66 results on '"Lin-Fu Liang"'
Search Results
2. Chemical and Biological Investigation on the Potential Ornamental Plant Ophiorrhiza chinensis
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Qing Bu, Zeng-Yue Ge, and Lin-Fu Liang
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Ophiorrhiza chinensis H.S. Lo (Rubiaceae) ,phytochemistry ,bioactivity ,molecular docking study ,Agriculture - Abstract
An investigation of the potential ornamental plant Ophiorrhiza chinensis H.S. Lo (Rubiaceae) was conducted, which resulted in the discovery of eight structurally diverse compounds, including two triterpenes, two steroids, two anthraquinones, one alkaloid, and one coumarin. These chemical constituents were isolated by repeated column chromatography and identified by analysis of their NMR spectral data. All of these substances were found in this species for the first time, and four of them were first isolated from the genus Ophiorrhiza. The chemotaxonomic importance of these isolates was discussed, indicating four chemotaxonomic markers for O. chinensis. The tyrosinase inhibitory activity of these isolates was evaluated by a colorimetric method. As a result, six phytochemicals demonstrated moderate tyrosinase inhibitory effects with IC50 values ranging from 25.7 μM to 68.1 μM. Moreover, the binding modes between the active compounds and the mushroom tyrosinase were analyzed preliminarily assisted by molecular docking calculations. This study filled up the knowledge gap of the unreported phytochemical and pharmacological profiles of secondary metabolites from the species O. chinensis.
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- 2024
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3. Functions of enzyme domains in 2-methylisoborneol biosynthesis and enzymatic synthesis of non-natural analogs
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Binbin Gu, Lin-Fu Liang, and Jeroen S. Dickschat
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biosynthesis ,enzymes ,isotopes ,substrate analogs ,terpenes ,Science ,Organic chemistry ,QD241-441 - Abstract
Two aspects of the biosynthesis of the non-canonical terpene synthase for 2-methylisoborneol have been studied. Several 2-methylisoborneol synthases have a proline-rich N-terminal domain of unknown function. The results presented here demonstrate that this domain leads to a reduced enzyme activity, in addition to its ability to increase long-term solubility of the protein. Furthermore, the substrate scope of the 2-methylisoborneol synthase was investigated through enzyme incubations with several substrate analogs, giving access to two C12 monoterpenoids. Implications on the stereochemical course of the terpene cyclisation by 2-methylisoborneol synthase are discussed.
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- 2023
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4. Spongia Sponges: Unabated Sources of Novel Secondary Metabolites
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Qi-Bin Yang and Lin-Fu Liang
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marine sponges ,Spongia ,secondary metabolites ,bioactivities ,Biology (General) ,QH301-705.5 - Abstract
Marine sponges of the genus Spongia have proven to be unabated sources of novel secondary metabolites with remarkable scaffold diversities and significant bioactivities. The discovery of chemical substances from Spongia sponges has continued to increase over the last few years. The current work provides an up-to-date literature survey and comprehensive insight into the reported metabolites from the members of the genus Spongia, as well as their structural features, biological activities, and structure–activity relationships when available. In this review, 222 metabolites are discussed based on published data from the period from mid-2015 to the beginning of 2024. The compounds are categorized into sesquiterpenes, diterpenes, sesterterpenes, meroterpenes, linear furanoterpenes, steroids, alkaloids, and other miscellaneous substances. The biological effects of these chemical compositions on a vast array of pharmacological assays including cytotoxic, anti-inflammatory, antibacterial, neuroprotective, protein tyrosine phosphatase 1B (PTP1B)-inhibitory, and phytoregulating activities are also presented.
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- 2024
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5. α-Glucosidase Inhibitory Phytochemical Components of Chinese Endemic Plant Whitfordiodendron filipes var. tomentosum
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Jun-Kun Chen, Zeng-Yue Ge, Xiao-Wen Liao, Jun Xue, Lei Wu, and Lin-Fu Liang
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triterpene ,steroid ,hypoglycemic bioactivity ,molecular docking ,Botany ,QK1-989 - Abstract
Whitfordiodendron filipes var. tomentosum is an endemic plant in China. There have been no chemical or pharmacological studies of this plant reported before. In the current research, eight triterpenes and two steroids were obtained. Their structures were established by the analysis of NMR data and comparison with those reported in the literature. These ten structurally diverse compounds comprised five distinct carbon frameworks with different functionalities. The chemotaxonomic significance of these secondary metabolites was discussed, disclosing the common components between the variant W. filipes var. tomentosum and the species W. filipe. Evaluation of α-glucosidase inhibitory activities of these isolates disclosed that compounds 1, 2, 4, and 6 exhibited significant α-glucosidase inhibitory activities (IC50 = 16.6–19.2 μM), which were close in value to the positive control acarbose (IC50 = 11.5 μM). Moreover, the binding modes between the biologically active compounds 1, 2, 4, and 6 and the α-glucosidase protein were preliminarily studied using molecular docking. This study not only showed the chemical and biological profile of the plant W. filipes var. tomentosum but also revealed that these components could be developed as hypoglycemic lead compounds.
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- 2024
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6. Genus Litophyton: A Hidden Treasure Trove of Structurally Unique and Diversely Bioactive Secondary Metabolites
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Xian-Yun Yan, Ling Zhang, Qi-Bin Yang, Zeng-Yue Ge, Lin-Fu Liang, and Yue-Wei Guo
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soft coral ,Litophyton ,secondary metabolites ,terpenes ,bioactivities ,cytotoxicity ,Biology (General) ,QH301-705.5 - Abstract
Marine soft corals are prolific sources of various natural products that have served as a wealthy reservoir of diverse chemical scaffolds with potential as new drug leads. The genus Litophyton contains almost 100 species but only a small proportion of them has been chemically investigated, which calls for more attentions from global researchers. In the current work, 175 secondary metabolites have been discussed, drawing from published data spanning almost five decades, up to July 2023. The studied species of the genus Litophyton resided in various tropical and temperate regions and encompassed a broad range of biologically active natural products including terpenes, steroids, nitrogen-containing metabolites, lipids, and other metabolites. A wide spectrum of pharmacological effects of these compounds had been evaluated, such as cytotoxic, antiviral, antibacterial, antifungal, anti-malarial, antifeedant, anti-inflammatory, molluscicidal, PTP1B inhibitory, insect growth inhibitory, and neuroprotective activities. This review aims to offer an up-to-date survey of the literature and provide a comprehensive understanding of the chemical structures, taxonomical distributions, and biological activities of the reported metabolites from the title genus whenever available.
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- 2023
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7. Lobosteroids A–F: Six New Highly Oxidized Steroids from the Chinese Soft Coral Lobophytum sp.
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Zi-Yi Xia, Man-Man Sun, Yang Jin, Li-Gong Yao, Ming-Zhi Su, Lin-Fu Liang, Hong Wang, and Yue-Wei Guo
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soft coral ,Lobophytum sp. ,steroids ,antibacterial activity ,Biology (General) ,QH301-705.5 - Abstract
To explore the steroidal constituents of the soft coral Lobophytum sp. at the coast of Xuwen County, Guangdong Province, China, a chemical investigation of the above-mentioned soft coral was carried out. After repeated column chromatography over silica gel, Sephadex LH-20, and reversed-phase HPLC, six new steroids, namely lobosteroids A–F (1–6), along with four known compounds 7–10, were obtained. Their structures were determined by extensive spectroscopic analysis and comparison with the spectral data reported in the literature. Among them, the absolute configuration of 1 was determined by X-ray diffraction analysis using Cu Kα radiation. These steroids were characterized by either the presence of an α,β-α′,β′-unsaturated carbonyl, or an α,β-unsaturated carbonyl moiety in ring A, or the existence of a 5α,8α-epidioxy system in ring B, as well as diverse oxidation of side chains. The antibacterial bioassays showed that all isolated steroids exhibited significant inhibitory activities against the fish pathogenic bacteria Streptococcus parauberis FP KSP28, Phoyobacterium damselae FP2244, and Streptococcus parauberis SPOF3K, with IC90 values ranging from 0.1 to 11.0 µM. Meanwhile, compounds 2 and 6–10 displayed potent inhibitory effects against the vancomycin-resistant Enterococcus faecium bacterium G7 with IC90 values ranging from 4.4 to 18.3 µM. Therefore, ten highly oxidized steroids with strong antibacterial activities were isolated from the Chinese soft coral Lobophytum sp., which could be developed as new chemotypes of antibacterial drug leads.
