Search

Across the globe, long-term care has been under increased pressure throughout the COVID-19 pandemic. This is the first study to examine the experiences and needs of long-term care staff and management during COVID-19, in the Canadian context. Our group conducted online survey research with 70 staff and management working at public long-term care facilities in central Canada, using validated quantitative measures to examine perceived stress and caregiver burden; and open-ended items to explore stressors, ways of coping, and barriers to accessing mental health supports. Findings indicate moderate levels of stress and caregiver burden, and highlight the significant stressors associated with working in long-term care during the COVID-19 pandemic (i.e., rapid changes in pandemic guidelines, increased workload, “meeting the needs of residents and families”, fear of contracting COVID-19 and COVID-19 coming into long-term care facilities, and concern over a negative public view of long-term care staff and facilities). A small subset (13.2%) of our sample identified accessing mental health supports to cope with work-related stress, with most participants identifying barriers to seeking help. Novel findings of this research highlight the significant and unmet needs of this high-risk segment of the population.

We study the population of active galaxies in void environment in the Sloan Digital Sky Survey. We use optical spectroscopic information to analyse characteristics of the emission lines of galaxies, accomplished by WHAN and BPT diagrams. Also, we study Wide-field Infrared Survey Explorer(WISE) mid-IR colours to assess active galactic nucleus (AGN) activity. We investigate these different AGN classification schemes, both optical and mid-IR, and their dependence on the spatial location with respect to the void centres. To this end, we define three regions: void, the spherical region defined by voidcentric distance relative to void radius (distance/rvoid) smaller than 0.8, comprising overdensities lesser than −0.9, an intermediate/transition shell region (namely, void-wall) 0.8 < distance/rvoid < 1.2, and a region sufficiently distant from voids, the field: distance/rvoid > 2. We find statistical evidence for a larger fraction of AGN and star-forming galaxies in the void region, regardless of the classification scheme addressed (either BPT, WHAN, or WISE). Moreover, we obtain a significantly stronger nuclear activity in voids compared to the field. We find an unusually large fraction of the most massive black holes undergoing strong accretion when their host galaxies reside in voids. Our results suggest a strong influence of the void environment on AGN mechanisms associated with galaxy evolution.

Adjusting identity standards may be preferable to relentless pursuit or abandonment of an identity when facing an identity-challenging life transition. Self-compassion (SC) can help people adjust to challenges. The authors examined whether SC was associated with identity adjustment, exercise, and the moderating effect of identity–behavior discrepancy in 279 women exercisers who reported reduced exercise in motherhood. Participants completed the Self-Compassion Scale and reported the extent of and reflected on their identity discrepant behavior (reduced exercise). Reactions to discrepancy (acceptance, shame, guilt, and rumination), correlates of identity adjustment (subjective well-being, autonomous motivation, controlled motivation, and role conflict), and exercise behavior were assessed. SC associated positively with acceptance, correlates of successful identity adjustment, and exercise behavior. SC associated negatively with shame, rumination, and correlates of unsuccessful adjustment. SC may help exercise-identifying women who exercise less after becoming mothers adaptively cope with this identity challenge and continue exercising.

Posttraumatic stress disorder (PTSD) is associated with various physical health conditions. However, it is unclear whether the relationship between PTSD and physical health conditions differs according to age. This study aims to examine the associations between PTSD and physical health conditions across four adult age categories.We analyzed data from the 2012 to 2013 National Epidemiologic Survey on Alcohol and Related Conditions (The prevalence of nearly all physical health conditions increased according to age, whereas the prevalence of PTSD tended to decrease with age. After adjustment, PTSD was associated with a greater number of physical health conditions among all age categories (PTSD is associated with many physical health conditions across the age spectrum, particularly among younger and middle-aged adults. Results may inform targeted screening and intervention strategies to mitigate risk of physical health conditions among adults with PTSD.

