Search

Your search keyword '"Lipton, S."' showing total 678 results
Start Over Author "Lipton, S."
678 results on '"Lipton, S."'

1. Predictors of attrition in a cohort study of HIV infection and methamphetamine dependence

Author

Cattie, J, Marquine, MJ, Bolden, KA, Obermeit, LC, Morgan, EE, Franklin, DR, Umlauf, A, Beck, JM, Hampton Atkinson, J, Woods, SP, Grant, I, Ellis, RJ, Achim, C, Letendre, S, Schrier, R, Heaton, RK, Atkinson, JH, Cherner, M, Marcotte, T, Brown, G, Jernigan, T, Dale, A, Liu, T, Scadeng, M, Fennema-Notestine, C, Archibald, SL, Masliah, E, Lipton, S, Marquie, J, Gamst, AC, Cushman, C, Abramson, I, Vaida, F, Deutsch, R, Minassian, A, Perry, W, Geyer, M, Henry, B, Grethe, AB, Paulus, M, Morris, S, Smith, DM, Semenova, S, Markou, A, and Kaul, M

Subjects
Nursing, Public Health and Health Services, Psychology, Substance Abuse
Abstract

Longitudinal cohort studies of HIV and substance use disorders play an important role in understanding these conditions, but high rates of attrition can threaten their integrity and generalizability. This study aimed to identify factors associated with attrition in a 5-year observational cohort study of 469 individuals with and without HIV infection and methamphetamine (MA) dependence. Rates of attrition in our four study groups were approximately 24% in HIV-MA-, 15% in HIV+MA-, 56% in HIV-MA+, and 47% in HIV+MA+ individuals. Predictors of attrition in the overall cohort included history of MA, alcohol, and other substance dependence, learning impairment, reduced cognitive reserve, and independence in activities of daily living (all ps < 0.05), but varied somewhat by clinical group. Of particular note, enrollment in a neuroimaging sub-study was associated with significantly boosted rates of retention in the MA groups. Results from this investigation highlight the complexity of the clinical factors that influence retention in cohort studies of HIV-infected MA users and might guide the development and implementation of targeted retention efforts.

Published
2015

2. Shallow Encoding and Forgetting Are Associated with Dependence in Instrumental Activities of Daily Living Among Older Adults Living with HIV Infection

Author

Fazeli, PL, Doyle, KL, Scott, JC, Iudicello, JE, Casaletto, KB, Weber, E, Moore, DJ, Morgan, EE, Grant, I, Woods, SP, Hampton Atkinson, J, Ellis, RJ, Allen McCutchan, J, Marcotte, TD, Marquie-Beck, J, Sherman, M, Letendre, S, Capparelli, E, Schrier, R, Rosario, D, LeBlanc, S, Heaton, RK, Cherner, M, Dawson, M, Jernigan, T, Fennema-Notestine, C, Archibald, SL, Hesselink, J, Annese, J, Taylor, MJ, Masliah, E, Achim, C, Everall, I, Richman, D, Smith, DM, Lipton, S, Gamst, AC, Cushman, C, Abramson, I, Vaida, F, Deutsch, R, and Umlauf, A

Subjects
Psychology, Clinical and Health Psychology, Applied and Developmental Psychology, Rehabilitation, HIV/AIDS, Neurodegenerative, Behavioral and Social Science, Acquired Cognitive Impairment, Brain Disorders, Clinical Research, Infectious Diseases, Sexually Transmitted Infections, Neurosciences, Aging, Infection, Activities of Daily Living, Adult, Aged, Cohort Studies, Disabled Persons, Female, HIV Infections, Humans, Male, Memory Disorders, Middle Aged, Neuropsychological Tests, Surveys and Questionnaires, Verbal Learning, Disability, Everyday functioning, Learning and memory, HIV Neurobehavioral Research Program (HNRP) Group, Cognitive Sciences, Clinical Psychology, Applied and developmental psychology, Biological psychology, Clinical and health psychology
Abstract

Aging and HIV are both risk factors for memory deficits and declines in real-world functioning. However, we know little about the profile of memory deficits driving instrumental activities of daily living (IADL) declines across the lifespan in HIV. This study examined 145 younger (

