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BackgroundThe practice of regular physical activity can reduce the incidence of certain cancers (colon, breast, and prostate) and improve overall survival after treatment by reducing fatigue and the risk of relapse. This impact on survival has only been demonstrated in active patients with lymphoma before and after treatment. As poor general health status reduces the chances of survival and these patients are most likely to also have sarcopenia, it is important to be able to improve their physical function through adapted physical activity (APA) as part of supportive care management. Unfortunately, APA is often saved for patients with advanced blood cancer. As a result, there is a lack of data regarding the impact of standardized regular practice of APA and concomitant chemotherapy as first-line treatment on lymphoma survival. ObjectiveThis study aimed to assess the impact of a new and open rehabilitation program suitable for a frail population of patients treated for diffuse large B-cell lymphoma (DLBCL). MethodsPHARAOM (Physical Activity Program for the Survival of Elderly Patients with Lymphoma) is a phase 3 randomized (1:1) study focusing on a frail population of patients treated for DLBCL. The study will include 186 older adult patients with DLBCL (aged >65 years) receiving rituximab and chemotherapy. Overall, 50% (93/186) of patients (investigational group) will receive APA along with chemotherapy, and they will be supervised by a dedicated qualified kinesiologist. The APA program will include endurance and resistance training at moderate intensity 3 times a week during the 6 months of chemotherapy. The primary end point of this study will be event-free survival of the patients. The secondary end points will include the overall survival, progression-free survival, prevalence of sarcopenia and undernutrition, and patients’ quality of life. This study will be conducted in accordance with the principles of the Declaration of Helsinki. ResultsRecruitment, enrollment, and data collection began in February 2021, and 4 participants have been enrolled in the study as of July 2022. Data analysis will begin after the completion of data collection. Future outcomes will be published in peer-reviewed health-related research journals and presented at national congress, and state professional meetings. This publication is based on protocol version 1.1, August 3, 2020. ConclusionsThe PHARAOM study focuses on highlighting the benefits of APA intervention on survival during the period of first-line treatment of patients with DLBCL. This study could also contribute to our understanding of how an APA program can reduce complications such as sarcopenia in patients with lymphoma and improve their quality of life. By documenting the prevalence and relationship between sarcopenia and exercise load, we might be able to help physicians plan better interventions in the care of patients with DLBCL. Trial RegistrationClinicalTrials.gov NCT04670029; https://clinicaltrials.gov/ct2/show/NCT04670029 International Registered Report Identifier (IRRID)DERR1-10.2196/40969

This article describes an attempt to memorise the arbitration processes conducted during the elaboration of an urban development plan for the city of Vitré via storymaps or narrative maps used to address landscape planning issues within the framework of urban planning regulations. The project develops a method for constructing these narratives ex-post, by using records of the speeches of actors in situ, making it possible to complete the storymaps with events during or prior to the planning process. The storymaps make it possible to place the urban development plan within a more long-term geo-historical perspective of landscape planning. They suggest that the urban development plans could play a role in the memorising of perceptions of space which influence public action in a given period.

Primary CNS involvement is very rare in Hodgkin lymphoma. Here we present two cases of spinal cord dissemination. Two women of 40 and 65 years of age presented symptoms of spinal cord injury; imaging showed an intramedullary mass in T10 and T2, respectively, without vertebral involvement and upper diaphragmatic lymph nodes. Lymph-node biopsy confirmed the diagnosis of classical Hodgkin lymphoma in both patients. The first patient received four cycles of chemotherapy (escalated BEACOPP and ABVD) with intrathecal therapy, and the second four cycles of doxorubicin, vinblastine, dacarbazine (AVD) and local irradiation after surgery decompression. Complete metabolic response was obtained at the end of treatment. After 5 and 7 years of follow-up respectively, neurological deficits persisted in both.

