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Asymmetries and Visual Field Summaries as Predictors of Glaucoma in the Ocular Hypertension Treatment Study

Authors :
Mary B. Hall
John M. Ramocki
Jody R. Piltz-Seymour
Donald F. Everett
Lea Morton
Robert A. Copeland
Stacey S. Goldstein
Michele C. Lim
Harry A. Quigley
Silvia Orengo-Nania
Bernard Becker
Heather Johnson
Richard K. Parrish
Manju Sharma
Teresa A. Long
Karen Clark
David S. Friedman
Cheryl L. Vitelli
Ditte J. Hess
Annisa L. Jamil
Michael A. Kass
Fermin P. Ballesteros
Lisa Levin
Fortunata Darmody
Carol J. Pollack-Rundle
Hina N. Ahmed
Celso Tello
Shan C. Lin
Maria Cristina Wells-Albornoz
Robb R. Shrader
Laura L. Schulz
Betsy Hornbeck
Ellen Long
Donald J. Zack
Jo Anne Katz
Nina C. Mondoc
Kathleen A. Lamping
Robert J. Derick
Julia A. Beiser
Felicia Keel
Kathryn R. Sherman
Allan J. Flach
John Connett
Alan L. Robin
Ronald L. Gross
Jeffrey M. Liebmann
Joern B. Soltau
Sandy Lear
Terry J. Bergstrom
Ramzi Hemady
Denise M. Owensby
William M. Bourne
Janice T. Petner
Arthur L. Schwartz
Shannan E. Bandermann
Ruth Vandenbroucke
Michelle A. Tehranisa
James D. Brandt
Linda M. Zangwill
Douglas R. Anderson
Valerie Margol
Charles J. Patorgis
Robert Ritch
Ingrid J. Clark
Allan E. Kolker
Osaro A. Okuonghae
John M. O'Grady
Joyce C. Schiffman
Y. P. Dang
Deborah Lee
Melanie Gutkowski
Robin L. Montgomery
Sayoko E. Moroi
Mark B. Sherwood
Rachel Scott
Simon K. Law
Deborah Darnley-Fisch
Mark S Juzych
Eydie Miller
Donald L. Budenz
Camilele M. Hylton
Keri Dirkes
N. Douglas Baker
Steven J. Gedde
Donald A. Abrams
Kimberly E. Cello
Deborah A. Dunn
Pamela M. Frady
Steven L. Mansberger
George A. Cioffi
Paul McManus
Deborah L. Simon
Bettina J. Modica
John L. Keltner
Emily L. Patterson
Myron Yanoff
Marianne L. Perry
Juanjuan Fan
Nancy J. Tvedt
Jean L. Walker
Shelly R. Smith
Kathyrne McKinney
Aldo Fantin
Dale K. Heur
Benita D. Slight
Karen D. Schacht
Francisco Fantes
Mark L. McDermott
Pamela A. Sample
Anjali M. Bhorade
Thomas S. Harbin
Carla J. Siegfried
Salvador Murillo
J. Philip Miller
Shaban Demirel
Marilyn A. Sponzo
Patricia A. Morris
Linda A. Van Conett
Eve J. Higginbotham
Barry R Davis
Michael V. Drake
Sheila M. Rock
Nauman R. Imami
Donna Leef
Madeline L. Del Calvo
Howard S. Weiss
J. Rigby Slight
Cheryl McGill
William J. Feuer
Anne L. Coleman
Dale K. Heuer
Juan Allen
David M. Lehmann
Edward M. Barnett
Clete Clark
Claude L Cowan
Jo Anne M Fraser
Irvin P. Pollack
Chris A. Johnson
Paul Weber
Mary Jameson
Jo Ann A Giaconi
Ivan R. Schwab
Sandra Quirin
David C. Herman
Montana L. Hooper
Judit Mohay
Steven M. Kymes
Bhupinder S. Dhillon
Julie M. Wright
Elizabeth Carnegie
Becky A. Nielsen
Ronald Munson
Monica Y. Allen
Teresa A. Roediger
M. Roy Wilson
G. Richard Bennett
Robert N. Weinreb
John A. Keltner
Allen D. Beck
Mary Bednarski
Henry D. Jampel
Christina A. Bruno
Bobbie Ballenberg
Kevin L. Powdrill
Anastasias Costarides
Anne M. Boeckl
Prithvi S. Sankar
Richard S. Baker
Robyn Priest-Reed
Douglas E. Gaasterland
Gregory L. Skuta
Lindsay C. Bennett
Jeffrey J. Casper
Frank S. Ashburn
Diane Moore
Nathan Congdon
Bret A Hughes
Mae E. Gordon
Robert L. Stamper
Douglas H. Johnson
Richard A. Levine
Source :
Investigative Opthalmology & Visual Science. 47:3896
Publication Year :
2006
Publisher :
Association for Research in Vision and Ophthalmology (ARVO), 2006.

Abstract

To evaluate whether baseline visual field data and asymmetries between eyes predict the onset of primary open-angle glaucoma (POAG) in Ocular Hypertension Treatment Study (OHTS) participants.A new index, mean prognosis (MP), was designed for optimal combination of visual field thresholds, to discriminate between eyes that developed POAG from eyes that did not. Baseline intraocular pressure (IOP) in fellow eyes was used to construct measures of IOP asymmetry. Age-adjusted baseline thresholds were used to develop indicators of visual field asymmetry and summary measures of visual field defects. Marginal multivariate failure time models were constructed that relate the new index MP, IOP asymmetry, and visual field asymmetry to POAG onset for OHTS participants.The marginal multivariate failure time analysis showed that the MP index is significantly related to POAG onset (P0.0001) and appears to be a more highly significant predictor of POAG onset than either mean deviation (MD; P = 0.17) or pattern standard deviation (PSD; P = 0.046). A 1-mm Hg increase in IOP asymmetry between fellow eyes is associated with a 17% increase in risk for development of POAG. When threshold asymmetry between eyes existed, the eye with lower thresholds was at a 37% greater risk of development of POAG, and this feature was more predictive of POAG onset than the visual field index MD, though not as strong a predictor as PSD.The MP index, IOP asymmetry, and binocular test point asymmetry can assist in clinical evaluation of eyes at risk of development of POAG.

Details

ISSN :
15525783
Volume :
47
Database :
OpenAIRE
Journal :
Investigative Opthalmology & Visual Science
Accession number :
edsair.doi.dedup.....6e6090552ddbd3d3bd62daeddf1df4b6
Full Text :
https://doi.org/10.1167/iovs.05-0469