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1. Comments on “Preventive home therapy for symptomatic patients affected by COVID-19 and followed by teleconsultations” by D'Amato et al

Author

Adiletta, G, Baglioni, S, Bettoncelli, G, Bracciale, P, Cazzola, M, Clini, E, Cutrera, R, D'Adduzio, F, de Blasio, F, Ferraro, F, Fumagalli, R, Lequaglie, C, Matera, M, Numis, F, Palange, P, Picciolo, S, Potena, A, Romano, F, Sabato, E, Sacchetta, A, Spatafora, M, Stefanelli, F, Zottola, C, Adiletta G., Baglioni S., Bettoncelli G., Bracciale P., Cazzola M., Clini E. M., Cutrera R., D'Adduzio F., de Blasio F., Ferraro F., Fumagalli R., Lequaglie C., Matera M. G., Numis F., Palange P., Picciolo S., Potena A., Romano F., Sabato E., Sacchetta A., Spatafora M., Stefanelli F., Zottola C., Adiletta, G, Baglioni, S, Bettoncelli, G, Bracciale, P, Cazzola, M, Clini, E, Cutrera, R, D'Adduzio, F, de Blasio, F, Ferraro, F, Fumagalli, R, Lequaglie, C, Matera, M, Numis, F, Palange, P, Picciolo, S, Potena, A, Romano, F, Sabato, E, Sacchetta, A, Spatafora, M, Stefanelli, F, Zottola, C, Adiletta G., Baglioni S., Bettoncelli G., Bracciale P., Cazzola M., Clini E. M., Cutrera R., D'Adduzio F., de Blasio F., Ferraro F., Fumagalli R., Lequaglie C., Matera M. G., Numis F., Palange P., Picciolo S., Potena A., Romano F., Sabato E., Sacchetta A., Spatafora M., Stefanelli F., and Zottola C.

Published
2021

5. The IASLC/ITMIG Thymic Epithelial Tumors Staging Project: Proposals for the T component for the Forthcoming (8th) Edition of the TNM Classification of Malignant Tumors

Author

Okuma, Y, Horio, H, Matsumura, A, Higashiyama, M, Suehisa, H, Onuki, T, Sano, Y, Kondo, K, Al Kattan, K, Cerfolio, R, Gebitekin, C, de Antonio, D, Kernstine, Kh, Altorki, N, Novoa, N, Ruffini, E, Filosso, Pl, Saita, S, Scarci, M, Voltolini, L, Weder, W, Zurek, W, Arame, A, Casadio, C, Carbognani, P, Donati, G, Keshavjee, S, Klepetko, W, Moser, B, Lequaglie, C, Liberman, M, Mancuso, M, Nosotti, M, Spaggiari, L, Thomas, Pa, Rendina, Erino Angelo, Venuta, Federico, Anile, Marco, Schützner, J, Rocco, G., Staging Prognostic Factors Comm, Advisory Boards, Participating Inst Thymic Domain, University of Zurich, and Detterbeck, Frank C

Subjects
Humans, Neoplasm Staging, Neoplasms, Glandular and Epithelial, Prognosis, Thymus Neoplasms, Pulmonary and Respiratory Medicine, Stage classification, Lymphatic metastasis, medicine.medical_specialty, Pathology, Staging, Thymoma, 10255 Clinic for Thoracic Surgery, 610 Medicine & health, M Components, Thymic carcinoma, Neoplasms, medicine, Survival analysis, Nodal involvement, business.industry, Glandular and Epithelial, Cancer, medicine.disease, Oncology, 2740 Pulmonary and Respiratory Medicine, 2730 Oncology, Human medicine, Radiology, business
Abstract

Despite longstanding recognition of thymic epithelial neoplasms, there is no official American Joint Committee on Cancer/Union for International Cancer Control stage classification. This article summarizes proposals for classification of the T component of stage classification for use in the 8th edition of the tumor, node, metastasis classification for malignant tumors. This represents the output of the International Association for the Study of Lung Cancer and the International Thymic Malignancies Interest Group Staging and Prognostics Factor Committee, which assembled and analyzed a worldwide database of 10,808 patients with thymic malignancies from 105 sites. The committee proposes division of the T component into four categories, representing levels of invasion. T1 includes tumors localized to the thymus and anterior mediastinal fat, regardless of capsular invasion, up to and including infiltration through the mediastinal pleura. Invasion of the pericardium is designated as T2. T3 includes tumors with direct involvement of a group of mediastinal structures either singly or in combination: lung, brachiocephalic vein, superior vena cava, chest wall, and phrenic nerve. Invasion of more central structures constitutes T4: aorta and arch vessels, intrapericardial pulmonary artery, myocardium, trachea, and esophagus. Size did not emerge as a useful descriptor for stage classification. This classification of T categories, combined with a classification of N and M categories, provides a basis for a robust tumor, node, metastasis classification system for the 8th edition of American Joint Committee on Cancer/Union for International Cancer Control stage classification.

Published
2014

6. The IASLC/ITMIG Thymic Epithelial Tumors Staging Project: proposal for an evidence-based stage classification system for the forthcoming (8th) edition of the TNM classification of malignant tumors

Author

Rosenberg, M, Tomulescu, V, Huang, J, Foroulis, C, Lang Lazdunski, L, Billè, A, Maessen, Jg, Keijzers, M, van Veer, H, Wright, C, Marino, M, Facciolo, F, Palmieri, G, Buonerba, C, Ferguson, M, Marulli, G, Lucchi, M, Loehrer, P, Kalkat, M, Rohrberg, K, Daugaard, G, Toker, A, Erus, S, Kimmich, M, Brunelli, A, Refai, M, Nicholson, A, Lim, E, Park, Ik, Wagner, J, Tieu, B, Fang, W, Zhang, J, Yu, Z, Han, Y, Li, Y, Chen, K, Chen, G, Okumura, M, Fujii, Y, Asamura, H, Nagai, K, Nakajima, J, Ikeda, N, Haraguchi, S, Onuki, T, Suzuki, K, Yoshino, I, Tsuchida, M, Takahashi, S, Yokoi, K, Hanyuda, M, Niwa, H, Date, H, Maniwa, Y, Miyoshi, S, Kondo, K, Iwasaki, A, Okamoto, T, Nagayasu, T, Tanaka, F, Suzuki, M, Yoshida, K, Okuma, Y, Horio, H, Matsumura, A, Higashiyama, M, Suehisa, H, Sano, Y, Al Kattan, K, Cerfolio, R, Gebitekin, C, de Antonio, D, Kernstine, Kh, Altorki, N, Novoa, N, Ruffini, E, Filosso, Pl, Saita, S, Scarci, M, Voltolini, L, Weder, W, Zurek, W, Arame, A, Casadio, C, Carbognani, P, Donati, G, Keshavjee, S, Klepetko, W, Moser, B, Lequaglie, C, Liberman, M, Mancuso, M, Nosotti, M, Spaggiari, L, Thomas, Pa, Rendina, Erino Angelo, Venuta, Federico, Anile, Marco, Schützner, J, Rocco, G, Crowley, J, Detterbeck, F, Falkson, C, Filosso, L, Giaccone, G, Giroux, D, Kim, J, Marom, Em, Nicholson, Ag, Brompton, R, Van Schil, P, Stratton, K., University of Zurich, Detterbeck, Frank C, Eberhardt, Wilfried (Beitragende*r), Prognostic Factors Comm, Advisory Boards, and Participating Inst Thymic Domain

