1. A mini-review on Biginelli adducts with notable pharmacological properties
- Author
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Ângelo de Fátima, Taniris C. Braga, Leonardo da S. Neto, Bruna S. Terra, Breno G.F. Oliveira, Daniel L. da Silva, and Luzia V. Modolo
- Subjects
Biginelli adducts ,Antiproliferative activity cancer ,Calcium channel ,Antimicrobial activity ,Antioxidants ,Medicine (General) ,R5-920 ,Science (General) ,Q1-390 - Abstract
Since the disclosure of Biginelli reaction by the chemist Pietro Biginelli, functionalized 3,4-dihydropyrimidin-2(1H)-ones/thiones (DHPMs) have emerged as prototypes for the design of compounds with a broad variety of biological activities. This mini-review describes over 100 Biginelli adducts demonstrated to be promising anticancer, inhibitors of calcium channel, anti-inflammatory, antimicrobial and antioxidant agents. Thus, this compilation presents the most notable in vitro and in vivo results for such fascinating class of organic compounds.
- Published
- 2015
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