Published
2014

26. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Author

Galluzzi, Lorenzo, Vitale, Ilio, Aaronson, S. A., Abrams, J. M., Adam, Dieter, Agostinis, Patrizia, Alnemri, E. S., Altucci, Lucia, Amelio, Ivano, Andrews, D. W., Annicchiarico-Petruzzelli, Margherita, Antonov, A. V., Arama, Eli, Baehrecke, E. H., Barlev, N. A., Bazan, N. G., Bernassola, Francesca, Bertrand, M. J. M., Bianchi, Katiuscia, Blagosklonny, M. V., Blomgren, Kla, Borner, Christoph, Boya, Patricia, Brenner, Catherine, Campanella, Michelangelo, Candi, Eleonora, Carmona-Gutierrez, Didac, Cecconi, Francesco, Chan, F. K. -M., Chandel, N. S., Cheng, E. H., Chipuk, J. E., Cidlowski, J. A., Ciechanover, Aaron, Cohen, G. M., Conrad, Marcu, Cubillos-Ruiz, J. R., Czabotar, P. E., D’Angiolella, Vincenzo, Dawson, T. M., Dawson, V. L., de Laurenzi, Vincenzo, De Maria Marchiano, Ruggero, Debatin, Klaus-Michael, Deberardinis, R. J., Deshmukh, Mohanish, Di Daniele, Nicola, Di Virgilio, Francesco, Dixit, V. M., Dixon, S. J., Duckett, C. S., Dynlacht, B. D., El-Deiry, W. S., Elrod, J. W., Fimia, Gian Maria, Fulda, Simone, García-Sáez, A. J., Garg, A. D., Garrido, Carmen, Gavathiotis, Evripidi, Golstein, Pierre, Gottlieb, Eyal, Green, D. R., Greene, L. A., Gronemeyer, Hinrich, Gross, Atan, Hajnoczky, Gyorgy, Hardwick, J. M., Harris, I. S., Hengartner, M. O., Hetz, Claudio, Ichijo, Hidenori, Jäättelä, Marja, Joseph, Bertrand, Jost, P. J., Juin, P. P., Kaiser, W. J., Karin, Michael, Kaufmann, Thoma, Kepp, Oliver, Kimchi, Adi, Kitsis, R. N., Klionsky, D. J., Knight, R. A., Kumar, Sharad, Lee, S. W., Lemasters, J. J., Levine, Beth, Linkermann, Andrea, Lipton, S. A., Lockshin, R. A., López-Otín, Carlo, Lowe, S. W., Luedde, Tom, Lugli, Enrico, Macfarlane, Marion, Madeo, Frank, Malewicz, Michal, Malorni, Walter, Manic, Gwenola, Marine, Jean-Christophe, Martin, S. J., Martinou, Jean-Claude, Medema, Jan Paul, Mehlen, Patrick, Meier, Pascal, Melino, Sonia, Miao, E. A., Molkentin, J. D., Moll, U. M., Muñoz-Pinedo, Cristina, Nagata, Shigekazu, Nuñez, Gabriel, Oberst, Andrew, Oren, Moshe, Overholtzer, Michael, Pagano, Michele, Panaretakis, Theochari, Pasparakis, Manoli, Penninger, J. M., Pereira, D. M., Pervaiz, Shazib, Peter, M. E., Piacentini, Mauro, Pinton, Paolo, Prehn, J. H. M., Puthalakath, Hamsa, Rabinovich, G. A., Rehm, Marku, Rizzuto, Rosario, Rodrigues, C. M. P., Rubinsztein, D. C., Rudel, Thoma, Ryan, K. M., Sayan, Emre, Scorrano, Luca, Shao, Feng, Shi, Yufang, Silke, John, Simon, Hans-Uwe, Sistigu, Antonella, Stockwell, B. R., Strasser, Andrea, Szabadkai, Gyorgy, Tait, S. W. G., Tang, Daolin, Tavernarakis, Nektario, Thorburn, Andrew, Tsujimoto, Yoshihide, Turk, Bori, Vanden Berghe, Tom, Vandenabeele, Peter, Vander Heiden, M. G., Villunger, Andrea, Virgin, H. W., Vousden, K. H., Vucic, Domagoj, Wagner, E. F., Walczak, Henning, Wallach, David, Wang, Ying, Wells, J. A., Wood, Will, Yuan, Junying, Zakeri, Zahra, Zhivotovsky, Bori, Zitvogel, Laurence, Melino, Gerry, Kroemer, Guido, De Maria Marchiano, Ruggero (ORCID:0000-0003-2255-0583), Sistigu, Antonella (ORCID:0000-0002-2528-1238), Galluzzi, Lorenzo, Vitale, Ilio, Aaronson, S. A., Abrams, J. M., Adam, Dieter, Agostinis, Patrizia, Alnemri, E. S., Altucci, Lucia, Amelio, Ivano, Andrews, D. W., Annicchiarico-Petruzzelli, Margherita, Antonov, A. V., Arama, Eli, Baehrecke, E. H., Barlev, N. A., Bazan, N. G., Bernassola, Francesca, Bertrand, M. J. M., Bianchi, Katiuscia, Blagosklonny, M. V., Blomgren, Kla, Borner, Christoph, Boya, Patricia, Brenner, Catherine, Campanella, Michelangelo, Candi, Eleonora, Carmona-Gutierrez, Didac, Cecconi, Francesco, Chan, F. K. -M., Chandel, N. S., Cheng, E. H., Chipuk, J. E., Cidlowski, J. A., Ciechanover, Aaron, Cohen, G. M., Conrad, Marcu, Cubillos-Ruiz, J. R., Czabotar, P. E., D’Angiolella, Vincenzo, Dawson, T. M., Dawson, V. L., de Laurenzi, Vincenzo, De Maria Marchiano, Ruggero, Debatin, Klaus-Michael, Deberardinis, R. J., Deshmukh, Mohanish, Di Daniele, Nicola, Di Virgilio, Francesco, Dixit, V. M., Dixon, S. J., Duckett, C. S., Dynlacht, B. D., El-Deiry, W. S., Elrod, J. W., Fimia, Gian Maria, Fulda, Simone, García-Sáez, A. J., Garg, A. D., Garrido, Carmen, Gavathiotis, Evripidi, Golstein, Pierre, Gottlieb, Eyal, Green, D. R., Greene, L. A., Gronemeyer, Hinrich, Gross, Atan, Hajnoczky, Gyorgy, Hardwick, J. M., Harris, I. S., Hengartner, M. O., Hetz, Claudio, Ichijo, Hidenori, Jäättelä, Marja, Joseph, Bertrand, Jost, P. J., Juin, P. P., Kaiser, W. J., Karin, Michael, Kaufmann, Thoma, Kepp, Oliver, Kimchi, Adi, Kitsis, R. N., Klionsky, D. J., Knight, R. A., Kumar, Sharad, Lee, S. W., Lemasters, J. J., Levine, Beth, Linkermann, Andrea, Lipton, S. A., Lockshin, R. A., López-Otín, Carlo, Lowe, S. W., Luedde, Tom, Lugli, Enrico, Macfarlane, Marion, Madeo, Frank, Malewicz, Michal, Malorni, Walter, Manic, Gwenola, Marine, Jean-Christophe, Martin, S. J., Martinou, Jean-Claude, Medema, Jan Paul, Mehlen, Patrick, Meier, Pascal, Melino, Sonia, Miao, E. A., Molkentin, J. D., Moll, U. M., Muñoz-Pinedo, Cristina, Nagata, Shigekazu, Nuñez, Gabriel, Oberst, Andrew, Oren, Moshe, Overholtzer, Michael, Pagano, Michele, Panaretakis, Theochari, Pasparakis, Manoli, Penninger, J. M., Pereira, D. M., Pervaiz, Shazib, Peter, M. E., Piacentini, Mauro, Pinton, Paolo, Prehn, J. H. M., Puthalakath, Hamsa, Rabinovich, G. A., Rehm, Marku, Rizzuto, Rosario, Rodrigues, C. M. P., Rubinsztein, D. C., Rudel, Thoma, Ryan, K. M., Sayan, Emre, Scorrano, Luca, Shao, Feng, Shi, Yufang, Silke, John, Simon, Hans-Uwe, Sistigu, Antonella, Stockwell, B. R., Strasser, Andrea, Szabadkai, Gyorgy, Tait, S. W. G., Tang, Daolin, Tavernarakis, Nektario, Thorburn, Andrew, Tsujimoto, Yoshihide, Turk, Bori, Vanden Berghe, Tom, Vandenabeele, Peter, Vander Heiden, M. G., Villunger, Andrea, Virgin, H. W., Vousden, K. H., Vucic, Domagoj, Wagner, E. F., Walczak, Henning, Wallach, David, Wang, Ying, Wells, J. A., Wood, Will, Yuan, Junying, Zakeri, Zahra, Zhivotovsky, Bori, Zitvogel, Laurence, Melino, Gerry, Kroemer, Guido, De Maria Marchiano, Ruggero (ORCID:0000-0003-2255-0583), and Sistigu, Antonella (ORCID:0000-0002-2528-1238)