Previously, we showed that university athletes demonstrate cardiac reactivity resembling an acute stress response while recalling a previous sport failure. Athletes who reported higher levels of self- compassion showed greater elevation of parasympathetic nervous system reactivity during recall of failure, and also showed more adaptive behavioural reactions, less maladaptive thoughts, and less negative affect during the task. Here, we analyzed changes in power spectra of the electroencephalogram (EEG) before, during, and after the recall of a previous sports failure, and whether individual differences in self-compassion or related constructs impact EEG changes during recall. Significant reactivity to, and recovery from, the recall task was observed across all EEG bandwidths: delta power decreased, and theta, low alpha, high alpha, low beta, and high beta power all increased from baseline to recall. Analogous EEG power changes were observed during recovery: delta power increased, while theta, low alpha, high alpha, low beta, and high beta power all decreased to baseline levels. Large gender differences were observed, with females generally showing greater EEG power across bandwidths during all phases of the experiment. Higher levels of self-compassion were associated with reduced theta power at baseline and during the recovery phase. Reactivity and recovery scores of EEG power were associated with self-reported self-esteem in the low alpha band: individuals reporting higher self-esteem showed greater increases in low alpha power during the recall task and greater decreases in low alpha power during recovery. These results are amongst the first to examine EEG power changes during experiences of acute stress and may have implications for improving how athletes recover from failures in sporting events.

Failure inherent to high-performance sport can precipitate emotional distress that can impair athletes’ performance and physical and mental health. Identifying factors that allow athletes to manage failure to sustain their health is critical. Self-compassion, treating oneself kindly in response to failure, may help athletes manage failure; it buffers against negative affective psychological responses, yet athletes often fear self-compassion. It is unknown whether the benefits of self-compassion extend to athletes’ physiological responses to failure and whether fear of self-compassion has an influence on psychological and physiological responses to failure, beyond self-compassion. The purpose of this study was to examine the influence of self-compassion on athletes’ psychological and physiological responses when recalling a sport failure and determine if fear of self-compassion exerted unique effects, beyond self-compassion. Participants (n = 91; M age = 21) were university or national-level athletes. In this laboratory-based, observational study, athletes were connected to a multi-modal biofeedback system to measure physiological responding at baseline, during a stress induction (imagining a past performance failure), and during a recovery period. Physiological responding was assessed according to athletes’ high-frequency heart rate variability (HRV), indexing parasympathetic nervous system activity, during the stress induction and recovery phase. Next, to assess psychological reactivity, athletes completed a series of scales (behavioral reactions, thoughts, and emotions). Regression analyses revealed that self-compassion predicted athletes’ HRV reactivity to the stress induction (β = 0.30, p < 0.05). There was no relationship between self-compassion and HRV recovery. Further, self-compassion predicted adaptive behavioral reactions (β = 0.46, p < 0.01), and negatively predicted maladaptive thoughts (β = −0.34, p < 0.01) and negative affect (β = −0.39, p < 0.01). Fear of self-compassion explained additional variance in some maladaptive thoughts and behavioral reactions. Results suggest that self-compassion promotes adaptive physiological and psychological responses in athletes relative to a recalled sport failure and may have implications for performance enhancement, recovery and health outcomes. Further, addressing athletes’ fears of self-compassion may also be important in promoting optimal psychological recovery.

Engaging in health-promoting behaviours has health benefits for people with prediabetes or diabetes. People experience negative affect after diagnoses, which can impede self-regulation of health behaviours. Self-compassion, extending care to oneself in difficult times, can mitigate negative affect and promote self-regulation. This scoping review explored the relationship between self-compassion and adaptive affect, self-regulation and engagement in health-promoting/management behaviours among people with prediabetes or diabetes. We conducted a scoping literature search from 6 databases for studies and conference abstracts. Randomized controlled trials and cross-sectional, longitudinal, observational and qualitative designs focused on self-compassion were included. Eligible studies included adults with diabetes (prediabetes, type 1, type 2 and gestational), measured self-compassion using a validated Self-Compassion Scale (quantitative) or included the 3 components (qualitative) and investigated: negative affect, health promoting/management behaviours and/or self-regulation. After deduplication, 5,338 quantitative and 953 qualitative abstracts, and 18 conference proceedings were screened leaving 35 articles. Full-text screening retained 11 eligible studies (6 cross-sectional studies, 2 randomized controlled trials, 2 longitudinal studies and 1 qualitative study). Higher self-compassion was associated with decreased negative affect in 9 studies and was positively associated with well-being in 1 cross-sectional study. Self-compassion led to decreased negative affect and improved blood glucose in 2 interventions. Five studies found positive associations between self-compassion and health-promoting/management behaviours. One qualitative study found self-compassion to benefit affective reactions, health-promoting behaviours and self-regulation. This review shows that self-compassion is linked to adaptive behavioural and affective responding among people with prediabetes and diabetes, and the need for more research on self-compassion and self-regulation in these populations.

