Search

Your search keyword '"Lewanczuk, Richard"' showing total 597 results
Start Over Author "Lewanczuk, Richard"
597 results on '"Lewanczuk, Richard"'

1. Harmonization of clinical practice guidelines for primary prevention and screening: actionable recommendations and resources for primary care

Author

Fernandes, Carolina, Campbell-Scherer, Denise, Lofters, Aisha, Grunfeld, Eva, Aubrey-Bassler, Kris, Cheung, Heidi, Latko, Katherine, Tink, Wendy, Lewanczuk, Richard, Shea-Budgell, Melissa, Heisey, Ruth, Wong, Tracy, Yang, Huiming, Walji, Sakina, Wilson, Margo, Holmes, Elizabeth, Lang-Robertson, Kelly, DeLonghi, Christina, and Manca, Donna Patricia

Published
2024
Full Text
View/download PDF

2. Hypertension Canada’s 2020 Comprehensive Guidelines for the Prevention, Diagnosis, Risk Assessment, and Treatment of Hypertension in Adults and Children

Author

Rabi, Doreen M., McBrien, Kerry A., Sapir-Pichhadze, Ruth, Nakhla, Meranda, Ahmed, Sofia B., Dumanski, Sandra M., Butalia, Sonia, Leung, Alexander A., Harris, Kevin C., Cloutier, Lyne, Zarnke, Kelly B., Ruzicka, Marcel, Hiremath, Swapnil, Feldman, Ross D., Tobe, Sheldon W., Campbell, Tavis S., Bacon, Simon L., Nerenberg, Kara A., Dresser, George K., Fournier, Anne, Burgess, Ellen, Lindsay, Patrice, Rabkin, Simon W., Prebtani, Ally P.H., Grover, Steven, Honos, George, Alfonsi, Jeffrey E., Arcand, JoAnne, Audibert, François, Benoit, Geneviève, Bittman, Jesse, Bolli, Peter, Côté, Anne-Marie, Dionne, Janis, Don-Wauchope, Andrew, Edwards, Cedric, Firoz, Tabassum, Gabor, Jonathan Y., Gilbert, Richard E., Grégoire, Jean C., Gryn, Steven E., Gupta, Milan, Hannah-Shmouni, Fady, Hegele, Robert A., Herman, Robert J., Hill, Michael D., Howlett, Jonathan G., Hundemer, Gregory L., Jones, Charlotte, Kaczorowski, Janusz, Khan, Nadia A., Kuyper, Laura M., Lamarre-Cliche, Maxime, Lavoie, Kim L., Leiter, Lawrence A., Lewanczuk, Richard, Logan, Alexander G., Magee, Laura A., Mangat, Birinder K., McFarlane, Philip A., McLean, Donna, Michaud, Andre, Milot, Alain, Moe, Gordon W., Penner, S. Brian, Pipe, Andrew, Poppe, Alexandre Y., Rey, Evelyne, Roerecke, Michael, Schiffrin, Ernesto L., Selby, Peter, Sharma, Mike, Shoamanesh, Ashkan, Sivapalan, Praveena, Townsend, Raymond R., Tran, Karen, Trudeau, Luc, Tsuyuki, Ross T., Vallée, Michel, Woo, Vincent, Bell, Alan D., and Daskalopoulou, Stella S.