Subjects
Pulmonary and Respiratory Medicine, Stage classification, Oncology, medicine.medical_specialty, Pathology, Staging, Thymoma, Evidence-based practice, 10255 Clinic for Thoracic Surgery, Medizin, 610 Medicine & health, Metastasis, Thymic carcinoma, Cohort Studies, Neoplasms, Internal medicine, medicine, Humans, Neoplasms, Glandular and Epithelial, Stage (cooking), Lung cancer, Neoplasm Staging, Retrospective Studies, Evidence-Based Medicine, business.industry, Glandular and Epithelial, Cancer, Thymus Neoplasms, Prognosis, medicine.disease, 2740 Pulmonary and Respiratory Medicine, 2730 Oncology, Human medicine, business
Abstract

A universal and consistent stage classification system, which describes the anatomic extent of a cancer, provides a foundation for communication and collaboration. Thymic epithelial malignancies have seen little progress, in part because of the lack of an official system. The International Association for the Study of Lung Cancer and the International Thymic Malignancies Interest Group assembled a large retrospective database, a multispecialty international committee and carried out extensive analysis to develop proposals for the 8th edition of the stage classification manuals. This tumor, node, metastasis (TNM)-based system is applicable to all types of thymic epithelial malignancies. This article summarizes the proposed definitions of the T, N, and M components and describes how these are combined into stage groups. This represents a major step forward for thymic malignancies.

Published
2014

7. The IASLC/ITMIG thymic malignancies staging project: development of a stage classification for thymic malignancies

Author

Detterbeck, Fc1, Asamura, H, Crowley, J, Falkson, C, Giaccone, G, Giroux, D, Huang, J, Kim, J, Kondo, K, Lucchi, M, Marino, M, Marom, Em, Nicholson, A, Okumura, M, Ruffini, E, van Schil, P, Stratton, K, Staging, Prognostic Factors Committee, Members of the Advisory Boards, Goldstraw P, Participating Institutions of the Thymic D. o. m. a. i. n., Rami Porta, R, Ball, D, Beer, D, Beyruti, R, Bolejack, V, Chansky, K, Detterbeck, F, Eberhardt, W, Edwards, J, Galateau Sallé, F, Gleeson, F, Groome, P, Kennedy, C, Kim, Y, Kingsbury, L, Kondo, H, Krasnik, M, Kubota, K, Lerut, A, Lyons, G, Marom, E, van Meerbeeck, J, Mitchell, A, Nakano, T, Newman, J, Nowak, A, Peake, M, Rice, T, Rosenzweig, K, Rusch, V, Sculier, Jp, Suzuki, K, Tachimori, Y, Thomas CF Jr, Travis, W, Tsao, M, Turrisi, A, Vansteenkiste, J, Watanabe, H, Wu, Yi, Zielinski, M, Filosso, L, Baas, P, Erasmus, J, Hasegawa, S, Inai, K, Kernstine, K, Kindler, H, Krug, L, Nackaerts, K, Pass, H, Rice, D, Blackstone, E, Call Caja, S, Ahmad, U, Girard, N, Haam, Sj, Bae, Mk, Gomez, Dr, Ströbel, P, Marx, A, Saita, S, Wakelee, H, Bertolaccini, L, Vallieres, E, Scott, W, Su, S, Park, B, Marks, J, Khella, S, Shen, R, Rosenberg, M, Aires, B, Tomulescu, V, Foroulis, C, Lang Lazdunski, L, Billè, A, Maessen, Jg, Keijzers, M, van Veer, H, Wright, C, Palmieri, G, Buonerba, C, Ferguson, M, Marulli, G, Loehrer, P, Kalkat, M, Rohrberg, K, Daugaard, G, Toker, A, Erus, S, Kimmich, M, Brunelli, A, Refai, M, Lim, E, Park, Ik, Wagner, J, Tieu, B, Fang, W, Zhang, J, Yu, Z, Han, Y, Li, Y, Chen, K, Chen, G, Fujii, Y, Nagai, K, Nakajima, J, Ikeda, N, Haraguchi, S, Onuki, T, Yoshino, I, Tsuchida, M, Takahashi, S, Yokoi, K, Hanyuda, M, Niwa, H, Date, H, Maniwa, Y, Miyoshi, S, Iwasaki, A, Okamoto, T, Nagayasu, T, Tanaka, F, Suzuki, M, Yoshida, K, Okuma, Y, Horio, H, Matsumura, A, Higashiyama, M, Suehisa, H, Sano, Y, Kattan, K, Cerfolio, R, Gebitekin, C, de Antonio, D, Kernstine, Kh, Altorki, N, Novoa, N, Filosso, Pl, Scarci, M, Voltolini, L, Weder, W, Zurek, W, Arame, A, Casadio, C, Toracica, C, Carbognani, P, Donati, G, Keshavjee, S, Klepetko, W, Moser, B, Lequaglie, C, Liberman, M, Mancuso, M, Nosotti, M, Spaggiari, L, Thomas, Pa, Rendina, Erino Angelo, Venuta, F, Anile, M, Schützner, J, Rocco, G., Staging Prognostic Factors Comm, University of Zurich, Detterbeck, Frank C, and Eberhardt, Wilfried (Beitragende*r)

Subjects
Pulmonary and Respiratory Medicine, Oncology, Stage classification, medicine.medical_specialty, Pathology, Lung Neoplasms, Thymoma, 10255 Clinic for Thoracic Surgery, Medizin, 610 Medicine & health, Thymic carcinoma, Internal medicine, medicine, Humans, Project management, Program Development, Lung cancer, Neoplasm Staging, business.industry, International Agencies, Thymus Neoplasms, Staging of stage classification, medicine.disease, 2740 Pulmonary and Respiratory Medicine, Interest group, 2730 Oncology, Program development, Human medicine, business
Abstract

The lack of an official-stage classification system for thymic malignancies is an issue that hampers progress in this rare disease. A collaborative effort by the International Association for the Study of Lung Cancer and the International Thymic Malignancies Interest Group is underway to develop proposals for such a system. A database of more than 10,000 cases worldwide has been assembled to provide a solid basis for analysis. This report outlines the structure of the effort and the process that has been designed.

Published
2014

8. Efficacy and safety of fibrin sealant patch in the treatment of air leakage in thoracic surgery

Author

Lopez, C, Facciolo, F, Lequaglie, C, Rendina, Erino Angelo, Saita, S, Dell'Amore, D, Sollitto, F, Urciuoli, G, Loizzi, M, Cisternino, Ml, Granone, P, Angelelli, A, Cardillo, G, Mucilli, F, and Di Rienzo, G.

