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1. Age-stratified and blood-pressure-stratified effects of blood-pressure-lowering pharmacotherapy for the prevention of cardiovascular disease and death: an individual participant-level data meta-analysis

Author

Rahimi, Kazem, Bidel, Zeinab, Nazarzadeh, Milad, Copland, Emma, Canoy, Dexter, Wamil, Malgorzata, Majert, Jeannette, McManus, Richard, Adler, Amanda, Agodoa, Larry, Algra, Ale, Asselbergs, Folkert W, Beckett, Nigel S, Berge, Eivind, Black, Henry, Boersma, Eric, Brouwers, Frank P J, Brown, Morris, Brugts, Jasper J, Bulpitt, Christopher J, Byington, Robert P, Cushman, William C, Cutler, Jeffrey, Devereaux, Richard B, Dwyer, Jamie P, Estacio, Ray, Fagard, Robert, Fox, Kim, Fukui, Tsuguya, Gupta, Ajay K, Holman, Rury R, Imai, Yutaka, Ishii, Masao, Julius, Stevo, Kanno, Yoshihiko, Kjeldsen, Sverre E, Kostis, John, Kuramoto, Kizuku, Lanke, Jan, Lewis, Edmund, Lewis, Julia B, Lievre, Michel, Lindholm, Lars H, Lueders, Stephan, MacMahon, Stephen, Mancia, Giuseppe, Matsuzaki, Masunori, Mehlum, Maria H, Nissen, Steven, Ogawa, Hiroshi, Ogihara, Toshio, Ohkubo, Takayoshi, Palmer, Christopher R, Patel, Anushka, Pfeffer, Marc Allan, Pitt, Bertram, Poulter, Neil R, Rakugi, Hiromi, Reboldi, Gianpaolo, Reid, Christopher, Remuzzi, Giuseppe, Ruggenenti, Piero, Saruta, Takao, Schrader, Joachim, Schrier, Robert, Sever, Peter, Sleight, Peter, Staessen, Jan A, Suzuki, Hiromichi, Thijs, Lutgarde, Ueshima, Kenji, Umemoto, Seiji, van Gilst, Wiek H, Verdecchia, Paolo, Wachtell, Kristian, Whelton, Paul, Wing, Lindon, Woodward, Mark, Yui, Yoshiki, Yusuf, Salim, Zanchetti, Alberto, Zhang, Zhen-Yu, Anderson, Craig, Baigent, Colin, Brenner, Barry Morton, Collins, Rory, de Zeeuw, Dick, Lubsen, Jacobus, Malacco, Ettore, Neal, Bruce, Perkovic, Vlado, Rodgers, Anthony, Rothwell, Peter, Salimi-Khorshidi, Gholamreza, Sundström, Johan, Turnbull, Fiona, Viberti, Giancarlo, Wang, Jiguang, Chalmers, John, Davis, Barry R, Pepine, Carl J, and Teo, Koon K

Published
2021
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6. Association of education and feedback on hypertension management with risk for stroke and cardiovascular disease

Author

Brunström, Mattias, Ng, Nawi, Dahlström, John, Lindholm, Lars H., Norberg, Margareta, Nyström, Lennarth, Weinehall, Lars, Carlberg, Bo, Brunström, Mattias, Ng, Nawi, Dahlström, John, Lindholm, Lars H., Norberg, Margareta, Nyström, Lennarth, Weinehall, Lars, and Carlberg, Bo

Abstract

PURPOSE: Education and feedback on hypertension management has been associated with improved hypertension control. This study aimed to assess the effectiveness of such interventions to reduce the risk of stroke and cardiovascular events. MATERIALS AND METHODS: Individuals ≥18 years with a blood pressure (BP) recording in Västerbotten or Södermanland County during the study period 2001 to 2009 were included in 108 serial cohort studies, each with 24 months follow-up. The primary outcome was risk of first-ever stroke in Västerbotten County (intervention) compared with Södermanland County (control). Secondary outcomes were first-ever major adverse cardiovascular event (MACE), myocardial infarction, and heart failure, as well as all-cause and cardiovascular mortality. All outcomes were analysed using time-to-event data included in a Cox proportional hazards model adjusted for age, sex, hypertension, diabetes, coronary artery disease, atrial fibrillation, systolic BP at inclusion, marital status, and disposable income. RESULTS: A total of 121 365 individuals (mean [SD] age at inclusion 61.7 [16.3] years; 59.9% female; mean inclusion BP 142.3/82.6 mmHg) in the intervention county were compared to 131 924 individuals (63.6 [16.2] years; 61.2% female; 144.1/81.1 mmHg) in the control county. A first-ever stroke occurred in 2 823 (2.3%) individuals in the intervention county, and 3 584 (2.7%) individuals in the control county (adjusted hazard ratio 0.96, 95% CI 0.90 to 1.03). No differences were observed for MACE, myocardial infarction or heart failure, whereas all-cause mortality (HR 0.91, 95% CI 0.87 to 0.95) and cardiovascular mortality (HR 0.91, 95% CI 0.85 to 0.98) were lower in the intervention county. CONCLUSIONS: This study does not support an association between education and feedback on hypertension management to primary care physicians and the risk for stroke or cardiovascular outcomes. The observed differences for mortality outcomes should be interpreted with caut

