosis induction. Moreover, miltirone significantly inhibited tumor growth and induced pyroptosis in the Hepa1-6 mouse HCC syngeneic model. These results provide a new insight that miltirone is a potential therapeutic agent for the treatment of HCC via GSDME-dependent pyroptosis.
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- 2020
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17. Longitudinal Prediction of Infant MR Images With Multi-Contrast Perceptual Adversarial Learning
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Liying Peng, Lanfen Lin, Yusen Lin, Yen-wei Chen, Zhanhao Mo, Roza M. Vlasova, Sun Hyung Kim, Alan C. Evans, Stephen R. Dager, Annette M. Estes, Robert C. McKinstry, Kelly N. Botteron, Guido Gerig, Robert T. Schultz, Heather C. Hazlett, Joseph Piven, Catherine A. Burrows, Rebecca L. Grzadzinski, Jessica B. Girault, Mark D. Shen, and Martin A. Styner
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generative adversarial networks ,MRI ,longitudinal prediction ,machine learning ,infant ,postnatal brain development ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
The infant brain undergoes a remarkable period of neural development that is crucial for the development of cognitive and behavioral capacities (Hasegawa et al., 2018). Longitudinal magnetic resonance imaging (MRI) is able to characterize the developmental trajectories and is critical in neuroimaging studies of early brain development. However, missing data at different time points is an unavoidable occurrence in longitudinal studies owing to participant attrition and scan failure. Compared to dropping incomplete data, data imputation is considered a better solution to address such missing data in order to preserve all available samples. In this paper, we adapt generative adversarial networks (GAN) to a new application: longitudinal image prediction of structural MRI in the first year of life. In contrast to existing medical image-to-image translation applications of GANs, where inputs and outputs share a very close anatomical structure, our task is more challenging as brain size, shape and tissue contrast vary significantly between the input data and the predicted data. Several improvements over existing GAN approaches are proposed to address these challenges in our task. To enhance the realism, crispness, and accuracy of the predicted images, we incorporate both a traditional voxel-wise reconstruction loss as well as a perceptual loss term into the adversarial learning scheme. As the differing contrast changes in T1w and T2w MR images in the first year of life, we incorporate multi-contrast images leading to our proposed 3D multi-contrast perceptual adversarial network (MPGAN). Extensive evaluations are performed to assess the qualityand fidelity of the predicted images, including qualitative and quantitative assessments of the image appearance, as well as quantitative assessment on two segmentation tasks. Our experimental results show that our MPGAN is an effective solution for longitudinal MR image data imputation in the infant brain. We further apply our predicted/imputed images to two practical tasks, a regression task and a classification task, in order to highlight the enhanced task-related performance following image imputation. The results show that the model performance in both tasks is improved by including the additional imputed data, demonstrating the usability of the predicted images generated from our approach.
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- 2021
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18. Hypoxia-Enhanced N2O Production Under Ocean Acidification in the Bohai Sea
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Ting Gu, Dai Jia, Xing Ma, Liying Peng, Guicheng Zhang, Yuqiu Wei, Tingting Lou, and Jun Sun
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ocean acidification ,hypoxia ,N2O emission ,Bohai Sea ,oxygen minimum zone ,Science ,General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
Nitrous oxide (N2O) is a powerful greenhouse gas that degrades ozone. Hypoxia and ocean acidification are becoming more intense as a result of climate change. The former stimulates N2O emissions, whereas the effects of the latter on N2O production vary by the ocean. Hypoxia and ocean acidification may play a critical role in the evolution of future oceanic N2O production. However, the interactive effects of hypoxia and ocean acidification on N2O production remain unclear. We conducted a research cruise in the Bohai Sea of China to assess the occurrence of ocean acidification in the seasonal oxygen minimum zone of the sea and further conducted laboratory incubation experiments to determine the effects of ocean acidification and hypoxia on N2O production. When pH decreased by 0.25, N2O production decreased by 50.77 and 72.38%, respectively. In contrast, hypoxia had a positive impact; when dissolved oxygen (DO) decreased to 3.7 and 2.4 mg L−1, N2O production increased by 49.72 and 278.68%, respectively. The incubation experiments demonstrated that the coupling of ocean acidification and hypoxia significantly increased N2O production, but, individually, there was an antagonistic relationship between the two. Structural equation modeling showed that the total effects of hypoxia treatment on N2O production changes weakened the effects of ocean acidification, with overall positive effects. Generally speaking, our results suggest that N2O production from the coastal waters of the Bohai Sea may increase under future climate change scenarios due to increasingly serious ocean acidification and hypoxia working in combination.
