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2. Serotonin reduction in post-acute sequelae of viral infection

Author

Wong, Andrea C., Devason, Ashwarya S., Umana, Iboro C., Cox, Timothy O., Dohnalová, Lenka, Litichevskiy, Lev, Perla, Jonathan, Lundgren, Patrick, Etwebi, Zienab, Izzo, Luke T., Kim, Jihee, Tetlak, Monika, Descamps, Hélène C., Park, Simone L., Wisser, Stephen, McKnight, Aaron D., Pardy, Ryan D., Kim, Junwon, Blank, Niklas, Patel, Shaan, Thum, Katharina, Mason, Sydney, Beltra, Jean-Christophe, Michieletto, Michaël F., Ngiow, Shin Foong, Miller, Brittany M., Liou, Megan J., Madhu, Bhoomi, Dmitrieva-Posocco, Oxana, Huber, Alex S., Hewins, Peter, Petucci, Christopher, Chu, Candice P., Baraniecki-Zwil, Gwen, Giron, Leila B., Baxter, Amy E., Greenplate, Allison R., Kearns, Charlotte, Montone, Kathleen, Litzky, Leslie A., Feldman, Michael, Henao-Mejia, Jorge, Striepen, Boris, Ramage, Holly, Jurado, Kellie A., Wellen, Kathryn E., O’Doherty, Una, Abdel-Mohsen, Mohamed, Landay, Alan L., Keshavarzian, Ali, Henrich, Timothy J., Deeks, Steven G., Peluso, Michael J., Meyer, Nuala J., Wherry, E. John, Abramoff, Benjamin A., Cherry, Sara, Thaiss, Christoph A., and Levy, Maayan

Published
2023
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4. Two cases of severe pulmonary toxicity from highly active mesothelin-directed CAR T cells

Author

Haas, Andrew R., Golden, Ryan J., Litzky, Leslie A., Engels, Boris, Zhao, Linlin, Xu, Fangmin, Taraszka, John A., Ramones, Melissa, Granda, Brian, Chang, Wan-Jung, Jadlowsky, Julie, Shea, Kim-Marie, Runkle, Adam, Chew, Anne, Dowd, Emily, Gonzalez, Vanessa, Chen, Fang, Liu, Xiaojun, Fang, Chongyun, Jiang, Shuguang, Davis, Megan M., Sheppard, Neil C., Zhao, Yangbing, Fraietta, Joseph A., Lacey, Simon F., Plesa, Gabriela, Melenhorst, J. Joseph, Mansfield, Keith, Brogdon, Jennifer L., Young, Regina M., Albelda, Steven M., June, Carl H., and Tanyi, Janos L.

Published
2023
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5. Brain metastases in patients with pleural mesothelioma receiving dual checkpoint blockade compared to single-agent checkpoint blockade or chemotherapy.

Author

Stalker, Margaret, primary, Walker, Suzanne, additional, Lebow, Emily S., additional, Anderson, Evan P., additional, Roshkovan, Leonid, additional, Katz, Sharyn I., additional, Litzky, Leslie, additional, Haas, Andrew R., additional, Singhal, Sunil, additional, Langer, Corey J., additional, Cengel, Keith A., additional, and Marmarelis, Melina Elpi, additional

Published
2024
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7. Exposure to Ambient Particulate Matter Is Associated With Accelerated Functional Decline in Idiopathic Pulmonary Fibrosis

Author

Winterbottom, Christopher J, Shah, Rupal J, Patterson, Karen C, Kreider, Maryl E, Panettieri, Reynold A, Rivera-Lebron, Belinda, Miller, Wallace T, Litzky, Leslie A, Penning, Trevor M, Heinlen, Krista, Jackson, Tara, Localio, A Russell, and Christie, Jason D