Published
2022
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7. Työkaluja näyttöön perustuvien menetelmien käyttöönoton edistämiseksi

Author

Lindholm, Lars H., Laitila, Minna, Tampere University, Kliininen lääketiede, and Seinäjoen keskussairaala VA

Subjects
3142 Kansanterveystiede, ympäristö ja työterveys
Abstract

Näyttöön perustuvien menetelmien käyttöönotolla eli implementoinnilla pyritään parantamaan terveydenhuollon vaikuttavuutta ja laatua. Ohjelmat menetelmien jalkauttamiseksi organisaatioiden palveluvalikoimaan kohtaavat usein haasteita, kuten puutteellista yhteisymmärrystä eri sidosryhmien välillä. Implementointiohjelmien tuloksellisuudessa olisikin usein toivomisen varaa, ja menetelmien pysyvyyden varmistaminen palveluvalikoimassa on osoittautunut erityisen vaativaksi. Yhteisymmärrystä voidaan rakentaa ohjelman yhteisellä valmistelulla tärkeimpien sidosryhmien kesken. Oleellista on löytää yhteinen näkemys kysymyksiin miksi, mitä ja miten on tarkoitus implementoida. Linjajohdolla on keskeinen rooli ohjelmien tuloksellisessa läpiviennissä. Käyttöön otetut menetelmät ja muut toiminnot pysyvät terveydenhuollon organisaation palveluvalikoimassa implementointiohjelmien jälkeen vain, jos organisaatio on luonut niitä ylläpitävät pysyvät rakenteet ja työnjohdolliset menettelyt, esimerkiksi koulutuspolun uusille työntekijöille. publishedVersion

Published
2022

12. Lessons from STOP-Hypertension

Author

Ekbom, Tord, Lindholm, Lars H., Hansson, Lennart, Dahlöf, Björn, Linjer, Erland, Scherstén, Bengt, Wester, Per-Olov, Leonetti, Gastone, editor, and Cuspidi, Cesare, editor

Published
1994
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13. Impact of Comorbid Alcohol Use Disorder on Health-Related Quality of Life Among Patients With Depressive Symptoms

Author

Luoto, Kaisa E., Lindholm, Lars H., Koivukangas, Antti, Lassila, Antero, Sintonen, Harri, Leinonen, Esa, Kampman, Olli, Clinicum, Harri Sintonen Research Group, Department of Public Health, University of Helsinki, HYKS erva, Department of Psychiatry, Tampere University, Clinical Medicine, Department of Adolescent Psychiatry, Seinäjoen keskussairaala VA, and Department of Psychotic Disorders

Subjects
Psychiatry, INVENTORY, alcohol use disorder, CARE, motivational interviewing, Clinical Trial, humanities, 3124 Neurology and psychiatry, PREVALENCE, Psychiatry and Mental health, comorbidity, quality of life, DRINKING, mental disorders, depression, behavioral activation, AUDIT
Abstract

Publisher Copyright: © Copyright © 2021 Luoto, Lindholm, Koivukangas, Lassila, Sintonen, Leinonen and Kampman. Background and Aim: In psychiatric clinical practice, comorbidity of depression and alcohol use disorder (AUD) is common. Both disorders have a negative impact on health-related quality of life (HRQoL) in general population. However, research on the impact of comorbid AUD on HRQoL among clinically depressed patients is limited. The purpose of this study was to explore the impact of a psychosocial treatment intervention on HRQoL for depressive patients in specialized psychiatric care with a special focus on the impact of AUD on HRQoL. Material and Methods: Subjects were 242 patients of the Ostrobothnia Depression Study (ClinicalTrials.gov Identifier NCT02520271). Patients referred to specialized psychiatric care who scored at least 17 points on the Beck Depression Inventory at baseline and who had no psychotic disorders were included in the ODS. The treatment intervention in ODS comprised behavioral activation for all but began with motivational interviewing for those with AUD. HRQoL was assessed regularly during 24-month follow-up by the 15D instrument. In the present study, HRQoL of ODS patients with or without AUD was compared and the factors explaining 15D score analyzed with a linear mixed model. In order to specify the impact of clinical depression on HRQoL during the early phase of treatment intervention, a general population sample of the Finnish Health 2011 Survey was used as an additional reference group. Results: HRQoL improved among all ODS study sample patients regardless of comorbid AUD during the first year of follow-up. During 12–24 months of follow-up the difference between groups was seen as HRQoL continued to improve only among the non-AUD patients. A combination of male gender, anxiety disorder, and AUD was associated with the poorest HRQoL in this sample. In combined sample analyses with the reference group, clinical depression had an impact on HRQoL in short-term follow-up regardless of the treatment intervention. Conclusions: This study suggests that, in terms of improvement in HRQoL, the heterogenous group of depressive patients in specialized psychiatric care can be successfully treated with behavioral activation in combination with motivational interviewing for those with AUD. Clinical Trial Registration: ClinicalTrials.gov Identifier: NCT02520271. Ostrobothnia Depression Study (ODS). A Naturalistic Follow-up Study on Depression and Related Substance Use Disorders. (2015). Available online at: https://clinicaltrials.gov/ct2/show/NCT02520271.

