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284 results on '"Lerch, M.M."'

1. Type 1 Autoimmune Pancreatitis in Europe: Clinical Profile and Response to Treatment

Author

Drewes, A. Mohr, Haas, S.L., Hoyer, B.F., Hampe, J., Hinrichs, C. Noreen, Lerch, M.M., Aghdassi, A.A., Grote, T., Heuser, D.J., Ignatavicius, P., Malecka-Panas, E., Domínguez-Muñoz, J.E., López-Serrano, A., Auriemma, F., Oracz, G., Duman, D., Gubergrits, N., Overbeek, Kasper A., Poulsen, Jakob L., Lanzillotta, Marco, Vinge-Holmquist, Olof, Macinga, Peter, Demirci, A. Fatih, Sindhunata, Daniko P., Backhus, Johanna, Algül, Hana, Buijs, Jorie, Levy, Philippe, Kiriukova, Mariia, Goni, Elisabetta, Hollenbach, Marcus, Miksch, Rainer C., Kunovsky, Lumir, Vujasinovic, Miroslav, Nikolic, Sara, Dickerson, Luke, Hirth, Michael, Neurath, Markus F., Zumblick, Malte, Vila, Josephine, Jalal, Mustafa, Beyer, Georg, Frost, Fabian, Carrara, Silvia, Kala, Zdenek, Jabandziev, Petr, Sisman, Gurhan, Akyuz, Filiz, Capurso, Gabriele, Falconi, Massimo, Arlt, Alexander, Vleggaar, Frank P., Barresi, Luca, Greenhalf, Bill, Czakó, László, Hegyi, Peter, Hopper, Andrew, Nayar, Manu K., Gress, Thomas M., Vitali, Francesco, Schneider, Alexander, Halloran, Chris M., Trna, Jan, Okhlobystin, Alexey V., Dagna, Lorenzo, Cahen, Djuna L., Bordin, Dmitry, Rebours, Vinciane, Mayerle, Julia, Kahraman, Alisan, Rasch, Sebastian, Culver, Emma, Kleger, Alexander, Martínez-Moneo, Emma, Røkke, Ola, Hucl, Tomas, Olesen, Søren S., Bruno, Marco J., Della-Torre, Emanuel, Beuers, Ulrich, Löhr, J.-Matthias, and Rosendahl, Jonas

Published
2024
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2. Type 1 Autoimmune Pancreatitis in Europe: Clinical Profile and Response to Treatment

Author

Overbeek, Kasper A., primary, Poulsen, Jakob L., additional, Lanzillotta, Marco, additional, Vinge-Holmquist, Olof, additional, Macinga, Peter, additional, Demirci, A. Fatih, additional, Sindhunata, Daniko P., additional, Backhus, Johanna, additional, Algül, Hana, additional, Buijs, Jorie, additional, Levy, Philippe, additional, Kiriukova, Mariia, additional, Goni, Elisabetta, additional, Hollenbach, Marcus, additional, Miksch, Rainer C., additional, Kunovsky, Lumir, additional, Vujasinovic, Miroslav, additional, Nikolic, Sara, additional, Dickerson, Luke, additional, Hirth, Michael, additional, Neurath, Markus F., additional, Zumblick, Malte, additional, Vila, Josephine, additional, Jalal, Mustafa, additional, Beyer, Georg, additional, Frost, Fabian, additional, Carrara, Silvia, additional, Kala, Zdenek, additional, Jabandziev, Petr, additional, Sisman, Gurhan, additional, Akyuz, Filiz, additional, Capurso, Gabriele, additional, Falconi, Massimo, additional, Arlt, Alexander, additional, Vleggaar, Frank P., additional, Barresi, Luca, additional, Greenhalf, Bill, additional, Czakó, László, additional, Hegyi, Peter, additional, Hopper, Andrew, additional, Nayar, Manu K., additional, Gress, Thomas M., additional, Vitali, Francesco, additional, Schneider, Alexander, additional, Halloran, Chris M., additional, Trna, Jan, additional, Okhlobystin, Alexey V., additional, Dagna, Lorenzo, additional, Cahen, Djuna L., additional, Bordin, Dmitry, additional, Rebours, Vinciane, additional, Mayerle, Julia, additional, Kahraman, Alisan, additional, Rasch, Sebastian, additional, Culver, Emma, additional, Kleger, Alexander, additional, Martínez-Moneo, Emma, additional, Røkke, Ola, additional, Hucl, Tomas, additional, Olesen, Søren S., additional, Bruno, Marco J., additional, Della-Torre, Emanuel, additional, Beuers, Ulrich, additional, Löhr, J.-Matthias, additional, Rosendahl, Jonas, additional, Drewes, A. Mohr, additional, Haas, S.L., additional, Hoyer, B.F., additional, Hampe, J., additional, Hinrichs, C. Noreen, additional, Lerch, M.M., additional, Aghdassi, A.A., additional, Grote, T., additional, Heuser, D.J., additional, Ignatavicius, P., additional, Malecka-Panas, E., additional, Domínguez-Muñoz, J.E., additional, López-Serrano, A., additional, Auriemma, F., additional, Oracz, G., additional, Duman, D., additional, and Gubergrits, N., additional