Subjects
Lung, Digestive Diseases, Autoimmune Disease, Climate-Related Exposures and Conditions, Rare Diseases, Aetiology, 2.2 Factors relating to the physical environment, Respiratory, Sustainable Cities and Communities, Good Health and Well Being, Aged, Aged, 80 and over, Air Pollution, Cohort Studies, Disease Progression, Female, Humans, Idiopathic Pulmonary Fibrosis, Male, Middle Aged, Outcome Assessment, Health Care, Particulate Matter, Time Factors, Vital Capacity, air pollution, environmental pollution, idiopathic pulmonary fibrosis, interstitial lung disease, pulmonary fibrosis, Clinical Sciences, Respiratory System
Abstract

BackgroundIdiopathic pulmonary fibrosis (IPF), a progressive disease with an unknown pathogenesis, may be due in part to an abnormal response to injurious stimuli by alveolar epithelial cells. Air pollution and particulate inhalation of matter evoke a wide variety of pulmonary and systemic inflammatory diseases. We therefore hypothesized that increased average ambient particulate matter (PM) concentrations would be associated with an accelerated rate of decline in FVC in IPF.MethodsWe identified a cohort of subjects seen at a single university referral center from 2007 to 2013. Average concentrations of particulate matter < 10 and < 2.5 μg/m3 (PM10 and PM2.5, respectively) were assigned to each patient based on geocoded residential addresses. A linear multivariable mixed-effects model determined the association between the rate of decline in FVC and average PM concentration, controlling for baseline FVC at first measurement and other covariates.ResultsOne hundred thirty-five subjects were included in the final analysis after exclusion of subjects missing repeated spirometry measurements and those for whom exposure data were not available. There was a significant association between PM10 levels and the rate of decline in FVC during the study period, with each μg/m3 increase in PM10 corresponding with an additional 46 cc/y decline in FVC (P = .008).ConclusionsAmbient air pollution, as measured by average PM10 concentration, is associated with an increase in the rate of decline of FVC in IPF, suggesting a potential mechanistic role for air pollution in the progression of disease.

Published
2018

8. Brief Report: Impact of reflex testing on tissue-based molecular genotyping in patients with advanced non-squamous non-small cell lung cancer

Author

Marmarelis, Melina E., primary, Scholes, Dylan G., additional, McGrath, Cindy M., additional, Priore, Salvatore F., additional, Roth, Jacquelyn J., additional, Feldman, Michael, additional, Morrissette, Jennifer J.D., additional, Litzky, Leslie, additional, Deshpande, Charu, additional, Thompson, Jeffrey C., additional, Doucette, Abigail, additional, Gabriel, Peter E., additional, Sun, Lova, additional, Singh, Aditi P., additional, Cohen, Roger B., additional, Langer, Corey J., additional, Carpenter, Erica L., additional, and Aggarwal, Charu, additional

Published
2024
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10. The concept of mesothelioma in situ, with consideration of its potential impact on cytology diagnosis

Author

Klebe, Sonja, Nakatani, Yukio, Dobra, Katalin, Butnor, Kelly J., Roden, Anja C., Nicholson, Andrew G., Marchevsky, Alberto M., Husain, Aliya N., Segal, Amanda, Walts, Ann E., Weynand, Birgit, Michael, Claire W., Dacic, Sanja, Godbolt, David, Attanoos, Richard, Santoni-Rugiu, Eric, Galateau-Salle, Françoise, Hiroshima, Kenzo, Moreira, Andre L., Burn, Juliet, Nabeshima, Kazuki, Gibbs, Allen R., Churg, Andrew, Litzky, Leslie A., Brcic, Luka, Tsao, Ming Sound, Mino-Kenudson, Mari, Rørvig, Sara B., Tazelaar, Henry D., Krausz, Thomas, Zhang, Yu Zhi, Chirieac, Lucian R., Beasley, Mary B., and Hjerpe, Anders

Published
2021
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13. Nuclear grade and necrosis predict prognosis in malignant epithelioid pleural mesothelioma: a multi-institutional study

