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3. Children with chronic myeloid leukaemia treated with front-line imatinib have a slower molecular response and comparable survival compared with adults: a multicenter experience in Taiwan

Author

Liu, Hsi-Che, Kuo, Ming-Chung, Wu, Kang-Hsi, Chen, Tsai-Yun, Chen, Jiann-Shiuh, Wang, Ming-Chung, Lin, Tung-Liang, Yang, YoungSen, Ma, Ming-Chun, Wang, Po-Nan, Sheen, Jiunn-Ming, Wang, Shih-Chung, Chen, Shih-Hsiang, Jaing, Tang-Her, Cheng, Chao-Neng, Yeh, Ting-Chi, Lin, Tung-Huei, and Shih, Lee-Yung

Published
2023
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4. Characteristics and outcomes of second cancers in patients with childhood cancer: A report from the Taiwan Pediatric Oncology Group

Author

Ho, Wan-Ling, Hung, Giun-Yi, Yen, Hsiu-Ju, Yang, Yung-Li, Chang, Hsiu-Hao, Lu, Meng-Yao, Lin, Kai-Hsin, Chen, Jiann-Shiuh, Cheng, Chao-Neng, Hung, Iou-Jih, Yang, Chao-Ping, Chen, Shih-Hsiang, Liu, Hsi-Che, Yeh, Ting-Chi, Hou, Jen-Yin, Hsiao, Chih-Cheng, Sheen, Jiunn-Ming, Chang, Tai-Tsung, Wong, Tai-Tong, Miser, James S., Liu, Yen-Lin, Chen, Rong-Long, Chen, Bow-Wen, Peng, Ching-Tien, Chang, Te-Kau, Wu, Kang-Hsi, Chang, Yu-Hsiang, Wang, Jinn-Li, Wang, Shih-Chung, Lin, Ming-Tsan, Hu, Fu-Chang, Jou, Shiann-Tarng, and Lin, Dong-Tsamn

Published
2022
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5. EBV-driven lymphoid neoplasms associated with pediatric ALL maintenance therapy

Author

Elitzur, Sarah, Vora, Ajay, Burkhardt, Birgit, Inaba, Hiroto, Attarbaschi, Andishe, Baruchel, Andre, Escherich, Gabriele, Gibson, Brenda, Liu, Hsi-Che, Loh, Mignon, Moorman, Anthony V., Moricke, Anja, Pieters, Rob, Uyttebroeck, Anne, Baird, Susan, Bartram, Jack, Barzilai-Birenboim, Shlomit, Batra, Sandeep, Ben-Harosh, Miriam, Bertrand, Yves, Buitenkamp, Trudy, Caldwell, Kenneth, Drut, Ricardo, Geerlinks, Ashley V., Gilad, Gil, Grainger, John, Haouy, Stephanie, Heaney, Nicholas, Huang, Mary, Ingham, Danielle, Krenova, Zdenka, Kuhlen, Michaela, Lehrnbecher, Thomas, Manabe, Atsushi, Niggli, Felix, Paris, Claudia, Revel-Vilk, Shoshana, Rohrlich, Pierre, Sinno, Mohamad G., Szczepanski, Tomasz, Tamesberger, Melanie, Warrier, Rajasekharan, Wolfl, Matthias, Nirel, Ronit, Izraeli, Shai, Borkhardt, Arndt, and Schmiegelow, Kjeld

Published
2022
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6. Refining risk stratification in paediatric B‐acute lymphoblastic leukaemia: Combining IKZF1plus and Day 15 MRD positivity

Author

Liu, Hsi‐Che, primary, Huang, Ying‐Jung, additional, Jaing, Tang‐Her, additional, Wu, Kang‐Hsi, additional, Chen, Shih‐Hsiang, additional, Wang, Shih‐Chung, additional, Yeh, Ting‐Chi, additional, Hsiao, Chih‐Cheng, additional, Chang, Te‐Kau, additional, Yen, Hsiu‐Ju, additional, Huang, Fang‐Liang, additional, Lin, Pei‐Chin, additional, Hou, Jen‐Yin, additional, Sheen, Jiunn‐Ming, additional, Liao, Yu‐Mei, additional, Chang, Tsung‐Yen, additional, Chen, Yu‐Chieh, additional, Chiou, Shyh‐Shin, additional, Yang, Chao‐Ping, additional, Pui, Ching‐Hon, additional, Liang, Der‐Cherng, additional, and Shih, Lee‐Yung, additional

