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1. Two-year cardio-pulmonary follow-up after severe COVID-19: a prospective study

Author

Faverio, P, Paciocco, G, Tassistro, E, Rebora, P, Rossi, E, Monzani, A, Tundo, M, Milano, C, Messa, M, Marocchi, R, Pesci, A, Foti, G, Squillace, N, Cogliandro, V, Lettino, M, Strepparava, M, Bellelli, G, Ferrarese, C, Valsecchi, M, Bonfanti, P, Luppi, F, Faverio, Paola, Paciocco, Giuseppe, Tassistro, Elena, Rebora, Paola, Rossi, Emanuela, Monzani, Anna, Tundo, Marta, Milano, Chiara, Messa, Martina, Marocchi, Raffaele, Pesci, Alberto, Foti, Giuseppe, Squillace, Nicola, Cogliandro, Viola, Lettino, Maddalena, Strepparava, Maria Grazia, Bellelli, Giuseppe, Ferrarese, Carlo, Valsecchi, Maria Grazia, Bonfanti, Paolo, Luppi, Fabrizio, Faverio, P, Paciocco, G, Tassistro, E, Rebora, P, Rossi, E, Monzani, A, Tundo, M, Milano, C, Messa, M, Marocchi, R, Pesci, A, Foti, G, Squillace, N, Cogliandro, V, Lettino, M, Strepparava, M, Bellelli, G, Ferrarese, C, Valsecchi, M, Bonfanti, P, Luppi, F, Faverio, Paola, Paciocco, Giuseppe, Tassistro, Elena, Rebora, Paola, Rossi, Emanuela, Monzani, Anna, Tundo, Marta, Milano, Chiara, Messa, Martina, Marocchi, Raffaele, Pesci, Alberto, Foti, Giuseppe, Squillace, Nicola, Cogliandro, Viola, Lettino, Maddalena, Strepparava, Maria Grazia, Bellelli, Giuseppe, Ferrarese, Carlo, Valsecchi, Maria Grazia, Bonfanti, Paolo, and Luppi, Fabrizio

Abstract

Short- and medium-term cardio-pulmonary sequelae after COVID-19 have been extensively studied. However, studies with longer follow-ups are required. This study aims to identify and characterise cardio-pulmonary sequelae, in patients hospitalised for SARS-CoV-2 pneumonia, at 24 months follow-up. This is a prospective, observational cohort study conducted on consecutive patients hospitalised for COVID-19 and acute respiratory failure. Patients were followed up at 24 months with complete pulmonary function tests (PFTs), 6-min walking test and a dyspnoea score (Modified Medical Research Council scale). A subgroup of patients with at least one clinical or functional sign suggestive of increased pulmonary pressures also underwent transthoracic echocardiography (TTE) to evaluate the presence of direct or indirect signs of pulmonary hypertension (PH). Ninety consecutive patients (74% men, median age 59.1 years) were enrolled in the study. In regard to PFTs, carbon monoxide diffusion capacity (DLCO) impairment was observed in 23 cases (26%), in all cases of mild entity. When considering the dyspnoea, 30 (34%) patients showed some degree of breathlessness. Forty patients underwent TTE. No patients had overt PH or chronic thromboembolic PH. However, all patients showed a hyperdynamic state of the right ventricle, and 8 (20%) patients had a decreased acceleration time on pulmonary valve, signs of increased pulmonary vasculature resistances and afterload elevation. At 24-month follow-up after severe COVID-19, DLCO and TTE prove to be the most sensitive tool to detect cardio-pulmonary sequelae. Dyspnoea is still present in about one-third of patients and requires a multidisciplinary approach.

Published
2024

2. The frail patient undergoing cardiac surgery: lessons learned and future perspectives

Author

Pozzi, M, Mariani, S, Scanziani, M, Passolunghi, D, Bruni, A, Finazzi, A, Lettino, M, Foti, G, Bellelli, G, Marchetto, G, Pozzi M., Mariani S., Scanziani M., Passolunghi D., Bruni A., Finazzi A., Lettino M., Foti G., Bellelli G., Marchetto G., Pozzi, M, Mariani, S, Scanziani, M, Passolunghi, D, Bruni, A, Finazzi, A, Lettino, M, Foti, G, Bellelli, G, Marchetto, G, Pozzi M., Mariani S., Scanziani M., Passolunghi D., Bruni A., Finazzi A., Lettino M., Foti G., Bellelli G., and Marchetto G.

Abstract

Frailty is a geriatric condition characterized by the reduction of the individual's homeostatic reserves. It determines an increased vulnerability to endogenous and exogenous stressors and can lead to poor outcomes. It is an emerging concept in perioperative medicine, since an increasing number of patients undergoing surgical interventions are older and the traditional models of care seem to be inadequate to satisfy these patients' emerging clinical needs. Nowadays, the progressive technical and clinical improvements allow to offer cardiac operations to an older, sicker and frail population. For these reasons, a multidisciplinary team involving cardiac surgeons, clinical cardiologists, anesthesiologists, and geriatricians, is often needed to assess, select and provide tailored care to these high-risk frail patients to optimize clinical outcomes. There is unanimous agreement that frailty assessment may capture the individual's biological decline and the heterogeneity in risk profile for poor health-related outcomes among people of the same age. However, since commonly used preoperative scores for cardiac surgery fail to capture frailty, a specific preoperative assessment with dedicated tools is warranted to correctly recognize, measure and quantify frailty in these patients. On the contrary, pre-operative and post-operative interventions can reduce the risk of complications and support patient recovery promoting surgical resilience. Minimally invasive cardiac procedures aim to reduce surgical trauma and may be associated with better clinical outcome in this specific sub-group of high-risk patients. Among postoperative adverse events, the occurrence of delirium represents a risk factor for several unfavorable outcomes including mortality and subsequent cognitive decline. Its presence should be carefully recognized, triggering an adequate, evidence based, treatment. There is evidence, from several cross-section and longitudinal studies, that frailty and delirium may fr

Published
2023

3. Come superare le barriere all'implementazione delle strategie di prevenzione e cura della malattia cardiovascolare aterosclerotica mediante terapia ipolipemizzante

Author

Arca, M, Averna, M, Borghi, C, Lettino, M, Filardi, P, Alberti, A, Bilato, C, Calabrò, P, Carubbi, F, Ciccone, M, Cipollone, F, Citroni, N, De Luca, L, Giaccari, A, Iannuzzo, G, Maloberti, A, Marcucci, R, Spinazzola, P, Pirro, M, Pisciotta, L, Sarullo, F, Sciacqua, A, Suppressa, P, Varbella, F, Werba, J, Zambon, A, Arca M., Averna M., Borghi C., Lettino M., Filardi P. P., Alberti A., Bilato C., Calabrò P., Carubbi F., Ciccone M. M., Cipollone F., Citroni N., De Luca L., Giaccari A., Iannuzzo G., Maloberti A., Marcucci R., Spinazzola P. P., Pirro M., Pisciotta L., Sarullo F., Sciacqua A., Suppressa P., Varbella F., Werba J. P., Zambon A., Arca, M, Averna, M, Borghi, C, Lettino, M, Filardi, P, Alberti, A, Bilato, C, Calabrò, P, Carubbi, F, Ciccone, M, Cipollone, F, Citroni, N, De Luca, L, Giaccari, A, Iannuzzo, G, Maloberti, A, Marcucci, R, Spinazzola, P, Pirro, M, Pisciotta, L, Sarullo, F, Sciacqua, A, Suppressa, P, Varbella, F, Werba, J, Zambon, A, Arca M., Averna M., Borghi C., Lettino M., Filardi P. P., Alberti A., Bilato C., Calabrò P., Carubbi F., Ciccone M. M., Cipollone F., Citroni N., De Luca L., Giaccari A., Iannuzzo G., Maloberti A., Marcucci R., Spinazzola P. P., Pirro M., Pisciotta L., Sarullo F., Sciacqua A., Suppressa P., Varbella F., Werba J. P., and Zambon A.

Abstract

Atherosclerotic cardiovascular diseases remain the main cause of mortality worldwide, due to a poor control of modifiable risk factors for atherosclerosis. High levels of low-density lipoprotein cholesterol represent the most relevant actor in the development of atherosclerotic cardiovascular diseases, as well as the main target promuovoof prevention strategies. Although lipid-lowering treatments were shown to be effective for cardiovascular prevention, several barriers (e.g. clinician reluctance to prescribe an intensive treatment, poor adherence of patients to therapy, high pharmacotherapy burden of high-risk patients and the fear for adverse events potentially associated with statins) still prevent therapy optimization. Such issues will be addressed in this review article, taking into account possible strategies for their solution, through an integrated approach including both management interventions and a larger use of the available pharmacologic options.

Published
2023

5. Presentation, care and outcomes of patients with NSTEMI according to World Bank country income classification: Prospective international multicentre cohort study of the ESC EORP NSTEMI registry

Author

Nadarajah, R, primary, Ludman, P, additional, Appelman, Y, additional, Brugaletta, S, additional, Budaj, A, additional, Bueno, H, additional, Huber, K, additional, Kunadian, V, additional, Leonardi, S, additional, Lettino, M, additional, Milasinovic, D, additional, and Gale, C P, additional

Published
2023
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6. A multidisciplinary approach to screen the post-COVID-19 conditions

Author

Squillace, N, Cogliandro, V, Rossi, E, Bellelli, G, Pozzi, M, Luppi, F, Lettino, M, Strepparava, M, Ferrarese, C, Pollastri, E, Ricci, E, Bonfanti, P, Squillace, Nicola, Cogliandro, Viola, Rossi, Emanuela, Bellelli, Giuseppe, Pozzi, Matteo, Luppi, Fabrizio, Lettino, Maddalena, Strepparava, Maria Grazia, Ferrarese, Carlo, Pollastri, Ester, Ricci, Elena, Bonfanti, Paolo, Squillace, N, Cogliandro, V, Rossi, E, Bellelli, G, Pozzi, M, Luppi, F, Lettino, M, Strepparava, M, Ferrarese, C, Pollastri, E, Ricci, E, Bonfanti, P, Squillace, Nicola, Cogliandro, Viola, Rossi, Emanuela, Bellelli, Giuseppe, Pozzi, Matteo, Luppi, Fabrizio, Lettino, Maddalena, Strepparava, Maria Grazia, Ferrarese, Carlo, Pollastri, Ester, Ricci, Elena, and Bonfanti, Paolo

Abstract

BACKGROUND: Post-COronaVIrus Disease 2019 (COVID-19) conditions (PCC) include multiple symptoms afflicting different organs and systems. To evaluate the frequency and type of them, we described our multidisciplinary approach with preliminary results of the first enrolled patients. METHODS: We included patients aged ≥ 18 years with hospital admission for confirmed SARS-CoV-2 infection. Symptoms were grouped in five macro groups hereafter referred to as "Symptoms Category" (SC): respiratory SC (dyspnoea or cough), neurological SC (peripheral neuropathies, headache, impaired mobility, behavioural disorders), psychological SC (sleep disorders, mood disorders), muscular SC (arthromyalgia, asthenia), other SC (fever, alopecia, diarrhoea, weight loss, smell and taste alterations, sexual dysfunctions). SC were evaluated at discharge and at follow-up. Association between patients' characteristics and presence of SC at follow up was estimated by a logistic multivariable regression model. RESULTS: From June 2020 to July 2021, we followed up 361 patients: 128 (35.5%) who were previously admitted to Intensive Care Unit (ICU) and 233 patients to ordinary department. The median length of hospital stay was 20 days (Inter-Quartile-Range 13-32). Most patients (317/361, 87.8%) were still symptomatic at discharge, with one third referring three or more SC. At follow up, 67.3% (243/361) of patients still complained at least one SC. Moreover, 159 patients (44%) developed at least one new involved SC during follow up: 116 (72.9%) one SC, 39 (24.5%) two SC, 4 (2.5%) three or more SC. At follow up visit 130 of 361 (36%) were still with SC developed during follow up. At multivariable analysis presence of any SC at follow-up was associated with male gender (Odds Ratio [OR] 3.23, Confidence Interval [CI] 95% 1.46-7.15), ICU admission (OR 2.78, CI 95% 1.29-5.96) and presence of SC at discharge (OR 14.39, CI 95% 6.41-32.32). CONCLUSIONS: In our sample of patients with severe COVID-19, we found t

Published
2023

7. Frailty and long-COVID: is COVID-19 responsible for a transition in frailty status among older adults who survived hospitalization for COVID-19?

Author

Ferrara, M, Zarcone, C, Tassistro, E, Rebora, P, Rossi, E, Luppi, F, Foti, G, Squillace, N, Lettino, M, Strepparava, M, Bonfanti, P, Bellelli, G, Ferrara, Maria Cristina, Zarcone, Cristina, Tassistro, Elena, Rebora, Paola, Rossi, Emanuela, Luppi, Fabrizio, Foti, Giuseppe, Squillace, Nicola, Lettino, Maddalena, Strepparava, Maria Grazia, Bonfanti, Paolo, Bellelli, Giuseppe, Ferrara, M, Zarcone, C, Tassistro, E, Rebora, P, Rossi, E, Luppi, F, Foti, G, Squillace, N, Lettino, M, Strepparava, M, Bonfanti, P, Bellelli, G, Ferrara, Maria Cristina, Zarcone, Cristina, Tassistro, Elena, Rebora, Paola, Rossi, Emanuela, Luppi, Fabrizio, Foti, Giuseppe, Squillace, Nicola, Lettino, Maddalena, Strepparava, Maria Grazia, Bonfanti, Paolo, and Bellelli, Giuseppe

Abstract

Background: There is a paucity of knowledge about the effects of COronaVIrus Disease-19 (COVID-19) on long-term frailty development or progression over time. Aim: This study aims to assess transitions in frailty status in older adults who survived hospitalization for COVID-19. Methods: This is a longitudinal panel study. A multidisciplinary outpatient follow-up service was established since summer 2020, for the evaluation of individuals discharged alive, after hospitalization due to COVID-19. Frailty status was assessed in-hospital and at follow-up using the clinical frailty scale (CFS). Main patients’ characteristics, including health, functional, cognitive, and psychological status were collected. Results: A total of 177 patients aged 65 years and older were evaluated until June 2022. They were predominantly male, with a median age of 70 (Q1–Q3 67–75) years and a median body mass index of 27.5 (Q1–Q3 24.9–30.6) kg/m2 at hospital admission. The median follow-up time was 6.3 (Q1–Q3 3.7–10.9) months. Sixty-one patients (34.5%) scored worse at CFS follow-up compared to hospital admission, and twenty-two patients (12.4%) became frail. Discussion and conclusion: This study shows that one out of three older patients previously hospitalized for COVID-19 had an unfavorable transition in CFS score during a median follow-up of nearly 6 months. Specific interventions to prevent frailty development or progression should be considered for patients at risk. Further studies are required to confirm our findings.

