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32 results on '"Liberati, Fabrizio"'

1. Screening for colorectal cancer by full colonoscopy in first-degree relatives of colorectal cancer patients: a multicentric study by the Italian League for the Fight against Cancer.

Author

Diedenhofen, Giacomo, Morgia, Augusto, Sinnona, Nicola, Pacchiarotti, Alberto, Fiaschetti, Anna, Forte, Vito, Tosoni, Mauro, Liberati, Fabrizio, Boschetto, Sandro, Zepponi, Enrico, Marogna, Pietro, Manca, Alessandra, Bisail, Marco, Vestri, Annarita, and Rossi, Alessandro

Subjects
COLORECTAL cancer, COLONOSCOPY, CANCER patients, BLOOD testing, MEDICAL care
Abstract

Copyright of Annali di Igiene, Medicina Preventiva e di Comunità is the property of Societa Editrice Universo s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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2. PD-L1 testing in metastatic triple negative breast cancer: Results of an Italian survey

Author

Cerbelli, Bruna, primary, Cirillo, Alessio, additional, Pomati, Giulia, additional, Pernazza, Angelina, additional, Ascione, Andrea, additional, Pisegna, Simona, additional, Pisano, Annalinda, additional, Leopizzi, Martina, additional, Pignataro, Maria Gemma, additional, Costarelli, Leopoldo, additional, Mulè, Antonino, additional, Vecchione, Andrea, additional, Catalano, Piera, additional, Coppola, Luigi, additional, Perrone, Giuseppe, additional, Perracchio, Letizia, additional, Anemona, Lucia, additional, Mastracchio, Antonio, additional, Nardi, Stefano, additional, Reitano, Renato, additional, Massari, Annalisa, additional, Grillo, Lucia Rosalba, additional, Liberati, Fabrizio, additional, Della Rocca, Carlo, additional, Marchetti, Paolo, additional, Botticelli, Andrea, additional, and D’Amati, Giulia, additional

Published
2023
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4. PD-L1 testing in metastatic triple negative breast cancer: Results of an Italian survey

Author

Cerbelli, Bruna, Cirillo, Alessio, Pomati, Giulia, Pernazza, Angelina, Ascione, Andrea, Pisegna, Simona, Pisano, Annalinda, Leopizzi, Martina, Pignataro, Maria Gemma, Costarelli, Leopoldo, Mulè, Antonino, Vecchione, Andrea, Catalano, Piera, Coppola, Luigi, Perrone, Giuseppe, Perracchio, Letizia, Anemona, Lucia, Mastracchio, Antonio, Nardi, Stefano, Reitano, Renato, Massari, Annalisa, Grillo, Lucia Rosalba, Liberati, Fabrizio, Della Rocca, Carlo, Marchetti, Paolo, Botticelli, Andrea, and D’Amati, Giulia

Abstract

Background: Immunotherapy has revolutionized the approach to metastatic triple-negative breast cancers. Atezolizumab was approved for patients with metastatic triple-negative breast cancers whose tumors express PD-L1, determined by SP 142 assay. To assess the availability and practice of SP142 test we administered a survey to all the 15 pathology departments of the Lazio Region during a six-month period.Methods: The survey comprised 12 questions regarding the availability of SP142 in the pathology departments, the percentage of positive tests, the difficulties of pathologists in cases close to cut-off value and the tested samples.Results: The SP142 assay was available in only eight centers. In case of positive result, most centers (5/8, 62.5%) reported values of PD-L1 expression ranging from > 1 to ⩽ 5%, with values close to the cut-off point (⩾ 1% or < 1%) being the greatest challenge. Most of the centers (6/8, 75%) tested material from both their own and other hospitals. In most centers, the evaluations were performed either on primary tumors or metastasis, in particular lymph nodes (5/8, 62.5%), followed by lung (3/8, 37.5%) and liver (1/8, 12.5%) metastasis.Conclusion: Our results raise some important issues concerning the evaluation of PD-L1 in the “real-life” setting, providing strategies for its implementation.