Published
2020
Full Text
View/download PDF

5. Hypertension Canada’s 2018 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children

Author

Nerenberg, Kara A., Zarnke, Kelly B., Leung, Alexander A., Dasgupta, Kaberi, Butalia, Sonia, McBrien, Kerry, Harris, Kevin C., Nakhla, Meranda, Cloutier, Lyne, Gelfer, Mark, Lamarre-Cliche, Maxime, Milot, Alain, Bolli, Peter, Tremblay, Guy, McLean, Donna, Padwal, Raj S., Tran, Karen C., Grover, Steven, Rabkin, Simon W., Moe, Gordon W., Howlett, Jonathan G., Lindsay, Patrice, Hill, Michael D., Sharma, Mike, Field, Thalia, Wein, Theodore H., Shoamanesh, Ashkan, Dresser, George K., Hamet, Pavel, Herman, Robert J., Burgess, Ellen, Gryn, Steven E., Grégoire, Jean C., Lewanczuk, Richard, Poirier, Luc, Campbell, Tavis S., Feldman, Ross D., Lavoie, Kim L., Tsuyuki, Ross T., Honos, George, Prebtani, Ally P.H., Kline, Gregory, Schiffrin, Ernesto L., Don-Wauchope, Andrew, Tobe, Sheldon W., Gilbert, Richard E., Leiter, Lawrence A., Jones, Charlotte, Woo, Vincent, Hegele, Robert A., Selby, Peter, Pipe, Andrew, McFarlane, Philip A., Oh, Paul, Gupta, Milan, Bacon, Simon L., Kaczorowski, Janusz, Trudeau, Luc, Campbell, Norman R.C., Hiremath, Swapnil, Roerecke, Michael, Arcand, Joanne, Ruzicka, Marcel, Prasad, G.V. Ramesh, Vallée, Michel, Edwards, Cedric, Sivapalan, Praveena, Penner, S. Brian, Fournier, Anne, Benoit, Geneviève, Feber, Janusz, Dionne, Janis, Magee, Laura A., Logan, Alexander G., Côté, Anne-Marie, Rey, Evelyne, Firoz, Tabassum, Kuyper, Laura M., Gabor, Jonathan Y., Townsend, Raymond R., Rabi, Doreen M., and Daskalopoulou, Stella S.

Published
2018
Full Text
View/download PDF

6. Tolerability of bedtime diuretics: a prospective cohort analysis

Author

Garrison, Scott R, primary, Kelmer, Michael, additional, Korownyk, Tina, additional, Kolber, Michael R, additional, Allan, Gary Michael, additional, Bakal, Jeffrey, additional, Singer, Alexander, additional, Katz, Alan, additional, Mcalister, Finlay, additional, Padwal, Raj S, additional, Lewanczuk, Richard, additional, Hill, Michael D, additional, McGrail, Kimberlyn, additional, O’Neill, Braden, additional, Greiver, Michelle, additional, Manca, Donna P, additional, Mangin, Dee, additional, Wong, Sabrina T, additional, Kirkwood, Jessica E M, additional, McCormack, James P, additional, Yeung, Jack M S, additional, and Green, Lee, additional

Published
2023
Full Text
View/download PDF

7. Hypertension Canada's 2017 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults

Author

Leung, Alexander A., Daskalopoulou, Stella S., Dasgupta, Kaberi, McBrien, Kerry, Butalia, Sonia, Zarnke, Kelly B., Nerenberg, Kara, Harris, Kevin C., Nakhla, Meranda, Cloutier, Lyne, Gelfer, Mark, Lamarre-Cliche, Maxime, Milot, Alain, Bolli, Peter, Tremblay, Guy, McLean, Donna, Tobe, Sheldon W., Ruzicka, Marcel, Burns, Kevin D., Vallée, Michel, Prasad, G.V. Ramesh, Gryn, Steven E., Feldman, Ross D., Selby, Peter, Pipe, Andrew, Schiffrin, Ernesto L., McFarlane, Philip A., Oh, Paul, Hegele, Robert A., Khara, Milan, Wilson, Thomas W., Penner, S. Brian, Burgess, Ellen, Sivapalan, Praveena, Herman, Robert J., Bacon, Simon L., Rabkin, Simon W., Gilbert, Richard E., Campbell, Tavis S., Grover, Steven, Honos, George, Lindsay, Patrice, Hill, Michael D., Coutts, Shelagh B., Gubitz, Gord, Campbell, Norman R.C., Moe, Gordon W., Howlett, Jonathan G., Boulanger, Jean-Martin, Prebtani, Ally, Kline, Gregory, Leiter, Lawrence A., Jones, Charlotte, Côté, Anne-Marie, Woo, Vincent, Kaczorowski, Janusz, Trudeau, Luc, Tsuyuki, Ross T., Hiremath, Swapnil, Drouin, Denis, Lavoie, Kim L., Hamet, Pavel, Grégoire, Jean C., Lewanczuk, Richard, Dresser, George K., Sharma, Mukul, Reid, Debra, Lear, Scott A., Moullec, Gregory, Gupta, Milan, Magee, Laura A., Logan, Alexander G., Dionne, Janis, Fournier, Anne, Benoit, Geneviève, Feber, Janusz, Poirier, Luc, Padwal, Raj S., and Rabi, Doreen M.