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- 2023
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8. Structurally Diverse Diterpenes from the South China Sea Soft Coral Sarcophyton trocheliophorum
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Yu-Ting Song, Dan-Dan Yu, Ming-Zhi Su, Hui Luo, Jian-Guo Cao, Lin-Fu Liang, Fan Yang, and Yue-Wei Guo
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soft coral ,Sarcophyton trocheliophorum ,capnosane ,cembrane ,absolute configuration ,anti-tumor activity ,Biology (General) ,QH301-705.5 - Abstract
The present investigation of the South China Sea soft coral Sarcophyton trocheliophorum resulted in the discovery of six new polyoxygenated diterpenes, namely sartrocheliols A–E (1, 3, 5–8) along with four known ones, 2, 4, 9, and 10. Based on extensive spectroscopic data analysis, sartrocheliol A (1) was identified as an uncommon capnosane diterpene, while sartrocheliols B–E (3, 5–8) were established as cembrane diterpenes. They displayed diverse structural features not only at the distinctly different carbon frameworks but also at the various types of heterocycles, including the epoxide, γ-lactone, furan, and pyran rings. Moreover, their absolute configurations were determined by a combination of quantum mechanical-nuclear magnetic resonance (QM-NMR) approach, modified Mosher’s method, and X-ray diffraction analysis. In the anti-tumor bioassay, compound 4 exhibited moderate cytotoxic activities against A549, H1975, MDA-MB-231, and H1299 cells with the IC50 values ranging from 26.3 to 47.9 μM.
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- 2023
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9. Cembrane Diterpenes Possessing Nonaromatic Oxacycles from the Hainan Soft Coral Sarcophyton mililatensis
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Ling Zhang, Min Yang, Zi-Hui Chen, Zeng-Yue Ge, Song-Wei Li, Xian-Yun Yan, Li-Gong Yao, Lin-Fu Liang, and Yue-Wei Guo
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soft coral ,Sarcophyton mililatensis ,cembrane diterpene ,absolute configuration ,TNF-α inhibitory ,binding mode ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Documents on the chemical composition of the soft coral Sarcophyton mililatensis are sparse. The present investigation of the Hainan soft coral S. mililatensis resulted in the discovery of six new cembrane diterpenes, sarcoxacyclols A–F (1–6) and four known analogs (7–10). Their structures were elucidated by extensive spectroscopic analysis along with a comparison with the data in current literature. The nonaromatic oxacycles in their structures were the rarely found tetrahydrofuran ether across C-1 and C-12 and tetrahydropyran ether across C-1 and C-11, respectively. Moreover, the absolute configuration of compound 4 was established unambiguously by X-ray diffraction analysis using Ga Kα radiation (λ = 1.34139 Å). Based on the biogenetical consideration, the absolute configurations of other five new compounds were tentatively assumed. Assessment of the bioactivity for these secondary metabolites revealed that compound 1 exhibited significant tumor necrosis factor (TNF)-α inhibitory activity (IC50 = 9.5 μmol/L), similar to the positive control dexamethasone (IC50 = 8.7 μmol/L), but no obvious cytotoxicity towards RAW264.7 cells (CC50 > 50 μmol/L). The preliminary molecular docking suggested the crucial roles of the hydroxyl and acetoxyl groups in the computational prediction of the binding mode between the diterpene and the protein.
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- 2023
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10. The Soft Coral Sarcophyton trocheliophorum: A Warehouse of Terpenoids with Structural and Pharmacological Diversity
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Qi-Bin Yang, Qihao Wu, Jun-Kun Chen, and Lin-Fu Liang
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soft coral ,Sarcophyton trocheliophorum ,terpenoids ,chemical structures ,pharmacological activities ,Biology (General) ,QH301-705.5 - Abstract
The soft coral Sarcophyton trocheliophorum, which was frequently encountered on Indo-Pacific and Red Sea coral reefs, furnished a wealth of secondary metabolites. Notably, terpenoids dominated the chemical profile of this species. In this review, we summarized the discovery of 156 terpenoids from the soft coral S. trocheliophorum specimens in different geographical areas. The structures comprised 13 terpenoidal classes with various functionalities. We covered the era from the first report of S. trocheliophorum-derived metabolites in 1976 up to October 2022. The biological effects of these chemical compositions on a vast array of potential pharmacological activities such as protein tyrosine phosphatase 1B (PTP1B) inhibitory, neuroprotective, cytotoxic, anti-inflammatory, antibacterial, antivirus, and immunomodulatory activities were also presented. This review also revealed an immense demand to explore the terpene biosynthetic gene clusters of this species besides the chemo- and bio-investigations.
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- 2022
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11. Uncommon Capnosane Diterpenes with Neuroprotective Potential from South China Sea Soft Coral Sarcophyton boettgeri
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Ye-Qing Du, Jing Chen, Meng-Jun Wu, Hai-Yan Zhang, Lin-Fu Liang, and Yue-Wei Guo
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soft coral ,Sarcophyton boettgeri ,capnosane ,absolute configuration ,neuroprotective effect ,Biology (General) ,QH301-705.5 - Abstract
The first investigation of the South China Sea soft coral Sarcophyton boettgeri afforded five new capnosane diterpenes, sarboettgerins A–E (1–5), together with one known related compound, pavidolide D (6). Their structures, including absolute configurations, were elucidated by the extensive spectroscopic analysis, 13C NMR calculations, and X-ray diffraction. Among them, new compounds 1–5 were featured by the rarely encountered Z-geometry double bond Δ1 within the 5/11-fused bicyclic capnosane carbon framework. Plausible biogenetic relationships of all isolates were proposed, and they might give an insight into future biomimetic synthesis of these novel compounds. In an in vitro bioassay, compound 5 displayed potent anti-neuroinflammatory activity against LPS-induced NO release in BV-2 microglial cells, which might be developed as a new type of potential neuroprotective agent in future.
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- 2022
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12. Mililatensols A–C, New Records of Sarsolenane and Capnosane Diterpenes from Soft Coral Sarcophyton mililatensis
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Qing Bu, Min Yang, Xian-Yun Yan, Song-Wei Li, Zeng-Yue Ge, Ling Zhang, Li-Gong Yao, Yue-Wei Guo, and Lin-Fu Liang
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soft coral ,Sarcophyton mililatensis ,sarsolenane ,capnosane ,stereochemistry ,anti-inflammatory activity ,Biology (General) ,QH301-705.5 - Abstract
Three unusual diterpenes with rare sarsolenane and capnosane skeletons, namely mililatensols A–C (1–3), were isolated from the South China Sea soft coral Sarcophyton mililatensis, leading to the first record of sarsolenane and capnosane diterpenes from the title animal. The structures of compounds 1–3 were established by extensive spectroscopic analysis and comparison with the literature data. Moreover, the absolute configuration of 2 was determined by TDDFT ECD calculations. In an in vitro bioassay, none of the isolated compounds showed obvious anti-inflammatory activity on LPS-induced TNF-α release in RAW264.7 macrophages. In the preliminary virtual screening of inhibitory potential against SARS-CoV-2 by molecular docking, the results showed these three diterpenes were potential SARS-CoV-2 Mpro inhibitors.