Published
2023

8. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice

Author

Visseren, F, Mach, F, Smulders, Y, Carballo, D, Koskinas, K, Back, M, Benetos, A, Biffi, A, Boavida, J, Capodanno, D, Cosyns, B, Crawford, C, Davos, C, Desormais, I, Di Angelantonio, E, Duran, O, Halvorsen, S, Richard Hobbs, F, Hollander, M, Jankowska, E, Michal, M, Sacco, S, Sattar, N, Tokgozoglu, L, Tonstad, S, Tsioufis, K, van Dis, I, van Gelder, I, Wanner, C, Williams, B, De Backer, G, Regitz-Zagrosek, V, Aamodt, A, Abdelhamid, M, Aboyans, V, Albus, C, Asteggiano, R, Borger, M, Brotons, C, Celutkiene, J, Cifkova, R, Cikes, M, Cosentino, F, Dagres, N, De Backer, T, De Bacquer, D, Delgado, V, Ruijter, H, Dendale, P, Drexel, H, Falk, V, Fauchier, L, Ference, B, Ferrieres, J, Ferrini, M, Fisher, M, Fliser, D, Fras, Z, Gaita, D, Giampaoli, S, Gielen, S, Graham, I, Jennings, C, Jorgensen, T, Kautzky-Willer, A, Kavousi, M, Koenig, W, Konradi, A, Kotecha, D, Landmesser, U, Lettino, M, Lewis, B, Linhart, A, Lochen, M, Makrilakis, K, Mancia, G, Marques-Vidal, P, Mcevoy, J, Mcgreavy, P, Merkely, B, Neubeck, L, Nielsen, J, Perk, J, Petersen, S, Petronio, A, Piepoli, M, Pogosova, N, Prescott, E, Ray, K, Reiner, Z, Richter, D, Ryden, L, Shlyakhto, E, Sitges, M, Sousa-Uva, M, Sudano, I, Tiberi, M, Touyz, R, Ungar, A, Monique Verschuren, W, Wiklund, O, Wood, D, Zamorano, J, Visseren F., Mach F., Smulders Y. M., Carballo D., Koskinas K. C., Back M., Benetos A., Biffi A., Boavida J. -M., Capodanno D., Cosyns B., Crawford C. A., Davos C. H., Desormais I., Di Angelantonio E., Duran O. H. F., Halvorsen S., Richard Hobbs F. D., Hollander M., Jankowska E. A., Michal M., Sacco S., Sattar N., Tokgozoglu L., Tonstad S., Tsioufis K. P., van Dis I., van Gelder I. C., Wanner C., Williams B., De Backer G., Regitz-Zagrosek V., Aamodt A. H., Abdelhamid M., Aboyans V., Albus C., Asteggiano R., Borger M. A., Brotons C., Celutkiene J., Cifkova R., Cikes M., Cosentino F., Dagres N., De Backer T., De Bacquer D., Delgado V., Ruijter H. D., Dendale P., Drexel H., Falk V., Fauchier L., Ference B. A., Ferrieres J., Ferrini M., Fisher M., Fliser D., Fras Z., Gaita D., Giampaoli S., Gielen S., Graham I., Jennings C., Jorgensen T., Kautzky-Willer A., Kavousi M., Koenig W., Konradi A., Kotecha D., Landmesser U., Lettino M., Lewis B. S., Linhart A., Lochen M. -L., Makrilakis K., Mancia G., Marques-Vidal P., McEvoy J. W., McGreavy P., Merkely B., Neubeck L., Nielsen J. C., Perk J., Petersen S. E., Petronio A. S., Piepoli M., Pogosova N. G., Prescott E. I. B., Ray K. K., Reiner Z., Richter D. J., Ryden L., Shlyakhto E., Sitges M., Sousa-Uva M., Sudano I., Tiberi M., Touyz R. M., Ungar A., Monique Verschuren W. M., Wiklund O., Wood D., Zamorano J. L., Visseren, F, Mach, F, Smulders, Y, Carballo, D, Koskinas, K, Back, M, Benetos, A, Biffi, A, Boavida, J, Capodanno, D, Cosyns, B, Crawford, C, Davos, C, Desormais, I, Di Angelantonio, E, Duran, O, Halvorsen, S, Richard Hobbs, F, Hollander, M, Jankowska, E, Michal, M, Sacco, S, Sattar, N, Tokgozoglu, L, Tonstad, S, Tsioufis, K, van Dis, I, van Gelder, I, Wanner, C, Williams, B, De Backer, G, Regitz-Zagrosek, V, Aamodt, A, Abdelhamid, M, Aboyans, V, Albus, C, Asteggiano, R, Borger, M, Brotons, C, Celutkiene, J, Cifkova, R, Cikes, M, Cosentino, F, Dagres, N, De Backer, T, De Bacquer, D, Delgado, V, Ruijter, H, Dendale, P, Drexel, H, Falk, V, Fauchier, L, Ference, B, Ferrieres, J, Ferrini, M, Fisher, M, Fliser, D, Fras, Z, Gaita, D, Giampaoli, S, Gielen, S, Graham, I, Jennings, C, Jorgensen, T, Kautzky-Willer, A, Kavousi, M, Koenig, W, Konradi, A, Kotecha, D, Landmesser, U, Lettino, M, Lewis, B, Linhart, A, Lochen, M, Makrilakis, K, Mancia, G, Marques-Vidal, P, Mcevoy, J, Mcgreavy, P, Merkely, B, Neubeck, L, Nielsen, J, Perk, J, Petersen, S, Petronio, A, Piepoli, M, Pogosova, N, Prescott, E, Ray, K, Reiner, Z, Richter, D, Ryden, L, Shlyakhto, E, Sitges, M, Sousa-Uva, M, Sudano, I, Tiberi, M, Touyz, R, Ungar, A, Monique Verschuren, W, Wiklund, O, Wood, D, Zamorano, J, Visseren F., Mach F., Smulders Y. M., Carballo D., Koskinas K. C., Back M., Benetos A., Biffi A., Boavida J. -M., Capodanno D., Cosyns B., Crawford C. A., Davos C. H., Desormais I., Di Angelantonio E., Duran O. H. F., Halvorsen S., Richard Hobbs F. D., Hollander M., Jankowska E. A., Michal M., Sacco S., Sattar N., Tokgozoglu L., Tonstad S., Tsioufis K. P., van Dis I., van Gelder I. C., Wanner C., Williams B., De Backer G., Regitz-Zagrosek V., Aamodt A. H., Abdelhamid M., Aboyans V., Albus C., Asteggiano R., Borger M. A., Brotons C., Celutkiene J., Cifkova R., Cikes M., Cosentino F., Dagres N., De Backer T., De Bacquer D., Delgado V., Ruijter H. D., Dendale P., Drexel H., Falk V., Fauchier L., Ference B. A., Ferrieres J., Ferrini M., Fisher M., Fliser D., Fras Z., Gaita D., Giampaoli S., Gielen S., Graham I., Jennings C., Jorgensen T., Kautzky-Willer A., Kavousi M., Koenig W., Konradi A., Kotecha D., Landmesser U., Lettino M., Lewis B. S., Linhart A., Lochen M. -L., Makrilakis K., Mancia G., Marques-Vidal P., McEvoy J. W., McGreavy P., Merkely B., Neubeck L., Nielsen J. C., Perk J., Petersen S. E., Petronio A. S., Piepoli M., Pogosova N. G., Prescott E. I. B., Ray K. K., Reiner Z., Richter D. J., Ryden L., Shlyakhto E., Sitges M., Sousa-Uva M., Sudano I., Tiberi M., Touyz R. M., Ungar A., Monique Verschuren W. M., Wiklund O., Wood D., and Zamorano J. L.

Published
2021

9. European Society of Cardiology guidance for the diagnosis and management of cardiovascular disease during the COVID-19 pandemic: part 1—epidemiology, pathophysiology, and diagnosis

Author

Baigent, C., Windecker, S., Andreini, D., Arbelo, E., Barbato, E., Bartorelli, A.L., Baumbach, A., Behr, E.R., Berti, S., Bueno, H., Capodanno, D., Cappato, R., Chieffo, A., Collet, J.P., Cuisset, T., Simone, G. de, Delgado, V., Dendale, P., Dudek, D., Edvardsen, T., Elvan, A., Gonzalez-Juanatey, J.R., Gori, M., Grobbee, D., Guzik, T.J., Halvorsen, S., Haude, M., Heidbuchel, H., Hindricks, G., Ibanez, B., Karam, N., Katus, H., Klok, F.A., Konstantinides, S.V., Landmesser, U., Leclercq, C., Leonardi, S., Lettino, M., Marenzi, G., Mauri, J., Metra, M., Morici, N., Mueller, C., Petronio, A.S., Polovina, M.M., Potpara, T., Praz, F., Prendergast, B., Prescott, E., Price, S., Pruszczyk, P., Rodriguez-Leor, O., Roffi, M., Romaguera, R., Rosenkranz, S., Sarkozy, A., Scherrenberg, M., Seferovic, P., Senni, M., Spera, F.R., Stefanini, G., Thiele, H., Tomasoni, D., Torracca, L., Touyz, R.M., Wilde, A.A., Williams, B., Task Force Management Covid-19 Eur, Nuffield Department of Population Health [Oxford], University of Oxford, Bern University Hospital [Berne] (Inselspital), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Nutrition, obésité et risque thrombotique (NORT), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), CHU Pontchaillou [Rennes], Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Glasgow, Amsterdam UMC - Amsterdam University Medical Center, University College of London [London] (UCL), Baigent, C, Cardiology, Task Force for the management of COVID-19 of the European Society of, Cardiology, ACS - Heart failure & arrhythmias, Task Force Management Covid-19 Eur, University of Oxford [Oxford], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), delgado, victoria/0000-0002-9841-2737, BUENO, HECTOR/0000-0003-0277-7596, Karam, Nicole/0000-0002-3861-6914, Baigent, Colin/0000-0003-4856-7420, Behr, Elijah/0000-0002-8731-2853, Williams, Bryan/0000-0002-8094-1841, Rodriguez-Leor, Oriol/0000-0003-2657-5657, BUENO, HECTOR/0000-0003-0277-7596, Rodriguez-Leor, Oriol/0000-0003-2657-5657, Williams, Bryan/0000-0002-8094-1841, Karam, and Nicole/0000-0002-3861-6914

Subjects
ACE2, Arrhythmias, Biomarkers, Cardiogenic shock, COVID-19, Myocardial, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Physiology, Myocardial injury, Myocarditis, Non-invasive imaging, Humans, Pandemics, Prospective Studies, Cardiology, Cardiovascular Diseases, Settore MED/11 - Malattie dell'Apparato Cardiovascolare, Disease, Special Article, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Physiology (medical), injury, Pandemic, Epidemiology, Medicine, AcademicSubjects/MED00200, Intensive care medicine, business.industry, Pathophysiology, Human medicine, Cardiology and Cardiovascular Medicine, business
Abstract

Aims Since its emergence in early 2020, the novel severe acute respiratory syndrome coronavirus 2 causing coronavirus disease 2019 (COVID-19) has reached pandemic levels, and there have been repeated outbreaks across the globe. The aim of this two-part series is to provide practical knowledge and guidance to aid clinicians in the diagnosis and management of cardiovascular disease (CVD) in association with COVID-19. Methods and results A narrative literature review of the available evidence has been performed, and the resulting information has been organized into two parts. The first, reported here, focuses on the epidemiology, pathophysiology, and diagnosis of cardiovascular (CV) conditions that may be manifest in patients with COVID-19. The second part, which will follow in a later edition of the journal, addresses the topics of care pathways, treatment, and follow-up of CV conditions in patients with COVID-19. Conclusion This comprehensive review is not a formal guideline but rather a document that provides a summary of current knowledge and guidance to practicing clinicians managing patients with CVD and COVID-19. The recommendations are mainly the result of observations and personal experience from healthcare providers. Therefore, the information provided here may be subject to change with increasing knowledge, evidence from prospective studies, and changes in the pandemic. Likewise, the guidance provided in the document should not interfere with recommendations provided by local and national healthcare authorities., Graphical Abstract Graphical Abstract

Published
2022

10. 2019 ESC Guidelines for themanagement of patients with supraventricular tachycardia

Author

Brugada, J, Katritsis, D, Arbelo, E, Arribas, F, Bax, J, Blomstrom-Lundqvist, C, Calkins, H, Corrado, D, Deftereos, S, Diller, G, Gomez-Doblas, J, Gorenek, B, Grace, A, Ho, S, Kaski, J, Kuck, K, Lambiase, P, Sacher, F, Sarquella-Brugada, G, Suwalski, P, Zaza, A, De Potter, T, Sticherling, C, Aboyans, V, Basso, C, Bocchiardo, M, Budts, W, Delgado, V, Dobrev, D, Fitzsimons, D, Gevaert, S, Heidbuchel, H, Hindricks, G, Hlivak, P, Kanagaratnam, P, Katus, H, Kautzner, J, Kriebel, T, Lancellotti, P, Landmesser, U, Leclercq, C, Lewis, B, Lopatin, Y, Merkely, B, Paul, T, Pavlovic, N, Petersen, S, Petronio, A, Potpara, T, Roffi, M, Scherr, D, Shlyakhto, E, Simpson, I, Zeppenfeld, K, Windecker, S, Baigent, C, Collet, J, Dean, V, Gale, C, Grobbee, D, Halvorsen, S, Iung, B, Juni, P, Lettino, M, Mueller, C, Richter, D, Sousa-Uva, M, Touyz, R, Amara, W, Grigoryan, S, Podczeck-Schweighofer, A, Chasnoits, A, Vandekerckhove, Y, Sokolovich, S, Traykov, V, Skoric, B, Papasavvas, E, Riahi, S, Kampus, P, Parikka, H, Piot, O, Etsadashvili, K, Stellbrink, C, Manolis, A, Csanadi, Z, Gudmundsson, K, Erwin, J, Barsheshet, A, De Ponti, R, Abdrakhmanov, A, Jashari, H, Lunegova, O, Jubele, K, Refaat, M, Puodziukynas, A, Groben, L, Grosu, A, Ibtissam, F, Trines, S, Poposka, L, Haugaa, K, Kowalski, O, Cavaco, D, Dobreanu, D, Mikhaylov, E, Zavatta, M, Nebojsa, M, Ferreira-Gonzalez, I, Juhlin, T, Reichlin, T, Haouala, H, Akgun, T, Gupta, D, Brugada J., Katritsis D. G., Arbelo E., Arribas F., Bax J. J., Blomstrom-Lundqvist C., Calkins H., Corrado D., Deftereos S. G., Diller G. -P., Gomez-Doblas J. J., Gorenek B., Grace A., Ho S. Y., Kaski J. -C., Kuck K. -H., Lambiase P. D., Sacher F., Sarquella-Brugada G., Suwalski P., Zaza A., De Potter T., Sticherling C., Aboyans V., Basso C., Bocchiardo M., Budts W., Delgado V., Dobrev D., Fitzsimons D., Gevaert S., Heidbuchel H., Hindricks G., Hlivak P., Kanagaratnam P., Katus H., Kautzner J., Kriebel T., Lancellotti P., Landmesser U., Leclercq C., Lewis B., Lopatin Y., Merkely B., Paul T., Pavlovic N., Petersen S., Petronio A. S., Potpara T., Roffi M., Scherr D., Shlyakhto E., Simpson I. A., Zeppenfeld K., Windecker S., Baigent C., Collet J. -P., Dean V., Gale C. P., Grobbee D. E., Halvorsen S., Iung B., Juni P., Lettino M., Mueller C., Richter D. J., Sousa-Uva M., Touyz R. M., Amara W., Grigoryan S., Podczeck-Schweighofer A., Chasnoits A., Vandekerckhove Y., Sokolovich S., Traykov V., Skoric B., Papasavvas E., Riahi S., Kampus P., Parikka H., Piot O., Etsadashvili K., Stellbrink C., Manolis A. S., Csanadi Z., Gudmundsson K., Erwin J., Barsheshet A., De Ponti R., Abdrakhmanov A., Jashari H., Lunegova O., Jubele K., Refaat M. M., Puodziukynas A., Groben L., Grosu A., Ibtissam F., Trines S. A., Poposka L., Haugaa K. H., Kowalski O., Cavaco D., Dobreanu D., Mikhaylov E. N., Zavatta M., Nebojsa M., Ferreira-Gonzalez I., Juhlin T., Reichlin T., Haouala H., Akgun T., Gupta D., Brugada, J, Katritsis, D, Arbelo, E, Arribas, F, Bax, J, Blomstrom-Lundqvist, C, Calkins, H, Corrado, D, Deftereos, S, Diller, G, Gomez-Doblas, J, Gorenek, B, Grace, A, Ho, S, Kaski, J, Kuck, K, Lambiase, P, Sacher, F, Sarquella-Brugada, G, Suwalski, P, Zaza, A, De Potter, T, Sticherling, C, Aboyans, V, Basso, C, Bocchiardo, M, Budts, W, Delgado, V, Dobrev, D, Fitzsimons, D, Gevaert, S, Heidbuchel, H, Hindricks, G, Hlivak, P, Kanagaratnam, P, Katus, H, Kautzner, J, Kriebel, T, Lancellotti, P, Landmesser, U, Leclercq, C, Lewis, B, Lopatin, Y, Merkely, B, Paul, T, Pavlovic, N, Petersen, S, Petronio, A, Potpara, T, Roffi, M, Scherr, D, Shlyakhto, E, Simpson, I, Zeppenfeld, K, Windecker, S, Baigent, C, Collet, J, Dean, V, Gale, C, Grobbee, D, Halvorsen, S, Iung, B, Juni, P, Lettino, M, Mueller, C, Richter, D, Sousa-Uva, M, Touyz, R, Amara, W, Grigoryan, S, Podczeck-Schweighofer, A, Chasnoits, A, Vandekerckhove, Y, Sokolovich, S, Traykov, V, Skoric, B, Papasavvas, E, Riahi, S, Kampus, P, Parikka, H, Piot, O, Etsadashvili, K, Stellbrink, C, Manolis, A, Csanadi, Z, Gudmundsson, K, Erwin, J, Barsheshet, A, De Ponti, R, Abdrakhmanov, A, Jashari, H, Lunegova, O, Jubele, K, Refaat, M, Puodziukynas, A, Groben, L, Grosu, A, Ibtissam, F, Trines, S, Poposka, L, Haugaa, K, Kowalski, O, Cavaco, D, Dobreanu, D, Mikhaylov, E, Zavatta, M, Nebojsa, M, Ferreira-Gonzalez, I, Juhlin, T, Reichlin, T, Haouala, H, Akgun, T, Gupta, D, Brugada J., Katritsis D. G., Arbelo E., Arribas F., Bax J. J., Blomstrom-Lundqvist C., Calkins H., Corrado D., Deftereos S. G., Diller G. -P., Gomez-Doblas J. J., Gorenek B., Grace A., Ho S. Y., Kaski J. -C., Kuck K. -H., Lambiase P. D., Sacher F., Sarquella-Brugada G., Suwalski P., Zaza A., De Potter T., Sticherling C., Aboyans V., Basso C., Bocchiardo M., Budts W., Delgado V., Dobrev D., Fitzsimons D., Gevaert S., Heidbuchel H., Hindricks G., Hlivak P., Kanagaratnam P., Katus H., Kautzner J., Kriebel T., Lancellotti P., Landmesser U., Leclercq C., Lewis B., Lopatin Y., Merkely B., Paul T., Pavlovic N., Petersen S., Petronio A. S., Potpara T., Roffi M., Scherr D., Shlyakhto E., Simpson I. A., Zeppenfeld K., Windecker S., Baigent C., Collet J. -P., Dean V., Gale C. P., Grobbee D. E., Halvorsen S., Iung B., Juni P., Lettino M., Mueller C., Richter D. J., Sousa-Uva M., Touyz R. M., Amara W., Grigoryan S., Podczeck-Schweighofer A., Chasnoits A., Vandekerckhove Y., Sokolovich S., Traykov V., Skoric B., Papasavvas E., Riahi S., Kampus P., Parikka H., Piot O., Etsadashvili K., Stellbrink C., Manolis A. S., Csanadi Z., Gudmundsson K., Erwin J., Barsheshet A., De Ponti R., Abdrakhmanov A., Jashari H., Lunegova O., Jubele K., Refaat M. M., Puodziukynas A., Groben L., Grosu A., Ibtissam F., Trines S. A., Poposka L., Haugaa K. H., Kowalski O., Cavaco D., Dobreanu D., Mikhaylov E. N., Zavatta M., Nebojsa M., Ferreira-Gonzalez I., Juhlin T., Reichlin T., Haouala H., Akgun T., and Gupta D.

