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2 results on '"Laura del-Olmo-Iruela"'

1. Evaluation of the effects of a gamified, fully immersive and stroke-specific virtual reality intervention for improving disability and quality of life in patients with stroke in the subacute phase: study protocol of the RESET randomised trial

Author

Jonatan R Ruiz, Francisco J Amaro-Gahete, Patricia Martínez-Sánchez, Silvia Gómez-García, Pablo Jorge Marcos-Pardo, Alberto Soriano-Maldonado, David Ruiz-González, Alba Hernández-Martínez, Manuel Fernandez-Escabias, Laura Amaya-Pascasio, Sofia Carrilho-Candeias, Máriam Ramos-Teodoro, Mercedes Gil-Rodríguez, Andrea Orellana-Jaen, Elena Martínez-Rosales, Alba Esteban-Simón, Belén Castro-Ropero, Laura del-Olmo-Iruela, María Isabel López-López, Ana Isabel Ramos-Herrera, Manuel F. Fajardo-Rodríguez, Marta Rodríguez-Camacho, Elena Conde-Negri, Mónica Rodríguez-Pérez, and Inmaculada Villegas-Rodríguez

Subjects
Medicine (General), R5-920
Abstract

Stroke is the leading cause of disability and the second cause of death worldwide. The increasing burden of stroke underscores the importance of optimising rehabilitation protocols. Virtual reality (VR) can improve poststroke prognosis. A VR software combining gamification, full immersion and stroke specificity (ie, the Development and validation of a novel viRtual rEality software for improving diSability and quality of lifE in patients with sTroke (RESET) software) might substantially improve disability and quality of life (QoL). However, this technology is still very scarce. The RESET trial aims to assess the effects of an early 10-week gamified, fully immersive and stroke-specific VR intervention (ie, starting at week 3 poststroke) on disability and QoL in people with stroke in the subacute phase. People with ischaemic or haemorrhagic stroke (n=94) aged ≥18 years will be randomised to receive (1) usual care (UC), (2) commercial VR or (3) gamified, fully immersive and stroke-specific VR (RESET). The three groups will receive UC (ie, three sessions/week of 90 min of standard rehabilitation). The VR groups will additionally receive three VR sessions of 20 min per week. The outcome measures will be assessed at baseline (week 2 from stroke occurrence), week 13 (approximately 90 days from the event) and week 26 (approximately 6 months from the event). The primary outcome is disability measured with the Barthel Index. Secondary outcomes include QoL, upper-extremity and lower-extremity motor function, gross manual dexterity, handgrip strength and cognitive function. This study will unravel the effects of a gamified, fully immersive and stroke-specific VR software on disability and QoL in patients with stroke in the early subacute phase.NCT06132399.

Published
2024
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2. Large volume sample stacking in capillary zone electrophoresis for the monitoring of the degradation products of metribuzin in environmental samples

Author

Laura del Olmo-Iruela, Monsalud del Olmo, Ana M. García-Campaña, and Carolina Quesada-Molina

Subjects
Detection limit, Sorbent, Chromatography, Soil test, Molecular Structure, Chemistry, Herbicides, Triazines, Organic Chemistry, Analytical chemistry, Electrophoresis, Capillary, Reproducibility of Results, General Medicine, Biochemistry, Acid dissociation constant, Analytical Chemistry, Solvent, Soil, Capillary electrophoresis, Sample preparation, Solid phase extraction
Abstract

A capillary zone electrophoresis (CZE) method with UV-vis detection has been developed for the simultaneous monitoring of the major degradation products of metribuzin, i.e. deaminometribuzin (DA), deaminodiketometribuzin (DADK) and diketometribuzin (DK). The dissociation acid constants have also been estimated by CE and no significant differences have been observed with the values obtained by applying other techniques. Optimum separation has been achieved in less than 9 min in 40 mM sodium tetraborate buffer, pH 9.5 by applying a voltage of 15kV at 25 degrees C and using p-aminobenzoic acid as internal standard. In order to increase sensitivity, large volume sample stacking (LVSS) with polarity switching has been applied as on-line pre-concentration methodology. Detection limits of 10, 10 and 20 ng/mL for DA, DADK and DK, respectively were obtained. The method has been applied to soil samples, after pressurized liquid extraction (PLE). Samples were extracted at high temperature (103 degrees C and 1500 psi) using methanol as extraction solvent and sodium sulphate as drying agent. This PLE procedure was followed by an off-line pre-concentration and sample clean-up procedure by solid-phase extraction (SPE) using a LiChrolut EN sorbent column. These last two procedures were also suitable for the direct treatment of groundwater samples before CE analysis. The combination of both off-line and on-line pre-concentration procedures provided a significant improvement in sensitivity. LVSS provided pre-concentration factors of 4, 36 and 28 for DK, DA and DADK, respectively and with SPE a pre-concentration of 500-fold for the case of water samples and of 2.5-fold in the case of soil samples was obtained. The method is suitable for the monitoring of these residues in environmental samples with high sensitivity, precision and satisfactory recoveries.

Published
2007

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