Published
2021

17. Prognostic importance of hemoglobin in hypertensive patients with electrocardiographic left ventricular hypertrophy: The Losartan Intervention For End point reduction in hypertension (LIFE) study

Author

Olsen, Michael Hecht, Wachtell, Kristian, Beevers, Gareth, Dahlöf, Björn, Devereux, Richard B., de Faire, Ulf, Fyhrquist, Frej, Ibsen, Hans, Kjeldsen, Sverre E., Lederballe-Pedersen, Ole, Lindholm, Lars H., Narayan, Puneet, Nieminen, Markku S., Omvik, Per, Oparil, Suzanne, and Wedel, Hans

Published
2009
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18. Age-stratified and blood-pressure-stratified effects of blood-pressure-lowering pharmacotherapy for the prevention of cardiovascular disease and death:an individual participant-level data meta-analysis

Author

Rahimi, Kazem, Bidel, Zeinab, Nazarzadeh, Milad, Copland, Emma, Canoy, Dexter, Wamil, Malgorzata, Majert, Jeannette, McManus, Richard, Adler, Amanda, Agodoa, Larry, Algra, Ale, Asselbergs, Folkert W., Beckett, Nigel S., Berge, Eivind, Black, Henry, Boersma, Eric, Brouwers, Frank P.J., Brown, Morris, Brugts, Jasper J., Bulpitt, Christopher J., Byington, Robert P., Cushman, William C., Cutler, Jeffrey, Devereaux, Richard B., Dwyer, Jamie P., Estacio, Ray, Fagard, Robert, Fox, Kim, Fukui, Tsuguya, Gupta, Ajay K., Holman, Rury R., Imai, Yutaka, Ishii, Masao, Julius, Stevo, Kanno, Yoshihiko, Kjeldsen, Sverre E., Kostis, John, Kuramoto, Kizuku, Lanke, Jan, Lewis, Edmund, Lewis, Julia B., Lievre, Michel, Lindholm, Lars H., Lueders, Stephan, MacMahon, Stephen, Mancia, Giuseppe, Matsuzaki, Masunori, Mehlum, Maria H., Nissen, Steven, Ogawa, Hiroshi, Rahimi, Kazem, Bidel, Zeinab, Nazarzadeh, Milad, Copland, Emma, Canoy, Dexter, Wamil, Malgorzata, Majert, Jeannette, McManus, Richard, Adler, Amanda, Agodoa, Larry, Algra, Ale, Asselbergs, Folkert W., Beckett, Nigel S., Berge, Eivind, Black, Henry, Boersma, Eric, Brouwers, Frank P.J., Brown, Morris, Brugts, Jasper J., Bulpitt, Christopher J., Byington, Robert P., Cushman, William C., Cutler, Jeffrey, Devereaux, Richard B., Dwyer, Jamie P., Estacio, Ray, Fagard, Robert, Fox, Kim, Fukui, Tsuguya, Gupta, Ajay K., Holman, Rury R., Imai, Yutaka, Ishii, Masao, Julius, Stevo, Kanno, Yoshihiko, Kjeldsen, Sverre E., Kostis, John, Kuramoto, Kizuku, Lanke, Jan, Lewis, Edmund, Lewis, Julia B., Lievre, Michel, Lindholm, Lars H., Lueders, Stephan, MacMahon, Stephen, Mancia, Giuseppe, Matsuzaki, Masunori, Mehlum, Maria H., Nissen, Steven, and Ogawa, Hiroshi