Abstract

E' una "linea-guida" non esiste abstract.

Published
2020

11. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice

Author

Visseren, F, Mach, F, Smulders, Y, Carballo, D, Koskinas, K, Bäck, M, Benetos, A, Biffi, A, Boavida, J, Capodanno, D, Cosyns, B, Crawford, C, Davos, C, Desormais, I, Di Angelantonio, E, Franco, O, Halvorsen, S, Hobbs, F, Hollander, M, Jankowska, E, Michal, M, Sacco, S, Sattar, N, Tokgozoglu, L, Tonstad, S, Tsioufis, K, van Dis, I, van Gelder, I, Wanner, C, Williams, B, De Backer, G, Regitz-Zagrosek, V, Aamodt, A, Abdelhamid, M, Aboyans, V, Albus, C, Asteggiano, R, Borger, M, Brotons, C, Celutkiene, J, Cifkova, R, Cikes, M, Cosentino, F, Dagres, N, De Backer, T, De Bacquer, D, Delgado, V, Den Ruijter, H, Dendale, P, Drexel, H, Falk, V, Fauchier, L, Ference, B, Ferrières, J, Ferrini, M, Fisher, M, Fliser, D, Fras, Z, Gaita, D, Giampaoli, S, Gielen, S, Graham, I, Jennings, C, Jorgensen, T, Kautzky-Willer, A, Kavousi, M, Koenig, W, Konradi, A, Kotecha, D, Landmesser, U, Lettino, M, Lewis, B, Linhart, A, Lochen, M, Makrilakis, K, Mancia, G, Marques-Vidal, P, Mcevoy, J, Mcgreavy, P, Merkely, B, Neubeck, L, Nielsen, J, Perk, J, Petersen, S, Petronio, A, Piepoli, M, Pogosova, N, Prescott, E, Ray, K, Reiner, Z, Richter, D, Rydén, L, Shlyakhto, E, Sitges, M, Sousa-Uva, M, Sudano, I, Tiberi, M, Touyz, R, Ungar, A, Verschuren, W, Wiklund, O, Wood, D, Zamorano, J, Visseren, FLJ, Smulders, YM, Koskinas, KC, Boavida, JM, Davos, CH, Franco, OH, Hobbs, FDR, Jankowska, EA, Tsioufis, KP, van Gelder, IC, Aamodt, AH, Borger, MA, Ference, BA, Lewis, BS, Lochen, ML, McEvoy, JW, McGreavy, P, Nielsen, JC, Petersen, SE, Petronio, AS, Pogosova, NG, Prescott, EIB, Ray, KK, Richter, DJ, Touyz, RM, Verschuren, WMM, Zamorano, JL, Visseren, F, Mach, F, Smulders, Y, Carballo, D, Koskinas, K, Bäck, M, Benetos, A, Biffi, A, Boavida, J, Capodanno, D, Cosyns, B, Crawford, C, Davos, C, Desormais, I, Di Angelantonio, E, Franco, O, Halvorsen, S, Hobbs, F, Hollander, M, Jankowska, E, Michal, M, Sacco, S, Sattar, N, Tokgozoglu, L, Tonstad, S, Tsioufis, K, van Dis, I, van Gelder, I, Wanner, C, Williams, B, De Backer, G, Regitz-Zagrosek, V, Aamodt, A, Abdelhamid, M, Aboyans, V, Albus, C, Asteggiano, R, Borger, M, Brotons, C, Celutkiene, J, Cifkova, R, Cikes, M, Cosentino, F, Dagres, N, De Backer, T, De Bacquer, D, Delgado, V, Den Ruijter, H, Dendale, P, Drexel, H, Falk, V, Fauchier, L, Ference, B, Ferrières, J, Ferrini, M, Fisher, M, Fliser, D, Fras, Z, Gaita, D, Giampaoli, S, Gielen, S, Graham, I, Jennings, C, Jorgensen, T, Kautzky-Willer, A, Kavousi, M, Koenig, W, Konradi, A, Kotecha, D, Landmesser, U, Lettino, M, Lewis, B, Linhart, A, Lochen, M, Makrilakis, K, Mancia, G, Marques-Vidal, P, Mcevoy, J, Mcgreavy, P, Merkely, B, Neubeck, L, Nielsen, J, Perk, J, Petersen, S, Petronio, A, Piepoli, M, Pogosova, N, Prescott, E, Ray, K, Reiner, Z, Richter, D, Rydén, L, Shlyakhto, E, Sitges, M, Sousa-Uva, M, Sudano, I, Tiberi, M, Touyz, R, Ungar, A, Verschuren, W, Wiklund, O, Wood, D, Zamorano, J, Visseren, FLJ, Smulders, YM, Koskinas, KC, Boavida, JM, Davos, CH, Franco, OH, Hobbs, FDR, Jankowska, EA, Tsioufis, KP, van Gelder, IC, Aamodt, AH, Borger, MA, Ference, BA, Lewis, BS, Lochen, ML, McEvoy, JW, McGreavy, P, Nielsen, JC, Petersen, SE, Petronio, AS, Pogosova, NG, Prescott, EIB, Ray, KK, Richter, DJ, Touyz, RM, Verschuren, WMM, and Zamorano, JL

Published
2022

12. Project R. Evolution for improving clinical research in Italy: challenges and strategies

Author

Arizio, F, Bonardi, A, Cortinovis, D, Costanzo, A, Cristinziano, A, Delle Monache, L, Landolfi, R, Lettino, M, Luppi, F, Petrangolini, T, Tassielli, D, Arizio, Francesca, Bonardi, Alessio, Cortinovis, Diego, Costanzo, Antonio, Cristinziano, Adriano, Delle Monache, Lina, Landolfi, Raffaele, Lettino, Maddalena, Luppi, Fabrizio, Petrangolini, Teresa, Tassielli, Domenica, Arizio, F, Bonardi, A, Cortinovis, D, Costanzo, A, Cristinziano, A, Delle Monache, L, Landolfi, R, Lettino, M, Luppi, F, Petrangolini, T, Tassielli, D, Arizio, Francesca, Bonardi, Alessio, Cortinovis, Diego, Costanzo, Antonio, Cristinziano, Adriano, Delle Monache, Lina, Landolfi, Raffaele, Lettino, Maddalena, Luppi, Fabrizio, Petrangolini, Teresa, and Tassielli, Domenica

Abstract

Objective: The R.Evolution project aimed to reach a consensus on the main challenges of conducting clinical research in Italy and possible strategies and approaches to address them and optimize clinical research management. Methods: A scientific board of experts initially discussed potentially critical areas in clinical research conduct and further explored them through an online national survey. The survey results were further examined by a group of 35 panelists representing different clinical research stakeholders. A Nominal Group Technique and a Delphi approach (two rounds) were used to generate a consensus on critical factors, tools and strategies in clinical research. Results: Four main critical areas were identified: study feasibility, authorization procedures, operational aspects and patient management. The main issues are scarce awareness of the value of clinical research, lack of trained workforce and excessive complexity of protocols and administrative procedures. The Delphi panel identified six intervention areas: culture and patient involvement; procedures; staff, contracts, training and incentives; organization and infrastructure; administrative procedures; and ethics committee. Conclusion: According to the R.Evolution project, possible strategies to improve clinical research management in Italy include a deeper understanding of the value of clinical research, the creation of long-term plans for hiring, training, organizing and motivating clinical trial staff, the simplification and harmonization of administrative procedures, as well as protocol design, and the development of stronger networks of centers and stakeholders.

Published
2022

13. Cardiac and obstetric outcomes in pregnant women with heart disease: appraisal of the 2018 mWHO classification

Author

Ornaghi, S, Bellante, N, Abbamondi, A, Maini, M, Cesana, F, Trabucchi, M, Corsi, D, Arosio, V, Mariani, S, Scian, A, Colciago, E, Lettino, M, Vergani, P, Ornaghi, Sara, Bellante, Nicolo', Abbamondi, Alessandra, Maini, Marzia, Cesana, Francesca, Trabucchi, Margherita, Corsi, Davide, Arosio, Viola, Mariani, Silvana, Scian, Antonietta, Colciago, Elisabetta, Lettino, Maddalena, Vergani, Patrizia, Ornaghi, S, Bellante, N, Abbamondi, A, Maini, M, Cesana, F, Trabucchi, M, Corsi, D, Arosio, V, Mariani, S, Scian, A, Colciago, E, Lettino, M, Vergani, P, Ornaghi, Sara, Bellante, Nicolo', Abbamondi, Alessandra, Maini, Marzia, Cesana, Francesca, Trabucchi, Margherita, Corsi, Davide, Arosio, Viola, Mariani, Silvana, Scian, Antonietta, Colciago, Elisabetta, Lettino, Maddalena, and Vergani, Patrizia

Abstract

Objective To appraise the application of the 2018 European Society of Cardiology-adapted modified WHO (mWHO) classification to pregnant women with heart disease managed at our maternal-fetal medicine referral centre and to assess whether the lack of a multidisciplinary Pregnancy Heart team has influenced their outcomes. Methods A retrospective cohort study including all pregnancies with heart disease managed at our centre between June 2011 and December 2020. Cardiac conditions were categorised in five classes according to the mWHO classification. An additional class, named X, was created for conditions not included in this classification. Outcomes were compared among all classes and factors potentially associated to cardiac complications were assessed. Results We identified 162 women with 197 pregnancies, for a prevalence of 0.7%. Thirty-eight (19.3%) gestations were included in class X. Caesarean section was performed in 64.9% pregnancies in class X, a rate similar to that of class II, II-III, and III/IV, and mostly for obstetric indications; in turn, it was more commonly performed for cardiology reasons in class II-III and III/IV. Cardiac complications occurred in 10.7%, with class X and II pregnancies showing the highest number of events (n=30.8% and 34.6%, respectively). Multiple gestation and urgent caesarean section associated with a 5-fold and 6.5-fold increase in complication rates. Conclusions Even in a maternal-fetal medicine referral centre, the lack of a multidisciplinary team approach to women with heart disease may negatively impact their outcomes.

Published
2022

14. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice

Author

Visseren, F. L. J., Mach, F., Smulders, Y. M., Carballo, D., Koskinas, K. C., Back, M., Benetos, A., Biffi, A., Boavida, J. -M., Capodanno, D., Cosyns, B., Crawford, C., Davos, C. H., Desormais, I., DI Angelantonio, E., Franco, O. H., Halvorsen, S., Hobbs, F. D. R., Hollander, M., Jankowska, E. A., Michal, M., Sacco, S., Sattar, N., Tokgozoglu, L., Tonstad, S., Tsioufis, K. P., Van DIs, I., Van Gelder, I. C., Wanner, C., Williams, B., De Backer, G., Regitz-Zagrosek, V., Aamodt, A. H., Abdelhamid, M., Aboyans, V., Albus, C., Asteggiano, R., Borger, M. A., Brotons, C., Ielutkiene, J., Cifkova, R., Cikes, M., Cosentino, F., Dagres, N., De Backer, T., De Bacquer, D., Delgado, V., Den Ruijter, H., Dendale, P., Drexel, H., Falk, V., Fauchier, L., Ference, B. A., Ferrieres, J., Ferrini, M., Fisher, M., Fliser, D., Fras, Z., Gaita, D., Giampaoli, S., Gielen, S., Graham, I., Jennings, C., Jorgensen, T., Kautzky-Willer, A., Kavousi, M., Koenig, W., Konradi, A., Kotecha, D., Landmesser, U., Lettino, M., Lewis, B. S., Linhart, A., Lochen, M. -L., Makrilakis, K., Mancia, G., Marques-Vidal, P., Mcevoy, J. W., Mcgreavy, P., Merkely, B., Neubeck, L., Nielsen, J. C., Perk, J., Petersen, S. E., Petronio, A. S., Piepoli, M., Pogosova, N. G., Prescott, E. I. B., Ray, K. K., Reiner, Z., Richter, D. J., Ryden, L., Shlyakhto, E., Sitges, M., Sousa-Uva, M., Sudano, I., Tiberi, M., Touyz, R. M., Ungar, A., Verschuren, W. M. M., Wiklund, O., Wood, D., Zamorano, J. L., Crawford, C. A., Franco Duran, O. H., Richard Hobbs, F. D., Dis, I. V., Group, ESC Scientific Document, Clinical sciences, Cardio-vascular diseases, and Cardiology

Subjects
medicine.medical_specialty, Epidemiology, Population, air pollution, population, Guidelines, blood pressure, climate change, diabetes, healthy lifestyle, lifetime benefit, lifetime risk, lipids, nutrition, personalized, prevention, psychosocial factors, risk estimation, risk management, shared decision-making, smoking, stepwise approach, Risk Assessment, Humans, Primary Prevention, Risk Factors, Cardiovascular Diseases, Diabetes mellitus, medicine, Intensive care medicine, education, 610 Medicine & health, Risk management, education.field_of_study, business.industry, medicine.disease, Clinical Practice, Blood pressure, guidelines, Heart failure, Lifetime risk, Disease prevention, Cardiology and Cardiovascular Medicine, business, Stepwise approach, 360 Social problems & social services
Abstract

These are the clinical practice guidelines from the European Society of Cardiology on cardiovascular disease prevention in clinical practice, from 2021.