Author

Rosen, Lauren E, Karrison, Theodore, Ananthanarayanan, Vijayalakshmi, Gallan, Alexander J, Adusumilli, Prasad S, Alchami, Fouad S, Attanoos, Richard, Brcic, Luka, Butnor, Kelly J, Galateau-Sallé, Françoise, Hiroshima, Kenzo, Kadota, Kyuichi, Klampatsa, Astero, Stang, Nolween Le, Lindenmann, Joerg, Litzky, Leslie A, Marchevsky, Alberto, Medeiros, Filomena, Montero, M Angeles, Moore, David A, Nabeshima, Kazuki, Pavlisko, Elizabeth N, Roggli, Victor L, Sauter, Jennifer L, Sharma, Anupama, Sheaff, Michael, Travis, William D, Vigneswaran, Wickii T, Vrugt, Bart, Walts, Ann E, Tjota, Melissa Y, Krausz, Thomas, and Husain, Aliya N

Published
2018
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14. Supplementary Figures from Function of Human Tumor-Infiltrating Lymphocytes in Early-Stage Non–Small Cell Lung Cancer

Author

O'Brien, Shaun M., primary, Klampatsa, Astero, primary, Thompson, Jeffrey C., primary, Martinez, Marina C., primary, Hwang, Wei-Ting, primary, Rao, Abishek S., primary, Standalick, Jason E., primary, Kim, Soyeon, primary, Cantu, Edward, primary, Litzky, Leslie A., primary, Singhal, Sunil, primary, Eruslanov, Evgeniy B., primary, Moon, Edmund K., primary, and Albelda, Steven M., primary

Published
2023
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15. Data from Function of Human Tumor-Infiltrating Lymphocytes in Early-Stage Non–Small Cell Lung Cancer

Author

O'Brien, Shaun M., primary, Klampatsa, Astero, primary, Thompson, Jeffrey C., primary, Martinez, Marina C., primary, Hwang, Wei-Ting, primary, Rao, Abishek S., primary, Standalick, Jason E., primary, Kim, Soyeon, primary, Cantu, Edward, primary, Litzky, Leslie A., primary, Singhal, Sunil, primary, Eruslanov, Evgeniy B., primary, Moon, Edmund K., primary, and Albelda, Steven M., primary

Published
2023
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16. Supplementary Methods from Function of Human Tumor-Infiltrating Lymphocytes in Early-Stage Non–Small Cell Lung Cancer

Author

O'Brien, Shaun M., primary, Klampatsa, Astero, primary, Thompson, Jeffrey C., primary, Martinez, Marina C., primary, Hwang, Wei-Ting, primary, Rao, Abishek S., primary, Standalick, Jason E., primary, Kim, Soyeon, primary, Cantu, Edward, primary, Litzky, Leslie A., primary, Singhal, Sunil, primary, Eruslanov, Evgeniy B., primary, Moon, Edmund K., primary, and Albelda, Steven M., primary

Published
2023
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17. Supplementary Table 1 from Function of Human Tumor-Infiltrating Lymphocytes in Early-Stage Non–Small Cell Lung Cancer

Author

O'Brien, Shaun M., primary, Klampatsa, Astero, primary, Thompson, Jeffrey C., primary, Martinez, Marina C., primary, Hwang, Wei-Ting, primary, Rao, Abishek S., primary, Standalick, Jason E., primary, Kim, Soyeon, primary, Cantu, Edward, primary, Litzky, Leslie A., primary, Singhal, Sunil, primary, Eruslanov, Evgeniy B., primary, Moon, Edmund K., primary, and Albelda, Steven M., primary

Published
2023
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19. Guidelines for Pathologic Diagnosis of Malignant Mesothelioma: 2017 Update of the Consensus Statement From the International Mesothelioma Interest Group

Author

Husain, Aliya Noor, Colby, Thomas V., Ordonez, Nelson G., Allen, Timothy Craig, Attanoos, Richard Luther, Beasley, Mary Beth, Butnor, Kelly Jo, Chirieac, Lucian R., Churg, Andrew M., Dacic, Sanja, Galateau-Salle, Francoise, Gibbs, Allen, Gown, Allen M., Krausz, Thomas, Litzky, Leslie Anne, Marchevsky, Alberto, Nicholson, Andrew G., Roggli, Victor Louis, Sharma, Anupama K., Travis, William D., Walts, Ann E., and Wick, Mark R.