Published
2024
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3. Pancreatic cyst surveillance imposes low psychological burden

Author

Bruno, M.J., Cahen, D.L., van Riet, P.A., Overbeek, K.A., Levink, I.J.M., Koopmann, B., Besselink, M.G.H., del Chiaro, M., Lerch, M.M., Wallace, M.B., van Ballegooijen, M., Biermann, K., Bleiker, E.M.A., Bollen, T.H.L., Fockens, P., de Kok, I.M.C.M., Looijenga, L.H.J., Peppelenbosch, M.P., Verhagen-Oldenampsen, J.H.E., Arcidiacono, P.G., Capurso, G., Bergmann, J., van Berkel, A., Beyer, G., Bijlsma, R., Braat, H., Carrara, S., Czakó, L., van Erp-van der Steen, H., Ganesh, S., van Geenen, E., Gonda, T., Hoge, C., Honkoop, P., van Hooft, J.E., Jansen, J., Larghi, A., van Leeuwenburgh, I., Laukkarinen, J., Lelyveld, N., Lerch, M., di Marco, M.C., Ricci, C., Casadei, R., Rau, E.P., Perk, L., Polkowski, M., Pukitits, A., Quispel, R., Radenkovic, D., Seicean, A., Schwartz, T., Schoon, E.J., van Soest, E., Tan, A., Venneman, N.G., Vos, P., Voorburg, A., van der Waaij, L.A., Wijkerslooth, L.R.H., Zerboni, G., della Fave, G., Zonderhuis, B., Overbeek, Kasper A., Kamps, Anne, van Riet, Priscilla A., Di Marco, Mariacristina, Zerboni, Giulia, van Hooft, Jeanin E., Carrara, Silvia, Ricci, Claudio, Gonda, Tamas A., Schoon, Erik, Polkowski, Marcin, Beyer, Georg, Honkoop, Pieter, van der Waaij, Laurens A., Casadei, Riccardo, Capurso, Gabriele, Erler, Nicole S., Bruno, Marco J., Bleiker, Eveline M.A., and Cahen, Djuna L.

Published
2019
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8. Efficacy of gemcitabine plus erlotinib in rash-positive patients with metastatic pancreatic cancer selected according to eligibility for FOLFIRINOX: A prospective phase II study of the ‘Arbeitsgemeinschaft Internistische Onkologie’

Author

Haas, M., Siveke, J.T., Schenk, M., Lerch, M.M., Caca, K., Freiberg-Richter, J., Fischer von Weikersthal, L., Kullmann, F., Reinacher-Schick, A., Fuchs, M., Kanzler, S., Kunzmann, V., Ettrich, T.J., Kruger, S., Westphalen, C.B., Held, S., Heinemann, V., and Boeck, S.