We examined the effects of a self-affirmation intervention in conjunction with message frame on attentional bias toward physical activity messages, and explicit psychological and behavioral responses to these messages. Inactive participants (N = 153) completed either a self-affirmation or a control task, were told they were not active enough for health benefits, then read either a gain or loss-framed message, followed by an attentional bias task and questionnaires measuring message processing, psychological reactions and behavior. One week later, participants completed an on-line measure of physical activity. Message frame did not moderate the self-affirmation effect. Self-affirmed participants reported slightly higher self-efficacy for exercising in the future and slightly lower, but not significant, perceived threat than participants in the control group. Self-affirmation and messages may need to be further supplemented with more intense interventions accompanied with adequate resources to facilitate intentions for and actual behavioral change for a complex behavior like physical activity.

We compute the bulk motions of cosmic voids, using a $\Lambda$CDM numerical simulation considering the mean velocities of the dark matter inside the void itself and that of the haloes in the surrounding shell. We find coincident values of these two measures in the range $\sim$ 300-400 km/s, not far from the expected mean peculiar velocities of groups and galaxy clusters. When analysing the distribution of the pairwise relative velocities of voids, we find a remarkable bimodal behaviour consistent with an excess of both systematically approaching and receding voids. We determine that the origin of this bimodality resides in the void large scale environment, since once voids are classified into void-in-void (R-type) or void-in-cloud (S-type), R-types are found mutually receding away, while S-types approach each other. The magnitude of these systematic relative velocities account for more than 100 km/s, reaching large coherence lengths of up to 200 h$^{-1}$ Mpc . We have used samples of voids from the Sloan Digital Sky Survey Data Release 7 (SDSS-DR7) and the peculiar velocity field inferred from linear theory, finding fully consistent results with the simulation predictions. Thus, their relative motion suggests a scenario of a sparkling Universe, with approaching and receding voids according to their local environment., Comment: 6 pages, 4 Figures, accepted for publication in MNRAS Letters

We analyse the clustering of cosmic voids using a numerical simulation and the main galaxy sample from the Sloan Digital Sky Survey. We take into account the classification of voids into two types that resemble different evolutionary modes: those with a rising integrated density profile (void-in-void mode, or R-type) and voids with shells (void-in-cloud mode, or S-type). The results show that voids of the same type have stronger clustering than the full sample. We use the correlation analysis to define void clumps, associations with at least two voids separated by a distance of at most the mean void separation. In order to study the spatial configuration of void clumps, we compute the minimal spanning tree and analyse their multiplicity, maximum length and elongation parameter. We further study the dynamics of the smaller sphere that encloses all the voids in each clump. Although the global densities of void clumps are different according to their member-void types, the bulk motions of these spheres are remarkably lower than those of randomly placed spheres with the same radii distribution. In addition, the coherence of pairwise void motions does not strongly depend on whether voids belong to the same clump. Void clumps are useful to analyse the large-scale flows around voids, since voids embedded in large underdense regions are mostly in the void-in-void regime, were the expansion of the larger region produces the separation of voids. Similarly, voids around overdense regions form clumps that are in collapse, as reflected in the relative velocities of voids that are mostly approaching., Comment: Accepted for publication on MNRAS, 9 pages, 5 figures

The expanding complex pattern of filaments, walls and voids build the evolving cosmic web with material flowing from underdense onto high density regions. Here we explore the dynamical behaviour of voids and galaxies in void shells relative to neighboring overdense superstructures, using the Millenium Simulation and the main galaxy catalogue in Sloan Digital Sky Survey data. We define a correlation measure to estimate the tendency of voids to be located at a given distance from a superstructure. We find voids-in-clouds (S-types) preferentially located closer to superstructures than voids-in-voids (R-types) although we obtain that voids within $\sim40~\mathrm{Mpc}\,\mathrm{h}^{-1}$ of superstructures are infalling in a similar fashion independently of void type. Galaxies residing in void shells show infall towards the closest superstructure, along with the void global motion, with a differential velocity component depending on their relative position in the shell with respect to the direction to the superstructure. This effect is produced by void expansion and therefore is stronger for R-types. We also find that galaxies in void shells facing the superstrucure flow towards the overdensities faster than galaxies elsewere at the same relative distance to the superstructure. The results obtained for the simulation are also reproduced for the SDSS data with a linearized velocity field implementation., 10 pages, 9 figures. Accepted for publication in MNRAS