Subjects
Male, Lung Neoplasms, fibrin sealant patch, Settore MED/21 - CHIRURGIA TORACICA, Air, Humans, Anastomotic Leak, Female, Fibrin Tissue Adhesive, Prospective Studies, Thoracic Surgical Procedures, Pneumonectomy, Aged
Abstract

Air leakage represents a major problem in lung surgery. Absorbable fibrin sealant patch (AFSP), a collagen sponge coated with human fibrinogen and thrombin, can be used as an adjunct to primary stapling or suturing. This study compared the efficacy of AFSP with manual suturing after primary stapling.This was a prospective, multicenter, randomized study. Patients undergoing lobectomy, bilobectomy, anatomical segmentectomy for lung cancer or wedge resection for pulmonary metastasis with air leakage grade 1 or 2 according to Macchiarini scale after stapler suture were randomized to receive AFSP or standard surgical treatment (ST). The primary endpoint was the reduction of intraoperative air leakage intensity. Duration of postoperative air leakage and number of days until removal of last chest drain were secondary endpoints. Safety was recorded for all patients.A total of 346 patients were enrolled in 14 centres, 179 of whom received AFSP and 167 ST. Intraoperative air leak intensity was reduced in 90.5% of AFSP patients and 82% of ST patients (P=0.03). A significant reduction in postoperative air leakage duration was observed in the AFSP group (P=0.0437). The median number of days until removal of last drainage was 6 (3-37) in the AFSP group and 7 (2-27) in the ST (P=0.38). Occurrence of adverse events was comparable in both groups.AFSP was more efficacious than standard ST as an adjunct to primary stapling in reducing intraoperative air leakage intensity and duration of postoperative air leakage in patients undergoing pulmonary surgery. AFSP was well tolerated.

Published
2013

10. Personal experience with 120 sternal resections

Author

Lequaglie, C and Giudice, G

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: To target the gold standard to sternal resections for cancer even in extreme situations. Methods: We review our experience during last 25 years, 112 patients (37 males with a mean age of 49 years: range 16–82, and 75 females with a mean age of 52 years: range 22–78) underwent[for full text, please go to the a.m. URL], 18. Jahrestagung der Deutschen Gesellschaft für Thoraxchirurgie

Published
2009
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11. QOL and efficacy of uniportal VATS for malignant pleural effusions

Author

Giudice, G, Lequaglie, C, Garramone, M, and Marasco, D

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: To determine the safety and long and medium term efficacy of pleurodesis by video-assisted-thoracoscopic (VATS) talc poudrage, as well as its impact on the respiratory function and therefore on the quality of life of the patients with the patient grade of benefit. Methods: The clinical[for full text, please go to the a.m. URL], 18. Jahrestagung der Deutschen Gesellschaft für Thoraxchirurgie

Published
2009
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12. Efficacy and safety of fibrin sealant patch in the treatment of air leakage in thoracic surgery.

Author

Granone, Pierluigi, Lopez, C, Facciolo, F, Lequaglie, C, Rendina, Ea, Saita, S, Dell'Amore, D, Sollitto, F, Urciuoli, F, Loizzi, M, Cisternino, Ml, Angelelli, A, Cardillo, G, Mucilli, F, Di Rienzo, G., Granone, Pierluigi (ORCID:0000-0002-8826-3045), Granone, Pierluigi, Lopez, C, Facciolo, F, Lequaglie, C, Rendina, Ea, Saita, S, Dell'Amore, D, Sollitto, F, Urciuoli, F, Loizzi, M, Cisternino, Ml, Angelelli, A, Cardillo, G, Mucilli, F, Di Rienzo, G., and Granone, Pierluigi (ORCID:0000-0002-8826-3045)

Abstract

AIM: Air leakage represents a major problem in lung surgery. Absorbable fibrin sealant patch (AFSP), a collagen sponge coated with human fibrinogen and thrombin, can be used as an adjunct to primary stapling or suturing. This study compared the efficacy of AFSP with manual suturing after primary stapling. METHODS: This was a prospective, multicenter, randomized study. Patients undergoing lobectomy, bilobectomy, anatomical segmentectomy for lung cancer or wedge resection for pulmonary metastasis with air leakage grade 1 or 2 according to Macchiarini scale after stapler suture were randomized to receive AFSP or standard surgical treatment (ST). The primary endpoint was the reduction of intraoperative air leakage intensity. Duration of postoperative air leakage and number of days until removal of last chest drain were secondary endpoints. Safety was recorded for all patients. RESULTS: A total of 346 patients were enrolled in 14 centres, 179 of whom received AFSP and 167 ST. Intraoperative air leak intensity was reduced in 90.5% of AFSP patients and 82% of ST patients (P=0.03). A significant reduction in postoperative air leakage duration was observed in the AFSP group (P=0.0437). The median number of days until removal of last drainage was 6 (3-37) in the AFSP group and 7 (2-27) in the ST (P=0.38). Occurrence of adverse events was comparable in both groups. CONCLUSION: AFSP was more efficacious than standard ST as an adjunct to primary stapling in reducing intraoperative air leakage intensity and duration of postoperative air leakage in patients undergoing pulmonary surgery. AFSP was well tolerated.

Published
2013

30. Bcl-2 protein and prognosis in patients with potentially curable non-small-cell lung cancer.

Author

Silvestrini, R., Costa, Aurora, Lequaglie, Cosimo, Mochen, Claudia, Veneroni, Silvia, Leutner, Monica, Ravasi, Gianni, Costa, A, Lequaglie, C, Mochen, C, Veneroni, S, Leutner, M, and Ravasi, G

Abstract

The bcl-2 proto-oncogene functions as a cell death suppressor, and its expression prolongs cell survival by blocking apoptosis. Data available on the clinical relevance of bcl-2 protein expression in patients with non-small-cell lung cancer (NSCLC) are controversial. We analysed the role of bcl-2 protein expression on 6-year relapse-free survival in 229 patients with stage I-IIIa NSCLC (101 squamous cell carcinomas and 128 adenocarcinomas) subjected to surgery, with curative intent. Immunohistochemical analysis was performed on archival material by using a monoclonal antibody anti-bcl-2 (clone 124). Bcl-2 protein expression, which was detected in 22% of the cases, was significantly related to stage, histology and grading, and was an indicator of clinical outcome. The probability of relapse-free survival at 6 years was longer for patients with bcl-2-positive tumours (74%) than for those with bcl-2-negative tumours (57%) (P=0.02). This finding was mainly evident for the subgroups of patients with stage IIIa tumours (P=0.05), squamous cell carcinoma (P=0.03) or moderately/poorly differentiated tumours (P=0.02). However, multivariate analysis by Weibull's regression model indicated that bcl-2 protein expression was not an independent prognostic risk factor in patients with curable NSCLC when the information provided by stage was available. [ABSTRACT FROM AUTHOR]

Published
1998
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33. The IASLC/ITMIG thymic epithelial tumors staging project: Proposals for the N and M components for the forthcoming (8th) edition of the TNM classification of malignant tumors

