17 results on '"Liu, Jason Z."'
Search Results
2. Uncommon Cause of Internal Mammary Artery Pseudoaneurysm
- Author
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Prasad, Rohan M., primary, Liu, Jason Z., additional, Garces, Christopher, additional, Duwadi, Ayushma, additional, Choi, James, additional, Anwar, Farah, additional, and Olomu, Adesuwa, additional
- Published
- 2022
- Full Text
- View/download PDF
3. Dermatologic Manifestation of Acro-Ischemia Associated With COVID-19
- Author
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Gumbita, Robert, primary, Liu, Jason Z., additional, Prasad, Rohan Madhu, additional, Radwan, Yasser, additional, and Nabeel, Muhammad, additional
- Published
- 2022
- Full Text
- View/download PDF
4. Effect of Five Genetic Variants Associated with Lung Function on the Risk of Chronic Obstructive Lung Disease, and Their Joint Effects on Lung Function
- Author
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Artigas, María Soler, Wain, Louise V., Repapi, Emmanouela, Obeidat, Maʼen, Sayers, Ian, Burton, Paul R., Johnson, Toby, Zhao, Jing Hua, Albrecht, Eva, Dominiczak, Anna F., Kerr, Shona M., Smith, Blair H., Cadby, Gemma, Hui, Jennie, Palmer, Lyle J., Hingorani, Aroon D., Wannamethee, Goya S., Whincup, Peter H., Ebrahim, Shah, Smith, George Davey, Barroso, Inês, Loos, Ruth J. F., Wareham, Nicholas J., Cooper, Cyrus, Dennison, Elaine, Shaheen, Seif O., Liu, Jason Z., Marchini, Jonathan, Dahgam, Santosh, Naluai, Åsa Torinsson, Olin, Anna-Carin, Karrasch, Stefan, Heinrich, Joachim, Schulz, Holger, McKeever, Tricia M., Pavord, Ian D., Heliövaara, Markku, Ripatti, Samuli, Surakka, Ida, Blakey, John D., Kähönen, Mika, Britton, John R., Nyberg, Fredrik, Holloway, John W., Lawlor, Debbie A., Morris, Richard W., James, Alan L., Jackson, Cathy M., Hall, Ian P., and Tobin, Martin D.
- Published
- 2011
- Full Text
- View/download PDF
5. Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function
- Author
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Sood, Akshay, Liu, Jason Z., Smolonska, Joanna, Burkart, Kristin M., Elliott, Paul, Manning, Alisa K., Imboden, Medea, Homuth, Georg, Loth, Daan W., Eijgelsheim, Mark, Zhao, Jing Hua, Aschard, Hugues, Janson, Christer, Smith, Albert V., Lohman, Kurt, Artigas, María Soler, Gu, Xiangjun, Tang, Wenbo, Zhai, Guangju, Hysi, Pirro G., Curjuric, Ivan, Wilk, Jemma B., Loos, Ruth J. F., Koch, Beate, McArdle, Wendy L., Harris, Tamara B., Henry, Amanda, Loehr, Laura R., Gharib, Sina A., Manichaikul, Ani, Hancock, Dana B., and Ramasamy, Adaikalavan
- Subjects
respiratory system ,respiratory tract diseases - Abstract
Genome-wide association studies have identified numerous genetic loci for spirometic measures of pulmonary function, forced expiratory volume in one second (FEV1), and its ratio to forced vital capacity (FEV1/FVC). Given that cigarette smoking adversely affects pulmonary function, we conducted genome-wide joint meta-analyses (JMA) of single nucleotide polymorphism (SNP) and SNP-by-smoking (ever-smoking or pack-years) associations on FEV1 and FEV1/FVC across 19 studies (total N = 50,047). We identified three novel loci not previously associated with pulmonary function. SNPs in or near DNER (smallest P JMA = 5.00×10−11), HLA-DQB1 and HLA-DQA2 (smallest P JMA = 4.35×10−9), and KCNJ2 and SOX9 (smallest P JMA = 1.28×10−8) were associated with FEV1/FVC or FEV1 in meta-analysis models including SNP main effects, smoking main effects, and SNP-by-smoking (ever-smoking or pack-years) interaction. The HLA region has been widely implicated for autoimmune and lung phenotypes, unlike the other novel loci, which have not been widely implicated. We evaluated DNER, KCNJ2, and SOX9 and found them to be expressed in human lung tissue. DNER and SOX9 further showed evidence of differential expression in human airway epithelium in smokers compared to non-smokers. Our findings demonstrated that joint testing of SNP and SNP-by-environment interaction identified novel loci associated with complex traits that are missed when considering only the genetic main effects.