Published
2017
Full Text
View/download PDF

10. Hypertension Canada's 2016 Canadian Hypertension Education Program Guidelines for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension

Author

Leung, Alexander A., Nerenberg, Kara, Daskalopoulou, Stella S., McBrien, Kerry, Zarnke, Kelly B., Dasgupta, Kaberi, Cloutier, Lyne, Gelfer, Mark, Lamarre-Cliche, Maxime, Milot, Alain, Bolli, Peter, Tremblay, Guy, McLean, Donna, Tobe, Sheldon W., Ruzicka, Marcel, Burns, Kevin D., Vallée, Michel, Prasad, G.V. Ramesh, Lebel, Marcel, Feldman, Ross D., Selby, Peter, Pipe, Andrew, Schiffrin, Ernesto L., McFarlane, Philip A., Oh, Paul, Hegele, Robert A., Khara, Milan, Wilson, Thomas W., Penner, S. Brian, Burgess, Ellen, Herman, Robert J., Bacon, Simon L., Rabkin, Simon W., Gilbert, Richard E., Campbell, Tavis S., Grover, Steven, Honos, George, Lindsay, Patrice, Hill, Michael D., Coutts, Shelagh B., Gubitz, Gord, Campbell, Norman R.C., Moe, Gordon W., Howlett, Jonathan G., Boulanger, Jean-Martin, Prebtani, Ally, Larochelle, Pierre, Leiter, Lawrence A., Jones, Charlotte, Ogilvie, Richard I., Woo, Vincent, Kaczorowski, Janusz, Trudeau, Luc, Petrella, Robert J., Hiremath, Swapnil, Drouin, Denis, Lavoie, Kim L., Hamet, Pavel, Fodor, George, Grégoire, Jean C., Lewanczuk, Richard, Dresser, George K., Sharma, Mukul, Reid, Debra, Lear, Scott A., Moullec, Gregory, Gupta, Milan, Magee, Laura A., Logan, Alexander G., Harris, Kevin C., Dionne, Janis, Fournier, Anne, Benoit, Geneviève, Feber, Janusz, Poirier, Luc, Padwal, Raj S., and Rabi, Doreen M.

Published
2016
Full Text
View/download PDF

13. The 2015 Canadian Hypertension Education Program Recommendations for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension

Author

Daskalopoulou, Stella S., Rabi, Doreen M., Zarnke, Kelly B., Dasgupta, Kaberi, Nerenberg, Kara, Cloutier, Lyne, Gelfer, Mark, Lamarre-Cliche, Maxime, Milot, Alain, Bolli, Peter, McKay, Donald W., Tremblay, Guy, McLean, Donna, Tobe, Sheldon W., Ruzicka, Marcel, Burns, Kevin D., Vallée, Michel, Ramesh Prasad, G.V., Lebel, Marcel, Feldman, Ross D., Selby, Peter, Pipe, Andrew, Schiffrin, Ernesto L., McFarlane, Philip A., Oh, Paul, Hegele, Robert A., Khara, Milan, Wilson, Thomas W., Brian Penner, S., Burgess, Ellen, Herman, Robert J., Bacon, Simon L., Rabkin, Simon W., Gilbert, Richard E., Campbell, Tavis S., Grover, Steven, Honos, George, Lindsay, Patrice, Hill, Michael D., Coutts, Shelagh B., Gubitz, Gord, Campbell, Norman R.C., Moe, Gordon W., Howlett, Jonathan G., Boulanger, Jean-Martin, Prebtani, Ally, Larochelle, Pierre, Leiter, Lawrence A., Jones, Charlotte, Ogilvie, Richard I., Woo, Vincent, Kaczorowski, Janusz, Trudeau, Luc, Petrella, Robert J., Hiremath, Swapnil, Stone, James A., Drouin, Denis, Lavoie, Kim L., Hamet, Pavel, Fodor, George, Grégoire, Jean C., Fournier, Anne, Lewanczuk, Richard, Dresser, George K., Sharma, Mukul, Reid, Debra, Benoit, Geneviève, Feber, Janusz, Harris, Kevin C., Poirier, Luc, and Padwal, Raj S.