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- 2022
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13. Structurally Diverse Metabolites from the Ophiorrhiza japonica Bl. and Their Antioxidant Activities In Vitro and PPARα Agonistic Activities In Silico
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Qing Bu, Yang Jin, Meng-Juan Xu, Lei Wu, and Lin-Fu Liang
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Ophiorrhiza japonica ,ophiorrhizaquinone A ,alkaloid ,antioxidant ,molecular docking ,Organic chemistry ,QD241-441 - Abstract
Ophiorrhiza japonica Bl. is a traditional Chinese materia medica widely used to treat several diseases. Chemical and pharmacological studies on O. japonica have been carried out; however, neither of them has been fully explored. In this study, an array of compounds was isolated from the title plant, including a new anthraquinone, ophiorrhizaquinone A (1), three alkaloids 2–4 and seven other compounds 5–11 with diverse structural types. Additionally, compounds 2, 5, 7, 8, 10 and 11 were isolated from the genus of Ophiorrhiza for the first time. Antioxidant bioassays in vitro using DPPH and ABTS were performed, and the results showed that compound 3 exhibited modest antioxidant activity with IC50 values of 0.0321 mg/mL and 0.0319 mg/mL, respectively. An in silico study of PPARα agonistic activities of compounds 2 and 3 was conducted by molecular docking experiments, revealing that both of them occupied the active site of PPARα via hydrogen bonds and hydrophobic interactions effectively. This study enriched both the phytochemical and pharmacological profiles of O. japonica.
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- 2022
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14. Secondary Metabolites from Marine Sponges of the Genus Oceanapia: Chemistry and Biological Activities
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Meng-Juan Xu, Lin-Jing Zhong, Jun-Kun Chen, Qing Bu, and Lin-Fu Liang
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Oceanapia ,sponge ,secondary metabolites ,biological activities ,Biology (General) ,QH301-705.5 - Abstract
In this review, we summarized the distribution of the chemically investigated Oceanapia sponges, including the isolation and biological activities of their secondary metabolites, covering the literature from the first report in 1989 to July 2019. There have been 110 compounds reported during this period, including 59 alkaloids, 33 lipids, 14 sterols and 4 miscellaneous compounds. Besides their unique structures, they exhibited promising bioactivities ranging from insecticidal to antibacterial. Their complex structural characteristics and diverse biological properties have attracted a great deal of attention from chemists and pharmaceuticals seeking to perform their applications in the treatment of disease.
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- 2022
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15. New flexible cembrane-type macrocyclic diterpenes as TNF-α inhibitors from the South China Sea soft coral Sarcophyton mililatensis
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Qing Bu, Min Yang, Xian-Yun Yan, Li-Gong Yao, Yue-Wei Guo, and Lin-Fu Liang
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China ,Molecular Structure ,Tumor Necrosis Factor-alpha ,Structural Biology ,Animals ,Tumor Necrosis Factor Inhibitors ,Prospective Studies ,General Medicine ,Diterpenes ,Anthozoa ,Molecular Biology ,Biochemistry - Abstract
A further study on the rarely reported soft coral Sarcophyton mililatensis disclosed five new flexible cembrane-type macrocyclic diterpenes sarcomililatols C-G (1-5) and two known analogues 6 and 7. The structures and absolute configurations of natural macrocyclic compounds 1-6 were established by the extensive spectroscopic analysis, X-ray diffraction analysis, time-dependent density functional theory/electronic circular dichroism (TDDFT ECD) calculations, chemical reaction, and modified Mosher's method. In the bioassays, the macrocyclic diterpene 2 exhibited potent TNF-α inhibition (IC
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- 2022
16. Oxygenated Cembrane Diterpenes from the South China Sea Soft Coral Sinularia tumulosa
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Sheng-Hui Zhu, Dan-Dan Yu, Ming-Zhi Su, Hui Luo, Li-Gong Yao, Feifei Gu, Lin-Fu Liang, Hong Wang, and Yue-Wei Guo
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Molecular Medicine ,Bioengineering ,General Chemistry ,General Medicine ,Molecular Biology ,Biochemistry - Published
- 2023
17. Antitumor Cembrane Diterpenoids from the South China Sea Soft Coral Lobophytum sp
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Yu‐Ting Song, Dan‐Dan Yu, Ming Zhi Su, Hui Luo, Jian‐Guo Cao, Li‐Gong Yao, Lin‐Fu Liang, Yue‐Wei Guo, and Fan Yang
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Molecular Medicine ,Bioengineering ,General Chemistry ,General Medicine ,Molecular Biology ,Biochemistry - Published
- 2023
18. Cladiella Octocorals: Enormous Sources of Secondary Metabolites with Diverse Structural and Biological Properties
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Ye‐Qing Du, Lin‐Fu Liang, and Yue‐Wei Guo
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Molecular Medicine ,Bioengineering ,General Chemistry ,General Medicine ,Molecular Biology ,Biochemistry - Abstract
Marine octocorals belonging to the genus Cladiella, usually encountered on reefs in the Indo-Pacific region, have been proven to be rich sources of diverse secondary metabolites with intriguing structural features and promising bioactivities. In this review, 155 compounds from six unambiguously identified C. krempfi, C. australis, C. pachyclados, C. hirsuta, C. tuberculosa, C. conifera, together with several unidentified Cladiella spp. are summarized covering the literatures from 2006 to August 2022. It is noteworthy that diterpenoids dominated the secondary metabolite profile of this genus counting for 78 %. Structurally, the majority of these diterpenes belonged to eunicellan family characterized by different patterns of ether linkage. The impacts of these chemical compositions on an array of potential pharmacological activities were also reviewed, giving an overview of the potential application of Cladiella secondary metabolites.
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- 2022
19. Review for 'Notes on the distribution, ecology and open sea mariculture trials of the Philippine blue sponge, Xestospongia sp. (Porifera)'
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Lin-Fu Liang
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- 2022
20. Enzymatic Synthesis of Variediene Analogs
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Lin‐Fu Liang and Jeroen S. Dickschat
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Hemiterpenes ,Organophosphorus Compounds ,Terpenes ,Organic Chemistry ,Fungi ,General Chemistry ,Catalysis - Abstract
Five analogs of dimethylallyl diphosphate (DMAPP) with additional or shifted Me groups were converted with isopentenyl diphosphate (IPP) and the fungal variediene synthase from Aspergillus brasiliensis (AbVS). These enzymatic reactions resulted in the formation of several new terpene analogs that were isolated and structurally characterised by NMR spectroscopy. Several DMAPP analogs showed a changed reactivity giving access to compounds with unusual skeletons. Their formation is mechanistically rationalised and the absolute configurations of all obtained compounds were determined through a stereoselective deuteration strategy, revealing absolute configurations that are analogous to that of the natural enzyme product variediene.
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- 2022
21. Secondary Metabolites from Marine Sponges of the Genus
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Meng-Juan, Xu, Lin-Jing, Zhong, Jun-Kun, Chen, Qing, Bu, and Lin-Fu, Liang
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Biological Products ,Insecticides ,Sterols ,Alkaloids ,Animals ,Humans ,Secondary Metabolism ,Lipids ,Anti-Bacterial Agents ,Porifera - Abstract
In this review, we summarized the distribution of the chemically investigated
- Published
- 2021
22. Rare Cembranoids from Chinese Soft Coral Sarcophyton ehrenbergi: Structural and Stereochemical Studies
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Quan Zhang, Wei Tang, Yue-Wei Guo, Yu-Cheng Gu, Heng Li, Min Yang, Geng Li, and Lin-Fu Liang
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Models, Molecular ,Circular dichroism ,Chemical research ,010405 organic chemistry ,Chemistry ,Stereochemistry ,Coral ,Organic Chemistry ,Molecular Conformation ,Positive control ,Sarcophyton ehrenbergi ,Time-dependent density functional theory ,Anthozoa ,010402 general chemistry ,01 natural sciences ,0104 chemical sciences ,chemistry.chemical_compound ,Animals ,Moiety ,Diterpenes ,Diterpene - Abstract
A detailed chemical research of soft coral Sarcophyton ehrenbergi from the South China Sea yielded five new cembranoids 1-5 featuring an α,β-unsaturated-γ-lactone moiety rarely at C-6 to C-19, along with one known related diterpene 6. The structures and absolute configurations of 1-5 were established in the light of extensive spectroscopic data analysis, chemical reaction, X-ray diffraction analysis, TDDFT/ECD (time-dependent density functional theory/electronic circular dichroism) calculations, and biosynthesis path. This study led to the stereostructural revision of 6, which was misassigned by erroneously applying the empirical ECD helicity rule, indicating a challenging and risky work to determine the structure of this type of marine cembranoids. In the TNF-α inhibitory biotest, compound 2 exhibited a potent inhibitory activity (IC50 = 8.5 μM), which was analogous to the positive control dexamethasone (IC50 = 8.7 μM).