- Published
- 2012
- Full Text
- View/download PDF
6. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function
- Author
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Soler Artigas, María, Loth, Daan W, Wain, Louise V, Gharib, Sina A, Obeidat, Ma'en, Tang, Wenbo, Zhai, Guangju, Zhao, Jing Hua, Smith, Albert Vernon, Huffman, Jennifer E, Albrecht, Eva, Jackson, Catherine M, Evans, David M, Cadby, Gemma, Fornage, Myriam, Manichaikul, Ani, Lopez, Lorna M, Johnson, Toby, Aldrich, Melinda C, Aspelund, Thor, Barroso, Inês, Campbell, Harry, Cassano, Patricia A, Couper, David J, Eiriksdottir, Gudny, Franceschini, Nora, Garcia, Melissa, Gieger, Christian, Gislason, Gauti Kjartan, Grkovic, Ivica, Hammond, Christopher J, Hancock, Dana B, Harris, Tamara B, Ramasamy, Adaikalavan, Heckbert, Susan R, Heliövaara, Markku, Homuth, Georg, Hysi, Pirro G, James, Alan L, Jankovic, Stipan, Joubert, Bonnie R, Karrasch, Stefan, Klopp, Norman, Koch, Beate, Kritchevsky, Stephen B, Launer, Lenore J, Liu, Yongmei, Loehr, Laura R, Lohman, Kurt, Loos, Ruth JF, Lumley, Thomas, Al Balushi, Khalid A, Ang, Wei Q, Barr, R Graham, Beilby, John, Blakey, John D, Boban, Mladen, Boraska, Vesna, Brisman, Jonas, Britton, John R, Brusselle, Guy G, Cooper, Cyrus, Curjuric, Ivan, Dahgam, Santosh, Deary, Ian J, Ebrahim, Shah, Eijgelsheim, Mark, Francks, Clyde, Gaysina, Darya, Granell, Raquel, Gu, Xiangjun, Hankinson, John L, Hardy, Rebecca, Harris, Sarah E, Henderson, John, Henry, Amanda, Hingorani, Aroon D, Hofman, Albert, Holt, Patrick G, Hui, Jennie, Hunter, Michael L, Imboden, Medea, Jameson, Karen A, Kerr, Shona M, Kolcic, Ivana, Kronenberg, Florian, Liu, Jason Z, Marchini, Jonathan, McKeever, Tricia, Morris, Andrew D, Olin, Anna-Carin, Porteous, David J, Postma, Dirkje S, Rich, Stephen S, Ring, Susan M, Rivadeneira, Fernando, Rochat, Thierry, Sayer, Avan Aihie, Sayers, Ian, Sly, Peter D, Smith, George Davey, Sood, Akshay, Starr, John M, Uitterlinden, André G, Vonk, Judith M, Wannamethee, S Goya, Whincup, Peter H, Wijmenga, Cisca, Williams, O Dale, Wong, Andrew, Mangino, Massimo, Marciante, Kristin D, McArdle, Wendy L, Meibohm, Bernd, Morrison, Alanna C, North, Kari E, Omenaas, Ernst, Palmer, Lyle J, Pietiläinen, Kirsi H, Pin, Isabelle, Pola Sbreve Ek, Ozren, Pouta, Anneli, Psaty, Bruce M, Hartikainen, Anna-Liisa, Rantanen, Taina, Ripatti, Samuli, Rotter, Jerome I, Rudan, Igor, Rudnicka, Alicja R, Schulz, Holger, Shin, So-Youn, Spector, Tim D, Surakka, Ida, Vitart, Veronique, Völzke, Henry, Wareham, Nicholas J, Warrington, Nicole M, Wichmann, H-Erich, Wild, Sarah H, Wilk, Jemma B, Wjst, Matthias, Wright, Alan F, Zgaga, Lina, Zemunik, Tatijana, Pennell, Craig E, Nyberg, Fredrik, Kuh, Diana, Holloway, John W, Boezen, H Marike, Lawlor, Debbie A, Morris, Richard W, Probst-Hensch, Nicole, International Lung Cancer Consortium, GIANT consortium, Kaprio, Jaakko, Wilson, James F, Hayward, Caroline, Kähönen, Mika, Heinrich, Joachim, Musk, Arthur W, Jarvis, Deborah L, Gläser, Sven, Järvelin, Marjo-Riitta, Ch Stricker, Bruno H, Elliott, Paul, O'Connor, George T, Strachan, David P, London, Stephanie J, Hall, Ian P, Gudnason, Vilmundur, and Tobin, Martin D
- Abstract
Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 × 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.