Published
2022

15. European Society of Cardiology guidance for the diagnosis and management of cardiovascular disease during the COVID-19 pandemic: part 1-epidemiology, pathophysiology, and diagnosis The Task Force for the management of COVID-19 of the European Society of Cardiology

Author

Baigent, C., Windecker, S., Andreini, D., Arbelo, E., Barbato, E., Bartorelli, A.L., Baumbach, A., Behr, E.R., Berti, S., Bueno, H., Capodanno, D., Cappato, R., Chieffo, A., Collet, J.P., Cuisset, T., Simone, G. de, Delgado, V., Dendale, P., Dudek, D., Edvardsen, T., Elvan, A., Gonzalez-Juanatey, J.R., Gori, M., Grobbee, D., Guzik, T.J., Halvorsen, S., Haude, M., Heidbuchel, H., Hindricks, G., Ibanez, B., Karam, N., Katus, H., Klok, F.A., Konstantinides, S.V., Landmesser, U., Leclercq, C., Leonardi, S., Lettino, M., Marenzi, G., Mauri, J., Metra, M., Morici, N., Mueller, C., Petronio, A.S., Polovina, M.M., Potpara, T., Praz, F., Prendergast, B., Prescott, E., Price, S., Pruszczyk, P., Rodriguez-Leor, O., Roffi, M., Romaguera, R., Rosenkranz, S., Sarkozy, A., Scherrenberg, M., Seferovic, P., Senni, M., Spera, F.R., Stefanini, G., Thiele, H., Tomasoni, D., Torracca, L., Touyz, R.M., Wilde, A.A., Williams, B., and European Soc Cardiology

Subjects
Myocarditis, Myocardial injury, Non-invasive imaging, ACE2, COVID-19, Arrhythmias, Cardiogenic shock, Biomarkers
Abstract

Aims Since its emergence in early 2020, the novel severe acute respiratory syndrome coronavirus 2 causing coronavirus disease 2019 (COVID-19) has reached pandemic levels, and there have been repeated outbreaks across the globe. The aim of this two-part series is to provide practical knowledge and guidance to aid clinicians in the diagnosis and management of cardiovascular disease (CVD) in association with COVID-19.Methods and results A narrative literature review of the available evidence has been performed, and the resulting information has been organized into two parts. The first, reported here, focuses on the epidemiology, pathophysiology, and diagnosis of cardiovascular (CV) conditions that may be manifest in patients with COVID-19. The second part, which will follow in a later edition of the journal, addresses the topics of care pathways, treatment, and follow-up of CV conditions in patients with COVID-19.Conclusion This comprehensive review is not a formal guideline but rather a document that provides a summary of current knowledge and guidance to practicing clinicians managing patients with CVD and COVID-19. The recommendations are mainly the result of observations and personal experience from healthcare providers. Therefore, the information provided here may be subject to change with increasing knowledge, evidence from prospective studies, and changes in the pandemic. Likewise, the guidance provided in the document should not interfere with recommendations provided by local and national healthcare authorities.[GRAPHICS].

Published
2021

16. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes

Author

Knuuti, Juhani, Wijns, William, Saraste, Antti, Capodanno, Davide, Barbato, Emanuele, Funck-Brentano, Christian, Prescott, Eva, Storey, Robert F, Deaton, Christi, Cuisset, Thomas, Agewall, Stefan, Dickstein, Kenneth, Edvardsen, Thor, Escaned, Javier, Gersh, Bernard J, Svitil, Pavel, Gilard, Martine, Hasdai, David, Hatala, Robert, Mahfoud, Felix, Masip, Josep, Muneretto, Claudio, Valgimigli, Marco, Achenbach, Stephan, Bax, Jeroen J, Neumann FJ, Sechtem U, Banning AP, Bonaros N, Bueno H, Bugiardini R, Chieffo A, Crea F, Czerny M, Delgado V, Dendale P, Flachskampf FA, Gohlke H, Grove EL, James S, Katritsis D, Landmesser U, Lettino M, Matter CM, Nathoe H, Niessner A, Patrono C, Petronio AS, Pettersen SE, Piccolo R, Piepoli MF, Popescu BA, Räber L, Richter DJ, Roffi M, Roithinger FX, Shlyakhto E, Sibbing D, Silber S, Simpson IA, Sousa-Uva M, Vardas P, Witkowski A, Zamorano JL, Achenbach S, Agewall S, Barbato E, Bax JJ, Capodanno D, Cuisset T, Deaton C, Dickstein K, Edvardsen T, Escaned J, Funck-Brentano C, Gersh BJ, Gilard M, Hasdai D, Hatala R, Mahfoud F, Masip J, Muneretto C, Prescott E, Saraste A, Storey RF, Svitil P, Valgimigli M, Windecker S, Aboyans V, Baigent C, Collet JP, Dean V, Fitzsimons D, Gale CP, Grobbee D, Halvorsen S, Hindricks G, Iung B, Jüni P, Katus HA, Leclercq C, Lewis BS, Merkely B, Mueller C, Petersen S, Touyz RM, Benkhedda S, Metzler B, Sujayeva V, Cosyns B, Kusljugic Z, Velchev V, Panayi G, Kala P, Haahr-Pedersen SA, Kabil H, Ainla T, Kaukonen T, Cayla G, Pagava Z, Woehrle J, Kanakakis J, Tóth K, Gudnason T, Peace A, Aronson D, Riccio C, Elezi S, Mirrakhimov E, Hansone S, Sarkis A, Babarskiene R, Beissel J, Maempel AJC, Revenco V, de Grooth GJ, Pejkov H, Juliebø V, Lipiec P, Santos J, Chioncel O, Duplyakov D, Bertelli L, Dikic AD, Studenčan M, Bunc M, Alfonso F, Bäck M, Zellweger M, Addad F, Yildirir A, Sirenko Y, Clapp B, Sorbonne Université (SU), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de pharmacologie médicale [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Département de Cardiologie [Hôpital de la Timone - APHM], Hôpital de la Timone [CHU - APHM] (TIMONE)-Assistance Publique - Hôpitaux de Marseille (APHM), Knuuti, Juhani, Wijns, William, Saraste, Antti, Capodanno, Davide, Barbato, Emanuele, Funck-Brentano, Christian, Prescott, Eva, Storey, Robert F, Deaton, Christi, Cuisset, Thoma, Agewall, Stefan, Dickstein, Kenneth, Edvardsen, Thor, Escaned, Javier, Gersh, Bernard J, Svitil, Pavel, Gilard, Martine, Hasdai, David, Hatala, Robert, Mahfoud, Felix, Masip, Josep, Muneretto, Claudio, Valgimigli, Marco, Achenbach, Stephan, Bax, Jeroen J, Neumann FJ, Sechtem U, Banning AP, Bonaros N, Bueno H, Bugiardini R, Chieffo A, Crea F, Czerny M, Delgado V, Dendale P, Flachskampf FA, Gohlke H, Grove EL, James S, Katritsis D, Landmesser U, Lettino M, Matter CM, Nathoe H, Niessner A, Patrono C, Petronio AS, Pettersen SE, Piccolo R, Piepoli MF, Popescu BA, Räber L, Richter DJ, Roffi M, Roithinger FX, Shlyakhto E, Sibbing D, Silber S, Simpson IA, Sousa-Uva M, Vardas P, Witkowski A, Zamorano JL, Achenbach S, Agewall S, Barbato E, Bax JJ, Capodanno D, Cuisset T, Deaton C, Dickstein K, Edvardsen T, Escaned J, Funck-Brentano C, Gersh BJ, Gilard M, Hasdai D, Hatala R, Mahfoud F, Masip J, Muneretto C, Prescott E, Saraste A, Storey RF, Svitil P, Valgimigli M, Windecker S, Aboyans V, Baigent C, Collet JP, Dean V, Delgado V, Fitzsimons D, Gale CP, Grobbee D, Halvorsen S, Hindricks G, Iung B, Jüni P, Katus HA, Landmesser U, Leclercq C, Lettino M, Lewis BS, Merkely B, Mueller C, Petersen S, Petronio AS, Richter DJ, Roffi M, Shlyakhto E, Simpson IA, Sousa-Uva M, Touyz RM, Benkhedda S, Metzler B, Sujayeva V, Cosyns B, Kusljugic Z, Velchev V, Panayi G, Kala P, Haahr-Pedersen SA, Kabil H, Ainla T, Kaukonen T, Cayla G, Pagava Z, Woehrle J, Kanakakis J, Tóth K, Gudnason T, Peace A, Aronson D, Riccio C, Elezi S, Mirrakhimov E, Hansone S, Sarkis A, Babarskiene R, Beissel J, Maempel AJC, Revenco V, de Grooth GJ, Pejkov H, Juliebø V, Lipiec P, Santos J, Chioncel O, Duplyakov D, Bertelli L, Dikic AD, Studenčan M, Bunc M, Alfonso F, Bäck M, Zellweger M, Addad F, Yildirir A, Sirenko Y, Clapp B, Clinical sciences, Cardio-vascular diseases, Cardiology, Knuuti, Juhani [0000-0003-3156-9593], Apollo - University of Cambridge Repository, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), University of Zurich, Knuuti, J., Wijns, W., Achenbach, S., Agewall, S., Barbato, E., Bax, J. J., Capodanno, D., Cuisset, T., Deaton, C., Dickstein, K., Edvardsen, T., Escaned, J., Funck-Brentano, C., Gersh, B. J., Gilard, M., Hasdai, D., Hatala, R., Mahfoud, F., Masip, J., Muneretto, C., Prescott, E., Saraste, A., Storey, R. F., Svitil, P., Valgimigli, M., Windecker, S., Aboyans, V., Baigent, C., Collet, J. -P., Dean, V., Delgado, V., Fitzsimons, D., Gale, C. P., Grobbee, D. E., Halvorsen, S., Hindricks, G., Iung, B., Juni, P., Katus, H. A., Landmesser, U., Leclercq, C., Lettino, M., Lewis, B. S., Merkely, B., Mueller, C., Petersen, S., Petronio, A. S., Richter, D. J., Roffi, M., Shlyakhto, E., Simpson, I. A., Sousa-Uva, M., Touyz, R. M., Benkhedda, S., Metzler, B., Sujayeva, V., Cosyns, B., Kusljugic, Z., Velchev, V., Panayi, G., Kala, P., Haahr-Pedersen, S. A., Kabil, H., Ainla, T., Kaukonen, T., Cayla, G., Pagava, Z., Woehrle, J., Kanakakis, J., Toth, K., Gudnason, T., Peace, A., Aronson, D., Riccio, C., Elezi, S., Mirrakhimov, E., Hansone, S., Sarkis, A., Babarskiene, R., Beissel, J., Cassar Maempel, A. J., Revenco, V., de Grooth, G. J., Pejkov, H., Juliebo, V., Lipiec, P., Santos, J., Chioncel, O., Duplyakov, D., Bertelli, L., Dikic, A. D., Studencan, M., Bunc, M., Alfonso, F., Back, M., Zellweger, M., Addad, F., Yildirir, A., Sirenko, Y., and Clapp, B.

Subjects
anti-ischaemic drug, chronic coronary syndromes, medicine.medical_treatment, [SDV]Life Sciences [q-bio], lipid-lowering drugs, Diagnostic Techniques, Cardiovascular, antithrombotic therapy, Disease, 030204 cardiovascular system & hematology, Guideline, Coronary artery disease, 0302 clinical medicine, Disease management (health), Societies, Medical, ComputingMilieux_MISCELLANEOUS, chronic coronary syndrome, angina pectori, Disease Management, food and beverages, imaging, risk assessment, Syndrome, 3. Good health, Natural history, Europe, Cardiology, Cardiology and Cardiovascular Medicine, coronary artery disease, medicine.medical_specialty, lifestyle modifications, anti-ischaemic drugs, Ischemia, 610 Medicine & health, vasospastic angina, Guidelines, Revascularization, diagnostic testing, 11171 Cardiocentro Ticino, 2705 Cardiology and Cardiovascular Medicine, 03 medical and health sciences, angina pectoris, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Internal medicine, medicine, Journal Article, Humans, business.industry, screening, fungi, 030229 sport sciences, medicine.disease, lipid-lowering drug, Angina pectoris, Anti-ischaemic drugs, Antithrombotic therapy, Chronic coronary syndromes, Diagnostic testing, Imaging, Lifestyle modifications, Lipid-lowering drugs, Microvascular angina, Myocardial ischaemia, Myocardial revascularization, Risk assessment, Screening, Vasospastic angina, myocardial ischaemia, myocardial revascularization, Heart failure, microvascular angina, Chronic Disease, Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, lifestyle modification, Coronary Artery Disease/diagnosis, business, Fibrinolytic agent
Abstract

Coronary artery disease (CAD) is a pathological process characterized by atherosclerotic plaque accumulation in the epicardial arteries, whether obstructive or non-obstructive. This process can be modified by lifestyle adjustments, pharmacological therapies, and invasive interventions designed to achieve disease stabilization or regression. The disease can have long, stable periods but can also become unstable at any time, typically due to an acute atherothrombotic event caused by plaque rupture or erosion. However, the disease is chronic, most often progressive, and hence serious, even in clinically apparently silent periods. The dynamic nature of the CAD process results in various clinical presentations, which can be conveniently categorized as either acute coronary syndromes (ACS) or chronic coronary syndromes (CCS). The Guidelines presented here refer to the management of patients with CCS. The natural history of CCS is illustrated in Figure 1.