Published
2018
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10. Impaired Muscle Function Is Rarely Seen In Malnourished Patients With Chronic Pancreatitis Despite Prominently Low Skeletal Muscle Mass

Author

Wiese, M.L., primary, Gärtner, S., additional, von Essen, N., additional, Doller, J., additional, Frost, F., additional, Tran, Q.T., additional, Weiss, F.U., additional, Meyer, F., additional, Valentini, L., additional, Garbe, L.-A., additional, Metges, C.C., additional, Bannert, K., additional, Sautter, L.F., additional, Ehlers, L., additional, Jaster, R., additional, Lamprecht, G., additional, Steveling, A., additional, Lerch, M.M., additional, and Aghdassi, A.A., additional

Published
2023
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11. CEA response is associated with tumor response and survival in patients with KRAS exon 2 wild-type and extended RAS wild-type metastatic colorectal cancer receiving first-line FOLFIRI plus cetuximab or bevacizumab (FIRE-3 trial)

Author

Michl, M., Stintzing, S., Fischer von Weikersthal, L., Decker, T., Kiani, A., Vehling-Kaiser, U., Al-Batran, S.-E., Heintges, T., Lerchenmueller, C., Kahl, C., Seipelt, G., Kullmann, F., Stauch, M., Scheithauer, W., Hielscher, J., Scholz, M., Mueller, S., Lerch, M.M., Modest, D.P., Kirchner, T., Jung, A., and Heinemann, V.

Published
2016
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15. Independent validation and assay standardization of improved metabolic biomarker signature to differentiate pancreatic ductal adenocarcinoma from chronic pancreatitis

Author

Mahajan, Ujjwal M., primary, Oehrle, B., additional, Sirtl, S., additional, Alnatsha, A., additional, Goni, E., additional, Regel, I., additional, Beyer, G., additional, Vornhülz, M., additional, Chromik, A., additional, Bahra, M., additional, Klein, F., additional, Uhl, W., additional, Fahlbusch, T., additional, Distler, M., additional, Weitz, J., additional, Grützmann, R., additional, Pilarsky, C., additional, Weiss, F. Ulrich, additional, Adam, G., additional, Kalthoff, H., additional, Rad, R., additional, Christiansen, N., additional, Bethan, B., additional, Kamlage, B., additional, Lerch, M.M., additional, and Mayerle, J., additional

Published
2022
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17. Diskrepanz zwischen der Prävalenz von reduzierter Muskelmasse und Sarkopenie bei Menschen mit chronischer Pankreatitis

Author

Wiese, M.L., additional, Gärtner, S., additional, Doller, J., additional, Frost, F., additional, Tran, Q.T., additional, Weiß, F.U., additional, Meyer, F., additional, Valentini, L., additional, Garbe, L.-A., additional, Metges, C.C., additional, Bannert, K., additional, Jaster, R., additional, Lamprecht, G., additional, Lerch, M.M., additional, and Aghdassi, A.A., additional

Published
2022
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18. SARS-CoV-2 Pandemie assoziierte Veränderungen der Körperzusammensetzung und kardiovaskulärer Risikofaktoren von gesunden Kontrollpersonen des Verbundprojektes EnErGie

Author

Benzin, W., additional, Meyer, F., additional, Bannert, K., additional, Wiese, M., additional, Sautter, L.F., additional, Esau, S., additional, Metges, C.C., additional, Garbe, L.A., additional, Aghdassi, A.A., additional, Lerch, M.M., additional, Jaster, R., additional, Lamprecht, G., additional, and Valentini, L., additional

Published
2022
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19. Prädiktoren der Fatigue bei Patient*innen mit Leberzirrhose: Ergebnisse einer multizentrischen Querschnittsstudie

Author

Meyer, F., additional, Bannert, K., additional, Wiese, M., additional, Sautter, L.F., additional, Esau, S., additional, Müller, J., additional, Ehlers, L., additional, Metges, C.C., additional, Garbe, L.A., additional, Aghdassi, A.A., additional, Lerch, M.M., additional, Jaster, R., additional, Lamprecht, G., additional, and Valentini, L., additional

Published
2022
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20. Vergleich der Verzehrsgewohnheiten von Patienten mit chronischer Pankreatitis und Leberzirrhose mit und ohne Mangelernährung

Author

Bruns, N., additional, Wiese, M.L., additional, Meyer, F., additional, Bannert, K., additional, Sautter, L.F., additional, Doller, J., additional, Frost, F., additional, Tran, Q.T., additional, Weiß, F.U., additional, Garbe, L.-A., additional, Metges, C.C., additional, Valentini, L., additional, Jaster, R., additional, Lamprecht, G., additional, Gärtner, S., additional, Lerch, M.M., additional, and Aghdassi, A.A., additional

Published
2022
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21. Mangelernährung bei oral ernährten Kurzdarmsyndrom-Patienten geht mit verringerter Muskelmasse einher, beeinträchtigt jedoch nicht die Muskelfunktion