- Published
- 2011
7. Abstract 272: Chronic Hyperlipidemia Alters the Population of Endothelial Progenitor Cells in Bone Marrow and Peripheral Circulation via Both ROS-dependent and Independent Mechanisms
- Author
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Liu, Dylan Z, primary, Cui, Yuqi, additional, Liu, Jason Z, additional, Liu, Lingjuan, additional, Li, Xin, additional, Xiao, Yuan, additional, Zhang, Jia, additional, Xie, Xiaoyun, additional, Hao, Hong, additional, He, Guanglong, additional, Parthasarathy, Sampath, additional, and Zhu, Hua, additional
- Published
- 2015
- Full Text
- View/download PDF
8. Abstract 565: Ambient Fine Particulate Matter Decreases Endothelial Progenitor Cells Through Reactive Oxygen Species-mediated Apoptosis
- Author
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Cui, Yuqi, primary, Xie, Xiaoyun, additional, Liu, Jason Z, additional, Jia, Fengpeng, additional, He, Jianfeng, additional, Hao, Hong, additional, Liu, Ying, additional, Cowan, Peter J, additional, Zhu, Hua, additional, Sun, Qinghua, additional, and Liu, Zhenguo, additional
- Published
- 2015
- Full Text
- View/download PDF
9. Ambient Fine Particulate Matter Induces Apoptosis of Endothelial Progenitor Cells Through Reactive Oxygen Species Formation
- Author
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Cui, Yuqi, primary, Xie, Xiaoyun, additional, Jia, Fengpeng, additional, He, Jianfeng, additional, Li, Zhihong, additional, Fu, Minghuan, additional, Hao, Hong, additional, Liu, Ying, additional, Liu, Jason Z., additional, Cowan, Peter J., additional, Zhu, Hua, additional, Sun, Qinghua, additional, and Liu, Zhenguo, additional
- Published
- 2015
- Full Text
- View/download PDF
10. Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function
- Author
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Hancock, Dana B, Artigas, María Soler, Gharib, Sina A, Henry, Amanda, Manichaikul, Ani, Ramasamy, Adaikalavan, Loth, Daan W, Imboden, Medea, Koch, Beate, McArdle, Wendy L, Smith, Albert V, Smolonska, Joanna, Sood, Akshay, Tang, Wenbo, Wilk, Jemma B, Zhai, Guangju, Zhao, Jing Hua, Aschard, Hugues, Burkart, Kristin M, Curjuric, Ivan, Eijgelsheim, Mark, Elliott, Paul, Gu, Xiangjun, Harris, Tamara B, Janson, Christer, Homuth, Georg, Hysi, Pirro G, Liu, Jason Z, Loehr, Laura R, Lohman, Kurt, Loos, Ruth J F, Manning, Alisa K, Marciante, Kristin D, Obeidat, Ma'en, Postma, Dirkje S, Aldrich, Melinda C, Brusselle, Guy G, Chen, Ting-Hsu, Eiriksdottir, Gudny, Franceschini, Nora, Heinrich, Joachim, Rotter, Jerome I, Wijmenga, Cisca, Williams, O Dale, Bentley, Amy R, Hofman, Albert, Laurie, Cathy C, Lumley, Thomas, Morrison, Alanna C, Joubert, Bonnie R, Rivadeneira, Fernando, Couper, David J, Kritchevsky, Stephen B, Liu, Yongmei, Wjst, Matthias, Wain, Louise V, Vonk, Judith M, Uitterlinden, André G, Rochat, Thierry, Rich, Stephen S, Psaty, Bruce M, O'Connor, George T, North, Kari E, Mirel, Daniel B, Meibohm, Bernd, Launer, Lenore J, Khaw, Kay-Tee, Hartikainen, Anna-Liisa, Hammond, Christopher J, Gläser, Sven, Marchini, Jonathan, Kraft, Peter, Wareham, Nicholas J, Völzke, Henry, Stricker, Bruno H C, Spector, Timothy D, Probst-Hensch, Nicole M, Jarvis, Deborah, Jarvelin, Marjo-Riitta, Heckbert, Susan