Subjects
Mesothelioma -- Diagnosis -- Research, Needle biopsy -- Usage, Practice guidelines (Medicine) -- Analysis, Health
Abstract

Context.--Malignant mesothelioma (MM) is an uncommon tumor that can be difficult to diagnose.Objective.--To provide updated, practical guidelines for the pathologic diagnosis of MM.Data Sources.--Pathologists involved in the International Mesothelioma Interest Group and others with an interest and expertise in the field contributed to this update. Reference material included up-to-date, peer-reviewed publications and textbooks.Conclusions.--There was discussion and consensus opinion regarding guidelines for (1) distinguishing benign from malignant mesothelial proliferations (both epithelioid and spindle cell lesions), (2) cytologic diagnosis of MM, (3) recognition of the key histologic features of pleural and peritoneal MM, (4) use of histochemical and immunohistochemical stains in the diagnosis and differential diagnosis of MM, (5) differentiating epithelioid MM from various carcinomas (lung, breast, ovarian, and colonic adenocarcinomas, and squamous cell and renal cell carcinomas), (6) diagnosis of sarcomatoid MM, (7) use of molecular markers in the diagnosis of MM, (8) electron microscopy in the diagnosis of mM, and (9) some caveats and pitfalls in the diagnosis of MM. Immunohistochemical panels are integral to the diagnosis of MM, but the exact makeup of panels employed is dependent on the differential diagnosis and on the antibodies available in a given laboratory. Depending on the morphology, immunohistochemical panels should contain both positive and negative markers for mesothelial differentiation and for lesions considered in the differential diagnosis. Immunohistochemical markers should have either sensitivity or specificity greater than 80% for the lesions in question. Interpretation of positivity generally should take into account the localization of the stain (eg, nuclear versus cytoplasmic) and the percentage of cells staining (>10% is suggested for cytoplasmic and membranous markers). Selected molecular markers are now being used to distinguish benign from malignant mesothelial proliferations. These guidelines are meant to be a practical diagnostic reference for the pathologist; however, some new pathologic predictors of prognosis and response to therapy are also included.(Arch Pathol Lab Med. 2018;142:89-108; doi: 10.5858/arpa.2017-0124-RA), The pathologic diagnosis of malignant mesothelioma (MM) continues to evolve and be refined as more antibodies and molecular tests become available for general use. This is especially applicable to distinguishing [...]

Published
2018
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20. Supplementary Figure Legends from Pilot and Feasibility Trial Evaluating Immuno-Gene Therapy of Malignant Mesothelioma Using Intrapleural Delivery of Adenovirus-IFNα Combined with Chemotherapy

Author

Sterman, Daniel H., primary, Alley, Evan, primary, Stevenson, James P., primary, Friedberg, Joseph, primary, Metzger, Susan, primary, Recio, Adri, primary, Moon, Edmund K., primary, Haas, Andrew R., primary, Vachani, Anil, primary, Katz, Sharyn I., primary, Sun, Jing, primary, Heitjan, Daniel F., primary, Hwang, Wei-Ting, primary, Litzky, Leslie, primary, Yearley, Jennifer H., primary, Tan, Kay See, primary, Papasavvas, Emmanouil, primary, Kennedy, Paul, primary, Montaner, Luis J., primary, Cengel, Keith A., primary, Simone, Charles B., primary, Culligan, Melissa, primary, Langer, Corey J., primary, and Albelda, Steven M., primary

Published
2023
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21. Supplementary Methods from Pilot and Feasibility Trial Evaluating Immuno-Gene Therapy of Malignant Mesothelioma Using Intrapleural Delivery of Adenovirus-IFNα Combined with Chemotherapy