Author

Kondo, K., Schil, P., Detterbeck, F. C., Okumura, M., Giroux, D., Asamura, H., Crowley, J., Falkson, C., Pier Luigi Filosso, Giaccone, G., Huang, J., Kim, J., Lucchi, M., Marino, M., Marom, E. M., Nicholson, A. G., Ruffini, E., Goldstraw, P., Rami-Porta, R., Ball, D., Beer, D., Beyruti, R., Bolejack, V., Chansky, K., Eberhardt, W. E. E., Edwards, J., Galateau-Sallé, F., Gleeson, F., Groome, P., Kennedy, C., Kingsbury, L., Kim, Y. T., Kondo, H., Krasnik, M., Kubota, K., Lerut, A., Lyons, G., Meerbeeck, J., Mitchell, A., Nakano, T., Nowak, A., Peake, M., Rice, T., Rosenzweig, K., Rusch, V., Saijo, N., Sculier, J. -P, Shemanski, L., Stratton, K., Suzuki, K., Tachimori, Y., Thomas, C. F., Travis, W., Tsao, M. S., Turrisi, A., Vansteenkiste, J., Watanabe, H., Wu, Y. -L, Baas, P., Erasmus, J., Hasegawa, S., Inai, K., Kernstine, K., Kindler, H., Krug, L., Nackaerts, K., Pass, H., Rice, D., Blackstone, E., Call Caja, S., Ahmad, U., Detterbeck, F., Girard, N., Haam, S. J., Gomez, D. R., Bae, M. K., Ströbel, P., Marx, A., Saita, S., Wakelee, H., Bertolaccini, L., Vallieres, E., Scott, W., Su, S., Park, B., Marks, J., Khella, S., Shen, R., Rosenberg, M., Tomulescu, V., Foroulis, C., Lang-Lazdunski, L., Billè, A., Maessen, J. G., Keijzers, M., Veer, H., Wright, C., Facciolo, F., Palmieri, G., Buonerba, C., Ferguson, M., Marulli, G., Loehrer, P., Kalkat, M., Rohrberg, K., Daugaard, G., Toker, A., Erus, S., Kimmich, M., Brunelli, A., Refai, M., Nicholson, A., Lim, E., Park, I. K., Wagner, J., Tieu, B., Fang, W., Zhang, J., Yu, Z., Han, Y., Li, Y., Chen, K., Chen, G., Nagai, K., Fujii, Y., Nakajima, J., Ikeda, N., Haraguchi, S., Onuki, T., Yoshino, I., Tsuchida, M., Takahashi, S., Yokoi, K., Hanyuda, M., Niwa, H., Date, H., Maniwa, Y., Miyoshi, S., Iwasaki, A., Okamoto, T., Nagayasu, T., Tanaka, F., Suzuki, M., Yoshida, K., Okuma, Y., Horio, H., Matsumura, A., Higashiyama, M., Suehisa, H., Sano, Y., Al Kattan, K., Cerfolio, R., Gebitekin, C., Gomez Antonio, D., Kernstine, K. H., Altorki, N., Novoa, N., Filosso, P. L., Scarci, M., Voltolini, L., Weder, W., Zurek, W., Arame, A., Casadio, C., Carbognani, P., Donati, G., Keshavjee, S., Klepetko, W., Moser, B., Lequaglie, C., Liberman, M., Mancuso, M., Nosotti, M., Spaggiari, L., Thomas, P. A., Rendina, E., Venuta, F., Anile, M., Schützner, J., and Rocco, G.

34. The IASLC/ITMIG thymic epithelial tumors staging project: Proposals for the N and M components for the forthcoming (8th) edition of the TNM classification of malignant tumors

Author

Kondo, K., Schil, P., Detterbeck, F. C., Okumura, M., Giroux, D., Asamura, H., Crowley, J., Falkson, C., Filosso, P. L., Giuseppe Giaccone, Huang, J., Kim, J., Lucchi, M., Marino, M., Marom, E. M., Nicholson, A. G., Ruffini, E., Goldstraw, P., Rami-Porta, R., Ball, D., Beer, D., Beyruti, R., Bolejack, V., Chansky, K., Eberhardt, W. E. E., Edwards, J., Galateau-Sallé, F., Gleeson, F., Groome, P., Kennedy, C., Kingsbury, L., Kim, Y. T., Kondo, H., Krasnik, M., Kubota, K., Lerut, A., Lyons, G., Meerbeeck, J., Mitchell, A., Nakano, T., Nowak, A., Peake, M., Rice, T., Rosenzweig, K., Rusch, V., Saijo, N., Sculier, J. -P, Shemanski, L., Stratton, K., Suzuki, K., Tachimori, Y., Thomas, C. F., Travis, W., Tsao, M. S., Turrisi, A., Vansteenkiste, J., Watanabe, H., Wu, Y. -L, Baas, P., Erasmus, J., Hasegawa, S., Inai, K., Kernstine, K., Kindler, H., Krug, L., Nackaerts, K., Pass, H., Rice, D., Blackstone, E., Call Caja, S., Ahmad, U., Detterbeck, F., Girard, N., Haam, S. J., Gomez, D. R., Bae, M. K., Ströbel, P., Marx, A., Saita, S., Wakelee, H., Bertolaccini, L., Vallieres, E., Scott, W., Su, S., Park, B., Marks, J., Khella, S., Shen, R., Rosenberg, M., Tomulescu, V., Foroulis, C., Lang-Lazdunski, L., Billè, A., Maessen, J. G., Keijzers, M., Veer, H., Wright, C., Facciolo, F., Palmieri, G., Buonerba, C., Ferguson, M., Marulli, G., Loehrer, P., Kalkat, M., Rohrberg, K., Daugaard, G., Toker, A., Erus, S., Kimmich, M., Brunelli, A., Refai, M., Nicholson, A., Lim, E., Park, I. K., Wagner, J., Tieu, B., Fang, W., Zhang, J., Yu, Z., Han, Y., Li, Y., Chen, K., Chen, G., Nagai, K., Fujii, Y., Nakajima, J., Ikeda, N., Haraguchi, S., Onuki, T., Yoshino, I., Tsuchida, M., Takahashi, S., Yokoi, K., Hanyuda, M., Niwa, H., Date, H., Maniwa, Y., Miyoshi, S., Iwasaki, A., Okamoto, T., Nagayasu, T., Tanaka, F., Suzuki, M., Yoshida, K., Okuma, Y., Horio, H., Matsumura, A., Higashiyama, M., Suehisa, H., Sano, Y., Al Kattan, K., Cerfolio, R., Gebitekin, C., Gomez Antonio, D., Kernstine, K. H., Altorki, N., Novoa, N., Scarci, M., Voltolini, L., Weder, W., Zurek, W., Arame, A., Casadio, C., Carbognani, P., Donati, G., Keshavjee, S., Klepetko, W., Moser, B., Lequaglie, C., Liberman, M., Mancuso, M., Nosotti, M., Spaggiari, L., Thomas, P. A., Rendina, E., Venuta, F., Anile, M., Schützner, J., and Rocco, G.

35. The IASLC/ITMIG thymic epithelial tumors staging project: Proposals for the T component for the forthcoming (8th) edition of the TNM classification of malignant tumors

