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1. The linkage disequilibrium maps of three human chromosomes across four populations reflect their demographic history and a common underlying recombination pattern

Author

De La Vega, Francisco M., Issac, Hadar, Collins, Andrew, Wogan, Lewis T., Ziegle, Janet S., Koehler, Ryan T., Laig-Webster, Marion, Yu Wang, Lippert, Ross A., Xiaoping Su, Halldorsson, Bjarni V., Scafe, Charles R., Stevens, Junko F., de The, Guy, Yi Zheng, Itakura, Mitsuo, Kalush, Francis, Hemken, Heinz G., Lily H. Xu, Xiaoqing You, Guegler, Karl J., Olson, Sheri J., Leinen, Kyle M., O'Brien, Stephen J., Spier, Eugene G., Hunkapiller, Michael W., Istrail, Sorin, and Clark, Andrew G.

Subjects
Linkage (Genetics) -- Research, Single nucleotide polymorphisms -- Research, Human chromosomes -- Research, Health
Abstract

A comparison of the patterns of linkage disequilibrium (LD) across four major human populations with a high-resolution single-nucleotide polymorphism (SNP) map covering almost the entire length of chromosomes 6, 21, and 22 is presented. Results are considered to have practical implications for the rational design and selection of SNPs for disease association studies.

Published
2005

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