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Impaired flow-mediated dilation in hospitalized patients with community-acquired pneumonia
- Source :
- European Journal of Internal Medicine. 36:74-80
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Community-acquired pneumonia (CAP) is complicated by cardiovascular events as myocardial infarction and stroke but the underlying mechanism is still unclear. We hypothesized that endothelial dysfunction may be implicated and that endotoxemia may have a role.Fifty patients with CAP and 50 controls were enrolled. At admission and at discharge, flow-mediated dilation (FMD), serum levels of endotoxins and oxidative stress, as assessed by serum levels of nitrite/nitrate (NOx) and isoprostanes, were studied.At admission, a significant difference between patients with CAP and controls was observed for FMD (2.1±0.3 vs 4.0±0.3%, p0.001), serum endotoxins (157.8±7.6 vs 33.1±4.8pg/ml), serum isoprostanes (341±14 vs 286±10 pM, p=0.009) and NOx (24.3±1.1 vs 29.7±2.2μM). Simple linear correlation analysis showed that serum endotoxins significantly correlated with Pneumonia Severity Index score (Rs=0.386, p=0.006). Compared to baseline, at discharge CAP patients showed a significant increase of FMD and NOx (from 2.1±0.3 to 4.6±0.4%, p0.001 and from 24.3±1.1 to 31.1±1.5μM, p0.001, respectively) and a significant decrease of serum endotoxins and isoprostanes (from 157.8±7.6 to 55.5±2.3pg/ml, p0.001, and from 341±14 to 312±14 pM, p0.001, respectively). Conversely, no changes for FMD, NOx, serum endotoxins and isoprostanes were observed in controls between baseline and discharge. Changes of FMD significantly correlated with changes of serum endotoxins (Rs=-0.315; p=0.001).The study provides the first evidence that CAP is characterized by impaired FMD with a mechanism potentially involving endotoxin production and oxidative stress.
- Subjects :
- Lipopolysaccharides
Male
medicine.medical_specialty
Brachial Artery
Pneumonia severity index
Flow mediated dilation
Isoprostanes
030204 cardiovascular system & hematology
medicine.disease_cause
Nitric oxide
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Community-acquired pneumonia
Internal medicine
Internal Medicine
medicine
Humans
oxidative stress
pneumonia
flow-mediated dilation
Prospective Studies
030212 general & internal medicine
Myocardial infarction
Endothelial dysfunction
Intensive care medicine
Nitrites
Aged
Ultrasonography
Aged, 80 and over
Nitrates
business.industry
Type 2 Diabetes Mellitus
Middle Aged
medicine.disease
infection
Community-Acquired Infections
Hospitalization
Vasodilation
chemistry
Cardiology
Female
Endothelium, Vascular
internal medicine
business
Oxidative stress
Subjects
Details
- ISSN :
- 09536205
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- European Journal of Internal Medicine
- Accession number :
- edsair.doi.dedup.....381e295785cc56e6d6309cf5a233ebb3