Search

Your search keyword '"Lin, Yunfan"' showing total 37 results
Start Over Author "Lin, Yunfan"
37 results on '"Lin, Yunfan"'

5. Analysis of Fault Mode of Variable Geometry Component on Variable Cycle Engine

Author

Lin, Yunfan, Tang, Hailong, Chen, Min, Zhang, Jiyuan, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Tan, Kay Chen, Series Editor, and Fu, Song, editor

Published
2024
Full Text
View/download PDF

15. Optimizing CD8+ T cell-based immunotherapy via metabolic interventions: a comprehensive review of intrinsic and extrinsic modulators.

Author

Zhou, Zihao, Zheng, Jiarong, Lu, Ye, Mai, Zizhao, Lin, Yunfan, Lin, Pei, Zheng, Yucheng, Chen, Xu, Xu, Rongwei, Zhao, Xinyuan, and Cui, Li

Subjects
T cells, TREATMENT effectiveness, TRANSMISSIBLE tumors, COMMUNICABLE diseases, CD8 antigen
Abstract

CD8+ T cells are integral to the effective management of cancer and infectious diseases due to their cytotoxic functions. The efficacy of these cells is profoundly influenced by their metabolic state, which regulates their activation, differentiation, and longevity. Accordingly, the modulation of metabolic pathways within CD8+ T cells is crucial for enhancing the effectiveness of T cell-based immunotherapy. Precise metabolic control is paramount in optimizing therapeutic outcomes and minimizing potential toxicities associated with treatment. Importantly, the potential of exogenous metabolites to augment CD8+ T cell responses is critically evaluated, especially through in vivo evidence that underscores their therapeutic promise. This review also addresses current challenges, including the need for precise control of metabolic modulation to avoid adverse effects, the development of targeted delivery systems to ensure efficient metabolite delivery to CD8+ T cells, and the inherent variability of metabolic states among patients that may influence treatment outcomes. Addressing these hurdles will be crucial for the successful integration of metabolic interventions into established immunotherapeutic regimens. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

17. Mixing Insulating Commodity Polymers with Semiconducting n‐type Polymers Enables High‐Performance Electrochemical Transistors

Author

Zeglio, Erica, primary, Wang, Yazhou, additional, Jain, Saumey, additional, Lin, Yunfan, additional, Avila Ramirez, Alan Eduardo, additional, Feng, Kui, additional, Guo, Xugang, additional, Ose, Helena, additional, Mozolevskis, Gatis, additional, Mawad, Damia, additional, Yue, Wan, additional, Hamedi, Mahiar Max, additional, and Herland, Anna, additional

Published
2024
Full Text
View/download PDF

18. Cleanroom‐Free Direct Laser Micropatterning of Polymers for Organic Electrochemical Transistors in Logic Circuits and Glucose Biosensors

Author

Enrico, Alessandro, Buchmann, Sebastian, De Ferrari, Fabio, Lin, Yunfan, Wang, Yazhou, Yue, Wan, Mårtensson, Gustaf, Stemme, Göran, Hamedi, Mahiar, Niklaus, Frank, Herland, Anna, Zeglio, Erica, Enrico, Alessandro, Buchmann, Sebastian, De Ferrari, Fabio, Lin, Yunfan, Wang, Yazhou, Yue, Wan, Mårtensson, Gustaf, Stemme, Göran, Hamedi, Mahiar, Niklaus, Frank, Herland, Anna, and Zeglio, Erica

Abstract

Organic electrochemical transistors (OECTs) are promising devices for bioelectronics, such as biosensors. However, current cleanroom-based microfabrication of OECTs hinders fast prototyping and widespread adoption of this technology for low-volume, low-cost applications. To address this limitation, a versatile and scalable approach for ultrafast laser microfabrication of OECTs is herein reported, where a femtosecond laser to pattern insulating polymers (such as parylene C or polyimide) is first used, exposing the underlying metal electrodes serving as transistor terminals (source, drain, or gate). After the first patterning step, conducting polymers, such as poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS), or semiconducting polymers, are spin-coated on the device surface. Another femtosecond laser patterning step subsequently defines the active polymer area contributing to the OECT performance by disconnecting the channel and gate from the surrounding spin-coated film. The effective OECT width can be defined with high resolution (down to 2 µm) in less than a second of exposure. Micropatterning the OECT channel area significantly improved the transistor switching performance in the case of PEDOT:PSS-based transistors, speeding up the devices by two orders of magnitude. The utility of this OECT manufacturing approach is demonstrated by fabricating complementary logic (inverters) and glucose biosensors, thereby showing its potential to accelerate OECT research., QC 20240123