Author

Nicholson, A. G., Detterbeck, F. C., Marino, M., Kim, J., Stratton, K., Giroux, D., Asamura, H., Crowley, J., Falkson, C., Filosso, P. L., Giaccone, G., Huang, J., Kondo, K., Lucchi, M., Marom, E. M., Okumura, M., Ruffini, E., Schil, P., Goldstraw, P., Rami-Porta, R., Ball, D., Beer, D., Beyruti, R., Bolejack, V., Chansky, K., Eberhardt, W. E. E., Edwards, J., Galateau-Sallé, F., Gleeson, F., Groome, P., Kennedy, C., Kingsbury, L., Kim, Y. T., Kondo, H., Krasnik, M., Kubota, K., Lerut, A., Lyons, G., Meerbeeck, J., Mitchell, A., Nakano, T., Nowak, A., Peake, M., Rice, T., Rosenzweig, K., Rusch, V., Saijo, N., Sculier, J. -P, Shemanski, L., Suzuki, K., Tachimori, Y., Thomas, C. F., William Travis, Tsao, M. S., Turrisi, A., Vansteenkiste, J., Watanabe, H., Wu, Y. -L, Baas, P., Erasmus, J., Hasegawa, S., Inai, K., Kernstine, K., Kindler, H., Krug, L., Nackaerts, K., Pass, H., Rice, D., Blackstone, E., Call Caja, S., Ahmad, U., Detterbeck, F., Girard, N., Haam, S. J., Gomez, D. R., Bae, M. K., Ströbel, P., Marx, A., Saita, S., Wakelee, H., Bertolaccini, L., Vallieres, E., Scott, W., Su, S., Park, B., Marks, J., Khella, S., Shen, R., Rosenberg, M., Tomulescu, V., Foroulis, C., Lang-Lazdunski, L., Billè, A., Maessen, J. G., Keijzers, M., Veer, H., Wright, C., Facciolo, F., Palmieri, G., Buonerba, C., Ferguson, M., Marulli, G., Loehrer, P., Kalkat, M., Rohrberg, K., Daugaard, G., Toker, A., Erus, S., Kimmich, M., Brunelli, A., Refai, M., Nicholson, A., Lim, E., Park, I. K., Wagner, J., Tieu, B., Fang, W., Zhang, J., Yu, Z., Han, Y., Li, Y., Chen, K., Chen, G., Nagai, K., Fujii, Y., Nakajima, J., Ikeda, N., Haraguchi, S., Onuki, T., Yoshino, I., Tsuchida, M., Takahashi, S., Yokoi, K., Hanyuda, M., Niwa, H., Date, H., Maniwa, Y., Miyoshi, S., Iwasaki, A., Okamoto, T., Nagayasu, T., Tanaka, F., Suzuki, M., Yoshida, K., Okuma, Y., Horio, H., Matsumura, A., Higashiyama, M., Suehisa, H., Sano, Y., Al Kattan, K., Cerfolio, R., Gebitekin, C., Gomez Antonio, D., Kernstine, K. H., Altorki, N., Novoa, N., Scarci, M., Voltolini, L., Weder, W., Zurek, W., Arame, A., Casadio, C., Carbognani, P., Donati, G., Keshavjee, S., Klepetko, W., Moser, B., Lequaglie, C., Liberman, M., Mancuso, M., Nosotti, M., Spaggiari, L., Thomas, P. A., Rendina, E., Venuta, F., Anile, M., Schützner, J., and Rocco, G.

36. The IASLC/ITMIG thymic epithelial tumors staging project: Proposals for the T component for the forthcoming (8th) edition of the TNM classification of malignant tumors

Author

Nicholson, A. G., Detterbeck, F. C., Marino, M., Kim, J., Stratton, K., Giroux, D., Asamura, H., Crowley, J., Falkson, C., Filosso, P. L., Giaccone, G., Huang, J., Kondo, K., Lucchi, M., Marom, E. M., Okumura, M., Ruffini, E., Schil, P., Goldstraw, P., Rami-Porta, R., Ball, D., Beer, D., Beyruti, R., Bolejack, V., Chansky, K., Eberhardt, W. E. E., Edwards, J., Galateau-Sallé, F., Gleeson, F., Groome, P., Kennedy, C., Kingsbury, L., Kim, Y. T., Kondo, H., Krasnik, M., Kubota, K., Lerut, A., Lyons, G., Meerbeeck, J., Mitchell, A., Nakano, T., Nowak, A., Peake, M., Rice, T., Rosenzweig, K., Rusch, V., Saijo, N., Sculier, J. -P, Shemanski, L., Suzuki, K., Tachimori, Y., Thomas, C. F., Travis, W., Tsao, M. S., Turrisi, A., Vansteenkiste, J., Watanabe, H., Wu, Y. -L, Baas, P., Erasmus, J., Hasegawa, S., Inai, K., Kernstine, K., Kindler, H., Krug, L., Nackaerts, K., Pass, H., Rice, D., Blackstone, E., Call Caja, S., Ahmad, U., Detterbeck, F., Girard, N., Haam, S. J., Gomez, D. R., Bae, M. K., Ströbel, P., Marx, A., Saita, S., Wakelee, H., Bertolaccini, L., Vallieres, E., Scott, W., Su, S., Park, B., Marks, J., Khella, S., Shen, R., Rosenberg, M., Tomulescu, V., Foroulis, C., Lang-Lazdunski, L., Billè, A., Maessen, J. G., Keijzers, M., Veer, H., Wright, C., Facciolo, F., Palmieri, G., Buonerba, C., Ferguson, M., Marulli, G., Loehrer, P., Kalkat, M., Rohrberg, K., Daugaard, G., Toker, A., Erus, S., Kimmich, M., Brunelli, A., Refai, M., Nicholson, A., Lim, E., Park, I. K., Wagner, J., Tieu, B., Fang, W., Zhang, J., Yu, Z., Han, Y., Li, Y., Chen, K., Chen, G., Nagai, K., Fujii, Y., Nakajima, J., Ikeda, N., Haraguchi, S., Onuki, T., Yoshino, I., Tsuchida, M., Takahashi, S., Yokoi, K., Hanyuda, M., Niwa, H., Date, H., Maniwa, Y., Miyoshi, S., Iwasaki, A., Okamoto, T., Nagayasu, T., Tanaka, F., Suzuki, M., Yoshida, K., Okuma, Y., Horio, H., Matsumura, A., Higashiyama, M., Suehisa, H., Sano, Y., Al Kattan, K., Cerfolio, R., Gebitekin, C., Gomez Antonio, D., Kernstine, K. H., Altorki, N., Novoa, N., Scarci, M., Voltolini, L., Weder, W., Zurek, W., Arame, A., Casadio, C., Carbognani, P., Donati, G., Keshavjee, S., Klepetko, W., Moser, B., Lequaglie, C., Liberman, M., Mancuso, M., Nosotti, M., Spaggiari, L., Thomas, P. A., Rendina, E., Federico Venuta, Anile, M., Schützner, J., and Rocco, G.

38. The IASLC/ITMIG thymic epithelial tumors staging project: Proposal for an evidence-based stage classification system for the forthcoming (8th) edition of the TNM classification of malignant tumors

