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What can platinum offer yet in the treatment of PS2 NSCLC patients? A systematic review and meta-analysis.
- Source :
-
Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2015 Sep; Vol. 95 (3), pp. 306-17. Date of Electronic Publication: 2015 Apr 11. - Publication Year :
- 2015
-
Abstract
- Background: Randomized phase III trials showed interesting, but conflicting results, regarding the treatment of NSCLC, PS2 population. This meta-analysis aims to review all randomized trials comparing platinum-based doublets and single-agents in NSCLC PS2 patients.<br />Materials and Methods: Data from all published randomized trials, comparing efficacy and safety of platinum-based doublets to single agents in untreated NSCLC, PS2 patients, were collected. Pooled ORs were calculated for the 1-year Survival-Rate (1y-SR), Overall Response Rate (ORR), and grade 3-4 (G3-4) hematologic toxicities.<br />Results: Six eligible trials (741 patients) were selected. Pooled analysis showed a significant improvement in ORR (OR: 3.243; 95% CI: 1.883-5.583) and 1y-SR (OR: 1.743; 95% CI: 1.203-2.525) in favor of platinum-based doublets. G3-4 hematological toxicities were also more frequent in this group.<br />Conclusion: This meta-analysis suggests that platinum-combination regimens are superior to singleagent both in terms of ORR and survival-rate with increase of severe hematological toxicities.<br /> (Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Carcinoma, Non-Small-Cell Lung mortality
Humans
Lung Neoplasms mortality
Randomized Controlled Trials as Topic
Survival Rate
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Carcinoma, Non-Small-Cell Lung drug therapy
Lung Neoplasms drug therapy
Platinum administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0461
- Volume :
- 95
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Critical reviews in oncology/hematology
- Publication Type :
- Academic Journal
- Accession number :
- 25922216
- Full Text :
- https://doi.org/10.1016/j.critrevonc.2015.03.010