Author

Sterman, Daniel H., primary, Alley, Evan, primary, Stevenson, James P., primary, Friedberg, Joseph, primary, Metzger, Susan, primary, Recio, Adri, primary, Moon, Edmund K., primary, Haas, Andrew R., primary, Vachani, Anil, primary, Katz, Sharyn I., primary, Sun, Jing, primary, Heitjan, Daniel F., primary, Hwang, Wei-Ting, primary, Litzky, Leslie, primary, Yearley, Jennifer H., primary, Tan, Kay See, primary, Papasavvas, Emmanouil, primary, Kennedy, Paul, primary, Montaner, Luis J., primary, Cengel, Keith A., primary, Simone, Charles B., primary, Culligan, Melissa, primary, Langer, Corey J., primary, and Albelda, Steven M., primary

Published
2023
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22. Supplemental Tables from Pilot and Feasibility Trial Evaluating Immuno-Gene Therapy of Malignant Mesothelioma Using Intrapleural Delivery of Adenovirus-IFNα Combined with Chemotherapy

Author

Sterman, Daniel H., primary, Alley, Evan, primary, Stevenson, James P., primary, Friedberg, Joseph, primary, Metzger, Susan, primary, Recio, Adri, primary, Moon, Edmund K., primary, Haas, Andrew R., primary, Vachani, Anil, primary, Katz, Sharyn I., primary, Sun, Jing, primary, Heitjan, Daniel F., primary, Hwang, Wei-Ting, primary, Litzky, Leslie, primary, Yearley, Jennifer H., primary, Tan, Kay See, primary, Papasavvas, Emmanouil, primary, Kennedy, Paul, primary, Montaner, Luis J., primary, Cengel, Keith A., primary, Simone, Charles B., primary, Culligan, Melissa, primary, Langer, Corey J., primary, and Albelda, Steven M., primary

Published
2023
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23. Supplementary Figure S1 from A 10-Gene Classifier for Distinguishing Head and Neck Squamous Cell Carcinoma and Lung Squamous Cell Carcinoma

Author

Vachani, Anil, primary, Nebozhyn, Michael, primary, Singhal, Sunil, primary, Alila, Linda, primary, Wakeam, Elliot, primary, Muschel, Ruth, primary, Powell, Charles A., primary, Gaffney, Patrick, primary, Singh, Bhuvanesh, primary, Brose, Marcia S., primary, Litzky, Leslie A., primary, Kucharczuk, John, primary, Kaiser, Larry R., primary, Marron, J. Stephen, primary, Showe, Michael K., primary, Albelda, Steven M., primary, and Showe, Louise C., primary

Published
2023
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24. Supplementary Figures from Pilot and Feasibility Trial Evaluating Immuno-Gene Therapy of Malignant Mesothelioma Using Intrapleural Delivery of Adenovirus-IFNα Combined with Chemotherapy

Author

Sterman, Daniel H., primary, Alley, Evan, primary, Stevenson, James P., primary, Friedberg, Joseph, primary, Metzger, Susan, primary, Recio, Adri, primary, Moon, Edmund K., primary, Haas, Andrew R., primary, Vachani, Anil, primary, Katz, Sharyn I., primary, Sun, Jing, primary, Heitjan, Daniel F., primary, Hwang, Wei-Ting, primary, Litzky, Leslie, primary, Yearley, Jennifer H., primary, Tan, Kay See, primary, Papasavvas, Emmanouil, primary, Kennedy, Paul, primary, Montaner, Luis J., primary, Cengel, Keith A., primary, Simone, Charles B., primary, Culligan, Melissa, primary, Langer, Corey J., primary, and Albelda, Steven M., primary

Published
2023
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25. Clinical Outcomes Associated With Pembrolizumab Monotherapy Among Adults With Diffuse Malignant Peritoneal Mesothelioma

Author

Marmarelis, Melina E., primary, Wang, Xiao, additional, Roshkovan, Leonid, additional, Grady, Connor B., additional, Miura, John T., additional, Ginsberg, Michelle S., additional, Ciunci, Christine A., additional, Egger, Jacklynn, additional, Walker, Suzanne, additional, Cercek, Andrea, additional, Foote, Michael B., additional, Litzky, Leslie A., additional, Nash, Garrett, additional, Haas, Andrew R., additional, Karakousis, Giorgos C., additional, Cengel, Keith A., additional, Katz, Sharyn I., additional, Zauderer, Marjorie G., additional, Langer, Corey J., additional, and Offin, Michael, additional

