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1. The human orphan nuclear receptor tailless (TLX, NR2E1) is druggable

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3. Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase.

4. Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site.

5. Discovery of 6-[(3 S ,4 S )-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor.

6. Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme.

7. GRB2 enforces homology-directed repair initiation by MRE11.

9. An enolase inhibitor for the targeted treatment of ENO1-deleted cancers.

10. Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties.

11. Discovery of IACS-9439, a Potent, Exquisitely Selective, and Orally Bioavailable Inhibitor of CSF1R.

12. Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffold Hopping, Optimization, and Pharmacological Evaluation.

13. The 3 S Enantiomer Drives Enolase Inhibitory Activity in SF2312 and Its Analogues.

14. Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies.

15. The N-Terminal Domain of ALS-Linked TDP-43 Assembles without Misfolding.

16. SF2312 is a natural phosphonate inhibitor of enolase.

17. An Adaptive Mutation in Enterococcus faecium LiaR Associated with Antimicrobial Peptide Resistance Mimics Phosphorylation and Stabilizes LiaR in an Activated State.

19. Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors.

20. Potent and selective inhibition of SH3 domains with dirhodium metalloinhibitors.

21. A variable DNA recognition site organization establishes the LiaR-mediated cell envelope stress response of enterococci to daptomycin.

22. Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2.

23. The human orphan nuclear receptor tailless (TLX, NR2E1) is druggable.

24. (19)F NMR reveals multiple conformations at the dimer interface of the nonstructural protein 1 effector domain from influenza A virus.

25. FAK dimerization controls its kinase-dependent functions at focal adhesions.

26. Competition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion.

27. Phosphorylation-dependent conformational changes and domain rearrangements in Staphylococcus aureus VraR activation.

28. Identification of a hydrophobic cleft in the LytTR domain of AgrA as a locus for small molecule interactions that inhibit DNA binding.

29. Human cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) is dimeric in its disulfide-reduced state, with natively disordered N-terminal region.

30. Structural basis for the sequence-specific recognition of human ISG15 by the NS1 protein of influenza B virus.

31. H-NS forms a superhelical protein scaffold for DNA condensation.

32. The absence of inorganic salt is required for the crystallization of the complete oligomerization domain of Salmonella typhimurium histone-like nucleoid-structuring protein.

33. Investigation of the self-association and hetero-association interactions of H-NS and StpA from Enterobacteria.

34. StpA protein from Escherichia coli condenses supercoiled DNA in preference to linear DNA and protects it from digestion by DNase I and EcoKI.