Published
2024
Full Text
View/download PDF

19. Mixing Insulating Commodity Polymers with Semiconducting n‐type Polymers Enables High‐Performance Electrochemical Transistors

Author

Zeglio, Erica, Wang, Yazhou, Jain, Saumey, Lin, Yunfan, Avila Ramirez, Alan Eduardo, Feng, Kui, Guo, Xugang, Ose, Helena, Mozolevskis, Gatis, Mawad, Damia, Yue, Wan, Hamedi, Max Mahiar, Herland, Anna, Zeglio, Erica, Wang, Yazhou, Jain, Saumey, Lin, Yunfan, Avila Ramirez, Alan Eduardo, Feng, Kui, Guo, Xugang, Ose, Helena, Mozolevskis, Gatis, Mawad, Damia, Yue, Wan, Hamedi, Max Mahiar, and Herland, Anna

Abstract

Diluting organic semiconductors with a host insulating polymer is used to increase the electronic mobility in organic electronic devices, such as thin film transistors, while considerably reducing material costs. In contrast to organic electronics, bioelectronic devices such as the organic electrochemical transistor (OECT) rely on both electronic and ionic mobility for efficient operation, making it challenging to integrate hydrophobic polymers as the predominant blend component. This work shows that diluting the n-type conjugated polymer p(N-T) with high molecular weight polystyrene (10 KDa) leads to OECTs with over three times better mobility-volumetric capacitance product (µC*) with respect to the pristine p(N-T) (from 4.3 to 13.4 F V−1 cm−1 s−1) while drastically decreasing the amount of conjugated polymer (six times less). This improvement in µC* is due to a dramatic increase in electronic mobility by two orders of magnitude, from 0.059 to 1.3 cm2 V−1 s−1 for p(N-T):Polystyrene 10 KDa 1:6. Moreover, devices made with this polymer blend show better stability, retaining 77% of the initial drain current after 60 minutes operation in contrast to 12% for pristine p(N-T). These results open a new generation of low-cost organic mixed ionic-electronic conductors where the bulk of the film is made by a commodity polymer., QC 20240429

Published
2024
Full Text
View/download PDF

20. Cleanroom‐Free Direct Laser Micropatterning of Polymers for Organic Electrochemical Transistors in Logic Circuits and Glucose Biosensors

Author

Enrico, Alessandro, primary, Buchmann, Sebastian, additional, De Ferrari, Fabio, additional, Lin, Yunfan, additional, Wang, Yazhou, additional, Yue, Wan, additional, Mårtensson, Gustaf, additional, Stemme, Göran, additional, Hamedi, Mahiar Max, additional, Niklaus, Frank, additional, Herland, Anna, additional, and Zeglio, Erica, additional

Published
2024
Full Text
View/download PDF

24. Microglia-derived PDGFB promotes neuronal potassium currents to suppress basal sympathetic tonicity and limit hypertension

Author

Bi, Qianqian, primary, Wang, Chao, additional, Cheng, Guo, additional, Chen, Ningting, additional, Wei, Bo, additional, Liu, Xiaoli, additional, Li, Li, additional, Lu, Cheng, additional, He, Jian, additional, Weng, Yuancheng, additional, Yin, Chunyou, additional, Lin, Yunfan, additional, Wan, Shu, additional, Zhao, Li, additional, Xu, Jiaxi, additional, Wang, Yi, additional, Gu, Yan, additional, Shen, Xiao Z., additional, and Shi, Peng, additional

Published
2022
Full Text
View/download PDF

25. Grand Challenges of Machine-Vision Technology in Civil Structural Health Monitoring

Author

Lin Yunfan, Minghui Yao, Zou Xiangjun, Xueyu Huang, Tang Yunchao, and Huang Zhaofeng