Author

Bannert, K., additional, Sautter, L.F., additional, Karbe, C., additional, Meyer, F., additional, Valentini, L., additional, Wiese, M.L., additional, Gärtner, S., additional, Aghdassi, A.A., additional, Lerch, M.M., additional, Ehlers, L., additional, Jaster, R., additional, and Lamprecht, G., additional

Published
2022
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25. Feasibility of a 3-month supportive ambulant nutrition therapy (SANT) in malnourished patients with liver cirrhosis and chronic pancreatitis

Author

Mueller, J., primary, Meyer, F., additional, Sautter, L.F., additional, Wiese, M., additional, Esau, S., additional, Bannert, K., additional, Ehlers, L., additional, Gaertner, S., additional, Aghdassi, A.A., additional, Lerch, M.M., additional, Jaster, R., additional, Lamprecht, G., additional, and Valentini, L., additional

Published
2021
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31. Large-scale association analyses identify host factors influencing human gut microbiome composition

Author

Kurilshikov, A., Medina-Gomez, C., Bacigalupe, R., Radjabzadeh, D., Wang, J, Demirkan, A., Roy, C.I. Le, Garay, J.A. Raygoza, Finnicum, C.T., Liu, X, Zhernakova, D.V., Bonder, M.J., Hansen, T.H., Frost, F., Rühlemann, M.C., Turpin, W., Moon, J.Y., Kim, H.N., Lüll, K., Barkan, E., Shah, S.A., Fornage, M., Szopinska-Tokov, J.W., Wallen, Z.D., Borisevich, D., Agreus, L., Andreasson, A., Bang, C., Bedrani, L., Bell, J.T., Bisgaard, H., Boehnke, M., Boomsma, D.I., Burk, R.D., Claringbould, A., Croitoru, K., Davies, G.E., Duijn, C.M. van, Duijts, L., Falony, G., Fu, J., Graaf, A. de, Hansen, T., Homuth, G., Hughes, D.A., Ijzerman, R.G., Jackson, M.A., Jaddoe, V.W.V., Joossens, M., Jørgensen, T., Keszthelyi, D., Knight, R., Laakso, M., Laudes, M., Launer, L.J., Lieb, W., Lusis, A.J., Masclee, A.A.M., Moll, H.A., Mujagic, Z., Qibin, Q., Rothschild, D., Shin, H., Sørensen, S.J., Steves, C.J., Thorsen, J., Timpson, N.J., Tito, R.Y., Vieira-Silva, S., Völker, U., Völzke, H., Võsa, U., Wade, K.H., Walter, S., Watanabe, K., Weiss, S., Weiss, F.U., Weissbrod, O., Westra, H.J., Willemsen, G., Payami, H., Jonkers, D., Arias Vasquez, A., Geus, E.J.C. de, Meyer, K.A., Stokholm, J., Segal, E., Org, E., Wijmenga, C., Kim, H.L., Kaplan, R.C., Spector, T.D., Uitterlinden, A.G., Rivadeneira, F., Franke, A., Lerch, M.M., Franke, L., Sanna, S., D'Amato, M., Pedersen, O., et al., Kurilshikov, A., Medina-Gomez, C., Bacigalupe, R., Radjabzadeh, D., Wang, J, Demirkan, A., Roy, C.I. Le, Garay, J.A. Raygoza, Finnicum, C.T., Liu, X, Zhernakova, D.V., Bonder, M.J., Hansen, T.H., Frost, F., Rühlemann, M.C., Turpin, W., Moon, J.Y., Kim, H.N., Lüll, K., Barkan, E., Shah, S.A., Fornage, M., Szopinska-Tokov, J.W., Wallen, Z.D., Borisevich, D., Agreus, L., Andreasson, A., Bang, C., Bedrani, L., Bell, J.T., Bisgaard, H., Boehnke, M., Boomsma, D.I., Burk, R.D., Claringbould, A., Croitoru, K., Davies, G.E., Duijn, C.M. van, Duijts, L., Falony, G., Fu, J., Graaf, A. de, Hansen, T., Homuth, G., Hughes, D.A., Ijzerman, R.G., Jackson, M.A., Jaddoe, V.W.V., Joossens, M., Jørgensen, T., Keszthelyi, D., Knight, R., Laakso, M., Laudes, M., Launer, L.J., Lieb, W., Lusis, A.J., Masclee, A.A.M., Moll, H.A., Mujagic, Z., Qibin, Q., Rothschild, D., Shin, H., Sørensen, S.J., Steves, C.J., Thorsen, J., Timpson, N.J., Tito, R.Y., Vieira-Silva, S., Völker, U., Völzke, H., Võsa, U., Wade, K.H., Walter, S., Watanabe, K., Weiss, S., Weiss, F.U., Weissbrod, O., Westra, H.J., Willemsen, G., Payami, H., Jonkers, D., Arias Vasquez, A., Geus, E.J.C. de, Meyer, K.A., Stokholm, J., Segal, E., Org, E., Wijmenga, C., Kim, H.L., Kaplan, R.C., Spector, T.D., Uitterlinden, A.G., Rivadeneira, F., Franke, A., Lerch, M.M., Franke, L., Sanna, S., D'Amato, M., and Pedersen, O., et al.

