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29 results on '"Leukemia -- Genetic aspects -- Care and treatment"'

1. Findings from Peter MacCallum Cancer Centre in Gene Therapy Reported (RNA kinetics influence the response to transcriptional perturbation in leukaemia cell lines)

Subjects
Medical research, Medicine, Experimental, Genetic research -- Genetic aspects, Genes -- Genetic aspects, Leukemia -- Genetic aspects -- Care and treatment, Gene therapy, Cancer -- Care and treatment -- Genetic aspects, RNA -- Genetic aspects, Genetic transcription -- Genetic aspects, Business, Health, Health care industry
Abstract

2024 OCT 22 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Weekly -- Researchers detail new data in gene therapy. According to news originating from the Peter MacCallum [...]

Published
2024

2. Researchers from Fred Hutchinson Cancer Research Center Report New Studies and Findings in the Area of Cancer Gene Therapy (Ha-1-targeted T-cell Receptor T-cell Therapy for Recurrent Leukemia After Hematopoietic Stem Cell Transplantation)

Subjects
United States. National Cancer Institute -- Reports, Oncology, Experimental -- Health aspects -- Reports -- Genetic aspects, T cells -- Genetic aspects -- Reports -- Health aspects, Antineoplastic agents -- Reports -- Health aspects, Genes -- Reports -- Genetic aspects -- Health aspects, Leukemia -- Genetic aspects -- Care and treatment, Diseases -- Relapse, Stem cells -- Reports -- Genetic aspects -- Health aspects, Gene therapy -- Reports -- Health aspects, Hematopoietic stem cells -- Transplantation, Cancer -- Genetic aspects -- Research, Antimitotic agents -- Reports -- Health aspects, Health, Fred Hutchinson Cancer Research Center -- Reports
Abstract

2024 OCT 14 (NewsRx) -- By a News Reporter-Staff News Editor at Hematology Week -- Current study results on Biotechnology - Cancer Gene Therapy have been published. According to news [...]

Published
2024

3. Size matters in telomere biology disorders - expanding phenotypic spectrum in patients with long or short telomeres

Author

Byrjalsen, Anna, Brainin, Anna Engell, Lund, Thomas Kromann, Andersen, Mette Klarskov, and Jelsig, Anne Marie

Subjects
Nucleotide sequencing -- Genetic aspects, Leukemia -- Genetic aspects -- Care and treatment, DNA sequencing -- Genetic aspects, Telomeres -- Genetic aspects, Health
Abstract

The end of each chromosome consists of a DNA region termed the telomeres. The telomeres serve as a protective shield against degradation of the coding DNA sequence, as the DNA strand inevitably - with each cell division - is shortened. Inherited genetic variants cause telomere biology disorders when located in genes (e.g. DKC1, RTEL1, TERC, TERT) playing a role in the function and maintenance of the telomeres. Subsequently patients with telomere biology disorders associated with both too short or too long telomeres have been recognized. Patients with telomere biology disorders associated with short telomeres are at increased risk of dyskeratosis congenita (nail dystrophy, oral leukoplakia, and hyper- or hypo-pigmentation of the skin), pulmonary fibrosis, hematologic disease (ranging from cytopenia to leukemia) and in rare cases very severe multiorgan manifestations and early death. Patients with telomere biology disorders associated with too long telomeres have in recent years been found to confer an increased risk of melanoma and chronic lymphocytic leukemia. Despite this, many patients have an apparently isolated manifestation rendering telomere biology disorders most likely underdiagnosed. The complexity of telomere biology disorders and many causative genes makes it difficult to design a surveillance program which will ensure identification of early onset disease manifestation without overtreatment. Keywords: Telomere biology disorders, Lung fibrosis, Cancer predisposition, Long telomeres, Short telomeres, Author(s): Anna Byrjalsen[sup.1], Anna Engell Brainin[sup.1], Thomas Kromann Lund[sup.2], Mette Klarskov Andersen[sup.1] and Anne Marie Jelsig[sup.1] Introduction Telomere Biology Disorders (TBD) comprise a group of inherited disorders characterized by a [...]