Published
2015
Full Text
View/download PDF

15. The effect of provider affiliation with a primary care network on emergency department visits and hospital admissions

Author

McAlister, Finlay A., Bakal, Jeffrey A., Green, Lee, Bahler, Brad, and Lewanczuk, Richard

Subjects
Hospital emergency services -- Statistics, Hospital admission and discharge -- Statistics, Treatment outcome -- Comparative analysis, Primary health care -- Influence -- Statistics, Health
Abstract

BACKGROUND: Primary care networks are designed to facilitate access to inter-professional, team-based care. We compared health outcomes associated with primary care networks versus conventional primary care. METHODS: We obtained data on all adult residents of Alberta who visited a primary care physician during fiscal years 2008 and 2009 and classified them as affiliated with a primary care network or not, based on the physician most involved in their care. The primary outcome was an emergency department visit or nonelective hospital admission for a Patient Medical Home indicator condition (asthma, chronic obstructive pulmonary disease, heart failure, coronary disease, hypertension and diabetes) within 12 months. RESULTS: Adults receiving care within a primary care network (n = 1502916) were older and had higher comorbidity burdens than those receiving conventional primary care (n = 1109941). Patients in a primary care network were less likely to visit the emergency department for an indicator condition (1.4% v. 1.7%, mean 0.031 v. 0.035 per patient, adjusted risk ratio [RR] 0.98, 95% confidence interval [CI] 0.96-0.99) or for any cause (25.5% v. 30.5%, mean 0.55 v. 0.72 per patient, adjusted RR 0.93, 95% CI 0.93-0.94), but were more likely to be admitted to hospital for an indicator condition (0.6% v. 0.6%, mean 0.018 v. 0.017 per patient, adjusted RR 1.07, 95% CI 1.03-1.11) or all-cause (9.3% v. 9.1%, mean 0.25 v. 0.23 per patient, adjusted RR 1.08, 95% CI 1.07-1.09). Patients in a primary care network had 169 fewer all-cause emergency department visits and 86 fewer days in hospital (owing to shorter lengths of stay) per 1000 patient-years. INTERPRETATION: Care within a primary care network was associated with fewer emergency department visits and fewer hospital days., In Alberta, primary care networks were established in 2005 to help facilitate both access to primary care and adoption of the Patient Medical Home model of care, which focuses on [...]

Published
2018
Full Text
View/download PDF

20. Healthy food prescription incentive programme for adults with type 2 diabetes who are experiencing food insecurity: protocol for a randomised controlled trial, modelling and implementation studies

Author

Olstad, Dana Lee, primary, Beall, Reed, additional, Spackman, Eldon, additional, Dunn, Sharlette, additional, Lipscombe, Lorraine L, additional, Williams, Kienan, additional, Oster, Richard, additional, Scott, Sara, additional, Zimmermann, Gabrielle L, additional, McBrien, Kerry A, additional, Steer, Kieran J D, additional, Chan, Catherine B, additional, Tyminski, Sheila, additional, Berkowitz, Seth, additional, Edwards, Alun L, additional, Saunders-Smith, Terry, additional, Tariq, Saania, additional, Popeski, Naomi, additional, White, Laura, additional, Williamson, Tyler, additional, L'Abbé, Mary, additional, Raine, Kim D, additional, Nejatinamini, Sara, additional, Naser, Aruba, additional, Basualdo-Hammond, Carlota, additional, Norris, Colleen, additional, O’Connell, Petra, additional, Seidel, Judy, additional, Lewanczuk, Richard, additional, Cabaj, Jason, additional, and Campbell, David J T, additional