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- 2019
23. Uncommon Polyoxygenated Sesquiterpenoids from South China Sea Soft Coral Lemnalia flava
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Hong Wang, Han Sun, Yue-Wei Guo, Xiao-Lu Li, Jiadong Sun, Lin-Fu Liang, Qihao Wu, and Fei Ye
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Models, Molecular ,China ,South china ,Bicyclic molecule ,Chemistry ,Stereochemistry ,Coral ,Organic Chemistry ,Molecular Conformation ,Carbon-13 NMR ,Anthozoa ,Crystallography, X-Ray ,Molecular conformation ,Residual dipolar coupling ,Animals ,Sesquiterpenes ,Density Functional Theory - Abstract
A detailed chemical investigation of the Chinese soft coral Lemnalia flava yielded four new nardosinane-type sesquiterpenoids (1–4), one new neolemnane-type sesquiterpenoid (5), and one new sesquiterpenoid with an uncommon 6/9 fused bicyclic skeleton (6), together with two known related compounds (7 and 8). The structures and absolute configurations of 1–8 were determined on the basis of extensive spectroscopic data analyses, X-ray diffraction analysis, chemical reactions, and computer-assisted structural elucidation including 13C NMR data calculation, residual dipolar coupling based NMR analysis, and time-dependent density functional theoryelectronic circular dichroism calculation. Plausible biogenetic pathways of two uncommon sesquiterpenoids (4 and 6) were proposed.
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- 2019
24. A new 5α,8α-epidioxysterol with immunosuppressive activity from the South China Sea soft coral Sinularia sp
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Yue-Wei Guo, Heng Li, Wei Tang, Lin-Fu Liang, and Min Yang
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South china ,biology ,010405 organic chemistry ,Chemistry ,Lymphocyte ,Coral ,Organic Chemistry ,Epidioxysterol ,Plant Science ,biology.organism_classification ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,Analytical Chemistry ,Microbiology ,010404 medicinal & biomolecular chemistry ,medicine.anatomical_structure ,Ic50 values ,medicine ,Bioassay ,Sinularia ,Cytotoxicity - Abstract
A new 5α,8α-epidioxysterol, namely yalongsterol A (1), along with two known related steroids 5α,8α-epidioxy-24-methyl-cholesta-6,24(28)-dien-3β-ol (2) and (22E,24S)-5α,8α-epidioxy-24-methyl-cholesta-6,22-dien-3β-ol (3), were isolated from the South China Sea soft coral Sinularia sp. Their structures were established by extensive spectroscopic analyses and comparisons of the spectral data with those reported in the literature. In bioassay, compounds 1-3 showed moderate immunosuppressive activities against T and/or B lymphocyte cells with IC50 values ranging from 19.30 to 59.49 μM, and low cytotoxicity on murine splenocytes with CC50 values ranging from 40.88 to 62.29 μM.[Formula: see text].
- Published
- 2019
25. A new brominated polyacetylene from Chinese marine sponge Xestospongia testudinaria
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Yue-Wei Guo, Min Yang, Hai-Li Liu, Li-Gong Yao, and Lin-Fu Liang
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China ,Stereochemistry ,Pharmaceutical Science ,Polyenes ,01 natural sciences ,Analytical Chemistry ,Xestospongia testudinaria ,Polyacetylene ,chemistry.chemical_compound ,Drug Discovery ,Animals ,Pharmacology ,Molecular Structure ,biology ,010405 organic chemistry ,Chemistry ,Organic Chemistry ,Polyynes ,General Medicine ,biology.organism_classification ,Hydrocarbons, Brominated ,Porifera ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,Sponge ,Complementary and alternative medicine ,Molecular Medicine - Abstract
A new brominated polyacetylene xestonariene J (1), bearing a rare 2,4-dibromo-1-ene-3-yne terminal in the molecule, along with two known related analogues (2 and 3), was obtained from Chinese marine sponge Xestospongia testudinaria. Its structure was determined on the basis of detailed spectroscopic analysis and comparison with literature data.
- Published
- 2019
26. Further polyoxygenated cembranoids from South China Sea soft coral Sarcophyton ehrenbergi
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Heng Li, Geng Li, Li-Gong Yao, Yue-Wei Guo, Wei Tang, and Lin-Fu Liang
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South china ,Stereochemistry ,Coral ,Positive control ,01 natural sciences ,Biochemistry ,Mice ,Structure-Activity Relationship ,Drug Discovery ,Cembrane Diterpenes ,Animals ,Seawater ,Molecular Biology ,010405 organic chemistry ,Chemistry ,Tumor Necrosis Factor-alpha ,Spectrum Analysis ,Organic Chemistry ,Absolute configuration ,Sarcophyton ehrenbergi ,Anthozoa ,0104 chemical sciences ,Oxygen ,010404 medicinal & biomolecular chemistry ,RAW 264.7 Cells ,Diterpenes - Abstract
Eleven new cembrane diterpenes, namely, sarcoehrenins A-J (1-9, 11) and (2S,11S,12S)-isosarcophytoxide (10), along with six known compounds, gibberosene B (12), (13S)-cembra-1,3,7,11-tetraen-13-ol (13), (+)-sarcophtol (14), cembrene-C (15), (1R,4R,2E,7E,11E)-cembra-2,7,11-trien-4-ol (16) and (1S,4R,2E,7E,11E)-cembratrien-4-ol (17) were isolated from the soft coral Sarcophyton ehrenbergi collected from Weizhou Island, Beibu Gulf, South China Sea. The structures of these compounds were elucidated by a combination of detailed spectroscopic analyses, chemical methods, and comparison with reported data. The absolute configuration of compound 2 was established by the modified Mosher's method in association with TDDFT ECD calculation, while the absolute configuration of compound 3 was assigned by TDDFT ECD approach. In in vitro bioassays, compounds 13 and 17 showed potent TNF-α inhibitory activities being similar to that of positive control dexamethasone. A preliminary structural-activity relationship was also described.