Published
2024
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7. Treatment outcomes of pediatric acute myeloid leukemia: a retrospective analysis from 1996 to 2019 in Taiwan

Author

Yang, Yung-Li, Jaing, Tang-Her, Chen, Shih-Hsiang, Liu, Hsi-Che, Hung, Iou-Jih, Lin, Dong-Tsamn, Yang, Chao-Ping, Peng, Ching-Tien, Lin, Kai-Hsin, Hsiao, Chih-Cheng, Jou, Shiann-Tarng, Chen, Jiann-Shiuh, Lin, Ming-Tsan, Wang, Shih-Chung, Chang, Te-Kau, Huang, Fang-Liang, Cheng, Chao-Neng, Wu, Kang-Hsi, Sheen, Jiunn-Ming, Chen, Shu-Huey, Lu, Meng-Yao, Hung, Giun-Yi, Yen, Hsiu-Ju, Hsieh, Yuh-Lin, Wang, Jinn-Li, Chang, Yu-Hsiang, Chang, Hsiu-Hao, Yeh, Ting-Chi, Weng, Te-Fu, Hou, Jen-Yin, Chen, Bow-Wen, Chen, Rong-Long, Wang, Lin-Yen, Ho, Wan-Ling, Chen, Yu-Chieh, Cheng, Shin-Nan, Chao, Yu-Hua, Yang, Shang-Hsien, Huang, Ting-Huan, Chou, Shu-Wei, Lin, Chien-Yu, Chen, Hsuan-Yu, Chao, Yu-Mei Y., Liang, Der-Cherng, and Chang, Tai-Tsung

Published
2021
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9. Refining risk stratification in paediatric B‐acute lymphoblastic leukaemia: Combining IKZF1plus and Day 15 MRD positivity.

Author

Liu, Hsi‐Che, Huang, Ying‐Jung, Jaing, Tang‐Her, Wu, Kang‐Hsi, Chen, Shih‐Hsiang, Wang, Shih‐Chung, Yeh, Ting‐Chi, Hsiao, Chih‐Cheng, Chang, Te‐Kau, Yen, Hsiu‐Ju, Huang, Fang‐Liang, Lin, Pei‐Chin, Hou, Jen‐Yin, Sheen, Jiunn‐Ming, Liao, Yu‐Mei, Chang, Tsung‐Yen, Chen, Yu‐Chieh, Chiou, Shyh‐Shin, Yang, Chao‐Ping, and Pui, Ching‐Hon

Subjects
*LYMPHOBLASTIC leukemia, *ACUTE leukemia, *OPTIMISM, *OVERALL survival, *PEDIATRICS
Abstract

Summary: This study investigates the potential utility of IKZF1 deletion as an additional high‐risk marker for paediatric acute lymphoblastic leukaemia (ALL). The prognostic impact of IKZF1 status, in conjunction with minimal/measurable residual disease (MRD), was evaluated within the MRD‐guided TPOG‐ALL‐2013 protocol using 412 newly diagnosed B‐ALL patients aged 1–18. IKZF1 status was determined using multiplex ligation‐dependent probe amplification. IKZF1 deletions, when co‐occurring with CDKN2A, CDKN2B, PAX5 or PAR1 region deletions in the absence of ERG deletions, were termed IKZF1plus. Both IKZF1 deletion (14.6%) and IKZF1plus (7.8%) independently predicted poorer outcomes in B‐ALL. IKZF1plus was observed in 4.1% of Philadelphia‐negative ALL, with a significantly lower 5‐year event‐free survival (53.9%) compared to IKZF1 deletion alone (83.8%) and wild‐type IKZF1 (91.3%) (p < 0.0001). Among patients with Day 15 MRD ≥0.01%, provisional high‐risk patients with IKZF1plus exhibited the worst outcomes in event‐free survival (42.0%), relapse‐free survival (48.0%) and overall survival (72.7%) compared to other groups (p < 0.0001). Integration of IKZF1plus and positive Day 15 MRD identified a subgroup of Philadelphia‐negative B‐ALL with a 50% risk of relapse. This study highlights the importance of assessing IKZF1plus alongside Day 15 MRD positivity to identify patients at increased risk of adverse outcomes, potentially minimizing overtreatment. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Application of Drug Testing Platforms in Circulating Tumor Cells and Validation of a Patient-Derived Xenograft Mouse Model in Patient with Primary Intracranial Ependymomas with Extraneural Metastases