We report observations and modeling of the stellar remnant and presumed double-degenerate merger of Type Iax supernova Pa 30, which is the probable remnant of SN 1181 AD. It is the only known bound stellar SN remnant and the only star with Wolf–Rayet features that is neither a planetary nebula central star nor a massive Population I progenitor. We model the unique emission-line spectrum with broad, strong O vi and O viii lines as a fast stellar wind and shocked, hot gas. Non-LTE wind modeling indicates a mass-loss rate of ∼10 ^−6 M _⊙ yr ^−1 and a terminal velocity of ∼15,000 km s ^−1 , consistent with earlier results. O viii lines indicate shocked gas temperatures of T ≃ 4 MK. We derive a magnetic field upper limit of B < 2.5 MG, below earlier suggestions. The luminosity indicates a remnant mass of 1.0–1.65 M _⊙ with ejecta mass 0.15 ± 0.05 M _⊙ . Archival photometry suggests the stellar remnant has dimmed by ∼0.5 mag over 100 yr. A low Ne/O < 0.15 argues against an O-Ne white dwarf in the merger. A cold dust shell is only the second detection of dust in an SN Iax and the first of cold dust. Our ejecta mass and kinetic energy estimates of the remnant are consistent with Type Iax extragalactic sources.

Presentation of the Dutch language past and present and historical comparison of the situations for Dutch and Breton.

Disorders of the long head biceps tendon are among the most challenging of shoulder problems to diagnose and manage. In this Technical Note, we introduce an arthroscopic technique for proximal biceps tenodesis high in the groove at the articular margin of the humeral head using a single anchor and 2 self-cinching loops followed by 5 alternating half-hitches to secure the construct. This method is simple and enables stable fixation of the biceps tendon.

Although Breton is today only known, actively or passively, by a diminishing group of older adults living in rural areas, it is being taught in both the private and public sectors to French-speaking children by Neo-Breton-speaking teachers under the ‘right to be different’. Breton has moved from the pragmatic sphere into the symbolic. Far removed from the vernaculars, it is descended from a language that was purified by interwar activists to respond to two objectives, namely to ‘reconquer’ a virtual linguistic terrain, including extending it to areas in which Breton had never been spoken, and to open up a cultural and commercial space for Breton identity, an objective now supported by the state, local authorities and the regional media.

We report 20 cases of extensively drug-resistant tuberculosis managed in France. Treatment was individualized and included bedaquiline and linezolid for most patients and surgery in 8 patients. At last follow-up (22 months), 19 patients had achieved conversion from positive to negative on culture testing. These promising results of comprehensive management obtained in a small series deserve confirmation.

In 1999, Micil Chonraí’s memoirs (Indreabhan, Clo Iar-Chonnacht) were published under the title Stairsheanchas Mhicil Chonraí (Micil Chonraí’s life story). The book comprised transcriptions by Conchuir O’Giollagain of the author-narrator-character’s taped autobiographical recordings. Chonraí was born in 1919 and was a member of one of forty Connemara Gaelic-speaking families that were resettled in County Meath in 1935 by the Irish government to revitalise the vernacular in this anglicised region. This ethnological, historical and social testimony allows us to compare viewpoints and to reflect on sociolinguistic practices and representations of Gaelic in the 20th century.

For the most part, Photographic Observatories of the Landscape are confronted with limiting factors when it comes to facilitating the sharing of documents, the sustainability of archiving and the reliability of metadata as well as the capacity to use it. The realisation of these limiting factors by the organisations supporting the Observatories in Brittany led us to propose a project for a platform within a research programme funded by the regional council of Brittany. This POPP-Breizh project for a platform for Photographic Observatories of the Landscape in Brittany was validated in June 2011 by the regional landscape committee and was implemented thanks to the funding of a thesis grant via a regional environmental and urban planning agency co-funding programme involving the regional council and the European Regional Development Fund for the IT development of the platform. This platform project, providing support services (putting photographic series online, indexing metadata, and circulating documents among stakeholders and the public), soon produced positive results well beyond the initial scope of the project, especially regarding two aspects : the building of a network of stakeholders and the sharing of innovations. As a result, it is also in the co-construction of the collaborative management of the programme’s implementation that POPP-Breizh has proved to be an innovative and complex project.