Abstract

Background: The effects of pharmacological blood-pressure-lowering on cardiovascular outcomes in individuals aged 70 years and older, particularly when blood pressure is not substantially increased, is uncertain. We compared the effects of blood-pressure-lowering treatment on the risk of major cardiovascular events in groups of patients stratified by age and blood pressure at baseline. Methods: We did a meta-analysis using individual participant-level data from randomised controlled trials of pharmacological blood-pressure-lowering versus placebo or other classes of blood-pressure-lowering medications, or between more versus less intensive treatment strategies, which had at least 1000 persons-years of follow-up in each treatment group. Participants with previous history of heart failure were excluded. Data were obtained from the Blood Pressure Lowering Treatment Triallists' Collaboration. We pooled the data and categorised participants into baseline age groups (<55 years, 55–64 years, 65–74 years, 75–84 years, and ≥85 years) and blood pressure categories (in 10 mm Hg increments from <120 mm Hg to ≥170 mm Hg systolic blood pressure and from <70 mm Hg to ≥110 mm Hg diastolic). We used a fixed effects one-stage approach and applied Cox proportional hazard models, stratified by trial, to analyse the data. The primary outcome was defined as either a composite of fatal or non-fatal stroke, fatal or non-fatal myocardial infarction or ischaemic heart disease, or heart failure causing death or requiring hospital admission. Findings: We included data from 358 707 participants from 51 randomised clinical trials. The age of participants at randomisation ranged from 21 years to 105 years (median 65 years [IQR 59–75]), with 42 960 (12·0%) participants younger than 55 years, 128 437 (35·8%) aged 55–64 years, 128 506 (35·8%) 65–74 years, 54 016 (15·1%) 75–84 years, and 4788 (1·3%) 85 years and older. The hazard ratios for the risk of major cardiovascular events per 5 mm

Published
2021

19. Comparing Hypertension Guidelines [with Reply]

Author

Scanlon, T. J., Luben, R., Lyle, P., Burr, Andrew J., Lindholm, Lars H., Werkö, Lars, Barton, Stuart, Cranney, Mike, Walley, Tom, Fahey, T. P., and Peters, T. J.

Published
1996

20. Pharmacological blood pressure lowering for primary and secondary prevention of cardiovascular disease across different levels of blood pressure: an individual participant-level data meta-analysis

Author

Rahimi, Kazem, primary, Bidel, Zeinab, additional, Nazarzadeh, Milad, additional, Copland, Emma, additional, Canoy, Dexter, additional, Ramakrishnan, Rema, additional, Pinho-Gomes, Ana-Catarina, additional, Woodward, Mark, additional, Adler, Amanda, additional, Agodoa, Larry, additional, Algra, Ale, additional, Asselbergs, Folkert W, additional, Beckett, Nigel S, additional, Berge, Eivind, additional, Black, Henry, additional, Brouwers, Frank P J, additional, Brown, Morris, additional, Bulpitt, Christopher J, additional, Byington, Robert P, additional, Cushman, William C, additional, Cutler, Jeffrey, additional, Devereaux, Richard B, additional, Dwyer, Jamie, additional, Estacio, Ray, additional, Fagard, Robert, additional, Fox, Kim, additional, Fukui, Tsuguya, additional, Gupta, Ajay K, additional, Holman, Rury R, additional, Imai, Yutaka, additional, Ishii, Masao, additional, Julius, Stevo, additional, Kanno, Yoshihiko, additional, Kjeldsen, Sverre E, additional, Kostis, John, additional, Kuramoto, Kizuku, additional, Lanke, Jan, additional, Lewis, Edmund, additional, Lewis, Julia B, additional, Lievre, Michel, additional, Lindholm, Lars H, additional, Lueders, Stephan, additional, MacMahon, Stephen, additional, Mancia, Giuseppe, additional, Matsuzaki, Masunori, additional, Mehlum, Maria H, additional, Nissen, Steven, additional, Ogawa, Hiroshi, additional, Ogihara, Toshio, additional, Ohkubo, Takayoshi, additional, Palmer, Christopher R, additional, Patel, Anushka, additional, Pfeffer, Marc Allan, additional, Pitt, Bertram, additional, Poulter, Neil R, additional, Rakugi, Hiromi, additional, Reboldi, Gianpaolo, additional, Reid, Christopher, additional, Remuzzi, Giuseppe, additional, Ruggenenti, Piero, additional, Saruta, Takao, additional, Schrader, Joachim, additional, Schrier, Robert, additional, Sever, Peter, additional, Sleight, Peter, additional, Staessen, Jan A, additional, Suzuki, Hiromichi, additional, Thijs, Lutgarde, additional, Ueshima, Kenji, additional, Umemoto, Seiji, additional, van Gilst, Wiek H, additional, Verdecchia, Paolo, additional, Wachtell, Kristian, additional, Whelton, Paul, additional, Wing, Lindon, additional, Yui, Yoshiki, additional, Yusuf, Salim, additional, Zanchetti, Alberto, additional, Zhang, Zhen-Yu, additional, Anderson, Craig, additional, Baigent, Colin, additional, Brenner, Barry Morton, additional, Collins, Rory, additional, de Zeeuw, Dick, additional, Lubsen, Jacobus, additional, Malacco, Ettore, additional, Neal, Bruce, additional, Perkovic, Vlado, additional, Rodgers, Anthony, additional, Rothwell, Peter, additional, Salimi-Khorshidi, Gholamreza, additional, Sundström, Johan, additional, Turnbull, Fiona, additional, Viberti, Giancarlo, additional, Wang, Jiguang, additional, Chalmers, John, additional, Teo, Koon K, additional, Pepine, Carl J, additional, and Davis, Barry R, additional