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- 2021
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19. Proteomics Insights into the Gene Network of cis9, trans11-Conjugated Linoleic Acid Biosynthesis in Bovine Mammary Gland Epithelial Cells
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Liying Peng, Ge Bai, Chunzheng Wang, Jianan Dong, Yongjun Liu, Zhe Sun, Yuguo Zhen, Guixin Qin, Xuefeng Zhang, Natnael Demelash, and Tao Wang
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biosynthesis ,bovine mammary gland ,cis9, trans11-conjugated linoleic acid ,energy metabolism pathways ,MAC-T cells ,stearoyl-CoA desaturase 1 ,Veterinary medicine ,SF600-1100 ,Zoology ,QL1-991 - Abstract
The objective of the study was to elucidate the stearoyl-coenzyme A desaturase (SCD1)-dependent gene network of c9, t11-CLA biosynthesis in MAC-T cells from an energy metabolism perspective. The cells were divided into the CAY group (firstly incubated with CAY10566, a chemical inhibitor of SCD1, then incubated with trans-11-octadecenoic acid, (TVA)), the TVA group (only TVA), and the control group (without CAY, TVA). The c9, t11-CLA, and TVA contents were determined by gas chromatography. The mRNA levels of SCD1 and candidate genes were analyzed via real-time PCR. Tandem mass tag (TMT)-based quantitative proteomics, bioinformatic analysis, parallel reaction monitoring (PRM), and small RNA interference were used to explore genes involved in the SCD1-dependent c9, t11-CLA biosynthesis. The results showed that the SCD1 deficiency led by CAY10566 blocked the biosynthesis of c9, t11-CLA. In total, 60 SCD1-related proteins mainly involved in energy metabolism pathways were primarily screened by TMT-based quantitative proteomics analysis. Moreover, 17 proteins were validated using PRM analysis. Then, 11 genes were verified to have negative relationships with SCD1 after the small RNA interference analysis. Based on the above results, we concluded that genes involved in energy metabolism pathways have an impact on the SCD1-dependent molecular mechanism of c9, t11-CLA biosynthesis.
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- 2022
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20. Clinical efficacy and safety of sirolimus in systemic lupus erythematosus: a real-world study and meta-analysis
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Liying Peng, Chanyuan Wu, Ruping Hong, Yiduo Sun, Junyan Qian, Jiuliang Zhao, Qian Wang, Xinping Tian, Yanhong Wang, Mengtao Li, and Xiaofeng Zeng
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Diseases of the musculoskeletal system ,RC925-935 - Abstract
Objective: To provide real-world data and summarize current clinical evidence on the efficacy and safety of sirolimus in active systemic lupus erythematosus (SLE) patients. Methods: This was a prospective real-world clinical study. Included SLE patients should have Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) ⩾ 2. They were treated with sirolimus and followed up regularly. The SLEDAI-2K, Physician Global Assessment (PGA), serological activity indices, and remission of organ manifestations were evaluated. We also performed a meta-analysis to integrate current evidence of sirolimus in SLE. Results: A total of 49 patients were included in the final analysis. After treatment, the SLEDAI-2K (6.2 ± 3.1 versus 4.0 ± 3.4, p = 0.001) decreased significantly, and the prednisone dosage was tapered successfully (9.9 ± 8.8 mg/day versus 5.9 ± 4.0 mg/day, p = 0.002). Serological activity indices also improved [complement 3 (C3): 0.690 ± 0.209 g/l versus 0.884 ± 0.219 g/l, p
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- 2020
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21. Advancements in Hydrogel-Based Drug Sustained Release Systems for Bone Tissue Engineering
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Yunfan Zhang, Tingting Yu, Liying Peng, Qiannan Sun, Yan Wei, and Bing Han
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hydrogel ,sustained drug release ,bone tissue engineering ,growth factors ,mesenchymal stem cells ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Bone defects caused by injury, disease, or congenital deformity remain a major health concern, and efficiently regenerating bone is a prominent clinical demand worldwide. However, bone regeneration is an intricate process that requires concerted participation of both cells and bioactive factors. Mimicking physiological bone healing procedures, the sustained release of bioactive molecules plays a vital role in creating an optimal osteogenic microenvironment and achieving promising bone repair outcomes. The utilization of biomaterial scaffolds can positively affect the osteogenesis process by integrating cells with bioactive factors in a proper way. A high water content, tunable physio-mechanical properties, and diverse synthetic strategies make hydrogels ideal cell carriers and controlled drug release reservoirs. Herein, we reviewed the current advancements in hydrogel-based drug sustained release systems that have delivered osteogenesis-inducing peptides, nucleic acids, and other bioactive molecules in bone tissue engineering (BTE).