Abstract

Item does not contain fulltext, To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium curated and analyzed genome-wide genotypes and 16S fecal microbiome data from 18,340 individuals (24 cohorts). Microbial composition showed high variability across cohorts: only 9 of 410 genera were detected in more than 95% of samples. A genome-wide association study of host genetic variation regarding microbial taxa identified 31 loci affecting the microbiome at a genome-wide significant (P < 5 × 10(-8)) threshold. One locus, the lactase (LCT) gene locus, reached study-wide significance (genome-wide association study signal: P = 1.28 × 10(-20)), and it showed an age-dependent association with Bifidobacterium abundance. Other associations were suggestive (1.95 × 10(-10) < P < 5 × 10(-8)) but enriched for taxa showing high heritability and for genes expressed in the intestine and brain. A phenome-wide association study and Mendelian randomization identified enrichment of microbiome trait loci in the metabolic, nutrition and environment domains and suggested the microbiome might have causal effects in ulcerative colitis and rheumatoid arthritis.

Published
2021

34. Analysis of GPRC6A variants in different pancreatitis etiologies

Author

Kaune, T., Ruffert, C., Hesselbarth, N., Damm, M., Krug, S., Widdern, J. Cardinal von, Masson, E., Chen, J.M., Rebours, V., Buscail, L., Férec, C., Grützmann, R., Morsche, R.H.M. te, Drenth, J.P.H., Cavestro, G.M., Zuppardo, R.A., Saftoiu, A., Malecka-Panas, E., Głuszek, S., Bugert, P., Lerch, M.M., Sendler, M., Weiss, F.U., Zou, W.B., Deng, S.J., Liao, Z., Scholz, M., Kirsten, H., Hegyi, P., Witt, H., Michl, P., Griesmann, H., Rosendahl, J., Kaune, T., Ruffert, C., Hesselbarth, N., Damm, M., Krug, S., Widdern, J. Cardinal von, Masson, E., Chen, J.M., Rebours, V., Buscail, L., Férec, C., Grützmann, R., Morsche, R.H.M. te, Drenth, J.P.H., Cavestro, G.M., Zuppardo, R.A., Saftoiu, A., Malecka-Panas, E., Głuszek, S., Bugert, P., Lerch, M.M., Sendler, M., Weiss, F.U., Zou, W.B., Deng, S.J., Liao, Z., Scholz, M., Kirsten, H., Hegyi, P., Witt, H., Michl, P., Griesmann, H., and Rosendahl, J.