Abstract

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field.

Published
2018

36. Erythropoietin: not just about erythropoiesis

Author

Ghezzi, P., Bernaudin, M., Bernaudinb, M., Bianchi, R., Bianchic, R., Blomgren, K., Brines, M., Campana, W., Cavaletti, G., Cerami, A., Chopp, M., Coleman, T., Digicaylioglu, M., Ehrenreich, H., Erbayraktar, S., Erbayraktar, Z., Gassmann, M., Genc, S., Gokmen, N., Grasso, G., Juul, S., Lipton, S. A., Hand, C. C., Latini, R., Lauria, G., Leist, M., Newton, S. S., Petit, E., Probert, L., Sfacteria, Alessandra, Siren, A., Talan, M., Thiemermann, C., Westenbrink, D., Yaqoob, M., Zhu, C., University of Zurich, Ghezzi, P, Bernaudinb, M, Bianchic, R, Blomgren, K, Brines, M, Campana, W, Cavaletti, G, Cerami, A, Chopp, M, Coleman, T, Digicaylioglu, M, Ehrenreich, H, Erbayraktar, S, Erbayraktar, Z, Gassmann, M, Genc, S, Gokmen, N, Grasso, G, Juul, S, Lipton, S, Hand, C, Latini, R, Lauria, G, Leist, M, Newton, S, Petit, E, Probert, L, Sfacteria, A, Siren, A, Talan, M, Thiemermann, C, Westenbrink, D, Yaqoob, M, and Zhu, C

Subjects
erythropoyetin, Receptors, Cell Surface, 2700 General Medicine, Bioinformatics, Erythropoiesis, Erythropoietin, Humans, Neoplasms, Neuroprotective Agents, Receptors, Cell Surface, Article, 03 medical and health sciences, 0302 clinical medicine, Receptors, Erythropoietin, medicine, Brain function, 030304 developmental biology, 0303 health sciences, business.industry, General Medicine, 10081 Institute of Veterinary Physiology, 3. Good health, Original data, Erythropoietin receptor, Clinical trial, Action (philosophy), Immunology, 570 Life sciences, biology, business, 030217 neurology & neurosurgery, medicine.drug
Abstract

A paper by Sinclair and colleagues1 in Blood challenges, on the basis of observations on cell lines, the concept that erythropoietin has activities unrelated to erythrodifferentiation. Sinclair and colleagues, based at Amgen, have published six papers since 2006 focused on whether the erythropoietin receptor (EPOR) is expressed by tumour cells—a fact that, if true, could have adverse effects for the use of erythropoietin in cancer. They conclude that EPOR is not expressed by many of the cells previously reported to express EPOR and exhibit cytoprotection by erythropoietin, and question the entire concept that erythropoietin is active on non-haemopoietic cells. Although sometimes data from one laboratory are not replicated in another, many investigators have reported trophic or antiapoptotic effects of erythropoietin on many cells, including those that Sinclair and colleagues report in tabular form without presenting their original data. In fact, over the past 10 years, multiple investigators have shown that erythropoietin is tissue-protective, anti-inflammatory, and promotes neurogenesis and angiogenesis. The observation that erythropoietin is neuroprotective in vivo2 ignited substantial interest in its roles and possible therapeutic use in various diseases. Searching for “erythropoietin AND protect*”, PubMed gives 863 hits of which we identified 346 research papers reporting a protective or reparative action, and only ten a lack of extra-haemopoietic effects. Having no data to compare with previous studies, it is difficult to understand whether “inconsistent, irreproducible and at best modest (10–20%) effects”1 refers to the inconsistency of the effect or to Sinclair and colleagues' experimental technique. Sinclair and colleagues expand their conclusions further by stating that in vivo studies of erythropoietin in animal models of damage are faulty and that they “do not believe [that] clinical studies examining an alleged ‘direct’ effect of ESAs [erythropoiesis-stimulating agents] on heart or brain function or repair are well founded”.1 The term “alleged” is a hyperbole when referring to the tissue-protective actions of erythropoietin that, independently of the receptors implicated, are supported by hundreds of studies, two meta-analyses,3,4 and some clinical trials, although we agree that caution should be used because of potential side-effects.5 Cratylus, discussing with Plato, stated that names express the essence of the thing. This is hardly the case for cytokines: look at tumour necrosis factor or inter leukin 1. Although, from a pharmaceutical perspective, it would be convenient if erythropoietin had no activities outside erythropoiesis, this is wishful thinking. The field would be better served by efforts to understand the full spectrum of erythropoietin's actions.