R, Gudnason, Vilmundur, Boezen, H Marike, Barr, R Graham, Cassano, Patricia A, Strachan, David P, Fornage, Myriam, Hall, Ian P, Dupuis, Josée, Tobin, Martin D, London, Stephanie J, Hancock, Dana B, Artigas, María Soler, Gharib, Sina A, Henry, Amanda, Manichaikul, Ani, Ramasamy, Adaikalavan, Loth, Daan W, Imboden, Medea, Koch, Beate, McArdle, Wendy L, Smith, Albert V, Smolonska, Joanna, Sood, Akshay, Tang, Wenbo, Wilk, Jemma B, Zhai, Guangju, Zhao, Jing Hua, Aschard, Hugues, Burkart, Kristin M, Curjuric, Ivan, Eijgelsheim, Mark, Elliott, Paul, Gu, Xiangjun, Harris, Tamara B, Janson, Christer, Homuth, Georg, Hysi, Pirro G, Liu, Jason Z, Loehr, Laura R, Lohman, Kurt, Loos, Ruth J F, Manning, Alisa K, Marciante, Kristin D, Obeidat, Ma'en, Postma, Dirkje S, Aldrich, Melinda C, Brusselle, Guy G, Chen, Ting-Hsu, Eiriksdottir, Gudny, Franceschini, Nora, Heinrich, Joachim, Rotter, Jerome I, Wijmenga, Cisca, Williams, O Dale, Bentley, Amy R, Hofman, Albert, Laurie, Cathy C, Lumley, Thomas, Morrison, Alanna C, Joubert, Bonnie R, Rivadeneira, Fernando, Couper, David J, Kritchevsky, Stephen B, Liu, Yongmei, Wjst, Matthias, Wain, Louise V, Vonk, Judith M, Uitterlinden, André G, Rochat, Thierry, Rich, Stephen S, Psaty, Bruce M, O'Connor, George T, North, Kari E, Mirel, Daniel B, Meibohm, Bernd, Launer, Lenore J, Khaw, Kay-Tee, Hartikainen, Anna-Liisa, Hammond, Christopher J, Gläser, Sven, Marchini, Jonathan, Kraft, Peter, Wareham, Nicholas J, Völzke, Henry, Stricker, Bruno H C, Spector, Timothy D, Probst-Hensch, Nicole M, Jarvis, Deborah, Jarvelin, Marjo-Riitta, Heckbert, Susan R, Gudnason, Vilmundur, Boezen, H Marike, Barr, R Graham, Cassano, Patricia A, Strachan, David P, Fornage, Myriam, Hall, Ian P, Dupuis, Josée, Tobin, Martin D, and London, Stephanie J
- Abstract
Genome-wide association studies have identified numerous genetic loci for spirometic measures of pulmonary function, forced expiratory volume in one second (FEV1), and its ratio to forced vital capacity (FEV1/FVC). Given that cigarette smoking adversely affects pulmonary function, we conducted genome-wide joint meta-analyses (JMA) of single nucleotide polymorphism (SNP) and SNP-by-smoking (ever-smoking or pack-years) associations on FEV1 and FEV1/FVC across 19 studies (total N = 50,047). We identified three novel loci not previously associated with pulmonary function. SNPs in or near DNER (smallest PJMA = 5.00×10−11), HLA-DQB1 and HLA-DQA2 (smallest PJMA = 4.35×10−9), and KCNJ2 and SOX9 (smallest PJMA = 1.28×10−8) were associated with FEV1/FVC or FEV1 in meta-analysis models including SNP main effects, smoking main effects, and SNP-by-smoking (ever-smoking or pack-years) interaction. The HLA region has been widely implicated for autoimmune and lung phenotypes, unlike the other novel loci, which have not been widely implicated. We evaluated DNER, KCNJ2, and SOX9 and found them to be expressed in human lung tissue. DNER and SOX9 further showed evidence of differential expression in human airway epithelium in smokers compared to non-smokers. Our findings demonstrated that joint testing of SNP and SNP-by-environment interaction identified novel loci associated with complex traits that are missed when considering only the genetic main effects.
