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7. Construction and Analysis of Evaluation Model for Medical Students' Innovation Competency Based on Research-Oriented Biochemistry and Molecular Biology Course in China

Author

Fan, Guanhua, Huang, Zijian, Sun, Hong, Li, Zihua, Wu, Xiaoman, Li, Congsen, Lin, Chunbiao, Zhan, Weijie, Li, Zibo, Zheng, Chunwen, Xie, Weijie, Zou, Haiying, Wu, Bingli, Fang, Wangkai, Xu, Liyan, Yang, Mianhua, Zheng, Shaoyan, and Li, Enmin

Abstract

Presently, a variety of policies and measures has implemented to enhance the scientific research and innovation ability of medical students, but in the process of practice, there are many problems, such as they lack of independent topic selection ability, weak scientific research skills, lack of autonomous learning ability, the research results are simple and ineffective, limited teacher guidance time and so on. This paper attempted to build an effective model for the promotion of medical students' scientific research and innovation ability, in order to establish an efficacy evaluation model of the "Medical students' Innovative Scientific Research Program." Undergraduates, graduate assistants, and tutors were interviewed with the Behavioral Event Interview technique, and a questionnaire of efficacy evaluation characteristics concluded from the interviews was formed. The questionnaire was conducted on medical students in the Medical students' Innovative Scientific Research Program, and the constructed model was analyzed using reliability analysis, validity analysis, and variation analysis. At the same time, the experimental teaching models are summarized and combed, and compared with other methods such as independent sample test. The results show the model could effectively evaluate the efficacy of the Medical students' Innovative Scientific Research Program and its teaching model is effective in cultivating medical students' learning and scientific research ability. It can provide theoretical support and practical reference for the evaluation and reform of the teaching modes related to the cultivation of scientific and innovative ability of medical students.

Published
2023
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13. The Resilience Improvement Method of Distribution Network Including SOP

Author

Zhao, Jingjing, Li, Zibo, Liu, Shuai, Du, Ming, Zhang, Chaoli, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Xie, Kaigui, editor, Hu, Jianlin, editor, Yang, Qingxin, editor, and Li, Jian, editor

Published
2023
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26. Pre-clinical safety and efficacy evaluation of sodium chloride nanoparticles for treating non-muscle invasive bladder cancer.

Author

Gdowski, Andrew, primary, Kim, Lucia, additional, Lai, Xining, additional, Ma, Xinrui, additional, Raupp, John, additional, Zhan, Shuyue, additional, Beckabir, Wolfgang, additional, Sturdivant, Michael, additional, Wobker, Sara Elizabeth, additional, Li, Zibo, additional, Xie, Jin, additional, and Kim, William Y., additional

Published
2024
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36. Chelator boosted tumor-retention and pharmacokinetic properties: development of 64Cu labeled radiopharmaceuticals targeting neurotensin receptor.

Author

Zhang, Tao, Ma, Xinrui, Xu, Muyun, Cai, Jinghua, Cai, Jianhua, Cao, Yanguang, Zhang, Zhihao, Ji, Xin, He, Jian, Cabrera, German Oscar Fonseca, Wu, Xuedan, Zhao, Weiling, Wu, Zhanhong, Xie, Jin, and Li, Zibo

Subjects
POSITRON emission tomography, LEAD compounds, LIVER tumors, LUNG cancer, NEUROTENSIN
Abstract