Summary Objectives To evaluate the role of 18-fluoro-2-deoxyglucose positron emission tomography–computed tomography ( 18 F-FDG-PET–CT) in the diagnosis of infectious endocarditis (IE). Methods We retrospectively examined 27 consecutive patients who were admitted to the Infectious Diseases Department of Tor Vergata University Hospital between 2009 and 2013 with a suspicion of IE. The final IE diagnosis was defined according to the modified Duke criteria, and the microbiological and diagnostic results were collected for each patient. Results Twenty out of 27 patients had a suspected prosthetic valve endocarditis (PVE) and seven had a suspected native valve endocarditis (NVE). Twenty-five out of 27 patients (92%) had a confirmed diagnosis of IE (18/25 PVE and 7/25 NVE); 16 had a positive echocardiography evaluation and 16 had positive 18 F-FDG-PET–CT findings. Echocardiography showed a higher sensitivity as a diagnostic tool for the detection of IE compared to 18 F-FDG-PET–CT (80% vs. 55%). However, a greater number of PVE had positive 18 F-FDG-PET–CT results compared to those with positive echocardiography findings (11/13 vs. 9/13), and overall 89% (16/18) of confirmed PVE resulted 18 F-FDG-PET–CT positive. Analyzing only the cases who underwent transoesophageal echocardiography, 18 F-FDG-PET–CT showed a sensitivity of 85% in PVE (vs. 69% for echocardiography and 77% for the Duke criteria). All seven patients with NVE had a positive echocardiography and negative 18 F-FDG-PET–CT findings ( p Conclusions The results of this study further highlight the limitations of echocardiography in the diagnosis of PVE and the potential advantages of 18 F-FDG-PET–CT in these cases.

We describe a case of an anti-HBs-positive patient who experienced hepatitis B reactivation 18 months after the discontinuation of rituximab and after 12 months of lamivudine prophylaxis. The patient carried a hepatitis B genotype D virus harbouring a single immune escape mutation, sT118K. No consensus guidelines regarding the optimal length of treatment or the best elective drug have been defined for antiviral prophylaxis for HBsAg-negative, anti-HBc- and/or anti-HBs-positive patients undergoing immunosuppressive treatment. Screening based on HBV serological markers and HBV DNA testing is a critical issue to recognise hepatitis B reactivation as early as possible. Furthermore, it is of outstanding importance to identify alternative markers (e.g. cccDNA, HBV core related antigen, etc.), that could be predictive of HBV reactivation.

Currently the prevalence of HIV-1 infection in Cameroon is 5.1%, CRF02_AG subtype is responsible for about 50% of infections. Since an HIV-1 drug resistance test is not yet available widely, accurate data on the prevalence of resistant viral strains are missing. The objective of this study was to determine HIV-1 genetic diversity and to characterize HIV-1 mutations conferring drug resistance among antiretroviral therapy (ART)-naïve and ART-treated patients. A cohort of 239 patients infected with HIV were followed-up between January 2007 and July 2010 in Cameroon. Two hundred and sixteen plasma samples were sequenced for phylogenetic analysis and identification of drug resistance mutations in the HIV-1 pol region. A significant genetic diversity was found: Seven pure subtypes (A1, A3, D, F1, F2, G, H), nine circulating recombinant forms (CRFs: 01_AE, 02_AG, 06cpx, 09cpx, 11cpx, 13cpx, 16cpx, 18cpx, 37cpx) and one new unique recombinant form (URF) (G/F2). The rate of transmitted drug resistance (TDR) in naïve patients was 8.2% (4/49). Around 80% of patients failing a first-line ART harbored a virus with at least one resistance mutation to two antiretroviral (ARV) classes, and 36% of those failing a second-line regimen carried a virus with at least one resistant mutation to three ARV classes. The high level of drug resistance observed in the cohort is alarming because this occurred as a result of only few years of treatment. Adherence to therapy, adequate education of physicians, and the appropriate use of genotypic resistance assay are critical points of intervention for the improvement of patient care.

