Back to Search Start Over

Analgesic Components from Bornean Medicinal Plants, Tabernaemontana pauciflora BLUME and Tabernaemontana pandacaqui POIR

Authors :
Emi Okuyama
Mikio Yamazaki
Li Hon Gao
Source :
Chemical and Pharmaceutical Bulletin. 40:2075-2079
Publication Year :
1992
Publisher :
Pharmaceutical Society of Japan, 1992.

Abstract

The analgesic components were isolated from a Bornean medicinal plant, Tabernaemontana pauciflora BLUME (syn. Ervatamia blumeana MARK gr.), and the major components were identified as coronaridine and 3-(2-oxo-propyl)coronaridine. Four minor components were estimated to be 5R- and 5S-(2-oxopropyl)coronaridine, 3-(2-oxopropyl)voacangine and 3, 3'-(oxopropyl)dicoronaridine, which might be produced during the isolaion process. Voacangine was also isolated as a major component of T. pandacaqui POIR. Coronaridine and voacangine exhibited significant analgesic and hypothermic effects in mice at a dose of 25 mg/kg, p.o., while 3-(2-oxopropyl)coronaridine was less effective. The former two compounds also revealed a surface anesthesia.

Details

ISSN :
13475223 and 00092363
Volume :
40
Database :
OpenAIRE
Journal :
Chemical and Pharmaceutical Bulletin
Accession number :
edsair.doi.dedup.....417e00e77f8ece7db5188a74f279968d
Full Text :
https://doi.org/10.1248/cpb.40.2075