Published
2022
Full Text
View/download PDF

21. The 2011 Canadian Hypertension Education Program Recommendations for the Management of Hypertension: Blood Pressure Measurement, Diagnosis, Assessment of Risk, and Therapy

Author

Rabi, Doreen M., Daskalopoulou, Stella S., Padwal, Raj S., Khan, Nadia A., Grover, Steven A., Hackam, Daniel G., Myers, Martin G., McKay, Donald W., Quinn, Robert R., Hemmelgarn, Brenda R., Cloutier, Lyne, Bolli, Peter, Hill, Michael D., Wilson, Thomas, Penner, Brian, Burgess, Ellen, Lamarre-Cliché, Maxime, McLean, Donna, Schiffrin, Ernesto L., Honos, George, Mann, Karen, Tremblay, Guy, Milot, Alain, Chockalingam, Arun, Rabkin, Simon W., Dawes, Martin, Touyz, Rhian M., Burns, Kevin D., Ruzicka, Marcel, Campbell, Norman R.C., Vallée, Michel, Prasad, G.V. Ramesh, Lebel, Marcel, Campbell, Tavis S., Lindsay, M. Patrice, Herman, Robert J., Larochelle, Pierre, Feldman, Ross D., Arnold, J. Malcolm O., Moe, Gordon W., Howlett, Jonathan G., Trudeau, Luc, Bacon, Simon L., Petrella, Robert J., Lewanczuk, Richard, Stone, James A., Drouin, Denis, Boulanger, Jean-Martin, Sharma, Mukul, Hamet, Pavel, Fodor, George, Dresser, George K., Carruthers, S. George, Pylypchuk, George, Gilbert, Richard E., Leiter, Lawrence A., Jones, Charlotte, Ogilvie, Richard I., Woo, Vincent, McFarlane, Philip A., Hegele, Robert A., Poirier, Luc, and Tobe, Sheldon W.

Published
2011
Full Text
View/download PDF

22. Identification and Management of Cardiometabolic Risk in Canada: A Position Paper by the Cardiometabolic Risk Working Group (Executive Summary)

Author

Leiter, Lawrence A., Fitchett, David H., Gilbert, Richard E., Gupta, Milan, Mancini, G.B. John, McFarlane, Philip A., Ross, Robert, Teoh, Hwee, Verma, Subodh, Anand, Sonia, Camelon, Kathryn, Chow, Chi-Ming, Cox, Jafna L., Després, Jean-Pierre, Genest, Jacques, Harris, Stewart B., Lau, David C.W., Lewanczuk, Richard, Liu, Peter P., Lonn, Eva M., McPherson, Ruth, Poirier, Paul, Qaadri, Shafiq, Rabasa-Lhoret, Rémi, Rabkin, Simon W., Sharma, Arya M., Steele, Andrew W., Stone, James A., Tardif, Jean-Claude, Tobe, Sheldon, and Ur, Ehud

Published
2011
Full Text
View/download PDF

23. Cardiometabolic Risk in Canada: A Detailed Analysis and Position Paper by the Cardiometabolic Risk Working Group

Author

Leiter, Lawrence A., Fitchett, David H., Gilbert, Richard E., Gupta, Milan, Mancini, G.B. John, McFarlane, Philip A., Ross, Robert, Teoh, Hwee, Verma, Subodh, Anand, Sonia, Camelon, Kathryn, Chow, Chi-Ming, Cox, Jafna L., Després, Jean-Pierre, Genest, Jacques, Harris, Stewart B., Lau, David C.W., Lewanczuk, Richard, Liu, Peter P., Lonn, Eva M., McPherson, Ruth, Poirier, Paul, Qaadri, Shafiq, Rabasa-Lhoret, Rémi, Rabkin, Simon W., Sharma, Arya M., Steele, Andrew W., Stone, James A., Tardif, Jean-Claude, Tobe, Sheldon, and Ur, Ehud