- Published
- 2012
- Full Text
- View/download PDF
11. Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function
- Author
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Hancock, Dana B., primary, Artigas, María Soler, additional, Gharib, Sina A., additional, Henry, Amanda, additional, Manichaikul, Ani, additional, Ramasamy, Adaikalavan, additional, Loth, Daan W., additional, Imboden, Medea, additional, Koch, Beate, additional, McArdle, Wendy L., additional, Smith, Albert V., additional, Smolonska, Joanna, additional, Sood, Akshay, additional, Tang, Wenbo, additional, Wilk, Jemma B., additional, Zhai, Guangju, additional, Zhao, Jing Hua, additional, Aschard, Hugues, additional, Burkart, Kristin M., additional, Curjuric, Ivan, additional, Eijgelsheim, Mark, additional, Elliott, Paul, additional, Gu, Xiangjun, additional, Harris, Tamara B., additional, Janson, Christer, additional, Homuth, Georg, additional, Hysi, Pirro G., additional, Liu, Jason Z., additional, Loehr, Laura R., additional, Lohman, Kurt, additional, Loos, Ruth J. F., additional, Manning, Alisa K., additional, Marciante, Kristin D., additional, Obeidat, Ma'en, additional, Postma, Dirkje S., additional, Aldrich, Melinda C., additional, Brusselle, Guy G., additional, Chen, Ting-hsu, additional, Eiriksdottir, Gudny, additional, Franceschini, Nora, additional, Heinrich, Joachim, additional, Rotter, Jerome I., additional, Wijmenga, Cisca, additional, Williams, O. Dale, additional, Bentley, Amy R., additional, Hofman, Albert, additional, Laurie, Cathy C., additional, Lumley, Thomas, additional, Morrison, Alanna C., additional, Joubert, Bonnie R., additional, Rivadeneira, Fernando, additional, Couper, David J., additional, Kritchevsky, Stephen B., additional, Liu, Yongmei, additional, Wjst, Matthias, additional, Wain, Louise V., additional, Vonk, Judith M., additional, Uitterlinden, André G., additional, Rochat, Thierry, additional, Rich, Stephen S., additional, Psaty, Bruce M., additional, O'Connor, George T., additional, North, Kari E., additional, Mirel, Daniel B., additional, Meibohm, Bernd, additional, Launer, Lenore J., additional, Khaw, Kay-Tee, additional, Hartikainen, Anna-Liisa, additional, Hammond, Christopher J., additional, Gläser, Sven, additional, Marchini, Jonathan, additional, Kraft, Peter, additional, Wareham, Nicholas J., additional, Völzke, Henry, additional, Stricker, Bruno H. C., additional, Spector, Timothy D., additional, Probst-Hensch, Nicole M., additional, Jarvis, Deborah, additional, Jarvelin, Marjo-Riitta, additional, Heckbert, Susan R., additional, Gudnason, Vilmundur, additional, Boezen, H. Marike, additional, Barr, R. Graham, additional, Cassano, Patricia A., additional, Strachan, David P., additional, Fornage, Myriam, additional, Hall, Ian P., additional, Dupuis, Josée, additional, Tobin, Martin D., additional, and London, Stephanie J., additional
- Published
- 2012
- Full Text
- View/download PDF
12. Meta-analysis and imputation refines the association of 15q25 with smoking quantity.
- Author
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Liu, Jason Z., Tozzi, Federica, Waterworth, Dawn M., Pillai, Sreekumar G., Muglia, Pierandrea, Middleton, Lefkos, Berrettini, Wade, Knouff, Christopher W., Xin Yuan, Waeber, Gérard, Vollenweider, Peter, Preisig, Martin, Wareham, Nicholas J., Jing Hua Zhao, Loos, Ruth J F., Barroso, Inês, Kay-Tee Khaw, Grundy, Scott, Barter, Philip, and Mahley, Robert
- Subjects
- *
LOCUS (Genetics) , *SMOKING , *TOBACCO use , *LUNG cancer & genetics , *CANCER genetics , *CANCER genes , *GENETICS ,RISK factors ,HEALTH of cigarette smokers - Abstract
Smoking is a leading global cause of disease and mortality. We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association with smoking-related behavioral traits. Our final data set included 41,150 individuals drawn from 20 disease, population and control cohorts. Our analysis confirmed an effect on smoking quantity at a locus on 15q25 (P = 9.45 × 10−19) that includes CHRNA5, CHRNA3 and CHRNB4, three genes encoding neuronal nicotinic acetylcholine receptor subunits. We used data from the 1000 Genomes project to investigate the region using imputation, which allowed for analysis of virtually all common SNPs in the region and offered a fivefold increase in marker density over HapMap2 (ref. 2) as an imputation reference panel. Our fine-mapping approach identified a SNP showing the highest significance, rs55853698, located within the promoter region of CHRNA5. Conditional analysis also identified a secondary locus (rs6495308) in CHRNA3. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF
13. Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function
- Author