Published
2024
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5. PD-L1 Testing In Metastatic Triple Negative Breast Cancer: Results Of An Italian Survey

Author

Cerbelli, Bruna, primary, Cirillo, Alessio, additional, Pomati, Giulia, additional, Pernazza, Angelina, additional, Ascione, Andrea, additional, Pisegna, Simona, additional, Pisano, Annalinda, additional, Leopizzi, Martina, additional, Pignataro, Maria Gemma, additional, Costarelli, Leopoldo, additional, Mulè, Antonino, additional, Vecchione, Andrea, additional, Catalano, Piera, additional, Coppola, Luigi, additional, Perrone, Giuseppe, additional, Perracchio, Letizia, additional, Anemona, Lucia, additional, Mastracchio, Antonio, additional, Nardi, Stefano, additional, Reitano, Renato, additional, Massari, Annalisa, additional, Grillo, Lucia Rosalba, additional, Liberati, Fabrizio, additional, Rocca, Carlo Della, additional, Marchetti, Paolo, additional, Botticelli, Andrea, additional, and D’Amati, Giulia, additional

Published
2022
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13. Sindrome di Birt-Hogg-Dubè (BHDs), questa sconosciuta! Una variante con nuova sequenza genomica.

Author

Pietrangeli, Vittorio, Pretto, Paolo, Cola, Silvia, Benedicenti, Francesco, Liberati, Fabrizio, and Triani, Antonio

Abstract

Copyright of Rassegna di Patologia dell'Apparato Respiratorio is the property of AIPO - Associazione Italiana Pneumologi Ospedalieri and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2017

14. The spectral imaging facility: Setup characterization

Author

De Angelis, Simone, primary, Ammannito, Eleonora, additional, Di Iorio, Tatiana, additional, De Sanctis, Maria Cristina, additional, Manzari, Paola Olga, additional, Liberati, Fabrizio, additional, Tarchi, Fabio, additional, Dami, Michele, additional, Olivieri, Monica, additional, Pompei, Carlo, additional, and Mugnuolo, Raffaele, additional

Published
2015
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15. Pyrometer at low radiation for measuring the forehead skin temperature

Author

Pezzotti, Gianni, Coppa, Paolo, and Liberati, Fabrizio

Subjects
pirómetro de baja radiación, skin temperature, thermopile, optical system, termo pila, sistema óptico, temperatura de la piel, low radiation pyrometer
Abstract

This paper presents the results of the design, construction, calibration and tests of a low radiation pyrometer for temperature measurement of the human body. The instrument is based on a low cost thermopile as detector and an optical system. It is specially designed to measure the forehead temperature of a person. It is useful in applications like: Measurement of temperature of people in the airports (to prevent contamination with contagious diseases infection) or applications in medicine as continuous monitoring of the temperature of patients in intensive care units at hospitals. The instrument has been calibrated using an on-purpose-built black body and its precision is of 0.19 ºC. Este artículo presenta el diseño, construcción, calibración y desempeño de un pirómetro de radiación para la determinación de la temperatura del cuerpo humano. El equipo se basa en un detector de bajo costo y un sistema óptico. Está especialmente diseñado para medir la temperatura de la frente de una persona. Puede aplicarse para determinar la temperatura corporal de viajeros en un aeropuerto (a fin de detectar posibles portadores de enfermedades contagiosas), o en aplicaciones médicas tales como el monitoreo de pacientes en las unidades de cuidado intensivo de los hospitales. El instrumento se calibró con un cuerpo negro construido específicamente para este propósito; se encontró que la precisión del instrumento es de 0,19 ºC.

Published
2006

30. New far infrared and millimetric telescopes for differential measurements with a large chopping angle in the sky

Author

De Petris, Marco, Gervasi, Massimo, and Liberati, Fabrizio

Abstract

The optical design of two Cassegrain-type telescopes of 1200- and 2500-mm primary mirrors has been studied by wobbling subreflectors to obtain differential measurements in wavelengths ranging from 300 μm to 2 mm of the spectrum. Wide chopping angles in the sky have been reached in spite of the large apertures and high secondary magnifications. Diffraction-limited performances are maintained by tilting the secondary mirror around the primary focus. This work is included in the TIR (Telescopio InfraRosso) project.