Dapsone (4,40diaminodiphenyl sulphone) has been used since the middle of the 20th century for leprosy treatment, usually in combination with rifampin and clofazimine. Dapsone hypersensitivity syndrome (DHS) occurs in 0.5-3% of patients treated with this drug. The exact immune mechanism behind this idiosyncratic reaction with multi-organ involvement is unclear. Some genetic and environmental factors, by increasing the production of dapsone-reactive metabolites or affecting the ability of the liver to detoxificate them, may increase the risk of developing DHS. Latency before the onset of symptoms can vary from 2-6 h, in previously sensitised patients, to 6 months [1]. Typical DHS manifestations include high fever, skin rash, malaise, methemoglobinaemia, liver toxicity (jaundice, hepatitis and hepatomegaly) and generalised lymphadenopathy. Acute renal failure, hypersensitivity pneumonia, cholangitis, sensory peripheral neuropathy, pancreatitis and pleural effusion have been reported less frequently [2]. The discontinuation of dapsone and the early initiation of high-dosage systemic corticosteroid therapy are crucial to decrease mortality and morbidity. Scedosporium spp. are hyaline filamentous fungi ubiquitously present in soil, sewage and polluted waters. Although these fungi have a uniform worldwide distribution, they are more commonly found in temperate climates than in tropical climates. The most common species responsible for human disease are Scedosporium apiospermum (teleomorph: Pseudallescheria boydii) and Scedosporium prolificans, both of which are very similar to Aspergillus spp. These pathogens, once mainly known as agents of cutaneous and subcutaneous tissue infections (e.g. maduromycosis) in immunocompetent patients, have recently been reported to cause systemic life-threatening infections in immunocompromised hosts with increasing frequency. Scedosporium-related pneumonia, meningoencephalitis, brain abscesses and endocarditis have been documented in patients with advanced human immunodeficiency virus (HIV) infection and haematological malignancies, as well as in stem cell transplantation recipients. In the international medical literature, there are only a few reports of life-threatening Scedosporium spp. infections in immunocompetent patients. Rodriguez-Tudela et al. [3], in a recent review of 162 cases of scedosporiosis, reported 34 infections in patients with no underlying chronic condition; of note, 23 of these cases (82%) had suffered surgery or traumatism before the acquisition of the infection. Katragkou et al. [4] reviewed 23 cases of Scedosporium apiospermum infection after near-drowning. In this particular condition, Scedosporium apiospermum has been reported to cause severe invasive infections, with frequent central nervous system dissemination, in young and immunocompetent hosts. We report the case of a patient who died of a rapidly progressive pneumonia caused by Scedosporium apiospermum. The patient we describe did not present any typical risk factor for this opportunistic infection, except for a 10-day course of steroid therapy administered to control a DHS. A 53-year-old Indian man presented with a 10-day history of fever, generalised itchy maculopapular rash involving the palms and soles, and jaundice. His past medical history was unremarkable, and he denied taking any medication on a regular basis. He had been living in Italy for the past 26 years, but he had travelled to his L. Ceccarelli G. Calisti (&) D. Delle Rose A. Ricciardi G. Maffongelli P. Sordillo L. Sarmati M. Andreoni Infectious Diseases Unit, Tor Vergata University Hospital, Viale Oxford 81, 00133 Rome, Italy e-mail: giorgiocalisti@gmail.com

We perform a statistical analysis of the peculiar velocity field around dark matter haloes in numerical simulations. We examine different properties of the infall of material onto haloes and its relation to central halo shapes and the shape of the large scale surrounding regions (LSSR). We find that the amplitude of the infall velocity field along the halo shape minor axis is larger than that along the major axis. This is consistent for general triaxial haloes, and for both prolate and oblate systems. We also report a strong anisotropy of the velocity field along the principal axes of the LSSR. The infall velocity field around dark matter haloes reaches a maximum value along the direction of the minor axis of the LSSR, whereas along the direction of its major axis, it exhibits the smallest velocities. We also analyse the dependence of the matter velocity field on the local environment. The amplitude of the infall velocity at high local density regions is larger than at low local density regions. The velocity field tends to be more laminar along the direction towards the minor axis of the LSSR, where the mean ratio between flow velocity and velocity dispersion is of order unity and nearly constant up to scales of 15 Mpc/h. We also detect anisotropies in the outflowing component of the velocity field, showing a maximum amplitude along the surrounding LSSR major axis.