Published
2023
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26. Contributors

Author

Attanoos, Richard L., primary, Aubry, Marie Christine, additional, Barrios, Roberto J., additional, Beasley, Mary Beth, additional, Brainard, Jennifer, additional, Brambilla, Elisabeth, additional, Butnor, Kelly J., additional, Chirieac, Lucian R., additional, Cool, Carlyne D., additional, Deutsch, Gail, additional, Dishop, Megan K., additional, Farver, Carol F., additional, Flieder, Douglas B., additional, Funkhouser, William K., additional, Gal, Anthony A., additional, Gibbs, Allen R., additional, Green, Linda K., additional, Gruber-Mösenbacher, Ulrike, additional, Guinee, Donald G., additional, Haque, Abida K., additional, Homer, Robert, additional, Husain, Aliya N., additional, Ionescu, Diana N., additional, Ivanovic, Marina, additional, Jagirdar, Jaishree, additional, Keating, M. Kelly, additional, Kerr, Keith M., additional, Kraynie, Alyssa, additional, Lantuejoul, Sylvie, additional, Leslie, Kevin O., additional, Litzky, Leslie A., additional, Mani, Haresh, additional, Moreira, Andre L., additional, Murer, Bruno, additional, Neafie, Ronald C., additional, Popper, Helmut H., additional, Procop, Gary W., additional, Rassaei, Negar, additional, Smith, Maxwell L., additional, Sporn, Thomas A., additional, Travis, William D., additional, Walker, David H., additional, White, Frances V., additional, Wright, Joanne L., additional, Zaki, Sherif R., additional, and Zander, Dani S., additional

Published
2018
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29. Clinical activity of pembrolizumab monotherapy in diffuse malignant peritoneal mesothelioma.

Author

Wang, Xiao, primary, Offin, Michael, additional, Roshkovan, Leonid, additional, Miura, John, additional, Ginsberg, Michelle S., additional, Ciunci, Christine Agnes, additional, Egger, Jacklynn V., additional, Walker, Suzanne, additional, Cercek, Andrea, additional, Litzky, Leslie, additional, Nash, Garrett Michael, additional, Haas, Andrew, additional, Karakousis, Giorgos, additional, Cengel, Keith A., additional, Katz, Sharyn I., additional, Zauderer, Marjorie Glass, additional, Langer, Corey J., additional, and Marmarelis, Melina Elpi, additional

Published
2022
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30. Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma

Author

Linette, Gerald P., Stadtmauer, Edward A., Maus, Marcela V., Rapoport, Aaron P., Levine, Bruce L., Emery, Lyndsey, Litzky, Leslie, Bagg, Adam, Carreno, Beatriz M., Cimino, Patrick J., Binder-Scholl, Gwendolyn K., Smethurst, Dominic P., Gerry, Andrew B., Pumphrey, Nick J., Bennett, Alan D., Brewer, Joanna E., Dukes, Joseph, Harper, Jane, Tayton-Martin, Helen K., Jakobsen, Bent K., Hassan, Namir J., Kalos, Michael, and June, Carl H.

Published
2013
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31. Additional file 1 of Pulmonary vascular inflammation with fatal coronavirus disease 2019 (COVID-19): possible role for the NLRP3 inflammasome

Author

Paul, Oindrila, Tao, Jian Qin, West, Eric, Litzky, Leslie, Feldman, Michael, Montone, Kathleen, Rajapakse, Chamith, Bermudez, Christian, and Chatterjee, Shampa

Subjects
sense organs, eye diseases
Abstract

Additional file1: Figure S1. To control for signal arising from IgG immunoreactivity, IgG isotype controls were used: A. Rat IgG isotype controls, B. Nuclear stain DAPI to show cells in the same section, C. Goat IgG isotype controls and D. DAPI.