Published
2021
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22. Additional file 4 of Importance of congruence between communicating and executing implementation programmes: a qualitative study of focus group interviews

Author

Lindholm, Lars H., Laitila, Minna, Lassila, Antero, and Kampman, Olli

Abstract

Additional file 4. The interview guide for the first interviews of Focus Groups 1 and 2 and the process of deriving of the guide (Table A). The interview guide for the second interview of Focus Group 1 (Table B).

Published
2020
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26. Association of Physician Education and Feedback on Hypertension Management With Patient Blood Pressure and Hypertension Control

Author

Brunström, Mattias, Ng, Nawi, Dahlström, John, Lindholm, Lars H., Lönnberg, Göran, Norberg, Margareta, Nyström, Lennarth, Weinehall, Lars, Carlberg, Bo, Brunström, Mattias, Ng, Nawi, Dahlström, John, Lindholm, Lars H., Lönnberg, Göran, Norberg, Margareta, Nyström, Lennarth, Weinehall, Lars, and Carlberg, Bo

Abstract

Importance: Elevated systolic blood pressure (SBP) is the most important risk factor for premature death worldwide. However, hypertension detection and control rates continue to be suboptimal. Objective: To assess the association of education and feedback to primary care physicians with population-level SBP and hypertension control rates. Design, Setting, and Participants: This pooled series of 108 population-based cohort studies involving 283 079 patients used data from primary care centers in 2 counties (Västerbotten and Södermanland) in Sweden from 2001 to 2009. Participants were individuals aged 18 years or older who had their blood pressure (BP) measured and recorded in either county during the intervention period. All analyses were performed in February 2019. Exposures: An intervention comprising education and feedback for primary care physicians in Västerbotten County (intervention group) compared with usual care in Södermanland County (control group). Main Outcomes and Measures: Difference in mean SBP levels between counties and likelihood of hypertension control in the intervention county compared with the control county during 24 months of follow-up. Results: A total of 136 541 unique individuals (mean [SD] age at inclusion, 64.6 [16.1] years; 57.0% female; mean inclusion BP, 142/82 mm Hg) in the intervention county were compared with 146 538 individuals (mean [SD] age at inclusion, 65.7 [15.9] years; 58.3% female; mean inclusion BP, 144/80 mm Hg) in the control county. Mean SBP difference between counties during follow-up, adjusted for inclusion BP and other covariates, was 1.1 mm Hg (95% CI, 1.0-1.1 mm Hg). Hypertension control improved by 8.4 percentage points, and control was achieved in 37.8% of participants in the intervention county compared with 29.4% in the control county (adjusted odds ratio, 1.30; 95% CI, 1.29-1.31). Differences between counties increased during the intervention period and were more pronounced in participants with higher SBP at

Published
2020
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27. Contributors