We perform a statistical study of the global motion of cosmic voids using both a numerical simulation and observational data. We analyse their relation to large-scale mass flows and the physical effects that drive those motions. We analyse the bulk motions of voids, defined by the mean velocity of haloes in the surrounding shells in the numerical simulation, and by galaxies in the Sloan Digital Sky Survey Data Release 7. We find void mean bulk velocities close to 400 km/s, comparable to those of haloes (~ 500-600 km/s), depending on void size and the large-scale environment. Statistically, small voids move faster than large ones, and voids in relatively higher density environments have higher bulk velocities than those placed in large underdense regions. Also, we analyze the mean mass density around voids finding, as expected, large-scale overdensities (underdensities) along (opposite to) the void motion direction, suggesting that void motions respond to a pull-push mechanism. This contrasts with massive cluster motions who are mainly governed by the pull of the large-scale overdense regions. Our analysis of void pairwise velocities shows how their relative motions are generated by large-scale density fluctuations. In agreement with linear theory, voids embedded in low (high) density regions mutually recede (attract) each other, providing the general mechanism to understand the bimodal behavior of void motions. In order to compare the theoretical results and the observations we have inferred void motions in the SDSS using linear theory, finding that the estimated observational void motions are in statisticalagreement with the results of the simulation. Regarding large-scale flows, our results suggest a scenario of galaxies and galaxy systems flowing away from void centers with the additional, and morerelevant, contribution of the void bulk motion to the total velocity., 10 pages, 10 figures, Accepted for publication in MNRAS

We perform a statistical study on the distribution and dynamics of voids in the 2dFGRS. Our statistics are tested and calibrated using mock 2dFGRS catalogues. We analyse the dynamics around voids in mock and real 2dFGRS surveys. The void-galaxy cross-correlation redshift-space distortions show evidence of the continuing growth of voids, confirming another prediction of the hierarchical clustering scenario. A non-linear outflow model can be used to provide quantitative estimates of the outflow velocities around 2dFGRS voids. These results are consistent with maximum outflows of 110km/s, 210km/s and 270km/s for voids of =7.5, 12.5 and 17.5h^-1Mpc, assuming a galaxy bias of b=1. As an application for future surveys, our study of the mock catalogues shows that direct measurements of the expansion of voids can be obtained using peculiar velocity data. We find that it would also be possible to detect differences in the velocity dispersion of galaxies in the directions parallel and perpendicular to the void walls., Comment: 13 pages, 13 figures, published in MNRAS

We perform a statistical study focused on void environments. We examine galaxy density profiles around voids in the SDSS, finding a correlation between void--centric distance to the shell of maximum density and void radius when a maximum in overdensity exists. We analyze voids with and without a surrounding over-dense shell in the SDSS. We find that small voids are more frequently surrounded by over-dense shells whereas the radial galaxy density profile of large voids tends to rise smoothly towards the mean galaxy density. We analyse the fraction of voids surrounded by overdense shells finding a continuous trend with void radius. The differences between voids with and without an overdense shell around them can be understood in terms of whether the voids are, on average, in the process of collapsing or continuing their expansion, respectively, in agreement with previous theoretical expectations. We use numerical simulations coupled to semi-analytic models of galaxy formation in order to test and interpret our results. The very good agreement between the mock catalog results and the observations provides additional support to the viability of a LCDM model to reproduce the large scale structure of the universe as defined by the void network, in a way which has not been analysed previously., Comment: Accepted for Publication in MNRAS, 9 pages, 7 figures

We report a case of an immunocompromised patient affected by chronic hepatitis B virus (HBV) with high basal HBV viremia (>8 log(10) IU/ml) who failed an entecavir regimen, despite the absence of primary or secondary drug resistance mutations. The patient achieved sustained virological success (serum HBV DNA

Body piercing, a growing trend especially in young people, is often complicated by severe infections. We present a case of acute bacterial endocarditis by Staphylococcus aureus complicated by multiple cerebral, kidney, spleen embolisms in a young girl, with no known previous cardiac abnormalities, following the piercing of nasal septum. This case highlights the importance of education of patients with and without structural heart disease to the potential dangerous and even life threatening infectious complications of piercing, and stimulate further discussion on the possibility of antibiotic prophylaxis of such procedures.