Published
2022
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33. Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer

Author

Eruslanov, Evgeniy B., Bhojnagarwala, Pratik S., Quatromoni, Jon G., Stephen, Tom Li, Ranganathan, Anjana, Deshpande, Charuhas, Akimova, Tatiana, Vachani, Anil, Litzky, Leslie, Hancock, Wayne W., Conejo-Garcia, Jose R., Feldman, Michael, Albelda, Steven M., and Singhal, Sunil

Subjects
T cells -- Comparative analysis -- Physiological aspects -- Research, Neutrophils -- Physiological aspects -- Research, Lung cancer -- Development and progression -- Comparative analysis -- Research, Health care industry
Abstract

Infiltrating inflammatory cells are highly prevalent within the tumor microenvironment and mediate many processes associated with tumor progression; however, the contribution of specific populations remains unclear. For example, the nature and function of tumor-associated neutrophils (TANs) in the cancer microenvironment is largely unknown. The goal of this study was to provide a phenotypic and functional characterization of TANs in surgically resected lung cancer patients. We found that TANs constituted 5%-25% of cells isolated from the digested human lung tumors. Compared with blood neutrophils, TANs displayed an activated phenotype ([CD62L.sup.lo][CD54.sup.hi]) with a distinct repertoire of chemokine receptors that included CCR5, CCR7, CXCR3, and CXCR4. TANs produced substantial quantities of the proinflammatory factors MCP-1, IL-8, MIP-1α, and IL-6, as well as the antiinflammatory IL-1R antagonist. Functionally, both TANs and neutrophils isolated from distant nonmalignant lung tissue were able to stimulate T cell proliferation and IFN-γ release. Cross-talk between TANs and activated T cells led to substantial upregulation of CD54, CD86, OX40L, and 4-1BBL costimulatory molecules on the neutrophil surface, which bolstered T cell proliferation in a positive-feedback loop. Together our results demonstrate that in the earliest stages of lung cancer, TANs are not immunosuppressive, but rather stimulate T cell responses., Introduction Murine and human studies suggest that tumor initiation and progression are commonly accompanied by 'smoldering' inflammation (1). Tumor-infiltrating myeloid cells represent a significant proportion of the inflammatory cell population [...]

Published
2014
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34. Subcellular Detection of SARS-CoV-2 RNA in Human Tissue Reveals Distinct Localization in Alveolar Type 2 Pneumocytes and Alveolar Macrophages

Author

Acheampong, Kofi K., primary, Schaff, Dylan L., additional, Emert, Benjamin L., additional, Lake, Jonathan, additional, Reffsin, Sam, additional, Shea, Emily K., additional, Comar, Courtney E., additional, Litzky, Leslie A., additional, Khurram, Nigar A., additional, Linn, Rebecca L., additional, Feldman, Michael, additional, Weiss, Susan R., additional, Montone, Kathleen T., additional, Cherry, Sara, additional, and Shaffer, Sydney M., additional

Published
2022
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35. Contributing Authors

Author

Larsen, Brandon T., primary, Revelo, Monica P., additional, Irvine, Rebecca A., additional, Batsides, George P., additional, Chiafarano, Jeanine, additional, Minerowicz, Christine, additional, Litzky, Leslie A., additional, Sanchez, Harold, additional, Rhodes, Roy H., additional, Paueksakon, Paisit, additional, Reddy, Hasini, additional, Hudacko, Rachel, additional, Lento, Patrick, additional, Fligner, Corinne L., additional, Nair, Vidhya, additional, and Hammond, Elizabeth H., additional

Published
2016
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41. Multiplexed detection of SARS-CoV-2 genomic and subgenomic RNA using in situ hybridization

Author

Acheampong, Kofi K., primary, Schaff, Dylan L., additional, Emert, Benjamin L., additional, Lake, Jonathan, additional, Reffsin, Sam, additional, Shea, Emily K., additional, Comar, Courtney E., additional, Litzky, Leslie A., additional, Khurram, Nigar A., additional, Linn, Rebecca L., additional, Feldman, Michael, additional, Weiss, Susan R., additional, Montone, Kathleen T., additional, Cherry, Sara, additional, and Shaffer, Sydney M., additional