Published
2019

17. 2019 ESC Guidelines for themanagement of patients with supraventricular tachycardia

Author

Brugada, J., Katritsis, D. G., Arbelo, E., Arribas, F., Bax, J. J., Blomstrom-Lundqvist, C., Calkins, H., Corrado, D., Deftereos, S. G., Diller, G. -P., Gomez-Doblas, J. J., Gorenek, B., Grace, A., S. Y., Ho, Kaski, J. -C., Kuck, K. -H., Lambiase, P. D., Sacher, F., Sarquella-Brugada, G., Suwalski, P., Zaza, A., De Potter, T., Sticherling, C., Aboyans, V., Basso, C., Bocchiardo, M., Budts, W., Delgado, V., Dobrev, D., Fitzsimons, D., Gevaert, S., Heidbuchel, H., Hindricks, G., Hlivak, P., Kanagaratnam, P., Katus, H., Kautzner, J., Kriebel, T., Lancellotti, P., Landmesser, U., Leclercq, C., Lewis, B., Lopatin, Y., Merkely, B., Paul, T., Pavlovic, N., Petersen, S., Petronio, A. S., Potpara, T., Roffi, M., Scherr, D., Shlyakhto, E., Simpson, I. A., Zeppenfeld, K., Windecker, S., Baigent, C., Collet, J. -P., Dean, V., Gale, C. P., Grobbee, D. E., Halvorsen, S., Iung, B., Juni, P., Lettino, M., Mueller, C., Richter, D. J., Sousa-Uva, M., Touyz, R. M., Amara, W., Grigoryan, S., Podczeck-Schweighofer, A., Chasnoits, A., Vandekerckhove, Y., Sokolovich, S., Traykov, V., Skoric, B., Papasavvas, E., Riahi, S., Kampus, P., Parikka, H., Piot, O., Etsadashvili, K., Stellbrink, C., Manolis, A. S., Csanadi, Z., Gudmundsson, K., Erwin, J., Barsheshet, A., De Ponti, R., Abdrakhmanov, A., Jashari, H., Lunegova, O., Jubele, K., Refaat, M. M., Puodziukynas, A., Groben, L., Grosu, A., Ibtissam, F., Trines, S. A., Poposka, L., Haugaa, K. H., Kowalski, O., Cavaco, D., Dobreanu, D., Mikhaylov, E. N., Zavatta, M., Nebojsa, M., Ferreira-Gonzalez, I., Juhlin, T., Reichlin, T., Haouala, H., Akgun, T., Gupta, D., Brugada, J, Katritsis, D, Arbelo, E, Arribas, F, Bax, J, Blomstrom-Lundqvist, C, Calkins, H, Corrado, D, Deftereos, S, Diller, G, Gomez-Doblas, J, Gorenek, B, Grace, A, Ho, S, Kaski, J, Kuck, K, Lambiase, P, Sacher, F, Sarquella-Brugada, G, Suwalski, P, Zaza, A, De Potter, T, Sticherling, C, Aboyans, V, Basso, C, Bocchiardo, M, Budts, W, Delgado, V, Dobrev, D, Fitzsimons, D, Gevaert, S, Heidbuchel, H, Hindricks, G, Hlivak, P, Kanagaratnam, P, Katus, H, Kautzner, J, Kriebel, T, Lancellotti, P, Landmesser, U, Leclercq, C, Lewis, B, Lopatin, Y, Merkely, B, Paul, T, Pavlovic, N, Petersen, S, Petronio, A, Potpara, T, Roffi, M, Scherr, D, Shlyakhto, E, Simpson, I, Zeppenfeld, K, Windecker, S, Baigent, C, Collet, J, Dean, V, Gale, C, Grobbee, D, Halvorsen, S, Iung, B, Juni, P, Lettino, M, Mueller, C, Richter, D, Sousa-Uva, M, Touyz, R, Amara, W, Grigoryan, S, Podczeck-Schweighofer, A, Chasnoits, A, Vandekerckhove, Y, Sokolovich, S, Traykov, V, Skoric, B, Papasavvas, E, Riahi, S, Kampus, P, Parikka, H, Piot, O, Etsadashvili, K, Stellbrink, C, Manolis, A, Csanadi, Z, Gudmundsson, K, Erwin, J, Barsheshet, A, De Ponti, R, Abdrakhmanov, A, Jashari, H, Lunegova, O, Jubele, K, Refaat, M, Puodziukynas, A, Groben, L, Grosu, A, Ibtissam, F, Trines, S, Poposka, L, Haugaa, K, Kowalski, O, Cavaco, D, Dobreanu, D, Mikhaylov, E, Zavatta, M, Nebojsa, M, Ferreira-Gonzalez, I, Juhlin, T, Reichlin, T, Haouala, H, Akgun, T, and Gupta, D

Subjects
Focal, Supraventricular, Atrioventricular, Nodal, Guidelines, Ablation, Flutter, Guideline, Tachycardia, Re-entrant, Arrhythmia, Junctional, Macrore-entrant, Pre-excitation
Abstract

E' una "linea-guida" non esiste abstract.

Published
2020

18. Appropriateness criteria for the management of lipid-lowering therapy with alirocumab in high cardiovascular risk patients. The opinion of a multidisciplinary group of Italian experts

Author

Lettino, M., Zambon, A., Musumeci, G., Arca, M., Bilato, C., Brunetti, N. D., Calabro, P., Casu, G., Chiarella, F., Faggiano, P., Ferlini, M., Guardigli, G., Imbalzano, E., Indolfi, C., Marcucci, R., Menozzi, A., Mureddu, G. F., Filardi, P. P., Pirro, M., Pisciotta, L., Scherillo, M., Suppressa, P., Uguccioni, M., Varbella, F., Gentile, L., Rapezzi, C., Averna, M., Lettino, Maddalena, Zambon, Alberto, Musumeci, Giuseppe, Arca, Marcello, Bilato, Claudio, Brunetti, Natale Daniele, Calabrò, Paolo, Casu, Gavino, Chiarella, Francesco, Faggiano, Pompilio, Ferlini, Marco, Guardigli, Gabriele, Imbalzano, Egidio, Indolfi, Ciro, Marcucci, Rossella, Menozzi, Alberto, Mureddu, Gian Francesco, Filardi, Pasquale Perrone, Pirro, Matteo, Pisciotta, Livia, Scherillo, Marino, Suppressa, Patrizia, Uguccioni, Massimo, Varbella, Ferdinando, Gentile, Luigi, Rapezzi, Claudio, Averna, Maurizio, Lettino M., Zambon A., Musumeci G., Arca M., Bilato C., Brunetti N.D., Calabro P., Casu G., Chiarella F., Faggiano P., Ferlini M., Guardigli G., Imbalzano E., Indolfi C., Marcucci R., Menozzi A., Mureddu G.F., Filardi P.P., Pirro M., Pisciotta L., Scherillo M., Suppressa P., Uguccioni M., Varbella F., Gentile L., Rapezzi C., and Averna M.

Subjects
Settore MED/09 - Medicina Interna, Consensus, PCSK9 inhibitor, Familial hypercholesterolemia, Hypercholesterolemia, Antibodies, Monoclonal, Humanized, Anticholesteremic Agents, Atherosclerosis, Cholesterol, LDL, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Italy, Risk Assessment, Risk Factors, Cardiovascular Diseases, Consensu, Antibodies, LDL, Acute coronary syndrome, Alirocumab, Cardiovascular risk, PCSK9 inhibitors, Anticholesteremic Agent, Monoclonal, Humanized, Cholesterol, Atherosclerosi
Abstract

High levels of LDL cholesterol (LDL-C) represent a causal factor for cardiovascular diseases on an atherosclerotic basis, with a direct correlation between these and mortality or cardiovascular events, such that the reduction of both is associated proportionally and linearly with the reduction of LDL-C.Statins and ezetimibe are used for LDL-C lowering but may not be sufficient to achieve the targets defined by the ESC/EAS guidelines, which recommend use of PCSK9 inhibitors for further LDL-C reduction in patients not at goal.This project submitted 86 clinical scenarios to a group of experts, cardiologists, internists and lipidologists, collecting their opinion on the appropriateness of different behaviors and decisions. We used the RAND/UCLA method of assessing the appropriateness of clinical interventions, validated to combine the best scientific evidence available with expert judgment. To this end, the benefit-risk ratio was evaluated in the proposed clinical scenarios. Each indication was classified as "appropriate", "uncertain" or "inappropriate" based on the average score given by the participants.This document presents the results of a consensus process that led to the development of recommendations for the management of clinical scenarios on the treatment of patients with dyslipidemia, which cannot always be solved with scientific evidence alone.

Published
2020

19. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)

Author

Hindricks, G., primary, Potpara, T., additional, Dagres, N., additional, Arbelo, E., additional, Bax, J. J., additional, Blomstrӧm-Lundqvist, C., additional, Boriani, G., additional, Castella, M., additional, Dan, G.-A., additional, Dilaveris, P. E., additional, Fauchier, L., additional, Filippatos, G., additional, Kalman, J. M., additional, La Meir, M., additional, Lane, D. A., additional, Lebeau, J.-P., additional, Lettino, M., additional, Lip, G. Y.H., additional, Pinto, F. J., additional, Neil Thomas, G., additional, Valgimigli, M., additional, Van Gelder, I. C., additional, Van Putte,, B. P., additional, and Watkins, C. L., additional

Published
2021
Full Text
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20. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation, developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC), developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC

Author

Hindricks, G., Potpara, T., Dagres, N., Arbelo, E., Bax, J. J., Blomstrom-Lundqvist, C., Boriani, G., Castella, M., Dan, G. -A., Dilaveris, P. E., Fauchier, L., Filippatos, G., Kalman, J. M., Meir, M. L., Lane, D. A., Lebeau, J. -P., Lettino, M., Lip, G. Y. H., Pinto, F. J., Neil Thomas, G., Valgimigli, M., Van Gelder, I. C., Van Putte, B. P., and Watkins, C. L.

Published
2021

21. Current status and needs for changes in critical care training: the voice of the young cardiologists

Author

Czerwinska-Jelonkiewicz, K, Montero, S, Baneras, J, Wood, A, Zeid, A, De Rosa, S, Guerra, F, Tica, O, Serrano, F, Bohm, A, Ahrens, I, Gierlotka, M, Masip, J, Bonnefoy, E, Lettino, M, Kirchhof, P, and Sionis, A

Subjects
Gender disparities in training, Simulation-based learning, Acute cardiovascular care training, Critical care training, Cardiology training, Leadership training
Abstract

Aims The implementation of the 2013 European Society of Cardiology (ESC) Core Curriculum guidelines for acute cardiovascular care (acc) training among European countries is unknown. We aimed to evaluate the current status of acc training among cardiology trainees and young cardiologists (

Published
2021

22. 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation

Author

Collet, J. -P., Thiele, H., Barbato, E., Bauersachs, J., Dendale, P., Edvardsen, T., Gale, C. P., Jobs, A., Lambrinou, E., Mehilli, J., Merkely, B., Roffi, M., Sibbing, D., Kastrati, A., Mamas, M. A., Aboyans, V., Angiolillo, D. J., Bueno, H., Bugiardini, R., Byrne, R. A., Castelletti, S., Chieffo, A., Cornelissen, V., Crea, Filippo, Delgado, V., Drexel, H., Gierlotka, M., Halvorsen, S., Haugaa, K. H., Jankowska, E. A., Katus, H. A., Kinnaird, T., Kluin, J., Kunadian, V., Landmesser, U., Leclercq, C., Lettino, M., Meinila, L., Mylotte, D., Ndrepepa, G., Omerovic, E., Pedretti, R. F. E., Petersen, S. E., Petronio, A. S., Pontone, G., Popescu, B. A., Potpara, T., Ray, K. K., Luciano, F., Richter, D. J., Shlyakhto, E., Simpson, I. A., Sousa-Uva, M., Storey, R. F., Touyz, R. M., Valgimigli, M., Vranckx, P., Yeh, R. W., Barthelemy, O., Bhatt, D. L., Dorobantu, M., Folliguet, T., Gilard, M., Juni, P., Lewis, B. S., Meliga, E., Mueller, C., Rutten, F. H., Siontis, G. C. M., Crea F. (ORCID:0000-0001-9404-8846), Collet, J. -P., Thiele, H., Barbato, E., Bauersachs, J., Dendale, P., Edvardsen, T., Gale, C. P., Jobs, A., Lambrinou, E., Mehilli, J., Merkely, B., Roffi, M., Sibbing, D., Kastrati, A., Mamas, M. A., Aboyans, V., Angiolillo, D. J., Bueno, H., Bugiardini, R., Byrne, R. A., Castelletti, S., Chieffo, A., Cornelissen, V., Crea, Filippo, Delgado, V., Drexel, H., Gierlotka, M., Halvorsen, S., Haugaa, K. H., Jankowska, E. A., Katus, H. A., Kinnaird, T., Kluin, J., Kunadian, V., Landmesser, U., Leclercq, C., Lettino, M., Meinila, L., Mylotte, D., Ndrepepa, G., Omerovic, E., Pedretti, R. F. E., Petersen, S. E., Petronio, A. S., Pontone, G., Popescu, B. A., Potpara, T., Ray, K. K., Luciano, F., Richter, D. J., Shlyakhto, E., Simpson, I. A., Sousa-Uva, M., Storey, R. F., Touyz, R. M., Valgimigli, M., Vranckx, P., Yeh, R. W., Barthelemy, O., Bhatt, D. L., Dorobantu, M., Folliguet, T., Gilard, M., Juni, P., Lewis, B. S., Meliga, E., Mueller, C., Rutten, F. H., Siontis, G. C. M., and Crea F. (ORCID:0000-0001-9404-8846)

Abstract

N/A

Published
2021

23. A Multidisciplinary Approach on the Perioperative Antithrombotic Management of Patients With Coronary Stents Undergoing Surgery: Surgery After Stenting 2

Author

Rossini, R, Tarantini, G, Musumeci, G, Masiero, G, Barbato, E, Calabrò, P, Capodanno, D, Leonardi, S, Lettino, M, Limbruno, U, Menozzi, A, Marchese, U, Saia, F, Valgimigli, M, Ageno, W, Falanga, A, Corcione, A, Locatelli, A, Montorsi, M, Piazza, D, Stella, A, Bozzani, A, Parolari, A, Carone, R, Angiolillo, D, Rossini R, Tarantini G, Musumeci G, Masiero G, Barbato E, Calabrò P, Capodanno D, Leonardi S, Lettino M, Limbruno U, Menozzi A, Marchese UOA, Saia F, Valgimigli M, Ageno W, Falanga A, Corcione A, Locatelli A, Montorsi M, Piazza D, Stella A, Bozzani A, Parolari A, Carone R, Angiolillo DJ, Rossini, R, Tarantini, G, Musumeci, G, Masiero, G, Barbato, E, Calabrò, P, Capodanno, D, Leonardi, S, Lettino, M, Limbruno, U, Menozzi, A, Marchese, U, Saia, F, Valgimigli, M, Ageno, W, Falanga, A, Corcione, A, Locatelli, A, Montorsi, M, Piazza, D, Stella, A, Bozzani, A, Parolari, A, Carone, R, Angiolillo, D, Rossini R, Tarantini G, Musumeci G, Masiero G, Barbato E, Calabrò P, Capodanno D, Leonardi S, Lettino M, Limbruno U, Menozzi A, Marchese UOA, Saia F, Valgimigli M, Ageno W, Falanga A, Corcione A, Locatelli A, Montorsi M, Piazza D, Stella A, Bozzani A, Parolari A, Carone R, and Angiolillo DJ

Abstract

Perioperative management of antithrombotic therapy in patients treated with coronary stents undergoing surgery remains poorly defined. Importantly, surgery represents a common reason for premature treatment discontinuation, which is associated with an increased risk in mortality and major adverse cardiac events. However, maintaining antithrombotic therapy to minimize the incidence of perioperative ischemic complications may increase the risk of bleeding complications. Although guidelines provide some recommendations with respect to the perioperative management of antithrombotic therapy, these have been largely developed according to the thrombotic risk of the patient and a definition of the hemorrhagic risk specific to each surgical procedure, key to defining the trade-off between ischemia and bleeding, is not provided. These observations underscore the need for a multidisciplinary collaboration among cardiologists, anesthesiologists, hematologists and surgeons to reach this goal. The present document is an update on practical recommendations for standardizing management of antithrombotic therapy management in patients treated with coronary stents (Surgery After Stenting 2) in various types of surgery according to the predicted individual risk of thrombotic complications against the anticipated risk of surgical bleeding complications. Cardiologists defined the thrombotic risk using a “combined ischemic risk” approach, while surgeons classified surgeries according to their inherent hemorrhagic risk. Finally, a multidisciplinary agreement on the most appropriate antithrombotic treatment regimen in the perioperative phase was reached for each surgical procedure.