Subjects
Engineering management, Engineering, Machine vision, business.industry, Deep learning, General Medicine, Artificial intelligence, Structural health monitoring, business, Civil infrastructure, Condition assessment, Grand Challenges, Computer technology
Abstract

Machine-vision technology has progressed remarkably in both accuracy and speed owing to advances in computer technology and artificial intelligence. In this paper, state-of-the-art research on vision-based techniques is reviewed for civil infrastructure condition assessment. The major challenges of machine vision technique in civil structural health monitoring are presented.

Published
2020
Full Text
View/download PDF

26. Organic Electrochemical Transistors for the Detection of Xanthine

Author

Lin, Yunfan

Subjects
Xanthine; OECT; Biosensor; PIBET-AO; Xanthine Oxidase (XOD), Xantin; OECT; Biosensor; PIBET-AO; Xantinoxidas (XOD), Electrical Engineering, Electronic Engineering, Information Engineering, Elektroteknik och elektronik
Abstract

Food waste is gradually becoming a serious global issue in recent decades. It is reported that more than 1.3 billion tonnes of food consisting of around 50 % meat products are wasted every year on a global scale, while there are more than 800 million of the global population who are starving at the same time. Therefore, a biosensor that can tell the freshness of food can be one of the solutions to reduce food waste, especially for fish, meat, and dairy products. Xanthine, a purine base derived from adenosine triphosphate (ATP), has been widely used as the analyte for detecting meat freshness. Xanthine is a common specie in all living organisms, but the death of a creature will lead to its accumulation of xanthine. So far, most sensing techniques for xanthine are designed based on traditional electrochemical biosensors. In this project, the sensing system is designed based on both an electrochemical platform and OECT. The OECT has a different working principle with respect to standard electrochemical setups and a huge potential to be used for several sensing applications. A p-type conjugated polymer is deposited on the devices by simple methods including drop casting and spin coating. During the project, the electrochemical biosensors were successfully produced and tested under four different conditions. The results show that PIBET-AO itself can exhibit sensing ability toward xanthine and, after adding the enzyme xanthine oxidase (XOD), the oxidation peak is shifted. Immobilization of XOD may allow the biosensor to work better at lower concentrations of xanthine. In addition to electrochemical biosensors, OECTs with PIBET-AO were fabricated and evaluated. The current result shows that the lowest concentration that can be measured is 50 − 100 µM. Since xanthine biosensor based on OECT has been rarely reported, more investigations should be performed to improve the sensing ability in the future. Matsvinn har gradvis blivit en allvarlig global fråga under de senaste decennierna. Det rapporteras att mer än 1,3 miljarder ton mat som består av cirka 50 % köttprodukter slängs varje år globalt. Samtidigt svälter mer än 800 miljoner av världens befolkning. Därför kan en biosensor för att avgöra köttets färskhet vara en av lösningarna för att minska matsvinnet, speciellt för kött som fisk, kyckling och så vidare. Xantin, en purinbas som härrör från adenosintrifosfat (ATP), har använts i stor utsträckning som analyt för att detektera köttets färskhet. Xantin är en vanlig art i alla levande organismer men däremot så kan varelsens död leda till ackumulering av xantin. Hittills är de flesta analystekniker för xantin designade för att vara baserad på traditionella elektrokemiska biosensorer. I detta projekt så är designen för analyssystemet baserat på både elektrokemisk plattform och OECT. OECT har en annorlunda arbetsprincip och har en enorm potential att användas inom fler områden i framtiden. En konjugerad polymer av p-typ beläggs på anordningarna med enkla metoder inklusive droppgjutning och spinnbeläggning. Under projektets gång producerades de elektrokemiska biosensorerna framgångsrikt och testades under fyra olika förhållanden. Resultaten visar att PIBET-AO själv kan uppvisa analysförmåga mot xantien och efter tillsats av XOD skiftade oxidationstoppen. Immobilisering av XOD kan göra att biosensorn fungerar bättre vid högre koncentrationer av xantin. Å andra sidan tillverkades och utvärderades OECTs med PIBET-AO. Det aktuella resultatet visar att den lägsta koncentrationen vi kan mäta är 50 − 100 µM. Eftersom xantinbiosensor baserad på OECT sällan har rapporterats bör fler undersökningar slutföras för att förbättra analysförmågan i framtiden.