- Published
- 2020
27. One uncommon bis-sesquiterpenoid from Xisha soft coral Litophyton nigrum
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Fan Yang, Qiang Hua, Li-Gong Yao, Lin-Fu Liang, Yu-Xia Lou, Yan-Hua Lu, Fa-Liang An, and Yue-Wei Guo
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Organic Chemistry ,Drug Discovery ,Biochemistry - Published
- 2022
28. Uncommon nornardosinane, seconeolemnane and related sesquiterpenoids from Xisha soft coral Litophyton nigrum
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Lin-Fu Liang, Jun Zhang, Fan Yang, Yan-Hua Lu, Song-Wei Li, and Yue-Wei Guo
- Subjects
Litophyton ,Models, Molecular ,010405 organic chemistry ,Chemistry ,Stereochemistry ,Coral ,Organic Chemistry ,Absolute configuration ,Antineoplastic Agents ,Anthozoa ,Crystallography, X-Ray ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,Cell Line, Tumor ,Neoplasms ,Drug Discovery ,Animals ,Humans ,Molecular Biology ,Sesquiterpenes ,Human cancer ,Cell Proliferation - Abstract
Three new nardosinane-type sesquiterpenoids linardosinenes A-C (1-3) and four new neolemnane-type sesquiterpenoids lineolemnenes A-D (4-7), together with the related known compound 4-acetoxy-2,8-neolemnadien-5-one (8), were isolated from the Xisha soft coral Litophyton nigrum. The structures of these new compounds were elucidated by comprehensive analyses of spectroscopic data, in association withmodified Mosher's method and ECD calculations for configurational assignments and the absolute configuration of8was determined by X-ray diffraction analysis for the first time. Structurally uncommon nornardosinane and seconeolemnane skeletons for compounds 1 and 7, respectively, are rare carbon frameworks in naturally occurring sesquiterpenoids. The absolute configurations of 1, 7, and 8 were determined by modified Mosher's method, TDDFT ECD approach, and X-ray diffraction analysis, respectively. This is the first chemical study of L. nigrum and the first report of nornardosinane, seconeolemnane and related sesquiterpenoids from the genus Litophyton. The isolates 1-7 were evaluated for their cytotoxicity against THP-1, SNU-398, HT-29, Capan-1 and A549 cell lines and inhibitory activities against PTP1B, BRD4, HDAC1 and HDAC6 protein kinases. The results indicated that compounds 2-5 inhibited proliferation of human cancer cells. However, none of them were potent inhibitors of protein kinases.
- Published
- 2019
29. Spongian diterpenes from Chinese marine sponge Spongia officinalis
- Author
-
Li-Gong Yao, Kai-Xian Chen, Guan-Ying Han, Dong-Yu Sun, Yue-Wei Guo, and Lin-Fu Liang
- Subjects
China ,South china ,Stereochemistry ,Carbon skeleton ,010402 general chemistry ,Ring (chemistry) ,01 natural sciences ,chemistry.chemical_compound ,4-Butyrolactone ,Furan ,Drug Discovery ,Animals ,Furans ,Spongia officinalis ,Pharmacology ,Molecular Structure ,biology ,010405 organic chemistry ,Absolute configuration ,General Medicine ,biology.organism_classification ,Porifera ,0104 chemical sciences ,Sponge ,chemistry ,Diterpenes ,Diterpene - Abstract
3-Nor-spongiolide A (1), belonging to the extremely rare 3-nor-spongian carbon skeleton, and spongiolides A (2) and B (3), having γ-butenolide instead of furan ring as usual for ring D, together with six related known metabolites were isolated from South China Sea sponge Spongia officinalis as its metabolic components. Their structures were elucidated on the basis of extensive spectroscopic analysis. The absolute configurations of three new compounds 1–3 were determined by ECD calculations.
- Published
- 2018
30. Structural, stereochemical, and bioactive studies of cembranoids from Chinese soft coral Sarcophyton trocheliophorum
- Author
-
Li Gong Yao, Tibor Kurtán, Jia Li, Yue-Wei Guo, Le Fu Lan, Attila Mándi, and Lin Fu Liang
- Subjects
010405 organic chemistry ,Chemistry ,Stereochemistry ,Coral ,Organic Chemistry ,Absolute configuration ,Time-dependent density functional theory ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Nmr data ,0104 chemical sciences ,chemistry.chemical_compound ,Természettudományok ,Drug Discovery ,Sarcophyton trocheliophorum ,Moiety ,Specific rotation ,Kémiai tudományok ,Antibacterial activity - Abstract
A series of highly oxidative new cembranoids with diverse structural features such as a dienoate moiety (sarcophytonolides S – U, 1–3) or an α,β-unsaturated e-lactone (sartrolides H – J, 4–6) were obtained from Hainan soft coral Sarcophyton trocheliophorum, along with known related analogues 7–13. It is an extremely challenging work to determine the absolute configurations of these metabolites. For compounds 1, 3 and 4, solution TDDFT calculation of ECD and specific rotation were applied in combination with conformational analysis and NMR data to determine their relative and absolute configurations, leading to the revision of relative configuration of 14. The absolute configurations of compounds 8–10 were determined by the solid-state TDDFT-ECD approach, and that of 8 was further confirmed by single-crystal X-ray diffraction experiment with Cu Kα radiation. In the bioassays, compound 8 exhibited not only moderate protein tyrosine phosphatase 1B (PTP1B) inhibitory activity (IC50 = 15.4 μM) but also moderate antibacterial activity against Staphylococcus aureus Newman strain (MIC50 = 250 μM).
- Published
- 2018
31. Serratanes from Whole Plant of Palhinhaea cernua
- Author
-
Xiang-Nen Song, Lin-Fu Liang, Qiu-Han Chen, Ting Liu, Hong Chen, Hong-Yang Chen, and Jiang-Hao Xu
- Subjects
Chemistry ,Botany ,Plant Science ,General Chemistry ,General Biochemistry, Genetics and Molecular Biology - Published
- 2019
32. A Novel Sarsolenane Diterpene as a PTP1B Inhibitor from Hainan Soft Coral Sarcophyton trocheliophorum Marenzeller
- Author
-
Jia Li, Xiaoxuan Shi, Yue-Wei Guo, Yinghua Zhu, He-Yao Wang, Jinan Wang, Weiliang Zhu, and Lin-Fu Liang
- Subjects
chemistry.chemical_classification ,South china ,010405 organic chemistry ,Chemistry ,Stereochemistry ,Metabolite ,Coral ,General Chemistry ,010402 general chemistry ,01 natural sciences ,Protein Tyrosine Phosphatase 1B ,0104 chemical sciences ,chemistry.chemical_compound ,Enzyme ,Sarcophyton trocheliophorum ,Diterpene ,IC50 - Abstract
A novel sarsolenane diterpene, named secodihydrosarsolenone (1), as a minor component was obtained from the South China Sea soft coral Sarcophyton trocheliophorum Marenzeller. Its structure was elucidated by detailed spectroscopic analysis. Compound 1 exhibited moderate inhibitory activity (IC50=13.7 µmol•L−1) against protein tyrosine phosphatase 1B (PTP1B), a key target for the treatment of type 2 diabetes, representing the first report of PTP1B inhibitory activity for sarsolenane diterpenes. This discovery promotes computational prediction of binding mode between the enzyme and the metabolite, suggesting a crucial role of the residues Tyr46, Ser216 and Arg221 in the binding action.