- Published
- 2020
- Full Text
- View/download PDF
22. Recent Progress in Antimicrobial Strategies for Resin-Based Restoratives
- Author
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Qiannan Sun, Lingyun Zhang, Rushui Bai, Zimeng Zhuang, Yunfan Zhang, Tingting Yu, Liying Peng, Tianyi Xin, Si Chen, and Bing Han
- Subjects
antimicrobial ,dental materials ,dental restorations ,polymeric composite ,Organic chemistry ,QD241-441 - Abstract
Repairing tooth defects with dental resin composites is currently the most commonly used method due to their tooth-colored esthetics and photocuring properties. However, the higher than desirable failure rate and moderate service life are the biggest challenges the composites currently face. Secondary caries is one of the most common reasons leading to repair failure. Therefore, many attempts have been carried out on the development of a new generation of antimicrobial and therapeutic dental polymer composite materials to inhibit dental caries and prolong the lifespan of restorations. These new antimicrobial materials can inhibit the formation of biofilms, reduce acid production from bacteria and the occurrence of secondary caries. These results are encouraging and open the doors to future clinical studies on the therapeutic value of antimicrobial dental resin-based restoratives. However, antimicrobial resins still face challenges such as biocompatibility, drug resistance and uncontrolled release of antimicrobial agents. In the future, we should focus on the development of more efficient, durable and smart antimicrobial dental resins. This article focuses on the most recent 5 years of research, reviews the current antimicrobial strategies of composite resins, and introduces representative antimicrobial agents and their antimicrobial mechanisms.
- Published
- 2021
- Full Text
- View/download PDF
23. Metallic Antibacterial Surface Treatments of Dental and Orthopedic Materials
- Author
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Rushui Bai, Liying Peng, Qiannan Sun, Yunfan Zhang, Lingyun Zhang, Yan Wei, and Bing Han
- Subjects
metallic agents ,surface treatment ,antibacterial ,dental materials ,orthopedic materials ,surface modification ,Technology ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Microscopy ,QH201-278.5 ,Descriptive and experimental mechanics ,QC120-168.85 - Abstract
The oral cavity harbors complex microbial communities, which leads to biomaterial-associated infections (BAI) during dental and orthopedic treatments. Conventional antibiotic treatments have met great challenges recently due to the increasing emergency of drug-resistant bacteria. To tackle this clinical issue, antibacterial surface treatments, containing surface modification and coatings, of dental and orthopedic materials have become an area of intensive interest now. Among various antibacterial agents used in surface treatments, metallic agents possess unique properties, mainly including broad-spectrum antibacterial properties, low potential to develop bacterial resistance, relative biocompatibility, and chemical stability. Therefore, this review mainly focuses on underlying antibacterial applications and the mechanisms of metallic agents in dentistry and orthopedics. An overview of the present review indicates that much work remains to be done to deepen the understanding of antibacterial mechanisms and potential side-effects of metallic agents.
- Published
- 2020
- Full Text
- View/download PDF
24. DeepRecS: From RECIST Diameters to Precise Liver Tumor Segmentation.
- Author
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Yue Zhang, Chengtao Peng, Liying Peng, Yingying Xu, Lanfen Lin, Ruofeng Tong 0001, Zhiyi Peng, Xiongwei Mao, Hongjie Hu, Yen-Wei Chen 0001, and Jingsong Li
- Published
- 2022
- Full Text
- View/download PDF
25. Multi-phase Liver Tumor Segmentation with Spatial Aggregation and Uncertain Region Inpainting.
- Author
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Yue Zhang, Chengtao Peng, Liying Peng, Huimin Huang, Ruofeng Tong 0001, Lanfen Lin, Jingsong Li, Yen-Wei Chen 0001, Qingqing Chen 0001, Hongjie Hu, and Zhiyi Peng
- Published
- 2021
- Full Text
- View/download PDF
26. Multi-modal Perceptual Adversarial Learning for Longitudinal Prediction of Infant MR Images.
- Author
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Liying Peng, Lanfen Lin, Yusen Lin, Yue Zhang, Roza M. Vlasova, Juan Prieto 0001, Yen-Wei Chen 0001, Guido Gerig, and Martin Styner
- Published
- 2020
- Full Text
- View/download PDF
27. Storage Reliability Evaluation based on Competing Risks of Degradation Failure and Random Failure for Missiles.
- Author
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Renqing Li, Jin Li, Jiale Lu, Liying Peng, Yan Song, Yi Wang, and Xinjie Chen
- Published
- 2020
- Full Text
- View/download PDF
28. Semi-Supervised Learning for Semantic Segmentation of Emphysema With Partial Annotations.
- Author
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Liying Peng, Lanfen Lin, Hongjie Hu, Yue Zhang, Huali Li, Yutaro Iwamoto, Xian-Hua Han, and Yen-Wei Chen 0001
- Published
- 2020
- Full Text
- View/download PDF
29. Classification of Pulmonary Emphysema in CT Images Based on Multi-Scale Deep Convolutional Neural Networks.
- Author
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Liying Peng, Lanfen Lin, Hongjie Hu, Huali Li, Xiaoli Ling, Dan Wang, Xianhua Han, Yutaro Iwamoto, and Yen-Wei Chen 0001
- Published
- 2018
- Full Text
- View/download PDF
30. Multi-scale Residual Network with Two Channels of Raw CT Image and Its Differential Excitation Component for Emphysema Classification.