Published
2022

28. Epitranscriptomic modifications in mesenchymal stem cell differentiation: advances, mechanistic insights, and beyond

Author

Zheng, Jiarong, Lu, Ye, Lin, Yunfan, Si, Shanshan, Guo, Bing, Zhao, Xinyuan, and Cui, Li

Abstract

RNA modifications, known as the “epitranscriptome”, represent a key layer of regulation that influences a wide array of biological processes in mesenchymal stem cells (MSCs). These modifications, catalyzed by specific enzymes, often termed “writers”, “readers”, and “erasers”, can dynamically alter the MSCs’ transcriptomic landscape, thereby modulating cell differentiation, proliferation, and responses to environmental cues. These enzymes include members of the classes METTL, IGF2BP, WTAP, YTHD, FTO, NAT, and others. Many of these RNA-modifying agents are active during MSC lineage differentiation. This review provides a comprehensive overview of the current understanding of different RNA modifications in MSCs, their roles in regulating stem cell behavior, and their implications in MSC-based therapies. It delves into how RNA modifications impact MSC biology, the functional significance of individual modifications, and the complex interplay among these modifications. We further discuss how these intricate regulatory mechanisms contribute to the functional diversity of MSCs, and how they might be harnessed for therapeutic applications. The review also highlights current challenges and potential future directions in the study of RNA modifications in MSCs, emphasizing the need for innovative tools to precisely map these modifications and decipher their context-specific effects. Collectively, this work paves the way for a deeper understanding of the role of the epitranscriptome in MSC biology, potentially advancing therapeutic strategies in regenerative medicine and MSC-based therapies.

Published
2023
Full Text
View/download PDF

29. Vision-Based Three-Dimensional Reconstruction and Monitoring of Large-Scale Steel Tubular Structures

Author

Lijuan Li, Lin Yunfan, Yuxin He, Mingyou Chen, Xueyu Huang, Yunchao Tang, and Kuangyu Huang

Subjects
Accuracy and precision, Article Subject, Scale (ratio), Computer science, Machine vision, business.industry, Deep learning, Point cloud, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, 02 engineering and technology, Deformation (meteorology), Engineering (General). Civil engineering (General), 01 natural sciences, 010309 optics, Image stitching, 0103 physical sciences, 0202 electrical engineering, electronic engineering, information engineering, Eye tracking, 020201 artificial intelligence & image processing, Computer vision, Artificial intelligence, TA1-2040, business, Civil and Structural Engineering
Abstract

A four-ocular vision system is proposed for the three-dimensional (3D) reconstruction of large-scale concrete-filled steel tube (CFST) under complex testing conditions. These measurements are vitally important for evaluating the seismic performance and 3D deformation of large-scale specimens. A four-ocular vision system is constructed to sample the large-scale CFST; then point cloud acquisition, point cloud filtering, and point cloud stitching algorithms are applied to obtain a 3D point cloud of the specimen surface. A point cloud correction algorithm based on geometric features and a deep learning algorithm are utilized, respectively, to correct the coordinates of the stitched point cloud. This enhances the vision measurement accuracy in complex environments and therefore yields a higher-accuracy 3D model for the purposes of real-time complex surface monitoring. The performance indicators of the two algorithms are evaluated on actual tasks. The cross-sectional diameters at specific heights in the reconstructed models are calculated and compared against laser rangefinder data to test the performance of the proposed algorithms. A visual tracking test on a CFST under cyclic loading shows that the reconstructed output well reflects the complex 3D surface after correction and meets the requirements for dynamic monitoring. The proposed methodology is applicable to complex environments featuring dynamic movement, mechanical vibration, and continuously changing features.