Published
2023
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4. Researcher at Fred Hutchinson Cancer Research Center Has Published New Data on Cancer Gene Therapy [HA-1-targeted T cell receptor (TCR) T cell therapy for recurrent leukemia after hematopoietic stem cell transplantation]

Subjects
Oncology, Experimental -- Reports -- Genetic aspects, T cells -- Genetic aspects -- Reports, Antineoplastic agents -- Reports, Genes -- Reports -- Genetic aspects, Leukemia -- Genetic aspects -- Care and treatment, Diseases -- Relapse, Stem cells -- Reports -- Genetic aspects, Gene therapy -- Reports, Hematopoietic stem cells -- Transplantation, Cancer -- Genetic aspects -- Research, Antimitotic agents -- Reports, Health, Fred Hutchinson Cancer Research Center -- Reports
Abstract

2024 MAY 13 (NewsRx) -- By a News Reporter-Staff News Editor at Hematology Week -- Fresh data on cancer gene therapy are presented in a new report. According to news [...]

Published
2024

5. CITY OF HOPE RESEARCH FEATURING THE SUCCESSFUL TREATMENT OF THE OLDEST PATIENT TO ACHIEVE REMISSION FOR LEUKEMIA AND HIV PUBLISHED IN THE NEW ENGLAND JOURNAL OF MEDICINE (NEJM)

Subjects
Oncology, Experimental -- Health aspects -- Genetic aspects, Gene mutations -- Health aspects -- Genetic aspects, HIV (Viruses) -- Care and treatment -- Genetic aspects, Aged -- Health aspects, Leukemia -- Genetic aspects -- Care and treatment, Hematopoietic stem cells -- Transplantation -- Health aspects, Chemotherapy -- Health aspects, Cancer -- Chemotherapy -- Research, Stem cell research -- Health aspects -- Genetic aspects, HIV infection -- Care and treatment -- Genetic aspects, News, opinion and commentary
Abstract

LOS ANGELES -- The following information was released by City of Hope: City of Hope®, one of the largest cancer research and treatment organizations in the United States, treated the [...]

Published
2024

6. Research Findings from National Cancer Center Research Institute Update Understanding of Fanconi Anemia (Genetic Landscape of Myeloid Neoplasms in Patients With Fanconi Anemia)

Subjects
Oncology, Experimental -- Genetic aspects, Leukemia -- Genetic aspects -- Care and treatment, Fanconi's anemia -- Care and treatment -- Genetic aspects, Cancer -- Research, Health
Abstract

2024 MAR 29 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- A new study on fanconi anemia is now available. According to news reporting [...]

Published
2024

7. Temple University School of Medicine Researcher Discusses Research in Leukemia (DNA polymerase theta protects leukemia cells from metabolic-induced DNA damage)

Subjects
Oncology, Experimental, DNA repair -- Research, Metabolism -- Genetic aspects -- Health aspects, Leukemia -- Genetic aspects -- Care and treatment, DNA damage -- Research, Cancer cells -- Genetic aspects -- Physiological aspects, Cancer -- Research, DNA polymerases -- Health aspects -- Physiological aspects, Health
Abstract

2023 JAN 21 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Fresh data on leukemia are presented in a new report. According to [...]

Published
2023

8. Data on Leukemia Detailed by Researchers at Chang Gung Memorial Hospital (Hoxa11-mediated Reduction of Cell Migration Contributes To Myeloid Sarcoma Formation Induced By Cooperation of Mll/af10 With Activating Kras Mutation In a Mouse ...)

Subjects
Gene mutations -- Health aspects, Sarcoma -- Genetic aspects -- Care and treatment, Leukemia -- Genetic aspects -- Care and treatment, Health
Abstract

2022 JUL 9 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on Oncology - Leukemia have been published. According to [...]

Published
2022

9. CRUCIAL LLS SUPPORT DRIVES APPROVAL OF NEW PRECISION MEDICINE FOR RARE GROUP OF BLOOD DISEASES

Subjects
United States. Food and Drug Administration, Leukemia -- Genetic aspects -- Care and treatment, Blood diseases -- Genetic aspects -- Care and treatment, Drug approval, News, opinion and commentary
Abstract

WHITE PLAINS, NY -- The following information was released by the Leukemia & Lymphoma Society: Crucial LLS Support Drives Approval of New Precision Medicine for Rare Group of Blood Diseases [...]