- Published
- 2017
33. A new 5α,8α-epidioxysterol with immunosuppressive activity from the South China Sea soft coral
- Author
-
Min, Yang, Lin-Fu, Liang, Heng, Li, Wei, Tang, and Yue-Wei, Guo
- Subjects
B-Lymphocytes ,China ,Mice ,Molecular Structure ,Spectrum Analysis ,T-Lymphocytes ,Animals ,Humans ,Steroids ,Cholesterol Esters ,Anthozoa ,Immunosuppressive Agents ,Spleen - Abstract
A new 5α,8α-epidioxysterol, namely yalongsterol A (
- Published
- 2019
34. Further New Highly Oxidative Cembranoids from the Hainan Soft Coral Sarcophyton trocheliophorum
- Author
-
Xu-Wen Li, Lin-Fu Liang, Wei Xiao, Yue-Wei Guo, and Wen-Ting Chen
- Subjects
Soft coral ,Pharmacology ,South china ,010405 organic chemistry ,Structure elucidation ,Coral ,Organic Chemistry ,Pharmacology toxicology ,Cembranoids ,Sarcophytrol ,Plant Science ,Biology ,010402 general chemistry ,Toxicology ,01 natural sciences ,Biochemistry ,Sarcophyton trocheliophorum ,0104 chemical sciences ,Analytical Chemistry ,Plant biochemistry ,Botany ,Original Article ,14. Life underwater ,Food Science - Abstract
Three new highly oxidative cembranoids, sarcophytrols D–F (1–3), were obtained from the South China Sea soft coral Sarcophyton trocheliophorum, along with two known related ones (4 and 5). Their structures were elucidated by extensive spectroscopic analyses and by comparison with literature data. The discovery of these new secondary metabolites enriched the family of cembranoids deduced from the title animal. Graphical Abstract
- Published
- 2016
35. Polycyclic furanobutenolide-derived norditerpenoids from the South China Sea soft corals Sinularia scabra and Sinularia polydactyla with immunosuppressive activity
- Author
-
Lin-Fu Liang, Li-Gong Yao, Heng Li, Chun-hua Wang, Yue-Wei Guo, Min Yang, Wei Tang, Wan-Xiang Cui, Song-Wei Li, and Geng Li
- Subjects
Circular dichroism ,South china ,Stereochemistry ,Crystallography, X-Ray ,01 natural sciences ,Biochemistry ,Norditerpenoids ,Sinularia polydactyla ,Lactones ,Species Specificity ,Drug Discovery ,Animals ,Bioassay ,Sinularia ,Furans ,Nuclear Magnetic Resonance, Biomolecular ,Molecular Biology ,Cells, Cultured ,biology ,010405 organic chemistry ,Chemistry ,Organic Chemistry ,Absolute configuration ,Anthozoa ,biology.organism_classification ,Sinularia scabra ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,Diterpenes ,Immunosuppressive Agents - Abstract
One new polycyclic furanobutenolide-derived norcembranoid, xiguscabrolide H (1), together with eleven known related norditerpenoids 2-12 were isolated from South China Sea soft corals Sinularia scabra and S. polydactyla, respectively. Among them, compounds 1, 6, 8, and 12 were discovered from the former species, while compounds 2-5, 7, and 9-11 were obtained from the latter species. The structure of new compound 1 was elucidated by extensive spectroscopic analysis and by the comparison with the reported data. With the assistance of time-dependent density functional theory electronic circular dichroism (TDDFT-ECD) calculations, its absolute configuration was determined. Moreover, the absolute stereostructures of the known compounds 3, 4, and 9-12, of which only relative configurations were assigned, were established for the first time by X-Ray diffraction analysis and TDDFT-ECD calculations, respectively. In bioassay, several isolates exhibited potent inhibitory effects on the ConA-induced T lymphocytes and/or LPS-induced B lymphocytes proliferation.
- Published
- 2020
36. Cytotoxic polyhydroxylated steroids from the South China Sea soft coral Lobophytum sp
- Author
-
Ze-Hong Miao, Quan Zhang, Yue-Wei Guo, Bin Wu, and Lin-Fu Liang
- Subjects
China ,South china ,food.ingredient ,Coral ,Oceans and Seas ,Clinical Biochemistry ,Molecular Conformation ,030209 endocrinology & metabolism ,Antineoplastic Agents ,Biochemistry ,Lobophytum ,03 medical and health sciences ,Structure-Activity Relationship ,0302 clinical medicine ,Endocrinology ,food ,Cell Line, Tumor ,Cytotoxic T cell ,Bioassay ,Animals ,Humans ,Molecular Biology ,Cell Proliferation ,Pharmacology ,Traditional medicine ,Dose-Response Relationship, Drug ,Chemistry ,Organic Chemistry ,Anthozoa ,030220 oncology & carcinogenesis ,Drug Screening Assays, Antitumor - Abstract
Four new polyhydroxylated steroids lobophysterols A-D (1-4), together with two known related compounds sarcophytosterol (5) and klyflaccisteroid B (6), were isolated from the South China Sea soft coral Lobophytum sp. Their structures were elucidated on the basis of spectroscopic analysis and by comparison with those reported in the literature. In bioassay, compound 4 showed weak cytotoxicities against HT-29, SNU-398, and Capan-1 cells.
- Published
- 2018
37. New Bicyclic Cembranoids from the South China Sea Soft Coral Sarcophyton trocheliophorum
- Author
-
Yue-Wei Guo, Wen-Ting Chen, Xu-Wen Li, He-Yao Wang, and Lin-Fu Liang
- Subjects
Multidisciplinary ,South china ,Bicyclic molecule ,Molecular Structure ,010405 organic chemistry ,Stereochemistry ,Coral ,010402 general chemistry ,Anthozoa ,01 natural sciences ,Article ,0104 chemical sciences ,chemistry.chemical_compound ,Oxepane ,chemistry ,Pyran ,Furan ,Chemical conversion ,Sarcophyton trocheliophorum ,Animals ,Diterpenes - Abstract
Nine new bicyclic cembranoids, sarcophytrols M–U(1–9), were isolated from the South China Sea soft coral Sarcophyton trocheliophorum as minor components, along with one known related cembranoid 10. Their structures were elucidated by detailed spectroscopic analysis and chemical conversion. The chemical structures of these metabolites are characterized by the different patterns of the additional cyclization within the 14-member skeleton, which leading to the formation of furan, pyran, oxepane, and peroxyl rings, respectively. Among them, sarcophytrols R and S(6 and 7) share a rare decaryiol skeleton with an unusual C12/C15 cyclization. In addition, the absolute configurations of sarcophytrols M and T(1 and 8) were determined by the modified Mosher’s method. The research of these new secondary metabolites provided a further understanding of the diversity of cyclized cembranoids from the title species.
- Published
- 2017
38. Further brominated polyacetylenes with pancreatic lipase inhibitory activity from Chinese marine sponge Xestospongia testudinaria
- Author
-
Hai-Li Liu, Yue-Wei Guo, Min Yang, Lin-Fu Liang, Ting Wang, and He-Yao Wang
- Subjects
Stereochemistry ,Pharmaceutical Science ,Positive control ,Marine Biology ,Inhibitory postsynaptic potential ,01 natural sciences ,Xestonariene I ,Analytical Chemistry ,Xestospongia testudinaria ,Drug Discovery ,Pancreatic lipase ,Animals ,IC50 ,Nuclear Magnetic Resonance, Biomolecular ,Pancreas ,Pharmacology ,biology ,Molecular Structure ,010405 organic chemistry ,Organic Chemistry ,Polyynes ,General Medicine ,Lipase ,biology.organism_classification ,0104 chemical sciences ,Hydrocarbons, Brominated ,Xestospongia ,010404 medicinal & biomolecular chemistry ,Sponge ,Complementary and alternative medicine ,Biochemistry ,biology.protein ,Molecular Medicine - Abstract
A new brominated polyacetylene, xestonariene I (1), along with three known related analogues (2–4), was obtained from Chinese marine sponge Xestospongia testudinaria. Its structure was determined on the basis of detailed spectroscopic analysis and by comparison with literature data. Compound 4 exhibited significant inhibitory activity against pancreatic lipase, which plays a key role in preventing obesity, with an IC50 value of 0.61 μM, being comparable to that of the positive control orlistat (IC50 = 0.78 μM).
