10 results on '"Laura Giordo"'
Search Results
2. Stroke and stroke-like episodes in inborn errors of metabolism: Pathophysiological and clinical implications
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Mario Mastrangelo, Giacomina Ricciardi, Laura Giordo, Manuela De Michele, Danilo Toni, and Vincenzo Leuzzi
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Organic acidopathies ,Urea Cycle Disorders ,Endocrinology, Diabetes and Metabolism ,Mitochondrial Myopathies ,Metabolic diseases ,Mitochondrial diseases ,Urea cycle defects ,Biochemistry ,Stroke ,Endocrinology ,Inborn ,Genetics ,MELAS Syndrome ,Humans ,Fabry Disease ,Congenital disorders of glycosylation ,Metabolic stroke ,Molecular Biology ,Urea Cycle Disorders, Inborn - Abstract
Inborn errors of metabolism causing stroke (ischemic or haemorrhagic) or stroke-like episodes (e.g., that are also called "metabolic strokes" and include acute brain lesions not related with alterations of blood flow) cover a wide range of diseases in which acute metabolic decompensations after trigger events (e.g., fever, dehydration, sepsis etc.) may have a variable frequency. The early diagnosis of these conditions is essential because, despite their rarity, effective symptomatic treatments may be available for acute settings (e.g., arginine for Mitochondrial myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like episodes- MELAS) while in other cases disease modifying therapies may be useful to prevent stroke occurrence, recurrence, or relapse (e.g., Fabry disease). The detection of a non-vascular distribution of lesions and the diffuse use of
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- 2022
3. Acute ischemic stroke in childhood: a comprehensive review
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Danilo Toni, Giacomina Ricciardi, Laura Giordo, Manuela De Michele, Vincenzo Leuzzi, and Mario Mastrangelo
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Pediatrics ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Neuroimaging ,Review ,law.invention ,Brain Ischemia ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,030225 pediatrics ,Medicine ,Pediatric stroke ,Humans ,Thrombolytic Therapy ,Recanalization therapies ,Child ,Acute ischemic stroke ,Stroke ,Children ,Ischemic Stroke ,Randomized Controlled Trials as Topic ,business.industry ,Incidence (epidemiology) ,Infant, Newborn ,Thrombolysis ,medicine.disease ,Treatment Outcome ,Pediatrics, Perinatology and Child Health ,Diagnostic protocol ,business ,Live birth ,Intracranial Hemorrhages ,030217 neurology & neurosurgery - Abstract
This review provides an updated analysis of the main aspects involving the diagnosis and the management of children with acute ischemic stroke. Acute ischemic stroke is an emergency of rare occurrence in children (rate of incidence of 1/3500 live birth in newborns and 1–2/100,000 per year during childhood with peaks of incidence during the perinatal period, under the age of 5 and in adolescence). The management of ischemic stroke in the paediatric age is often challenging because of pleomorphic age-dependent risk factors and aetiologies, high frequency of subtle or atypical clinical presentation, and lacking evidence-based data about acute recanalization therapies. Each pediatric tertiary centre should activate adequate institutional protocols for the optimization of diagnostic work-up and treatments.Conclusion: The implementation of institutional standard operating procedures, summarizing the steps for the selection of candidate for neuroimaging among the ones presenting with acute neurological symptoms, may contribute to shorten the times for thrombolysis and/or endovascular treatments and to improve the long-term outcome. What is Known:•Acute ischemic stroke has a higher incidence in newborns than in older children (1/3500 live birth versus 1–2/100,000 per year).•Randomized clinical trial assessing safety and efficacy of thrombolysis and/or endovascular treatment were never performed in children What is New:•Recent studies evidenced a low risk (2.1% of the cases) of intracranial haemorrhages in children treated with thrombolysis.•A faster access to neuroimaging and hyper-acute therapies was associated with the implementation of institutional protocols for the emergency management of pediatric stroke.