- Author
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Liying Peng, Lanfen Lin, Hongjie Hu, Huali Li, Qingqing Chen 0001, Dan Wang, Xian-Hua Han, Yutaro Iwamoto, and Yen-Wei Chen 0001
- Published
- 2018
- Full Text
- View/download PDF
31. Survival Nomogram for Patients With Locally Advanced Breast Cancer Undergoing Immediate Breast Reconstruction: A SEER Population-Based Study
- Author
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Jiahao Pan, Liying Peng, Cong Xia, Anqi Wang, Xiuwen Tong, Xipei Chen, Jian Zhang, and Xinyun Xu
- Subjects
Cancer Research ,Oncology - Published
- 2023
32. Classification and Quantification of Emphysema Using a Multi-Scale Residual Network.
- Author
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Liying Peng, Yen-Wei Chen 0001, Lanfen Lin, Hongjie Hu, Huali Li, Qingqing Chen 0001, Xiaoli Ling, Dan Wang, Xianhua Han, and Yutaro Iwamoto
- Published
- 2019
- Full Text
- View/download PDF
33. Artificial Intelligence Iterative Reconstruction in Computed Tomography Angiography: An Evaluation on Pulmonary Arteries and Aorta With Routine Dose Settings.
- Author
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Huan Gong, Liying Peng, Xiangdong Du, Jiajia An, Rui Peng, Rui Guo, Xu Ma, Sining Xiong, Qin Ma, Guozhi Zhang, and Jing Ma
- Published
- 2024
- Full Text
- View/download PDF
34. Joint weber-based rotation invariant uniform local ternary pattern for classification of pulmonary emphysema in CT images.
- Author
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Liying Peng, Lanfen Lin, Hongjie Hu, Xiaoli Ling, Dan Wang, Xian-Hua Han, and Yen-Wei Chen 0001
- Published
- 2017
- Full Text
- View/download PDF
35. Single Image Super-Resolution via Convolutional Neural Network and Total Variation Regularization.
- Author
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Yanyun Qu, Cuiting Shi, Junran Liu, Liying Peng, and Xiao-Feng Du
- Published
- 2016
- Full Text
- View/download PDF
36. Screening ester-producing yeasts to fortify the brewing of rice-flavor Baijiu for enhanced aromas.
- Author
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Chunyun Qu, Liying Peng, Yongtao Fei, Jinglong Liang, Weidong Bai, and Gongliang Liu
- Published
- 2023
- Full Text
- View/download PDF
37. Hyperrealistic Rendering of Type II Endoleak
- Author
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Baolei Guo and Liying Peng
- Subjects
Radiology, Nuclear Medicine and imaging - Published
- 2023
38. DeepRecS: From RECIST Diameters to Precise Liver Tumor Segmentation
- Author
-
Xiongwei Mao, Yen-Wei Chen, Honjie Hu, Yue Zhang, Liying Peng, Lanfen Lin, Zhiyi Peng, Ruofeng Tong, Chengtao Peng, Jingsong Li, and Yingying Xu
- Subjects
Conditional random field ,Carcinoma, Hepatocellular ,Liver tumor ,Computer science ,business.industry ,Deep learning ,Liver Neoplasms ,Abdomen computed tomography ,Pattern recognition ,Image segmentation ,medicine.disease ,Computer Science Applications ,Health Information Management ,Image Processing, Computer-Assisted ,medicine ,Humans ,Liver tumor segmentation ,Segmentation ,Artificial intelligence ,Electrical and Electronic Engineering ,Tomography, X-Ray Computed ,Solid tumor ,business ,Response Evaluation Criteria in Solid Tumors ,Biotechnology - Abstract
Liver tumor segmentation (LiTS) is of primary importance in diagnosis and treatment of hepatocellular carcinoma. Known automated LiTS methods could not yield satisfactory results for clinical use since they were hard to model flexible tumor shapes and locations. In clinical practice, radiologists usually estimate tumor shape and size by a Response Evaluation Criteria in Solid Tumor (RECIST) mark. Inspired by this, in this paper, we explore a deep learning (DL) based interactive LiTS method, which incorporates guidance from user-provided RECIST marks. Our method takes a three-step framework to predict liver tumor boundaries. Under this architecture, we develop a RECIST mark propagation network (RMP-Net) to estimate RECIST-like marks in off-RECIST slices. We also devise a context-guided boundary-sensitive network (CGBS-Net) to distill tumors' contextual and boundary information from corresponding RECIST(-like) marks, and then predict tumor maps. To further refine the segmentation results, we process the tumor maps using a 3D conditional random field (CRF) algorithm and a morphology hole-filling operation. Verified on two clinical contrast-enhanced abdomen computed tomography (CT) image datasets, our proposed approach can produce promising segmentation results, and outperforms the state-of-the-art interactive segmentation methods.