Author

Liang, Muh-Lii, primary, Yeh, Ting-Chi, additional, Huang, Man-Hsu, additional, Wu, Pao-Shu, additional, Wu, Shih-Pei, additional, Huang, Chun-Chao, additional, Yen, Tsung-Yu, additional, Ting, Wei-Hsin, additional, Hou, Jen-Yin, additional, Huang, Jia-Yun, additional, Ding, Yi-Huei, additional, Zheng, Jia-Huei, additional, Liu, Hsi-Che, additional, Ho, Che-Sheng, additional, Chen, Shiu-Jau, additional, and Hsieh, Tsung-Han, additional

Published
2023
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14. EBV-driven lymphoid neoplasms associated with pediatric ALL maintenance therapy

Author

Elitzur, Sarah, Vora, Ajay, Burkhardt, Birgit, Inaba, Hiroto, Attarbaschi, Andishe, Baruchel, Andre, Escherich, Gabriele, Gibson, Brenda, Liu, Hsi Che, Loh, Mignon, Moorman, Anthony V., Möricke, Anja, Pieters, Rob, Uyttebroeck, Anne, Baird, Susan, Bartram, Jack, Barzilai-Birenboim, Shlomit, Batra, Sandeep, Ben-Harosh, Miriam, Bertrand, Yves, Buitenkamp, Trudy, Caldwell, Kenneth, Drut, Ricardo, Geerlinks, Ashley V., Gilad, Gil, Grainger, John, Haouy, Stephanie, Heaney, Nicholas, Huang, Mary, Ingham, Danielle, Krenova, Zdenka, Kuhlen, Michaela, Lehrnbecher, Thomas, Manabe, Atsushi, Niggli, Felix, Paris, Claudia, Revel-Vilk, Shoshana, Rohrlich, Pierre, Sinno, Mohamad G., Szczepanski, Tomasz, Tamesberger, Melanie, Warrier, Rajasekharan, Wolfl, Matthias, Nirel, Ronit, Izraeli, Shai, Borkhardt, Arndt, Schmiegelow, Kjeld, Elitzur, Sarah, Vora, Ajay, Burkhardt, Birgit, Inaba, Hiroto, Attarbaschi, Andishe, Baruchel, Andre, Escherich, Gabriele, Gibson, Brenda, Liu, Hsi Che, Loh, Mignon, Moorman, Anthony V., Möricke, Anja, Pieters, Rob, Uyttebroeck, Anne, Baird, Susan, Bartram, Jack, Barzilai-Birenboim, Shlomit, Batra, Sandeep, Ben-Harosh, Miriam, Bertrand, Yves, Buitenkamp, Trudy, Caldwell, Kenneth, Drut, Ricardo, Geerlinks, Ashley V., Gilad, Gil, Grainger, John, Haouy, Stephanie, Heaney, Nicholas, Huang, Mary, Ingham, Danielle, Krenova, Zdenka, Kuhlen, Michaela, Lehrnbecher, Thomas, Manabe, Atsushi, Niggli, Felix, Paris, Claudia, Revel-Vilk, Shoshana, Rohrlich, Pierre, Sinno, Mohamad G., Szczepanski, Tomasz, Tamesberger, Melanie, Warrier, Rajasekharan, Wolfl, Matthias, Nirel, Ronit, Izraeli, Shai, Borkhardt, Arndt, and Schmiegelow, Kjeld

Abstract

The development of a second malignancy after the diagnosis of childhood acute lymphoblastic leukemia (ALL) is a rare event. Certain second malignancies have been linked with specific elements of leukemia therapy, yet the etiology of most second neoplasms remains obscure and their optimal management strategies are unclear. This is a first comprehensive report of non-Hodgkin lymphomas (NHL) following pediatric ALL therapy, excluding stem-cell transplantation. We analyzed data of patients who developed NHL following ALL diagnosis and were enrolled in 12 collaborative pediatric ALL trials between 1980-2018. Eighty-five patients developed NHL, with mature B-cell lymphoproliferations as the dominant subtype (56 of 85 cases). Forty-six of these 56 cases (82%) occurred during or within 6 months of maintenance therapy. The majority exhibited histopathological characteristics associated with immunodeficiency (65%), predominantly evidence of Epstein-Barr virus–driven lymphoproliferation. We investigated 66 cases of post-ALL immunodeficiency-associated lymphoid neoplasms, 52 from our study and 14 additional cases from a literature search. With a median follow-up of 4.9 years, the 5-year overall survival for the 66 patients with immunodeficiency-associated lymphoid neoplasms was 67.4% (95% confidence interval [CI], 56-81). Five-year cumulative risks of lymphoid neoplasm– and leukemia-related mortality were 20% (95% CI, 10.2-30) and 12.4% (95% CI, 2.7-22), respectively. Concurrent hemophagocytic lymphohistiocytosis was associated with increased mortality (hazard ratio, 7.32; 95% CI, 1.62-32.98; P =.01). A large proportion of post-ALL lymphoid neoplasms are associated with an immunodeficient state, likely precipitated by ALL maintenance therapy. Awareness of this underrecognized entity and pertinent diagnostic tests are crucial for early diagnosis and optimal therapy.