Published
2018

24. Clinical Practice Guides ESC 2019 guide on diabetes, prediabetes and cardiovascular disease, in collaboration with the European Association for the Study of Diabetes (EASD)

Author

Cosentino, F., Grant, P.J., Aboyans, V., Bailey, C.J., Ceriello, A., Delgado, V., Federici, M., Filippatos, G., Grobbee, D.E., Hansen, T.B., Huikuri, H.V., Johansson, I., Juni, P., Lettino, M., Marx, N., Mellbin, L.G., Ostgren, C.J., Rocca, B., Roffi, M., Sattar, N., Seferovic, P.M., Sousa-Uva, M., Valensi, P., Wheeler, D.C., Grp Trabajo Diabet Prediabet Enfer, and European Assoc Study Diabet EASD

Published
2020

25. 2019 ESC/EAS Guidelines for the management of dyslipidaemias

Author

Mach, F., Baigent, C., Catapano, A.L., Koskinas, K.C., Casula, M., Badimon, L., Chapman, M.J., Backer, G.G. de, Delgado, V., Ference, B.A., Graham, I.M., Halliday, A., Landmesser, U., Mihaylova, B., Pedersen, T.R., Riccardi, G., Richter, D.J., Sabatine, M.S., Taskinen, M.R., Tokgozoglu, L., Wiklund, O., Nibouche, D., Zelveian, P.H., Siostrzonek, P., Najafov, R., Borne, P. van de, Pojskic, B., Postadzhiyan, A., Kypris, L., Spinar, J., Larsen, M.L., Eldin, H.S., Viigimaa, M., Strandberg, T.E., Ferrieres, J., Agladze, R., Laufs, U., Rallidis, L., Bajnok, L., Gudjonsson, T., Maher, V., Henkin, Y., Gulizia, M.M., Mussagaliyeva, A., Bajraktari, G., Kerimkulova, A., Latkovskis, G., Hamoui, O., Slapikas, R., Visser, L., Dingli, P., Ivanov, V., Boskovic, A., Nazzi, M., Visseren, F., Mitevska, I., Retterstol, K., Jankowski, P., Fontes-Carvalho, R., Gaita, D., Ezhov, M., Foscoli, M., Giga, V., Pella, D., Fras, Z., Isla, L.P. de, Hagstrom, E., Lehmann, R., Abid, L., Ozdogan, O., Mitchenko, O., Patel, R.S., Windecker, S., Aboyans, V., Collet, J.P., Dean, V., Fitzsimons, D., Gale, C.P., Grobbee, D., Halvorsen, S., Hindricks, G., Iung, B., Juni, P., Katus, H.A., Leclercq, C., Lettino, M., Lewis, B.S., Merkely, B., Mueller, C., Petersen, S., Petronio, A.S., Roffi, M., Shlyakhto, E., Simpson, I.A., Sousa-Uva, M., Touyz, R.M., Task Force Members, ESC Natl Cardiac Soc, and ESC Committee Practice Guidelines

Published
2020

26. 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD

Author

Cosentino, F., Grant, P. J., Aboyans, V., Bailey, C. J., Ceriello, A., Delgado, V., Federici, M., Filippatos, G., Grobbee, D. E., Hansen, T. B., Huikuri, H. V., Johansson, I., Juni, P., Lettino, M., Marx, N., Mellbin, L. G., Ostgren, C. J., Rocca, Bianca, Roffi, M., Sattar, N., Seferovic, P. M., Sousa-Uva, M., Valensi, P., Wheeler, D. C., Piepoli, M. F., Birkeland, K. I., Adamopoulos, S., Ajjan, R., Avogaro, A., Baigent, C., Brodmann, M., Bueno, H., Ceconi, C., Chioncel, O., Coats, A., Collet, J. -P., Collins, P., Cosyns, B., Di Mario, C., Fisher, M., Fitzsimons, D., Halvorsen, S., Hansen, D., Hoes, A., Holt, R. I. G., Home, P., Katus, H. A., Khunti, K., Komajda, M., Lambrinou, E., Landmesser, U., Lewis, B. S., Linde, C., Lorusso, R., Mach, F., Mueller, C., Neumann, F. -J., Persson, F., Petersen, S. E., Petronio, A. S., Richter, D. J., Rosano, G. M. C., Rossing, P., Ryden, L., Shlyakhto, E., Simpson, I. A., Touyz, R. M., Wijns, W., Wilhelm, M., Williams, B., Windecker, S., Dean, V., Gale, C. P., Hindricks, G., Iung, B., Leclercq, C., Merkely, B., Zelveian, P. H., Scherr, D., Jahangirov, T., Lazareva, I., Shivalkar, B., Naser, N., Gruev, I., Milicic, D., Petrou, P. M., Linhart, A., Hildebrandt, P., Hasan-Ali, H., Marandi, T., Lehto, S., Mansourati, J., Kurashvili, R., Siasos, G., Lengyel, C., Thrainsdottir, I. S., Aronson, D., Di Lenarda, A., Raissova, A., Ibrahimi, P., Abilova, S., Trusinskis, K., Saade, G., Benlamin, H., Petrulioniene, Z., Banu, C., Magri, C. J., David, L., Boskovic, A., Alami, M., Liem, A. H., Bosevski, M., Svingen, G. F. T., Janion, M., Gavina, C., Vinereanu, D., Nedogoda, S., Mancini, T., Ilic, M. D., Fabryova, L., Fras, Z., Jimenez-Navarro, M. F., Norhammar, A., Lehmann, R., Mourali, M. S., Ural, D., Nesukay, E., Chowdhury, T. A., Clinical sciences, Cardio-vascular diseases, Cardiology, Human Physiology and Special Physiology of Physical Education, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), University of Zurich, and Cosentino, Francesco

Subjects
Settore MED/09 - Medicina Interna, Epidemiology, [SDV]Life Sciences [q-bio], 10265 Clinic for Endocrinology and Diabetology, Psychological intervention, Disease, Impaired glucose tolerance, Diabetes mellitus, Health care, risk factors, Guidelines, cardiovascular diseases, cardiovascular risk assessment, diabetes mellitus, epidemiology, impaired glucose tolerance, patient management, patient-centred care, pharmacological treatment, prevention, revascularization, Prediabetes, ComputingMilieux_MISCELLANEOUS, Societies, Medical, ddc:616, Cardiovascular risk assessment, 3. Good health, Europe, Cardiovascular diseases, Pre diabetes, Practice Guidelines as Topic, Cardiology and Cardiovascular Medicine, Pharmacological treatment, medicine.medical_specialty, Patient management, Patient-centred care, Prevention, Revascularization, Risk factors, Settore BIO/14 - FARMACOLOGIA, Cardiology, 610 Medicine & health, 2705 Cardiology and Cardiovascular Medicine, Prediabetic State, medicine, Humans, business.industry, medicine.disease, Diabetes Mellitus, Type 2, Family medicine, business
Abstract

This is the second iteration of the European Society of Cardiology (ESC) and European Association for the Study of Diabetes (EASD) joining forces to write guidelines on the management of diabetes mellitus (DM), pre-diabetes, and cardiovascular disease (CVD), designed to assist clinicians and other healthcare workers to make evidence-based management decisions. The growing awareness of the strong biological relationship between DM and CVD rightly prompted these two large organizations to collaborate to generate guidelines relevant to their joint interests, the first of which were published in 2007. Some assert that too many guidelines are being produced but, in this burgeoning field, five years in the development of both basic and clinical science is a long time and major trials have reported in this period, making it necessary to update the previous Guidelines.

Published
2020

27. 2019 ESC Guidelines for themanagement of patients with supraventricular tachycardia

Author

Brugada, J. Katritsis, D.G. Arbelo, E. Arribas, F. Bax, J.J. Blomstrom-Lundqvist, C. Calkins, H. Corrado, D. Deftereos, S.G. Diller, G.-P. Gomez-Doblas, J.J. Gorenek, B. Grace, A. Ho, S.Y. Kaski, J.-C. Kuck, K.-H. Lambiase, P.D. Sacher, F. Sarquella-Brugada, G. Suwalski, P. Zaza, A. De Potter, T. Sticherling, C. Aboyans, V. Basso, C. Bocchiardo, M. Budts, W. Delgado, V. Dobrev, D. Fitzsimons, D. Gevaert, S. Heidbuchel, H. Hindricks, G. Hlivak, P. Kanagaratnam, P. Katus, H. Kautzner, J. Kriebel, T. Lancellotti, P. Landmesser, U. Leclercq, C. Lewis, B. Lopatin, Y. Merkely, B. Paul, T. Pavlović, N. Petersen, S. Petronio, A.S. Potpara, T. Roffi, M. Scherr, D. Shlyakhto, E. Simpson, I.A. Zeppenfeld, K. Windecker, S. Baigent, C. Collet, J.-P. Dean, V. Gale, C.P. Grobbee, D.E. Halvorsen, S. Iung, B. Jüni, P. Lettino, M. Mueller, C. Richter, D.J. Sousa-Uva, M. Touyz, R.M. Amara, W. Grigoryan, S. Podczeck-Schweighofer, A. Chasnoits, A. Vandekerckhove, Y. Sokolovich, S. Traykov, V. Skoric, B. Papasavvas, E. Riahi, S. Kampus, P. Parikka, H. Piot, O. Etsadashvili, K. Stellbrink, C. Manolis, A.S. Csanádi, Z. Gudmundsson, K. Erwin, J. Barsheshet, A. De Ponti, R. Abdrakhmanov, A. Jashari, H. Lunegova, O. Jubele, K. Refaat, M.M. Puodziukynas, A. Groben, L. Grosu, A. Ibtissam, F. Trines, S.A. Poposka, L. Haugaa, K.H. Kowalski, O. Cavaco, D. Dobreanu, D. Mikhaylov, E.N. Zavatta, M. Nebojša, M. Ferreira-Gonzalez, I. Juhlin, T. Reichlin, T. Haouala, H. Akgun, T. Gupta, D. The Task Force for the management of patients with supraventricular tachycardia of the European Society of Cardiology (ESC), Association for European Paediatric Congenital Cardiology (AEPC)

Published
2020

28. Organization of intensive cardiac care units in Europe : Results of a multinational survey

Author

Claeys, M. J., Roubille, F., Casella, G., Zukermann, R., Nikolaou, N., De Luca, L., Gierlotkaa, M., Iakobishvili, Z., Thiele, H., Koutouzis, M., Sionis, A., Monteiro, S., Beauloye, C., Held, Claes, Tint, D., Zakke, I, Serpytis, P., Babic, Z., Belohlavev, J., Magdy, A., Rasalingam, M. Sivagowry, Daly, K., Arroyo, D., Vavlukis, M., Radovanovic, N., Trendafilova, E., Marandi, T., Hassenger, C., Lettino, M., Price, S., Bonnefoy, E., Claeys, M. J., Roubille, F., Casella, G., Zukermann, R., Nikolaou, N., De Luca, L., Gierlotkaa, M., Iakobishvili, Z., Thiele, H., Koutouzis, M., Sionis, A., Monteiro, S., Beauloye, C., Held, Claes, Tint, D., Zakke, I, Serpytis, P., Babic, Z., Belohlavev, J., Magdy, A., Rasalingam, M. Sivagowry, Daly, K., Arroyo, D., Vavlukis, M., Radovanovic, N., Trendafilova, E., Marandi, T., Hassenger, C., Lettino, M., Price, S., and Bonnefoy, E.

Abstract

Background: The present survey aims to describe the intensive cardiac care unit organization and admission policies in Europe. Methods: A total of 228 hospitals (61% academic) from 27 countries participated in this survey. In addition to the organizational aspects of the intensive cardiac care units, including classification of the intensive cardiac care unit levels, data on the admission diagnoses were gathered from consecutive patients who were admitted during a two-day period. Admission policies were evaluated by comparing illness severity with the intensive cardiac care unit level. Gross national income was used to differentiate high-income countries (n=13) from middle-income countries (n=14). Results: A total of 98% of the hospitals had an intensive cardiac care unit: 70% had a level 1 intensive cardiac care unit, 76% had a level 2 intensive cardiac care unit, 51% had a level 3 intensive cardiac care unit, and 60% of the hospitals had more than one intensive cardiac care unit level. High-income countries tended to have more level 3 intensive cardiac care units than middle-income countries (55% versus 41%, p=0.07). A total of 5159 admissions were scored on illness severity: 63% were low severity, 24% were intermediate severity, and 12% were high severity. Patients with low illness severity were predominantly admitted to level 1 intensive cardiac care units, whereas patients with high illness severity were predominantly admitted to level 2 and 3 intensive cardiac care units. A policy mismatch was observed in 12% of the patients; some patients with high illness severity were admitted to level 1 intensive cardiac care units, which occurred more often in middle-income countries, whereas some patients with low illness severity were admitted to level 3 intensive cardiac care units, which occurred more frequently in high-income countries. Conclusion: More than one-third of the admitted patients were considered intermediate or high risk. Although patients with higher il

Published
2020
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29. Organization of intensive cardiac care units in Europe: Results of a multinational survey

Author

Claeys, MJ, primary, Roubille, F, additional, Casella, G, additional, Zukermann, R, additional, Nikolaou, N, additional, De Luca, L, additional, Gierlotka, M, additional, Iakobishvili, Z, additional, Thiele, H, additional, Koutouzis, M, additional, Sionis, A, additional, Monteiro, S, additional, Beauloye, C, additional, Held, C, additional, Tint, D, additional, Zakke, I, additional, Serpytis, P, additional, Babic, Z, additional, Belohlavev, J, additional, Magdy, A, additional, Sivagowry Rasalingam, M, additional, Daly, K, additional, Arroyo, D, additional, Vavlukis, M, additional, Radovanovic, N, additional, Trendafilova, E, additional, Marandi, T, additional, Hassenger, C, additional, Lettino, M, additional, Price, S, additional, and Bonnefoy, E, additional

Published
2020
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30. Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds/Leeds Teaching Hospitals NHS Trust, LIGHT Laboratories, Clarendon Way

Author

Cosentino, F., primary, Grant, P. J., additional, Aboyans, V., additional, Bailey, G. J., additional, Ceriello, А., additional, Delgado, V., additional, Federici, M., additional, Filippatos, G., additional, Grobbee, D. E., additional, Hansen, T. В., additional, Huikuri, H. V., additional, Johansson, I., additional, Jüni, P., additional, Lettino, M., additional, Marx, N., additional, Mellbin, L. G., additional, Östgren, C. J., additional, Rocca, B., additional, Roffi, M., additional, Sattar, N., additional, Seferović, P. M., additional, Sousa-Uva, M., additional, Valensi, P., additional, and Wheeler, D. C., additional

Published
2020
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31. 2017 ESC update on dual antiplatelet therapy in coronary disease developed in collaboration with the EACTS

Author

Valgimigli A. D. G. D. T. M., Bueno H., Byrne R. A., Collet J. -P., Costa F., Jeppsson A., Juni P., Kastrati A., Kolh P., Mauri L., Montalescot G., Neumann F. -J., Petricevic M., Roffi M., Steg P. G., Windecker S., Zamorano J. L., Levine C. A. G. N., Badimon R. D. D. L., Vranckx P., Agewall S., Andreotti F., Antman E., Barbato E., Bassand J. -P., Bugiardini R., Cikirikcioglu M., Cuisset T., De Bonis M., Delgado V., Fitzsimons D., Gaemperli O., Galie N., Gilard M., Hamm C. W., Ibanez B., Iung B., James S., Knuuti J., Landmesser U., Leclercq C., Lettino M., Lip G., Piepoli M. F., Pierard L., Schwerzmann M., Sechtem U., Simpson I. A., Uva M. S., Stabile E., Storey R. F., Tendera M., Van de Werf F., Verheugt F., Aboyans V., Valgimigli, A. D. G. D. T. M., Bueno, H., Byrne, R. A., Collet, J. -P., Costa, F., Jeppsson, A., Juni, P., Kastrati, A., Kolh, P., Mauri, L., Montalescot, G., Neumann, F. -J., Petricevic, M., Roffi, M., Steg, P. G., Windecker, S., Zamorano, J. L., Levine, C. A. G. N., Badimon, R. D. D. L., Vranckx, P., Agewall, S., Andreotti, F., Antman, E., Barbato, E., Bassand, J. -P., Bugiardini, R., Cikirikcioglu, M., Cuisset, T., De Bonis, M., Delgado, V., Fitzsimons, D., Gaemperli, O., Galie, N., Gilard, M., Hamm, C. W., Ibanez, B., Iung, B., James, S., Knuuti, J., Landmesser, U., Leclercq, C., Lettino, M., Lip, G., Piepoli, M. F., Pierard, L., Schwerzmann, M., Sechtem, U., Simpson, I. A., Uva, M. S., Stabile, E., Storey, R. F., Tendera, M., Van de Werf, F., Verheugt, F., and Aboyans, V.