Published
2010

37. Portable lactate analyzer for measuring lactate in cerebrospinal fluid (CSF) and plasma - Method-comparison evaluations

Author

de Almeida, SM, Marquie-Beck, J, Bhatt, A, Letendre, S, McCutchan, JA, Ellis, RJ, Heaton, RK, Grant, I, Atkinson, JH, Marcotte, TD, Sherman, M, Best, B, Schrier, R, Alexander, T, Rosario, D, Woods, SP, Cherner, M, Moore, DJ, Dawson, M, Fennema-Notestine, C, Jernigan, T, Buchsbaum, MS, Hesselink, J, Archibald, SL, Brown, G, Buxton, R, Dale, A, Liu, T, Masliah, E, Achim, C, Everall, I, Smith, DM, Richman, D, Lipton, S, Gamst, AC, Cushman, C, Abramson, I, Vaida, F, Deutsch, R, Umlauf, A, and Kao, C

Abstract

Increased plasma lactate levels can indicate the presence of metabolic disorders in HIV infected individuals. Objective: To determine whether a portable analyzer is valid for measuring cerebrospinal fluid (CSF) and plasma lactate levels in HIV infected individuals. Method: CSF and plasma were collected from 178 subjects. Samples tested by the Accutrend® portable analyzer were compared to those tested by a reference device (SYNCHRON LX® 20). Results: The portable analyzer had in plasma sensitivity of 0.95 and specificity 0.87. For CSF the specificity was 0.95; the sensitivity 0.33; the negative predictive value was 95% and the positive predictive value 33%. Conclusions: These findings support the validity of the portable analyzer in measuring lactate concentrations in CSF that fall within the normal range. The relatively poor positive predictive value indicates that a result above the reference range may represent a "false positive test", and should be confirmed by the reference device before concluding abnormality.

Published
2014

39. Essential versus accessory aspects of cell death: Recommendations of the NCCD 2015

Author

Galluzzi, L., Bravo-San Pedro, J. M., Vitale, Ilio, Aaronson, S. A., Abrams, J. M., Adam, D., Alnemri, E. S., Altucci, L., Andrews, D., Annicchiarico-Petruzzelli, M., Baehrecke, E. H., Bazan, N. G., Bertrand, M. J., Bianchi, K., Blagosklonny, M. V., Blomgren, K., Borner, C., Bredesen, D. E., Brenner, C., Campanella, M., Candi, E., Cecconi, F., Chan, F. K., Chandel, N. S., Cheng, E. H., Chipuk, J. E., Cidlowski, J. A., Ciechanover, A., Dawson, T. M., Dawson, V. L., De Laurenzi, V., De Maria Marchiano, Ruggero, Debatin, K. -M., Di Daniele, N., Dixit, V. M., Dynlacht, B. D., El-Deiry, W. S., Fimia, G. M., Flavell, R. A., Fulda, S., Garrido, C., Gougeon, M. -L., Green, D. R., Gronemeyer, H., Hajnoczky, G., Hardwick, J. M., Hengartner, M. O., Ichijo, H., Joseph, B., Jost, P. J., Kaufmann, T., Kepp, O., Klionsky, D. J., Knight, R. A., Kumar, S., Lemasters, J. J., Levine, B., Linkermann, A., Lipton, S. A., Lockshin, R. A., López-Otín, C., Lugli, E., Madeo, F., Malorni, W., Marine, J. -C., Martin, S. J., Martinou, J. -C., Medema, Jan Paul, Meier, P., Melino, S., Mizushima, N., Moll, U., Muñoz-Pinedo, C., Nuñez, G., Oberst, A., Panaretakis, T., Penninger, J. M., Peter, M. E., Piacentini, M., Calzavara Pinton, Piergiacomo, Prehn, J. H., Puthalakath, H., Rabinovich, G. A., Ravichandran, K. S., Rizzuto, R., Rodrigues, C. M., Rubinsztein, D. C., Rudel, T., Shi, Y., Simon, H. -U., Stockwell, B. R., Szabadkai, G., Tait, S. W., Tang, H. L., Tavernarakis, N., Tsujimoto, Y., Vanden Berghe, T., Vandenabeele, P., Villunger, A., Wagner, E. F., Walczak, H., White, E., Wood, W. G., Yuan, J., Zakeri, Z., Zhivotovsky, B., Melino, G., Kroemer, G., Vitale, I., De Maria Marchiano, R. (ORCID:0000-0003-2255-0583), Medema, J. P., Calzavara Pinton, P., Galluzzi, L., Bravo-San Pedro, J. M., Vitale, Ilio, Aaronson, S. A., Abrams, J. M., Adam, D., Alnemri, E. S., Altucci, L., Andrews, D., Annicchiarico-Petruzzelli, M., Baehrecke, E. H., Bazan, N. G., Bertrand, M. J., Bianchi, K., Blagosklonny, M. V., Blomgren, K., Borner, C., Bredesen, D. E., Brenner, C., Campanella, M., Candi, E., Cecconi, F., Chan, F. K., Chandel, N. S., Cheng, E. H., Chipuk, J. E., Cidlowski, J. A., Ciechanover, A., Dawson, T. M., Dawson, V. L., De Laurenzi, V., De Maria Marchiano, Ruggero, Debatin, K. -M., Di Daniele, N., Dixit, V. M., Dynlacht, B. D., El-Deiry, W. S., Fimia, G. M., Flavell, R. A., Fulda, S., Garrido, C., Gougeon, M. -L., Green, D. R., Gronemeyer, H., Hajnoczky, G., Hardwick, J. M., Hengartner, M. O., Ichijo, H., Joseph, B., Jost, P. J., Kaufmann, T., Kepp, O., Klionsky, D. J., Knight, R. A., Kumar, S., Lemasters, J. J., Levine, B., Linkermann, A., Lipton, S. A., Lockshin, R. A., López-Otín, C., Lugli, E., Madeo, F., Malorni, W., Marine, J. -C., Martin, S. J., Martinou, J. -C., Medema, Jan Paul, Meier, P., Melino, S., Mizushima, N., Moll, U., Muñoz-Pinedo, C., Nuñez, G., Oberst, A., Panaretakis, T., Penninger, J. M., Peter, M. E., Piacentini, M., Calzavara Pinton, Piergiacomo, Prehn, J. H., Puthalakath, H., Rabinovich, G. A., Ravichandran, K. S., Rizzuto, R., Rodrigues, C. M., Rubinsztein, D. C., Rudel, T., Shi, Y., Simon, H. -U., Stockwell, B. R., Szabadkai, G., Tait, S. W., Tang, H. L., Tavernarakis, N., Tsujimoto, Y., Vanden Berghe, T., Vandenabeele, P., Villunger, A., Wagner, E. F., Walczak, H., White, E., Wood, W. G., Yuan, J., Zakeri, Z., Zhivotovsky, B., Melino, G., Kroemer, G., Vitale, I., De Maria Marchiano, R. (ORCID:0000-0003-2255-0583), Medema, J. P., and Calzavara Pinton, P.