- Published
- 2022
39. Poly(ionic liquid)-Based Efficient and Robust Antiseptic Spray
- Author
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Chuao Ma, Liying Peng, Rushui Bai, Yan Wei, Xi Liu, Hongliang Liu, and Li Chang
- Subjects
Aerosols ,Staphylococcus aureus ,Materials science ,Molecular Structure ,Polymers ,medicine.drug_class ,Stem Cells ,Cell Membrane ,Ionic Liquids ,Nanotechnology ,Microbial Sensitivity Tests ,Adhesion strength ,chemistry.chemical_compound ,Human health ,chemistry ,Antiseptic ,Ionic liquid ,Anti-Infective Agents, Local ,Escherichia coli ,medicine ,Ecological security ,General Materials Science ,Dental Pulp - Abstract
Exploring efficient and robust antibacterial materials is crucially important for human health and ecological security. Compared with intrinsically antibacterial materials, materials modified with antibacterial agents either by chemical or physical modification can simultaneously maintain basic functions and antibacterial properties. In particular, physical modification with antiseptic sprays is quite suitable for large-size objects in our daily life but restricted by high volatility of the antibacterial agents or poor adhesion strength between the antibacterial agents and the targeted objects. In this paper, we report a poly(ionic liquid) (PIL-Cn)-based efficient and robust antiseptic spray that exhibits long-term antibacterial properties against both Gram-positive and Gram-negative bacteria on diverse substrates, including glass, PE, and cotton. It is believed that this work will provide an alternative for current antiseptic sprays for usage in our daily life and hospitals.
- Published
- 2021
40. Research progress on ANXA5 in recurrent pregnancy loss
- Author
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Liying Peng, Wanli Yang, Xujing Deng, and Shihua Bao
- Subjects
Abortion, Habitual ,Immunology ,Obstetrics and Gynecology ,Polymorphism, Single Nucleotide ,Reproductive Medicine ,Haplotypes ,Pregnancy ,Case-Control Studies ,Immunology and Allergy ,Humans ,Female ,Genetic Predisposition to Disease ,Annexin A5 ,Promoter Regions, Genetic - Abstract
The incidence of recurrent pregnancy loss (RPL) in fertile women ranges from 1% to 5%, of which about 50% of them are due to unknown causes. The possible pathogenesis of RPL is an urgent problem to be solved in the clinical. Mutations or polymorphisms of certain genes in the coagulation mechanism are associated with susceptibility to thrombotic diseases and are one of the main reasons for the occurrence of RPL. Among them, the ANXA5 gene was newly studied and some single nucleotide polymorphisms (SNPs) in the promoter region of ANXA5 have been reported to be associated with RPL in multiple races. In this review, we summarized the research progress on the correlation between the SNPs in ANXA5 and RPL, hoping to provide some valuable guidance for the future studies.
- Published
- 2022
41. Distribution, source identification and ecological effects of aerosol dissolved nutrients in the Bohai Bay
- Author
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Xudong Cui, Liying Peng, Yu Guo, Guicheng Zhang, Haijiao Liu, Yujian Wen, Guodong Zhang, and Jun Sun
- Subjects
Health, Toxicology and Mutagenesis ,General Medicine ,Toxicology ,Pollution - Published
- 2023
42. Sirolimus versus tacrolimus for systemic lupus erythematosus treatment: results from a real-world CSTAR cohort study
- Author
-
Nan Jiang, Mengtao Li, Hongfeng Zhang, Xinwang Duan, Xiaofeng Li, Yongfei Fang, Hongbin Li, Pingting Yang, Hui Luo, Yanhong Wang, Liying Peng, Jiuliang Zhao, Chanyuan Wu, Qian Wang, Xinping Tian, Yan Zhao, and Xiaofeng Zeng
- Subjects
Sirolimus ,Immunology ,General Medicine ,systemic ,equipment and supplies ,Tacrolimus ,Cohort Studies ,surgical procedures, operative ,cardiovascular system ,therapeutics ,Clinical Trials and Drug Discovery ,Humans ,Lupus Erythematosus, Systemic ,autoimmune diseases ,cardiovascular diseases ,skin and connective tissue diseases ,lupus erythematosus ,Immunosuppressive Agents - Abstract
ObjectiveThe effectiveness and safety of sirolimus for SLE treatment have been shown in some uncontrolled studies. However, a comparison of sirolimus with other classic immunosuppressants has not been reported. We conducted the study to compare the effectiveness and safety of sirolimus versus tacrolimus for SLE treatment.MethodsA real-world cohort study was conducted. Patients with clinically active SLE who were prescribed sirolimus or tacrolimus were enrolled. Propensity score matching was used to ensure equivalent disease conditions and background medications. SLE disease activity indices, serological parameters, steroid doses, modification of other immunosuppressants, renal effectiveness and adverse events were compared between the two groups at 3-month, 6-month, 9-month and 12-month follow-up visits.ResultsData from 52 patients in each of the sirolimus and tacrolimus groups were analysed. Indices regarding the effectiveness of sirolimus, including Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) scores, physician’s global assessment (PhGA) scores, and proportion of patients with SLEDAI-2K reduction of ≥4 and PhGA increase of ConclusionsOverall, sirolimus was as effective as tacrolimus in the treatment of SLE. Sirolimus had better effects on serological improvement and glucocorticoid tapering. Sirolimus was well tolerated in patients with SLE.