Published
2023

15. EBV-driven lymphoid neoplasms associated with pediatric ALL maintenance therapy

Author

Elitzur, Sarah, primary, Vora, Ajay, additional, Burkhardt, Birgit, additional, Inaba, Hiroto, additional, Attarbaschi, Andishe, additional, Baruchel, Andre, additional, Escherich, Gabriele, additional, Gibson, Brenda, additional, Liu, Hsi-Che, additional, Loh, Mignon, additional, Moorman, Anthony V., additional, Möricke, Anja, additional, Pieters, Rob, additional, Uyttebroeck, Anne, additional, Baird, Susan, additional, Bartram, Jack, additional, Barzilai-Birenboim, Shlomit, additional, Batra, Sandeep, additional, Ben-Harosh, Miriam, additional, Bertrand, Yves, additional, Buitenkamp, Trudy, additional, Caldwell, Kenneth, additional, Drut, Ricardo, additional, Geerlinks, Ashley V., additional, Gilad, Gil, additional, Grainger, John, additional, Haouy, Stephanie, additional, Heaney, Nicholas, additional, Huang, Mary, additional, Ingham, Danielle, additional, Krenova, Zdenka, additional, Kuhlen, Michaela, additional, Lehrnbecher, Thomas, additional, Manabe, Atsushi, additional, Niggli, Felix, additional, Paris, Claudia, additional, Revel-Vilk, Shoshana, additional, Rohrlich, Pierre, additional, Sinno, Mohamad G., additional, Szczepanski, Tomasz, additional, Tamesberger, Melanie, additional, Warrier, Rajasekharan, additional, Wolfl, Matthias, additional, Nirel, Ronit, additional, Izraeli, Shai, additional, Borkhardt, Arndt, additional, and Schmiegelow, Kjeld, additional

Published
2023
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19. Can Machine Learning Models Predict Asparaginase-associated Pancreatitis in Childhood Acute Lymphoblastic Leukemia

Author

Nielsen, Rikke L., Wolthers, Benjamin O., Helenius, Marianne, Albertsen, Birgitte K., Clemmensen, Line, Nielsen, Kasper, Kanerva, Jukka, Niinimäki, Riitta, Frandsen, Thomas L., Attarbaschi, Andishe, Barzilai, Shlomit, Colombini, Antonella, Escherich, Gabriele, Aytan-Aktug, Derya, Liu, Hsi Che, Möricke, Anja, Samarasinghe, Sujith, Van Der Sluis, Inge M., Stanulla, Martin, Tulstrup, Morten, Yadav, Rachita, Zapotocka, Ester, Schmiegelow, Kjeld, Gupta, Ramneek, Nielsen, Rikke L., Wolthers, Benjamin O., Helenius, Marianne, Albertsen, Birgitte K., Clemmensen, Line, Nielsen, Kasper, Kanerva, Jukka, Niinimäki, Riitta, Frandsen, Thomas L., Attarbaschi, Andishe, Barzilai, Shlomit, Colombini, Antonella, Escherich, Gabriele, Aytan-Aktug, Derya, Liu, Hsi Che, Möricke, Anja, Samarasinghe, Sujith, Van Der Sluis, Inge M., Stanulla, Martin, Tulstrup, Morten, Yadav, Rachita, Zapotocka, Ester, Schmiegelow, Kjeld, and Gupta, Ramneek