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Hancock, Dana B., Artigas, Maria Soler, Gharib, Sina A., Henry, Amanda, Manichaikul, Ani, Ramasamy, Adaikalavan, Loth, Daan W., Imboden, Medea, Koch, Beate, McArdle, Wendy L., Smith, Albert V., Smolonska, Joanna, Sood, Akshay, Tang, Wenbo, Wilk, Jemma B., Zhai, Guangju, Zhao, Jing Hua, Aschard, Hugues, Burkart, Kristin Marie, Curjuric, Ivan, Eijgelsheim, Mark, Elliott, Paul, Gu, Xiangjun, Harris, Tamara B., Janson, Christer, Homuth, Georg, Hysi, Pirro G., Liu, Jason Z., Loehr, Laura R., Lohman, Kurt, Loos, Ruth J. F., Manning, Alisa K., Marciante, Kristin D., Obeidat, Ma’en, Postma, Dirkje S., Aldrich, Melinda C., Brusselle, Guy G., Chen, Ting-Hsu, Eiriksdottir, Gudny, Franceschini, Nora, Heinrich, Joachim, Rotter, Jerome I., Wijmenga, Cisca, Williams, O. Dale, Bentley, Amy R., Hofman, Albert, Laurie, Cathy C., Lumley, Thomas, Morrison, Alanna C., Joubert, Bonnie R., Rivadeneira, Fernando, Couper, David J., Kritchevsky, Stephen B., Liu, Yongmei, Wjst, Matthias, Wain, Louise V., Vonk, Judith M., Uitterlinden, Andre G., Rochat, Thierry, Rich, Stephen S., Psaty, Bruce M., O’Connor, George T., North, Kari E., Mirel, Daniel B., Meibohm, Bernd, Launer, Lenore J., Khaw, Kay-Tee, Hartikainen, Anna-Liisa, Hammond, Christopher J., Glaser, Sven, Marchini, Jonathan, Kraft, Peter, Wareham, Nicholas J., Volzke, Henry, Stricker, Bruno H. C., Spector, Timothy D., Probst-Hensch, Nicole M., Jarvis, Deborah, Jarvelin, Marjo-Riitta, Heckbert, Susan R., Gudnason, Vilmundur, Boezen, H. Marike, Barr, R. Graham, Cassano, Patricia A., Strachan, David P., Fornage, Myriam, Hall, Ian P., Dupuis, Josee, Tobin, Martin D., and London, Stephanie J.
- Subjects
Meta-analysis ,Smoking ,Single nucleotide polymorphisms ,respiratory system ,Lungs ,respiratory tract diseases ,3. Good health - Abstract
Genome-wide association studies have identified numerous genetic loci for spirometic measures of pulmonary function, forced expiratory volume in one second (FEV1), and its ratio to forced vital capacity (FEV1/FVC). Given that cigarette smoking adversely affects pulmonary function, we conducted genome-wide joint meta-analyses (JMA) of single nucleotide polymorphism (SNP) and SNP-by-smoking (ever-smoking or pack-years) associations on FEV1 and FEV1/FVC across 19 studies (total N = 50,047). We identified three novel loci not previously associated with pulmonary function. SNPs in or near DNER (smallest PJMA = 5.00×10−11), HLA-DQB1 and HLA-DQA2 (smallest PJMA = 4.35×10−9), and KCNJ2 and SOX9 (smallest PJMA = 1.28×10−8) were associated with FEV1/FVC or FEV1 in meta-analysis models including SNP main effects, smoking main effects, and SNP-by-smoking (ever-smoking or pack-years) interaction. The HLA region has been widely implicated for autoimmune and lung phenotypes, unlike the other novel loci, which have not been widely implicated. We evaluated DNER, KCNJ2, and SOX9 and found them to be expressed in human lung tissue. DNER and SOX9 further showed evidence of differential expression in human airway epithelium in smokers compared to non-smokers. Our findings demonstrated that joint testing of SNP and SNP-by-environment interaction identified novel loci associated with complex traits that are missed when considering only the genetic main effects.
14. Effect of Immunosuppressive Diseases and Rituximab Infusions on Allowing COVID-19 Infection to Relapse.
- Author
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Prasad RM, Srivastava S, Wang E, Liu JZ, Gami R, Abdelgadir A, Sharma A, Rayamajhi S, and Tikaria R
- Subjects
- COVID-19 Vaccines, Humans, Immunization, Passive, Recurrence, Treatment Outcome, COVID-19 Serotherapy, COVID-19 diagnosis, Immunosuppressive Agents adverse effects, Immunosuppressive Agents therapeutic use, Rituximab adverse effects, Rituximab therapeutic use
- Abstract
Introduction: Relapsing COVID-19 infections have been reported, but their etiology and severity are still unknown. In addition, there have been no cases in the literature that associate relapsing infection with immunosuppression, either from a disease course or medications., Case Presentation: This case series illustrates two patients who developed a relapsed infection, likely from recent rituximab infusions. In addition, both cases depicted a severe form of infection than the initial one. Laboratory investigations revealed these patients were unable to produce COVID-19 antibodies, even though one of the patients received convalescent plasma., Conclusion: Clinicians should be aware of the possibility of relapsing COVID-19, especially in immunosuppressed patients. Because rituximab induces B-cell depletion, it can also decrease the effectiveness of the COVID-19 vaccine. Therefore, these patients should receive the vaccine before their scheduled rituximab infusion.