Author

Acelajado, Maria Czarina, primary, Allcock, Darren M., additional, Allison, Matthew A., additional, Anderson, Craig, additional, Appel, Lawrence J., additional, Arima, Hisatomi, additional, Arnett, Donna K., additional, August, Phyllis, additional, Bakris, George L., additional, Bard, Robert L., additional, Basile, Jan N., additional, Bilo, Grzegorz, additional, Black, Henry R., additional, Bloch, Michael J., additional, Bombelli, Michele, additional, Brook, Robert D., additional, Calhoun, David A., additional, Campbell, Norman R.C., additional, Campbell, Patrick T., additional, Carlberg, Bo, additional, Carter, Barry L., additional, Chalmers, John, additional, Chapman, Neil, additional, Claas, Steven A., additional, Criqui, Michael H., additional, Crook, Errol D., additional, Deedwania, Prakash C., additional, Desai, Mehul, additional, Eagle, Kim A., additional, Elliott, William J., additional, Falkner, Bonita, additional, Flack, John M., additional, Franklin, Stanley S., additional, Freudenberger, Ronald, additional, Frishman, William H., additional, Giles, Thomas D., additional, Gonzalez-Santos, Lourdes, additional, Gorelick, Philip B., additional, Grassi, Guido, additional, Grim, Carlene M., additional, Grim, Clarence E., additional, Grossman, Ehud, additional, Gupta, Rajeev, additional, Ho, P. Michael, additional, Hyman, David J., additional, Izzo, Joseph L., additional, Kokkoris, Panagiotis, additional, Kostis, John B., additional, Krum, Henry, additional, LaRosa, John C., additional, Lazich, Ivana, additional, Levy, Daniel, additional, Levy, Phillip, additional, Liebson, Philip R., additional, Lindholm, Lars H., additional, Lloyd-Jones, Donald M., additional, Lombardi, Carolina, additional, Lynch, Amy I., additional, Mancia, Giuseppe, additional, Materson, Barry J., additional, Messerli, Franz H., additional, Nasser, Samar A., additional, Neal, Bruce, additional, Neaton, James D., additional, Oparil, Suzanne, additional, Parati, Gianfranco, additional, Pavlik, Valory N., additional, Pi-Sunyer, F. Xavier, additional, Podymow, Tiina, additional, Pool, James L., additional, Rehman, Shakaib U., additional, Reidy, James J., additional, Rosendorff, Clive, additional, Sagar, Utpal N., additional, Schlaich, Markus, additional, Sega, Roberto, additional, Setaro, John F., additional, Shah, Hajra Z., additional, Sica, Domenic A., additional, Singh, Manmeet M., additional, Sobotka, Paul A., additional, Sowers, James R., additional, Stockbridge, Norman, additional, Szeto, Ignatius M.Y., additional, Taler, Sandra J., additional, Temple, Robert, additional, Throckmorton, Douglas C., additional, Turnbull, Fiona, additional, Udani, Suneel, additional, Vallbona, Carlos, additional, Vidt, Donald G., additional, Whaley-Connell, Adam T., additional, White, William B., additional, Williams, Bryan, additional, Wilson, Peter W.F., additional, Wong, Nathan D., additional, Young, William F., additional, and Zanchetti, Alberto, additional

Published
2013
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29. Regression of electrocardiographic left ventricular hypertrophy and decreased incidence of new-onset atrial fibrillation in patients with hypertension

Author

Okin, Peter M.' Wachtell, Kristian, Devereux, Richard B., Harris, Katherine E., Jern, Sverker, Kjeldsen, Sverre, Julius, Stevo, Lindholm, Lars H., Nieminen, Markku S., Edelman, Jonathan M., Hille, Darcy A., and Dahlof, Bjorn

Subjects
Heart enlargement -- Prevention, Atrial fibrillation -- Risk factors, Antihypertensive drugs -- Dosage and administration, Cardiac patients -- Drug therapy
Abstract

Trials were conducted to test the hypothesis that in-treatment regression or continued absence of electrocardiographic left ventricular hypertrophy (LVH) during antihypertensive therapy is associated with a decreased incidence of atrial fibrillation, independent of blood pressure and treatment modality. It was concluded that antihypertensive therapy targeted at regression or prevention of electrocardiographic LVH may reduce the incidence of new-onset AF.

Published
2006

30. Effects of losartan on cardiovascular morbidity and mortality in patients with isolated systolic hypertension and left ventricular hypertrophy: a Losartan Intervention For Endpoint Reduction (LIFE) substudy

Author

Kjeldsen, Sverre E., Dahlof, Bjorn, Devereux, Richard B., Julius, Stevo, Aurup, Peter, Edelman, Jonathan, Beevers, Gareth, Faire, Ulf de, Fyhrquist, Frej, Ibsen, Hans, Kristianson, Krister, Lederballe-Pedersen, Ole, Lindholm, Lars H., Nieminen, Markku S., Omvik, Per, Oparil, Suzanne, Snapinn, Steven, and Wedel, Hans

Subjects
Losartan -- Evaluation, Hypertension -- Drug therapy
Abstract

The drug losartan is more effective than atenolol in lowering blood pressure in patients with systolic high blood pressure, according to a study of 1,326 patients. Losartan belongs to a group of drugs called angiotensin II receptor blockers. Although both drugs lowered blood pressure, patients who took losartan were less likely to have a stroke, develop diabetes, or die from cardiovascular disease.