Abstract

Asparaginase-associated pancreatitis (AAP) frequently affects children treated for acute lymphoblastic leukemia (ALL) causing severe acute and persisting complications. Known risk factors such as asparaginase dosing, older age and single nucleotide polymorphisms (SNPs) have insufficient odds ratios to allow personalized asparaginase therapy. In this study, we explored machine learning strategies for prediction of individual AAP risk. We integrated information on age, sex, and SNPs based on Illumina Omni2.5exome-8 arrays of patients with childhood ALL (N=1564, 244 with AAP aged 1.0 to 17.9 y) from 10 international ALL consortia into machine learning models including regression, random forest, AdaBoost and artificial neural networks. A model with only age and sex had area under the receiver operating characteristic curve (ROC-AUC) of 0.62. Inclusion of 6 pancreatitis candidate gene SNPs or 4 validated pancreatitis SNPs boosted ROC-AUC somewhat (0.67) while 30 SNPs, identified through our AAP genome-wide association study cohort, boosted performance (0.80). Most predictive features included rs10273639 (PRSS1-PRSS2), rs10436957 (CTRC), rs13228878 (PRSS1/PRSS2), rs1505495 (GALNTL6), rs4655107 (EPHB2) and age (1 to 7 y). Second AAP following asparaginase re-exposure was predicted with ROC-AUC: 0.65. The machine learning models assist individual-level risk assessment of AAP for future prevention trials, and may legitimize asparaginase re-exposure when AAP risk is predicted to be low.

Published
2022

20. Treatment for childhood acute lymphoblastic leukemia in Taiwan: Taiwan Pediatric Oncology Group ALL‐2002 study emphasizing optimal reinduction therapy and central nervous system preventive therapy without cranial radiation

Author

Li, Meng‐Ju, Liu, Hsi‐Che, Yen, Hsiu‐Ju, Jaing, Tang‐Her, Lin, Dong‐Tsamn, Yang, Chao‐Ping, Lin, Kai‐Hsin, Hung, Iou‐Jih, Jou, Shiann‐Tarng, Lu, Meng‐Yao, Hsiao, Chih‐Cheng, Peng, Ching‐Tien, Chang, Tai‐Tsung, Wang, Shih‐Chung, Lin, Ming‐Tsan, Chen, Jiann‐Shiuh, Chang, Te‐Kau, Hung, Giun‐Yi, Wu, Kang‐Hsi, Yang, Yung‐Li, Chang, Hsiu‐Hao, Chen, Shih‐Hsiang, Yeh, Ting‐Chi, Cheng, Chao‐Neng, Lin, Pei‐Chin, Chiou, Shyh‐Shin, Sheen, Jiunn‐Ming, Cheng, Shin‐Nan, Chen, Shu‐Huey, Chang, Yu‐Hsiang, Ho, Wan‐Ling, Chao, Yu‐Hua, Chen, Rong‐Long, Chen, Bow‐Wen, Wang, Jinn‐Li, Hsieh, Yuh‐Lin, Liao, Yu‐Mei, Yang, Shang‐Hsien, Chang, Wan‐Hui, Chao, Yu‐Mei Y., and Liang, Der‐Cherng

Published
2017
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21. Remission, treatment failure, and relapse in pediatric ALL: an international consensus of the Ponte-di-Legno Consortium

Author

Buchmann, Swantje, Schrappe, Martin, Baruchel, Andre, Biondi, Andrea, Borowitz, Michael, Campbell, Myriam, Cario, Gunnar, Cazzaniga, Giovanni, Escherich, Gabriele, Harrison, Christine J., Heyman, Mats, Hunger, Stephen P., Kiss, Csongor, Liu, Hsi-Che, Locatelli, Franco, Loh, Mignon L., Manabe, Atsushi, Mann, Georg, Pieters, Rob, Pui, Ching-Hon, Rives, Susana, Schmiegelow, Kjeld, Silverman, Lewis B., Stary, Jan, Vora, Ajay, and Brown, Patrick

Published
2022
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23. Outcomes Following Discontinuation of E. coli l-Asparaginase Upon Severe Allergic Reactions in Children With Acute Lymphoblastic Leukemia

Author

Yen, Hsiu-Ju, Chang, Wan-Hui, Liu, Hsi-Che, Yeh, Ting-Chi, Hung, Giun-Yi, Wu, Kang-Hsi, Peng, Ching-Tien, Chang, Yu-Hsiang, Chang, Te-Kao, Hsiao, Chih-Cheng, Sheen, Jiunn-Ming, Chao, Yu-Hua, Chang, Tai-Tsung, Chiou, Shyh-Shin, Lin, Pei-Chin, Wang, Shih-Chung, Lin, Ming-Tsan, Ho, Wan-Ling, Chen, Yu-Chieh, and Liang, Der-Cherng

Published
2016
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24. Surgical treatment confers prognostic significance in pediatric malignant mediastinal germ cell tumors.