Published
2018

33. A Multidisciplinary Approach on the Perioperative Antithrombotic Management of Patients With Coronary Stents Undergoing Surgery: Surgery After Stenting 2

Author

Rossini, R., Tarantini, G., Musumeci, G., Masiero, G., Barbato, E., Calabro, P., Capodanno, D., Leonardi, S., Lettino, M., Limbruno, U., Menozzi, A., Marchese, U. O. A., Saia, F., Valgimigli, M., Ageno, W., Falanga, A., Corcione, A., Locatelli, A., Montorsi, M., Piazza, D., Stella, A., Bozzani, A., Parolari, A., Carone, R., Angiolillo, D. J., Rossini, Roberta, Tarantini, Giuseppe, Musumeci, Giuseppe, Masiero, Giulia, Barbato, Emanuele, Calabrò, Paolo, Capodanno, Davide, Leonardi, Sergio, Lettino, Maddalena, Limbruno, Ugo, Menozzi, Alberto, Marchese, U. O. Alfredo, Saia, Francesco, Valgimigli, Marco, Ageno, Walter, Falanga, Anna, Corcione, Antonio, Locatelli, Alessandro, Montorsi, Marco, Piazza, Diego, Stella, Andrea, Bozzani, Antonio, Parolari, Alessandro, Carone, Roberto, Angiolillo, Dominick J., Rossini, R, Tarantini, G, Musumeci, G, Masiero, G, Barbato, E, Calabrò, P, Capodanno, D, Leonardi, S, Lettino, M, Limbruno, U, Menozzi, A, Marchese, U, Saia, F, Valgimigli, M, Ageno, W, Falanga, A, Corcione, A, Locatelli, A, Montorsi, M, Piazza, D, Stella, A, Bozzani, A, Parolari, A, Carone, R, and Angiolillo, D

Subjects
Time Factors, Clinical Decision-Making, Blood Loss, Surgical, Coronary Artery Disease, Postoperative Hemorrhage, Coronary Angiography, anticoagulant therapy, antiplatelet therapy, atrial fibrillation, bleeding, stent, surgery, thrombosis, Cardiology and Cardiovascular Medicine, Risk Assessment, Drug Administration Schedule, Perioperative Care, Percutaneous Coronary Intervention, Fibrinolytic Agents, Risk Factors, thrombosi, Humans, Patient Care Team, Coronary Thrombosis, Anticoagulants, Treatment Outcome, Surgical Procedures, Operative, Stents, Platelet Aggregation Inhibitors
Abstract

Perioperative management of antithrombotic therapy in patients treated with coronary stents undergoing surgery remains poorly defined. Importantly, surgery represents a common reason for premature treatment discontinuation, which is associated with an increased risk in mortality and major adverse cardiac events. However, maintaining antithrombotic therapy to minimize the incidence of perioperative ischemic complications may increase the risk of bleeding complications. Although guidelines provide some recommendations with respect to the perioperative management of antithrombotic therapy, these have been largely developed according to the thrombotic risk of the patient and a definition of the hemorrhagic risk specific to each surgical procedure, key to defining the trade-off between ischemia and bleeding, is not provided. These observations underscore the need for a multidisciplinary collaboration among cardiologists, anesthesiologists, hematologists and surgeons to reach this goal. The present document is an update on practical recommendations for standardizing management of antithrombotic therapy management in patients treated with coronary stents (Surgery After Stenting 2) in various types of surgery according to the predicted individual risk of thrombotic complications against the anticipated risk of surgical bleeding complications. Cardiologists defined the thrombotic risk using a "combined ischemic risk" approach, while surgeons classified surgeries according to their inherent hemorrhagic risk. Finally, a multidisciplinary agreement on the most appropriate antithrombotic treatment regimen in the perioperative phase was reached for each surgical procedure. (C) 2018 by the American College of Cardiology Foundation.

Published
2017

34. Indications and practical approach to non-invasive ventilation in acute heart failure

Author

Masip, J. Peacock, W.F. Price, S. Cullen, L. Martin-Sanchez, F.J. Seferovic, P. Maisel, A.S. Miro, O. Filippatos, G. Vrints, C. Christ, M. Cowie, M. Platz, E. McMurray, J. Disomma, S. Zeymer, U. Bueno, H. Gale, C.P. Lettino, M. Tavares, M. Ruschitzka, F. Mebazaa, A. Harjola, V.-P. Mueller, C.

Abstract

In acute heart failure (AHF) syndromes significant respiratory failure (RF) is essentially seen in patients with acute cardiogenic pulmonary oedema (ACPE) or cardiogenic shock (CS). Non-invasive ventilation (NIV), the application of positive intrathoracic pressure through an interface, has shown to be useful in the treatment of moderate to severe RF in several scenarios. There are two main modalities of NIV: continuous positive airway pressure (CPAP) and pressure support ventilation (NIPSV) with positive end expiratory pressure. Appropriate equipment and experience is needed for NIPSV, whereas CPAP may be administered without a ventilator, not requiring special training. Both modalities have shown to be effective in ACPE, by a reduction of respiratory distress and the endotracheal intubation rate compared to conventional oxygen therapy, but the impact on mortality is less conclusive. Non-invasive ventilation is also indicated in patients with AHF associated to pulmonary disease and may be considered, after haemodynamic stabilization, in some patients with CS. There are no differences in the outcomes in the studies comparing both techniques, but CPAP is a simpler technique that may be preferred in low-equipped areas like the pre-hospital setting, while NIPSV may be preferable in patients with significant hypercapnia. The new modality â €high-flow nasal cannula' seems promising in cases of AHF with less severe RF. The correct selection of patients and interfaces, early application of the technique, the achievement of a good synchrony between patients and the ventilator avoiding excessive leakage, close monitoring, proactive management, and in some cases mild sedation, may warrant the success of the technique. © The Author 2017.

Published
2018

35. 2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS

Author

Valgimigli, M, Bueno, H, Byrne, RA, Collet, JP, Costa, F, Jeppsson, A, Juni, P, Kastrati, A, Kolh, P, Mauri, L, Montalescot, G, Neumann, FJ, Petricevic, M, Roffi, M, Steg, PG, Windecker, S, Zamorano, JL, Levine, GN, Badimon, L, Vranckx, P, Agewall, S, Andreotti, F, Antman, E, Barbato, E, Bassand, JP, Bugiardini, R, Cikirikcioglu, M, Cuisset, T, De Bonis, M, Delgado, V, Fitzsimons, D, Oliver, G, Galie, N, Gilard, M, Hamm, CW, Ibanez, B, Iung, B, James, S, Knuuti, J, Landmesser, U, Leclercq, C, Lettino, M, Lip, G, Piepoli, MF, Pierard, L, Schwerzmann, M, Sechtem, U, Simpson, IA, Uva, MS, Stabile, E, Storey, RF, Tendera, M, Van De Werf, F, Verheugt, F, Aboyans, V, Task Force Dual Antiplatelet Ther, and European Asso Cardio-Thoracic Surg

Subjects
Ticagrelor, Stable angina, Aspirin, Stent thrombosis, Revascularization, Bleeding, Coronary artery bypass grafting, Guidelines, Acute coronary syndromes, Recommendation, Coronary artery disease, Clopidogrel, Percutaneous coronary intervention, Myocardial infarction, Non-cardiac surgery, Dual antiplatelet therapy, Stents, Stable coronary artery disease, Oral anticoagulant, DAPT score, Triple therapy, Prasugrel, Drug-eluting stents, Risk stratification, PRECISE-DAPT score
Published
2018

36. 2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS

Author

Valgimigli, M., Bueno, H., Byrne, R. A., Collet, J. -P., Costa, F., Jeppsson, A., Kastrati, A., Kolh, P., Mauri, L., Montalescot, G., Neumann, F. -J., Petricevic, M., Roffi, M., Steg, P. G., Zamorano, J. L., Levine, G. N., Badimon, L., Vranckx, P., Agewall, S., Andreotti, Felicita, Antman, E., Barbato, E., Bassand, J. -P., Bugiardini, R., Cikirikcioglu, M., Cuisset, T., De Bonis, M., Delgado, V., Fitzsimons, D., Galie, N., Gilard, M., Hamm, C. W., Ibanez, B., James, S., Knuuti, J., Landmesser, U., Leclercq, C., Lettino, M., Lip, G., Piepoli, M. F., Pierard, L., Schwerzmann, M., Sechtem, U., Simpson, I. A., Uva, M. S., Stabile, E., Storey, R. F., Tendera, M., Van De Werf, F., Verheugt, F., Aboyans, V., Windecker, S., Coca, A., Coman, I. M., Dean, V., Gaemperli, O., Hindricks, G., Iung, B., Juni, P., Katus, H. A., Lancellotti, P., Mcdonagh, T., Ponikowski, P., Richter, D. J., Shlyakhto, E., Roithinger, F. X., Aliyev, F., Stelmashok, V., Desmet, W., Postadzhiyan, A., Georghiou, G. P., Motovska, Z., Grove, E. L., Marandi, T., Kiviniemi, T., Kedev, S., Massberg, S., Alexopoulos, D., Kiss, R. G., Gudmundsdottir, I. J., Mcfadden, E. P., Lev, E., De Luca, L., Sugraliyev, A., Haliti, E., Mirrakhimov, E., Latkovskis, G., Petrauskiene, B., Huijnen, S., Magri, C. J., Cherradi, R., Ten Berg, J. M., Eritsland, J., Budaj, A., Aguiar, C. T., Duplyakov, D., Zavatta, M., Antonijevic, N. M., Fras, Z., Montoliu, A. T., Varenhorst, C., Tsakiris, D., Addad, F., Aydogdu, S., Parkhomenko, A., Kinnaird, T., Andreotti F. (ORCID:0000-0002-1456-6430), Valgimigli, M., Bueno, H., Byrne, R. A., Collet, J. -P., Costa, F., Jeppsson, A., Kastrati, A., Kolh, P., Mauri, L., Montalescot, G., Neumann, F. -J., Petricevic, M., Roffi, M., Steg, P. G., Zamorano, J. L., Levine, G. N., Badimon, L., Vranckx, P., Agewall, S., Andreotti, Felicita, Antman, E., Barbato, E., Bassand, J. -P., Bugiardini, R., Cikirikcioglu, M., Cuisset, T., De Bonis, M., Delgado, V., Fitzsimons, D., Galie, N., Gilard, M., Hamm, C. W., Ibanez, B., James, S., Knuuti, J., Landmesser, U., Leclercq, C., Lettino, M., Lip, G., Piepoli, M. F., Pierard, L., Schwerzmann, M., Sechtem, U., Simpson, I. A., Uva, M. S., Stabile, E., Storey, R. F., Tendera, M., Van De Werf, F., Verheugt, F., Aboyans, V., Windecker, S., Coca, A., Coman, I. M., Dean, V., Gaemperli, O., Hindricks, G., Iung, B., Juni, P., Katus, H. A., Lancellotti, P., Mcdonagh, T., Ponikowski, P., Richter, D. J., Shlyakhto, E., Roithinger, F. X., Aliyev, F., Stelmashok, V., Desmet, W., Postadzhiyan, A., Georghiou, G. P., Motovska, Z., Grove, E. L., Marandi, T., Kiviniemi, T., Kedev, S., Massberg, S., Alexopoulos, D., Kiss, R. G., Gudmundsdottir, I. J., Mcfadden, E. P., Lev, E., De Luca, L., Sugraliyev, A., Haliti, E., Mirrakhimov, E., Latkovskis, G., Petrauskiene, B., Huijnen, S., Magri, C. J., Cherradi, R., Ten Berg, J. M., Eritsland, J., Budaj, A., Aguiar, C. T., Duplyakov, D., Zavatta, M., Antonijevic, N. M., Fras, Z., Montoliu, A. T., Varenhorst, C., Tsakiris, D., Addad, F., Aydogdu, S., Parkhomenko, A., Kinnaird, T., and Andreotti F. (ORCID:0000-0002-1456-6430)

Abstract

N/A

Published
2018

38. Consensus on: Screening and therapy of coronary heart disease in diabetic patients

Author

Rivellese AA1, Piatti PM, Italian Intersociety Consensus G.r.o.u.p. Collaborators Piatti PM, Avogaro A, Anfossi G, Ardigo D, de Kreutzenberg SV, Inchiostro S, Rivellese AA, Trovati M, Zambon S, Zavaroni I, Arcangeli A, Lettino M, Mafrici A, Uguccioni M, Bianchi A, Cavallaro V, Monducci I, Cadeddu C, De Luca G, Manzato E., GENTILE, Sandro, Rivellese, ANGELA ALBAROSA, P. M., Piatti, Rivellese, Aa1, Piatti, Pm, Collaborators Piatti PM, Italian Intersociety Consensus G. r. o. u. p., Avogaro, A, Anfossi, G, Ardigo, D, de Kreutzenberg, Sv, Inchiostro, S, Rivellese, Aa, Trovati, M, Zambon, S, Zavaroni, I, Arcangeli, A, Gentile, Sandro, Lettino, M, Mafrici, A, Uguccioni, M, Bianchi, A, Cavallaro, V, Monducci, I, Cadeddu, C, De Luca, G, and Manzato, E.

Subjects
medicine.medical_specialty, Diabetic Cardiomyopathies, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Cardiovascular risk factors, MEDLINE, Coronary heart disease, Diabetes, Cardiovascular risk factors, Medicine (miscellaneous), Coronary Disease, Revascularization, Electrocardiography, Risk Factors, Diabetes mellitus, Myocardial Revascularization, medicine, Humans, Hypoglycemic Agents, Intensive care medicine, Antihypertensive Agents, Hypolipidemic Agents, Nutrition and Dietetics, Framingham Risk Score, medicine.diagnostic_test, business.industry, Diabetes, Evidence-based medicine, medicine.disease, Coronary heart disease, Italy, Echocardiography, Physical therapy, Cardiology and Cardiovascular Medicine, business, Platelet Aggregation Inhibitors
Abstract

The screening and best treatment for coronary heart disease in diabetic patients is still a matter of debate. For this reason the main Italian scientific societies dealing with diabetes and cardiovascular diseases have tried to finalize a document providing shared recommendations based on the available evidence on : 1) how and who to screen for coronary heart disease, 2) methodologies for the characterization of existing coronary heart disease 3) evaluation of the optimal treatment of cardiovascular risk factors and 4) appropriate revascularization procedures. For each of these points, the levels of evidence and strength of recommendations used in the Italian Standard of Care were adopted.