Published
2022

10. Ten Years After Gene Therapy for Leukemia, Doctors Say Patients Cured

Author

Foster, Robin

Subjects
The Associated Press -- Officials and employees, T cells -- Genetic aspects -- Reports, Genes -- Reports -- Genetic aspects, Antineoplastic agents -- Reports, Leukemia -- Genetic aspects -- Care and treatment, News agencies -- Officials and employees, Gene therapy -- Reports, Cancer -- Care and treatment -- Genetic aspects, Antimitotic agents -- Reports, News, opinion and commentary, Sports and fitness
Abstract

Byline: Robin Foster TUESDAY, Feb. 2, 2022 (HealthDay News) -- More than 10 years after Doug Olsen underwent an experimental gene therapy that turned his T-cells into cancer killers, his [...]

Published
2022

11. HDAC3 is essential for DNA replication in hematopoietic progenitor cells

Author

Summers, Alyssa R., Fischer, Melissa A., Stengel, Kristy R., Zhao, Yue, Kaiser, Jonathan F., Wells, Christina E., Hunt, Aubrey, Bhaskara, Srividya, Luzwick, Jessica W., Sampathi, Shilpa, Chen, Xi, Thompson, Mary Ann, Cortez, David, and Hiebert, Scott W.

Subjects
Gene expression -- Physiological aspects -- Analysis -- Health aspects, DNA replication -- Physiological aspects -- Analysis, Leukemia -- Genetic aspects -- Care and treatment, Lymphomas -- Genetic aspects -- Care and treatment, Genetic engineering -- Health aspects, Health care industry
Abstract

Histone deacetylase 3 (HDAC3) contributes to the regulation of gene expression, chromatin structure, and genomic stability. Because HDAC3 associates with oncoproteins that drive leukemia and lymphoma, we engineered a conditional [...]

Published
2013
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12. NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human

Author

Yu, Jianhua, Mitsui, Takeki, Wei, Min, Mao, Hsiaoyin, Butchar, Jonathan P., Shah, Mithun Vinod, Zhang, Jianying, Mishra, Anjali, Alvarez-Breckenridge, Christopher, Liu, Xingluo, Liu, Shujun, Yokohama, Akihiko, Trotta, Rossana, Marcucci, Guido, Benson, Jr., Don M., Loughran, Jr., Thomas P., Tridandapani, Susheela, and Caligiuri, Michael A.

Subjects
T cells -- Health aspects, Gene expression -- Research, Leukemia -- Genetic aspects -- Care and treatment, Health care industry
Abstract

IL-15 may have a role in the development of T cell large granular lymphocyte (T-LGL) or NKT leukemias. However, the mechanisms of action and the identity of the cell subset that undergoes leukemic transformation remain elusive. Here we show that in both mice and humans, NKp46 expression marks a minute population of WT NKT cells with higher activity and potency to become leukemic. Virtually 100% of T-LGL leukemias in IL-15 transgenic mice expressed NKp46, as did a majority of human T-LGL leukemias. The minute [NKp46.sup.+] NKT population, but not the NKp46 NKT population, was selectively expanded by overexpression of endogenous IL-15. Importantly, IL-15 transgenic NKp46 NKT cells did not become [NKp46.sup.+] in vivo, suggesting that [NKp46.sup.+] T-LGL leukemia cells were the malignant counterpart of the minute WT [NKp46.sup.+] NKT population. Mechanistically, [NKp46.sup.+] NKT cells possessed higher responsiveness to IL-15 in vitro and in vivo compared with that of their NKp46 NKT counterparts. Furthermore, interruption of IL-15 signaling using a neutralizing antibody could prevent LGL leukemia in IL-15 transgenic mice. Collectively, our data demonstrate that NKp46 identifies a functionally distinct NKT subset in mice and humans that appears to be directly susceptible to leukemic transformation when IL-15 is overexpressed. Thus, IL-15 signaling and NKp46 maybe useful targets in the treatment of patients with T-LGL or NKT leukemia., Introduction NKT cells are defined as a subset of T cells that share some characteristics with NK cells, particularly expression of the NK1.1 or DX5 antigen in mice and CD56 [...]

Published
2011
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13. Some leukemia patients may be missing out on new treatments

Subjects
Physical fitness, Leukemia -- Genetic aspects -- Care and treatment, Drug approval, Biological markers, Health, University of London
Abstract

2018 JAN 27 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Patients with an aggressive form of leukaemia, currently ineligible for any type [...]