Author

Huang, Ting‐Huan, Hung, Giun‐Yi, Weng, Te‐Fu, Wang, Fu‐Mien, Lee, Chih‐Ying, Lin, Dong‐Tsamn, Chen, Bow‐Wen, Lin, Kai‐Hsin, Wu, Kang‐Hsi, Liu, Hsi‐Che, Chen, Jiann‐Shiuh, Jou, Shiann‐Tarng, Hou, Jen‐Yin, Yang, Yung‐Li, Chen, Shih‐Hsiang, Chang, Hsiu‐Hao, Chiou, Shyh‐Shin, Lin, Pei‐Chin, Chen, Rong‐Long, and Hsiao, Chih‐Cheng

Subjects
GERM cell tumors, PEDIATRIC oncology, YOLK sac, TREATMENT effectiveness, PROGNOSIS, CHORIOCARCINOMA
Abstract

Background: Primary malignant mediastinal germ cell tumors (GCTs) are rare pediatric tumors that have a poorer prognosis compared to GCTs occurring elsewhere in the body. The current study aimed to assess the prognostic factors and treatment outcomes of children with primary malignant mediastinal GCT in Taiwan. Methods: The authors retrospectively reviewed children 0–18 years old who were newly diagnosed with primary malignant mediastinal GCT between January 1, 2005 and December 31, 2019 and were registered in the Taiwan Pediatric Oncology Group patient registry. The impact of presenting characteristics, including sex, age, tumor stage, histology subtype, surgical treatment, and chemotherapy regimens of the patients were analyzed. Results: This study enrolled 52 children with malignant mediastinal GCT who had a median age of 16.0 (range, 6.0–17.9) years at diagnosis. The most common histological subtypes were mixed GCTs (n = 20) and yolk sac tumors (n = 15). Advanced disease stage and choriocarcinoma histology subtype were associated inferior outcomes. Children who received surgical treatment exhibited better outcomes compared to those who did not (5‐year overall survival, 78% vs. 7%, p <.001). After comparing patients who received first‐line cisplatin‐ and carboplatin‐based chemotherapy, no difference in treatment outcomes was observed. Multivariate analysis showed that surgical management was the only independent predictor for superior OS. Conclusions: Surgical treatment is recommended for mediastinal GCT. Cisplatin‐based chemotherapy was not superior to carboplatin‐based chemotherapy as first‐line treatment and may be avoided due to toxicity concerns. Surgical treatment is recommended for pediatric malignant mediastinal germ cell tumors. Cisplatin‐based chemotherapy was not superior to carboplatin‐based chemotherapy as first‐line treatment. [ABSTRACT FROM AUTHOR]

Published
2022
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25. Comparison of Two Quantitative PCR–Based Assays for Detection of Minimal Residual Disease in B-Precursor Acute Lymphoblastic Leukemia Harboring Three Major Fusion Transcripts

Author

Huang, Ying-Jung, primary, Kuo, Ming-Chung, additional, Jaing, Tang-Her, additional, Liu, Hsi-Che, additional, Yeh, Ting-Chi, additional, Chen, Shih-Hsiang, additional, Lin, Tung-Liang, additional, Yang, Chao-Ping, additional, Wang, Po-Nan, additional, Sheen, Jiunn-Ming, additional, Chang, Te-Kau, additional, Chang, Chia-Hui, additional, Hu, Shu-Fen, additional, Huang, Ting-Yu, additional, Wang, Shih-Chung, additional, Wu, Kang-Hsi, additional, Chiou, Shyh-Shin, additional, Hsiao, Chih-Cheng, additional, and Shih, Lee-Yung, additional

Published
2021
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26. Can Machine Learning Models Predict Asparaginase-associated Pancreatitis in Childhood Acute Lymphoblastic Leukemia

Author

Nielsen, Rikke L., primary, Wolthers, Benjamin O., additional, Helenius, Marianne, additional, Albertsen, Birgitte K., additional, Clemmensen, Line, additional, Nielsen, Kasper, additional, Kanerva, Jukka, additional, Niinimäki, Riitta, additional, Frandsen, Thomas L., additional, Attarbaschi, Andishe, additional, Barzilai, Shlomit, additional, Colombini, Antonella, additional, Escherich, Gabriele, additional, Aytan-Aktug, Derya, additional, Liu, Hsi-Che, additional, Möricke, Anja, additional, Samarasinghe, Sujith, additional, van der Sluis, Inge M., additional, Stanulla, Martin, additional, Tulstrup, Morten, additional, Yadav, Rachita, additional, Zapotocka, Ester, additional, Schmiegelow, Kjeld, additional, and Gupta, Ramneek, additional