- Published
- 2022
43. Semi-Supervised Learning for Semantic Segmentation of Emphysema With Partial Annotations
- Author
-
Yue Zhang, Xian-Hua Han, Lanfen Lin, Yen-Wei Chen, Yutaro Iwamoto, Liying Peng, Huali Li, and Hongjie Hu
- Subjects
Male ,Computer science ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,Pulmonary disease ,02 engineering and technology ,Semi-supervised learning ,Semantics ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Deep Learning ,0302 clinical medicine ,Health Information Management ,Discriminative model ,0202 electrical engineering, electronic engineering, information engineering ,Humans ,Segmentation ,Electrical and Electronic Engineering ,Lung ,Emphysema ,Pixel ,business.industry ,Pattern recognition ,Image segmentation ,Computer Science Applications ,ComputingMethodologies_PATTERNRECOGNITION ,Radiographic Image Interpretation, Computer-Assisted ,Female ,020201 artificial intelligence & image processing ,Supervised Machine Learning ,Artificial intelligence ,Tomography, X-Ray Computed ,business ,Biotechnology - Abstract
Segmentation and quantification of each subtype of emphysema is helpful to monitor chronic obstructive pulmonary disease. Due to the nature of emphysema (diffuse pulmonary disease), it is very difficult for experts to allocate semantic labels to every pixel in the CT images. In practice, partially annotating is a better choice for the radiologists to reduce their workloads. In this paper, we propose a new end-to-end trainable semi-supervised framework for semantic segmentation of emphysema with partial annotations, in which a segmentation network is trained from both annotated and unannotated areas. In addition, we present a new loss function, referred to as Fisher loss, to enhance the discriminative power of the model and successfully integrate it into our proposed framework. Our experimental results show that the proposed methods have superior performance over the baseline supervised approach (trained with only annotated areas) and outperform the state-of-the-art methods for emphysema segmentation.
- Published
- 2020
44. Hydrogel-Coated Dental Device with Adhesion-Inhibiting and Colony-Suppressing Properties
- Author
-
Liying Peng, Mengting Si, Hongliang Liu, Yan Wei, Shutao Wang, Lei Jiang, Li Chang, Bing Han, and Jiuxiang Lin
- Subjects
Materials science ,Biocompatibility ,Orthodontic Brackets ,Biointerface ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Bacterial Adhesion ,Streptococcus mutans ,Chitosan ,chemistry.chemical_compound ,Anti-Infective Agents ,Coated Materials, Biocompatible ,PEG ratio ,Humans ,General Materials Science ,Bone regeneration ,technology, industry, and agriculture ,Hydrogels ,021001 nanoscience & nanotechnology ,Antimicrobial ,0104 chemical sciences ,chemistry ,Drug delivery ,Self-healing hydrogels ,0210 nano-technology ,Biomedical engineering - Abstract
Bacterial infection is the main cause of implantation failure worldwide, and the importance of antibiotics on medical devices has been undermined because of antibiotic resistance. Antimicrobial hydrogels have emerged as a promising approach to combat infections associated with medical devices and wound healing. However, hydrogel coatings that simultaneously possess both antifouling and antimicrobial attributes are scarce. Herein, we report an antimicrobial hydrogel that incorporates adhesion-inhibiting polyethylene glycol (PEG) and colony-suppressing chitosan (CS) as a dressing to combat bacterial infections. These two polymers have important environmentally benign characteristics including low toxicity, low volatility, and biocompatibility. Although hydrogels containing PEG and CS have been reported for applications in the fields of wound dressing, tissue repair, water purification, drug delivery, and scaffolds for bone regeneration, there still has been no report on the application of CS/PEG hydrogel coatings in dental applications. Herein, this biointerface shows superior activity in early-stage adhesion inhibition (98.8%, 5 h) and displays remarkably long-lasting colony-suppression activity (93.3%, 7 d). Thus, this novel nanomaterial, which has potential as a dual-functional platform with integrated antifouling and antimicrobial functions with excellent biocompatibility, might be used as a safe and effective antimicrobial coating in biomedical device applications.