Published
2011

39. Diabetic patients with acute coronary syndromes in contemporary European registries: characteristics and outcomes

Author

Lettino, M., Andell, P., Zeymer, U., Widimsky, P., Danchin, N., Bardaji, A., Barrabes, J.A., Cequier, A., Claeys, M.J., Luca, L. de, Dorler, J., Erlinge, D., Erne, P., Goldstein, P., Koul, S.M., Lemesle, G., Luscher, T.F., Matter, C.M., Montalescot, G., Radovanovic, D., Sendon, J.L., Tousek, P., Weidinger, F., Weston, C.F.M., Zaman, A., Li, J., Jukema, J.W., PIRAEUS Grp, and PIRAEUS Grp

Subjects
Male, Ticagrelor, Prasugrel, Time Factors, Type 2 diabetes, 030204 cardiovascular system & hematology, ST-segment elevation, 0302 clinical medicine, Diabetes mellitus, Recurrence, Risk Factors, Pharmacology (medical), 030212 general & internal medicine, Myocardial infarction, Hospital Mortality, Registries, Coronary Artery Bypass, Practice Patterns, Physicians', 610 Medicine & health, Non-ST Elevated Myocardial Infarction, Observational, education.field_of_study, Middle Aged, Clopidogrel, Prognosis, Europe, P2Y12 receptor inhibitors, Female, Cardiology and Cardiovascular Medicine, medicine.drug, medicine.medical_specialty, Population, Hemorrhage, Acute coronary syndromes, Risk Assessment, 03 medical and health sciences, Percutaneous Coronary Intervention, Internal medicine, medicine, Humans, Angina, Unstable, Acute Coronary Syndrome, Antiplatelets, education, Aged, business.industry, Unstable angina, medicine.disease, Non-ST-segment elevation, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Relative risk, ST Elevation Myocardial Infarction, Human medicine, business, Platelet Aggregation Inhibitors
Abstract

Aims Among patients with acute coronary syndromes (ACS), those with diabetes mellitus (DM) are at particularly high risk of recurrent cardiovascular events and premature death. We aimed to provide a descriptive overview of unadjusted analyses of patient characteristics, ACS management, and outcomes up to 1 year after hospital admission for an ACS/index-ACS event, in patients with DM in contemporary registries in Europe. Methods and results A total of 10 registries provided data in a systematic manner on ACS patients with DM (total n =28 899), and without DM (total n= 97 505). In the DM population, the proportion of patients with ST-Segment Elevation Myocardial Infarction (STEMI) ranged from 22.1% to 64.6% (other patients had non-ST-Segment Elevation Myocardial Infarction (NSTEMI-ACS) or unstable angina). All-cause mortality in the registries ranged from 1.4% to 9.4% in-hospital; 2.8% to 7.9% at 30 days post-discharge; 5.1% to 10.7% at 180 days post-discharge; and 3.3% to 10.5% at 1 year post-discharge. Major bleeding events were reported in up to 3.8% of patients while in hospital (8 registries); up to 1.3% at 30 days (data from two registries only), and 2.0% at 1 year (one registry only). Registries differed substantially in terms of study setting, site, patient selection, definition and schedule of endpoints, and use of various P2Y12 inhibitors. In most, but not all, registries, event rates in DM patients were higher than in patients without DM. Pooled risk ratios comparing cohorts with DM vs. no DM were in-hospital significantly higher in DM for all-cause death (1.66; 95% CI 1.42-1.94), for cardiovascular death (2.33; 1.78 - 3.03), and for major bleeding (1.35; 1.21-1.52). Conclusion These registry data from real-life clinical practice confirm a high risk for recurrent events among DM patients with ACS, with great variation across the different registries.

Published
2017

41. P2686Role of optimal medical therapy on perioperative outcome in patients with heart failure and coronary artery disease undergoing surgery: insights from the SAS registry

Author

Rossini, R, primary, Iorio, A, additional, Musumeci, G, additional, Savonitto, S, additional, Trabattoni, D, additional, Lettino, M, additional, Molfese, M, additional, Lettieri, C, additional, Ferlini, M, additional, Oltrona Visconti, L, additional, Piccaluga, E, additional, Masiero, G, additional, Caporale, R, additional, Calchera, I, additional, and Tarantini, G, additional

Published
2018
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42. P2644The Surgery after Stent (SAS) Registry: a gender-based analysis on clinical outcomes in women undergoing cardiac and non-cardiac surgery

Author

Collaku, E, primary, Trabattoni, D, additional, Savonitto, S, additional, Musumeci, G, additional, Calchera, I, additional, Lettino, M, additional, Molfese, M, additional, Piatti, L, additional, Tarantini, G, additional, Piccaluga, E, additional, Oltrona Visconti, L, additional, Ferlini, M, additional, Caporale, R, additional, Masiero, G, additional, and Rossini, R, additional

Published
2018
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43. Perioperative management of antiplatelet therapy in patients with coronary stents undergoing cardiac and non-cardiac surgery: a consensus document from Italian cardiological, surgical and anaesthesiological societies

Author

Rossini, R, Musumeci, G, Visconti, L, Bramucci, E, Castiglioni, B, De Servi, S, Lettieri, C, Lettino, M, Lorini, F, Antonelli, M, Bovenzi, F, Cremonesi, A, Angiolillo, D, Guagliumi, G, Rossini R, Musumeci G, Visconti LO, Bramucci E, Castiglioni B, De Servi S, Lettieri C, Lettino M, Lorini F, Antonelli M, Bovenzi F, Cremonesi A, Angiolillo DJ, Guagliumi G, Rossini, R, Musumeci, G, Visconti, L, Bramucci, E, Castiglioni, B, De Servi, S, Lettieri, C, Lettino, M, Lorini, F, Antonelli, M, Bovenzi, F, Cremonesi, A, Angiolillo, D, Guagliumi, G, Rossini R, Musumeci G, Visconti LO, Bramucci E, Castiglioni B, De Servi S, Lettieri C, Lettino M, Lorini F, Antonelli M, Bovenzi F, Cremonesi A, Angiolillo DJ, and Guagliumi G

Abstract

Optimal perioperative antiplatelet therapy in patients with coronary stents undergoing surgery still remains poorly defined and a matter of debate among cardiologists, surgeons and anaesthesiologists. Surgery represents one of the most common reasons for premature antiplatelet therapy discontinuation, which is associated with a significant increase in mortality and major adverse cardiac events, in particular stent thrombosis. Clinical practice guidelines provide little support with regard to managing antiplatelet therapy in the perioperative phase in the case of patients with non-deferrable surgical interventions and/or high haemorrhagic risk. Moreover, a standard definition of ischaemic and haemorrhagic risk has never been determined. Finally, recommendations shared by cardiologists, surgeons and anaesthesiologists are lacking. The present consensus document provides practical recommendations on the perioperative management of antiplatelet therapy in patients with coronary stents undergoing surgery. Cardiologists, surgeons and anaesthesiologists have contributed equally to its creation. On the basis of clinical and angiographic data, the individual thrombotic risk has been defined. All surgical interventions have been classified according to their inherent haemorrhagic risk. A consensus on the optimal antiplatelet regimen in the perioperative phase has been reached on the basis of the ischaemic and haemorrhagic risk. Aspirin should be continued perioperatively in the majority of surgical operations, whereas dual antiplatelet therapy should not be withdrawn for surgery in the case of low bleeding risk. In selected patients at high risk for both bleeding and ischaemic events, when oral antiplatelet therapy withdrawal is required, perioperative treatment with short-acting intravenous glycoprotein IIb/IIIa inhibitors (tirofiban or eptifibatide) should be taken into consideration.

Published
2014

44. Editor's Choice-The organization of chest pain units: Position statement of the Acute Cardiovascular Care Association

Author

Claeys, M.J. (Marc J.), Ahrens, I. (Ingo), Sinnaeve, P.R. (Peter), Diletti, R. (Roberto), Rossini, R. (Roberta), Goldstein, P. (Patrick), Czerwińska, K. (Kasia), Bueno, H. (Hector), Lettino, M., Munzel, T. (Thomas), Zeymer, U. (Uwe), Claeys, M.J. (Marc J.), Ahrens, I. (Ingo), Sinnaeve, P.R. (Peter), Diletti, R. (Roberto), Rossini, R. (Roberta), Goldstein, P. (Patrick), Czerwińska, K. (Kasia), Bueno, H. (Hector), Lettino, M., Munzel, T. (Thomas), and Zeymer, U. (Uwe)

Abstract

Chest pain units are defined as organizational short stay units with specific management protocols designed to facilitate and optimize the diagnosis of patients presenting with chest pain in the emergency department. The present document is intended to standardize and facilitate the installation of chest pain units nearby to the emergency department or as an integral part of the emergency department. Recommendations on organizational structure, physical and technical requirements and on disease management are presented. More standardized installation and implementation of chest pain units will enhance the quality of chest pain units and improve the quality of care of our chest pain patients.

Published
2017
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46. [ANMCO/SICI-GISE document on antiplatelet therapy in patients with acute coronary syndrome]

Author

De Luca, Leonardo, Bolognese, Leonardo, Valgimigli, Marco, Ceravolo, Roberto, Danzi, Gian Battista, Piccaluga, Emanuela, Rakar, Serena, Cremonesi, Alberto, Bovenzi, Francesco Maria, Abbate, R, Andreotti, F, Bolognese, L, Biondi Zoccai, G, Bovenzi, FM, Capodanno, D, Caporale, R, Capranzano, P, Carrabba, N, Casella, G, Cavallini, C, Ceravolo, R, Colombo, P, Conte, MR, Cordone, S, Cremonesi, A, Danzi, GB, Del Pinto, M, De Luca, G, De Luca, L, De Servi, S, Di Lorenzo, E, Di Pasquale, G, Farina, R, Fiscella, A, Formigli, D, Galli, S, Giudice, P, Gonzi, G, Greco, C, Grieco, NB, La Vecchia, L, Lazzari, M, Lettieri, C, Lettino, M, Limbruno, U, Lupi, A, Macchi, A, Marini, M, Marzilli, M, Montinaro, A, Musumeci, G, Navazio, A, Olivari, Z, Oltrona Visconti, L, Oreglia, JA, Ottani, F, Parodi, G, Pasquetto, G, Patti, G, Perkan, A, Perna, GP, Piccaluga, E, Piscione, F, Prati, F, Rakar, S, Ravasio, R, Ronco, F, Rossini, R, Rubboli, A, Saia, F, Sardella, G, Satullo, G, Savonitto, S, Sbarzaglia, P, Scorcu, G, Signore, N, Tarantini, G, Terrosu, P, Testa, L, Tubaro, M, Valente, S, Valgimigli, M, Varbella, F, Vatrano, M., ESPOSITO, GIOVANNI, De Luca, Leonardo, Bolognese, Leonardo, Valgimigli, Marco, Ceravolo, Roberto, Danzi, Gian Battista, Piccaluga, Emanuela, Rakar, Serena, Cremonesi, Alberto, Bovenzi, Francesco Maria, Abbate, R, Andreotti, F, Bolognese, L, Biondi Zoccai, G, Bovenzi, Fm, Capodanno, D, Caporale, R, Capranzano, P, Carrabba, N, Casella, G, Cavallini, C, Ceravolo, R, Colombo, P, Conte, Mr, Cordone, S, Cremonesi, A, Danzi, Gb, Del Pinto, M, De Luca, G, De Luca, L, De Servi, S, Di Lorenzo, E, Di Pasquale, G, Esposito, Giovanni, Farina, R, Fiscella, A, Formigli, D, Galli, S, Giudice, P, Gonzi, G, Greco, C, Grieco, Nb, La Vecchia, L, Lazzari, M, Lettieri, C, Lettino, M, Limbruno, U, Lupi, A, Macchi, A, Marini, M, Marzilli, M, Montinaro, A, Musumeci, G, Navazio, A, Olivari, Z, Oltrona Visconti, L, Oreglia, Ja, Ottani, F, Parodi, G, Pasquetto, G, Patti, G, Perkan, A, Perna, Gp, Piccaluga, E, Piscione, F, Prati, F, Rakar, S, Ravasio, R, Ronco, F, Rossini, R, Rubboli, A, Saia, F, Sardella, G, Satullo, G, Savonitto, S, Sbarzaglia, P, Scorcu, G, Signore, N, Tarantini, G, Terrosu, P, Testa, L, Tubaro, M, Valente, S, Valgimigli, M, Varbella, F, and Vatrano, M.

Subjects
Acute Coronary Syndrome, Platelet Aggregation Inhibitors, Human
Abstract

Antiplatelet therapy is the cornerstone of the pharmacologic management of patients with acute coronary syndrome (ACS). Over the last years, several studies have evaluated old and new oral or intravenous antiplatelet agents in ACS patients. In particular, research was focused on assessing superiority of two novel platelet ADP P2Y12 receptor antagonists (i.e., prasugrel and ticagrelor) over clopidogrel. Several large randomized controlled trials have been undertaken in this setting and a wide variety of prespecified and post-hoc analyses are available that evaluated the potential benefits of novel antiplatelet therapies in different subsets of patients with ACS. The aim of this document is to review recent data on the use of current antiplatelet agents for in-hospital treatment of ACS patients. For each drug or class of drugs, strong evidence and/or areas of uncertainty that warrant further research are highlighted by examining 10 subgroups of patients with ACS.

Published
2013

47. Pre-hospital treatment of STEMI patients. A scientific statement of the working group acute cardiac care of the European society of cardiology [Tratamiento prehospitalario de los pacientes con IAMCEST. Una declaración científica del Working Group Acute Cardiac Care de la European Society of Cardiology]

Author

Tubaro, M. Danchin, N. Goldstein, P. Filippatos, G. Hasin, Y. Heras, M. Jansky, P. Norekval, T.M. Swahn, E. Thygesen, K. Vrints, C. Zahger, D. Arntz, H.R. Bellou, A. De La Coussaye, J.E. De Luca, L. Huber, K. Lambert, Y. Lettino, M. Lindahl, B. McLean, S. Nibbe, L. Peacock, W.F. Price, S. Quinn, T. Spaulding, C. Tatu-Chitoiu, G. Van De Werf, F.

Subjects
cardiovascular diseases
Abstract

In ST-elevation myocardial infarction (STEMI) the pre-hospital phase is the most critical, as the administration of the most appropriate treatment in a timely manner is instrumental for mortality reduction. STEMI systems of care based on networks of medical institutions connected by an efficient emergency medical service are pivotal. The first steps are devoted to minimize the patient's delay in seeking care, rapidly dispatch a properly staffed and equipped ambulance to make the diagnosis on scene, deliver initial drug therapy and transport the patient to the most appropriate (not necessarily the closest) cardiac facility. Primary PCI is the treatment of choice, but thrombolysis followed by coronary angiography and possibly PCI is a valid alternative, according to patient's baseline risk, time from symptoms onset and primary PCI-related delay. Paramedics and nurses have an important role in pre-hospital STEMI care and their empowerment is essential to increase the eff ectiveness of the system. Strong cooperation between cardiologists and emergency medicine doctors is mandatory for optimal pre-hospital STEMI care. Scientific societies have an important role in guideline implementation as well as in developing quality indicators and performance measures; health care professionals must overcome existing barriers to optimal care together with political and administrative decision makers. © 2011 Sociedad Española de Cardiología. Published by Elsevier España, S.L. All rights reserved.

Published
2012

48. Coronary stenting and surgery: Perioperative management of antiplatelet therapy in patients undergoing surgery after coronary stent implantation [Stent coronarico e chirurgia: La gestione perioperatoria della terapia antiaggregante nel paziente portatore di stent coronarico candidato a intervento chirurgico]

Author

Rossini, R., Bramucci, E., Castiglioni, B., DE SERVI, S., Lettieri, C., Lettino, M., Masumeci, G., Visconti, L., Piccaluga, E., Savonitto, S., Trabattoni, D., Buffoli, F., Angiolillo, D., Bovenzi, F., Cremonesi, A., Scherillo, M., Guagliumi, G., Valdatta, Luigi, Boni, Luigi, Dionigi, G., Guffanti, E., Gerometta, P., Parolari, A., Biglioli, F., Beltramini, G., Devalle, L., Droghetti, A., Bozzani, A., Ravelli, P., Crescini, C., Staurenghi, G., Gaini, S., Scarone, P., Francetti, L., Corbella, S., Comel, A., Gadda, F., Salvi, L., Castelli, A., Menozzi, E., and D'Angelo, Fabio

Subjects
Surgical Procedures, Aspirin, Clopidogrel, Coronary heart disease, Stent, Surgery, Coronary Disease, Humans, Platelet Aggregation Inhibitors, Postoperative Hemorrhage, Risk Assessment, Risk Factors, Stents, Surgical Procedures, Operative, Cardiology and Cardiovascular Medicine, Operative
Published
2012

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