Abstract

Contains fulltext : 229360.pdf (Publisher’s version ) (Closed access), BACKGROUND: The G-protein-coupled receptor Class C Group 6 Member A (GPRC6A) is activated by multiple ligands and is important for the regulation of calcium homeostasis. Extracellular calcium is capable to increase NLRP3 inflammasome activity of the innate immune system and deletion of this proinflammatory pathway mitigated pancreatitis severity in vivo. As such this pathway and the GPRC6A receptor is a reasonable candidate gene for pancreatitis. Here we investigated the prevalence of sequence variants in the GPRC6A locus in different pancreatitis aetiologies. METHODS: We selected 6 tagging SNPs with the SNPinfo LD TAG SNP Selection tool and the functional relevant SNP rs6907580 for genotyping. Cohorts from Germany, further European countries and China with up to 1,124 patients and 1,999 controls were screened for single SNPs with melting curve analysis. RESULTS: We identified an association of rs1606365(G) with alcoholic chronic pancreatitis in a German (odds ratio (OR) 0.76, 95% confidence interval (CI) 0.65-0.89, p = 8 × 10(-5)) and a Chinese cohort (OR 0.78, 95% CI 0.64-0.96, p = 0.02). However, this association was not replicated in a combined cohort of European patients (OR 1.18, 95% CI 0.99-1.41, p = 0.07). Finally, no association was found with acute and non-alcoholic chronic pancreatitis. CONCLUSIONS: Our results support a potential role of calcium sensing receptors and inflammasome activation in alcoholic chronic pancreatitis development. As the functional consequence of the associated variant is unclear, further investigations might elucidate the relevant mechanisms.

Published
2020

35. The UEG Journal is steaming ahead

Author

Drenth, J.P.H., Lerch, M.M., Drenth, J.P.H., and Lerch, M.M.

Abstract

Contains fulltext : 229333.pdf (Publisher’s version ) (Open Access)