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- 2021
4. Two Cases of Selective Mutism: To Speak Does Not Mean to Recover
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Maria Romani, Laura Giordo, Elena Arigliani, and Miriam Vigliante
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Conduct Disorder ,Male ,Pediatrics ,medicine.medical_specialty ,Adolescent ,Mutism ,Parenting ,business.industry ,Depression ,Selective mutism ,MEDLINE ,Child Behavior ,Anxiety ,medicine.disease ,Psychotherapy ,Adolescent Behavior ,Attention Deficit and Disruptive Behavior Disorders ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,medicine ,Humans ,Female ,business - Published
- 2020
5. Impaired flow-mediated dilation in hospitalized patients with community-acquired pneumonia
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Cristiana Franchi, Michela Mordenti, Marco Falcone, Ludovica Perri, Maurizio De Angelis, Elisabetta Rossi, Daniele Pastori, Filippo Toriello, Lucia Fontanelli Sulekova, Giulio Francesco Romiti, Rozenn Esvan, Paolo Marinelli, Luisa Solimando, Marco Antonio Casciaro, Stefano Trapè, Paolo De Marzio, Elisa Catasca, Lorenzo Loffredo, Roberto Carnevale, Eleonora Ruscio, S. Grieco, Camilla Calvieri, Alessandro Russo, Cinzia Myriam Calabrese, Francesco Violi, Andrea Celestini, Cristina Nocella, Simona Battaglia, Gloria Taliani, Roberto Cangemi, Laura Giordo, Maria Gabriella Scarpellini, Elisa Biliotti, Francesco Equitani, Lucia Fazi, Elisa Manzini, Giuliano Bertazzoni, Pasquale Pignatelli, Domenico Ferro, Sergio Morelli, Marco Rivano Capparuccia, Tommaso Bucci, and Paolo Palange
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Lipopolysaccharides ,Male ,medicine.medical_specialty ,Brachial Artery ,Pneumonia severity index ,Flow mediated dilation ,Isoprostanes ,030204 cardiovascular system & hematology ,medicine.disease_cause ,Nitric oxide ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Community-acquired pneumonia ,Internal medicine ,Internal Medicine ,medicine ,Humans ,oxidative stress ,pneumonia ,flow-mediated dilation ,Prospective Studies ,030212 general & internal medicine ,Myocardial infarction ,Endothelial dysfunction ,Intensive care medicine ,Nitrites ,Aged ,Ultrasonography ,Aged, 80 and over ,Nitrates ,business.industry ,Type 2 Diabetes Mellitus ,Middle Aged ,medicine.disease ,infection ,Community-Acquired Infections ,Hospitalization ,Vasodilation ,chemistry ,Cardiology ,Female ,Endothelium, Vascular ,internal medicine ,business ,Oxidative stress - Abstract
Community-acquired pneumonia (CAP) is complicated by cardiovascular events as myocardial infarction and stroke but the underlying mechanism is still unclear. We hypothesized that endothelial dysfunction may be implicated and that endotoxemia may have a role.Fifty patients with CAP and 50 controls were enrolled. At admission and at discharge, flow-mediated dilation (FMD), serum levels of endotoxins and oxidative stress, as assessed by serum levels of nitrite/nitrate (NOx) and isoprostanes, were studied.At admission, a significant difference between patients with CAP and controls was observed for FMD (2.1±0.3 vs 4.0±0.3%, p0.001), serum endotoxins (157.8±7.6 vs 33.1±4.8pg/ml), serum isoprostanes (341±14 vs 286±10 pM, p=0.009) and NOx (24.3±1.1 vs 29.7±2.2μM). Simple linear correlation analysis showed that serum endotoxins significantly correlated with Pneumonia Severity Index score (Rs=0.386, p=0.006). Compared to baseline, at discharge CAP patients showed a significant increase of FMD and NOx (from 2.1±0.3 to 4.6±0.4%, p0.001 and from 24.3±1.1 to 31.1±1.5μM, p0.001, respectively) and a significant decrease of serum endotoxins and isoprostanes (from 157.8±7.6 to 55.5±2.3pg/ml, p0.001, and from 341±14 to 312±14 pM, p0.001, respectively). Conversely, no changes for FMD, NOx, serum endotoxins and isoprostanes were observed in controls between baseline and discharge. Changes of FMD significantly correlated with changes of serum endotoxins (Rs=-0.315; p=0.001).The study provides the first evidence that CAP is characterized by impaired FMD with a mechanism potentially involving endotoxin production and oxidative stress.