- Published
- 2020
45. A Middle-Aged Man With Skin Lesions, Progressive Deterioration of Renal Function, and Pulmonary Cheerios
- Author
-
Jun Feng, Liying Peng, and Xuefeng Sun
- Subjects
Microbiology (medical) ,Male ,Pathology ,medicine.medical_specialty ,Lung ,business.industry ,Renal function ,Middle Aged ,Kidney ,Skin Diseases ,Infectious Diseases ,medicine.anatomical_structure ,medicine ,Humans ,Middle-aged adult ,business ,Skin lesion - Published
- 2021
46. Recent Progress in Antimicrobial Strategies for Resin-Based Restoratives
- Author
-
Zimeng Zhuang, Qiannan Sun, Liying Peng, Chen Si, Tingting Yu, Rushui Bai, Bing Han, Yunfan Zhang, Lingyun Zhang, and Tianyi Xin
- Subjects
Polymers and Plastics ,Dental resins ,Resin composite ,Dentistry ,Organic chemistry ,02 engineering and technology ,Drug resistance ,Review ,03 medical and health sciences ,0302 clinical medicine ,QD241-441 ,stomatognathic system ,Still face ,Medicine ,dental materials ,dental restorations ,business.industry ,030206 dentistry ,General Chemistry ,Polymer composite materials ,021001 nanoscience & nanotechnology ,Antimicrobial ,Acid production ,stomatognathic diseases ,antimicrobial ,0210 nano-technology ,business ,polymeric composite - Abstract
Repairing tooth defects with dental resin composites is currently the most commonly used method due to their tooth-colored esthetics and photocuring properties. However, the higher than desirable failure rate and moderate service life are the biggest challenges the composites currently face. Secondary caries is one of the most common reasons leading to repair failure. Therefore, many attempts have been carried out on the development of a new generation of antimicrobial and therapeutic dental polymer composite materials to inhibit dental caries and prolong the lifespan of restorations. These new antimicrobial materials can inhibit the formation of biofilms, reduce acid production from bacteria and the occurrence of secondary caries. These results are encouraging and open the doors to future clinical studies on the therapeutic value of antimicrobial dental resin-based restoratives. However, antimicrobial resins still face challenges such as biocompatibility, drug resistance and uncontrolled release of antimicrobial agents. In the future, we should focus on the development of more efficient, durable and smart antimicrobial dental resins. This article focuses on the most recent 5 years of research, reviews the current antimicrobial strategies of composite resins, and introduces representative antimicrobial agents and their antimicrobial mechanisms.
- Published
- 2021
47. Independent activation of the BoMYB2 gene leading to purple traits in Brassica oleracea
- Author
-
Hanhui Kuang, Jiongjiong Chen, Weiyi Zhang, Lei Zhang, Ting Zhu, Liying Peng, Chenghuan Yan, and Guanghui An
- Subjects
0106 biological sciences ,Transposable element ,Genotype ,Sequence analysis ,Arabidopsis ,Locus (genetics) ,Brassica ,Biology ,Genes, Plant ,01 natural sciences ,Anthocyanins ,Quantitative Trait, Heritable ,Gene Expression Regulation, Plant ,Genetic variation ,Genetics ,Selection, Genetic ,Allele ,Promoter Regions, Genetic ,Gene ,Alleles ,Phylogeny ,Plant Proteins ,Regulation of gene expression ,Base Sequence ,Pigmentation ,Genetic Variation ,General Medicine ,Plants, Genetically Modified ,biology.organism_classification ,Biosynthetic Pathways ,Phenotype ,Mutation ,DNA Transposable Elements ,Brassica oleracea ,Agronomy and Crop Science ,010606 plant biology & botany ,Biotechnology - Abstract
Transposon insertion and point mutation independently activated the BoMYB2 gene in three purple cultivars of Brassica oleracea including kale, kohlrabi, and cabbage. Several varieties of B. oleracea have both green and purple cultivars. In this study, the causal genes for the purple traits in kale, kohlrabi and cabbage were cloned using map-based cloning approach. The purple traits in all three varieties were mapped to the same locus as the BoMYB2 gene in cauliflower. Surprisingly, the insertion of Harbinger transposon of BoMYB2 in cauliflower was not found in purple kale, kohlrabi and cabbage. Sequencing of the BoMYB2 gene in purple kale and purple kohlrabi discovered a 7606 bp CACTA-like transposon in its promoter region. Transient assay and promoter activity study showed that the insertion upregulated the expression of the BoMYB2 gene. On the other hand, the activation of the BoMYB2 gene in purple cabbage was caused by point mutation and/or 1-bp insertion in its promoter region. Sequence analysis of the BoMYB2 gene in different varieties suggested that the activating events most likely occurred independently after the divergence of cabbage, cauliflower, and kale/kohlrabi. Our results not only contribute to a better understanding of anthocyanin inheritance in B. oleracea, but also provide useful information for future hybrid breeding of purple cultivars through combination of different functional alleles of the BoMYB2 gene.
- Published
- 2018
48. Multi-phase Liver Tumor Segmentation with Spatial Aggregation and Uncertain Region Inpainting
- Author
-
Lanfen Lin, Yen-Wei Chen, Yue Zhang, Jingsong Li, Hongjie Hu, Huimin Huang, Chengtao Peng, Qingqing Chen, Ruofeng Tong, Zhiyi Peng, and Liying Peng
- Subjects
Pixel ,Discriminative model ,Computer science ,Feature (computer vision) ,business.industry ,Aggregate (data warehouse) ,Concatenation ,Inpainting ,Boundary (topology) ,Segmentation ,Pattern recognition ,Artificial intelligence ,business - Abstract
Multi-phase computed tomography (CT) images provide crucial complementary information for accurate liver tumor segmentation (LiTS). State-of-the-art multi-phase LiTS methods usually fused cross-phase features through phase-weighted summation or channel-attention based concatenation. However, these methods ignored the spatial (pixel-wise) relationships between different phases, hence leading to insufficient feature integration. In addition, the performance of existing methods remains subject to the uncertainty in segmentation, which is particularly acute in tumor boundary regions. In this work, we propose a novel LiTS method to adequately aggregate multi-phase information and refine uncertain region segmentation. To this end, we introduce a spatial aggregation module (SAM), which encourages per-pixel interactions between different phases, to make full use of cross-phase information. Moreover, we devise an uncertain region inpainting module (URIM) to refine uncertain pixels using neighboring discriminative features. Experiments on an in-house multi-phase CT dataset of focal liver lesions (MPCT-FLLs) demonstrate that our method achieves promising liver tumor segmentation and outperforms state-of-the-arts.
