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Analgesic Components from Bornean Medicinal Plants, Tabernaemontana pauciflora BLUME and Tabernaemontana pandacaqui POIR
- Source :
- Chemical and Pharmaceutical Bulletin. 40:2075-2079
- Publication Year :
- 1992
- Publisher :
- Pharmaceutical Society of Japan, 1992.
-
Abstract
- The analgesic components were isolated from a Bornean medicinal plant, Tabernaemontana pauciflora BLUME (syn. Ervatamia blumeana MARK gr.), and the major components were identified as coronaridine and 3-(2-oxo-propyl)coronaridine. Four minor components were estimated to be 5R- and 5S-(2-oxopropyl)coronaridine, 3-(2-oxopropyl)voacangine and 3, 3'-(oxopropyl)dicoronaridine, which might be produced during the isolaion process. Voacangine was also isolated as a major component of T. pandacaqui POIR. Coronaridine and voacangine exhibited significant analgesic and hypothermic effects in mice at a dose of 25 mg/kg, p.o., while 3-(2-oxopropyl)coronaridine was less effective. The former two compounds also revealed a surface anesthesia.
- Subjects :
- Male
Stereochemistry
Guinea Pigs
Analgesic
Mice, Inbred Strains
Coronaridine
Tabernaemontana pandacaqui
Pharmacognosy
Body Temperature
Mice
chemistry.chemical_compound
Borneo
Drug Discovery
Animals
Medicinal plants
Voacangine
Analgesics
Plants, Medicinal
Tabernaemontana pauciflora
Traditional medicine
Apocynaceae
biology
General Chemistry
General Medicine
biology.organism_classification
chemistry
Subjects
Details
- ISSN :
- 13475223 and 00092363
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Chemical and Pharmaceutical Bulletin
- Accession number :
- edsair.doi.dedup.....417e00e77f8ece7db5188a74f279968d
- Full Text :
- https://doi.org/10.1248/cpb.40.2075