Author

Detterbeck, F. C., Stratton, K., Giroux, D., Asamura, H., Crowley, J., Falkson, C., Filosso, P. L., Frazier, A. A., Giaccone, G., Huang, J., Kim, J., Kondo, K., Lucchi, M., Marino, M., Marom, E. M., Nicholson, A. G., Okumura, M., Ruffini, E., Schil, P., Goldstraw, P., Rami-Porta, R., Ball, D., Beer, D., Beyruti, R., Bolejack, V., Chansky, K., Eberhardt, W. E. E., Edwards, J., Galateau-Sallé, F., Gleeson, F., Groome, P., Kennedy, C., Kingsbury, L., Kim, Y. T., Kondo, H., Krasnik, M., Kubota, K., Lerut, A., Lyons, G., Meerbeeck, J., Mitchell, A., Nakano, T., Anna Nowak, Peake, M., Rice, T., Rosenzweig, K., Rusch, V., Saijo, N., Sculier, J. -P, Shemanski, L., Suzuki, K., Tachimori, Y., Thomas, C. F., Travis, W., Tsao, M. S., Turrisi, A., Vansteenkiste, J., Watanabe, H., Wu, Y. -L, Baas, P., Erasmus, J., Hasegawa, S., Inai, K., Kernstine, K., Kindler, H., Krug, L., Nackaerts, K., Pass, H., Rice, D., Blackstone, E., Call Caja, S., Ahmad, U., Detterbeck, F., Girard, N., Haam, S. J., Gomez, D. R., Bae, M. K., Ströbel, P., Marx, A., Saita, S., Wakelee, H., Bertolaccini, L., Vallieres, E., Scott, W., Su, S., Park, B., Marks, J., Khella, S., Shen, R., Rosenberg, M., Tomulescu, V., Foroulis, C., Lang-Lazdunski, L., Billè, A., Maessen, J. G., Keijzers, M., Veer, H., Wright, C., Facciolo, F., Palmieri, G., Buonerba, C., Ferguson, M., Marulli, G., Loehrer, P., Kalkat, M., Rohrberg, K., Daugaard, G., Toker, A., Erus, S., Kimmich, M., Brunelli, A., Refai, M., Nicholson, A., Lim, E., Park, I. K., Wagner, J., Tieu, B., Fang, W., Zhang, J., Yu, Z., Han, Y., Li, Y., Chen, K., Chen, G., Nagai, K., Fujii, Y., Nakajima, J., Ikeda, N., Haraguchi, S., Onuki, T., Yoshino, I., Tsuchida, M., Takahashi, S., Yokoi, K., Hanyuda, M., Niwa, H., Date, H., Maniwa, Y., Miyoshi, S., Iwasaki, A., Okamoto, T., Nagayasu, T., Tanaka, F., Suzuki, M., Yoshida, K., Okuma, Y., Horio, H., Matsumura, A., Higashiyama, M., Suehisa, H., Sano, Y., Al Kattan, K., Cerfolio, R., Gebitekin, C., Gomez Antonio, D., Kernstine, K. H., Altorki, N., Novoa, N., Scarci, M., Voltolini, L., Weder, W., Zurek, W., Arame, A., Casadio, C., Carbognani, P., Donati, G., Keshavjee, S., Klepetko, W., Moser, B., Lequaglie, C., Liberman, M., Mancuso, M., Nosotti, M., Spaggiari, L., Thomas, P. A., Rendina, E., Venuta, F., Anile, M., Schützner, J., and Rocco, G.

39. The IASLC/ITMIG thymic epithelial tumors staging project: Proposal for an evidence-based stage classification system for the forthcoming (8th) edition of the TNM classification of malignant tumors

Author

Detterbeck, F. C., Stratton, K., Giroux, D., Asamura, H., Crowley, J., Falkson, C., Filosso, P. L., Frazier, A. A., Giaccone, G., Huang, J., Kim, J., Kondo, K., Lucchi, M., Marino, M., Marom, E. M., Nicholson, A. G., Okumura, M., Ruffini, E., Schil, P., Goldstraw, P., Rami-Porta, R., Ball, D., Beer, D., Beyruti, R., Bolejack, V., Chansky, K., Eberhardt, W. E. E., Edwards, J., Galateau-Sallé, F., Gleeson, F., Groome, P., Kennedy, C., Kingsbury, L., Kim, Y. T., Kondo, H., Krasnik, M., Kubota, K., Lerut, A., Lyons, G., Meerbeeck, J., Mitchell, A., Nakano, T., Nowak, A., Peake, M., Rice, T., Rosenzweig, K., Rusch, V., Saijo, N., Sculier, J. -P, Shemanski, L., Suzuki, K., Tachimori, Y., Thomas, C. F., Travis, W., Tsao, M. S., Turrisi, A., Vansteenkiste, J., Watanabe, H., Wu, Y. -L, Baas, P., Erasmus, J., Hasegawa, S., Inai, K., Kernstine, K., Kindler, H., Krug, L., Nackaerts, K., Pass, H., Rice, D., Blackstone, E., Call Caja, S., Ahmad, U., Detterbeck, F., Girard, N., Haam, S. J., Gomez, D. R., Bae, M. K., Ströbel, P., Marx, A., Saita, S., Wakelee, H., Bertolaccini, L., Vallieres, E., Scott, W., Su, S., Park, B., Marks, J., Khella, S., Shen, R., Rosenberg, M., Tomulescu, V., Foroulis, C., Lang-Lazdunski, L., Billè, A., Maessen, J. G., Keijzers, M., Veer, H., Wright, C., Facciolo, F., Palmieri, G., Buonerba, C., Ferguson, M., Marulli, G., Loehrer, P., Kalkat, M., Rohrberg, K., Daugaard, G., Toker, A., Erus, S., Kimmich, M., Brunelli, A., Refai, M., Nicholson, A., Lim, E., Park, I. K., Wagner, J., Tieu, B., Fang, W., Zhang, J., Yu, Z., Han, Y., Li, Y., Chen, K., Chen, G., Nagai, K., Fujii, Y., Nakajima, J., Ikeda, N., Haraguchi, S., Onuki, T., Yoshino, I., Tsuchida, M., Takahashi, S., Yokoi, K., Hanyuda, M., Niwa, H., Date, H., Maniwa, Y., Miyoshi, S., Iwasaki, A., Okamoto, T., Nagayasu, T., Tanaka, F., Suzuki, M., Yoshida, K., Okuma, Y., Horio, H., Matsumura, A., Higashiyama, M., Suehisa, H., Sano, Y., Al Kattan, K., Cerfolio, R., Gebitekin, C., Gomez Antonio, D., Kernstine, K. H., Altorki, N., Novoa, N., Scarci, M., Voltolini, L., Weder, W., Zurek, W., Arame, A., Casadio, C., Carbognani, P., Donati, G., Keshavjee, S., Klepetko, W., Moser, B., Lequaglie, C., Liberman, M., Mancuso, M., Nosotti, M., Spaggiari, L., Thomas, P. A., Rendina, E., Federico Venuta, Anile, M., Schützner, J., and Rocco, G.

40. Use of a sealant to prevent prolonged air leaks after lung resection: a prospective randomized study

Author

Lequaglie Cosimo, Giudice Gabriella, Marasco Rita, Morte Aniello, and Gallo Massimiliano

Subjects
Air leak, Surgical sealant, Digital chest drain, Surgery, RD1-811, Anesthesiology, RD78.3-87.3
Abstract

Abstract Background Pulmonary air leaks are common complications of lung resection and result in prolonged hospital stays and increased costs. The purpose of this study was to investigate whether, compared with standard care, the use of a synthetic polyethylene glycol matrix (CoSeal®) could reduce air leaks detected by means of a digital chest drain system (DigiVent™), in patients undergoing lung resection (sutures and/or staples alone). Methods Patients who intraoperatively showed moderate or severe air leaks (evaluated by water submersion tests) were intraoperatively randomized to receive just sutures/staples (control group) or sutures/staples plus CoSeal® (sealant group). Differences among the groups in terms of air leaks, prolonged air leaks, time to chest tube removal, length of hospital stay and related costs were assessed. Results In total, 216 lung resection patients completed the study. Nineteen patients (18.1%) in the control group and 12 (10.8%) patients in the sealant group experienced postoperative air leaks, while a prolonged air leak was recorded in 11.4% (n = 12) of patients in the control group and 2.7% (n = 3) of patients in the sealant group. The difference in the incidence of air leaks and prolonged air leaks between the two groups was statistically significant (p = 0.0002 and p = 0.0013). The mean length of hospital stay was significantly shorter in the sealant group (4 days) than the control group (8 days) (p = 0.0001). We also observed lower costs in the sealant group than the control group. Conclusion The use of CoSeal® may decrease the occurrence and severity of postoperative air leaks after lung resection and is associated with shorter hospital stay. Trial registration Not registered. The trial was approved by the Institutional Review Board of the IRCCS-CROB Basilicata Regional Cancer Institute, Rionero in Vulture, Italy.

