The linkage disequilibrium maps of three human chromosomes across four populations reflect their demographic history and a common underlying recombination pattern

Authors :: De La Vega, Francisco M.
Issac, Hadar
Collins, Andrew
Wogan, Lewis T.
Ziegle, Janet S.
Koehler, Ryan T.
Laig-Webster, Marion
Yu Wang
Lippert, Ross A.
Xiaoping Su
Halldorsson, Bjarni V.
Scafe, Charles R.
Stevens, Junko F.
de The, Guy
Yi Zheng
Itakura, Mitsuo
Kalush, Francis
Hemken, Heinz G.
Lily H. Xu
Xiaoqing You
Guegler, Karl J.
Olson, Sheri J.
Leinen, Kyle M.
O'Brien, Stephen J.
Spier, Eugene G.
Hunkapiller, Michael W.
Istrail, Sorin
Clark, Andrew G.
Source :: Genome Research. April, 2005, Vol. 15 Issue 4, p454, 9 p.
Publication Year :: 2005
Abstract: A comparison of the patterns of linkage disequilibrium (LD) across four major human populations with a high-resolution single-nucleotide polymorphism (SNP) map covering almost the entire length of chromosomes 6, 21, and 22 is presented. Results are considered to have practical implications for the rational design and selection of SNPs for disease association studies.

Subjects :: Linkage (Genetics) -- Research
Single nucleotide polymorphisms -- Research
Human chromosomes -- Research
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