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A mini-review on Biginelli adducts with notable pharmacological properties
- Source :
- Journal of Advanced Research, Vol 6, Iss 3, Pp 363-373 (2015)
- Publication Year :
- 2015
- Publisher :
- Elsevier, 2015.
-
Abstract
- Since the disclosure of Biginelli reaction by the chemist Pietro Biginelli, functionalized 3,4-dihydropyrimidin-2(1H)-ones/thiones (DHPMs) have emerged as prototypes for the design of compounds with a broad variety of biological activities. This mini-review describes over 100 Biginelli adducts demonstrated to be promising anticancer, inhibitors of calcium channel, anti-inflammatory, antimicrobial and antioxidant agents. Thus, this compilation presents the most notable in vitro and in vivo results for such fascinating class of organic compounds.
Details
- Language :
- English
- ISSN :
- 20901232 and 20901224
- Volume :
- 6
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Advanced Research
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f6b790c9e5454458a7c5a2c1e5a84742
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.jare.2014.10.006