Published
2020

38. Autorenverzeichnis

Author

Domschke, W., primary, Berger, M., additional, Hohenberger, W., additional, Meinertz, T., additional, Vogelmeier, C., additional, Domschke, W., additional, Sauerbruch, T., additional, Kramer, H.J., additional, Müller, S.C., additional, Serve, H., additional, Weber, M.M., additional, Göke, B., additional, Kalden, J.R., additional, Manger, B., additional, Rascher, W., additional, Appenrodt, B., additional, Atta, J., additional, Auernhammer, C., additional, Autenrieth, I.B., additional, Avenhaus, W., additional, Backmund, M., additional, Bausewein, C., additional, Behr, J., additional, Behrens, A., additional, Berner, R., additional, Berr, F., additional, Blank, N., additional, Blind, E., additional, Bockhorn, M., additional, Bokemeyer, D., additional, Böhm, M., additional, Bönner, G., additional, Borasio, G.D., additional, Bork, K., additional, Braun, J., additional, Bruch, H.-P., additional, Brümmendorf, T.H., additional, Brunnberg, U., additional, Brüwer, M., additional, Büchler, M.W., additional, Detter, C., additional, Diederich, S., additional, Diehm, C., additional, Distler, J., additional, Domagk, D., additional, Dörner, T., additional, Dörr, H.-G., additional, Dralle, H., additional, Dreyling, M., additional, Ehlebracht-König, I., additional, Ell, C., additional, Enzensberger, W., additional, Epple, H.-J., additional, Fassnacht, M., additional, Feußner, H., additional, Fiegel, P., additional, Fisang, C., additional, Filipas, D., additional, Fischbach, W., additional, Flamme, C.H., additional, Floege, J., additional, Fölsch, U.R., additional, Fottner, C., additional, Frank, W., additional, Frey, N., additional, Friese, K., additional, Frilling, A., additional, Fröhner, M., additional, Frühmorgen, P., additional, Galle, P.R., additional, Geidel, S., additional, Genth, E., additional, Gingelmaier, A., additional, Goebel, F.-D., additional, Gökbuget, N., additional, Göke, R., additional, Grabitz, K., additional, Grünke, M., additional, Hahner, S., additional, Handrick, W., additional, Hasslacher, C., additional, Heidbreder, E., additional, Heindel, W., additional, Heinemann, V., additional, Heitmann, J., additional, Heiß, H.W., additional, Hof, H., additional, Hering, L., additional, Hiller, E., additional, Hirner, A., additional, Hofmann, W.-K., additional, Holler, E., additional, Hölscher, A.H., additional, Holtmann, G., additional, Hölzen, J., additional, Honegger, J., additional, Hörle, S., additional, Hörmann, K., additional, Hörmann, R., additional, Hornke, I., additional, Huber, R.M., additional, Hübner, J., additional, Hummel, R., additional, Irmscher, S., additional, Jelinek, T., additional, Jonas, S., additional, Jost, E., additional, Jung, H.H., additional, Kahaly, G.J., additional, Karaus, M., additional, Katsoulis, S., additional, Katus, H., additional, Kessler, H.P., additional, Kiehne, K., additional, Kiess, W., additional, Kindermann, M., additional, von Kodolitsch, Y., additional, Köhler, H., additional, Köhler, L., additional, Köhler, M., additional, Kohne, E., additional, Kolb, H.-J., additional, Köninger, J., additional, Koop, K., additional, Köster, R., additional, Kötter, I., additional, Kramer, H.J.J., additional, Kremer, B., additional, Kroll, P., additional, Kuipers, J.G., additional, Lammert, F., additional, Langer, M., additional, Laukötter, M., additional, Lehnert, H., additional, Lembcke, B., additional, Lerch, M.M., additional, Liebe, S., additional, Lieber, A., additional, Loddenkemper, R., additional, Löhr, M., additional, Lorenz, H.-M., additional, Lorenz, J., additional, Löscher, T., additional, Luster, M., additional, Lux, G., additional, Mann, K., additional, Mayerle, J., additional, Merle, U., additional, Meyer, H.-J., additional, Möbius, C., additional, Moehler, M., additional, Mönnikes, H., additional, Mössner, J., additional, Müller, S.A., additional, Musholt, T.J., additional, Nattermann, J., additional, Neubrand, M., additional, Neuhaus, P., additional, Neundörfer, B., additional, Nicolai, T., additional, Nolde, J., additional, Olschewski, H., additional, Ostermeyer, J., additional, Ott, C., additional, Pahernik, S., additional, Pankratius, U., additional, Parhofer, K.G., additional, Passlick, B., additional, Pech, O., additional, Pfaffenbach, B., additional, Pfeiffer, T., additional, Pilatz, A., additional, Pohle, T., additional, Pohl-Koppe, A., additional, Ponto, Katharina A., additional, Prange, H., additional, Pruß, A., additional, Rädle, J., additional, Rauch, B., additional, Raue, F., additional, Reichel, C., additional, Reindl, C., additional, Reißfelder, C., additional, Rendl, Dipl.-Phys. J., additional, Rietschel, E., additional, Rijcken, E., additional, Roos, R., additional, Rudofsky†, G., additional, Samtleben, W., additional, Sandmann, W., additional, Sauter, G., additional, Schaal, K.P., additional, Schaefer, J.R., additional, Schäfer-Graf, U., additional, Schepp, W., additional, Schlemmer, M., additional, Schliep, S., additional, Schmidt, H., additional, Schmied, B., additional, Schmiegel, W., additional, Schießl, A., additional, Schmid, A., additional, Schneider, A., additional, Schneider, T., additional, Schölmerich, J., additional, Scholz, H., additional, Schönermarck, U., additional, Schopohl, J., additional, Schrezenmeier, H., additional, Schulze-Koops, H., additional, Schuppan, D., additional, Schuster, V., additional, Schüßler, G., additional, Schwandner, O., additional, Schwarz, T.F., additional, Secknus, R., additional, Senninger, N., additional, Sezer, O., additional, Simmen, B.R., additional, Spengler, U., additional, Stabenow-Lohbauer, U., additional, Stebler, R., additional, Steven, D., additional, Sticherling, M., additional, Strauch, U., additional, Stremmel, C., additional, Stremmel, W., additional, Stuck, B.A., additional, Stürz, H., additional, Taube, C., additional, Thulesius, O., additional, Thurau, K., additional, Thüroff, J.W., additional, Tomiak, C., additional, Uhl, W., additional, Vallböhmer, D., additional, Vogel, T., additional, von den Driesch, P., additional, Wagenlehner, F.M.E., additional, Wagner, A., additional, Wagner, U., additional, Weber, K., additional, Weidner, W., additional, Weinke, T., additional, Weis-Müller, B.T., additional, Weiß, M., additional, Willems, S., additional, Wintergerst, U., additional, Wirth, M., additional, Wolkersdörfer, G.W., additional, and Zeitz, M., additional

Published
2011
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43. The N34S mutation of SPINK1 (PSTI) is associated with a familial pattern of idiopathic chronic pancreatitis but does not cause the disease. (Pancreatitis)

Author

Threadgold, J., Greenhalf, W., Ellis, I., Howes, N., Lerch, M.M., Simon, P., Jansen, J., Charnley, R., Laugier, R., Frulloni, L., Olah, A., Delhaye, M., Ihse, I., Muckadell, O.B. Schaffalitzky de, Andren-Sandberg, A., Imrie, C.W., Martinek, J., Gress, T.M., Mountford, R., Whitcomb, D., and Neoptolemos, J.P.