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- 2016
6. Corticosteroid use and incident myocardial infarction in adults hospitalized for community-acquired pneumonia
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Roberto Cangemi, Marco Falcone, Gloria Taliani, Camilla Calvieri, Giusy Tiseo, Giulio Francesco Romiti, Giuliano Bertazzoni, Alessio Farcomeni, Francesco Violi, Simona Battaglia, Elisa Biliotti, Cinzia Myriam Calabrese, Andrea Celestini, Marco Casciaro, Maurizio De Angelis, Ilaria Di Diego, Paolo De Marzio, Rozenn Esvan, Giovanni Ferraro, Lucia Fontanelli Sulekova, Cristiana Franchi, Laura Giordo, Fuad Khoury, Sergio Morelli, Giulia Naspi Catassi, Paolo Palange, Daniele Pastori, Anna Prosperi, Valeria Raparelli, Marco Rivano Capparuccia, Elisabetta Rossi, Maria Gabriella Scarpellini, Stefano Trapè, Filippo Toriello, Marco Vano, and Mario Venditti
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Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Kaplan-Meier Estimate ,corticosteroids ,myocardial infarction ,pneumonia ,NO ,03 medical and health sciences ,0302 clinical medicine ,Community-acquired pneumonia ,Adrenal Cortex Hormones ,Risk Factors ,Prednisone ,Internal medicine ,Epidemiology ,medicine ,Humans ,Corticosteroids ,Hospital Mortality ,030212 general & internal medicine ,Myocardial infarction ,Propensity Score ,Aged ,Proportional Hazards Models ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Incidence ,Retrospective cohort study ,Pneumonia ,Middle Aged ,medicine.disease ,Community-Acquired Infections ,Italy ,030228 respiratory system ,Methylprednisolone ,Corticosteroids, Myocardial infarction, Pneumonia, pulmonary and respiratory medicine ,Betamethasone ,Female ,business ,Settore SECS-S/01 - Statistica ,medicine.drug - Abstract
Adults hospitalized for community-acquired pneumonia (CAP) have an increased risk of myocardial infarction. Corticosteroid treatment lowers CAP morbidity and mortality, but it is not known whether it influences in-hospital myocardial infarction.The aim of the present study was to investigate the potential interplay between corticosteroid treatment and in-hospital myocardial infarction in adults with CAP.We retrospectively analyzed adults with CAP referred to the University Hospital Policlinico Umberto I (Rome, Italy), consecutively recruited, and prospectively followed until discharge. The primary outcome was the occurrence of myocardial infarction during hospitalization. We used propensity score-adjusted Cox models to examine the association between corticosteroid use and myocardial infarction.Seven hundred fifty-eight patients (493 males, 265 females; mean ± standard deviation age, 71.7 ± 14.4 yr) were included in the study. Of these, 241 (32%) were treated with systemic corticosteroids (methylprednisolone, betamethasone, or prednisone). During follow-up, 62 (8.2%) had a myocardial infarction during their hospitalization (incidence, 0.72 per 100 person-days; 95% confidence interval [CI], 0.55 to 0.92). Those treated with corticosteroids had a lower incidence of myocardial infarction (0.42 per 100 person-days) than those not treated with corticosteroids (0.89 per 100 person-days; absolute rate difference, -0.48 per 100 person-days; 95% CI, -0.85 to -0.10). In a propensity score-adjusted Cox model, corticosteroid use was associated with a lower incidence of myocardial infarction (hazard ratio, 0.46; 95% CI, 0.24 to 0.88; P = 0.02).We found that in-hospital corticosteroid treatment was associated with a lower incidence of myocardial infarction in adults hospitalized with CAP.