- Published
- 2021
- Full Text
- View/download PDF
15. Oxidized low-density lipoprotein alters endothelial progenitor cell populations.
- Author
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Cui Y, Narasimhulu CA, Liu L, Li X, Xiao Y, Zhang J, Xie X, Hao H, Liu JZ, He G, Cowan PJ, Cui L, Zhu H, Parthasarathy S, and Liu Z
- Subjects
- Animals, Bone Marrow metabolism, Cells, Cultured, Endothelial Progenitor Cells metabolism, Hyperlipidemias metabolism, Hyperlipidemias pathology, Lipoproteins, LDL pharmacology, Male, Mice, Inbred C57BL, Reactive Oxygen Species metabolism, Endothelial Progenitor Cells cytology, Lipoproteins, LDL metabolism
- Abstract
Oxidized low-density lipoprotein (ox-LDL) is critical to atherosclerosis in hyperlipidemia. Bone marrow (BM)-derived endothelial progenitor cells (EPCs) are important to preventing atherosclerosis, and significantly decreased in hyperlipidemia. This study was to demonstrate ox-LDL and hyperlipidemia could exhibit similar effect on EPC population and the role of reactive oxygen species (ROS). ROS production in BM and blood was significantly increased in male C57BL/6 mice with intravenous ox-LDL treatment, and in hyperlipidemic LDL receptor knockout mice with 4-month high-fat diet. ROS formation was effectively blocked with overexpression of antioxidant enzymes or N-acetylcysteine treatment. In hyperlipidemic and ox-LDL-treated mice, c-Kit(+)/CD31(+) cell number in BM and blood, and Sca-1(+)/Flk-1(+) cell number in blood, not in BM, were significantly decreased, which were not affected by inhibiting ROS production, while blood CD34(+)/Flk-1(+) cell number was significantly increased that was prevented with reduced ROS formation. However, blood CD34(+)/CD133(+) cell number increased in ox-LDL-treated mice, while decreased in hyperlipidemic mice. These data suggested that ox-LDL produced significant changes in BM and blood EPC populations similar (but not identical) to chronic hyperlipidemia with predominantly ROS-independent mechanism(s).
- Published
- 2015
- Full Text
- View/download PDF
16. Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function.
- Author
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Soler Artigas M, Wain LV, Repapi E, Obeidat M, Sayers I, Burton PR, Johnson T, Zhao JH, Albrecht E, Dominiczak AF, Kerr SM, Smith BH, Cadby G, Hui J, Palmer LJ, Hingorani AD, Wannamethee SG, Whincup PH, Ebrahim S, Smith GD, Barroso I, Loos RJ, Wareham NJ, Cooper C, Dennison E, Shaheen SO, Liu JZ, Marchini J, Dahgam S, Naluai AT, Olin AC, Karrasch S, Heinrich J, Schulz H, McKeever TM, Pavord ID, Heliövaara M, Ripatti S, Surakka I, Blakey JD, Kähönen M, Britton JR, Nyberg F, Holloway JW, Lawlor DA, Morris RW, James AL, Jackson CM, Hall IP, and Tobin MD
- Subjects
- Adult, Aged, Europe epidemiology, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Glutathione Transferase genetics, Humans, Male, Microfilament Proteins genetics, Middle Aged, Polymorphism, Single Nucleotide, Receptor for Advanced Glycation End Products, Receptors, Immunologic genetics, Receptors, Serotonin, 5-HT4 genetics, Tensins, Thrombospondin 1 genetics, Forced Expiratory Volume genetics, Genetic Variation, Pulmonary Disease, Chronic Obstructive epidemiology, Pulmonary Disease, Chronic Obstructive genetics, Vital Capacity genetics
- Abstract
Rationale: Genomic loci are associated with FEV1 or the ratio of FEV1 to FVC in population samples, but their association with chronic obstructive pulmonary disease (COPD) has not yet been proven, nor have their combined effects on lung function and COPD been studied., Objectives: To test association with COPD of variants at five loci (TNS1, GSTCD, HTR4, AGER, and THSD4) and to evaluate joint effects on lung function and COPD of these single-nucleotide polymorphisms (SNPs), and variants at the previously reported locus near HHIP., Methods: By sampling from 12 population-based studies (n = 31,422), we obtained genotype data on 3,284 COPD case subjects and 17,538 control subjects for sentinel SNPs in TNS1, GSTCD, HTR4, AGER, and THSD4. In 24,648 individuals (including 2,890 COPD case subjects and 13,862 control subjects), we additionally obtained genotypes for rs12504628 near HHIP. Each allele associated with lung function decline at these six SNPs contributed to a risk score. We studied the association of the risk score to lung function and COPD., Measurements and Main Results: Association with COPD was significant for three loci (TNS1, GSTCD, and HTR4) and the previously reported HHIP locus, and suggestive and directionally consistent for AGER and TSHD4. Compared with the baseline group (7 risk alleles), carrying 10-12 risk alleles was associated with a reduction in FEV1 (β = -72.21 ml, P = 3.90 × 10(-4)) and FEV1/FVC (β = -1.53%, P = 6.35 × 10(-6)), and with COPD (odds ratio = 1.63, P = 1.46 × 10(-5))., Conclusions: Variants in TNS1, GSTCD, and HTR4 are associated with COPD. Our highest risk score category was associated with a 1.6-fold higher COPD risk than the population average score.