Published
2020

33. Tumor Microenvironment-Derived Exosomes: A Double-Edged Sword for Advanced T Cell-Based Immunotherapy

Author

Lu, Ye, Zheng, Jiarong, Lin, Pei, Lin, Yunfan, Zheng, Yucheng, Mai, Zizhao, Chen, Xu, Xia, Tian, Zhao, Xinyuan, and Cui, Li

Abstract

The tumor microenvironment (TME) plays a crucial role in cancer progression and immune evasion, partially mediated by the activity of the TME-derived exosomes. These extracellular vesicles are pivotal in shaping immune responses through the transfer of proteins, lipids, and nucleic acids between cells, facilitating a complex interplay that promotes tumor growth and metastasis. This review delves into the dual roles of exosomes in the TME, highlighting both their immunosuppressive functions and their emerging therapeutic potential. Exosomes can inhibit T cell function and promote tumor immune escape by carrying immune-modulatory molecules, such as PD-L1, yet they also hold promise for cancer therapy as vehicles for delivering tumor antigens and costimulatory signals. Additionally, the review discusses the intricate crosstalk mediated by exosomes among various cell types within the TME, influencing both cancer progression and responses to immunotherapies. Moreover, this highlights current challenges and future directions. Collectively, elucidating the detailed mechanisms by which TME-derived exosomes mediate T cell function offers a promising avenue for revolutionizing cancer treatment. Understanding these interactions allows for the development of targeted therapies that manipulate exosomal pathways to enhance the immune system’s response to tumors.

Published
2024
Full Text
View/download PDF

34. An Approach For Creating Low-fidelity Prototypes That Allow for Testing Integrated Digital And Physical Interfaces

Author

Lin, Yunfan

Subjects
Industrial and Graphic Design
Abstract

With the development of electronic products and electronic technology, the interaction between the user and the device design ushers in new challenges. Touch operations are gradually replacing traditional physical operations, and in the process of this transformation, problems arise. The advantages and shortcomings of new interactive interfaces have been exposed in terms of safety, ease of use and convenience. How to take advantage of the advantages of new interactive interfaces and optimize or eliminate the shortcomings of new interactive interfaces has become a challenge for today's designers in interaction design. The understanding of usability in design during the product development stage enhances the significance of usability testing of digital devices in early development stage. Therefore, a large number of prototypes are needed for testing. In the development process, various simulation models are produced and applied for usability testing. However, existing models are not sufficient to evaluate the usability of user interfaces (UIs) because they do not allow one to assess usability in both cognitive and physical ways. The challenges of prototyping are also great and involve knowledge of circuitry, programming, and other areas that are often unfamiliar to industrial designers. This study utilizes the tools and techniques that designers are familiar with to enable the creation and testing of prototypes, that can help designers better balance the choice of the implementation medium when designing new interactive interfaces.

Published
2022

35. P-type accumulation mode organic electrochemical transistor biosensor for xanthine detection in fish.

Author

Lin Y, Kroon R, Zeglio E, and Herland A

Abstract

Food waste is a global challenge that needs to be mitigated in the development of more sustainable societies. From manufacturers to customers, food biosensors could effectively reduce the amount of discarded food and provide more precise predictions of freshness with respect to pre-decided expiration dates. In this study, we developed a novel organic electrochemical transistor (OECT)-based xanthine biosensor. The OECT-based biosensor is based on the p-type conjugated polymer, p(g 4 2T-TT) as the channel, and incorporated xanthine oxidase (XOD) as the biorecognition element. The OECT thus acts as a transducer and amplifier of the enzymatic oxidation of xanthine. Real-time monitoring of xanthine using the OECT-based biosensor led to a linear range between 5 and 98 μM (R 2 =0.989), 3.28 μM limit of detection, and high sensitivity up to 21.8 mA/mM. Real sample tests showed that the biosensor can detect the accumulation of xanthine in fish meat from 0 to 6 days of degradation. Interference tests with ascorbic acid and uric acid and spike-and-recovery tests with fish samples indicated that as-designed biosensors have good selectivity and accuracy. The developed biosensors show great potential for point-of-care testing applied to food monitoring., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024. Published by Elsevier B.V.)

Published
2024
Full Text
View/download PDF

36. Development and Validation of a Cholesterol-related Gene Signature for Prognostic Assessment in Head and Neck Squamous Cell Carcinoma.