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- 2019
7. Neurophysiological correlates of bradykinesia in Parkinson's disease
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Annarita Vestri, Laura Giordo, John C. Rothwell, Alfredo Berardelli, Matteo Bologna, Andrea Guerra, Danilo Alunni Fegatelli, and Giulia Paparella
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0301 basic medicine ,Male ,Parkinson's disease ,medicine.medical_treatment ,Movement ,Neurophysiology ,Hypokinesia ,Levodopa ,03 medical and health sciences ,0302 clinical medicine ,Dopamine ,Medicine ,Aged ,Biomechanical Phenomena ,Evoked Potentials, Motor ,Female ,Humans ,Middle Aged ,Motor Cortex ,Neuronal Plasticity ,Parkinson Disease ,Transcranial Magnetic Stimulation ,Evoked Potentials ,Repetitive finger tapping ,business.industry ,Dopaminergic ,medicine.disease ,Transcranial magnetic stimulation ,030104 developmental biology ,Motor ,Facilitation ,Neurology (clinical) ,Primary motor cortex ,business ,Neuroscience ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Many neurophysiological abnormalities have been described in the primary motor cortex of patients with Parkinson's disease. However, it is unclear whether there is any relationship between them and bradykinesia, one of the cardinal motor features of the condition. In the present study we aimed to investigate whether objective measures of bradykinesia in Parkinson's disease have any relationship with neurophysiological measures in primary motor cortex as assessed by means of transcranial magnetic stimulation techniques. Twenty-two patients with Parkinson's disease and 18 healthy subjects were enrolled. Objective measurements of repetitive finger tapping (amplitude, speed and decrement) were obtained using a motion analysis system. The excitability of primary motor cortex was assessed by recording the input/output curve of the motor-evoked potentials and using a conditioning-test paradigm for the assessment of short-interval intracortical inhibition and facilitation. Plasticity-like mechanisms in primary motor cortex were indexed according to the amplitude changes in motor-evoked potentials after the paired associative stimulation protocol. Patients were assessed in two sessions, i.e. OFF and ON medication. A canonical correlation analysis was used to test for relationships between the kinematic and neurophysiological variables. Patients with Parkinson's disease tapped more slowly and with smaller amplitude than normal, and displayed decrement as tapping progressed. They also had steeper input/output curves, reduced short-interval intracortical inhibition and a reduced response to the paired associative stimulation protocol. Within the patient group, bradykinesia features correlated with the slope of the input/output curve and the after-effects of the paired associative stimulation protocol. Although dopaminergic therapy improved movement kinematics as well as neurophysiological measures, there was no relationship between them. In conclusion, neurophysiological changes in primary motor cortex relate to bradykinesia in patients with Parkinson's disease, although other mechanisms sensitive to dopamine levels must also play a role.