Published
1989

32. Screening for colorectal cancer by full colonoscopy in first-degree relatives of colorectal cancer patients: a multicentric study by the Italian League for the Fight against Cancer.

Author

Diedenhofen G, Morgia A, Sinnona N, Pacchiarotti A, Fiaschetti A, Forte V, Tosoni M, Liberati F, Boschetto S, Zepponi E, Marogna P, Manca A, Bisail M, Vestri A, and Rossi A

Subjects
Humans, Italy, Female, Male, Middle Aged, Aged, Adult, Mass Screening methods, Occult Blood, Colonoscopy, Colorectal Neoplasms diagnosis, Colorectal Neoplasms prevention & control, Early Detection of Cancer methods
Abstract

Background: Colorectal cancer currently presents the third-highest incidence of cancers worldwide, making secondary prevention through screening programs for colorectal cancer, usually by Fecal Occult Blood Testing, an essential preventive medicine intervention. First-degree relatives of colorectal cancer patients are a particularly at-risk group, with indications to consider direct screening by full colonoscopy. Colonoscopy is considered the gold standard for diagnosing colorectal cancer, as it has high sensitivity and specificity, and is both a diagnostic and therapeutic tool. However, it requires significant organizational and financial resources, and has a small but relatively higher risk of complications as opposed to fecal occult blood testing. The present study aimed to assess the appropriateness of a screening program without age restrictions of CRC by full colonoscopy in asymptomatic, first-degree adult relatives of patients with colorectal cancer, aiming both to actively increase screening coverage and to determine the detection rate of precancerous lesions and colorectal cancer in this population., Study Design: Uncontrolled interventional study - colorectal cancer screening by full colonoscopy for at-risk population., Methods: The Italian League for the Fight against Cancer started a colorectal cancer screening program by full colonoscopy for first-degree relatives of colorectal cancer patients in 1998 in the province of Latina, Lazio Region, Italy. The program was expanded to the provinces of Rieti, Lazio Region, and Sassari, Sardinia Region, in 2014 and 2016 respectively, and was concluded in 2018. Subjects were actively and voluntarily recruited by the study's working group. Subjects that had already been subjected to a full colonoscopy in the preceding 5 years were excluded from this study. Identified neoplastic lesions were treated either directly or referred to the Day Hospital setting, and histologically diagnosed following World Health Organization guidelines., Results: In total, 2,288 subjects (age range 15-88, mean 52.3 yrs, M/F = 946/1,204) were screened by colonoscopy, of which 103 (4.5%) were incomplete and 2,173 (95.0%) complete, with data on colonoscopy performance missing for 12 participants. Out of 468 positive outcomes on colonoscopy, diagnosis for 422 (204M/173F), 19.4% of total subjects, was adenomatous polyps and 46 (20M/20F), 2.1% of total subjects, was colorectal cancer. Female sex was a protective factor against a positive test outcome, with a 35% reduction compared to male sex, with OR=0.64 95%CI (0.52-0.80). On the other hand, being over 50 years of age was found to be a risk factor, making a positive outcome more than twice as likely, with OR=2.3 95%CI (1.8-2.9). Subjects over 50 also had significantly more instances of multiple adenomas being found, however the size distribution of found adenomas was not significantly different between subjects under and over 50, despite size being a predictor of risk of neoplastic progression., Conclusions: Given the high detection rate of precancerous lesions and colorectal cancer in the studied population, it is our opinion that guidelines should continue to recommend earlier and more frequent screening in first-degree relatives of patients with colorectal cancer, and, barring the introduction of more cost-effective and/or lower risk procedures with a similar efficacy profile, maintain the use of colonoscopy as the main screening option.

Published
2024
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