Published
2021
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29. Characteristics and outcomes of second cancers in patients with childhood cancer: A report from the Taiwan Pediatric Oncology Group

Author

Ho, Wan-Ling, primary, Hung, Giun-Yi, additional, Yen, Hsiu-Ju, additional, Yang, Yung-Li, additional, Chang, Hsiu-Hao, additional, Lu, Meng-Yao, additional, Lin, Kai-Hsin, additional, Chen, Jiann-Shiuh, additional, Cheng, Chao-Neng, additional, Hung, Iou-Jih, additional, Yang, Chao-Ping, additional, Chen, Shih-Hsiang, additional, Liu, Hsi-Che, additional, Yeh, Ting-Chi, additional, Hou, Jen-Yin, additional, Hsiao, Chih-Cheng, additional, Sheen, Jiunn-Ming, additional, Chang, Tai-Tsung, additional, Wong, Tai-Tong, additional, Miser, James S., additional, Liu, Yen-Lin, additional, Chen, Rong-Long, additional, Chen, Bow-Wen, additional, Peng, Ching-Tien, additional, Chang, Te-Kau, additional, Wu, Kang-Hsi, additional, Chang, Yu-Hsiang, additional, Wang, Jinn-Li, additional, Wang, Shih-Chung, additional, Lin, Ming-Tsan, additional, Hu, Fu-Chang, additional, Jou, Shiann-Tarng, additional, and Lin, Dong-Tsamn, additional

Published
2021
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30. The Different Impacts of an MRD-Guided Protocol on Relapse of Childhood Acute Lymphoblastic Leukemia: The Report of Taiwan Pediatric Oncology Group (TPOG)-ALL-2013

Author

Liu, Hsi-Che, Jou, Shiann-Tarng, Chen, Shih-Hsiang, Jaing, Tang-Her, Yeh, Ting-Chi, Chen, Jiann-Shiuh, Wu, Kang-Hsi, Wang, Shih-Chung, Hsiao, Chih-Cheng, Chang, Te-Kau, Lu, Meng-Yao, Yen, Hsiu-Ju, Huang, Fang-Liang, Chen, Shu-Huey, Yang, Shang-Hsien, Liu, Yen-Lin, Chiou, Shyh-Shin, Yang, Chao-Ping, Shih, Lee-Yung, and Lin, Dong-Tsamn

Published
2023
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34. RAS pathway mutation is an added‐value biomarker in pediatric Philadelphia‐negative B‐cell acute lymphoblastic leukemia withIKZF1deletions

Author

Huang, Ying‐Jung, primary, Liu, Hsi‐Che, additional, Jaing, Tang‐Her, additional, Wu, Kang‐Hsi, additional, Wang, Shih‐Chung, additional, Yen, Hsiu‐Ju, additional, Hsiao, Chih‐Cheng, additional, Chen, Shih‐Hsiang, additional, Lin, Pei‐Chin, additional, Yeh, Ting‐Chi, additional, Sheen, Jiunn‐Ming, additional, Chen, Yu‐Chieh, additional, Chang, Te‐Kau, additional, Huang, Fang‐Liang, additional, Chao, Yu‐Hua, additional, Hou, Jen‐Yin, additional, Yang, Chao‐Ping, additional, Lin, Tung‐Huei, additional, and Shih, Lee‐Yung, additional

Published
2021
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35. An international retrospective study for tolerability of 6-mercaptopurine on NUDT15 bi-allelic variants in children with acute lymphoblastic leukemia

Author

Tanaka, Yoichi, primary, Yeoh, Allen Eng Juh, additional, Moriyama, Takaya, additional, Li, Chi-Kong, additional, Kudo, Ko, additional, Arakawa, Yuki, additional, Buaboonnam, Jassada, additional, Zhang, Hui, additional, Liu, Hsi-Che, additional, Ariffin, Hany, additional, Chen, Zhiwei, additional, Kham, Shirley K.Y., additional, Nishii, Rina, additional, Hasegawa, Daisuke, additional, Fujimura, Junya, additional, Keino, Dai, additional, Kondoh, Kensuke, additional, Sato, Atsushi, additional, Ueda, Takahiro, additional, Yamamoto, Masaki, additional, Taneyama, Yuichi, additional, Hino, Moeko, additional, Takagi, Masatoshi, additional, Ohara, Akira, additional, Ito, Etsuro, additional, Koh, Katsuyoshi, additional, Hori, Hiroki, additional, Manabe, Atsushi, additional, Yang, Jun J., additional, and Kato, Motohiro, additional

Published
2021
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37. Parental experiences of educational supports offered during their child's cancer treatment.