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- 2018
8. Low-grade endotoxemia, gut permeability and platelet activation in community-acquired pneumonia
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Sergio Morelli, Maria Gabriella Scarpellini, Marco Falcone, Lucia Fazi, Gloria Taliani, Francesco Violi, Elisa Biliotti, Filippo Toriello, Cristiana Franchi, Daniele Pastori, Giulio Francesco Romiti, Roberto Carnevale, Stefano Trapè, Marco Antonio Casciaro, Paolo De Marzio, Giuliano Bertazzoni, Cinzia Myriam Calabrese, Laura Giordo, Simona Bartimoccia, Roberto Cangemi, Domenico Ferro, Pasquale Pignatelli, Marco Rivano Capparuccia, Maurizio De Angelis, S. Grieco, Paolo Palange, Elisa Manzini, Eleonora Ruscio, Cristina Nocella, Rozenn Esvan, Alessandro Russo, Simona Battaglia, Elisabetta Rossi, and Lucia Fontanelli Sulekova
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Microbiology (medical) ,Adult ,Lipopolysaccharides ,Male ,P-selectin ,Lipopolysaccharide ,030204 cardiovascular system & hematology ,Blood platelets ,Endotoxins ,NADPH oxidase ,Pneumonia ,Infectious Diseases ,Permeability ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Community-acquired pneumonia ,medicine ,Humans ,Platelet ,030212 general & internal medicine ,Platelet activation ,Aged ,Membrane Glycoproteins ,biology ,business.industry ,Zonulin ,NADPH Oxidases ,Middle Aged ,medicine.disease ,Platelet Activation ,Endotoxemia ,Community-Acquired Infections ,Intestines ,P-Selectin ,chemistry ,Immunology ,NADPH Oxidase 2 ,biology.protein ,Female ,business - Abstract
Platelet activation seems to be implicated in the cardiovascular events occurring in patients with community-acquired pneumonia (CAP) but the underlying mechanism is still unclear. Aim of the study was to assess the mechanism involved in platelet activation in CAP patients.Two-hundred-seventy-eight consecutive patients hospitalized for CAP were recruited and followed-up until discharge. Hospitalized patients matched for sex, age and comorbidities but without acute infectious diseases were used as controls.At hospital admission patients disclosed enhanced plasma levels of sP-selectin, a maker of in-vivo platelet activation, serum sNOX2-dp, a marker of NADPH-oxidase activation, serum Lipopolysaccharide (LPS) and serum zonulin, a marker of gut permeability, compared to controls (p 0.001). Baseline sP-selectin was independently associated to serum LPS, sNOX2-sp and Pneumonia Severity Index score (p 0.001). Plasma sP-selectin, serum sNOX2-dp, LPS and zonulin coincidentally decreased at hospital discharge (p 0.001). An in vitro study showed that LPS, at concentration similar to that found in CAP patients, induced sP-selectin release by agonist-activated platelets, a phenomenon that was counteract by treating cells with gp91ds-tat, a specific inhibitor of NOX2.CAP patients display enhanced platelet activation, which is related to LPS-mediated NOX2 activation. Enhanced gut permeability seems be implicated in enhancing circulating levels of LPS.
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- 2016
9. Hospitalization for Pneumonia is Associated With Decreased 1-Year Survival in Patients With Type 2 Diabetes: Results From a Prospective Cohort Study
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Alessio Farcomeni, Laura Giordo, Paolo Palange, Giusy Tiseo, Roberto Cangemi, Francesco Violi, Gloria Taliani, Giuliano Bertazzoni, Mario Venditti, Marco Falcone, Alessandro Russo, Vincenzo Vullo, and Elisa Manzini
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Observational Study ,Type 2 diabetes ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Diabetes mellitus ,medicine ,Humans ,030212 general & internal medicine ,Prospective Studies ,Prospective cohort study ,Intensive care medicine ,Aged ,Aged, 80 and over ,business.industry ,Medicine (all) ,Mortality rate ,urinary tract infections ,diabetes mellitus ,asymptomatic bacteriuria ,General Medicine ,Pneumonia ,medicine.disease ,Hospitalization ,Diabetes Mellitus, Type 2 ,Italy ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,Female ,Hemodialysis ,business ,Kidney disease ,Cohort study ,Research Article - Abstract