- Published
- 2021
49. Fine mapping of a candidate gene for cool-temperature-induced albinism in ornamental kale
- Author
-
Lei Zhang, Zhengming Qiu, Liying Peng, and Chenghuan Yan
- Subjects
0106 biological sciences ,0301 basic medicine ,Candidate gene ,Chloroplasts ,Photoperiod ,Mutant ,Locus (genetics) ,Brassica ,Plant Science ,Biology ,Genes, Plant ,01 natural sciences ,Genetic analysis ,Chromosomes, Plant ,03 medical and health sciences ,Genetic linkage ,Albino trait ,lcsh:Botany ,medicine ,Cytochrome P450 gene ,RNA-Seq ,Gene ,Genetics ,Chlorosis ,BSR-seq ,Pigmentation ,Chromosome Mapping ,Ornamental kale ,medicine.disease ,lcsh:QK1-989 ,Cold Temperature ,Phenotype ,030104 developmental biology ,Albinism ,Semi-dominant inheritance ,Research Article ,010606 plant biology & botany - Abstract
Background The symptoms of cool-temperature-induced chlorosis (CTIC) are widely existed in higher plants. Although many studies have shown that the genetic mechanism of CTIC is generally controlled by recessive genes in model plants, the dominant inheritance of albinism has not been reported thus far. Here, two CTIC mutants, Red Kamome and White Kamome, were utilized to analyse the inheritance of the albino trait in ornamental kale. The objective of this investigation is to fine-map the target locus and identify the most likely candidate genes for albinism. Results Genetic analysis revealed that the albinism in the inner leaves of ornamental kale followed semi-dominant inheritance and was controlled by a single locus in two segregating populations. BSR-seq in combination with linkage analysis was employed to fine-map the causal gene, named AK (Albino Kale), to an approximate 60 kb interval on chromosome C03. Transcriptome data from two extreme pools indicated that the differentially expressed gene of Bol015404, which encodes a cytochrome P450 protein, was the candidate gene. The Bol015404 gene was demonstrated to be upregulated in the albino leaves of ornamental kale by qPCR. Additionally, the critical temperature for the albinism was determined between 10 °C and 16 °C by gradient test. Conclusions Using two independent segregating populations, the albino mutants were shown to be controlled by one semi-dominant gene, AK, in ornamental kale. The Bol015404 gene was co-segregated with albinism phenotypes, suggesting this unknown function P450 gene as the most likely candidate gene. The albino trait appeared caused by the low temperatures rather than photoperiod. Our results lay a solid foundation on the genetic control of albinism in ornamental kale.
- Published
- 2020
50. Metallic Antibacterial Surface Treatments of Dental and Orthopedic Materials
- Author
-
Lingyun Zhang, Bing Han, Yan Wei, Rushui Bai, Liying Peng, Yunfan Zhang, and Qiannan Sun
- Subjects
orthopedic materials ,Nanotechnology ,Review ,02 engineering and technology ,010402 general chemistry ,Oral cavity ,01 natural sciences ,lcsh:Technology ,metallic agents ,Medicine ,dental materials ,General Materials Science ,lcsh:Microscopy ,lcsh:QC120-168.85 ,lcsh:QH201-278.5 ,business.industry ,lcsh:T ,coating ,surface treatment ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,antibacterial ,lcsh:TA1-2040 ,Surface modification ,lcsh:Descriptive and experimental mechanics ,lcsh:Electrical engineering. Electronics. Nuclear engineering ,0210 nano-technology ,business ,lcsh:Engineering (General). Civil engineering (General) ,surface modification ,lcsh:TK1-9971 - Abstract
The oral cavity harbors complex microbial communities, which leads to biomaterial-associated infections (BAI) during dental and orthopedic treatments. Conventional antibiotic treatments have met great challenges recently due to the increasing emergency of drug-resistant bacteria. To tackle this clinical issue, antibacterial surface treatments, containing surface modification and coatings, of dental and orthopedic materials have become an area of intensive interest now. Among various antibacterial agents used in surface treatments, metallic agents possess unique properties, mainly including broad-spectrum antibacterial properties, low potential to develop bacterial resistance, relative biocompatibility, and chemical stability. Therefore, this review mainly focuses on underlying antibacterial applications and the mechanisms of metallic agents in dentistry and orthopedics. An overview of the present review indicates that much work remains to be done to deepen the understanding of antibacterial mechanisms and potential side-effects of metallic agents.
- Published
- 2020
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