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1,018 results on '"Liu, Xiangmei"'

21. Discussion on Expression of Laboratory Accreditation Scope in the Field of Toxicology Testing

Author

LIU Xiangmei, MA Zhongchun, FU Hongkun, GAO Feng, and TAO Yufeng

Subjects
field of toxicology testing, authorized institution, expression scope of accreditation, animal experiments, Medicine
Abstract

With the series of regulations issued by the State Administration for Market Regulation entitled "Release, Regulation, and Service" and the rapid development of the biomedical health industry, the demand for toxicology testing is increasing, and the number of testing institutions is also growing. Statements of accreditation capacity scope of toxicology laboratories must also be more specialized and international. In this paper, the project classification, detection objects, items/parameters, statements of accreditation and scope of the Chinese regulatory toxicology testing field were described. The accreditation capacity scope of 4 mainstream international accreditation institutions in the field of toxicology testing, in New Zealand, the United States, Japan, and the United Kingdom, was organized and analyzed. Results showed that China, New Zealand and other countries mentioned above used the same basic expression regarding the scope of accreditation capacity in the field of toxicology testing; these expressions covered detection objects, detection methods/technologies, detection standards and field codes, but their classification principles for codes varied slightly. In order to standardize and uniformly express the scope of accreditation capacity in this field and improve the professional level of laboratories, this study puts forth suggestions on detection objects, items/parameters, field codes, names(method)and numbers(including year numbers) of detection standards, and the scope of limitations.

Published
2022
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27. Research Progress on Alternative Methods of Skin Sensitization Test

Author

HUANG Jingyi, LI Peining, LIU Xiangmei, LIU Zhonghua, and HUANG Yufeng

Subjects
skin sensitization experiment, allergic contact dermatitis, alternative method, Medicine
Abstract

Allergic contact dermatitis is a type Ⅳ hypersensitivity reaction caused by repeated skin exposure to a substance and is a common public health problem. Traditional skin sensitization tests are based on animal experiments such as guinea pig maximum test and closed patch. In recent years, with the increasing attention of animal ethics and the development of science and technology, alternative methods of skin sensitization test have emerged. According to different principles, these alternative methods are divided into in vivo alternative methods, several in vitro alternative methods based on harmful outcome pathways, and genomic allergen rapid test, etc. In this paper, we reviewed the progress of these alternative methods of skin sensitization test, and several integrated testing and evaluation methods based on adverse outcome pathways.

Published
2022
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44. Photosono-Responsive BiOCl@Bi2S3 Heterostructure for Rapid Bacteria Killing.

Author

Yang, Zhenxing, Chen, Cuihong, Li, Wenxiang, Wang, Chaofeng, Liu, Xiangmei, Ran, Qian, Mao, Congyang, Zheng, Yufeng, Zhang, Yu, Shen, Jie, and Wu, Shuilin

Abstract

The emergence of drug-resistant bacteria poses a serious threat to human health and safety, thus requiring the exploration of effective antibacterial strategies. Herein, BiOCl nanosheets were synthesized using a polyol solvothermal method, and then Bi2S3 nanorods were in situ grown on the surface of BiOCl by doping S element with thioacetamide, forming BiOCl@Bi2S3 composites. The experimental results show that in comparison to BiOCl nanosheets, the BiOCl@Bi2S3 composite enhances the photodynamic, sonodynamic, and thermal effects under the combined action of ultrasound (US) and 808 nm near-infrared (NIR) light to generate more radical oxygen species (ROS) and induces local hyperthermia. Therefore, under the conditions of photoacoustic combination for 20 min, the composite material has excellent rapid antibacterial effect of 99.7% against Staphylococcus aureus and 100.0% against Escherichia coli. Additionally, the BiOCl@Bi2S3 composite has a good biocompatibility with NIH-3T3 cells. This study will provide insights into the design of efficient and safe antibacterial materials. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Transfer Interface‐Controlled Printing of 2D MOF for Charge‐Transfer Dynamics Engineering through Ultrasound‐Promoted Hetero‐Interfacial Polarization.

Author

Li, Jun, Wu, Shuilin, Zheng, Yufeng, Wang, Chaofeng, Cui, Zhenduo, Li, Zhaoyang, Zhu, Shengli, Jiang, Hui, Chu, Paul K, and Liu, Xiangmei

Subjects
CHARGE transfer, TRANSFER printing, REACTIVE oxygen species, NANOFILMS, HETEROSTRUCTURES, OSSEOINTEGRATION, KELVIN probe force microscopy
Abstract

Understanding ultrasound‐induced charge transfer of 2D metal‐organic framework (2DMOF) nanofilms and their broad applications remain elusive. Herein, the "transfer interface‐controlled printing" 2DMOF high‐quality nanofilm is reported and in situ ultrasound‐irradiated Kelvin probe force microscopy is developed to trace the charge transfer dynamics at the nanoscale. Uniformly distributed, vertical/planar MoS2 nanosheets are grown on a porphyrin‐based 2DMOF and the local potential difference and piezoelectric polarization in these parallel and vertical 2DMOF‐MoS2 heterostructures generate a local internal polarization field to induce efficient interfacial charge transfer. This sonocatalytic platform improves electron–hole pair separation and sonocatalytic activity to boost reactive oxygen species (ROS) generation, providing a superior therapeutic effect against dental peri‐implant infection because effective ROS generation and stable Zn2+ release results in rapid peri‐implant anti‐infection and enhanced osseointegration at the bone–implant interface. This study offers a guideline for the optimization of charge transfer pathway of 2DMOF heterostructures with uniformity, thickness controllability, large‐scale and universal deposition, high catalytic efficiency, and abundant active site exposure for diverse advanced applications. [ABSTRACT FROM AUTHOR]

Published
2024
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