We present Gran Telescopio Canarias (GTC) spectroscopic confirmations of 55 faint Planetary Nebulae (PNe) candidates discovered largely in the INT Photometric H α Survey (IPHAS) of the Northern Galactic Plane by our pro-am collaboration. We confirm 46 of them as 'True' (T), 4 as 'Likely' (L), and 5 as 'Possible' (P) PNe and including 5 new PNe central star (CSPN) discoveries. This was from observations of 62 new candidates yielding a maximum PN discovery success rate of 89 per cent. The sensitivity and longer wavelength coverage of IPHAS allows PNe to be found in regions of greater extinction and at these lower Galactic latitudes, including PNe in a more advanced evolutionary state and at larger distances compared to previously known Galactic PNe. We use a holistic set of observed characteristics and optical emission-line diagnostics to confirm candidates. Plasma properties have been determined in a self-consistent way using pyneb. This work is facilitated by the functionality of our powerful, multiwavelength database 'HASH' (Hong Kong, Australian Astronomical Observatory, Strasbourg Observatory H-alpha Planetary Nebula catalogue) that federates known imaging, spectroscopy, and other pertinent data for all Galactic T, L, P PNe, and the significant numbers of mimics. Reddenings, corrected radial velocities, and PNe electron density and temperature estimates are provided for these new PNe wherever possible. [ABSTRACT FROM AUTHOR]

This article presents the origins and development of the Atlas Linguistique du Créole des Petites Antilles (ALPA) in its academic, technical/scientific, historical and sociolinguistic contexts. The first volume of the ALPA, which was published in 2011 (Paris, CTHS), was based on a questionnaire comprising 467 questions administered to 92 informants across 48 survey points. It shows the dialectological distribution of the Creole in this area and is a key tool for geolinguistic studies on the subject.

The thesis of Alan-Gwenog Berr (whose official name is Alain Le Berre, a research fellow at the CNRS) entitled Ichthyonymie bretonne was published by the UBO (1970, 1973, 1973). It is an almost exhaustive inventory of the names of marine animals on the coasts of Lower Brittany (110 survey points): it contains not only the names of fish, but also those of all living beings in the sea of the region (except for algae), including mammals and marine birds. The field research, carried out in close collaboration with researchers from the Faculty of Science, is of a high scientific standard, both from a systematic and linguistic point of view. The article retraces the history of the project, outlines its methodology and proposes future avenues for linguistic exploitation.

Since 2000, many landscape photographic observatories (Observatoire Photographique du Paysage, OPP) have spread out in France and all around Europe, either at local, regional and national levels. They tend to be better integrated into public policies throughout planning and assessment. They are also use as communication tool between people and local stakeholders through survey and participative actions. These experimentations open up new horizons for the implementation of OPP to get information about landscape dynamics as well as about social representation of landscape dynamics.

The first twelve issues of La Bretagne Linguistique reflected the study and reflection days of the Groupe de recherche sur l'économie linguistique de la Bretagne, founded in 1984. They were mainly devoted to sociolinguistics. After a long interruption, we thought it would be a good idea, before returning to sociolinguistics, to devote a special issue to Breton dialectology and geolinguistics. The organisation of this issue is under the responsibility of Jean Le Dû, Professor Emeritus, and Nelly Blanchard, who teaches dialectology in the Celtic department of the University of Western Brittany.

Diachronous photographic series are didactic resources for understanding landscape dynamics. In fact, several experiments, using quantitative and qualitative methods, attest to this interest in analysing photographs. The example of documents on urban dynamics in Brittany (France) makes it possible to study potentials of both corpus and methods. The utilization of photographic observatories of landscape (Observatoires photographiques du paysage, OPP) and of an iconographic complementary fund with a qualitative approach gives a detailed reflection of landscape dynamics. In other words, this corpus is representative of the regional dynamics from the century scale to the multiannual scale through identification of local specificities and practices in connection with the landscape.