Published
2012
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41. Liposomal amphotericin B (AmBisome): efficacy and safety of low-dose therapy in pulmonary fungal infections

Author

Lequaglie, C.

Abstract

A prospective study of the treatment of fungal infections with low-dose AmBisome enrolled 36 of 52 patients with thoracic malignancies who developed pulmonary fungal infections in the National Cancer Centre, Milan, over a 3.5 year period. Thirty-three high-risk patients had received standard prophylaxis with iv fluconazole. In these patients, symptoms indicating deep mycosis were detected after 7-9 days of primary prophylactic therapy. Another three patients, not treated with fluconazole, showed similar symptoms. Bronchoalveolar lavage, blood culture and/or CT scan of chest diagnosed invasive aspergillosis in 29 patients and deep invasive Candida infection in seven. AmBisome was given at 1-2.2 mg/kg/day iv for 10 days to avoid or decrease toxicity normally induced by amphotericin B. The fungal infection was eradicated in all 36 patients. Negative cultures were obtained after 5 or 6 days of antifungal treatment. No adverse reactions attributed to AmBisome were detected. After a follow up of 5-48 months, 30 patients were still alive. Six patients had died, two due to adult respiratory distress syndrome and four due to progression of cancer. No mycotic relapses or reinfections were detected during follow up. In a subset of critically ill patients with thoracic malignancies, the administration of low-dose liposomal amphotericin B (AmBisome) resulted in complete eradication of pulmonary Aspergillus and Candida infections, and was remarkably well tolerated.

Published
2002

43. Comments on 'Preventive home therapy for symptomatic patients affected by COVID-19 and followed by teleconsultations' by D'Amato et al

Author

Francesco De Blasio, Fabio Numis, Antonio Sacchetta, Francesco Stefanelli, Mario Spatafora, Franco D'Adduzio, Stefano Baglioni, Fausto Ferraro, Potena A, Mario Cazzola, Stefano Picciolo, Carlo Zottola, Francesco Romano, Cosimo Lequaglie, Roberto Fumagalli, Renato Cutrera, Pierluigi Bracciale, Enrico Clini, Germano Bettoncelli, Eugenio Sabato, Paolo Palange, Girolamo Adiletta, Maria Gabriella Matera, Adiletta, G., Baglioni, S., Bettoncelli, G., Bracciale, P., Cazzola, M., Clini, E. M., Cutrera, R., D'Adduzio, F., de Blasio, F., Ferraro, F., Fumagalli, R., Lequaglie, C., Matera, M. G., Numis, F., Palange, P., Picciolo, S., Potena, A., Romano, F., Sabato, E., Sacchetta, A., Spatafora, M., Stefanelli, F., and Zottola, C.

Subjects
Pulmonary and Respiratory Medicine, Pediatrics, medicine.medical_specialty, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), business.industry, Home therapy, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID-19, 030204 cardiovascular system & hematology, LMWH, 03 medical and health sciences, 0302 clinical medicine, medicine, Steroids, business, Letter to the Editor, 030215 immunology
Abstract

We have read with interest the letter from D’Amato et al. entitled “Preventive home therapy for symptomatic patients affected by COVID-19 and followed by teleconsultations”....

Published
2021

44. What can platinum offer yet in the treatment of PS2 NSCLC patients? A systematic review and meta-analysis

Author

Cosimo Lequaglie, Antonio Russo, Eugenio Fiorentino, Daniele Santini, Patrick Pauwels, Massimo Cajozzo, Francesco Passiglia, Sergio Rizzo, Giuseppe Bronte, Ignacio Gil-Bazo, Christian Rolfo, Jan P. van Meerbeeck, Bronte, G., Rolfo, C., Passiglia, F., Rizzo, S., Gil-Bazo, I., Fiorentino, E., Cajozzo, M., Van Meerbeeck, J., Lequaglie, C., Santini, D., Pauwels, P., and Russo, A

Subjects
Oncology, medicine.medical_specialty, Lung Neoplasms, Phase iii trials, Settore MED/06 - Oncologia Medica, medicine.medical_treatment, Population, Settore MED/21 - Chirurgia Toracica, NSCLC, law.invention, Single agent, Overall response rate, Randomized controlled trial, Performance statu, Chemotherapy, Performance status, Platinum, Doublet, law, Carcinoma, Non-Small-Cell Lung, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Intensive care medicine, education, Randomized Controlled Trials as Topic, education.field_of_study, business.industry, Hematology, Survival Rate, Meta-analysis, Non small cell, Human medicine, business
Abstract

Background: Randomized phase III trials showed interesting, but conflicting results, regarding the treatment of NSCLC, PS2 population. This meta-analysis aims to review all randomized trials comparing platinum-based doublets and single-agents in NSCLC PS2 patients. Materials and methods: Data from all published randomized trials, comparing efficacy and safety of platinum-based doublets to single agents in untreated NSCLC, PS2 patients, were collected. Pooled ORs were calculated for the 1-year Survival-Rate (ly-SR), Overall Response Rate (ORR), and grade 3-4 (G3-4) hematologic toxicities. Results: Six eligible trials (741 patients) were selected. Pooled analysis showed a significant improvement in ORR (OR: 3.243; 95% CI: 1.883-5.583) and ly-SR (OR: 1.743; 95% CI: 1.203-2.525) in favor of platinum-based doublets. 03-4 hematological toxicities were also more frequent in this group. Conclusion: This meta-analysis suggests that platinum-combination regimens are superior to singleagent both in terms of ORR and survival-rate with increase of severe hematological toxicities. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

Published
2015

46. What can platinum offer yet in the treatment of PS2 NSCLC patients? A systematic review and meta-analysis.

Author

Bronte G, Rolfo C, Passiglia F, Rizzo S, Gil-Bazo I, Fiorentino E, Cajozzo M, Van Meerbeeck JP, Lequaglie C, Santini D, Pauwels P, and Russo A

Subjects
Carcinoma, Non-Small-Cell Lung mortality, Humans, Lung Neoplasms mortality, Randomized Controlled Trials as Topic, Survival Rate, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Carcinoma, Non-Small-Cell Lung drug therapy, Lung Neoplasms drug therapy, Platinum administration & dosage
Abstract

Background: Randomized phase III trials showed interesting, but conflicting results, regarding the treatment of NSCLC, PS2 population. This meta-analysis aims to review all randomized trials comparing platinum-based doublets and single-agents in NSCLC PS2 patients., Materials and Methods: Data from all published randomized trials, comparing efficacy and safety of platinum-based doublets to single agents in untreated NSCLC, PS2 patients, were collected. Pooled ORs were calculated for the 1-year Survival-Rate (1y-SR), Overall Response Rate (ORR), and grade 3-4 (G3-4) hematologic toxicities., Results: Six eligible trials (741 patients) were selected. Pooled analysis showed a significant improvement in ORR (OR: 3.243; 95% CI: 1.883-5.583) and 1y-SR (OR: 1.743; 95% CI: 1.203-2.525) in favor of platinum-based doublets. G3-4 hematological toxicities were also more frequent in this group., Conclusion: This meta-analysis suggests that platinum-combination regimens are superior to singleagent both in terms of ORR and survival-rate with increase of severe hematological toxicities., (Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)

Published
2015
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47. How to distinguish an active air leak from a pleural space effect.