Author

Zheng J, Shu D, Xu R, Zheng Y, Lin P, Lin Y, Zhao X, Cui L, Liao X, and Guo B

Abstract

Aim: This study seeks to develop a prognostic risk signature for head and neck squamous cell carcinoma (HNSCC) based on cholesterol-related genes (CholRG), aiming to enhance prognostic accuracy in clinical practice., Background: HNSCC poses significant challenges due to its aggressive behavior and limited response to standard treatments, resulting in elevated morbidity and mortality rates.In order to improve prognostic prediction in HNSCC, our study is inspired by the realization that cholesterol metabolism plays a critical role in accelerating the progression of cancer. To this end, we are developing a unique risk signature using CholRG., Objective: The aim of this study was to create a CholRG-based risk signature to predict HNSCC prognosis, aiding in clinical decision-making accurately., Method: The TCGA HNSCC dataset, along with GSE41613 and GSE65858, was obtained from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases, respectively. A CholRG-based risk signature was then developed and validated across various independent HNSCC cohorts. Moreover, a nomogram model incorporating CholRG-based risk signature was established. Additionally, functional enrichment analysis was conducted, and the immune landscapes of the high- and low-risk groups were compared. Finally, in vitro experiments were performed using lipid-based transfection to deliver siRNAs targeting ACAT1 to SCC1 and SCC23 cell lines, further examining the effects of ACAT1 knockdown on these cells., Results: Utilizing RNA-seq, microarray, and clinical data from public databases, we constructed and validated a CholRG-based risk signature that includes key genes such as ACAT1, CYP19A1, CYP27A1, FAXDC2, INSIG2, PRKAA2, and SEC14L2, which can effectively predict the clinical outcome of HNSCC. Additionally, our findings were reinforced by a nomogram model that integrates the risk score with clinical variables for more clinically practical prognostic assessment. In addition, patients at high risk show hypoxia and increased oncogenic pathways such as mTORC1 signaling, as well as a suppressed immune microenvironment marked by a reduction in the infiltration of important immune cells. Notably, in vitro experiments showed that ACAT1 depletion significantly suppressed the proliferation, colony formation, and invasion capabilities of HNSCC cells, confirming ACAT1's role in promoting malignancy., Conclusion: Collectively, our study not only underscores the importance of cholesterol metabolism in HNSCC pathogenesis but also highlights the CholRG-based risk signature as a promising tool for enhancing prognostic accuracy and personalizing therapeutic strategies., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

Published
2024
Full Text
View/download PDF

37. Post-Translational Modifications of RNA-Modifying Proteins in Cellular Dynamics and Disease Progression.

Author

Lin Y, Lin P, Lu Y, Zheng J, Zheng Y, Huang X, Zhao X, and Cui L

Abstract

RNA-modifying proteins, classified as "writers," "erasers," and "readers," dynamically modulate RNA by adding, removing, or interpreting chemical groups, thereby influencing RNA stability, functionality, and interactions. To date, over 170 distinct RNA chemical modifications and more than 100 RNA-modifying enzymes have been identified, with ongoing research expanding these numbers. Although significant progress has been made in understanding RNA modification, the regulatory mechanisms that govern RNA-modifying proteins themselves remain insufficiently explored. Post-translational modifications (PTMs) such as phosphorylation, ubiquitination, and acetylation are crucial in modulating the function and behavior of these proteins. However, the full extent of PTM influence on RNA-modifying proteins and their role in disease development remains to be fully elucidated. This review addresses these gaps by offering a comprehensive analysis of the roles PTMs play in regulating RNA-modifying proteins. Mechanistic insights are provided into how these modifications alter biological processes, contribute to cellular function, and drive disease progression. In addition, the current research landscape is examined, highlighting the therapeutic potential of targeting PTMs on RNA-modifying proteins for precision medicine. By advancing understanding of these regulatory networks, this review seeks to facilitate the development of more effective therapeutic strategies and inspire future research in the critical area of PTMs in RNA-modifying proteins., (© 2024 The Author(s). Advanced Science published by Wiley‐VCH GmbH.)

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results