Published
2021
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44. Alpha‐defensins: risk factor for thrombosis in COVID‐19 infection

Author

Abdeen, Suhair, primary, Bdeir, Khalil, additional, Abu‐Fanne, Rami, additional, Maraga, Emad, additional, Higazi, Mohamed, additional, Khurram, Nigar, additional, Feldman, Michael, additional, Deshpande, Charuhas, additional, Litzky, Leslie A., additional, Heyman, Samuel N., additional, Montone, Kathleen T., additional, Cines, Douglas B., additional, and Higazi, Abd Al‐Roof, additional

Published
2021
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45. Comparison of Nuclear Grade, Necrosis, and Histologic Subtype Between Biopsy and Resection in Pleural Malignant Mesothelioma: An International Multi-Institutional Analysis

Author

Schulte, Jefree J, primary, Chapel, David B, additional, Attanoos, Richard, additional, Brcic, Luka, additional, Burn, Juliet, additional, Butnor, Kelly J, additional, Chang, Nina, additional, Chen, Heather, additional, Dacic, Sanja, additional, De Perrot, Marc, additional, Fukuoka, Junya, additional, Galateau-Salle, Francoise, additional, Godschachner, Theresa, additional, Hiroshima, Kenzo, additional, Klebe, Sonja, additional, Krausz, Thomas, additional, Litzky, Leslie, additional, Marchevsky, Alberto M, additional, Mueller, Jeffrey, additional, Nabeshima, Kazuki, additional, Nicholson, Andrew G, additional, Pal, Prodipto, additional, Roden, Anja C, additional, Rorvig, Sara, additional, Santoni-Rugiu, Eric, additional, Tazelaar, Henry, additional, Tsao, Ming-Sound, additional, Walts, Ann E, additional, Weynand, Birgit, additional, Zaizen, Yoshiaki, additional, Zhang, Yu Zhi, additional, and Husain, Aliya N, additional

Published
2021
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46. Defining the spatial landscape of KRASmutated congenital pulmonary airway malformations: a distinct entity with a spectrum of histopathologic features

Author

Nelson, Nya D., Xu, Feng, Chandrasekaran, Prashant, Litzky, Leslie A., Peranteau, William H., Frank, David B., Li, Marilyn, and Pogoriler, Jennifer

Abstract

The potential pathogenetic mechanisms underlying the varied morphology of congenital pulmonary airway malformations (CPAMs) have not been molecularly determined, but a subset have been shown to contain clusters of mucinous cells (MCC). These clusters are believed to serve as precursors for potential invasive mucinous adenocarcinoma, and they are associated with KRAScodon 12 mutations. To assess the universality of KRASmutations in MCCs, we sequenced exon 2 of KRASin 61 MCCs from 18 patients, and we found a KRAScodon 12 mutation in all 61 MCCs. Furthermore, all MCCs from a single patient always had the same KRASmutation, and the same KRASmutation was also found in non-mucinous lesional tissue. Next generation sequencing of seven MCCs showed no other mutations or copy number variations. Sequencing of 46 additional CPAMs with MCCs revealed KRASmutations in non-mucinous lesional tissue in all cases. RNA in situ hybridization confirmed widespread distribution of cells with mutant KRASRNA, even extending outside of the bronchiolar type epithelium. We identified 25 additional CPAMs with overall histologic architecture similar to CPAMs with KRASmutations but without identifiable MCCs, and we found KRASmutations in 17 (68%). The histologic features of these KRASmutated CPAMs included type 1 and type 3 morphology, as well as lesions with an intermediate histologic appearance, and analysis revealed a strong correlation between the specific amino acid substitution and histomorphology. These findings, together with previously published model organism data, suggests that the formation of type 1 and 3 CPAMs is driven by mosaic KRASmutations arising in the lung epithelium early in development and places them within the growing field of mosaic RASopathies. The presence of widespread epithelial mutation explains late metastatic disease in incompletely resected patients and reinforces the recommendation for complete resection of these lesions.

Published
2022
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