- Published
- 2017
39. Sarcophytrols G - L, Novel Minor Metabolic Components from South China Sea Soft Coral Sarcophyton trocheliophorum Marenzeller
- Author
-
Li-Gong Yao, He-Yao Wang, Ernesto Mollo, Lin-Fu Liang, Yue-Wei Guo, Wei Xiao, and Wen-Ting Chen
- Subjects
China ,South china ,Coral ,Terpenoids ,Zoology ,Bioengineering ,Antineoplastic Agents ,Biology ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Sarcophyton trocheliophorum ,Anthozoa ,Animals ,Molecular Biology ,Soft coral ,Protein Tyrosine Phosphatase, Non-Receptor Type 1 ,Molecular Structure ,010405 organic chemistry ,Ecology ,Structure elucidation ,Spectrum Analysis ,General Chemistry ,General Medicine ,Marine invertebrates ,biology.organism_classification ,Protein Tyrosine Phosphatase 1B ,Terpenoid ,0104 chemical sciences ,Molecular Medicine ,PTP1B inhibitory activities ,Spectrum analysis ,Diterpenes - Abstract
Minor metabolic components, six new cembranoids sarcophytrols G – L (1 – 6) along with two known related analogues 7 and 8, were isolated from the South China Sea soft coral Sarcophyton trocheliophorum. Their structures were elucidated by extensive spectroscopic analyses (1D- and 2D-NMR, and ESI-MS.) as well as comparison with literature data. As part of our ongoing research project for discovering bioactive substances from Chinese marine invertebrates, compounds 1 – 8 were tested for their inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), a key target for the treatment of Type-II diabetes and obesity. However, none of them exhibited potent PTP1B inhibitory activities. This article is protected by copyright. All rights reserved.
- Published
- 2017
40. Sarsolenane and Capnosane Diterpenes from the Hainan Soft CoralSarcophyton trocheliophorumMarenzeller as PTP1B Inhibitors
- Author
-
Jia Li, Wen Zhang, Li-Xin Gao, Yue-Wei Guo, Attila Mándi, Lin Fu Liang, and Tibor Kurtán
- Subjects
Chemistry ,Stereochemistry ,Coral ,Organic Chemistry ,Absolute configuration ,Sarcophyton trocheliophorum ,Physical and Theoretical Chemistry ,Related derivatives ,Terpenoid - Abstract
Two new sarsolenane diterpenes, dihydrosarsolenone (2), methyl dihydrosarsolenoneate (3), and two new capnosane diterpenes, sarsolilides B (5) and C (6), were isolated together with the known analogue, sarsolilide A (4), from the Hainan soft coral Sarcophyton trocheliophorum Marenzeller. Their structures were elucidated by detailed spectroscopic analysis and by comparison with reported data, leading to a structure revision of sarsolenone (1). The absolute configurations of 2 and 5 were determined by TDDFT ECD calculations, and they could be used as ECD reference compounds in the determination of the absolute configuration of their related derivatives. Compounds 4 and 5 exhibited inhibitory activity in vitro against protein tyrosine phosphatases 1B (PTP1B), representing the first report of PTP1B inhibitory activity for capnosane diterpenes.
- Published
- 2014
41. Preliminary Study of Terpenes from the Leaves of Cyclocarya paliurus
- Author
-
Yue-Yang Fan, Kun Li, Lin-Fu Liang, Kai-Yu Huang, and Shan-Nan Du
- Subjects
biology ,010405 organic chemistry ,Chemistry ,Plant Science ,General Chemistry ,biology.organism_classification ,01 natural sciences ,General Biochemistry, Genetics and Molecular Biology ,0104 chemical sciences ,Terpene ,010404 medicinal & biomolecular chemistry ,Paliurus ,Botany ,Cyclocarya - Published
- 2018
42. Terpenes from the Soft Corals of the GenusSarcophyton:Chemistry and Biological Activities
- Author
-
Lin-Fu Liang and Yue-Wei Guo
- Subjects
Flavonoids ,biology ,Cell Survival ,Terpenes ,Sarcophyton ,Chemistry ,Fungi ,Structural diversity ,Bioengineering ,General Chemistry ,General Medicine ,Anthozoa ,biology.organism_classification ,Biochemistry ,Terpene ,Genus ,Botany ,Sarcophyton trocheliophorum ,Animals ,Humans ,Molecular Medicine ,Diterpenes ,Sesquiterpenes ,Molecular Biology - Abstract
This review covers structural diversity and biological activities of terpenes from soft corals of the genus of Sarcophyton, reported from 1995 to July, 2011. During this period, besides undefined species, 16 species of the genus Sarcophyton, from different geographical areas, had been chemically examined. Two hundred and five terpenes had been isolated from this genus, including eleven sesquiterpenes, 165 diterpenes, 29 biscembranoids, some of which had novel skeletons. They exhibited various biological features, such as antifeedant, anti-inflammatory, antiviral, and antifouling activities.
- Published
- 2013
43. Cembrane diterpenoids from the soft coral Sarcophyton trocheliophorum Marenzeller as a new class of PTP1B inhibitors
- Author
-
Orazio Taglialatela-Scafati, Lin-Fu Liang, Li-Xin Gao, Yue-Wei Guo, Jia Li, Liang, L. F., Gao, L. X., Li, J., Guo, Y, and TAGLIALATELA SCAFATI, Orazio
- Subjects
Protein Tyrosine Phosphatase, Non-Receptor Type 1 ,Magnetic Resonance Spectroscopy ,South china ,Bicyclic molecule ,Stereochemistry ,Chemistry ,Coral ,Organic Chemistry ,Clinical Biochemistry ,Molecular Conformation ,Pharmaceutical Science ,Anthozoa ,Biochemistry ,Protein Tyrosine Phosphatase 1B ,Terpene ,Structure-Activity Relationship ,Drug Discovery ,Sarcophyton trocheliophorum ,Animals ,Humans ,Molecular Medicine ,Diterpenes ,Enzyme Inhibitors ,Molecular Biology ,Protein Binding - Abstract
A detailed investigation of the South China Sea soft coral Sarcophyton trocheliophorum Marenzeller yielded, along with six known terpenes (6-11), the new sarcophytonolides N-R (1-5), whose structures have been elucidated by detailed spectroscopic analysis. Sarcophytonolides N-R are mono- or bicyclic cembranoids characterized by the presence of three/four double bonds and oxidized methyl groups. Some of the isolated compounds showed significant inhibitory activity against human protein tyrosine phosphatase 1B (PTP1B) enzyme, a key target for the treatment of type-II diabetes and obesity, and some preliminary structure-activity relationships have been drawn. This is the first report on the anti-PTP1B activity of cembrane diterpenoids.
- Published
- 2013
44. Structural revision of methyl tortuoate D, abis-cembranoid from HainanSarcophyton tortuosumand its absolute stereochemistry
- Author
-
Ling-Li He, Yu-Fen Li, Hai-Li Liu, Hong-Bin Zhang, Lin-Fu Liang, and Yue-Wei Guo
- Subjects
Pharmacology ,Circular dichroism ,Molecular Structure ,Stereochemistry ,Oceans and Seas ,Organic Chemistry ,Sarcophyton tortuosum ,Absolute configuration ,Methyl tortuoate D ,Pharmaceutical Science ,General Medicine ,Biology ,Anthozoa ,Analytical Chemistry ,Lobophytum pauciflorum ,Complementary and alternative medicine ,Drug Discovery ,Animals ,Molecular Medicine ,Diterpenes ,Drug Screening Assays, Antitumor ,Nuclear Magnetic Resonance, Biomolecular - Abstract
Methyl tortuoate D (1), together with five other known related bis-cembranoids, was isolated from Hainan soft coral Sarcophyton tortuosum. The structure of methyl tortuoate D (1a), firstly isolated and reported by Li et al. from the title organism, was corrected as 1 by an extensive analysis of its one-dimensional and two-dimensional nuclear magnetic resonance data and by comparison with those reported in the literature. In addition, lobophytone K (1b), recently isolated from Hainan soft coral Lobophytum pauciflorum by Lin et al., was proved to be the same compound as 1 and 1a. The absolute configuration of 1 was determined by comparing its electronic circular dichroism curve with that of co-occurring ximaolide A (2).