Presentation of the colloquium "Is there a French sociolinguistic exception?" which took place in Brest on 5, 6 and 7 June 1997, followed by a letter from Renée Balibar.

Based on the distinction between language and speech, and opting for an approach to the speaker as both subject and producer of language, this article proposes to define language, speech and society in relation to each other, in other words, to address the sociality of language, the relationships between institutions and idioms, their hierarchy and reciprocity, and the distinction between the two registers of social communication.

This paper opened the “Badume-Standard-Norme” conference which took place in Brest (June 2-4, 1994). The authors of this paper explain why they decided to organise this conference: to confront the theories they have developed while studying the Breton language and its speakers, their open-air laboratory, with the criticism of researchers interested in linguistic matters. At the forefront of these theories detailed here is “badume” (ba-dum: “at home”), used to designate the Breton language spoken locally in traditional society, and then by extension to the languages which fall within the parity register. The “standard” and the “norm”, which belong to the disparity register, are linked to it. If these instruments are used to describe the reality of Breton in Western-Brittany, what about elsewhere?

The dictionaries of all the major languages with a long lexicographical tradition are generally referenced to the written language, particularly the literary language. The Breton language has a long lexicographical tradition, but the sources of its dictionaries are mixed, so that none of them offers the lexicographer the material which would enable him to specify the register, level and use of a given word. The database presented in this article is intended to fill this gap by indexing terms from a wide range of texts from the Middle Ages to the present day. In this way, it is possible to obtain images of the language according to the period or context of writing.

Nowadays landscape Atlases cover a great part of mainland France. Beyond their great diversity they all try to describe landscape units of their territories. In order to clarify the situation, the French department of ecology and sustainable development defined a specific vocabulary to link landscape and scales of observation : landscape unit, landscape structure, landscape element. Remote sensing, linked with a land approach, allows identification and cartography of some differents landscape types, and therefore of the landscape structures, particularly with the object-oriented approach. This method is based on the classification of segmented objects extracted from a high-resolution satellite image. This study shows an example picked up on the Pays de Saint-Brieuc, in Côtes d’Armor (France), and deals specifically with the case of the valleys, which strongly structure this space.

In the early 1970s, at the request of Mr Falc’hun, I agreed to take charge of the creation of a New linguistic atlas of Lower Brittany (NALBB). At the time, I was far from imagining the heaviness of the task, which required a full-time job. Apart from the time spent in the field, the most tedious part is the phonetic transcription of the results. As the first series of surveys is nearing completion, the rest of the work remains to be done. However, it is impossible for me to carry out this task alone for the same reasons I have just mentioned. The other reason is demographic: time is running out for the vernacular languages, which are disappearing with their speakers. I therefore call on those interested to collaborate in the project.

Landscapes are closely linked to human well-being, but they are undergoing rapid and fundamental change. Understanding the societal transformation underlying these landscape changes, as well as the ecological and societal outcomes of landscape transformations across scales are prime areas for landscape research. We review and synthesize findings from six important areas of landscape research in Europe and discuss how these findings may advance the study of ecosystem change and society and its thematic key priorities. These six areas are: (1) linkages between people and the environment in landscapes, (2) landscape structure and land-use intensity, (3) long-term landscape history, (4) driving forces, processes, and actors of landscape change, (5) landscape values and meanings, and (6) landscape stewardship. We propose that these knowledge areas can contribute to the study of ecosystem change and society, considering nested multiscale dynamics of social-ecological systems; the stewardship of these systems and their ecosystem services; and the relationships between ecosystem services, human well-being, wealth, and poverty. Our synthesis highlights that knowledge about past and current landscape patterns, processes, and dynamics provides guidance for developing visions to support the sustainable stewardship of social-ecological systems under future conditions.

This text is the introduction to the conference "Is there a French sociolinguistic exception? In the first part, the authors recall the principles, notions and categories that allow us to identify and order the words that surround any speaker (idiom and institution, parity and disparity, badumes, standards and norm). Secondly, they analyse, with the help of these notions, the sociolinguistic evolution of France from the French Revolution to the mid-1990s.