1. Analgesic Components from Bornean Medicinal Plants, Tabernaemontana pauciflora BLUME and Tabernaemontana pandacaqui POIR
- Author
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Emi Okuyama, Mikio Yamazaki, and Li Hon Gao
- Subjects
Male ,Stereochemistry ,Guinea Pigs ,Analgesic ,Mice, Inbred Strains ,Coronaridine ,Tabernaemontana pandacaqui ,Pharmacognosy ,Body Temperature ,Mice ,chemistry.chemical_compound ,Borneo ,Drug Discovery ,Animals ,Medicinal plants ,Voacangine ,Analgesics ,Plants, Medicinal ,Tabernaemontana pauciflora ,Traditional medicine ,Apocynaceae ,biology ,General Chemistry ,General Medicine ,biology.organism_classification ,chemistry - Abstract
The analgesic components were isolated from a Bornean medicinal plant, Tabernaemontana pauciflora BLUME (syn. Ervatamia blumeana MARK gr.), and the major components were identified as coronaridine and 3-(2-oxo-propyl)coronaridine. Four minor components were estimated to be 5R- and 5S-(2-oxopropyl)coronaridine, 3-(2-oxopropyl)voacangine and 3, 3'-(oxopropyl)dicoronaridine, which might be produced during the isolaion process. Voacangine was also isolated as a major component of T. pandacaqui POIR. Coronaridine and voacangine exhibited significant analgesic and hypothermic effects in mice at a dose of 25 mg/kg, p.o., while 3-(2-oxopropyl)coronaridine was less effective. The former two compounds also revealed a surface anesthesia.
- Published
- 1992
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