Purpose: Accumulating evidence suggests that neurotensin (NTS) and neurotensin receptors (NTSRs) play key roles in lung cancer progression by triggering multiple oncogenic signaling pathways. This study aims to develop Cu-labeled neurotensin receptor 1 (NTSR1)-targeting agents with the potential for both imaging and therapeutic applications. Method: A series of neurotensin receptor antagonists (NRAs) with variable propylamine (PA) linker length and different chelators were synthesized, including [64Cu]Cu-CB-TE2A-iPA-NRA ([64Cu]Cu-4a-c, i = 1, 2, 3), [64Cu]Cu-NOTA-2PA-NRA ([64Cu]Cu-4d), [64Cu]Cu-DOTA-2PA-NRA ([64Cu]Cu-4e, also known as [64Cu]Cu-3BP-227), and [64Cu]Cu-DOTA-VS-2PA-NRA ([64Cu]Cu-4f). The series of small animal PET/CT were conducted in H1299 lung cancer model. The expression profile of NTSR1 was also confirmed by IHC using patient tissue samples. Results: For most of the compounds studied, PET/CT showed prominent tumor uptake and high tumor-to-background contrast, but the tumor retention was strongly influenced by the chelators used. For previously reported 4e, [64Cu]Cu-labeled derivative showed initial high tumor uptake accompanied by rapid tumor washout at 24 h. The newly developed [64Cu]Cu-4d and [64Cu]Cu-4f demonstrated good tumor uptake and tumor-to-background contrast at early time points, but were less promising in tumor retention. In contrast, our lead compound [64Cu]Cu-4b demonstrated 9.57 ± 1.35, 9.44 ± 2.38 and 9.72 ± 4.89%ID/g tumor uptake at 4, 24, and 48 h p.i., respectively. Moderate liver uptake (11.97 ± 3.85, 9.80 ± 3.63, and 7.72 ± 4.68%ID/g at 4, 24, and 48 h p.i.) was observed with low uptake in most other organs. The PA linker was found to have a significant effect on drug distribution. Compared to [64Cu]Cu-4b, [64Cu]Cu-4a had a lower background, including a greatly reduced liver uptake, while the tumor uptake was only moderately reduced. Meanwhile, [64Cu]Cu-4c showed increased uptake in both the tumor and the liver. The clinical relevance of NTSR1 was also demonstrated by the elevated tumor expression in patient tissue samples. Conclusions: Through the side-by-side comparison, [64Cu]Cu-4b was identified as the lead agent for further evaluation based on its high and sustained tumor uptake and moderate liver uptake. It can not only be used to efficiently detect NTSR1 expression in lung cancer (for diagnosis, patient screening, and treatment monitoring), but also has the great potential to treat NTSR-positive lesions once chelating to the beta emitter 67Cu. [ABSTRACT FROM AUTHOR]

Published
2024
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41. Hexafluoroisopropanol as a Bioconjugation Medium of Ultrafast, Tryptophan-Selective Catalysis

Author

Nuruzzaman, Mohammad, primary, Colella, Brandon M., additional, Uzoewulu, Chiamaka P., additional, Meo, Alissa E., additional, Gross, Elizabeth J., additional, Ishizawa, Seiya, additional, Sana, Sravani, additional, Zhang, He, additional, Hoff, Meredith E., additional, Medlock, Bryce T. W., additional, Joyner, Emily C., additional, Sato, Shinichi, additional, Ison, Elon A., additional, Li, Zibo, additional, and Ohata, Jun, additional

Published
2024
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49. Difluoromethoxide Is a Strong Leaving Group in the Photoredox Deoxyradiofluorination of 2-Phenylpyridines

Author

Jiang, Meijuan, Ellin, Nicholas R., Telu, Sanjay, Mungalpara, Maulik, Wu, Xuedan, Li, Zibo, Lu, Shuiyu, and Pike, Victor W.

Abstract

A 2-phenyl-3-difluoromethoxy-pyridinyl moiety features in potent phosphodiesterase 4D inhibitors that are considered to be candidate radiotracers for positron emission tomography if they are labeled with fluorine-18. Fluorine-18 could be installed as desired at the 3′-phenyl position with acridinium-mediated photoredox radiodeoxyfluorination in homologues bearing variously substituted 3′-aryloxy groups. However, a distal 3-difluoromethoxide (-OCHF2) group strongly competes as a leaving group, especially when an electron-deficient aryloxy group is present at position 3′. A yield of up to 50% may occur without observable 19F for 18F exchange.

Published
2024
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50. First-in-Human Evaluation of [18F]FDOPA Produced by Organo-Photoredox Reactions

Author

Wang, Li, Lv, Zhiyu, Yang, Liping, Wu, Xuedan, Zhu, Yan, Liu, Lin, Zhao, Yan, Huang, Zhanwen, Nicewicz, David A., Wu, Zhanhong, Chen, Yue, and Li, Zibo

Abstract

Photoredox is a powerful synthetic tool in organic chemistry and has been widely used in various fields, including nuclear medicine and molecular imaging. In particular, acridinium-based organophotoredox radiolabeling has significantly impacted the production and discovery of positron emission tomography (PET) agents. Despite their extensive use in preclinical research, no PET agents synthesized by acridinium photoredox labeling have been tested in humans. [18F]FDOPA is clinically used for tumor diagnosis and the evaluation of neuropsychiatric disorders, but its application is limited by complex synthesis methods, the need for expensive modules, and/or the high cost of consumable materials/cassettes. In this report, we integrated a photoredox labeling unit with an automated module and produced [18F]FDOPA for human study. This research not only represents the first human study of a PET agent generated by acridinium-based organophotoredox reactions but also demonstrates the safety of this novel labeling method, serving as a milestone/reference for the clinical translation of other PET agents generated by this technique in the future.

Published
2024
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