Published
2018

14. Written in blood: technologies that rapidly sequence DNA reveal deep genetic diversity both within and among individuals with leukaemia

Author

Deweerdt, Sarah

Subjects
Nucleotide sequencing -- Research, Leukemia -- Genetic aspects -- Care and treatment, DNA sequencing -- Research, Cancer -- Care and treatment, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

In 1959, David Hungerford of the Fox Chase Cancer Center and Peter Nowell from the University of Pennsylvania School of Medicine discovered that blood cells taken from two people with [...]

Published
2013

15. Racing to Alter Patients' Cells To Kill Cancer

Author

Grady, Denise

Subjects
Cancer treatment -- Research, White blood cells -- Analysis, Gene therapy -- Research -- Complications and side effects, Leukemia -- Genetic aspects -- Care and treatment, General interest, News, opinion and commentary
Abstract

The approval of gene therapy for leukemia, expected in the next few months, will open the door to a radically new class of cancer treatments. Companies and universities are racing [...]

Published
2017

16. Cellestia Biotech AG Cellestia starts first-in-human Phase I-lla study

Subjects
Clinical trials, Biotechnology, Transcription (Genetics), Leukemia -- Genetic aspects -- Care and treatment, Lymphomas -- Genetic aspects -- Care and treatment, General interest, News, opinion and commentary
Abstract

London: Cellestia Biotech AG has issued the following news release: Cellestia announces today the successful first dosing of cancer patients has started in December 2017 with the lead compound CB-103 [...]

Published
2018

17. Alliance for Cancer Gene Therapy Announces New CEO and President

Subjects
Cancer treatment, Chief executive officers, Gene therapy, Genes, Leukemia -- Genetic aspects -- Care and treatment, Associations, Business, Business, international
Abstract

John Walter to Lead Nonprofit Into Next Chapter with Major Focus on Treating Cancer and Forging Partnerships STAMFORD, Conn. -- Alliance for Cancer Gene Therapy (ACGT) , the nation's only [...]

Published
2016

18. Gene therapy cures adult leukemia patient in China

Subjects
Cancer treatment, Cancer genetics -- Genetic aspects -- Care and treatment, Gene therapy, Genes, Leukemia -- Genetic aspects -- Care and treatment, Antineoplastic agents, Business, general, General interest, News, opinion and commentary
Abstract

CHONGQING, Dec 04, 2015 (Xinhua via COMTEX) -- Chinese doctors have cured a patient of leukemia using gene therapy, a hospital in Chongqing announced Friday. Zhang Fang, a middle-aged woman, [...]

Published
2015

19. Gene editing helps baby battle cancer: T cells get tweaked to target leukemia but not harm the patient

Author

Saey, Tina Hesman

Subjects
Human genetic engineering -- Health aspects, Cancer genetics, Leukemia -- Genetic aspects -- Care and treatment, T cells -- Health aspects, Science and technology
Abstract

Molecular scalpels that slice genes helped push a 1-year-old girl's leukemia into remission, doctors announced November 5 at a news briefing. A medical team at the Great Ormond Street Hospital [...]

Published
2015

20. University of Pennsylvania gene therapy shows promise in eradicating some blood cancers

Subjects
T cells, Genes, Leukemia -- Genetic aspects -- Care and treatment, Gene therapy, Cancer -- Care and treatment -- Genetic aspects, Universities and colleges -- Pennsylvania, Business, General interest, Business, regional, Actemra (Medication)
Abstract

Byline: Marie McCullough Dec. 10--A 7-year-old pixie named Emily Whitehead has erased any remaining doubts about the power of a University of Pennsylvania gene therapy to eradicate certain blood cancers. [...]

Published
2012

21. Gene therapy shows promise in eradicating blood cancers

Subjects
T cells, Genes, Leukemia -- Genetic aspects -- Care and treatment, Gene therapy, Cancer -- Care and treatment -- Genetic aspects, Business, General interest, Business, regional, Actemra (Medication)
Abstract

Byline: Marie McCullough Dec. 10--A 7-year-old pixie named Emily Whitehead has erased any remaining doubts about the power of a University of Pennsylvania gene therapy to eradicate certain blood cancers. [...]

Published
2012

22. New Leukemia Gene Therapy Data Have Been Reported by M. Cianfriglia and Co-Authors

Subjects
Biological products, Antineoplastic agents, Leukemia -- Genetic aspects -- Care and treatment, Gene therapy, Cancer -- Genetic aspects, Antimitotic agents, Biotechnology industry, Health, Science and technology
Abstract

By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Investigators discuss new findings in Biotechnology. According to news reporting originating from Rome, Italy, by NewsRx editors, the [...]