Published
2011
Full Text
View/download PDF

30. The 2009 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 2 – therapy

Author

Khan, Nadia A., Hemmelgarn, Brenda, Herman, Robert J., Bell, Chaim M., Mahon, Jeff L., Leiter, Lawrence A., Rabkin, Simon W., Hill, Michael D., Padwal, Raj, Touyz, Rhian M., Larochelle, Pierre, Feldman, Ross D., Schiffrin, Ernesto L., Campbell, Norman R.C., Moe, Gordon, Prasad, Ramesh, Arnold, Malcolm O., Campbell, Tavis S., Milot, Alain, Stone, James A., Jones, Charlotte, Ogilvie, Richard I., Hamet, Pavel, Fodor, George, Carruthers, George, Burns, Kevin D., Ruzicka, Marcel, deChamplain, Jacques, Pylypchuk, George, Petrella, Robert, Boulanger, Jean-Martin, Trudeau, Luc, Hegele, Robert A., Woo, Vincent, McFarlane, Phil, Vallée, Michel, Howlett, Jonathan, Bacon, Simon L., Lindsay, Patrice, Gilbert, Richard E., Lewanczuk, Richard Z., and Tobe, Sheldon

Published
2009
Full Text
View/download PDF

34. The 2008 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 2 – therapy

Author

Khan, Nadia A., Hemmelgarn, Brenda, Herman, Robert J., Rabkin, Simon W., McAlister, Finlay A., Bell, Chaim M., Touyz, Rhian M., Padwal, Raj, Leiter, Lawrence A., Mahon, Jeff L., Hill, Michael D., Larochelle, Pierre, Feldman, Ross D., Schiffrin, Ernesto L., Campbell, Norman R.C., Arnold, Malcolm O., Moe, Gordon, Campbell, Tavis S., Milot, Alain, Stone, James A., Jones, Charlotte, Ogilvie, Richard I., Hamet, Pavel, Fodor, George, Carruthers, George, Burns, Kevin D., Ruzicka, Marcel, deChamplain, Jacques, Pylypchuk, George, Petrella, Robert, Boulanger, Jean-Martin, Trudeau, Luc, Hegele, Robert A., Woo, Vincent, McFarlane, Phil, Vallée, Michel, Howlett, Jonathan, Katzmarzyk, Peter, Tobe, Sheldon, and Lewanczuk, Richard Z.

Published
2008
Full Text
View/download PDF

38. The 2007 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 2 – therapy

Author

Khan, Nadia A., Hemmelgarn, Brenda, Padwal, Raj, Larochelle, Pierre, Mahon, Jeff L., Lewanczuk, Richard Z., McAlister, Finlay A., Rabkin, Simon W., Hill, Michael D, Feldman, Ross D., Schiffrin, Ernesto L., Campbell, Norman R.C., Logan, Alexander G., Arnold, Malcolm, Moe, Gordon, Campbell, Tavis S., Milot, Alain, Stone, James A., Jones, Charlotte, Leiter, Lawrence A., Ogilvie, Richard I., Herman, Robert J., Hamet, Pavel, Fodor, George, Carruthers, George, Culleton, Bruce, Burns, Kevin D., Ruzicka, Marcel, deChamplain, Jacques, Pylypchuk, George, Gledhill, Norm, Petrella, Robert, Boulanger, Jean-Martin, Trudeau, Luc, Hegele, Robert A., Woo, Vincent, McFarlane, Phil, Touyz, Rhian M., and Tobe, Sheldon W.

Published
2007
Full Text
View/download PDF

39. Drug-disease interactions: losartan effect is not downregulated by rheumatoid arthritis

Author

Daneshtalab, Noriko, Lewanczuk, Richard Z., Russell, Anthony S., and Jamali, Fakhreddin

Subjects
Losartan -- Health aspects -- Research, Drug interactions -- Research -- Health aspects, Rheumatoid arthritis -- Health aspects -- Research, Health, Research, Health aspects
Abstract

Inflammatory conditions, such as rheumatoid arthritis, reduce response to calcium channel and β-adrenergic antagonists but not the angiotensin II type 1 receptor ([AT.sub.1]R) antagonist valsartan. Inflammation also reduces clearance of [...]