- Published
- 2011
- Full Text
- View/download PDF
17. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
- Author
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Soler Artigas M, Loth DW, Wain LV, Gharib SA, Obeidat M, Tang W, Zhai G, Zhao JH, Smith AV, Huffman JE, Albrecht E, Jackson CM, Evans DM, Cadby G, Fornage M, Manichaikul A, Lopez LM, Johnson T, Aldrich MC, Aspelund T, Barroso I, Campbell H, Cassano PA, Couper DJ, Eiriksdottir G, Franceschini N, Garcia M, Gieger C, Gislason GK, Grkovic I, Hammond CJ, Hancock DB, Harris TB, Ramasamy A, Heckbert SR, Heliövaara M, Homuth G, Hysi PG, James AL, Jankovic S, Joubert BR, Karrasch S, Klopp N, Koch B, Kritchevsky SB, Launer LJ, Liu Y, Loehr LR, Lohman K, Loos RJ, Lumley T, Al Balushi KA, Ang WQ, Barr RG, Beilby J, Blakey JD, Boban M, Boraska V, Brisman J, Britton JR, Brusselle GG, Cooper C, Curjuric I, Dahgam S, Deary IJ, Ebrahim S, Eijgelsheim M, Francks C, Gaysina D, Granell R, Gu X, Hankinson JL, Hardy R, Harris SE, Henderson J, Henry A, Hingorani AD, Hofman A, Holt PG, Hui J, Hunter ML, Imboden M, Jameson KA, Kerr SM, Kolcic I, Kronenberg F, Liu JZ, Marchini J, McKeever T, Morris AD, Olin AC, Porteous DJ, Postma DS, Rich SS, Ring SM, Rivadeneira F, Rochat T, Sayer AA, Sayers I, Sly PD, Smith GD, Sood A, Starr JM, Uitterlinden AG, Vonk JM, Wannamethee SG, Whincup PH, Wijmenga C, Williams OD, Wong A, Mangino M, Marciante KD, McArdle WL, Meibohm B, Morrison AC, North KE, Omenaas E, Palmer LJ, Pietiläinen KH, Pin I, Pola Sbreve Ek O, Pouta A, Psaty BM, Hartikainen AL, Rantanen T, Ripatti S, Rotter JI, Rudan I, Rudnicka AR, Schulz H, Shin SY, Spector TD, Surakka I, Vitart V, Völzke H, Wareham NJ, Warrington NM, Wichmann HE, Wild SH, Wilk JB, Wjst M, Wright AF, Zgaga L, Zemunik T, Pennell CE, Nyberg F, Kuh D, Holloway JW, Boezen HM, Lawlor DA, Morris RW, Probst-Hensch N, Kaprio J, Wilson JF, Hayward C, Kähönen M, Heinrich J, Musk AW, Jarvis DL, Gläser S, Järvelin MR, Ch Stricker BH, Elliott P, O'Connor GT, Strachan DP, London SJ, Hall IP, Gudnason V, and Tobin MD
- Subjects
- Child, Humans, Pulmonary Disease, Chronic Obstructive genetics, Pulmonary Disease, Chronic Obstructive physiopathology, White People, Genome-Wide Association Study, Respiratory Function Tests
- Abstract
Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 × 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.
- Published
- 2011
- Full Text
- View/download PDF
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