Published
2002

33. Contributors

Author

Asmar, Roland, primary, Basile, Jan N., additional, Beevers, D.G., additional, Beilin, Lawrence J., additional, Bilo, Grzegorz, additional, Black, Henry R., additional, Boerrigter, Guido, additional, Bone, Lee R., additional, Brunner, Hans, additional, Burnett, John C., additional, Calhoun, David A., additional, Campese, Vito M., additional, Carey, Robert M., additional, Caro, J. Jaime, additional, Carretero, Oscar A., additional, Chappell, Mark C., additional, Chrysant, George S., additional, Cutler, Jeffrey A., additional, Dahlöf, Björn, additional, da Silva, Alexandre A., additional, de Faire, Ulf, additional, Delgado, Maria Carolina, additional, Devereux, Richard B., additional, Diamond, Joseph A., additional, DiPette, Donald J., additional, Diz, Debra I., additional, Edelman, Jonathan M., additional, Elliott, William J., additional, Ekman, Steffan, additional, Falkner, Bonita, additional, Fan, William L., additional, Fenichel, Robert R., additional, Ferrario, Carlos M., additional, Franklin, Stanley S., additional, Freis, Edward D., additional, Frishman, William H., additional, Frohlich, Edward D., additional, Funder, John W., additional, Fyhrquist, Frej, additional, Gamba, Gerardo, additional, Gami, Apoor S., additional, Gavras, Haralambos, additional, Gavras, Irene, additional, Gehr, Todd W.B., additional, Gleim, Gilbert W., additional, Hall, John E., additional, Hanes, Donna S., additional, Harrap, tephen B., additional, Harris, Katherine E., additional, Haus, Erhard, additional, Hermida, Ramon C., additional, Hill, Martha N., additional, Ibsen, Hans, additional, Intengan, Hope, additional, Izzo, Joseph L., additional, Jennings, Garry L.R., additional, Johnson, Ernest F., additional, Johnston, Colin I., additional, Jones, Daniel W., additional, Julius, Stevo, additional, Kannel, William B., additional, Katki, Khurshed A., additional, Kjeldsen, Sverre E., additional, Kleyman, Thomas R., additional, Knepper, Mark A., additional, Kokkoris, Panagiotis, additional, Kostis, John B., additional, Krakoff, Lawrence R., additional, Kristianson, Krister J., additional, Kuo, Jay J., additional, Lakkis, Jay, additional, Laragh, John H., additional, Levine, David M., additional, Light, Kathleen C., additional, Lindholm, Lars H., additional, Liu, Jiankang, additional, Lüscher, Thomas F., additional, Mancia, Giuseppe, additional, Mansoor, George A., additional, McCarron, David A., additional, McGuire, Heather L., additional, McInnes, Gordon T., additional, McMahon, Ellen G., additional, Meyer, Renee P., additional, Miller, Nancy Houston, additional, Nadim, Mitra K., additional, Nesbitt, Shawna D., additional, Neutel, Joel M., additional, Nieminen, Markku S., additional, Nussberger, Jürg, additional, Omvik, Per, additional, Oparil, Suzanne, additional, Opie, Lionel H., additional, Osterberg, Lars, additional, Parati, Gianfranco, additional, Payne, Krista A., additional, Pedersen, Ole Lederballe, additional, Phillips, Robert A., additional, Pi-Sunyer, Xavier, additional, Plat, Francis, additional, Pool, James L., additional, Portaluppi, Francesco, additional, Prisant, L. Michael, additional, Puddey, Ian B., additional, Raj, Satish R., additional, Reaven, Gerald M., additional, Reeves, Scott T., additional, Reinberg, Alain, additional, Reiser, Ira W., additional, Reudelhuber, Timothy L., additional, Reusser, Molly E., additional, Reves, J.G., additional, Rhaleb, Nour-Eddine, additional, Robertson, David, additional, Roccella, Edward J., additional, Rudd, Peter, additional, Ruddy, Michael C., additional, Ruilope, Luis Miguel, additional, Schiffrin, Ernesto L., additional, Schirger, John A., additional, Schork, M. Anthony, additional, Shepherd, Alexander M.M., additional, Sica, Domenic A., additional, Siragy, Helmy M., additional, Smith, Beverly A., additional, Smolensky, Michael H., additional, Snapinn, Steven, additional, Somers, Virend K., additional, Spieker, Lukas E., additional, Spitalewitz, Samuel, additional, Stolt, Pelle, additional, Supowit, Scott C., additional, Svetkey, Laura P., additional, Taler, Sandra J., additional, Tallam, Lakshmi S., additional, Tallant, E. Ann, additional, Tikellis, Chris, additional, Turnbull, Fiona, additional, Vidt, Donald G., additional, Watson, Ralph E., additional, Weber, Michael A., additional, Wedel, Hans, additional, Weder, Alan B., additional, Weinberger, Myron H., additional, Weir, Matthew R., additional, White, William B., additional, Wofford, Marion R., additional, Wong, Nathan D., additional, Wright, Jackson T., additional, Yang, Xiao-Ping, additional, Young, William F., additional, Zanchetti, Alberto, additional, and Zhao, Huawei, additional

Published
2005
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34. The LIFE Study

Author

Dahlöf, Björn, primary, Devereux, Richard B., additional, Kjeldsen, Sverre E., additional, Julius, Stevo, additional, Beevers, D.G., additional, de Faire, Ulf, additional, Fyhrquist, Frej, additional, Ibsen, Hans, additional, Kristianson, Krister, additional, Pedersen, Ole Lederballe, additional, Lindholm, Lars H., additional, Nieminen, Markku S., additional, Omvik, Per, additional, Oparil, Suzanne, additional, Wedel, Hans, additional, Edelman, Jonathan M., additional, Snapinn, Steve, additional, Harris, Katherine E., additional, and Gleim, Gilbert W., additional