We study statistical properties of voids in the distribution of mass, dark-matter haloes and galaxies (B_J 10^11.5 M_sun/h, similar to the median halo mass, M_med=10^11.3 M_sun/h. We also find that the number density of galaxy- and halo-defined voids can be up to two orders of magnitude higher than mass-defined voids for large void radii. As expected, there are outflow velocities which show their maximum at larger void-centric distances for larger voids (well described by a linear relation). The void-centric distance where this maximum occurs, follows a suitable power law fit of the form, log(d_vmax)=(r_void/A)^B. At sufficiently large distances, we find mild infall motions onto the sub-dense regions. We find that a similar analysis in redshift space would make both outflows and infalls to appear with a lower amplitude. We also find that the velocity dispersion of galaxies and haloes is larger in the direction parallel to the void walls by ~10-20%. We analyse the void-tracer cross-correlation functions in real- and redshift-space as a function of separation, and also as a function of separations parallel and perpendicular to the line of sight. The distortion pattern observed in xi(sigma,pi) is that of an elongation along the line of sight which extends out to large separations. Positive xi contours evidence finger-of-god motions at the void walls. Elongations along the line of sight are roughly comparable between galaxy-, halo- and mass-defined voids. (Abridged)

Cosmic voids are becoming key players in testing the physics of our Universe. Here we concentrate on the abundances and the dynamics of voids as these are among the best candidates to provide information on cosmological parameters. Cai, Padilla \& Li (2014) use the abundance of voids to tell apart Hu \& Sawicki $f(R)$ models from General Relativity. An interesting result is that even though, as expected, voids in the dark matter field are emptier in $f(R)$ gravity due to the fifth force expelling away from the void centres, this result is reversed when haloes are used to find voids. The abundance of voids in this case becomes even lower in $f(R)$ compared to GR for large voids. Still, the differences are significant and this provides a way to tell apart these models. The velocity field differences between $f(R)$ and GR, on the other hand, are the same for halo voids and for dark matter voids. Paz et al. (2013), concentrate on the velocity profiles around voids. First they show the necessity of four parameters to describe the density profiles around voids given two distinct void populations, voids-in-voids and voids-in-clouds. This profile is used to predict peculiar velocities around voids, and the combination of the latter with void density profiles allows the construction of model void-galaxy cross-correlation functions with redshift space distortions. When these models are tuned to fit the measured correlation functions for voids and galaxies in the Sloan Digital Sky Survey, small voids are found to be of the void-in-cloud type, whereas larger ones are consistent with being void-in-void. This is a novel result that is obtained directly from redshift space data around voids. These profiles can be used to remove systematics on void-galaxy Alcock-Pacinsky tests coming from redshift-space distortions., 8 pages, 4 figures, to appear in the proceedings of IAU308 Symposium "The Zeldovich Universe"

Aim: To investigate the prevalence and genotypic profile of overt and occult hepatitis-B infection (OBI) among HIV-infected individuals in Cameroon. Methods: 212 HIV-infected Cameroonians, aged 37.6 [IQR: 32.6-46.6] followed-up at the University Health Centre in Yaounde, were tested for HBsAg, anti-HBs, anti-HBc IgG/IgM, HBV-DNA and anti-HCV IgG. HBV positive cases were tested for Hepatitis Delta virus (HDV) using anti-HDV IgG and HDV-RNA. Liver function was assessed by alanine and aspartate aminotransaminases. OBI was defined as negative-HBsAg and detectable HBV-DNA. In occult or overt HBVinfected participants, HBV reverse transcriptase (RT)/surface (S) sequences were analyzed for drug resistance, immuneescape mutants, and phylogeny. Results: Overall, 78.3% (166/212) participants had past/ongoing HBV-exposure, with 39.1% (83/212) carrying “HBcAbpositive alone”. Prevalence of overt HBV (positive-HBsAg) was 11.8% (25/212), prevalence of HBV and HDV was respectively 6.9% (12/175) and 12% (3/25). Phylogeny of HBV-RT/S revealed the co-circulation of genotypes A and E. All HBV-coinfected participants harbored HBV strains with at least one immune-escape mutation. Of note, one HBV variant carried the vaccine-escape mutation G145R that hinders HBsAg neutralization by antibodies. For the first time, a novel 9 aa-deletion (s115-s123), located in the HBsAg “a” determinant, was found concomitantly with OBI. A stop codon in the S region (associated with increased risk of hepatocellular carcinoma) was found in six cases. Conclusion: High prevalence of overt/occult HBV-infection and circulating atypical strains highlight the importance of HBV-surveillance among HIV-infected Cameroonians and strategies to detect OBI in highly endemic countries.