Published
2013

23. The Leukemia & Lymphoma Society Celebrates September as Blood Cancer Awareness Month

Subjects
Societies, Leukemia -- Genetic aspects -- Care and treatment, Cancer -- Care and treatment, Associations, institutions, etc., Biotechnology industry, Health, Science and technology, The Leukemia & Lymphoma Society
Abstract

By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Remarkable progress has been made in treating patients with blood cancers, with survival rates for many having doubled [...]

Published
2012

24. Scientists map genetic evolution of leukemia

Subjects
Nucleotide sequencing, Genetic research, Leukemia -- Genetic aspects -- Care and treatment, DNA sequencing, Cancer -- Care and treatment -- Genetic aspects, Scientists, Biological sciences, Health, Washington University. School of Medicine
Abstract

The diagnosis of myelodysplastic syndrome, a blood cancer, often causes confusion. While some patients can be treated with repeated blood transfusions, others require chemotherapy, leaving some uncertainty about whether the [...]

Published
2012

25. DNA of 50 breast cancer patients decoded

Subjects
Genomics, DNA, Genetic research, Cancer patients -- Care and treatment, Leukemia -- Genetic aspects -- Care and treatment, Genomes, Cancer -- Care and treatment -- Genetic aspects, Breast cancer -- Genetic aspects -- Care and treatment, DNA binding proteins, Health
Abstract

In the single largest cancer genomics investigation reported to date, scientists have sequenced the whole genomes of tumors from 50 breast cancer patients and compared them to the matched DNA [...]

Published
2011

26. City of Hope Reaches Historic Treatment Milestone with 10,000th Bone Marrow Transplant

Subjects
HIV (Viruses) -- Genetic aspects -- Care and treatment, Leukemia -- Genetic aspects -- Care and treatment, Bone marrow -- Transplantation, Stem cells, Lymphomas -- Genetic aspects -- Care and treatment, Hematopoietic stem cells -- Transplantation, Cancer -- Genetic aspects, Multiple myeloma -- Genetic aspects -- Care and treatment, AIDS (Disease) -- Genetic aspects -- Care and treatment, Pharmaceuticals and cosmetics industries, Health, Science and technology
Abstract

City of Hope, which helped pioneer bone marrow transplantation three and a half decades ago, performed its 10,000th transplant on Jan. 13, becoming one of the first institutions in the [...]

Published
2011

27. Complete Genomics to Sequence 100 Genomes for National Cancer Institute Pediatric Cancer Study

Subjects
Oncology, Experimental, Pediatrics, Genomics, Leukemia -- Genetic aspects -- Care and treatment, Biotechnology industry, Genomes, Cancer -- Care and treatment -- Genetic aspects -- Research, Cancer in children -- Genetic aspects -- Care and treatment, Pharmaceuticals and cosmetics industries
Abstract

Complete Genomics Inc., a life sciences company focused on human genome sequencing, announced a collaboration to identify and validate somatic mutations from 50 pediatric cancer cases from multiple research centers [...]

Published
2010

28. Gene transduction corrects cells from patients with Wiskott-Aldrich syndrome

Subjects
Medical research, Medicine, Experimental, T cells, Leukemia -- Genetic aspects -- Care and treatment, Wiskott-Aldrich syndrome -- Genetic aspects -- Care and treatment, Gene therapy, Hematopoietic stem cells -- Transplantation, Health, Care and treatment, Genetic aspects
Abstract

Gene transduction corrects cells from patients with Wiskott-Aldrich syndrome. According to a study from Italy, "Wiskott-Aldrich syndrome (WAS) is an X-linked primary immunodeficiency with a median survival below the age [...]

Published
2005

29. Antisense molecules targeting Wilms tumor gene exon 5 may treat cancer

Subjects
Oncology, Experimental, Genetic research, Leukemia -- Genetic aspects -- Care and treatment, Cancer -- Care and treatment -- Genetic aspects -- Research, Nephroblastoma -- Genetic aspects -- Care and treatment, Health, Care and treatment, Genetic aspects
Abstract

Antisense molecules targeting Wilms tumor gene exon 5 may treat cancer. According to recent research published in the journal Molecular Cancer Therapeutics, "deregulated expression of the Wilms tumor gene (WT1) [...]

Published
2005

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