1. Clinical practice recommendations for growth hormone treatment in children with chronic kidney disease
- Author
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Drube, Jens, Wan, Mandy, Bonthuis, Marjolein, Wuhl, Elke, Bacchetta, Justine, Santos, Fernando, Grenda, Ryszard, Edefonti, Alberto, Harambat, Jerome, Shroff, Rukshana, Tonshoff, Burkhard, Haffner, Dieter, Schnabel, D, Linglart, A, Rees, L, Cochat, P, Brauner, C, Renault, D, Romano, LN, Colling, G, Prytula, A, Leifheit-Nestler, M, Klaus, G, Schmitt, CP, Stabouli, S, Reusz, G, Verrina, E, Groothoff, J, Anton-Gamero, M, Petrosyan, E, Bakkaloglu, SA, Dursun, I, Booth, C, Aufricht, C, Vande Walle, J, Vondrak, K, Holtta, T, Ranchin, B, Fischbach, M, Stefanidis, C, Kyriakou, A, Printza, N, Paglialonga, F, Vidal, E, Allinovi, M, Jankauskiene, A, Zurowska, A, Faria, M Do Sameiro, Ariceta, G, Sartz, L, Bakkaloglu, S, Bayazit, AK, Duzova, A, Knops, N, Raees, A, Zieg, J, Pape, L, Melk, A, Dello, L, Guzzo, I, Ghio, L, Murer, L, Peruzzi, L, Bouts, A, Cornelissen, M, Lopez-Baez, Victor, Soylemezoglu, O, Topaloglu, R, Christian, M, Marks, S, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Clinicum, HUS Children and Adolescents, Helsinki University Hospital Area, Lastentautien yksikkö, Children's Hospital, and Çukurova Üniversitesi
- Subjects
0301 basic medicine ,PREPUBERTAL CHILDREN ,Pediatrics ,medicine.medical_treatment ,030232 urology & nephrology ,Growth disorders ,[SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology ,0302 clinical medicine ,Quality of life ,QUALITY-OF-LIFE ,3123 Gynaecology and paediatrics ,Chronic kidney disease ,Child ,ADULT HEIGHT ,Human Growth Hormone ,Immunosuppression ,Urology & Nephrology ,DOUBLE-BLIND TRIAL ,3. Good health ,Growth hormone treatment ,Nephrology ,Child, Preschool ,medicine.symptom ,Life Sciences & Biomedicine ,medicine.medical_specialty ,CATCH-UP GROWTH ,Short stature ,03 medical and health sciences ,REPLACEMENT THERAPY ,Renal Dialysis ,medicine ,Humans ,Renal Insufficiency, Chronic ,SHORT STATURE ,Dialysis ,LONG-TERM GROWTH ,[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics ,Science & Technology ,Paediatric kidney disease ,PEDIATRIC-PATIENTS ,business.industry ,Consensus Statement ,Guideline ,medicine.disease ,3126 Surgery, anesthesiology, intensive care, radiology ,Kidney Transplantation ,Hormones ,Transplantation ,030104 developmental biology ,[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology ,CHRONIC-RENAL-FAILURE ,business ,Kidney disease - Abstract
Achieving normal growth is one of the most challenging problems in the management of children with chronic kidney disease (CKD). Treatment with recombinant human growth hormone (GH) promotes longitudinal growth and likely enables children with CKD and short stature to reach normal adult height. Here, members of the European Society for Paediatric Nephrology (ESPN) CKD–Mineral and Bone Disorder (MBD), Dialysis and Transplantation working groups present clinical practice recommendations for the use of GH in children with CKD on dialysis and after renal transplantation. These recommendations have been developed with input from an external advisory group of paediatric endocrinologists, paediatric nephrologists and patient representatives. We recommend that children with stage 3–5 CKD or on dialysis should be candidates for GH therapy if they have persistent growth failure, defined as a height below the third percentile for age and sex and a height velocity below the twenty-fifth percentile, once other potentially treatable risk factors for growth failure have been adequately addressed and provided the child has growth potential. In children who have received a kidney transplant and fulfil the above growth criteria, we recommend initiation of GH therapy 1 year after transplantation if spontaneous catch-up growth does not occur and steroid-free immunosuppression is not a feasible option. GH should be given at dosages of 0.045–0.05 mg/kg per day by daily subcutaneous injections until the patient has reached their final height or until renal transplantation. In addition to providing treatment recommendations, a cost-effectiveness analysis is provided that might help guide decision-making., This Evidence-Based Guideline developed by members of the European Society for Paediatric Nephrology CKD-MBD, Dialysis and Transplantation working groups presents clinical practice recommendations for the use of growth hormone in children with chronic kidney disease on dialysis and after renal transplantation.
- Published
- 2019