- Published
- 2013
45. Bioactive polyhydroxylated steroids from the Hainan soft coral Sinularia depressa Tixier-Durivault
- Author
-
Le-Fu Lan, Hai-Yan Zhang, Xu-Jie Wang, Jia Li, Wen Zhang, Yue-Wei Guo, Hai-Li Liu, and Lin-Fu Liang
- Subjects
Stereochemistry ,medicine.medical_treatment ,Clinical Biochemistry ,Pharmaceutical Science ,Microbial Sensitivity Tests ,Hydroxylation ,medicine.disease_cause ,Biochemistry ,Steroid ,Structure-Activity Relationship ,chemistry.chemical_compound ,Cell Line, Tumor ,Drug Discovery ,medicine ,Animals ,Humans ,Structure–activity relationship ,Bioassay ,Molecular Biology ,Oleanolic acid ,Molecular Structure ,Organic Chemistry ,Stereoisomerism ,Anthozoa ,In vitro ,chemistry ,Staphylococcus aureus ,Molecular Medicine ,Steroids ,Antibacterial activity - Abstract
Two new steroids, (2β,3β,4α,5α,8β)-4-methylergost-24(28)-ene-2,3,8-triol (1) and (3β,7α)-24-methyl-7-hydroperoxycholest-5,24(28)-diene-3-ol (2), together with 13 known analogues (3-15) were isolated from the soft coral Sinularia depressa Tixier-Durivault. The structures of the new compounds were elucidated by detailed spectroscopic analysis and comparison with reported data. In the bioassay in vitro, compounds 3a, 4, and 14 exhibited potent PTP1B inhibitory activity, being similar as that of positive control oleanolic acid. Compound 14 also displayed a notable neuroprotective activity against both amyloid-β(25-35)- and serum deprivation-induced injuries in SH-SY5Y cells while compound 11 showed a considerable antibacterial activity against Staphylococcus aureus. Preliminary structure-activity relationships of these steroids were discussed.
- Published
- 2013
46. Yalongenes A and B, Two New Cembranoids with Cytoprotective Effects from the Hainan Soft Coral Sarcophyton trocheliophorumMarenzeller
- Author
-
Xian-Jun Guo, Shui-Chun Mao, Li-Gong Yao, Yue-Wei Guo, Lin-Fu Liang, and Hai-Yan Zhang
- Subjects
South china ,biology ,Sarcophyton ,Stereochemistry ,Chemistry ,Coral ,Organic Chemistry ,Cell injury ,biology.organism_classification ,Biochemistry ,Catalysis ,Inorganic Chemistry ,Drug Discovery ,Sarcophyton trocheliophorum ,Physical and Theoretical Chemistry - Abstract
Two new cembranoids, yalongenes A (1) and B (2), were isolated from the South China Sea soft coral Sarcophyton trocheliophorumMarenzeller. Their structures were elucidated by detailed spectroscopic analysis (IR, MS, and NMR) and by comparison with a related model compound. Yalongenes 1 and 2 were evaluated for their cytoprotective effects on SH-SY5Y cell injury induced by H2O2in vitro, and the result showed that only compound 1 had a significant cytoprotective activity at the concentration of 1 μM.
- Published
- 2012
47. Brominated polyunsaturated lipids with protein tyrosine phosphatase-1B inhibitory activity from Chinese marine sponge Xestospongia testudinaria
- Author
-
Wen-Fei He, Lin-Fu Liang, Li-Xin Gao, You-Sheng Cai, Yue-Wei Guo, Jia Li, Yu-Fen Li, and Hai-Li Liu
- Subjects
Stereochemistry ,Pharmaceutical Science ,Marine Biology ,Biology ,Inhibitory postsynaptic potential ,Analytical Chemistry ,Xestospongia testudinaria ,chemistry.chemical_compound ,Drug Discovery ,Acetone ,Animals ,Oleanolic Acid ,IC50 ,Oleanolic acid ,Netherlands ,Pharmacology ,Protein Tyrosine Phosphatase, Non-Receptor Type 1 ,Molecular Structure ,Diazomethane ,Organic Chemistry ,General Medicine ,biology.organism_classification ,Protein Tyrosine Phosphatase 1B ,Hydrocarbons, Brominated ,Porifera ,Xestospongia ,Sponge ,Complementary and alternative medicine ,chemistry ,Biochemistry ,Diabetes Mellitus, Type 2 ,Fatty Acids, Unsaturated ,Molecular Medicine - Abstract
A new brominated polyunsaturated lipid, methyl (E,E)-14,14-dibromo-4,6,13-tetradecatrienoate (1), along with three known related analogues (2–4), were isolated from the Et2O-soluble portion of the acetone extract of Chinese marine sponge Xestospongia testudinaria treated with diazomethane. The structure of the new compound was elucidated by detailed spectroscopic analysis and by comparison with literature data. Compound 3 exhibited significant inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), a key target for the treatment of type II diabetes and obesity, with an IC50 value of 5.30 ± 0.61 μM, when compared to the positive control oleanolic acid (IC50 = 2.39 ± 0.26 μM).
- Published
- 2015
48. ChemInform Abstract: Sarsolenane and Capnosane Diterpenes from the Hainan Soft Coral Sarcophyton trocheliophorum Marenzeller as PTP1B Inhibitors
- Author
-
Jia Li, Wen Zhang, Attila Mándi, Li-Xin Gao, Yue-Wei Guo, Lin Fu Liang, and Tibor Kurtán
- Subjects
Terpene ,Chemistry ,Stereochemistry ,Coral ,Sarcophyton trocheliophorum ,Absolute configuration ,General Medicine ,Protein tyrosine phosphatase ,Related derivatives - Abstract
Two new sarsolenane diterpenes, dihydrosarsolenone (2), methyl dihydrosarsolenoneate (3), and two new capnosane diterpenes, sarsolilides B (5) and C (6), were isolated together with the known analogue, sarsolilide A (4), from the Hainan soft coral Sarcophyton trocheliophorum Marenzeller. Their structures were elucidated by detailed spectroscopic analysis and by comparison with reported data, leading to a structure revision of sarsolenone (1). The absolute configurations of 2 and 5 were determined by TDDFT ECD calculations, and they could be used as ECD reference compounds in the determination of the absolute configuration of their related derivatives. Compounds 4 and 5 exhibited inhibitory activity in vitro against protein tyrosine phosphatases 1B (PTP1B), representing the first report of PTP1B inhibitory activity for capnosane diterpenes.
- Published
- 2015
49. [Review on the secondary metabolites from Xestospongia sponges and their bioactivities]
- Author
-
Lin-Fu, Liang, Hai-Li, Liu, Yu-Fen, Li, Wen-Quan, Ma, Yue-Wei, Guo, and Wen-Fei, He
- Subjects
Xestospongia ,Animals ,Secondary Metabolism - Abstract
The genus Xestospongia is one of the most widespread genera of sponges, containing abundant secondary metatolites with novel structures and potent bioactivities. The main structure types of secondary metatolites found in this genus are alkaloids, quinines, terpens, steroids, lipids, polyketones, etc. These metatolites exhibit a variety of bioactivities, such as cytotoxic, antibacterial and antiviral activities. This paper reviews the progress in the chemistry and pharmacological activities of the second metabolities from sponges of Xestospongia, especially for recent five years, with the aim for further research.
- Published
- 2014
50. ChemInform Abstract: Terpenes from the Soft Corals of the Genus Sarcophyton: Chemistry and Biological Activities
- Author
-
Yue-Wei Guo and Lin-Fu Liang
- Subjects
Terpene ,biology ,Genus ,Sarcophyton ,Stereochemistry ,Chemistry ,Botany ,Structural diversity ,General Medicine ,biology.organism_classification - Abstract
This review covers structural diversity and biological activities of terpenes from soft corals of the genus of Sarcophyton, reported from 1995 to July, 2011. During this period, besides undefined species, 16 species of the genus Sarcophyton, from different geographical areas, had been chemically examined. Two hundred and five terpenes had been isolated from this genus, including eleven sesquiterpenes, 165 diterpenes, 29 biscembranoids, some of which had novel skeletons. They exhibited various biological features, such as antifeedant, anti-inflammatory, antiviral, and antifouling activities.
- Published
- 2014
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