Abstract

Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is generally referred to as 'accidental cell death' (ACD). In most settings, however, cell death is initiated by a genetically encoded apparatus, correlating with the fact that its course can be altered by pharmacologic or genetic interventions. 'Regulated cell death' (RCD) can occur as part of physiologic programs or can be activated once adaptive responses to perturbations of the extracellular or intracellular microenvironment fail. The biochemical phenomena that accompany RCD may be harnessed to classify it into a few subtypes, which often (but not always) exhibit stereotyped morphologic features. Nonetheless, efficiently inhibiting the processes that are commonly thought to cause RCD, such as the activation of executioner caspases in the course of apoptosis, does not exert true cytoprotective effects in the mammalian system, but simply alters the kinetics of cellular demise as it shifts its morphologic and biochemical correlates. Conversely, bona fide cytoprotection can be achieved by inhibiting the transduction of lethal signals in the early phases of the process, when adaptive responses are still operational. Thus, the mechanisms that truly execute RCD may be less understood, less inhibitable and perhaps more homogeneous than previously thought. Here, the Nomenclature Committee on Cell Death formulates a set of recommendations to help scientists and researchers to discriminate between essential and accessory aspects of cell death.

Published
2015

40. Expression of mannose binding lectin in HIV-1-infected brain: Implications for HIV-related neuronal damage and neuroaids

Author

Singh, KK, Nathamu, S, Adame, A, Alire, TU, Dumaop, W, Gouaux, B, Moore, DJ, Masliah, E, Grant, I, Atkinson, JH, Ellis, RJ, McCutchan, JA, Marcotte, TD, Marquie-Beck, J, Sherman, M, Letendre, S, Capparelli, E, Schrier, R, Alexander, T, Rosario, RND, LeBlanc, S, Heaton, RK, Woods, SP, Cherner, M, Dawson, M, Jernigan, T, Fennema-Notestine, C, Archibald, SL, Hesselink, MAJ, Annese, J, Taylor, MJ, Achim, C, Everall, I, Richman, D, Smith, DM, Lipton, S, von Jaeger, R, Gamst, AC, Abramson, I, Vaida, F, Deutsch, R, Umlauf, A, and Wolfson, T

Subjects
chemical and pharmacologic phenomena, bacterial infections and mycoses
Abstract