Supplemental Digital Content is available in the text, Diabetes mellitus is a frequent comorbid conditions among patients with pneumonia living in the community. The aim of our study is to evaluate the impact of hospitalization for pneumonia on early (30 day) and late mortality (1 year) in patients with type 2 diabetes mellitus. Prospective comparative cohort study of 203 patients with type 2 diabetes hospitalized for pneumonia versus 206 patients with diabetes hospitalized for other noninfectious causes from January 2012 to December 2013 at Policlinico Umberto I (Rome). Enrolled patients were followed up to discharge and up to 1 year after initial hospital admission or death. Overall, 203 patients with type 2 diabetes admitted to hospital for pneumonia were compared to 206 patients with type 2 diabetes admitted for other causes (39.3% decompensated diabetes, 21.4% cerebrovascular diseases, 9.2% renal failure, 8.3% acute myocardial infarction, and 21.8% other causes). Compared to control patients, those admitted for pneumonia showed a higher 30-day (10.8% vs 1%, P
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- 2016
10. Relation of Cardiac Complications in the Early Phase of Community-Acquired Pneumonia to Long-Term Mortality and Cardiovascular Events
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Roberto Cangemi, Sergio Morelli, Maria Gabriella Scarpellini, Lucia Fazi, Francesco Barillà, Francesco Violi, Elisa Manzini, Gloria Taliani, Cristiana Franchi, Camilla Calvieri, Simona Battaglia, Elisabetta Rossi, Marco Antonio Casciaro, Lucia Fontanelli Sulekova, Daniele Pastori, Laura Giordo, Paolo Marinelli, Giulio Francesco Romiti, Luisa Solimando, Alessandro Russo, Marco Falcone, Filippo Toriello, Pasquale Pignatelli, S. Grieco, Michela Mordenti, Maurizio De Angelis, Giuliano Bertazzoni, Paolo Palange, Elisa Biliotti, Stefano Trapè, Paolo De Marzio, Cinzia Myriam Calabrese, Marco Rivano Capparuccia, Tommaso Bucci, Eleonora Ruscio, and Rozenn Esvan
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Male ,medicine.medical_specialty ,community-acquired pneumonia ,Time Factors ,Aged ,80 and over ,Cardiovascular Diseases ,Community-Acquired Infections ,Female ,Follow-Up Studies ,Hospitalization ,Humans ,Middle Aged ,Pneumonia ,Prospective Studies ,Risk Factors ,Survival Analysis ,Medicine (all) ,Cardiology and Cardiovascular Medicine ,Settore MED/11 ,cardiovascular events ,Community-acquired pneumonia ,Internal medicine ,medicine ,Clinical endpoint ,Myocardial infarction ,Prospective cohort study ,Stroke ,Survival analysis ,Aged, 80 and over ,business.industry ,mortality ,Atrial fibrillation ,medicine.disease ,Cardiology ,business - Abstract
Community-acquired pneumonia (CAP) is complicated by cardiac events in the early phase of the disease. Aim of this study was to assess if these intrahospital cardiac complications may account for overall mortality and cardiovascular events occurring during a long-term follow-up. Three hundred one consecutive patients admitted to the University-Hospital, Policlinico Umberto I, with community-acquired pneumonia were prospectively recruited and followed up for a median of 17.4 months. Primary end point was the occurrence of death for any cause, and secondary end point was the occurrence of cardiovascular events (cardiovascular death, nonfatal myocardial infarction [MI], and stroke). During the intrahospital stay, 55 patients (18%) experienced a cardiac complication. Of these, 32 had an MI (29 non-ST-elevation MI and 3 ST-elevation MI) and 30 had a new episode of atrial fibrillation (7 nonmutually exclusive events). During the follow-up, 89 patients died (51% of patients with an intrahospital cardiac complication and 26% of patients without, p0.001) and 73 experienced a cardiovascular event (47% of patients with and 19% of patients without an intrahospital cardiac complication, p0.001). A Cox regression analysis showed that intrahospital cardiac complications, age, and Pneumonia Severity Index were significantly associated with overall mortality, whereas intrahospital cardiac complications, age, hypertension, and diabetes were significantly associated with cardiovascular events during the follow-up. In conclusion, this prospective study shows that intrahospital cardiac complications in the early phase of pneumonia are associated with an enhanced risk of death and cardiovascular events during long-term follow-up.
- Published
- 2015
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