Author

Marasco RD, Giudice G, and Lequaglie C

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Drainage, Female, Humans, Male, Middle Aged, Prospective Studies, Young Adult, Air, Pleural Cavity, Postoperative Complications diagnosis, Thoracic Surgical Procedures
Abstract

Aim: We aimed to distinguish a pleural space effect from an active air leak, using a digital chest drain system that provided continuous air flow and pleural pressure checks., Methods: between March 2010 and October 2011, we employed 144 digital drains for 138 thoracic surgical procedures., Results: We observed 18 (12.5%) active air leaks, among which 4 (2.8%) were prolonged air leaks characterized by high differential pleural pressure due to increased mean expiratory pressure (>1 cm H(2)O; p<0.0001), and 3 (2.1%) late air leaks, all long-lasting (p<0.0001), predicted by pressure curve divergence before the air flow appearance. We also reported 25 (17.4%) pleural space effects characterized by a high differential pleural pressure, but mainly due to a lower mean inspiratory pressure (<20 cm H(2)O; p<0.0001), and especially related to surgical pleurodesis procedures (p<0.0003) and wide lung resections (p<0.0002); there was no increasing pneumothorax after provocative clamping., Conclusions: A digital chest drain system, ensuring continuous air flow and pleural pressure measurement, could clearly identify a pleural space effect, avoiding the frequent misinterpretation of an active air leak, and allowing safe removal of the chest tube at the right time.

Published
2012
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48. [Solitary metachronous metastasis of the sternum from pancreatic adenocarcinoma].

Author

Lequaglie C, Della Morte A, Feudale E, and Giudice G

Subjects
Adenocarcinoma drug therapy, Adenocarcinoma pathology, Adenocarcinoma radiotherapy, Adenocarcinoma surgery, Aged, Bone Neoplasms diagnosis, Bone Neoplasms diagnostic imaging, Bone Neoplasms pathology, Chemotherapy, Adjuvant, Humans, Lymph Node Excision, Magnetic Resonance Imaging, Male, Palliative Care, Pancreaticoduodenectomy, Positron-Emission Tomography, Prognosis, Radiotherapy, Adjuvant, Surgical Mesh, Tomography, X-Ray Computed, Adenocarcinoma secondary, Bone Neoplasms secondary, Bone Neoplasms surgery, Pancreatic Neoplasms drug therapy, Pancreatic Neoplasms radiotherapy, Pancreatic Neoplasms surgery, Sternum surgery
Abstract

Sternal metastases from adenocarcinoma of the pancreas are extremely rare, and even more so when solitary. Two years earlier, the patient reported on here, a 67-year-old man with a solitary osteolytic lesion of the sternal manubrium, had undergone a duodeno-cephalopancreatectomy for adenocarcinoma of the pancreas (G2, pY3, pN1) followed by adjuvant radio-chemotherapy. PET/CT scans, in response to the onset of burning pain in the sternal region, revealed a hypermetabolic area only at the level of the manubrium, while MRI showed a bulging manubrium due to the presence of extensive solid pathological tissue towards the right articulations of the ribs. Abnormal tumour markers were: CEA = 12, n.v. 0-4; Ca 15-3 = 512, n.v. 0-51, Ca 19-9 = 8777, n.v. 0-18. A partial sternectomy was performed with en-bloc resection of the hemiclavicles and the anterior tract of the 1st and 2nd ribs bilaterally with a mediastinic lymphadenectomy and repair with a sandwich prosthesis of prolene mesh and methacrylate, protecting the supra-aortic trunks and the anonymous vein with a polytetrafluoroethylene patch. The histological examination revealed secondary adenocarcinoma with 3 mediastinal metastatic lymph nodes. In view of the severe prognosis, a resection with palliative intent was also performed, which, when carried out in specialised centres, presents no contraindications in terms of cost-benefits.

Published
2007

49. [Iatrogenic hemothorax and unknown spontaneous rupture of the oesophagus, double dramatic disease].

Author

Lequaglie C, Brega Massone PP, and Giudice G

Subjects
Aged, Diagnosis, Differential, Humans, Male, Prognosis, Radiography, Thoracic, Rupture, Spontaneous, Esophageal Perforation complications, Esophageal Perforation diagnosis, Esophageal Perforation surgery, Hemothorax complications, Hemothorax diagnosis, Hemothorax surgery
Abstract

Iatrogenic haemothorax is a dramatic event and generally lethal if not treated appropriately and rapidly. Any thoracic co-morbidity increases the risk of death. Spontaneous rupture of the oesophagus is an equally lethal illness if not treated. We report a case of left haemothorax after a thoracic drain for spontaneous pneumothorax with ipsilateral effusion in a 77-year old male. The patient was operated on 6 hours after admission to hospital. We found a laceration of the left common carotid and an unsuspected rupture of the supradiaphragmatic oesophagus. Repair of the lesions in a single session led to no further complications. The patient was discharged in good condition. We know of only one case in the literature with Boerhaave's syndrome not treated surgically, whereas all the other cases had a negative outcome if surgery was not performed promptly. The non-specific symptoms in our case delayed the correct diagnosis of the spontaneous rupture of the oesophagus. The mortality rate is 31% in the literature even when there is an early diagnosis with well performed surgical reapair. A rapid decision as to the best surgical tactics and sending these patients to referral centres specialising in oesophageal disease are the keys to achieving good results.

Published
2004

50. A new proposal of skin-closure system for median sternotomy: usefulness and cosmetic results analysis of MEDIZIP Surgical Zipper in neoplastic immuno-compromised patients.

Author

Brega-Massone PP, Lequaglie C, Magnani B, and Cataldo I

Subjects
Adult, Child, Humans, Length of Stay, Surgical Instruments standards, Suture Techniques, Wound Healing, Cosmetic Techniques instrumentation, Dermatologic Surgical Procedures, Plastic Surgery Procedures methods, Sternum surgery
Abstract

Background and Objectives: The authors evaluate the effectiveness and the cosmetic results obtained using the new skin closing system MEDIZIP Surgical Zipper in oncological immuno-compromised patients submitted to median sternotomy., Methods: In our Institute, from 1999 to 2002, MEDIZIP was used to close the sternal wounds in 45 patients undergoing median sternotomy for bilateral metastasectomy, It took about half a minute (mean time: 32.00 +/- 11.48 sec) to perform the application. To evaluate the cosmetic results, a three-level scale was conceived: level 1: very good, level 2: satisfactory, level 3: inadequate., Results: Overall forty-two 20 cm-long zippers were used, two 25 cm-long and one 30 cm-long. MEDIZIP remained in situ for an average of 9.98 +/- 2.23 days (median: 9 days; range: 8-13 days). The average time taken for inspection was 70.00 +/- 2.48 sec (median: 70, range: 45-130) and the zipper was removed in a few seconds. No wound infections were observed. We classified 39 patients at level 1 (very good, 87%), and 6 at level 2 (satisfactory, 13%)., Conclusions: MEDIZIP can be considered an effective skin-closure system which is easily and quickly handled and assures good cosmetic results with non-invasive removal; it proves particularly useful in pediatric patients and in adults affected by neoplastic diseases and undergoing multiple combined anti-cancer treatments.

Published
2003
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