Mannose binding lectin (MBL) activates complement pathway that leads to pathogen opsonization and phagocytosis. MBL deficiency is linked to HIV transmission and disease progression. We sought to determine the role of MBL in HIV encephalitis (HIVE) by evaluating its presence and distribution in the HIV-1-infected brain and by assessing its association with monocyte chemoattractant protein-1 (MCP-1) expression. This retrospective study utilized archived post-mortem brain tissues obtained from 35 individuals enrolled in a longitudinal study as part of the California NeuroAIDS Tissue Network. MBL, MCP-1 and brain cell markers in post-mortem brain tissues with or without HIVE were evaluated using immunocytochemistry, immunofluorescence, confocal microscopy, and western blots. MBL was expressed in neurons, astrocytes, microglia, and oligodendrocytes of the frontal cortex of the HIV-1-infected brain. Overall, there were 30% to 40% more MBL-positive brain cells in HIVE vs non-HIVE cases (P = 0.01, paired t-test). Specifically, there was an increased MBL expression in the neuronal axons of HIVE cases. Also, western blots showed 3- to 4-fold higher levels of 78 kD MBL trimers in HIVE vs non-HIVE cases. This MBL-HIVE link was further confirmed by MBL associated higher MCP-1 expression in HIVE vs non-HIVE cases. HIV negative healthy individuals and normal or the gp120 transgenic mice did not show any differential MBL expression. Increased MBL expression in the major brain cell types, specifically in the neuronal axons of HIVE brain, and MBL associated higher MCP-1 expression in HIVE suggest that MBL could cause neuroinflammation and neuronal injury through MBL complement activation pathway. © 2011 Singh et al, publisher and licensee Dove Medical Press Ltd.

Published
2011

42. Neuroprotection

Author

Wong, T, Crowston, J, Stalmans, I, Cordeiro, F, Migdal, C, Casson, R, Danesh, H, Gandolfi, S, Kipnis, T, Levin, L, Lipton, S, Martin, K, Osborne, N, Schmetterer, L, Schwartz, M, Trounce, I, Vidal Sanz, M, and Nucci, C

Subjects
Settore MED/30 - Malattie Apparato Visivo
Published
2010

46. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

Author

Galluzzi, L, primary, Bravo-San Pedro, J M, additional, Vitale, I, additional, Aaronson, S A, additional, Abrams, J M, additional, Adam, D, additional, Alnemri, E S, additional, Altucci, L, additional, Andrews, D, additional, Annicchiarico-Petruzzelli, M, additional, Baehrecke, E H, additional, Bazan, N G, additional, Bertrand, M J, additional, Bianchi, K, additional, Blagosklonny, M V, additional, Blomgren, K, additional, Borner, C, additional, Bredesen, D E, additional, Brenner, C, additional, Campanella, M, additional, Candi, E, additional, Cecconi, F, additional, Chan, F K, additional, Chandel, N S, additional, Cheng, E H, additional, Chipuk, J E, additional, Cidlowski, J A, additional, Ciechanover, A, additional, Dawson, T M, additional, Dawson, V L, additional, De Laurenzi, V, additional, De Maria, R, additional, Debatin, K-M, additional, Di Daniele, N, additional, Dixit, V M, additional, Dynlacht, B D, additional, El-Deiry, W S, additional, Fimia, G M, additional, Flavell, R A, additional, Fulda, S, additional, Garrido, C, additional, Gougeon, M-L, additional, Green, D R, additional, Gronemeyer, H, additional, Hajnoczky, G, additional, Hardwick, J M, additional, Hengartner, M O, additional, Ichijo, H, additional, Joseph, B, additional, Jost, P J, additional, Kaufmann, T, additional, Kepp, O, additional, Klionsky, D J, additional, Knight, R A, additional, Kumar, S, additional, Lemasters, J J, additional, Levine, B, additional, Linkermann, A, additional, Lipton, S A, additional, Lockshin, R A, additional, López-Otín, C, additional, Lugli, E, additional, Madeo, F, additional, Malorni, W, additional, Marine, J-C, additional, Martin, S J, additional, Martinou, J-C, additional, Medema, J P, additional, Meier, P, additional, Melino, S, additional, Mizushima, N, additional, Moll, U, additional, Muñoz-Pinedo, C, additional, Nuñez, G, additional, Oberst, A, additional, Panaretakis, T, additional, Penninger, J M, additional, Peter, M E, additional, Piacentini, M, additional, Pinton, P, additional, Prehn, J H, additional, Puthalakath, H, additional, Rabinovich, G A, additional, Ravichandran, K S, additional, Rizzuto, R, additional, Rodrigues, C M, additional, Rubinsztein, D C, additional, Rudel, T, additional, Shi, Y, additional, Simon, H-U, additional, Stockwell, B R, additional, Szabadkai, G, additional, Tait, S W, additional, Tang, H L, additional, Tavernarakis, N, additional, Tsujimoto, Y, additional, Vanden Berghe, T, additional, Vandenabeele, P, additional, Villunger, A, additional, Wagner, E F, additional, Walczak, H, additional, White, E, additional, Wood, W G, additional, Yuan, J, additional, Zakeri, Z, additional, Zhivotovsky, B, additional, Melino, G, additional, and Kroemer, G, additional

