1. Asymmetries and Visual Field Summaries as Predictors of Glaucoma in the Ocular Hypertension Treatment Study
- Author
-
Mary B. Hall, John M. Ramocki, Jody R. Piltz-Seymour, Donald F. Everett, Lea Morton, Robert A. Copeland, Stacey S. Goldstein, Michele C. Lim, Harry A. Quigley, Silvia Orengo-Nania, Bernard Becker, Heather Johnson, Richard K. Parrish, Manju Sharma, Teresa A. Long, Karen Clark, David S. Friedman, Cheryl L. Vitelli, Ditte J. Hess, Annisa L. Jamil, Michael A. Kass, Fermin P. Ballesteros, Lisa Levin, Fortunata Darmody, Carol J. Pollack-Rundle, Hina N. Ahmed, Celso Tello, Shan C. Lin, Maria Cristina Wells-Albornoz, Robb R. Shrader, Laura L. Schulz, Betsy Hornbeck, Ellen Long, Donald J. Zack, Jo Anne Katz, Nina C. Mondoc, Kathleen A. Lamping, Robert J. Derick, Julia A. Beiser, Felicia Keel, Kathryn R. Sherman, Allan J. Flach, John Connett, Alan L. Robin, Ronald L. Gross, Jeffrey M. Liebmann, Joern B. Soltau, Sandy Lear, Terry J. Bergstrom, Ramzi Hemady, Denise M. Owensby, William M. Bourne, Janice T. Petner, Arthur L. Schwartz, Shannan E. Bandermann, Ruth Vandenbroucke, Michelle A. Tehranisa, James D. Brandt, Linda M. Zangwill, Douglas R. Anderson, Valerie Margol, Charles J. Patorgis, Robert Ritch, Ingrid J. Clark, Allan E. Kolker, Osaro A. Okuonghae, John M. O'Grady, Joyce C. Schiffman, Y. P. Dang, Deborah Lee, Melanie Gutkowski, Robin L. Montgomery, Sayoko E. Moroi, Mark B. Sherwood, Rachel Scott, Simon K. Law, Deborah Darnley-Fisch, Mark S Juzych, Eydie Miller, Donald L. Budenz, Camilele M. Hylton, Keri Dirkes, N. Douglas Baker, Steven J. Gedde, Donald A. Abrams, Kimberly E. Cello, Deborah A. Dunn, Pamela M. Frady, Steven L. Mansberger, George A. Cioffi, Paul McManus, Deborah L. Simon, Bettina J. Modica, John L. Keltner, Emily L. Patterson, Myron Yanoff, Marianne L. Perry, Juanjuan Fan, Nancy J. Tvedt, Jean L. Walker, Shelly R. Smith, Kathyrne McKinney, Aldo Fantin, Dale K. Heur, Benita D. Slight, Karen D. Schacht, Francisco Fantes, Mark L. McDermott, Pamela A. Sample, Anjali M. Bhorade, Thomas S. Harbin, Carla J. Siegfried, Salvador Murillo, J. Philip Miller, Shaban Demirel, Marilyn A. Sponzo, Patricia A. Morris, Linda A. Van Conett, Eve J. Higginbotham, Barry R Davis, Michael V. Drake, Sheila M. Rock, Nauman R. Imami, Donna Leef, Madeline L. Del Calvo, Howard S. Weiss, J. Rigby Slight, Cheryl McGill, William J. Feuer, Anne L. Coleman, Dale K. Heuer, Juan Allen, David M. Lehmann, Edward M. Barnett, Clete Clark, Claude L Cowan, Jo Anne M Fraser, Irvin P. Pollack, Chris A. Johnson, Paul Weber, Mary Jameson, Jo Ann A Giaconi, Ivan R. Schwab, Sandra Quirin, David C. Herman, Montana L. Hooper, Judit Mohay, Steven M. Kymes, Bhupinder S. Dhillon, Julie M. Wright, Elizabeth Carnegie, Becky A. Nielsen, Ronald Munson, Monica Y. Allen, Teresa A. Roediger, M. Roy Wilson, G. Richard Bennett, Robert N. Weinreb, John A. Keltner, Allen D. Beck, Mary Bednarski, Henry D. Jampel, Christina A. Bruno, Bobbie Ballenberg, Kevin L. Powdrill, Anastasias Costarides, Anne M. Boeckl, Prithvi S. Sankar, Richard S. Baker, Robyn Priest-Reed, Douglas E. Gaasterland, Gregory L. Skuta, Lindsay C. Bennett, Jeffrey J. Casper, Frank S. Ashburn, Diane Moore, Nathan Congdon, Bret A Hughes, Mae E. Gordon, Robert L. Stamper, Douglas H. Johnson, and Richard A. Levine
- Subjects
Male ,Intraocular pressure ,Time Factors ,genetic structures ,Open angle glaucoma ,Eye disease ,Vision Disorders ,Ocular hypertension ,Glaucoma ,Article ,Risk Factors ,medicine ,Psychophysics ,Humans ,Antihypertensive Agents ,Intraocular Pressure ,Monocular ,business.industry ,Middle Aged ,Prognosis ,medicine.disease ,eye diseases ,Visual field ,Visual Field Tests ,Optometry ,Female ,Ocular Hypertension ,sense organs ,Visual Fields ,business ,Glaucoma, Open-Angle - Abstract
To evaluate whether baseline visual field data and asymmetries between eyes predict the onset of primary open-angle glaucoma (POAG) in Ocular Hypertension Treatment Study (OHTS) participants.A new index, mean prognosis (MP), was designed for optimal combination of visual field thresholds, to discriminate between eyes that developed POAG from eyes that did not. Baseline intraocular pressure (IOP) in fellow eyes was used to construct measures of IOP asymmetry. Age-adjusted baseline thresholds were used to develop indicators of visual field asymmetry and summary measures of visual field defects. Marginal multivariate failure time models were constructed that relate the new index MP, IOP asymmetry, and visual field asymmetry to POAG onset for OHTS participants.The marginal multivariate failure time analysis showed that the MP index is significantly related to POAG onset (P0.0001) and appears to be a more highly significant predictor of POAG onset than either mean deviation (MD; P = 0.17) or pattern standard deviation (PSD; P = 0.046). A 1-mm Hg increase in IOP asymmetry between fellow eyes is associated with a 17% increase in risk for development of POAG. When threshold asymmetry between eyes existed, the eye with lower thresholds was at a 37% greater risk of development of POAG, and this feature was more predictive of POAG onset than the visual field index MD, though not as strong a predictor as PSD.The MP index, IOP asymmetry, and binocular test point asymmetry can assist in clinical evaluation of eyes at risk of development of POAG.
- Published
- 2006
- Full Text
- View/download PDF