Published
2006

40. HCaRG is a novel regulator of renal epithelial cell growth and differentiation causing [G.sub.2]M arrest

Author

Devlin, Alison M., Solban, Nicolas, Tremblay, Sandra, Gutkowska, Jolanta, Schurch, Walter, Orlov, Sergei N., Lewanczuk, Richard, Hamet, Pavel, and Tremblay, Johanne

Subjects
Physiology -- Research, Natriuretic peptides -- Physiological aspects, Biological sciences
Abstract

We recently identified a novel calcium-regulated gene, HCaRG, that is highly expressed in the kidney and maps to a chromosomal locus determining kidney weight in rats. The mRNA levels of HCaRG negatively correlate with the proliferative status of the kidney cells. To investigate its role in renal epithelial cellular growth directly, we studied the human embryonic kidney cell line (HEK-293) stably transfected with either plasmid alone or plasmid containing rat HCaRG. [[sup.3]H]thymidine incorporation was significantly lower in HCaRG clones. Although HCaRG clones exhibited some enhanced susceptibility to cell death, this was not the primary mechanism of reduced proliferation. Cell cycle analysis revealed a [G.sub.2]M phase accumulation in HCaRG clones that was associated with upregulation of p[21.sup.Cip1/WAF1] and downregulation of p[27.sup.Kip1]. HCaRG clones had a greater protein content, larger cell size, and re]eased 4.5- to 8-fold more of an atrial natriuretic peptide-like immunoreactivity compared with controls. In addition, HCaRG clones demonstrated the presence of differentiated junctions and a lower incidence of mitotic figures. Genistein treatment of wild-type HEK-293 cells mimicked several phenotypic characteristics associated with HCaRG overexpresssion, including increased cell size and increased release of atrial natriuretic peptide. Taken together, our results suggest that HCaRG is a regulator of renal epithelial cell growth and differentiation causing [G.sub.2]M cell cycle arrest. novel gene; p[21.sup.Cip/WAF1; p[27.sup.Kip1]; atrial natriuretic peptide; human embryonic kidney 293 cells; hypertension-related, calcium-regulated gene

Published
2003

41. Physical Activity Intensity and Cardiometabolic Risk in Youth

Author

Hay, Jacqueline, Maximova, Katerina, Durksen, Anita, Carson, Valerie, Rinaldi, Randi Lynn, Torrance, Brian, Ball, Geoff D., Majumdar, Sumit R., Plotnikoff, Ronald C., Veugelers, Paul, Boulé, Normand G., Wozny, Paul, McCargar, Linda, Downs, Shauna, Lewanczuk, Richard, and McGavock, Jonathan

Published
2012
Full Text
View/download PDF

43. The 2006 Canadian Hypertension Education Program recommendations for the management of hypertension: Part II – Therapy

Author

Khan, Nadia A., McAlister, Finlay A., Rabkin, Simon W., Padwal, Raj, Feldman, Ross D., Campbell, Norman R.C., Leiter, Lawrence A., Lewanczuk, Richard Z., Schiffrin, Ernesto L., Hill, Michael D., Arnold, Malcolm, Moe, Gordon, Campbell, Tavis S., Herbert, Carol, Milot, Alain, Stone, James A., Burgess, Ellen, Hemmelgarn, B., Jones, Charlotte, Larochelle, Pierre, Ogilvie, Richard I., Houlden, Robyn, Herman, Robert J., Hamet, Pavel, Fodor, George, Carruthers, George, Culleton, Bruce, deChamplain, Jacques, Pylypchuk, George, Logan, Alexander G., Gledhill, Norm, Petrella, Robert, Tobe, Sheldon, and Touyz, Rhian M.

Published
2006
Full Text
View/download PDF

49. Association between continuity and access in primary care: a retrospective cohort study

Author

Cook, Lisa L., primary, Golonka, Richard P., additional, Cook, Charles M., additional, Walker, Robin L., additional, Faris, Peter, additional, Spenceley, Shannon, additional, Lewanczuk, Richard, additional, Wedel, Robert, additional, Love, Rebecca, additional, Andres, Cheryl, additional, Byers, Susan D., additional, Collins, Tim, additional, and Oddie, Scott, additional

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results