Published
2005
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36. 2007 Guidelines for the management of arterial hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)

Author

Mancia, Giuseppe, De Backer, Guy, Dominiczak, Anna, Cifkova, Renata, Fagard, Robert, Germano, Giuseppe, Grassi, Guido, Heagerty, Anthony M., Kjeldsen, Sverre E., Laurent, Stephane, Narkiewicz, Krzysztof, Ruilope, Luis, Rynkiewicz, Andrzej, Schmieder, Roland E., Struijker Boudier, Harry A.J., Zanchetti, Alberto, Vahanian, Alec, Camm, John, De Caterina, Raffaele, Dean, Veronica, Dickstein, Kenneth, Filippatos, Gerasimos, Funck-Brentano, Christian, Hellemans, Irene, Kristensen, Steen Dalby, McGregor, Keith, Sechtem, Udo, Silber, Sigmund, Tendera, Michal, Widimsky, Petr, Zamorano, Jose Luis, Kjeldsen, Sverre E., Erdine, Serap, Narkiewicz, Krzysztof, Kiowski, Wolfgang, Agabiti-Rosei, Enrico, Ambrosioni, Ettore, Lindholm, Lars H., Mancia, Giuseppe, Manolis, Athanasios, Nilsson, Peter M., Redon, Josep, Struijker-Boudier, Harry A.J., Viigimaa, Margus, Filippatos, Gerasimos, Adamopoulos, Stamatis, Bertomeu, Vicente, Clement, Denis, Erdine, Serap, Farsang, Csaba, Gaita, Dan, Kiowski, Wolfgang, Lip, Gregory, Mallion, Jean-Michel, Manolis, Athanasios J., O'Brien, Eoin, Ponikowski, Piotr, Ruschitzka, Frank, Tamargo, Juan, van Zwieten, Pieter, Waeber, Bernard, and Williams, Bryan

Published
2007

39. The impact of serum uric acid on cardiovascular outcomes in the LIFE study

Author

Høieggen, Aud, Alderman, Michael H., Kjeldsen, Sverre E., Julius, Stevo, Devereux, Richard B., de Faire, Ulf, Fyhrquist, Frej, Ibsen, Hans, Kristianson, Krister, Lederballe-Pedersen, Ole, Lindholm, Lars H., Nieminen, Markku S., Omvik, Per, Oparil, Suzanne, Wedel, Hans, Chen, Cong, Dahlöf, Björn, and for the LIFE Study Group

Published
2004
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43. Albuminuria and Cardiovascular Risk in Hypertensive Patients with Left Ventricular Hypertrophy: The LIFE Study

Author

Wachtell, Kristian, Ibsen, Hans, Olsen, Michael H., Borch-Johnsen, Knut, Lindholm, Lars H., Mogensen, Carl Erik, Dahlöf, Björn, Devereux, Richard B., Beevers, Gareth, de Faire, Ulf, Fyhrquist, Frej, Julius, Stevo, Kjeldsen, Sverre E., Kristianson, Krister, Lederballe-Pedersen, Ole, Nieminen, Markku S., Okin, Peter M., Omvik, Per, Oparil, Suzanne, Wedel, Hans, Snapinn, Steven M., and Aurup, Peter

Published
2003

44. Effects of Losartan or Atenolol in Hypertensive Patients without Clinically Evident Vascular Disease: A Substudy of the LIFE Randomized Trial

Author

Devereux, Richard B., Dahlöf, Björn, Kjeldsen, Sverre E., Julius, Stevo, Aurup, Peter, Beevers, Gareth, Edelman, Jonathan M., de Faire, Ulf, Fyhrquist, Frej, Sigrid Helle Berg, Ibsen, Hans, Kristianson, Krister, Lederballe-Pedersen, Ole, Lindholm, Lars H., Nieminen, Markku S., Omvik, Per, Oparil, Suzanne, Snapinn, Steven, and Wedel, Hans

Published
2003

47. Stroke outcomes in life

Author

Kjeldsen, Sverre E., Julius, Stevo, Devereux, Richard B., Lindholm, Lars H., Dahlöf, Björn, Gleim, Gilbert W., Beevers, Gareth, Edelman, Jonathan M., de Faire, Ulf, Fyhrquist, Frej, Ibsen, Hans, Kristianson, Krister, Lederballe-Pedersen, Ole, Nieminen, Markku S., Omvik, Per, Oparil, Suzanne, Harris, Katherine E., and Snapinn, Steven M.

Published
2003
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