Author

Huang, Hsiu‐Mei, Yeh, Ting‐Chi, Liu, Hsi‐Che, and Lee, Tzu‐Ying

Subjects
PARENT attitudes, MOTHERS, SOCIAL support, HAPPINESS, RESEARCH methodology, FATHERS, INTERVIEWING, RE-entry students, TUMORS in children, EXPERIENCE, CANCER patients, QUALITATIVE research, PARENT-child relationships, EDUCATIONAL mobility, THEMATIC analysis
Abstract

Background: To explore how parents of children with cancer offer educational supports during the treatment process. Methods: Based on a descriptive qualitative method design, 29 mothers and 19 fathers of children with cancer were interviewed on their experiences of supporting their child's education during their child's treatment through semi‐structured interviews. Result: Six themes were summarized from the parents' experiences in supporting their child's education during treatment: initial emphasis on survival over education; educational strategies important when returning to everyday life post‐treatment; parents and educators have different expectations; child's extracurricular activities provided a sense of accomplishment; preparing for transition to school; and long‐term concern was for the child's health and happiness. Conclusion: Education is part of children's normal development, but education is often placed on hold for a child receiving cancer treatment. Parents of children with cancer are unable to focus on the child's education because of the threat to their child's life. When their child's illness stabilizes, they will begin to utilize their resources to arrange lessons to facilitate returning to school. Through understanding parents' learning expectations, medical professionals can support adjustments to parents' attitudes. [ABSTRACT FROM AUTHOR]

Published
2022
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44. Efficacy of infantile hepatic hemangioma with propranolol treatment

Author

Tsai, Mu-Chieh, Liu, Hsi-Che, and Yeung, Chun-Yan

Subjects
hemangioma, Adrenergic beta-Antagonists, Liver Neoplasms, Humans, Infant, Female, Clinical Case Report, liver, Propranolol, Research Article
Abstract

Rationale: Hepatic hemangioma is rarely discovered during the infantile period. Although most of the cases are asymptomatic, some of them may suffer life-threatening situations. In this regard, early detection is mandatory for preventing the ominous consequences that might be culminated from the disease. Patient concerns: A 2-month-14-day-old female infant was found incidentally to have multiple hepatic lesions during a newborn ultrasound screen. She was born smoothly at term after a non-eventful pregnancy course. Physical examination was completely normal and postnatal vital signs were stable. Diagnosis: Infantile multiple hepatic hemangiomas. Intervention: High-resolution ultrasound and abdominal computer tomogram were conducted to confirm the diagnosis. Propranolol was started at the age of 3 months and 7 days old with an initial dosage of 1.5 mg/kg per day and increased gradually to 2.5 mg/kg per day. No obvious adverse effects were noted during the treatment course. Rapid clinical improvement with decreasing size was observed by ultrasound 10 days after the treatment. Eventually, hepatic lesions totally disappeared 4.5 months later. Propranolol in dosage of 2.5 mg/kg per day was continued until 6 months after the initial prescription. Outcomes: A period of 11-month follow-up revealed no evidence of recurrence of hemangiomas. Lessons: Early diagnosis and intervention are mandatory for infantile hepatic hemangiomas to prevent possible ominous consequences. Though the propranolol therapy protocol for the disease is still under developing, the current report strengthens the recommendation to use propranolol as the first-line medication for treating infantile hepatic hemangiomas.

Published
2019

46. Gene expression profiling of pediatric acute myelogenous leukemia

Author

Ross, Mary E., Mahfouz, Rami, Onciu, Mihaela, Liu, Hsi-Che, Zhou, Xiaodong, Song, Guangchun, Shurtleff, Sheila A., Pounds, Stanley, Cheng, Cheng, Ma, Jing, Ribeiro, Raul C., Rubnitz, Jeffrey E., Girtman, Kevin, Williams, W. Kent, Raimondi, Susana C., Liang, Der-Cherng, Shih, Lee-Yung, Pui, Ching-Hon, and Downing, James R.

Published
2004
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47. Picture of the Month

Author

Lee, Yann-Jinn, Liu, Hsi-Che, Lee, Hung-Chang, Tzen, Chi-Yuan, Huang, Chi-Yu, and Yang, Tsen-Long

Published
2001

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