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A new 5α,8α-epidioxysterol with immunosuppressive activity from the South China Sea soft coral Sinularia sp
- Source :
- Natural Product Research. 34:1814-1819
- Publication Year :
- 2019
- Publisher :
- Informa UK Limited, 2019.
-
Abstract
- A new 5α,8α-epidioxysterol, namely yalongsterol A (1), along with two known related steroids 5α,8α-epidioxy-24-methyl-cholesta-6,24(28)-dien-3β-ol (2) and (22E,24S)-5α,8α-epidioxy-24-methyl-cholesta-6,22-dien-3β-ol (3), were isolated from the South China Sea soft coral Sinularia sp. Their structures were established by extensive spectroscopic analyses and comparisons of the spectral data with those reported in the literature. In bioassay, compounds 1-3 showed moderate immunosuppressive activities against T and/or B lymphocyte cells with IC50 values ranging from 19.30 to 59.49 μM, and low cytotoxicity on murine splenocytes with CC50 values ranging from 40.88 to 62.29 μM.[Formula: see text].
- Subjects :
- South china
biology
010405 organic chemistry
Chemistry
Lymphocyte
Coral
Organic Chemistry
Epidioxysterol
Plant Science
biology.organism_classification
01 natural sciences
Biochemistry
0104 chemical sciences
Analytical Chemistry
Microbiology
010404 medicinal & biomolecular chemistry
medicine.anatomical_structure
Ic50 values
medicine
Bioassay
Sinularia
Cytotoxicity
Subjects
Details
- ISSN :
- 14786427 and 14786419
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Natural Product Research
- Accession number :
- edsair.doi...........1be7f6e4628959b0b6d40d9de419016b