Subjects
Pancreatitis -- Genetic aspects, Health, Genetic aspects
Abstract

Background: Mutations in the PRSS1 gene explain most occurrences of hereditary pancreatitis (HP) but many HP families have no PRSS1 mutation. Recently, an association between the mutation N34S in the [...]

Published
2002

46. Corrigendum to “Recommendations from the United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis” [Pancreatology 18(8) (2018) 847–854]

Author

Dominguez-Munoz, J.E., primary, Drewes, A.M., additional, Lindkvist, B., additional, Ewald, N., additional, Czakó, L., additional, Rosendahl, J., additional, Löhr, J.M., additional, Löhr, M., additional, Dominguez-Munoz, J.E., additional, Besselink, M., additional, Mayerle, J., additional, Lerch, M.M., additional, Akisik, F., additional, Kartalis, N., additional, Manfredi, R., additional, Iglesias-Garcia, J., additional, Haas, S.L., additional, Keller, J., additional, Boermeester, M.A., additional, Werner, J., additional, Dumonceau, J.M., additional, Fockens, P., additional, Drewes, A., additional, Cheyan, G.O., additional, Drenth, J.P., additional, Hardt, P., additional, de Madaria, E., additional, Gheorghe, C., additional, Lindgren, F., additional, Schneider, A., additional, Witt, H., additional, Bollen, T., additional, Boraschi, P., additional, Frøkjær, J.B., additional, Rudolf, S., additional, Bruno, M., additional, Dimcevski, G., additional, Giovannini, M., additional, Pukitis, A., additional, Petrone, M., additional, Oppong, K., additional, Ammori, B., additional, Friess, H., additional, Izbiki, J.R., additional, Ganeh, P., additional, Salvia, R., additional, Sauvanet, A., additional, Barbu, S., additional, Lyadov, V., additional, Deprez, P., additional, Gubergrits, N., additional, Okhlobystiy, A.V., additional, Arvanitakis, M., additional, Costamagna, G., additional, Pap, A., additional, Andersson, R., additional, Hauge, T., additional, McKay, C., additional, Regnér, S., additional, Dite, P., additional, Olesen, S.S., additional, Duggan, S., additional, Hopper, A., additional, Phillips, M., additional, Shvets, O., additional, Vujasinovic, M., additional, Czako, L., additional, Piemonti, L., additional, Kocher, H., additional, Rebours, V., additional, Stimac, D., additional, and Hegyi, P., additional

Published
2020
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47. Zymogen proteolysis within the pancreatic acinar cell is associated with cellular injury

Author

Grady, T., Mah'moud, M., Otani, T., Rhee, S., Lerch, M.M., and Gorelick, F.S.

Subjects
Bombesin -- Physiological aspects, Cholecystokinin -- Physiological aspects, Pancreas -- Injuries, Pancreatitis -- Research, Proteolysis -- Research, Biological sciences
Abstract

Isolated pancreatic acini were employed to investigate the ability of digestive zymogen activation to cause cellular damage in the absence of other factors such as inflammation and hypoxemia. Findings showed that both cholecystokinin hyperstimulation and bombesin stimulation of isolated acini caused the processing of trypsinogen to trypsin. These treatments also caused the proteolytic processing of procarboxypeptidase A1 to carboxypeptidase A1.

Published
1998

48. Intra-acinar cell activation of trypsinogen during caerulein-induced pancreatitis in rats

Author

Hofbauer, B., Saluja, A.K., Lerch, M.M., Bhagat, L., Bhatia, M., Lee, H.S., Frossard, J.L., Adler, G., and Steer, M.L.

Subjects
Pancreatitis -- Physiological aspects, Rats -- Physiological aspects, Trypsin -- Physiological aspects, Enzymes -- Physiological aspects, Biological sciences
Abstract

A model of secretagogue-induced pancreatitis to determine the identity of the intrapancreatic site of trypsinogen activation and what happens with activated trypsin. Subcellular fractionation and both light and electron microscopy immunolocalization were employed. Findings indicated that in response to supramaximal secretagogue stimulation, trypsinogen is activated in a particulate intracellular site that is most likely made of cytoplasmic vacuoles.

Published
1998

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