Published
2014
Full Text
View/download PDF

48. Isogeometric boundary element analysis using unstructured T-splines

Author

Scott, M. A., Simpson, R. N., Evans, J. A., Lipton, S., Bordas, Stéphane, Hughes, T. J. R., Sederberg, T. W., Scott, M. A., Simpson, R. N., Evans, J. A., Lipton, S., Bordas, Stéphane, Hughes, T. J. R., and Sederberg, T. W.

Abstract

We couple collocated isogeometric boundary element methods and unstructured analysis-suitable T-spline surfaces for linear elastostatic problems. We extend the definition of analysis-suitable T-splines to encompass unstructured control grids (unstructured meshes) and develop basis functions which are smooth (rational) polynomials defined in terms of the Bézier extraction framework and which pass standard patch tests. We then develop a collocation procedure which correctly accounts for sharp edges and corners, extraordinary points, and T-junctions. This approach is applied to several three-dimensional problems, including a real-world T-spline model of a propeller. We believe this work clearly illustrates the power of combining new analysis-suitable computer aided design technologies with established analysis methodologies, in this case, the boundary element method. © 2012 Elsevier B.V.

Published
2013

49. Erythropoietin: not just about erythropoiesis

Author

Ghezzi, P, Bernaudinb, M, Bianchic, R, Blomgren, K, Brines, M, Campana, W, Cavaletti, G, Cerami, A, Chopp, M, Coleman, T, Digicaylioglu, M, Ehrenreich, H, Erbayraktar, S, Erbayraktar, Z, Gassmann, M, Genc, S, Gokmen, N, Grasso, G, Juul, S, Lipton, S, Hand, C, Latini, R, Lauria, G, Leist, M, Newton, S, Petit, E, Probert, L, Sfacteria, A, Siren, A, Talan, M, Thiemermann, C, Westenbrink, D, Yaqoob, M, Zhu, C, Lipton, SA, Hand, CC, Newton, SS, Zhu, C., CAVALETTI, GUIDO ANGELO, Ghezzi, P, Bernaudinb, M, Bianchic, R, Blomgren, K, Brines, M, Campana, W, Cavaletti, G, Cerami, A, Chopp, M, Coleman, T, Digicaylioglu, M, Ehrenreich, H, Erbayraktar, S, Erbayraktar, Z, Gassmann, M, Genc, S, Gokmen, N, Grasso, G, Juul, S, Lipton, S, Hand, C, Latini, R, Lauria, G, Leist, M, Newton, S, Petit, E, Probert, L, Sfacteria, A, Siren, A, Talan, M, Thiemermann, C, Westenbrink, D, Yaqoob, M, Zhu, C, Lipton, SA, Hand, CC, Newton, SS, Zhu, C., and CAVALETTI, GUIDO ANGELO

Published
2010

50. Erythropoietin: not just about erythropoiesis

Author

Ghezzi, Pietro, Bernaudin, Myriam, Bianchi, Roberto, Blomgren, Klas, Brines, M, Campana, W, Cavaletti, G, Cerami, A, Chopp, M, Coleman, T, Digicaylioglu, M, Ehrenreich, H, Erbayraktar, S, Erbayraktar, Z, Gassmann, M, Genc, S, Gokmen, N, Grasso, G, Juul, S, Lipton, S A, Hand, C C, Latini, R, Lauria, G, Leist, M, Newton, S S, Petit, E, Probert, L, Sfacteria, A, Siren, A L, Talan, M, Thiemermann, C, Westenbrink, D, Yaqoob, M, Zhu, C, Ghezzi, Pietro, Bernaudin, Myriam, Bianchi, Roberto, Blomgren, Klas, Brines, M, Campana, W, Cavaletti, G, Cerami, A, Chopp, M, Coleman, T, Digicaylioglu, M, Ehrenreich, H, Erbayraktar, S, Erbayraktar, Z, Gassmann, M, Genc, S, Gokmen, N, Grasso, G, Juul, S, Lipton, S A, Hand, C C, Latini, R, Lauria, G, Leist, M, Newton, S S, Petit, E, Probert, L, Sfacteria, A, Siren, A L, Talan, M, Thiemermann, C, Westenbrink, D, Yaqoob, M, and Zhu, C

Published
2010

Catalog

Books, media, physical & digital resources
See catalog results